| Thursday, January 28 |
| Former Indian Vern Kennedy dies in Mendon, MO at the age of 86. |
| Monday, March 22 |
| Former Indian Steve Olin dies in Little Lake Nellie, FL at the age of 28. |
| Monday, April 5 |
| » Lost to Yankees (1-0), 9-1 | Cleveland Stadium (0-1) | 0-1 | |
| » W: Jimmy Key (1-0) L: Charles Nagy (0-1) | Third | 1 out |
| Wednesday, April 7 |
| » Defeated Yankees (1-1), 4-2 | Cleveland Stadium (1-1) | 1-1 | |
| » W: Eric Plunk (1-0) L: Jim Abbott (0-1) S: Derek Lilliquist (1) | Second | 1 out |
| Thursday, April 8 |
| » Defeated Yankees (1-2), 15-5 | Cleveland Stadium (2-1) | 2-1 | Won 2 |
| » W: Mike Bielecki (1-0) L: Sam Militello (0-1) | Second | 1 out |
| Friday, April 9 |
| » Lost to Blue Jays (2-1), 13-10 | Skydome (0-1) | 2-2 | |
| » W: Mark Eichhorn (1-0) L: Ted Power (0-1) S: Duane Ward (2) | Third | 1 out |
| Saturday, April 10 |
| » Lost to Blue Jays (3-1), 5-4 | Skydome (0-2) | 2-3 | Lost 2 |
| » W: Todd Stottlemyre (1-0) L: Charles Nagy (0-2) S: Duane Ward (3) | Fifth | 2 out |
| Sunday, April 11 |
| » Defeated Blue Jays (3-2), 10-6 | Skydome (1-2) | 3-3 | |
| » W: Mark Clark (1-0) L: Jack Morris (0-2) S: Derek Lilliquist (2) | Third | 1 out |
| Tuesday, April 13 |
| » Lost to Red Sox (5-2), 6-2 | Fenway Park (0-1) | 3-4 | |
| » W: Frank Viola (2-0) L: Jeff Mutis (0-1) | Fourth | 2 out |
| Wednesday, April 14 |
| » Lost to Red Sox (6-2), 12-7 | Fenway Park (0-2) | 3-5 | Lost 2 |
| » W: Joe Hesketh (1-0) L: Mike Bielecki (1-1) | Fifth | 3 out |
| Thursday, April 15 |
| » Lost to Red Sox (7-2), 4-3 | Fenway Park (0-3) | 3-6 | Lost 3 |
| » W: Paul Quantrill (1-0) L: Eric Plunk (1-1) | Fifth | 4 out |
| Friday, April 16 |
| » Defeated Blue Jays (5-4), 13-1 | Cleveland Stadium (3-1) | 4-6 | |
| » W: Charles Nagy (1-2) L: Jack Morris (0-3) | Fourth | 3 out |
| » Major-league debuts: Willie Canate (Blue Jays) |
| Saturday, April 17 |
| » Lost to Blue Jays (6-4), 8-1 | Cleveland Stadium (3-2) | 4-7 | |
| » W: Pat Hentgen (1-1) L: Mark Clark (1-1) | Fifth | 4 out |
| Sunday, April 18 |
| » Defeated Blue Jays (6-5), 6-5 | Cleveland Stadium (4-2) | 5-7 | |
| » W: Jeff Mutis (1-1) L: Al Leiter (1-1) S: Derek Lilliquist (3) | Sixth | 4 out |
| Monday, April 19 |
| » Lost to Blue Jays (7-5), 7-1 | Cleveland Stadium (4-3) | 5-8 | |
| » W: Juan Guzman (1-0) L: Mike Bielecki (1-2) | Fifth | 5 out |
| Tuesday, April 20 |
| » Lost to Angels (7-4), 7-2 | Anaheim Stadium (0-1) | 5-9 | Lost 2 |
| » W: Scott Sanderson (2-0) L: Jose Mesa (0-1) | Sixth | 6 out |
| Wednesday, April 21 |
| » Lost to Angels (8-4), 7-6 | Anaheim Stadium (0-2) | 5-10 | Lost 3 |
| » W: John Farrell (1-2) L: Charles Nagy (1-3) S: Steve Frey (1) | Sixth | 6 out |
| Thursday, April 22 |
| » Lost to Angels (9-4), 8-0 | Anaheim Stadium (0-3) | 5-11 | Lost 4 |
| » W: Chuck Finley (2-0) L: Mark Clark (1-2) | Fifth | 6 out |
| Saturday, April 24 |
| » Defeated Athletics (5-9), 10-3 | Oakland-Alameda County Stadium (1-0) | 6-11 | |
| » W: Mike Bielecki (2-2) L: Shawn Hillegas (1-2) | Fifth | 5½ out |
| Sunday, April 25 |
| » Defeated Athletics (5-10), 6-0 | Oakland-Alameda County Stadium (2-0) | 7-11 | Won 2 |
| » W: Jose Mesa (1-1) L: Storm Davis (0-3) | Fifth | 5½ out |
| Monday, April 26 |
| » Lost to Mariners (9-10), 6-3 | Kingdome (0-1) | 7-12 | |
| » W: Randy Johnson (3-1) L: Tom Kramer (0-1) | Fifth | 6½ out |
| Tuesday, April 27 |
| » Lost to Mariners (10-10), 4-0 | Kingdome (0-2) | 7-13 | Lost 2 |
| » W: Chris Bosio (2-1) L: Charles Nagy (1-4) | Sixth | 6½ out |
| Wednesday, April 28 |
| » Lost to Mariners (11-10), 4-0 | Kingdome (0-3) | 7-14 | Lost 3 |
| » W: Erik Hanson (3-0) L: Jeff Mutis (1-2) S: Norm Charlton (3) | Fifth | 6½ out |
| Friday, April 30 |
| » Lost to Athletics (7-11), 8-2 | Cleveland Stadium (4-4) | 7-15 | Lost 4 |
| » W: Rich Gossage (2-0) L: Eric Plunk (1-2) | Seventh | 8 out |
| Saturday, May 1 |
| » Defeated Athletics (7-12), 1-0 | Cleveland Stadium (5-4) | 8-15 | |
| » W: Jose Mesa (2-1) L: Storm Davis (0-4) S: Eric Plunk (1) | Seventh | 7 out |
| Sunday, May 2 |
| » Defeated Athletics (7-13), 10-2 | Cleveland Stadium (6-4) | 9-15 | Won 2 |
| » W: Charles Nagy (2-4) L: Bobby Witt (1-1) | Sixth | 6 out |
| Monday, May 3 |
| » Defeated Angels (13-9), 5-4 | Cleveland Stadium (7-4) | 10-15 | Won 3 |
| » W: Derek Lilliquist (1-0) L: Julio Valera (1-2) | Sixth | 5½ out |
| Tuesday, May 4 |
| » Defeated Angels (13-10), 5-3 | Cleveland Stadium (8-4) | 11-15 | Won 4 |
| » W: Dennis Cook (1-0) L: Scott Lewis (0-1) S: Derek Lilliquist (4) | Sixth | 5½ out |
| Wednesday, May 5 |
| » Defeated Mariners (13-14), 3-2 | Cleveland Stadium (9-4) | 12-15 | Won 5 |
| » W: Mike Bielecki (3-2) L: John Cummings (0-5) S: Derek Lilliquist (5) | Fifth | 4½ out |
| Thursday, May 6 |
| » Lost to Mariners (14-14), 9-5 | Cleveland Stadium (9-5) | 12-16 | |
| » W: Randy Johnson (4-2) L: Jose Mesa (2-2) | Sixth | 5 out |
| Friday, May 7 |
| » Lost to White Sox (16-11), 6-5 | Comiskey Park II (0-1) | 12-17 | Lost 2 |
| » W: Wilson Alvarez (3-0) L: Charles Nagy (2-5) S: Roberto Hernandez (5) | Sixth | 6 out |
| Former Indian Thurman Tucker dies in Oklahoma City, OK at the age of 76. |
| Saturday, May 8 |
| » Lost to White Sox (17-11), 10-7 | Comiskey Park II (0-2) | 12-18 | Lost 3 |
| » W: Jack McDowell (6-1) L: Cliff Young (0-1) S: Roberto Hernandez (6) | Sixth | 6 out |
| Sunday, May 9 |
| » Lost to White Sox (18-11), 6-5 | Comiskey Park II (0-3) | 12-19 | Lost 4 |
| » W: Scott Radinsky (2-0) L: Derek Lilliquist (1-1) | Seventh | 6 out |
| Tuesday, May 11 |
| » Lost to Royals (13-17), 7-6 | Cleveland Stadium (9-6) | 12-20 | Lost 5 |
| » W: Kevin Appier (3-3) L: Dennis Cook (1-1) S: Jeff Montgomery (8) | Seventh | 7½ out |
| » Major-league debuts: Jerry Dipoto (Indians) |
| Wednesday, May 12 |
| » Defeated Royals (13-18), 6-2 | Cleveland Stadium (10-6) | 13-20 | |
| » W: Jose Mesa (3-2) L: Mark Gardner (2-2) | Seventh | 7½ out |
| Thursday, May 13 |
| » Lost to Royals (14-18), 7-3 | Cleveland Stadium (10-7) | 13-21 | |
| » W: Hipolito Pichardo (3-1) L: Matt Young (0-1) | Sixth | 7½ out |
| Friday, May 14 |
| » Lost to Brewers (15-17), 5-2 | County Stadium (0-1) | 13-22 | Lost 2 |
| » W: Mike Boddicker (3-1) L: Cliff Young (0-2) S: Doug Henry (8) | Sixth | 8½ out |
| Saturday, May 15 |
| » Defeated Brewers (15-18), 9-5 | County Stadium (1-1) | 14-22 | |
| » W: Dennis Cook (2-1) L: Ricky Bones (1-2) | Sixth | 8½ out |
| Sunday, May 16 |
| » Lost to Brewers (16-18), 5-3 | County Stadium (1-2) | 14-23 | |
| » W: Jaime Navarro (1-3) L: Mike Bielecki (3-3) S: Doug Henry (9) | Sixth | 8½ out |
| Monday, May 17 |
| » Defeated Orioles (14-22), 2-0 | Oriole Park at Camden Yards (1-0) | 15-23 | |
| » W: Jose Mesa (4-2) L: Ben McDonald (2-5) S: Eric Plunk (2) | Fifth | 8 out |
| Tuesday, May 18 |
| » Lost to Orioles (15-22), 7-0 | Oriole Park at Camden Yards (1-1) | 15-24 | |
| » W: Fernando Valenzuela (1-3) L: Matt Young (0-2) | Sixth | 9 out |
| Wednesday, May 19 |
| » Lost to Orioles (16-22), 6-3 | Oriole Park at Camden Yards (1-2) | 15-25 | Lost 2 |
| » W: Rick Sutcliffe (4-2) L: Scott Scudder (0-1) S: Gregg Olson (8) | Seventh | 10 out |
| Former Indian Oscar Grimes dies in Westlake, OH at the age of 79. |
| Thursday, May 20 |
| » Defeated Orioles (16-23), 3-1 | Oriole Park at Camden Yards (2-2) | 16-25 | |
| » W: Dennis Cook (3-1) L: Jamie Moyer (0-1) S: Derek Lilliquist (6) | Sixth | 10 out |
| Former Indian Al Aber dies in Garfield Heights, OH at the age of 66. |
| Friday, May 21 |
| » Defeated Tigers (25-15), 10-5 | Cleveland Stadium (11-7) | 17-25 | Won 2 |
| » W: Mike Bielecki (4-3) L: Bill Gullickson (1-1) S: Cliff Young (1) | Fifth | 9 out |
| Saturday, May 22 |
| » Lost to Tigers (26-15), 5-1 | Cleveland Stadium (11-8) | 17-26 | |
| » W: Mike Moore (3-1) L: Jose Mesa (4-3) | Seventh | 10 out |
| » Major-league debuts: Bill Wertz (Indians) |
| Sunday, May 23 |
| » Lost to Tigers (27-15), 4-2 | Cleveland Stadium (11-9) | 17-27 | Lost 2 |
| » W: Mark Leiter (3-1) L: Matt Young (0-3) S: Mike Henneman (9) | Sixth | 11 out |
| Monday, May 24 |
| » Defeated Rangers (23-20), 4-1 | Cleveland Stadium (12-9) | 18-27 | |
| » W: Tom Kramer (1-1) L: Kevin Brown (4-3) | Sixth | 10 out |
| Tuesday, May 25 |
| » Lost to Rangers (24-20), 5-1 | Cleveland Stadium (12-10) | 18-28 | |
| » W: Charlie Leibrandt (5-2) L: Dennis Cook (3-2) | Seventh | 11 out |
| Wednesday, May 26 |
| » Defeated Rangers (24-21), 7-6 | Cleveland Stadium (13-10) | 19-28 | |
| » W: Jose Mesa (5-3) L: Kenny Rogers (3-4) S: Eric Plunk (3) | Seventh | 11 out |
| Friday, May 28 |
| » Lost to Twins (18-26), 7-6 | Hubert H. Humphrey Metrodome (0-1) | 19-29 | |
| » W: Rick Aguilera (1-0) L: Ted Power (0-2) | Sixth | 11 out |
| Saturday, May 29 |
| » Lost to Twins (19-26), 9-3 | Hubert H. Humphrey Metrodome (0-2) | 19-30 | Lost 2 |
| » W: Willie Banks (4-2) L: Mike Bielecki (4-4) | Sixth | 12 out |
| Sunday, May 30 |
| » Lost to Twins (20-26), 8-2 | Hubert H. Humphrey Metrodome (0-3) | 19-31 | Lost 3 |
| » W: Jim Deshaies (6-4) L: Tom Kramer (1-2) S: Mike Trombley (1) | Sixth | 12 out |
| Monday, May 31 |
| » Lost to Yankees (29-22), 8-2 | Yankee Stadium (0-1) | 19-32 | Lost 4 |
| » W: Melido Perez (3-4) L: Dennis Cook (3-3) | Sixth | 12½ out |
| Tuesday, June 1 |
| » Defeated Yankees (29-23), 15-6 | Yankee Stadium (1-1) | 20-32 | |
| » W: Cliff Young (1-2) L: Mike Witt (3-2) | Seventh | 11½ out |
| Wednesday, June 2 |
| » Lost to Yankees (30-23), 8-5 | Yankee Stadium (1-2) | 20-33 | |
| » W: Jimmy Key (6-2) L: Matt Young (0-4) S: Steve Farr (12) | Seventh | 11½ out |
| Friday, June 4 |
| » Lost to Twins (23-27), 3-2 | Cleveland Stadium (13-11) | 20-34 | Lost 2 |
| » W: Jim Deshaies (7-4) L: Jeremy Hernandez (0-3) S: Rick Aguilera (15) | Seventh | 12 out |
| Saturday, June 5 |
| » Defeated Twins (23-28), 7-6 | Cleveland Stadium (14-11) | 21-34 | |
| » W: Eric Plunk (2-2) L: Mike Trombley (2-3) | Seventh | 12 out |
| Sunday, June 6 |
| » Lost to Twins (24-28), 5-4 | Cleveland Stadium (14-12) | 21-35 | |
| » W: Scott Erickson (3-6) L: Dennis Cook (3-4) S: Rick Aguilera (16) | Seventh | 13 out |
| Tuesday, June 8 |
| » Defeated Red Sox (28-28), 5-4 | Cleveland Stadium (15-12) | 22-35 | |
| » W: Derek Lilliquist (2-1) L: Greg Harris (2-1) | Seventh | 12½ out |
| Wednesday, June 9 |
| » Defeated Red Sox (28-29), 3-2 | Cleveland Stadium (16-12) | 23-35 | Won 2 |
| » W: Cliff Young (2-2) L: Danny Darwin (5-5) S: Eric Plunk (4) | Seventh | 12½ out |
| Friday, June 11 |
| » Defeated Rangers (28-30), 8-3 | Arlington Stadium (1-0) | 24-35 | Won 3 |
| » W: Heathcliff Slocumb (2-0) L: Kevin Brown (5-4) | Seventh | 13 out |
| Saturday, June 12 |
| » Defeated Rangers (28-31), 10-9 | Arlington Stadium (2-0) | 25-35 | Won 4 |
| » W: Matt Young (1-4) L: Kenny Rogers (4-5) S: Derek Lilliquist (7) | Seventh | 13 out |
| Sunday, June 13 |
| » Lost to Rangers (29-31), 5-1 | Arlington Stadium (2-1) | 25-36 | |
| » W: Roger Pavlik (3-2) L: Jose Mesa (5-4) | Seventh | 13 out |
| Monday, June 14 |
| » Lost to Tigers (39-23), 7-3 | Tiger Stadium (0-1) | 25-37 | Lost 2 |
| » W: David Wells (8-1) L: Mike Bielecki (4-5) | Sixth | 14 out |
| Tuesday, June 15 |
| » Lost to Tigers (40-23), 10-4 | Tiger Stadium (0-2) | 25-38 | Lost 3 |
| » W: Bill Krueger (5-2) L: Paul Abbott (0-1) | Sixth | 15 out |
| Wednesday, June 16 |
| » Defeated Tigers (40-24), 8-2 | Tiger Stadium (1-2) | 26-38 | |
| » W: Tom Kramer (2-2) L: Bill Gullickson (4-3) S: Jeremy Hernandez (1) | Seventh | 14 out |
| Thursday, June 17 |
| » Lost to Tigers (41-24), 9-5 | Tiger Stadium (1-3) | 26-39 | |
| » W: Mike Moore (5-3) L: Heathcliff Slocumb (2-1) | Seventh | 15 out |
| Friday, June 18 |
| » Lost to Orioles (34-32), 4-1 | Cleveland Stadium (16-13) | 26-40 | Lost 2 |
| » W: Ben McDonald (3-6) L: Jose Mesa (5-5) S: Gregg Olson (18) | Seventh | 15 out |
| Saturday, June 19 |
| » Defeated Orioles (34-33), 3-0 | Cleveland Stadium (17-13) | 27-40 | |
| » W: Mark Clark (2-2) L: Fernando Valenzuela (2-7) S: Eric Plunk (5) | Seventh | 15 out |
| Sunday, June 20 |
| » Lost to Orioles (35-33), 6-3 | Cleveland Stadium (17-14) | 27-41 | |
| » W: Jamie Moyer (3-3) L: Matt Young (1-5) S: Gregg Olson (19) | Seventh | 16 out |
| Monday, June 21 |
| » Defeated Brewers (29-38), 3-0 | Cleveland Stadium (18-14) | 28-41 | |
| » W: Tom Kramer (3-2) L: Jaime Navarro (5-4) S: Jeremy Hernandez (2) | Seventh | 15½ out |
| Tuesday, June 22 |
| » Defeated Brewers (29-39), 3-2 | Cleveland Stadium (19-14) | 29-41 | Won 2 |
| » W: Heathcliff Slocumb (3-1) L: Cal Eldred (9-7) S: Derek Lilliquist (8) | Seventh | 14½ out |
| Former Indian Bubba Phillips dies in Hattiesburg, MS at the age of 66. |
| Wednesday, June 23 |
| » Defeated Brewers (29-40), 3-1 | Cleveland Stadium (20-14) | 30-41 | Won 3 |
| » W: Jose Mesa (6-5) L: Bill Wegman (4-12) S: Jeremy Hernandez (3) | Sixth | 13½ out |
| Thursday, June 24 |
| » Lost to Brewers (30-40), 5-3 | Cleveland Stadium (20-15) | 30-42 | |
| » W: Ricky Bones (4-5) L: Mark Clark (2-3) S: Doug Henry (13) | Seventh | 13½ out |
| Friday, June 25 |
| » Defeated Royals (37-34), 6-1 | Cleveland Stadium (21-15) | 31-42 | |
| » W: Dennis Cook (4-4) L: Mark Gubicza (0-6) | Seventh | 12½ out |
| Saturday, June 26 |
| » Defeated Royals (37-35), 7-4 | Cleveland Stadium (22-15) | 32-42 | Won 2 |
| » W: Jeremy Hernandez (1-3) L: Frank DiPino (1-1) S: Eric Plunk (6) | Sixth | 12½ out |
| Sunday, June 27 |
| » Defeated Royals (37-36), 3-2 | Cleveland Stadium (23-15) | 33-42 | Won 3 |
| » W: Eric Plunk (3-2) L: David Cone (5-8) | Sixth | 12½ out |
| Monday, June 28 |
| » Defeated White Sox (39-34), 2-0 | Cleveland Stadium (24-15) | 34-42 | Won 4 |
| » W: Jose Mesa (7-5) L: Jason Bere (3-2) S: Eric Plunk (7) | Sixth | 12½ out |
| Tuesday, June 29 |
| » Defeated White Sox (39-35), 8-2 | Cleveland Stadium (25-15) | 35-42 | Won 5 |
| » W: Mark Clark (3-3) L: Rodney Bolton (0-4) | Sixth | 12½ out |
| Wednesday, June 30 |
| » Defeated White Sox (39-36), 4-2 | Cleveland Stadium (26-15) | 36-42 | Won 6 |
| » W: Dennis Cook (5-4) L: Wilson Alvarez (7-4) S: Jeremy Hernandez (4) | Sixth | 11½ out |
| Friday, July 2 |
| » Defeated Angels (37-40), 10-8 | Anaheim Stadium (1-3) | 37-42 | Won 7 |
| » W: Heathcliff Slocumb (4-1) L: Gene Nelson (0-1) S: Eric Plunk (8) | Sixth | 10½ out |
| Saturday, July 3 |
| » Defeated Angels (37-41), 5-3 | Anaheim Stadium (2-3) | 38-42 | Won 8 |
| » W: Jose Mesa (8-5) L: Hilly Hathaway (1-1) S: Eric Plunk (9) | Sixth | 9½ out |
| Sunday, July 4 |
| » Lost to Angels (38-41), 7-6 | Anaheim Stadium (2-4) | 38-43 | |
| » W: Mike Butcher (1-0) L: Matt Young (1-6) | Sixth | 9½ out |
| Monday, July 5 |
| » Lost to Athletics (36-41), 6-5 | Oakland-Alameda County Stadium (2-1) | 38-44 | Lost 2 |
| » W: Vince Horsman (1-0) L: Dennis Cook (5-5) S: Dennis Eckersley (19) | Sixth | 9 out |
| » Defeated Athletics (36-42), 6-2 | Oakland-Alameda County Stadium (3-1) | 39-44 | |
| » W: Mark Clark (4-3) L: Curt Young (1-1) S: Jeremy Hernandez (5) | Sixth | 9 out |
| Tuesday, July 6 |
| » Defeated Athletics (36-43), 11-8 | Oakland-Alameda County Stadium (4-1) | 40-44 | Won 2 |
| » W: Eric Plunk (4-2) L: Rich Gossage (4-4) S: Jeremy Hernandez (6) | Sixth | 9 out |
| » Major-league debuts: Albie Lopez (Indians) |
| Wednesday, July 7 |
| » Lost to Athletics (37-43), 3-0 | Oakland-Alameda County Stadium (4-2) | 40-45 | |
| » W: Joe Boever (4-2) L: Jose Mesa (8-6) S: Dennis Eckersley (20) | Sixth | 9 out |
| Former Indian Ben Chapman dies in Hoover, AL at the age of 85. |
| Friday, July 9 |
| » Lost to Mariners (42-44), 6-4 | Kingdome (0-4) | 40-46 | Lost 2 |
| » W: Dave Fleming (4-1) L: Cliff Young (2-3) S: Chris Bosio (1) | Sixth | 8½ out |
| Saturday, July 10 |
| » Lost to Mariners (43-44), 7-6 | Kingdome (0-5) | 40-47 | Lost 3 |
| » W: Chris Bosio (3-4) L: Jeremy Hernandez (1-4) | Sixth | 8½ out |
| Sunday, July 11 |
| » Lost to Mariners (44-44), 5-4 | Kingdome (0-6) | 40-48 | Lost 4 |
| » W: Bob Ayrault (3-1) L: Eric Plunk (4-3) | Sixth | 8½ out |
| Thursday, July 15 |
| » Defeated Angels (43-44), 7-3 | Cleveland Stadium (27-15) | 41-48 | |
| » W: Jerry Dipoto (1-0) L: Scott Sanderson (7-9) | Fifth | 8½ out |
| Friday, July 16 |
| » Lost to Angels (44-44), 2-1 | Cleveland Stadium (27-16) | 41-49 | |
| » W: Chuck Finley (11-6) L: Mark Clark (4-4) S: Mike Butcher (1) | Sixth | 8½ out |
| Saturday, July 17 |
| » Defeated Angels (44-45), 3-0 | Cleveland Stadium (28-16) | 42-49 | |
| » W: Jeff Mutis (2-2) L: Russ Springer (1-4) | Fourth | 7½ out |
| Sunday, July 18 |
| » Defeated Angels (44-46), 2-1 | Cleveland Stadium (29-16) | 43-49 | Won 2 |
| » W: Albie Lopez (1-0) L: Mark Langston (9-4) S: Jerry Dipoto (1) | Fourth | 7½ out |
| Monday, July 19 |
| » Defeated Athletics (39-50), 4-2 | Cleveland Stadium (30-16) | 44-49 | Won 3 |
| » W: Cliff Young (3-3) L: Todd VanPoppel (0-2) S: Jeremy Hernandez (7) | Fifth | 7½ out |
| Tuesday, July 20 |
| » Defeated Athletics (39-51), 9-5 | Cleveland Stadium (31-16) | 45-49 | Won 4 |
| » W: Jose Mesa (9-6) L: Mike Mohler (1-2) | Fifth | 7 out |
| Wednesday, July 21 |
| » Lost to Athletics (40-51), 7-2 | Cleveland Stadium (31-17) | 45-50 | |
| » W: Bob Welch (7-6) L: Bill Wertz (0-1) | Sixth | 7½ out |
| Thursday, July 22 |
| » Lost to Mariners (48-48), 3-2 | Cleveland Stadium (31-18) | 45-51 | Lost 2 |
| » W: Chris Bosio (4-5) L: Jeff Mutis (2-3) S: Brad Holman (1) | Sixth | 8½ out |
| Friday, July 23 |
| » Defeated Mariners (48-49), 9-4 | Cleveland Stadium (32-18) | 46-51 | |
| » W: Albie Lopez (2-0) L: Randy Johnson (10-6) | Fifth | 7½ out |
| Saturday, July 24 |
| » Lost to Mariners (49-49), 6-5 | Cleveland Stadium (32-19) | 46-52 | |
| » W: Jeff Nelson (3-1) L: Jerry Dipoto (1-1) S: Brad Holman (2) | Fifth | 8½ out |
| Sunday, July 25 |
| » Defeated Mariners (49-50), 11-9 | Cleveland Stadium (33-19) | 47-52 | |
| » W: Jeremy Hernandez (2-4) L: Jeff Nelson (3-2) S: Derek Lilliquist (9) | Fifth | 8½ out |
| Monday, July 26 |
| » Lost to White Sox (53-45), 4-3 | Comiskey Park II (0-4) | 47-53 | |
| » W: Jeff Schwarz (2-1) L: Jerry Dipoto (1-2) S: Roberto Hernandez (20) | Sixth | 9 out |
| Tuesday, July 27 |
| » Lost to White Sox (54-45), 7-4 | Comiskey Park II (0-5) | 47-54 | Lost 2 |
| » W: Jack McDowell (16-6) L: Jeff Mutis (2-4) S: Roberto Hernandez (21) | Sixth | 10 out |
| Wednesday, July 28 |
| » Lost to White Sox (55-45), 9-4 | Comiskey Park II (0-6) | 47-55 | Lost 3 |
| » W: Jason Bere (5-3) L: Albie Lopez (2-1) | Sixth | 11 out |
| Friday, July 30 |
| » Lost to Royals (54-49), 3-0 | Royals Stadium (0-1) | 47-56 | Lost 4 |
| » W: David Cone (7-10) L: Jose Mesa (9-7) | Fifth | 11½ out |
| Saturday, July 31 |
| » Defeated Royals (54-50), 6-4 | Royals Stadium (1-1) | 48-56 | |
| » W: Tom Kramer (4-2) L: Chris Haney (7-3) S: Eric Plunk (10) | Fifth | 11½ out |
| Former Indian Sam Langford dies in Plainview, TX at the age of 95. |
| Sunday, August 1 |
| » Defeated Royals (54-51), 9-5 | Royals Stadium (2-1) | 49-56 | Won 2 |
| » W: Bill Wertz (1-1) L: Kevin Appier (11-6) S: Eric Plunk (11) | Sixth | 11½ out |
| Tuesday, August 3 |
| » Defeated Tigers (53-54), 9-4 | Cleveland Stadium (34-19) | 50-56 | Won 3 |
| » W: Albie Lopez (3-1) L: Sean Bergman (1-3) S: Jerry Dipoto (2) | Sixth | 12 out |
| Wednesday, August 4 |
| » Lost to Tigers (54-54), 8-3 | Cleveland Stadium (34-20) | 50-57 | |
| » W: Mike Moore (8-5) L: Jose Mesa (9-8) | Sixth | 12 out |
| Thursday, August 5 |
| » Defeated Tigers (54-55), 8-4 | Cleveland Stadium (35-20) | 51-57 | |
| » W: Tom Kramer (5-2) L: John Doherty (9-7) | Sixth | 11 out |
| Friday, August 6 |
| » Lost to Orioles (60-49), 8-1 | Oriole Park at Camden Yards (2-3) | 51-58 | |
| » W: Rick Sutcliffe (9-7) L: Jeff Mutis (2-5) | Sixth | 12 out |
| Former Indian Bob Miller dies in Rancho Bernardo, CA at the age of 55. |
| Saturday, August 7 |
| » Lost to Orioles (61-49), 8-6 | Oriole Park at Camden Yards (2-4) | 51-59 | Lost 2 |
| » W: Alan Mills (2-3) L: Julian Tavarez (0-1) S: Gregg Olson (29) | Sixth | 12 out |
| » Major-league debuts: Julian Tavarez (Indians) |
| Sunday, August 8 |
| » Lost to Orioles (62-49), 7-6 | Oriole Park at Camden Yards (2-5) | 51-60 | Lost 3 |
| » W: Todd Frohwirth (6-4) L: Eric Plunk (4-4) | Fifth | 12 out |
| Tuesday, August 10 |
| » Lost to Brewers (45-66), 5-4 | County Stadium (1-3) | 51-61 | Lost 4 |
| » W: Doug Henry (3-4) L: Eric Plunk (4-5) | Sixth | 13 out |
| Wednesday, August 11 |
| » Defeated Brewers (45-67), 7-5 | County Stadium (2-3) | 52-61 | |
| » W: Jerry Dipoto (2-2) L: Jesse Orosco (1-3) S: Derek Lilliquist (10) | Sixth | 13 out |
| Thursday, August 12 |
| » Defeated Brewers (45-68), 8-6 | County Stadium (3-3) | 53-61 | Won 2 |
| » W: Jerry Dipoto (3-2) L: Carlos Maldonado (1-2) S: Eric Plunk (12) | Sixth | 12 out |
| Friday, August 13 |
| » Defeated Rangers (59-56), 6-3 | Cleveland Stadium (36-20) | 54-61 | Won 3 |
| » W: Jeremy Hernandez (3-4) L: Craig Lefferts (3-8) | Fifth | 11 out |
| Saturday, August 14 |
| » Defeated Rangers (59-57), 8-5 | Cleveland Stadium (37-20) | 55-61 | Won 4 |
| » W: Julian Tavarez (1-1) L: Steve Dreyer (1-1) S: Eric Plunk (13) | Fifth | 11 out |
| Sunday, August 15 |
| » Lost to Rangers (60-57), 4-1 | Cleveland Stadium (37-21) | 55-62 | |
| » W: Nolan Ryan (5-3) L: Jose Mesa (9-9) S: Tom Henke (27) | Fifth | 12 out |
| Monday, August 16 |
| » Lost to Blue Jays (69-51), 4-1 | Cleveland Stadium (37-22) | 55-63 | Lost 2 |
| » W: Juan Guzman (9-3) L: Bob Ojeda (0-1) S: Duane Ward (32) | Sixth | 13 out |
| Tuesday, August 17 |
| » Lost to Blue Jays (70-51), 6-4 | Cleveland Stadium (37-23) | 55-64 | Lost 3 |
| » W: Jack Morris (7-11) L: Tom Kramer (5-3) S: Duane Ward (33) | Sixth | 14 out |
| Wednesday, August 18 |
| » Lost to Blue Jays (71-51), 7-6 | Cleveland Stadium (37-24) | 55-65 | Lost 4 |
| » W: Danny Cox (6-5) L: Derek Lilliquist (2-2) S: Duane Ward (34) | Sixth | 15 out |
| Thursday, August 19 |
| » Defeated Red Sox (65-55), 5-1 | Fenway Park (1-3) | 56-65 | |
| » W: Julian Tavarez (2-1) L: Paul Quantrill (5-7) | Sixth | 14½ out |
| Friday, August 20 |
| » Defeated Red Sox (65-56), 7-6 | Fenway Park (2-3) | 57-65 | Won 2 |
| » W: Jerry Dipoto (4-2) L: Jeff Russell (0-4) | Sixth | 13½ out |
| Saturday, August 21 |
| » Defeated Red Sox (65-57), 10-5 | Fenway Park (3-3) | 58-65 | Won 3 |
| » W: Bill Wertz (2-1) L: Greg Harris (6-4) | Fifth | 12½ out |
| Sunday, August 22 |
| » Defeated Red Sox (65-58), 3-2 | Fenway Park (4-3) | 59-65 | Won 4 |
| » W: Tom Kramer (6-3) L: Ken Ryan (4-1) S: Jerry Dipoto (3) | Sixth | 12½ out |
| Monday, August 23 |
| » Defeated Blue Jays (72-54), 9-8 | Skydome (2-2) | 60-65 | Won 5 |
| » W: Jeremy Hernandez (4-4) L: Mark Eichhorn (2-1) S: Jerry Dipoto (4) | Fifth | 11½ out |
| Tuesday, August 24 |
| » Lost to Blue Jays (73-54), 8-6 | Skydome (2-3) | 60-66 | |
| » W: Todd Stottlemyre (7-9) L: Julian Tavarez (2-2) S: Duane Ward (35) | Sixth | 12½ out |
| Wednesday, August 25 |
| » Lost to Blue Jays (74-54), 10-7 | Skydome (2-4) | 60-67 | Lost 2 |
| » W: Pat Hentgen (15-7) L: Jose Mesa (9-10) S: Duane Ward (36) | Sixth | 13½ out |
| Thursday, August 26 |
| » Lost to Yankees (74-55), 4-0 | Cleveland Stadium (37-25) | 60-68 | Lost 3 |
| » W: Sterling Hitchcock (1-0) L: Bill Wertz (2-2) S: Bob Wickman (4) | Fifth | 13½ out |
| Friday, August 27 |
| » Defeated Yankees (74-56), 9-2 | Cleveland Stadium (38-25) | 61-68 | |
| » W: Jason Grimsley (1-0) L: Melido Perez (6-13) | Fifth | 12½ out |
| Saturday, August 28 |
| » Defeated Yankees (74-57), 8-4 | Cleveland Stadium (39-25) | 62-68 | Won 2 |
| » W: Jeff Mutis (3-5) L: Jimmy Key (15-5) S: Jeremy Hernandez (8) | Fifth | 11½ out |
| Sunday, August 29 |
| » Lost to Yankees (75-57), 14-8 | Cleveland Stadium (39-26) | 62-69 | |
| » W: Rich Monteleone (7-4) L: Jason Grimsley (1-1) | Fifth | 12½ out |
| Tuesday, August 31 |
| » Lost to Twins (56-75), 5-4 | Hubert H. Humphrey Metrodome (0-4) | 62-70 | Lost 2 |
| » W: Brett Merriman (1-0) L: Jason Grimsley (1-2) | Sixth | 14 out |
| Wednesday, September 1 |
| » Defeated Twins (56-76), 12-7 | Hubert H. Humphrey Metrodome (1-4) | 63-70 | |
| » W: Derek Lilliquist (3-2) L: Mike Trombley (5-4) S: Eric Plunk (14) | Sixth | 14 out |
| Thursday, September 2 |
| » Defeated Twins (56-77), 4-3 | Hubert H. Humphrey Metrodome (2-4) | 64-70 | Won 2 |
| » W: Tom Kramer (7-3) L: Kevin Tapani (7-14) S: Jerry Dipoto (5) | Sixth | 13½ out |
| » Major-league debuts: Manny Ramirez (Indians) |
| Friday, September 3 |
| » Defeated Yankees (76-60), 7-3 | Yankee Stadium (2-2) | 65-70 | Won 3 |
| » W: Bob Ojeda (1-1) L: Melido Perez (6-14) S: Jerry Dipoto (6) | Sixth | 12½ out |
| Saturday, September 4 |
| » Lost to Yankees (77-60), 4-0 | Yankee Stadium (2-3) | 65-71 | |
| » W: Jim Abbott (10-11) L: Bob Milacki (0-1) | Sixth | 12½ out |
| Sunday, September 5 |
| » Lost to Yankees (78-60), 7-2 | Yankee Stadium (2-4) | 65-72 | Lost 2 |
| » W: Bob Wickman (11-4) L: Jeff Mutis (3-6) | Fifth | 12½ out |
| Tuesday, September 7 |
| » Lost to Twins (59-78), 6-0 | Cleveland Stadium (39-27) | 65-73 | Lost 3 |
| » W: Kevin Tapani (8-14) L: Jason Grimsley (1-3) | Sixth | 12½ out |
| Wednesday, September 8 |
| » Defeated Twins (59-79), 15-8 | Cleveland Stadium (40-27) | 66-73 | |
| » W: Jose Mesa (10-10) L: Greg Brummett (3-4) | Sixth | 11½ out |
| Thursday, September 9 |
| » Lost to Twins (60-79), 5-3 | Cleveland Stadium (40-28) | 66-74 | |
| » W: Rick Aguilera (2-3) L: Derek Lilliquist (3-3) | Fifth | 11½ out |
| Friday, September 10 |
| » Defeated Red Sox (71-68), 7-4 | Cleveland Stadium (41-28) | 67-74 | |
| » W: Bob Ojeda (2-1) L: Roger Clemens (10-13) S: Jerry Dipoto (7) | Sixth | 12 out |
| » Lost to Red Sox (72-68), 5-4 | Cleveland Stadium (41-29) | 67-75 | |
| » W: Ken Ryan (5-2) L: Bill Wertz (2-3) | Sixth | 12 out |
| » Major-league debuts: Brian Anderson (Indians) |
| Saturday, September 11 |
| » Defeated Red Sox (72-69), 9-3 | Cleveland Stadium (42-29) | 68-75 | |
| » W: Derek Lilliquist (4-3) L: Paul Quantrill (5-10) | Sixth | 12 out |
| Sunday, September 12 |
| » Lost to Red Sox (73-69), 11-1 | Cleveland Stadium (42-30) | 68-76 | |
| » W: Nate Minchey (1-0) L: Jason Grimsley (1-4) | |