| Monday, January 11 |
| Former Red Sox Frank Quinn dies in Boynton Beach, FL at the age of 66. |
| Wednesday, February 10 |
| Former Red Sox Rip Repulski dies in Waite Park, MN at the age of 66. |
| Monday, April 5 |
| » Defeated Royals (0-1), 3-1 | Royals Stadium (1-0) | 1-0 | |
| » W: Roger Clemens (1-0) L: Kevin Appier (0-1) S: Jeff Russell (1) | First | -- |
| Wednesday, April 7 |
| » Defeated Royals (0-2), 3-2 | Royals Stadium (2-0) | 2-0 | Won 2 |
| » W: Frank Viola (1-0) L: David Cone (0-1) S: Jeff Russell (2) | First | -- |
| » Major-league debuts: Phil Hiatt (Royals) |
| Thursday, April 8 |
| » Defeated Royals (0-3), 9-4 | Royals Stadium (3-0) | 3-0 | Won 3 |
| » W: Scott Bankhead (1-0) L: Mark Gubicza (0-1) | First | -- |
| » Major-league debuts: Billy Brewer (Royals) |
| Friday, April 9 |
| » Lost to Rangers (3-0), 3-1 | Arlington Stadium (0-1) | 3-1 | |
| » W: Nolan Ryan (1-0) L: John Dopson (0-1) S: Tom Henke (2) | First | -- |
| Saturday, April 10 |
| » Defeated Rangers (3-1), 10-2 | Arlington Stadium (1-1) | 4-1 | |
| » W: Roger Clemens (2-0) L: Craig Lefferts (1-1) | First | -- |
| » Major-league debuts: Robb Nen (Rangers) |
| Sunday, April 11 |
| » Lost to Rangers (4-1), 4-1 | Arlington Stadium (1-2) | 4-2 | |
| » W: Kevin Brown (1-0) L: Danny Darwin (0-1) S: Tom Henke (3) | First | -- |
| Tuesday, April 13 |
| » Defeated Indians (3-4), 6-2 | Fenway Park (1-0) | 5-2 | |
| » W: Frank Viola (2-0) L: Jeff Mutis (0-1) | First | -- |
| Wednesday, April 14 |
| » Defeated Indians (3-5), 12-7 | Fenway Park (2-0) | 6-2 | Won 2 |
| » W: Joe Hesketh (1-0) L: Mike Bielecki (1-1) | First | -- |
| Thursday, April 15 |
| » Defeated Indians (3-6), 4-3 | Fenway Park (3-0) | 7-2 | Won 3 |
| » W: Paul Quantrill (1-0) L: Eric Plunk (1-1) | First | -- |
| Friday, April 16 |
| » Lost to White Sox (5-4), 9-4 | Fenway Park (3-1) | 7-3 | |
| » W: Jack McDowell (3-0) L: Danny Darwin (0-2) | First | -- |
| Saturday, April 17 |
| » Defeated White Sox (5-5), 5-1 | Fenway Park (4-1) | 8-3 | |
| » W: Joe Hesketh (2-0) L: Kirk McCaskill (0-3) | First | -- |
| Sunday, April 18 |
| » Defeated White Sox (5-6), 4-0 | Fenway Park (5-1) | 9-3 | Won 2 |
| » W: Frank Viola (3-0) L: Rodney Bolton (0-2) | First | -- |
| Monday, April 19 |
| » Defeated White Sox (5-7), 6-0 | Fenway Park (6-1) | 10-3 | Won 3 |
| » W: John Dopson (1-1) L: Alex Fernandez (2-1) | First | -- |
| Tuesday, April 20 |
| » Defeated Mariners (5-8), 5-2 | Kingdome (1-0) | 11-3 | Won 4 |
| » W: Roger Clemens (3-0) L: John Cummings (0-3) S: Jeff Russell (3) | First | -- |
| Wednesday, April 21 |
| » Lost to Mariners (6-8), 5-0 | Kingdome (1-1) | 11-4 | |
| » W: Randy Johnson (2-1) L: Danny Darwin (0-3) | First | -- |
| Thursday, April 22 |
| » Lost to Mariners (7-8), 7-0 | Kingdome (1-2) | 11-5 | Lost 2 |
| » W: Chris Bosio (1-1) L: Joe Hesketh (2-1) | First | -- |
| Friday, April 23 |
| » Lost to Angels (10-4), 4-1 | Anaheim Stadium (0-1) | 11-6 | Lost 3 |
| » W: Mark Langston (2-0) L: Frank Viola (3-1) | Second | 1 out |
| Saturday, April 24 |
| » Lost to Angels (11-4), 8-5 | Anaheim Stadium (0-2) | 11-7 | Lost 4 |
| » W: Chuck Crim (2-0) L: Scott Bankhead (1-1) S: Julio Valera (2) | Second | 1 out |
| Sunday, April 25 |
| » Lost to Angels (12-4), 2-1 | Anaheim Stadium (0-3) | 11-8 | Lost 5 |
| » W: Scott Sanderson (3-0) L: Roger Clemens (3-1) S: Joe Grahe (2) | Second | 2 out |
| Tuesday, April 27 |
| » Lost to Athletics (6-10), 7-2 | Oakland-Alameda County Stadium (0-1) | 11-9 | Lost 6 |
| » W: Bobby Witt (1-0) L: Danny Darwin (0-4) S: Rich Gossage (1) | Fourth | 2½ out |
| Wednesday, April 28 |
| » Defeated Athletics (6-11), 3-1 | Oakland-Alameda County Stadium (1-1) | 12-9 | |
| » W: Frank Viola (4-1) L: Bob Welch (2-2) S: Jeff Russell (4) | Second | 1½ out |
| Friday, April 30 |
| » Defeated Angels (13-6), 6-1 | Fenway Park (7-1) | 13-9 | Won 2 |
| » W: John Dopson (2-1) L: John Farrell (1-3) | Second | 2 out |
| Saturday, May 1 |
| » Defeated Angels (13-7), 3-1 | Fenway Park (8-1) | 14-9 | Won 3 |
| » W: Roger Clemens (4-1) L: Scott Sanderson (3-1) S: Jeff Russell (5) | Second | 1 out |
| Sunday, May 2 |
| » Defeated Angels (13-8), 4-3 | Fenway Park (9-1) | 15-9 | Won 4 |
| » W: Danny Darwin (1-4) L: Chuck Finley (2-2) S: Jeff Russell (6) | First | -- |
| Monday, May 3 |
| » Lost to Mariners (12-13), 2-0 | Fenway Park (9-2) | 15-10 | |
| » W: Erik Hanson (4-0) L: Frank Viola (4-2) S: Norm Charlton (4) | Second | ½ out |
| Tuesday, May 4 |
| » Lost to Mariners (13-13), 7-6 | Fenway Park (9-3) | 15-11 | Lost 2 |
| » W: Tim Leary (1-1) L: Joe Hesketh (2-2) S: Norm Charlton (5) | Third | 1½ out |
| Wednesday, May 5 |
| » Defeated Athletics (8-15), 3-1 | Fenway Park (10-3) | 16-11 | |
| » W: Paul Quantrill (2-0) L: Edwin Nunez (0-1) S: Jeff Russell (7) | Second | ½ out |
| » Major-league debuts: Brent Gates (Athletics) |
| Thursday, May 6 |
| » Lost to Athletics (9-15), 6-3 | Fenway Park (10-4) | 16-12 | |
| » W: Bobby Witt (2-1) L: Roger Clemens (4-2) S: Dennis Eckersley (4) | Second | 1 out |
| Friday, May 7 |
| » Defeated Brewers (11-15), 1-0 | County Stadium (1-0) | 17-12 | |
| » W: Danny Darwin (2-4) L: Bill Wegman (2-5) S: Jeff Russell (8) | Second | 1 out |
| Saturday, May 8 |
| » Lost to Brewers (12-15), 6-3 | County Stadium (1-1) | 17-13 | |
| » W: Cal Eldred (4-3) L: Paul Quantrill (2-1) S: Doug Henry (6) | Second | 1 out |
| Sunday, May 9 |
| » Lost to Brewers (13-15), 6-0 | County Stadium (1-2) | 17-14 | Lost 2 |
| » W: Mike Boddicker (2-1) L: Joe Hesketh (2-3) | Third | 1 out |
| » Major-league debuts: Troy O'Leary (Brewers) |
| Monday, May 10 |
| » Lost to Orioles (13-17), 2-1 | Oriole Park at Camden Yards (0-1) | 17-15 | Lost 3 |
| » W: Todd Frohwirth (2-2) L: Paul Quantrill (2-2) S: Brad Pennington (1) | Third | 2 out |
| Tuesday, May 11 |
| » Defeated Orioles (13-18), 4-0 | Oriole Park at Camden Yards (1-1) | 18-15 | |
| » W: Roger Clemens (5-2) L: Ben McDonald (2-4) | Third | 2 out |
| Wednesday, May 12 |
| » Defeated Orioles (13-19), 2-0 | Oriole Park at Camden Yards (2-1) | 19-15 | Won 2 |
| » W: Danny Darwin (3-4) L: Fernando Valenzuela (0-3) S: Jeff Russell (9) | Second | 2 out |
| Friday, May 14 |
| » Lost to Twins (15-18), 4-3 | Hubert H. Humphrey Metrodome (0-1) | 19-16 | |
| » W: Scott Erickson (2-4) L: Frank Viola (4-3) S: Rick Aguilera (11) | Second | 2½ out |
| Saturday, May 15 |
| » Lost to Twins (16-18), 7-4 | Hubert H. Humphrey Metrodome (0-2) | 19-17 | Lost 2 |
| » W: Jim Deshaies (5-2) L: John Dopson (2-2) S: Rick Aguilera (12) | Third | 3½ out |
| Sunday, May 16 |
| » Defeated Twins (16-19), 11-5 | Hubert H. Humphrey Metrodome (1-2) | 20-17 | |
| » W: Joe Hesketh (3-3) L: Mike Hartley (0-2) | Second | 2½ out |
| Monday, May 17 |
| » Lost to Blue Jays (20-18), 9-3 | Fenway Park (10-5) | 20-18 | |
| » W: Pat Hentgen (5-2) L: Roger Clemens (5-3) | Third | 3 out |
| Tuesday, May 18 |
| » Major-league debuts: Scott Lydy (Athletics) |
| Wednesday, May 19 |
| » Defeated Blue Jays (20-19), 10-5 | Fenway Park (11-5) | 21-18 | |
| » W: Danny Darwin (4-4) L: Dave Stewart (0-1) | Third | 3½ out |
| » Major-league debuts: Domingo Cedeno (Blue Jays) |
| Thursday, May 20 |
| » Lost to Blue Jays (21-19), 4-3 | Fenway Park (11-6) | 21-19 | |
| » W: Danny Cox (3-0) L: Paul Quantrill (2-3) S: Duane Ward (10) | Third | 4½ out |
| Friday, May 21 |
| » Defeated Yankees (23-18), 7-2 | Fenway Park (12-6) | 22-19 | |
| » W: John Dopson (3-2) L: Melido Perez (2-3) | Third | 3½ out |
| Saturday, May 22 |
| » Lost to Yankees (24-18), 7-3 | Fenway Park (12-7) | 22-20 | |
| » W: Mike Witt (3-1) L: Roger Clemens (5-4) | Fourth | 4½ out |
| Sunday, May 23 |
| » Defeated Yankees (24-19), 5-2 | Fenway Park (13-7) | 23-20 | |
| » W: Greg Harris (1-0) L: Jimmy Key (4-2) S: Jeff Russell (10) | Third | 4½ out |
| Monday, May 24 |
| » Defeated Tigers (27-16), 6-5 | Tiger Stadium (1-0) | 24-20 | Won 2 |
| » W: Ken Ryan (1-0) L: Rob MacDonald (3-2) S: Jeff Russell (11) | Third | 3½ out |
| Tuesday, May 25 |
| » Lost to Tigers (28-16), 4-1 | Tiger Stadium (1-1) | 24-21 | |
| » W: David Wells (6-1) L: Frank Viola (4-4) S: Mike Henneman (10) | Fourth | 4½ out |
| Wednesday, May 26 |
| » Lost to Tigers (29-16), 4-2 | Tiger Stadium (1-2) | 24-22 | Lost 2 |
| » W: Bill Gullickson (2-1) L: John Dopson (3-3) S: Kurt Knudsen (1) | Fourth | 5½ out |
| Thursday, May 27 |
| » Major-league debuts: Jason Bere (White Sox) |
| Friday, May 28 |
| » Defeated Rangers (24-22), 4-1 | Fenway Park (14-7) | 25-22 | |
| » W: Roger Clemens (6-4) L: Roger Pavlik (1-1) S: Jeff Russell (12) | Third | 4½ out |
| Saturday, May 29 |
| » Defeated Rangers (24-23), 15-1 | Fenway Park (15-7) | 26-22 | Won 2 |
| » W: Danny Darwin (5-4) L: Todd Burns (0-2) | Third | 4½ out |
| Sunday, May 30 |
| » Defeated Rangers (24-24), 6-5 | Fenway Park (16-7) | 27-22 | Won 3 |
| » W: Jose Melendez (1-0) L: Jeff Bronkey (0-1) | Third | 3½ out |
| Monday, May 31 |
| » Lost to Royals (25-23), 5-3 | Fenway Park (16-8) | 27-23 | |
| » W: David Cone (3-5) L: John Dopson (3-4) S: Jeff Montgomery (16) | Third | 4 out |
| Tuesday, June 1 |
| » Lost to Royals (26-23), 4-3 | Fenway Park (16-9) | 27-24 | Lost 2 |
| » W: Chris Haney (3-0) L: Paul Quantrill (2-4) S: Jeff Montgomery (17) | Fourth | 4 out |
| Wednesday, June 2 |
| » Lost to Royals (27-23), 7-2 | Fenway Park (16-10) | 27-25 | Lost 3 |
| » W: Kevin Appier (6-4) L: Roger Clemens (6-5) | Fourth | 4 out |
| Friday, June 4 |
| » Defeated White Sox (26-25), 1-0 | Comiskey Park II (1-0) | 28-25 | |
| » W: Greg Harris (2-0) L: Roberto Hernandez (1-2) S: Jeff Russell (13) | Fourth | 3½ out |
| Former Red Sox Bobby Reeves dies in Chattanooga, TN at the age of 89. |
| Saturday, June 5 |
| » Lost to White Sox (27-25), 11-3 | Comiskey Park II (1-1) | 28-26 | |
| » W: Jack McDowell (8-4) L: Frank Viola (4-5) | Fourth | 4½ out |
| Sunday, June 6 |
| » Lost to White Sox (28-25), 4-3 | Comiskey Park II (1-2) | 28-27 | Lost 2 |
| » W: Alex Fernandez (7-3) L: Jose Melendez (1-1) S: Roberto Hernandez (10) | Fourth | 5½ out |
| Tuesday, June 8 |
| » Lost to Indians (22-35), 5-4 | Cleveland Stadium (0-1) | 28-28 | Lost 3 |
| » W: Derek Lilliquist (2-1) L: Greg Harris (2-1) | Fourth | 6 out |
| Wednesday, June 9 |
| » Lost to Indians (23-35), 3-2 | Cleveland Stadium (0-2) | 28-29 | Lost 4 |
| » W: Cliff Young (2-2) L: Danny Darwin (5-5) S: Eric Plunk (4) | Fourth | 7 out |
| Thursday, June 10 |
| » Lost to Orioles (29-30), 2-1 | Fenway Park (16-11) | 28-30 | Lost 5 |
| » W: Jamie Moyer (1-3) L: Frank Viola (4-6) S: Gregg Olson (16) | Fifth | 8 out |
| Friday, June 11 |
| » Lost to Orioles (30-30), 16-4 | Fenway Park (16-12) | 28-31 | Lost 6 |
| » W: Mike Mussina (9-2) L: John Dopson (3-5) | Fifth | 9 out |
| Saturday, June 12 |
| » Lost to Orioles (31-30), 5-1 | Fenway Park (16-13) | 28-32 | Lost 7 |
| » W: Brad Pennington (3-1) L: Greg Harris (2-2) | Fifth | 10 out |
| Sunday, June 13 |
| » Defeated Orioles (31-31), 4-2 | Fenway Park (17-13) | 29-32 | |
| » W: Roger Clemens (7-5) L: Fernando Valenzuela (2-6) S: Jeff Russell (14) | Fifth | 9 out |
| Monday, June 14 |
| » Lost to Yankees (36-28), 4-0 | Yankee Stadium (0-1) | 29-33 | |
| » W: Scott Kamieniecki (1-1) L: Danny Darwin (5-6) | Fourth | 10 out |
| Tuesday, June 15 |
| » Lost to Yankees (37-28), 9-7 | Yankee Stadium (0-2) | 29-34 | Lost 2 |
| » W: Neal Heaton (1-0) L: Frank Viola (4-7) S: Steve Farr (16) | Fourth | 11 out |
| Wednesday, June 16 |
| » Defeated Yankees (37-29), 7-1 | Yankee Stadium (1-2) | 30-34 | |
| » W: John Dopson (4-5) L: Melido Perez (4-6) | Fifth | 10 out |
| Thursday, June 17 |
| » Lost to Blue Jays (39-28), 7-0 | Skydome (0-1) | 30-35 | |
| » W: Al Leiter (4-5) L: Paul Quantrill (2-5) | Fifth | 11 out |
| Friday, June 18 |
| » Lost to Blue Jays (40-28), 11-2 | Skydome (0-2) | 30-36 | Lost 2 |
| » W: Pat Hentgen (9-2) L: Roger Clemens (7-6) | Fifth | 11 out |
| Saturday, June 19 |
| » Lost to Blue Jays (41-28), 9-4 | Skydome (0-3) | 30-37 | Lost 3 |
| » W: Dave Stewart (3-2) L: Danny Darwin (5-7) | Fifth | 12 out |
| Sunday, June 20 |
| » Lost to Blue Jays (42-28), 3-2 | Skydome (0-4) | 30-38 | Lost 4 |
| » W: Mike Timlin (1-1) L: Jeff Russell (0-1) | Fifth | 13 out |
| Monday, June 21 |
| » Defeated Twins (29-37), 6-3 | Fenway Park (18-13) | 31-38 | |
| » W: John Dopson (5-5) L: Scott Erickson (3-8) S: Jeff Russell (15) | Fifth | 12½ out |
| Tuesday, June 22 |
| » Defeated Twins (29-38), 4-1 | Fenway Park (19-13) | 32-38 | Won 2 |
| » W: Paul Quantrill (3-5) L: Jim Deshaies (8-5) S: Jeff Russell (16) | Fifth | 11½ out |
| Wednesday, June 23 |
| » Defeated Twins (29-39), 3-1 | Fenway Park (20-13) | 33-38 | Won 3 |
| » W: Aaron Sele (1-0) L: Eddie Guardado (0-2) S: Greg Harris (1) | Fifth | 10½ out |
| » Major-league debuts: Aaron Sele (Red Sox) |
| Friday, June 25 |
| » Defeated Tigers (43-29), 8-2 | Fenway Park (21-13) | 34-38 | Won 4 |
| » W: Danny Darwin (6-7) L: David Wells (9-2) S: Greg Harris (2) | Fifth | 9 out |
| Saturday, June 26 |
| » Defeated Tigers (43-30), 13-4 | Fenway Park (22-13) | 35-38 | Won 5 |
| » W: Jose Melendez (2-1) L: John Doherty (7-3) | Fifth | 9 out |
| Sunday, June 27 |
| » Defeated Tigers (43-31), 8-2 | Fenway Park (23-13) | 36-38 | Won 6 |
| » W: John Dopson (6-5) L: Bill Gullickson (4-4) | Fifth | 9 out |
| Monday, June 28 |
| » Defeated Brewers (31-43), 4-3 | Fenway Park (24-13) | 37-38 | Won 7 |
| » W: Greg Harris (3-2) L: Doug Henry (0-2) | Fifth | 9 out |
| Tuesday, June 29 |
| » Lost to Brewers (32-43), 7-6 | Fenway Park (24-14) | 37-39 | |
| » W: Mike Fetters (2-0) L: Greg Harris (3-3) S: Doug Henry (14) | Fifth | 10 out |
| Wednesday, June 30 |
| » Defeated Brewers (32-44), 12-2 | Fenway Park (25-14) | 38-39 | |
| » W: Danny Darwin (7-7) L: Angel Miranda (0-1) | Fifth | 9 out |
| Friday, July 2 |
| » Defeated Mariners (39-41), 9-8 | Kingdome (2-2) | 39-39 | Won 2 |
| » W: Frank Viola (5-7) L: Mike Hampton (1-3) S: Jeff Russell (17) | Fifth | 8 out |
| Saturday, July 3 |
| » Defeated Mariners (39-42), 6-5 | Kingdome (3-2) | 40-39 | Won 3 |
| » W: Greg Harris (4-3) L: Norm Charlton (1-2) S: Jeff Russell (18) | Fifth | 7 out |
| Sunday, July 4 |
| » Defeated Mariners (39-43), 6-0 | Kingdome (4-2) | 41-39 | Won 4 |
| » W: Paul Quantrill (4-5) L: Chris Bosio (2-4) | Fifth | 6 out |
| » Major-league debuts: Brad Holman (Mariners) |
| Monday, July 5 |
| » Defeated Angels (38-42), 4-3 | Anaheim Stadium (1-3) | 42-39 | Won 5 |
| » W: Ken Ryan (2-0) L: Gene Nelson (0-2) | Fifth | 5 out |
| Tuesday, July 6 |
| » Lost to Angels (39-42), 3-2 | Anaheim Stadium (1-4) | 42-40 | |
| » W: Chuck Finley (10-6) L: Joe Hesketh (3-4) | Fifth | 6 out |
| Wednesday, July 7 |
| » Lost to Angels (40-42), 7-6 | Anaheim Stadium (1-5) | 42-41 | Lost 2 |
| » W: Doug Linton (1-1) L: Jeff Russell (0-2) | Fifth | 6 out |
| Former Red Sox Ben Chapman dies in Hoover, AL at the age of 85. |
| Thursday, July 8 |
| » Defeated Athletics (37-44), 11-9 | Oakland-Alameda County Stadium (2-1) | 43-41 | |
| » W: John Dopson (7-5) L: Todd VanPoppel (0-1) S: Jeff Russell (19) | Fifth | 5 out |
| Friday, July 9 |
| » Lost to Athletics (38-44), 4-2 | Oakland-Alameda County Stadium (2-2) | 43-42 | |
| » W: Ron Darling (2-4) L: Paul Quantrill (4-6) S: Dennis Eckersley (21) | Fifth | 5 out |
| Saturday, July 10 |
| » Defeated Athletics (38-45), 5-0 | Oakland-Alameda County Stadium (3-2) | 44-42 | |
| » W: Aaron Sele (2-0) L: Kelly Downs (2-3) S: Greg Harris (3) | Fifth | 4 out |
| Sunday, July 11 |
| » Defeated Athletics (38-46), 3-2 | Oakland-Alameda County Stadium (4-2) | 45-42 | Won 2 |
| » W: Danny Darwin (8-7) L: Bobby Witt (8-6) S: Jeff Russell (20) | Fifth | 3 out |
| Thursday, July 15 |
| » Lost to Mariners (45-44), 3-2 | Fenway Park (25-15) | 45-43 | |
| » W: Dave Fleming (5-1) L: Frank Viola (5-8) S: Mike Hampton (1) | Fourth | 4 out |
| Friday, July 16 |
| » Defeated Mariners (45-45), 5-3 | Fenway Park (26-15) | 46-43 | |
| » W: Roger Clemens (8-6) L: Erik Hanson (7-7) S: Jeff Russell (21) | Fifth | 3 out |
| Saturday, July 17 |
| » Defeated Mariners (45-46), 4-3 | Fenway Park (27-15) | 47-43 | Won 2 |
| » W: Danny Darwin (9-7) L: Chris Bosio (3-5) S: Jeff Russell (22) | Third | 2 out |
| Sunday, July 18 |
| » Defeated Mariners (45-47), 7-6 | Fenway Park (28-15) | 48-43 | Won 3 |
| » W: Ken Ryan (3-0) L: Norm Charlton (1-3) S: Greg Harris (4) | Third | 2 out |
| Monday, July 19 |
| » Defeated Angels (44-47), 8-6 | Fenway Park (29-15) | 49-43 | Won 4 |
| » W: Aaron Sele (3-0) L: Scott Sanderson (7-10) S: Jeff Russell (23) | Fourth | 2 out |
| Tuesday, July 20 |
| » Defeated Angels (44-48), 2-1 | Fenway Park (30-15) | 50-43 | Won 5 |
| » W: Tony Fossas (1-0) L: Gene Nelson (0-3) | Third | 1½ out |
| Wednesday, July 21 |
| » Defeated Angels (44-49), 4-1 | Fenway Park (31-15) | 51-43 | Won 6 |
| » W: Roger Clemens (9-6) L: Chuck Finley (11-7) S: Jeff Russell (24) | Third | 1 out |
| Thursday, July 22 |
| » Defeated Athletics (40-52), 9-7 | Fenway Park (32-15) | 52-43 | Won 7 |
| » W: Ken Ryan (4-0) L: Edwin Nunez (3-5) S: Jeff Russell (25) | Second | 1 out |
| Friday, July 23 |
| » Defeated Athletics (40-53), 6-5 | Fenway Park (33-15) | 53-43 | Won 8 |
| » W: Greg Harris (5-3) L: Rich Gossage (4-5) | First | -- |
| Saturday, July 24 |
| » Defeated Athletics (40-54), 5-3 | Fenway Park (34-15) | 54-43 | Won 9 |
| » W: Aaron Sele (4-0) L: Kelly Downs (2-5) S: Jeff Russell (26) | First | -- |
| Sunday, July 25 |
| » Defeated Athletics (40-55), 8-1 | Fenway Park (35-15) | 55-43 | Won 10 |
| » W: Frank Viola (6-8) L: Bob Welch (7-7) S: Paul Quantrill (1) | First | -- |
| Monday, July 26 |
| » Lost to Brewers (40-57), 3-2 | County Stadium (1-3) | 55-44 | |
| » W: Graeme Lloyd (3-1) L: Jeff Russell (0-3) | Second | ½ out |
| Tuesday, July 27 |
| » Lost to Brewers (41-57), 3-2 | County Stadium (1-4) | 55-45 | Lost 2 |
| » W: Jaime Navarro (6-8) L: Danny Darwin (9-8) S: Jesse Orosco (2) | Third | 1½ out |
| Wednesday, July 28 |
| » Defeated Brewers (41-58), 8-4 | County Stadium (2-4) | 56-45 | |
| » W: Greg Harris (6-3) L: Angel Miranda (0-2) | Third | 1½ out |
| Thursday, July 29 |
| » Defeated Brewers (41-59), 7-3 | County Stadium (3-4) | 57-45 | Won 2 |
| » W: Aaron Sele (5-0) L: Ricky Bones (6-7) | Third | 1½ out |
| Friday, July 30 |
| » Defeated Orioles (54-48), 8-7 | Oriole Park at Camden Yards (3-1) | 58-45 | Won 3 |
| » W: Paul Quantrill (5-6) L: Jamie Moyer (7-5) S: Jeff Russell (27) | Second | ½ out |
| Saturday, July 31 |
| » Lost to Orioles (55-48), 4-0 | Oriole Park at Camden Yards (3-2) | 58-46 | |
| » W: Ben McDonald (8-9) L: Roger Clemens (9-7) | Second | 1½ out |
| Former Red Sox Sam Langford dies in Plainview, TX at the age of 95. |
| Sunday, August 1 |
| » Defeated Orioles (55-49), 2-1 | Oriole Park at Camden Yards (4-2) | 59-46 | |
| » W: Danny Darwin (10-8) L: Rick Sutcliffe (8-7) S: Jeff Russell (28) | Third | 1½ out |
| Tuesday, August 3 |
| » Lost to Twins (45-58), 6-1 | Hubert H. Humphrey Metrodome (1-3) | 59-47 | |
| » W: Willie Banks (8-7) L: John Dopson (7-6) | Second | 3 out |
| Wednesday, August 4 |
| » Defeated Twins (45-59), 5-4 | Hubert H. Humphrey Metrodome (2-3) | 60-47 | |
| » W: Aaron Sele (6-0) L: Scott Erickson (6-13) S: Jeff Russell (29) | Second | 2 out |
| Thursday, August 5 |
| » Defeated Twins (45-60), 2-1 | Hubert H. Humphrey Metrodome (3-3) | 61-47 | Won 2 |
| » W: Frank Viola (7-8) L: Jim Deshaies (11-9) S: Jeff Russell (30) | Second | 1 out |
| Friday, August 6 |
| » Lost to Tigers (55-55), 5-1 | Tiger Stadium (1-3) | 61-48 | |
| » W: Bill Gullickson (7-6) L: Roger Clemens (9-8) | Second | 2 out |
| Former Red Sox Tex Hughson dies in San Marcos, TX at the age of 78. |
| Saturday, August 7 |
| » Defeated Tigers (55-56), 4-1 | Tiger Stadium (2-3) | 62-48 | |
| » W: Danny Darwin (11-8) L: Sean Bergman (1-4) S: Jeff Russell (31) | Second | 1 out |
| Sunday, August 8 |
| » Lost to Tigers (56-56), 5-1 | Tiger Stadium (2-4) | 62-49 | |
| » W: Tom Bolton (2-4) L: John Dopson (7-7) | Second | 1 out |
| Tuesday, August 10 |
| » Defeated Yankees (63-51), 5-0 | Fenway Park (36-15) | 63-49 | |
| » W: Frank Viola (8-8) L: Scott Kamieniecki (7-4) S: Joe Hesketh (1) | Second | 1 out |
| Wednesday, August 11 |
| » Lost to Yankees (64-51), 8-3 | Fenway Park (36-16) | 63-50 | |
| » W: Jimmy Key (14-4) L: Roger Clemens (9-9) S: Bob Wickman (1) | Second | 2 out |
| Thursday, August 12 |
| » Lost to Yankees (65-51), 4-1 | Fenway Park (36-17) | 63-51 | Lost 2 |
| » W: Melido Perez (6-10) L: Aaron Sele (6-1) S: Steve Farr (22) | Third | 2 out |
| Friday, August 13 |
| » Defeated Blue Jays (66-51), 5-3 | Fenway Park (37-17) | 64-51 | |
| » W: Danny Darwin (12-8) L: Todd Stottlemyre (6-9) S: Jeff Russell (32) | Second | 1 out |
| Saturday, August 14 |
| » Lost to Blue Jays (67-51), 5-2 | Fenway Park (37-18) | 64-52 | |
| » W: Pat Hentgen (14-6) L: John Dopson (7-8) S: Duane Ward (31) | Second | 2 out |
| Sunday, August 15 |
| » Lost to Blue Jays (68-51), 9-1 | Fenway Park (37-19) | 64-53 | Lost 2 |
| » W: Dave Stewart (8-6) L: Roger Clemens (9-10) | Second | 3 out |
| Tuesday, August 17 |
| » Lost to White Sox (65-53), 3-2 | Fenway Park (37-20) | 64-54 | Lost 3 |
| » W: Jack McDowell (19-7) L: Aaron Sele (6-2) S: Roberto Hernandez (26) | Third | 4½ out |
| Wednesday, August 18 |
| » Defeated White Sox (65-54), 5-0 | Fenway Park (38-20) | 65-54 | |
| » W: Danny Darwin (13-8) L: Jason Bere (5-5) | Third | 4½ out |
| Thursday, August 19 |
| » Lost to Indians (56-65), 5-1 | Fenway Park (38-21) | 65-55 | |
| » W: Julian Tavarez (2-1) L: Paul Quantrill (5-7) | Third | 5 out |
| Friday, August 20 |
| » Lost to Indians (57-65), 7-6 | Fenway Park (38-22) | 65-56 | Lost 2 |
| » W: Jerry Dipoto (4-2) L: Jeff Russell (0-4) | Third | 5 out |
| Saturday, August 21 |
| » Lost to Indians (58-65), 10-5 | Fenway Park (38-23) | 65-57 | Lost 3 |
| » W: Bill Wertz (2-1) L: Greg Harris (6-4) | Third | 5 out |
| Sunday, August 22 |
| » Lost to Indians (59-65), 3-2 | Fenway Park (38-24) | 65-58 | Lost 4 |
| » W: Tom Kramer (6-3) L: Ken Ryan (4-1) S: Jerry Dipoto (3) | Fourth | 6 out |
| Tuesday, August 24 |
| » Lost to Rangers (65-60), 4-3 | Arlington Stadium (1-3) | 65-59 | Lost 5 |
| » W: Roger Pavlik (8-6) L: Danny Darwin (13-9) S: Tom Henke (30) | Fourth | 6½ out |
| Wednesday, August 25 |
| » Lost to Rangers (66-60), 10-2 | Arlington Stadium (1-4) | 65-60 | Lost 6 |
| » W: Steve Dreyer (2-1) L: Paul Quantrill (5-8) | Fifth | 7½ out |
| Thursday, August 26 |
| » Defeated Rangers (66-61), 3-1 | Arlington Stadium (2-4) | 66-60 | |
| » W: Frank Viola (9-8) L: Kevin Brown (10-10) S: Jeff Russell (33) | Fourth | 6½ out |
| Friday, August 27 |
| » Defeated Royals (67-62), 5-0 | Royals Stadium (4-0) | 67-60 | Won 2 |
| » W: Roger Clemens (10-10) L: Chris Haney (9-6) | Third | 5½ out |
| Saturday, August 28 |
| » Defeated Royals (67-63), 2-1 | Royals Stadium (5-0) | 68-60 | Won 3 |
| » W: Jeff Russell (1-4) L: Jeff Montgomery (3-5) | Third | 4½ out |
| Sunday, August 29 |
| » Lost to Royals (68-63), 5-4 | Royals Stadium (5-1) | 68-61 | |
| » W: Mark Gubicza (4-6) L: John Dopson (7-9) | Fourth | 5½ out |
| Monday, August 30 |
| » Defeated Rangers (68-63), 7-3 | Fenway Park (39-24) | 69-61 | |
| » W: Frank Viola (10-8) L: Kevin Brown (10-11) | Fourth | 5½ out |
| Tuesday, August 31 |
| » Lost to Rangers (69-63), 8-1 | Fenway Park (39-25) | 69-62 | |
| » W: Kenny Rogers (14-7) L: Roger Clemens (10-11) | Fifth | 6½ out |
| » Major-league debuts: Luis Ortiz (Red Sox) |
| Wednesday, September 1 |
| » Lost to Rangers (70-63), 9-7 | Fenway Park (39-26) | 69-63 | Lost 2 |
| » W: Jeff Bronkey (1-1) L: Paul Quantrill (5-9) | Fifth | 7½ out |
| » Major-league debuts: Cory Bailey (Red Sox) Darren Oliver (Rangers) |
| Friday, September 3 |
| » Lost to Royals (70-65), 5-1 | Fenway Park (39-27) | 69-64 | Lost 3 |
| » W: Kevin Appier (15-6) L: Danny Darwin (13-10) | Fifth | 7½ out |
| Saturday, September 4 |
| » Lost to Royals (71-65), 4-2 | Fenway Park (39-28) | 69-65 | Lost 4 |
| » W: David Cone (11-11) L: Ken Ryan (4-2) S: Jeff Montgomery (42) | Fifth | 7½ out |
| Sunday, September 5 |
| » Lost to Royals (72-65), 5-2 | Fenway Park (39-29) | 69-66 | Lost 5 |
| » W: Tom Gordon (9-6) L: Roger Clemens (10-12) | Fourth | 7½ out |
| » Major-league debuts: Greg Blosser and Jeff McNeely (Red Sox) |
| Monday, September 6 |
| » Defeated White Sox (78-59), 3-1 | Comiskey Park II (2-2) | 70-66 | |
| » W: Scott Bankhead (2-1) L: Jack McDowell (21-8) S: Greg Harris (5) | Fourth | 7 out |
| Tuesday, September 7 |
| » Defeated White Sox (78-60), 4-3 | Comiskey Park II (3-2) | 71-66 | Won 2 |
| » W: Danny Darwin (14-10) L: Tim Belcher (12-10) S: Ken Ryan (1) | Fifth | 6 out |
| Wednesday, September 8 |
| » Lost to White Sox (79-60), 8-1 | Comiskey Park II (3-3) | 71-67 | |
| » W: Jason Bere (8-5) L: John Dopson (7-10) | Fifth | 6 out |
| Friday, September 10 |
| » Lost to Indians (67-74), 7-4 | Cleveland Stadium (0-3) | 71-68 | Lost 2 |
| » W: Bob Ojeda (2-1) L: Roger Clemens (10-13) S: Jerry Dipoto (7) | Fifth | 6 out |
| » Defeated Indians (67-75), 5-4 | Cleveland Stadium (1-3) | 72-68 | |
| » W: Ken Ryan (5-2) L: Bill Wertz (2-3) | Fifth | 6 out |
| » Major-league debuts: Brian Anderson (Indians) |
| Saturday, September 11 |
| » Lost to Indians (68-75), 9-3 | Cleveland Stadium (1-4) | 72-69 | |
| » W: Derek Lilliquist (4-3) L: Paul Quantrill (5-10) | Fifth | 7 out |
| Sunday, September 12 |
| » Defeated Indians (68-76), 11-1 | Cleveland Stadium (2-4) | 73-69 | |
| » W: Nate Minchey (1-0) L: Jason Grimsley (1-4) | Fifth | 7 out |
| » Major-league debuts: Nate Minchey (Red Sox) |
| Monday, September 13 |
| » Defeated Orioles (79-65), 6-4 | Fenway Park (40-29) | 74-69 | Won 2 |
| » W: Paul Quantrill (6-10) L: Mark Williamson (7-5) S: Greg Harris (6) | Fifth | 6½ out |
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