| Tuesday, April 6 |
| » Lost to White Sox (1-0), 10-5 | Hubert H. Humphrey Metrodome (0-1) | 0-1 | |
| » W: Jack McDowell (1-0) L: Kevin Tapani (0-1) S: Terry Leach (1) | Second | 1 out |
| Wednesday, April 7 |
| » Defeated White Sox (1-1), 6-1 | Hubert H. Humphrey Metrodome (1-1) | 1-1 | |
| » W: Jim Deshaies (1-0) L: Kirk McCaskill (0-1) S: Rick Aguilera (1) | Second | 1 out |
| Thursday, April 8 |
| » Lost to White Sox (2-1), 9-4 | Hubert H. Humphrey Metrodome (1-2) | 1-2 | |
| » W: Alex Fernandez (1-0) L: Pat Mahomes (0-1) | Fourth | 1½ out |
| » Major-league debuts: Brett Merriman (Twins) |
| Friday, April 9 |
| » Defeated Royals (0-4), 8-7 | Royals Stadium (1-0) | 2-2 | |
| » W: Mike Trombley (1-0) L: Mark Gardner (0-1) S: Rick Aguilera (2) | Third | 1½ out |
| Saturday, April 10 |
| » Defeated Royals (0-5), 3-2 | Royals Stadium (2-0) | 3-2 | Won 2 |
| » W: Willie Banks (1-0) L: Kevin Appier (0-2) S: Rick Aguilera (3) | Second | ½ out |
| Sunday, April 11 |
| » Lost to Royals (1-5), 2-1 | Royals Stadium (2-1) | 3-3 | |
| » W: Tom Gordon (1-0) L: Kevin Tapani (0-2) S: Jeff Montgomery (1) | Fourth | 1½ out |
| Monday, April 12 |
| » Defeated White Sox (3-4), 3-2 | Comiskey Park II (1-0) | 4-3 | |
| » W: Jim Deshaies (2-0) L: Kirk McCaskill (0-2) S: Rick Aguilera (4) | Fourth | 1½ out |
| Tuesday, April 13 |
| » Lost to White Sox (4-4), 4-0 | Comiskey Park II (1-1) | 4-4 | |
| » W: Alex Fernandez (2-0) L: Pat Mahomes (0-2) | Fifth | 2½ out |
| Friday, April 16 |
| » Defeated Royals (2-8), 4-3 | Hubert H. Humphrey Metrodome (2-2) | 5-4 | |
| » W: Mark Guthrie (1-0) L: Rusty Meacham (0-1) | Third | 1 out |
| Saturday, April 17 |
| » Defeated Royals (2-9), 8-2 | Hubert H. Humphrey Metrodome (3-2) | 6-4 | Won 2 |
| » W: Jim Deshaies (3-0) L: David Cone (0-3) S: Mike Hartley (1) | Third | 1 out |
| Sunday, April 18 |
| » Lost to Royals (3-9), 5-4 | Hubert H. Humphrey Metrodome (3-3) | 6-5 | |
| » W: Hipolito Pichardo (1-0) L: Scott Erickson (0-1) S: Jeff Montgomery (3) | Third | 2 out |
| Tuesday, April 20 |
| » Defeated Brewers (4-6), 10-0 | Hubert H. Humphrey Metrodome (4-3) | 7-5 | |
| » W: Willie Banks (2-0) L: Jaime Navarro (0-1) | Third | 1 out |
| Wednesday, April 21 |
| » Lost to Brewers (5-6), 10-8 | Hubert H. Humphrey Metrodome (4-4) | 7-6 | |
| » W: Carlos Maldonado (1-0) L: Mike Hartley (0-1) S: Doug Henry (3) | Third | 1½ out |
| Thursday, April 22 |
| » Defeated Brewers (5-7), 5-4 | Hubert H. Humphrey Metrodome (5-4) | 8-6 | |
| » W: Jim Deshaies (4-0) L: Bill Wegman (1-3) S: Rick Aguilera (5) | Third | 1½ out |
| Friday, April 23 |
| » Lost to Tigers (10-5), 12-4 | Hubert H. Humphrey Metrodome (5-5) | 8-7 | |
| » W: Mike Moore (2-1) L: Scott Erickson (0-2) | Third | 2½ out |
| Saturday, April 24 |
| » Lost to Tigers (11-5), 17-1 | Hubert H. Humphrey Metrodome (5-6) | 8-8 | Lost 2 |
| » W: John Doherty (2-1) L: Pat Mahomes (0-3) | Third | 3½ out |
| Sunday, April 25 |
| » Lost to Tigers (12-5), 16-5 | Hubert H. Humphrey Metrodome (5-7) | 8-9 | Lost 3 |
| » W: Mark Leiter (1-1) L: Mark Guthrie (1-1) | Third | 4½ out |
| Monday, April 26 |
| » Lost to Brewers (7-9), 10-3 | County Stadium (0-1) | 8-10 | Lost 4 |
| » W: Ricky Bones (1-1) L: Kevin Tapani (0-3) | Fifth | 5 out |
| » Major-league debuts: George Tsamis (Twins) |
| Tuesday, April 27 |
| » Lost to Brewers (8-9), 3-2 | County Stadium (0-2) | 8-11 | Lost 5 |
| » W: Bill Wegman (2-3) L: Jim Deshaies (4-1) S: Doug Henry (4) | Fifth | 5 out |
| Wednesday, April 28 |
| » Lost to Orioles (6-13), 8-4 | Oriole Park at Camden Yards (0-1) | 8-12 | Lost 6 |
| » W: Arthur Rhodes (1-1) L: Scott Erickson (0-3) | Sixth | 6 out |
| Thursday, April 29 |
| » Lost to Orioles (7-13), 11-0 | Oriole Park at Camden Yards (0-2) | 8-13 | Lost 7 |
| » W: Mike Mussina (3-1) L: Pat Mahomes (0-4) | Sixth | 6½ out |
| Friday, April 30 |
| » Lost to Tigers (15-7), 8-0 | Tiger Stadium (0-1) | 8-14 | Lost 8 |
| » W: David Wells (4-0) L: Willie Banks (2-1) | Seventh | 6½ out |
| Saturday, May 1 |
| » Defeated Tigers (15-8), 5-2 | Tiger Stadium (1-1) | 9-14 | |
| » W: Kevin Tapani (1-3) L: Tom Bolton (1-1) S: Rick Aguilera (6) | Sixth | 5½ out |
| Sunday, May 2 |
| » Defeated Tigers (15-9), 6-3 | Tiger Stadium (2-1) | 10-14 | Won 2 |
| » W: Mike Trombley (2-0) L: Dave Haas (1-1) S: Rick Aguilera (7) | Fifth | 4½ out |
| Monday, May 3 |
| » Defeated Orioles (9-15), 4-3 | Hubert H. Humphrey Metrodome (6-7) | 11-14 | Won 3 |
| » W: Scott Erickson (1-3) L: Arthur Rhodes (1-2) S: Rick Aguilera (8) | Fifth | 3½ out |
| Wednesday, May 5 |
| » Lost to Orioles (10-15), 3-0 | Hubert H. Humphrey Metrodome (6-8) | 11-15 | |
| » W: Mike Mussina (4-1) L: Willie Banks (2-2) | Fourth | 4 out |
| » Major-league debuts: Pat Meares (Twins) |
| Friday, May 7 |
| » Defeated Mariners (14-15), 5-4 | Kingdome (1-0) | 12-15 | |
| » W: Mark Guthrie (2-1) L: Russ Swan (1-2) S: Rick Aguilera (9) | Fifth | 4½ out |
| Saturday, May 8 |
| » Lost to Mariners (15-15), 7-2 | Kingdome (1-1) | 12-16 | |
| » W: Erik Hanson (5-0) L: Jim Deshaies (4-2) | Fifth | 5 out |
| Sunday, May 9 |
| » Lost to Mariners (16-15), 6-4 | Kingdome (1-2) | 12-17 | Lost 2 |
| » W: Tim Leary (2-1) L: Scott Erickson (1-4) S: Norm Charlton (6) | Fifth | 6 out |
| Monday, May 10 |
| » Defeated Angels (17-12), 13-3 | Anaheim Stadium (1-0) | 13-17 | |
| » W: Willie Banks (3-2) L: John Farrell (2-4) | Fourth | 6 out |
| Tuesday, May 11 |
| » Lost to Angels (18-12), 5-3 | Anaheim Stadium (1-1) | 13-18 | |
| » W: Scott Sanderson (5-1) L: Mike Trombley (2-1) S: Joe Grahe (3) | Sixth | 6 out |
| Wednesday, May 12 |
| » Defeated Angels (18-13), 5-2 | Anaheim Stadium (2-1) | 14-18 | |
| » W: Kevin Tapani (2-3) L: Chuck Finley (3-3) S: Rick Aguilera (10) | Fifth | 6 out |
| Friday, May 14 |
| » Defeated Red Sox (19-16), 4-3 | Hubert H. Humphrey Metrodome (7-8) | 15-18 | Won 2 |
| » W: Scott Erickson (2-4) L: Frank Viola (4-3) S: Rick Aguilera (11) | Fifth | 6 out |
| Saturday, May 15 |
| » Defeated Red Sox (19-17), 7-4 | Hubert H. Humphrey Metrodome (8-8) | 16-18 | Won 3 |
| » W: Jim Deshaies (5-2) L: John Dopson (2-2) S: Rick Aguilera (12) | Fifth | 5 out |
| Sunday, May 16 |
| » Lost to Red Sox (20-17), 11-5 | Hubert H. Humphrey Metrodome (8-9) | 16-19 | |
| » W: Joe Hesketh (3-3) L: Mike Hartley (0-2) | Fifth | 6 out |
| Monday, May 17 |
| » Lost to Yankees (21-17), 11-5 | Hubert H. Humphrey Metrodome (8-10) | 16-20 | Lost 2 |
| » W: Jimmy Key (4-1) L: Kevin Tapani (2-4) | Sixth | 6 out |
| » Major-league debuts: David McCarty (Twins) |
| Tuesday, May 18 |
| » Lost to Yankees (22-17), 5-3 | Hubert H. Humphrey Metrodome (8-11) | 16-21 | Lost 3 |
| » W: Jim Abbott (3-5) L: Mike Trombley (2-2) S: Steve Farr (9) | Sixth | 7 out |
| Wednesday, May 19 |
| » Lost to Yankees (23-17), 11-6 | Hubert H. Humphrey Metrodome (8-12) | 16-22 | Lost 4 |
| » W: Rich Monteleone (4-3) L: Scott Erickson (2-5) | Sixth | 7 out |
| Friday, May 21 |
| » Lost to Blue Jays (22-19), 11-2 | Skydome (0-1) | 16-23 | Lost 5 |
| » W: Jack Morris (2-4) L: Jim Deshaies (5-3) | Seventh | 7 out |
| Saturday, May 22 |
| » Lost to Blue Jays (23-19), 7-0 | Skydome (0-2) | 16-24 | Lost 6 |
| » W: Danny Cox (4-0) L: Kevin Tapani (2-5) | Seventh | 7 out |
| Sunday, May 23 |
| » Lost to Blue Jays (24-19), 2-1 | Skydome (0-3) | 16-25 | Lost 7 |
| » W: Pat Hentgen (6-2) L: Scott Erickson (2-6) S: Duane Ward (11) | Seventh | 8 out |
| Tuesday, May 25 |
| » Lost to Athletics (18-23), 3-1 | Oakland-Alameda County Stadium (0-1) | 16-26 | Lost 8 |
| » W: Storm Davis (1-4) L: Jim Deshaies (5-4) S: Dennis Eckersley (9) | Seventh | 8 out |
| » Major-league debuts: Marcos Armas (Athletics) |
| Wednesday, May 26 |
| » Defeated Athletics (18-24), 12-11 | Oakland-Alameda County Stadium (1-1) | 17-26 | |
| » W: George Tsamis (1-0) L: Joe Boever (1-1) | Seventh | 7 out |
| Friday, May 28 |
| » Defeated Indians (19-29), 7-6 | Hubert H. Humphrey Metrodome (9-12) | 18-26 | Won 2 |
| » W: Rick Aguilera (1-0) L: Ted Power (0-2) | Seventh | 6½ out |
| Saturday, May 29 |
| » Defeated Indians (19-30), 9-3 | Hubert H. Humphrey Metrodome (10-12) | 19-26 | Won 3 |
| » W: Willie Banks (4-2) L: Mike Bielecki (4-4) | Sixth | 6½ out |
| Sunday, May 30 |
| » Defeated Indians (19-31), 8-2 | Hubert H. Humphrey Metrodome (11-12) | 20-26 | Won 4 |
| » W: Jim Deshaies (6-4) L: Tom Kramer (1-2) S: Mike Trombley (1) | Fifth | 6½ out |
| Monday, May 31 |
| » Lost to Rangers (25-24), 1-0 | Hubert H. Humphrey Metrodome (11-13) | 20-27 | |
| » W: Charlie Leibrandt (6-2) L: Kevin Tapani (2-6) S: Tom Henke (9) | Sixth | 6½ out |
| Tuesday, June 1 |
| » Defeated Rangers (25-25), 7-5 | Hubert H. Humphrey Metrodome (12-13) | 21-27 | |
| » W: Pat Mahomes (1-4) L: Brian Bohanon (2-1) S: Rick Aguilera (13) | Sixth | 5½ out |
| Wednesday, June 2 |
| » Defeated Rangers (25-26), 6-3 | Hubert H. Humphrey Metrodome (13-13) | 22-27 | Won 2 |
| » W: Willie Banks (5-2) L: Roger Pavlik (1-2) S: Rick Aguilera (14) | Fifth | 4½ out |
| Friday, June 4 |
| » Defeated Indians (20-34), 3-2 | Cleveland Stadium (1-0) | 23-27 | Won 3 |
| » W: Jim Deshaies (7-4) L: Jeremy Hernandez (0-3) S: Rick Aguilera (15) | Sixth | 5 out |
| Saturday, June 5 |
| » Lost to Indians (21-34), 7-6 | Cleveland Stadium (1-1) | 23-28 | |
| » W: Eric Plunk (2-2) L: Mike Trombley (2-3) | Sixth | 5 out |
| Sunday, June 6 |
| » Defeated Indians (21-35), 5-4 | Cleveland Stadium (2-1) | 24-28 | |
| » W: Scott Erickson (3-6) L: Dennis Cook (3-4) S: Rick Aguilera (16) | Fifth | 5 out |
| Monday, June 7 |
| » Lost to Rangers (28-27), 8-2 | Arlington Stadium (0-1) | 24-29 | |
| » W: Roger Pavlik (2-2) L: Pat Mahomes (1-5) | Sixth | 6 out |
| Tuesday, June 8 |
| » Defeated Rangers (28-28), 3-2 | Arlington Stadium (1-1) | 25-29 | |
| » W: Carl Willis (1-0) L: Matt Whiteside (1-1) S: Rick Aguilera (17) | Fifth | 5 out |
| Thursday, June 10 |
| » Defeated Rangers (28-29), 6-5 | Arlington Stadium (2-1) | 26-29 | Won 2 |
| » W: Kevin Tapani (3-6) L: Charlie Leibrandt (6-3) S: Rick Aguilera (18) | Fourth | 5 out |
| Friday, June 11 |
| » Defeated Athletics (21-34), 11-8 | Hubert H. Humphrey Metrodome (14-13) | 27-29 | Won 3 |
| » W: Mike Trombley (3-3) L: Edwin Nunez (1-3) S: Rick Aguilera (19) | Fourth | 4 out |
| Saturday, June 12 |
| » Defeated Athletics (21-35), 7-2 | Hubert H. Humphrey Metrodome (15-13) | 28-29 | Won 4 |
| » W: Jim Deshaies (8-4) L: Bobby Witt (5-4) | Fourth | 3 out |
| Sunday, June 13 |
| » Lost to Athletics (22-35), 7-6 | Hubert H. Humphrey Metrodome (15-14) | 28-30 | |
| » W: Edwin Nunez (2-3) L: George Tsamis (1-1) S: Dennis Eckersley (11) | Fourth | 4 out |
| » Major-league debuts: Eddie Guardado (Twins) |
| Monday, June 14 |
| » Defeated Blue Jays (36-28), 4-3 | Hubert H. Humphrey Metrodome (16-14) | 29-30 | |
| » W: Larry Casian (1-0) L: Danny Cox (5-2) S: Carl Willis (1) | Third | 3 out |
| Tuesday, June 15 |
| » Lost to Blue Jays (37-28), 6-3 | Hubert H. Humphrey Metrodome (16-15) | 29-31 | |
| » W: Juan Guzman (6-1) L: Kevin Tapani (3-7) S: Duane Ward (18) | Sixth | 3 out |
| Wednesday, June 16 |
| » Lost to Blue Jays (38-28), 4-0 | Hubert H. Humphrey Metrodome (16-16) | 29-32 | Lost 2 |
| » W: Jack Morris (4-7) L: Scott Erickson (3-7) | Sixth | 4 out |
| Thursday, June 17 |
| » Lost to Yankees (38-29), 6-5 | Yankee Stadium (0-1) | 29-33 | Lost 3 |
| » W: Bobby Munoz (1-0) L: Larry Casian (1-1) S: Steve Farr (17) | Sixth | 4½ out |
| Friday, June 18 |
| » Lost to Yankees (39-29), 5-0 | Yankee Stadium (0-2) | 29-34 | Lost 4 |
| » W: Jimmy Key (8-2) L: Eddie Guardado (0-1) | Fifth | 4½ out |
| Saturday, June 19 |
| » Lost to Yankees (40-29), 8-4 | Yankee Stadium (0-3) | 29-35 | Lost 5 |
| » W: Scott Kamieniecki (2-1) L: Willie Banks (5-3) | Sixth | 5½ out |
| Sunday, June 20 |
| » Lost to Yankees (41-29), 8-0 | Yankee Stadium (0-4) | 29-36 | Lost 6 |
| » W: Bob Wickman (8-0) L: Kevin Tapani (3-8) | Fifth | 5½ out |
| Monday, June 21 |
| » Lost to Red Sox (31-38), 6-3 | Fenway Park (0-1) | 29-37 | Lost 7 |
| » W: John Dopson (5-5) L: Scott Erickson (3-8) S: Jeff Russell (15) | Fourth | 5½ out |
| Tuesday, June 22 |
| » Lost to Red Sox (32-38), 4-1 | Fenway Park (0-2) | 29-38 | Lost 8 |
| » W: Paul Quantrill (3-5) L: Jim Deshaies (8-5) S: Jeff Russell (16) | Fifth | 6½ out |
| Wednesday, June 23 |
| » Lost to Red Sox (33-38), 3-1 | Fenway Park (0-3) | 29-39 | Lost 9 |
| » W: Aaron Sele (1-0) L: Eddie Guardado (0-2) S: Greg Harris (1) | Fifth | 7½ out |
| » Major-league debuts: Aaron Sele (Red Sox) |
| Friday, June 25 |
| » Defeated Angels (36-35), 8-5 | Hubert H. Humphrey Metrodome (17-16) | 30-39 | |
| » W: Scott Erickson (4-8) L: Russ Springer (0-2) S: Rick Aguilera (20) | Sixth | 6½ out |
| Saturday, June 26 |
| » Lost to Angels (37-35), 4-0 | Hubert H. Humphrey Metrodome (17-17) | 30-40 | |
| » W: Chuck Finley (9-5) L: Willie Banks (5-4) | Fifth | 7½ out |
| Sunday, June 27 |
| » Defeated Angels (37-36), 2-0 | Hubert H. Humphrey Metrodome (18-17) | 31-40 | |
| » W: Jim Deshaies (9-5) L: Scott Sanderson (7-8) S: Rick Aguilera (21) | Fifth | 7½ out |
| » Major-league debuts: Derek Lee (Twins) |
| Monday, June 28 |
| » Lost to Mariners (37-39), 4-1 | Hubert H. Humphrey Metrodome (18-18) | 31-41 | |
| » W: Dave Fleming (3-1) L: Kevin Tapani (3-9) S: Norm Charlton (15) | Sixth | 7½ out |
| Tuesday, June 29 |
| » Defeated Mariners (37-40), 7-5 | Hubert H. Humphrey Metrodome (19-18) | 32-41 | |
| » W: Mike Trombley (4-3) L: Bob Ayrault (2-1) S: Rick Aguilera (22) | Sixth | 6½ out |
| Wednesday, June 30 |
| » Lost to Mariners (38-40), 5-3 | Hubert H. Humphrey Metrodome (19-19) | 32-42 | |
| » W: Randy Johnson (10-4) L: Scott Erickson (4-9) S: Norm Charlton (16) | Sixth | 6½ out |
| Thursday, July 1 |
| » Lost to Mariners (39-40), 6-1 | Hubert H. Humphrey Metrodome (19-20) | 32-43 | Lost 2 |
| » W: Erik Hanson (6-6) L: Willie Banks (5-5) | Seventh | 6½ out |
| Friday, July 2 |
| » Defeated Brewers (32-45), 11-10 | Hubert H. Humphrey Metrodome (20-20) | 33-43 | |
| » W: Larry Casian (2-1) L: Mike Fetters (2-1) | Seventh | 6½ out |
| Saturday, July 3 |
| » Lost to Brewers (33-45), 3-1 | Hubert H. Humphrey Metrodome (20-21) | 33-44 | |
| » W: Ricky Bones (5-5) L: Kevin Tapani (3-10) S: Doug Henry (15) | Fifth | 6½ out |
| Sunday, July 4 |
| » Defeated Brewers (33-46), 4-3 | Hubert H. Humphrey Metrodome (21-21) | 34-44 | |
| » W: Eddie Guardado (1-2) L: Jaime Navarro (5-5) S: Rick Aguilera (23) | Fifth | 6½ out |
| Monday, July 5 |
| » Defeated Tigers (44-38), 13-3 | Hubert H. Humphrey Metrodome (22-21) | 35-44 | Won 2 |
| » W: Scott Erickson (5-9) L: David Wells (9-4) | Sixth | 6½ out |
| Tuesday, July 6 |
| » Lost to Tigers (45-38), 4-1 | Hubert H. Humphrey Metrodome (22-22) | 35-45 | |
| » W: John Doherty (8-4) L: Willie Banks (5-6) S: Mike Henneman (13) | Sixth | 6½ out |
| Wednesday, July 7 |
| » Lost to Tigers (46-38), 8-4 | Hubert H. Humphrey Metrodome (22-23) | 35-46 | Lost 2 |
| » W: Bill Gullickson (5-4) L: Jim Deshaies (9-6) | Sixth | 7½ out |
| » Major-league debuts: Sean Bergman (Tigers) |
| Thursday, July 8 |
| » Lost to Brewers (35-48), 15-3 | County Stadium (0-3) | 35-47 | Lost 3 |
| » W: Ricky Bones (6-5) L: Kevin Tapani (3-11) | Sixth | 8½ out |
| Friday, July 9 |
| » Defeated Brewers (35-49), 10-6 | County Stadium (1-3) | 36-47 | |
| » W: Carl Willis (2-0) L: Jaime Navarro (5-6) | Seventh | 7½ out |
| Saturday, July 10 |
| » Lost to Brewers (36-49), 5-4 | County Stadium (1-4) | 36-48 | |
| » W: Doug Henry (2-2) L: Rick Aguilera (1-1) | Sixth | 7½ out |
| Sunday, July 11 |
| » Lost to Brewers (37-49), 5-4 | County Stadium (1-5) | 36-49 | Lost 2 |
| » W: Cal Eldred (10-8) L: Willie Banks (5-7) S: Doug Henry (16) | Sixth | 8½ out |
| Thursday, July 15 |
| » Lost to Orioles (48-41), 5-3 | Oriole Park at Camden Yards (0-3) | 36-50 | Lost 3 |
| » W: Ben McDonald (6-8) L: Scott Erickson (5-10) S: Gregg Olson (24) | Seventh | 9½ out |
| Friday, July 16 |
| » Lost to Orioles (49-41), 9-7 | Oriole Park at Camden Yards (0-4) | 36-51 | Lost 4 |
| » W: Mike Mussina (11-4) L: Jim Deshaies (9-7) S: Gregg Olson (25) | Seventh | 10½ out |
| Saturday, July 17 |
| » Defeated Orioles (49-42), 4-2 | Oriole Park at Camden Yards (1-4) | 37-51 | |
| » W: Kevin Tapani (4-11) L: Rick Sutcliffe (8-5) S: Rick Aguilera (24) | Sixth | 10½ out |
| Sunday, July 18 |
| » Lost to Orioles (50-42), 7-2 | Oriole Park at Camden Yards (1-5) | 37-52 | |
| » W: Fernando Valenzuela (5-7) L: Eddie Guardado (1-3) | Sixth | 11½ out |
| Former Twin Ted Sadowski dies in Shaler Twsp., PA at the age of 58. |
| Monday, July 19 |
| » Defeated Tigers (50-43), 4-2 | Tiger Stadium (3-1) | 38-52 | |
| » W: Scott Erickson (6-10) L: Sean Bergman (1-1) S: Rick Aguilera (25) | Seventh | 10½ out |
| » Major-league debuts: Chris Gomez (Tigers) |
| Tuesday, July 20 |
| » Defeated Tigers (50-44), 4-3 | Tiger Stadium (4-1) | 39-52 | Won 2 |
| » W: Jim Deshaies (10-7) L: Mark Leiter (6-6) S: Rick Aguilera (26) | Seventh | 10½ out |
| Wednesday, July 21 |
| » Defeated Tigers (50-45), 7-2 | Tiger Stadium (5-1) | 40-52 | Won 3 |
| » W: Kevin Tapani (5-11) L: David Wells (9-6) S: Carl Willis (2) | Seventh | 9½ out |
| Thursday, July 22 |
| » Defeated Orioles (52-44), 8-4 | Hubert H. Humphrey Metrodome (23-23) | 41-52 | Won 4 |
| » W: Willie Banks (6-7) L: Rick Sutcliffe (8-6) S: Mike Trombley (2) | Sixth | 9½ out |
| Friday, July 23 |
| » Lost to Orioles (53-44), 5-1 | Hubert H. Humphrey Metrodome (23-24) | 41-53 | |
| » W: Fernando Valenzuela (6-7) L: Eddie Guardado (1-4) | Sixth | 9½ out |
| Saturday, July 24 |
| » Lost to Orioles (54-44), 9-2 | Hubert H. Humphrey Metrodome (23-25) | 41-54 | Lost 2 |
| » W: Jamie Moyer (7-4) L: Scott Erickson (6-11) S: Jim Poole (1) | Sixth | 10½ out |
| Sunday, July 25 |
| » Defeated Orioles (54-45), 5-2 | Hubert H. Humphrey Metrodome (24-25) | 42-54 | |
| » W: Jim Deshaies (11-7) L: Ben McDonald (7-9) S: Rick Aguilera (27) | Sixth | 9½ out |
| Tuesday, July 27 |
| » Lost to Mariners (50-50), 10-8 | Kingdome (1-3) | 42-55 | |
| » W: Rich DeLucia (3-5) L: George Tsamis (1-2) S: Jeff Nelson (1) | Sixth | 11 out |
| Wednesday, July 28 |
| » Defeated Mariners (50-51), 5-1 | Kingdome (2-3) | 43-55 | |
| » W: Willie Banks (7-7) L: Randy Johnson (10-7) S: Larry Casian (1) | Sixth | 11 out |
| Thursday, July 29 |
| » Lost to Mariners (51-51), 4-3 | Kingdome (2-4) | 43-56 | |
| » W: Tim Leary (8-4) L: Scott Erickson (6-12) S: Ted Power (1) | Sixth | 11½ out |
| Friday, July 30 |
| » Lost to Angels (47-55), 4-2 | Anaheim Stadium (2-2) | 43-57 | Lost 2 |
| » W: Hilly Hathaway (2-1) L: Jim Deshaies (11-8) S: Mike Butcher (3) | Sixth | 12½ out |
| Saturday, July 31 |
| » Lost to Angels (48-55), 4-3 | Anaheim Stadium (2-3) | 43-58 | Lost 3 |
| » W: Chuck Finley (12-8) L: Rick Aguilera (1-2) | Sixth | 13½ out |
| Sunday, August 1 |
| » Defeated Angels (48-56), 9-2 | Anaheim Stadium (3-3) | 44-58 | |
| » W: Eddie Guardado (2-4) L: Russ Springer (1-6) | Sixth | 13½ out |
| Tuesday, August 3 |
| » Defeated Red Sox (59-47), 6-1 | Hubert H. Humphrey Metrodome (25-25) | 45-58 | Won 2 |
| » W: Willie Banks (8-7) L: John Dopson (7-6) | Sixth | 13 out |
| Wednesday, August 4 |
| » Lost to Red Sox (60-47), 5-4 | Hubert H. Humphrey Metrodome (25-26) | 45-59 | |
| » W: Aaron Sele (6-0) L: Scott Erickson (6-13) S: Jeff Russell (29) | Sixth | 13 out |
| Thursday, August 5 |
| » Lost to Red Sox (61-47), 2-1 | Hubert H. Humphrey Metrodome (25-27) | 45-60 | Lost 2 |
| » W: Frank Viola (7-8) L: Jim Deshaies (11-9) S: Jeff Russell (30) | Fifth | 13 out |
| Friday, August 6 |
| » Defeated Yankees (62-49), 4-3 | Hubert H. Humphrey Metrodome (26-27) | 46-60 | |
| » W: Kevin Tapani (6-11) L: Bob Wickman (10-4) | Sixth | 12 out |
| Former Twin Bob Miller dies in Rancho Bernardo, CA at the age of 55. |
| Saturday, August 7 |
| » Defeated Yankees (62-50), 6-5 | Hubert H. Humphrey Metrodome (27-27) | 47-60 | Won 2 |
| » W: Carl Willis (3-0) L: Bobby Munoz (2-3) | Fifth | 12 out |
| Sunday, August 8 |
| » Lost to Yankees (63-50), 8-6 | Hubert H. Humphrey Metrodome (27-28) | 47-61 | |
| » W: Steve Farr (2-2) L: Rick Aguilera (1-3) | Fifth | 12 out |
| » Major-league debuts: Domingo Jean (Yankees) |
| Tuesday, August 10 |
| » Lost to Blue Jays (65-49), 6-3 | Skydome (0-4) | 47-62 | Lost 2 |
| » W: Dave Stewart (7-6) L: Scott Erickson (6-14) S: Duane Ward (29) | Sixth | 13½ out |
| Wednesday, August 11 |
| » Lost to Blue Jays (66-49), 4-2 | Skydome (0-5) | 47-63 | Lost 3 |
| » W: Juan Guzman (8-3) L: Jim Deshaies (11-10) S: Duane Ward (30) | Sixth | 13½ out |
| Thursday, August 12 |
| » Defeated Blue Jays (66-50), 9-2 | Skydome (1-5) | 48-63 | |
| » W: Kevin Tapani (7-11) L: Jack Morris (6-11) | Sixth | 12½ out |
| Friday, August 13 |
| » Defeated Athletics (47-65), 5-2 | Oakland-Alameda County Stadium (2-1) | 49-63 | Won 2 |
| » W: Eddie Guardado (3-4) L: Ron Darling (4-6) S: Rick Aguilera (28) | Sixth | 12½ out |
| Saturday, August 14 |
| » Defeated Athletics (47-66), 5-1 | Oakland-Alameda County Stadium (3-1) | 50-63 | Won 3 |
| » W: Larry Casian (3-1) L: Rick Honeycutt (0-3) | Sixth | 12 out |
| » Defeated Athletics (47-67), 6-2 | Oakland-Alameda County Stadium (4-1) | 51-63 | Won 4 |
| » W: Mike Trombley (5-3) L: Kelly Downs (3-7) S: George Tsamis (1) | Sixth | 12 out |
| Sunday, August 15 |
| » Defeated Athletics (47-68), 12-5 | Oakland-Alameda County Stadium (5-1) | 52-63 | Won 5 |
| » W: Scott Erickson (7-14) L: Mike Mohler (1-4) | Sixth | 11 out |
| Tuesday, August 17 |
| » Lost to Royals (62-57), 3-2 | Hubert H. Humphrey Metrodome (27-29) | 52-64 | |
| » W: Chris Haney (8-5) L: Jim Deshaies (11-11) S: Jeff Montgomery (37) | Sixth | 12 out |
| Wednesday, August 18 |
| » Lost to Royals (63-57), 5-2 | Hubert H. Humphrey Metrodome (27-30) | 52-65 | Lost 2 |
| » W: Kevin Appier (14-6) L: Kevin Tapani (7-12) S: Jeff Montgomery (38) | Sixth | 12 out |
| Thursday, August 19 |
| » Lost to Royals (64-57), 4-2 | Hubert H. Humphrey Metrodome (27-31) | 52-66 | Lost 3 |
| » W: David Cone (9-11) L: Eddie Guardado (3-5) | Sixth | 12½ out |
| Friday, August 20 |
| » Lost to White Sox (66-54), 4-2 | Hubert H. Humphrey Metrodome (27-32) | 52-67 | Lost 4 |
| » W: Alex Fernandez (15-6) L: Scott Erickson (7-15) S: Roberto Hernandez (27) | Sixth | 13½ out |
| Saturday, August 21 |
| » Lost to White Sox (67-54), 9-4 | Hubert H. Humphrey Metrodome (27-33) | 52-68 | Lost 5 |
| » W: Tim Belcher (11-8) L: Willie Banks (8-8) S: Roberto Hernandez (28) | Sixth | 14½ out |
| Sunday, August 22 |
| » Lost to White Sox (68-54), 1-0 | Hubert H. Humphrey Metrodome (27-34) | 52-69 | Lost 6 |
| » W: Jack McDowell (20-7) L: Jim Deshaies (11-12) | Sixth | 15½ out |
| Monday, August 23 |
| » Defeated Royals (65-60), 3-2 | Royals Stadium (3-1) | 53-69 | |
| » W: Larry Casian (4-1) L: Jeff Montgomery (3-4) S: Carl Willis (3) | Sixth | 14½ out |
| Tuesday, August 24 |
| » Lost to Royals (66-60), 5-3 | Royals Stadium (3-2) | 53-70 | |
| » W: David Cone (10-11) L: Eddie Guardado (3-6) S: Jeff Montgomery (39) | Sixth | 15½ out |
| Wednesday, August 25 |
| » Defeated Royals (66-61), 4-2 | Royals Stadium (4-2) | 54-70 | |
| » W: Scott Erickson (8-15) L: Tom Gordon (8-5) S: Carl Willis (4) | Sixth | 14½ out |
| Thursday, August 26 |
| » Lost to Royals (67-61), 3-0 | Royals Stadium (4-3) | 54-71 | |
| » W: Mike Magnante (1-1) L: Willie Banks (8-9) S: Jeff Montgomery (40) | Sixth | 15 out |
| Friday, August 27 |
| » Lost to White Sox (70-56), 7-3 | Comiskey Park II (1-2) | 54-72 | Lost 2 |
| » W: Tim Belcher (12-8) L: Jim Deshaies (11-13) | Sixth | 15 out |
| » Defeated White Sox (70-57), 7-2 | Comiskey Park II (2-2) | 55-72 | |
| » W: Larry Casian (5-1) L: Donn Pall (2-3) | Sixth | 15 out |
| Saturday, August 28 |
| » Lost to White Sox (71-57), 4-1 | Comiskey Park II (2-3) | 55-73 | |
| » W: Jason Bere (6-5) L: Kevin Tapani (7-13) | Sixth | 16 out |
| Sunday, August 29 |
| » Lost to White Sox (72-57), 13-5 | Comiskey Park II (2-4) | 55-74 | Lost 2 |
| » W: Kirk McCaskill (4-7) L: Eddie Guardado (3-7) | Sixth | 17 out |
| Monday, August 30 |
| » Lost to White Sox (73-57), 4-1 | Comiskey Park II (2-5) | 55-75 | Lost 3 |
| » W: Alex Fernandez (16-6) L: Scott Erickson (8-16) S: Roberto Hernandez (30) | Sixth | 18 out |
| Tuesday, August 31 |
| » Defeated Indians (62-70), 5-4 | Hubert H. Humphrey Metrodome (28-34) | 56-75 | |
| » W: Brett Merriman (1-0) L: Jason Grimsley (1-2) | Sixth | 18 out |
| Wednesday, September 1 |
| » Lost to Indians (63-70), 12-7 | Hubert H. Humphrey Metrodome (28-35) | 56-76 | |
| » W: Derek Lilliquist (3-2) L: Mike Trombley (5-4) S: Eric Plunk (14) | Sixth | 19 out |
| Thursday, September 2 |
| » Lost to Indians (64-70), 4-3 | Hubert H. Humphrey Metrodome (28-36) | 56-77 | Lost 2 |
| » W: Tom Kramer (7-3) L: Kevin Tapani (7-14) S: Jerry Dipoto (5) | Sixth | 19 out |
| » Major-league debuts: Manny Ramirez (Indians) |
| Friday, September 3 |
| » Defeated Rangers (70-64), 9-5 | Hubert H. Humphrey Metrodome (29-36) | 57-77 | |
| » W: Greg Brummett (3-3) L: Steve Dreyer (2-2) S: Rick Aguilera (29) | Sixth | 19 out |
| Saturday, September 4 |
| » Lost to Rangers (71-64), 6-4 | Hubert H. Humphrey Metrodome (29-37) | 57-78 | |
| » W: Kevin Brown (11-11) L: Scott Erickson (8-17) S: Tom Henke (32) | Sixth | 20 out |
| Sunday, September 5 |
| » Defeated Rangers (71-65), 8-3 | Hubert H. Humphrey Metrodome (30-37) | 58-78 | |
| » W: Willie Banks (9-9) L: Kenny Rogers (14-8) | Sixth | 20 out |
| Tuesday, September 7 |
| » Defeated Indians (65-73), 6-0 | Cleveland Stadium (3-1) | 59-78 | Won 2 |
| » W: Kevin Tapani (8-14) L: Jason Grimsley (1-3) | Sixth | 18½ out |
| Wednesday, September 8 |
| » Lost to Indians (66-73), 15-8 | Cleveland Stadium (3-2) | 59-79 | |
| » W: Jose Mesa (10-10) L: Greg Brummett (3-4) | Sixth | 19½ out |
| Thursday, September 9 |
| » Defeated Indians (66-74), 5-3 | Cleveland Stadium (4-2) | 60-79 | |
| » W: Rick Aguilera (2-3) L: Derek Lilliquist (3-3) | Sixth | 19 out |
| Friday, September 10 |
| » Lost to Rangers (75-65), 4-3 | Arlington Stadium (2-2) | 60-80 | |
| » W: Kenny Rogers (15-8) L: Willie Banks (9-10) S: Tom Henke (35) | Sixth | 19½ out |
| » Lost to Rangers (76-65), 3-2 | Arlington Stadium (2-3) | 60-81 | Lost 2 |
| » W: Cris Carpenter (2-2) L: Larry Casian (5-2) S: Tom Henke (36) | Sixth | 19½ out |
| » Major-league debuts: Rich Becker Denny Hocking and Scott Stahoviak (Twins) |
| Saturday, September 11 |
| » Lost to Rangers (77-65), 7-4 | Arlington Stadium (2-4) | 60-82 | Lost 3 |
| » W: Rick Reed (1-0) L: Larry Casian (5-3) S: Gene Nelson (5) | Sixth | 20½ out |
| Sunday, September 12 |
| » Defeated Rangers (77-66), 4-2 | Arlington Stadium (3-4) | 61-82 | |
| » W: Kevin Tapani (9-14) L: Nolan Ryan (5-4) S: Rick Aguilera (30) | Sixth | 19½ out |
| Monday, September 13 |
| » Lost to Athletics (57-85), 7-2 | Hubert H. Humphrey Metrodome (30-38) | 61-83 | |
| » W: Bobby Witt (11-12) L: Scott Erickson (8-18) | Sixth | 19½ out |
| Tuesday, September 14 |
| » Lost to Athletics (58-85), 8-3 | Hubert H. Humphrey Metrodome (30-39) | 61-84 | Lost 2 |
| » W: Steve Karsay (2-3) L: Eddie Guardado (3-8) S: Roger Smithberg (1) | Sixth | 20½ out |
| Wednesday, September 15 |
| » Lost to Athletics (59-85), 15-2 | Hubert H. Humphrey Metrodome (30-40) | 61-85 | Lost 3 |
| » W: Todd VanPoppel (5-5) L: Willie Banks (9-11) | Sixth | 21½ out |
| Thursday, September 16 |
| » Defeated Athletics (59-86), 5-4 | Hubert H. Humphrey Metrodome (31-40) | |