| Monday, April 5 |
| » Defeated Tigers (0-1), 9-4 | Oakland-Alameda County Stadium (1-0) | 1-0 | |
| » W: Bob Welch (1-0) L: Mike Moore (0-1) S: Dennis Eckersley (1) | First | -- |
| Wednesday, April 7 |
| » Defeated Tigers (0-2), 12-7 | Oakland-Alameda County Stadium (2-0) | 2-0 | Won 2 |
| » W: Kelly Downs (1-0) L: John Kiely (0-1) | First | -- |
| » Major-league debuts: Mike Mohler (Athletics) Greg Gohr (Tigers) |
| Thursday, April 8 |
| » Lost to Tigers (1-2), 3-2 | Oakland-Alameda County Stadium (2-1) | 2-1 | |
| » W: John Doherty (1-0) L: Storm Davis (0-1) S: Mike Henneman (1) | Second | ½ out |
| Friday, April 9 |
| » Lost to Brewers (2-1), 6-5 | Oakland-Alameda County Stadium (2-2) | 2-2 | Lost 2 |
| » W: Josias Manzanillo (1-0) L: Kelly Downs (1-1) S: Doug Henry (2) | Third | 1½ out |
| Saturday, April 10 |
| » Defeated Brewers (2-2), 4-3 | Oakland-Alameda County Stadium (3-2) | 3-2 | |
| » W: Bob Welch (2-0) L: Ricky Bones (0-1) S: Dennis Eckersley (2) | Second | ½ out |
| Sunday, April 11 |
| » Defeated Brewers (2-3), 8-2 | Oakland-Alameda County Stadium (4-2) | 4-2 | Won 2 |
| » W: Shawn Hillegas (1-0) L: Bill Wegman (0-2) | Second | ½ out |
| » Major-league debuts: Graeme Lloyd (Brewers) |
| Tuesday, April 13 |
| » Lost to Tigers (3-4), 20-4 | Tiger Stadium (0-1) | 4-3 | |
| » W: Mike Moore (1-1) L: Storm Davis (0-2) | Third | 2 out |
| Thursday, April 15 |
| » Lost to Tigers (4-4), 3-2 | Tiger Stadium (0-2) | 4-4 | Lost 2 |
| » W: Dave Haas (1-0) L: Dennis Eckersley (0-1) | Third | 2 out |
| Saturday, April 17 |
| » Lost to Brewers (3-5), 6-3 | County Stadium (0-1) | 4-5 | Lost 3 |
| » W: Bill Wegman (1-2) L: Bob Welch (2-1) | Fifth | 2½ out |
| Sunday, April 18 |
| » Lost to Brewers (4-5), 8-0 | County Stadium (0-2) | 4-6 | Lost 4 |
| » W: Cal Eldred (2-1) L: Shawn Hillegas (1-1) | Fifth | 3½ out |
| Tuesday, April 20 |
| » Defeated Yankees (6-7), 9-7 | Oakland-Alameda County Stadium (5-2) | 5-6 | |
| » W: Rich Gossage (1-0) L: John Habyan (0-1) | Fifth | 2½ out |
| Wednesday, April 21 |
| » Lost to Yankees (7-7), 5-3 | Oakland-Alameda County Stadium (5-3) | 5-7 | |
| » W: Rich Monteleone (2-1) L: Rick Honeycutt (0-1) S: Steve Farr (2) | Sixth | 3 out |
| Thursday, April 22 |
| » Lost to Yankees (8-7), 5-1 | Oakland-Alameda County Stadium (5-4) | 5-8 | Lost 2 |
| » W: Sam Militello (1-1) L: Ron Darling (0-1) S: Scott Kamieniecki (1) | Sixth | 4 out |
| Saturday, April 24 |
| » Lost to Indians (6-11), 10-3 | Oakland-Alameda County Stadium (5-5) | 5-9 | Lost 3 |
| » W: Mike Bielecki (2-2) L: Shawn Hillegas (1-2) | Fifth | 5½ out |
| Sunday, April 25 |
| » Lost to Indians (7-11), 6-0 | Oakland-Alameda County Stadium (5-6) | 5-10 | Lost 4 |
| » W: Jose Mesa (1-1) L: Storm Davis (0-3) | Sixth | 6½ out |
| Tuesday, April 27 |
| » Defeated Red Sox (11-9), 7-2 | Oakland-Alameda County Stadium (6-6) | 6-10 | |
| » W: Bobby Witt (1-0) L: Danny Darwin (0-4) S: Rich Gossage (1) | Seventh | 5½ out |
| Wednesday, April 28 |
| » Lost to Red Sox (12-9), 3-1 | Oakland-Alameda County Stadium (6-7) | 6-11 | |
| » W: Frank Viola (4-1) L: Bob Welch (2-2) S: Jeff Russell (4) | Seventh | 6½ out |
| Friday, April 30 |
| » Defeated Indians (7-15), 8-2 | Cleveland Stadium (1-0) | 7-11 | |
| » W: Rich Gossage (2-0) L: Eric Plunk (1-2) | Sixth | 5½ out |
| Saturday, May 1 |
| » Lost to Indians (8-15), 1-0 | Cleveland Stadium (1-1) | 7-12 | |
| » W: Jose Mesa (2-1) L: Storm Davis (0-4) S: Eric Plunk (1) | Seventh | 5½ out |
| Sunday, May 2 |
| » Lost to Indians (9-15), 10-2 | Cleveland Stadium (1-2) | 7-13 | Lost 2 |
| » W: Charles Nagy (2-4) L: Bobby Witt (1-1) | Seventh | 5½ out |
| Monday, May 3 |
| » Defeated Yankees (14-10), 4-2 | Yankee Stadium (1-0) | 8-13 | |
| » W: Bob Welch (3-2) L: Jim Abbott (1-5) S: Dennis Eckersley (3) | Seventh | 4½ out |
| Tuesday, May 4 |
| » Lost to Yankees (15-10), 4-2 | Yankee Stadium (1-1) | 8-14 | |
| » W: Bob Wickman (3-0) L: Shawn Hillegas (1-3) S: Steve Farr (6) | Sixth | 4½ out |
| Wednesday, May 5 |
| » Lost to Red Sox (16-11), 3-1 | Fenway Park (0-1) | 8-15 | Lost 2 |
| » W: Paul Quantrill (2-0) L: Edwin Nunez (0-1) S: Jeff Russell (7) | Sixth | 5½ out |
| » Major-league debuts: Brent Gates (Athletics) |
| Thursday, May 6 |
| » Defeated Red Sox (16-12), 6-3 | Fenway Park (1-1) | 9-15 | |
| » W: Bobby Witt (2-1) L: Roger Clemens (4-2) S: Dennis Eckersley (4) | Sixth | 5½ out |
| Friday, May 7 |
| » Lost to Angels (16-10), 4-3 | Anaheim Stadium (0-1) | 9-16 | |
| » W: Chuck Finley (3-2) L: Kelly Downs (1-2) S: Julio Valera (4) | Seventh | 6½ out |
| Saturday, May 8 |
| » Defeated Angels (16-11), 6-2 | Anaheim Stadium (1-1) | 10-16 | |
| » W: Bob Welch (4-2) L: Mark Langston (3-1) S: Dennis Eckersley (5) | Sixth | 6 out |
| Sunday, May 9 |
| » Lost to Angels (17-11), 7-6 | Anaheim Stadium (1-2) | 10-17 | |
| » W: Joe Grahe (2-1) L: Rick Honeycutt (0-2) | Sixth | 7 out |
| Monday, May 10 |
| » Lost to Rangers (17-12), 7-4 | Oakland-Alameda County Stadium (6-8) | 10-18 | Lost 2 |
| » W: Charlie Leibrandt (4-1) L: Ron Darling (0-2) S: Tom Henke (6) | Sixth | 8 out |
| Tuesday, May 11 |
| » Defeated Rangers (17-13), 6-0 | Oakland-Alameda County Stadium (7-8) | 11-18 | |
| » W: Bobby Witt (3-1) L: Kenny Rogers (3-2) | Seventh | 7 out |
| Wednesday, May 12 |
| » Defeated Rangers (17-14), 8-7 | Oakland-Alameda County Stadium (8-8) | 12-18 | Won 2 |
| » W: Dennis Eckersley (1-1) L: Tom Henke (1-1) | Seventh | 7 out |
| Thursday, May 13 |
| » Lost to Rangers (18-14), 9-5 | Oakland-Alameda County Stadium (8-9) | 12-19 | |
| » W: Matt Whiteside (1-0) L: Edwin Nunez (0-2) | Sixth | 7½ out |
| Friday, May 14 |
| » Defeated Mariners (17-18), 2-1 | Oakland-Alameda County Stadium (9-9) | 13-19 | |
| » W: Joe Boever (1-0) L: Rich DeLucia (1-2) | Sixth | 7½ out |
| Saturday, May 15 |
| » Defeated Mariners (17-19), 2-1 | Oakland-Alameda County Stadium (10-9) | 14-19 | Won 2 |
| » W: Rich Gossage (3-0) L: Jeff Nelson (0-1) | Seventh | 6½ out |
| Sunday, May 16 |
| » Lost to Mariners (18-19), 7-0 | Oakland-Alameda County Stadium (10-10) | 14-20 | |
| » W: Randy Johnson (6-2) L: Bobby Witt (3-2) | Sixth | 7½ out |
| Tuesday, May 18 |
| » Lost to Royals (17-19), 6-1 | Royals Stadium (0-1) | 14-21 | Lost 2 |
| » W: Mark Gardner (3-2) L: Bob Welch (4-3) | Seventh | 8 out |
| » Major-league debuts: Scott Lydy (Athletics) |
| Wednesday, May 19 |
| » Lost to Royals (18-19), 13-8 | Royals Stadium (0-2) | 14-22 | Lost 3 |
| » W: Tom Gordon (2-1) L: Shawn Hillegas (1-4) S: Jeff Montgomery (11) | Seventh | 8 out |
| Thursday, May 20 |
| » Defeated Royals (18-20), 4-1 | Royals Stadium (1-2) | 15-22 | |
| » W: Edwin Nunez (1-2) L: Mark Gubicza (0-5) S: Dennis Eckersley (6) | Seventh | 7½ out |
| Friday, May 21 |
| » Defeated White Sox (23-16), 12-11 | Comiskey Park II (1-0) | 16-22 | Won 2 |
| » W: Kelly Downs (2-2) L: Roberto Hernandez (0-1) S: Dennis Eckersley (7) | Sixth | 6½ out |
| Saturday, May 22 |
| » Defeated White Sox (23-17), 6-4 | Comiskey Park II (2-0) | 17-22 | Won 3 |
| » W: Bobby Witt (4-2) L: Dave Stieb (1-3) S: Dennis Eckersley (8) | Sixth | 5½ out |
| Sunday, May 23 |
| » Lost to White Sox (24-17), 5-4 | Comiskey Park II (2-1) | 17-23 | |
| » W: Roberto Hernandez (1-1) L: Rich Gossage (3-1) | Sixth | 6½ out |
| Tuesday, May 25 |
| » Defeated Twins (16-26), 3-1 | Oakland-Alameda County Stadium (11-10) | 18-23 | |
| » W: Storm Davis (1-4) L: Jim Deshaies (5-4) S: Dennis Eckersley (9) | Sixth | 5½ out |
| » Major-league debuts: Marcos Armas (Athletics) |
| Wednesday, May 26 |
| » Lost to Twins (17-26), 12-11 | Oakland-Alameda County Stadium (11-11) | 18-24 | |
| » W: George Tsamis (1-0) L: Joe Boever (1-1) | Sixth | 5½ out |
| Thursday, May 27 |
| » Major-league debuts: Jason Bere (White Sox) |
| Friday, May 28 |
| » Defeated Blue Jays (26-22), 3-2 | Oakland-Alameda County Stadium (12-11) | 19-24 | |
| » W: Bobby Witt (5-2) L: Danny Cox (4-1) S: Rick Honeycutt (1) | Sixth | 5 out |
| Saturday, May 29 |
| » Lost to Blue Jays (27-22), 5-3 | Oakland-Alameda County Stadium (12-12) | 19-25 | |
| » W: Dave Stewart (2-1) L: Bob Welch (4-4) S: Duane Ward (14) | Fifth | 6 out |
| Sunday, May 30 |
| » Lost to Blue Jays (28-22), 13-11 | Oakland-Alameda County Stadium (12-13) | 19-26 | Lost 2 |
| » W: Danny Cox (5-1) L: Mike Mohler (0-1) S: Duane Ward (15) | Sixth | 7 out |
| Monday, May 31 |
| » Lost to Orioles (21-29), 3-1 | Oakland-Alameda County Stadium (12-14) | 19-27 | Lost 3 |
| » W: Mike Mussina (7-2) L: Ron Darling (0-3) | Seventh | 7 out |
| Tuesday, June 1 |
| » Defeated Orioles (21-30), 4-1 | Oakland-Alameda County Stadium (13-14) | 20-27 | |
| » W: Shawn Hillegas (2-4) L: Ben McDonald (2-6) S: Dennis Eckersley (10) | Seventh | 6 out |
| » Major-league debuts: Craig Paquette (Athletics) |
| Wednesday, June 2 |
| » Lost to Orioles (22-30), 5-2 | Oakland-Alameda County Stadium (13-15) | 20-28 | |
| » W: Fernando Valenzuela (2-5) L: Bobby Witt (5-3) S: Gregg Olson (11) | Sixth | 6 out |
| Friday, June 4 |
| » Lost to Blue Jays (32-22), 4-3 | Skydome (0-1) | 20-29 | Lost 2 |
| » W: Woody Williams (1-0) L: Rich Gossage (3-2) | Seventh | 7½ out |
| Saturday, June 5 |
| » Lost to Blue Jays (33-22), 9-5 | Skydome (0-2) | 20-30 | Lost 3 |
| » W: Juan Guzman (5-0) L: Shawn Hillegas (2-5) | Seventh | 7½ out |
| Sunday, June 6 |
| » Defeated Blue Jays (33-23), 10-3 | Skydome (1-2) | 21-30 | |
| » W: Ron Darling (1-3) L: Jack Morris (3-6) | Sixth | 7½ out |
| Monday, June 7 |
| » Lost to Orioles (26-30), 3-2 | Oriole Park at Camden Yards (0-1) | 21-31 | |
| » W: Todd Frohwirth (3-4) L: Rich Gossage (3-3) S: Gregg Olson (14) | Seventh | 8½ out |
| Tuesday, June 8 |
| » Lost to Orioles (27-30), 6-4 | Oriole Park at Camden Yards (0-2) | 21-32 | Lost 2 |
| » W: Alan Mills (1-3) L: Storm Davis (1-5) S: Gregg Olson (15) | Seventh | 8½ out |
| Wednesday, June 9 |
| » Lost to Orioles (28-30), 7-4 | Oriole Park at Camden Yards (0-3) | 21-33 | Lost 3 |
| » W: Rick Sutcliffe (6-2) L: Bob Welch (4-5) S: Brad Pennington (2) | Sixth | 9½ out |
| Friday, June 11 |
| » Lost to Twins (27-29), 11-8 | Hubert H. Humphrey Metrodome (0-1) | 21-34 | Lost 4 |
| » W: Mike Trombley (3-3) L: Edwin Nunez (1-3) S: Rick Aguilera (19) | Sixth | 9½ out |
| Saturday, June 12 |
| » Lost to Twins (28-29), 7-2 | Hubert H. Humphrey Metrodome (0-2) | 21-35 | Lost 5 |
| » W: Jim Deshaies (8-4) L: Bobby Witt (5-4) | Seventh | 9½ out |
| Sunday, June 13 |
| » Defeated Twins (28-30), 7-6 | Hubert H. Humphrey Metrodome (1-2) | 22-35 | |
| » W: Edwin Nunez (2-3) L: George Tsamis (1-1) S: Dennis Eckersley (11) | Seventh | 9½ out |
| » Major-league debuts: Eddie Guardado (Twins) |
| Monday, June 14 |
| » Defeated White Sox (31-29), 7-3 | Oakland-Alameda County Stadium (14-15) | 23-35 | Won 2 |
| » W: Curt Young (1-0) L: Kirk McCaskill (2-7) | Sixth | 8½ out |
| Tuesday, June 15 |
| » Lost to White Sox (32-29), 4-0 | Oakland-Alameda County Stadium (14-16) | 23-36 | |
| » W: Wilson Alvarez (6-2) L: Bob Welch (4-6) | Seventh | 8½ out |
| Wednesday, June 16 |
| » Lost to White Sox (33-29), 4-0 | Oakland-Alameda County Stadium (14-17) | 23-37 | Lost 2 |
| » W: Jack McDowell (10-4) L: Ron Darling (1-4) | Seventh | 9½ out |
| Thursday, June 17 |
| » Defeated White Sox (33-30), 5-2 | Oakland-Alameda County Stadium (15-17) | 24-37 | |
| » W: Bobby Witt (6-4) L: Alex Fernandez (7-4) S: Dennis Eckersley (12) | Seventh | 9 out |
| Friday, June 18 |
| » Defeated Royals (34-30), 10-9 | Oakland-Alameda County Stadium (16-17) | 25-37 | Won 2 |
| » W: Rich Gossage (4-3) L: Tom Gordon (4-2) S: Dennis Eckersley (13) | Sixth | 8 out |
| Saturday, June 19 |
| » Lost to Royals (35-30), 3-0 | Oakland-Alameda County Stadium (16-18) | 25-38 | |
| » W: Kevin Appier (8-4) L: Joe Boever (1-2) S: Jeff Montgomery (20) | Seventh | 9 out |
| Sunday, June 20 |
| » Defeated Royals (35-31), 4-1 | Oakland-Alameda County Stadium (17-18) | 26-38 | |
| » W: Bob Welch (5-6) L: Mark Gardner (4-4) S: Dennis Eckersley (14) | Sixth | 8 out |
| Monday, June 21 |
| » Defeated Mariners (34-35), 5-3 | Kingdome (1-0) | 27-38 | Won 2 |
| » W: Storm Davis (2-5) L: Rich DeLucia (2-4) S: Dennis Eckersley (15) | Fifth | 7 out |
| Tuesday, June 22 |
| » Defeated Mariners (34-36), 10-3 | Kingdome (2-0) | 28-38 | Won 3 |
| » W: Bobby Witt (7-4) L: Jim Converse (1-3) | Sixth | 7 out |
| Wednesday, June 23 |
| » Lost to Mariners (35-36), 8-7 | Kingdome (2-1) | 28-39 | |
| » W: Dwayne Henry (2-2) L: Shawn Hillegas (2-6) | Sixth | 8 out |
| Thursday, June 24 |
| » Defeated Mariners (35-37), 3-2 | Kingdome (3-1) | 29-39 | |
| » W: Dennis Eckersley (2-1) L: Randy Johnson (9-4) | Sixth | 7½ out |
| Saturday, June 26 |
| » Lost to Rangers (32-39), 10-7 | Arlington Stadium (0-1) | 29-40 | |
| » W: Matt Whiteside (2-1) L: Storm Davis (2-6) S: Tom Henke (13) | Sixth | 8 out |
| Sunday, June 27 |
| » Lost to Rangers (33-39), 4-0 | Arlington Stadium (0-2) | 29-41 | Lost 2 |
| » W: Kevin Brown (6-6) L: Bobby Witt (7-5) | Sixth | 9 out |
| Tuesday, June 29 |
| » Defeated Angels (37-37), 8-7 | Oakland-Alameda County Stadium (18-18) | 30-41 | |
| » W: Edwin Nunez (3-3) L: Ken Patterson (0-1) | Seventh | 7½ out |
| Wednesday, June 30 |
| » Defeated Angels (37-38), 5-4 | Oakland-Alameda County Stadium (19-18) | 31-41 | Won 2 |
| » W: Joe Boever (2-2) L: Russ Springer (0-3) S: Dennis Eckersley (16) | Seventh | 6½ out |
| Thursday, July 1 |
| » Defeated Angels (37-39), 6-3 | Oakland-Alameda County Stadium (20-18) | 32-41 | Won 3 |
| » W: Bob Welch (6-6) L: Chuck Finley (9-6) S: Edwin Nunez (1) | Sixth | 5½ out |
| Friday, July 2 |
| » Defeated Yankees (46-34), 4-3 | Oakland-Alameda County Stadium (21-18) | 33-41 | Won 4 |
| » W: Bobby Witt (8-5) L: Bob Wickman (8-2) | Sixth | 5½ out |
| Saturday, July 3 |
| » Defeated Yankees (46-35), 5-4 | Oakland-Alameda County Stadium (22-18) | 34-41 | Won 5 |
| » W: Joe Boever (3-2) L: Melido Perez (5-7) S: Dennis Eckersley (17) | Fourth | 4½ out |
| Sunday, July 4 |
| » Defeated Yankees (46-36), 7-6 | Oakland-Alameda County Stadium (23-18) | 35-41 | Won 6 |
| » W: Shawn Hillegas (3-6) L: Bobby Munoz (2-1) S: Dennis Eckersley (18) | Fourth | 4½ out |
| Monday, July 5 |
| » Defeated Indians (38-44), 6-5 | Oakland-Alameda County Stadium (24-18) | 36-41 | Won 7 |
| » W: Vince Horsman (1-0) L: Dennis Cook (5-5) S: Dennis Eckersley (19) | Fifth | 5 out |
| » Lost to Indians (39-44), 6-2 | Oakland-Alameda County Stadium (24-19) | 36-42 | |
| » W: Mark Clark (4-3) L: Curt Young (1-1) S: Jeremy Hernandez (5) | Fifth | 5 out |
| Tuesday, July 6 |
| » Lost to Indians (40-44), 11-8 | Oakland-Alameda County Stadium (24-20) | 36-43 | Lost 2 |
| » W: Eric Plunk (4-2) L: Rich Gossage (4-4) S: Jeremy Hernandez (6) | Fifth | 5 out |
| » Major-league debuts: Albie Lopez (Indians) |
| Wednesday, July 7 |
| » Defeated Indians (40-45), 3-0 | Oakland-Alameda County Stadium (25-20) | 37-43 | |
| » W: Joe Boever (4-2) L: Jose Mesa (8-6) S: Dennis Eckersley (20) | Fifth | 5 out |
| Thursday, July 8 |
| » Lost to Red Sox (43-41), 11-9 | Oakland-Alameda County Stadium (25-21) | 37-44 | |
| » W: John Dopson (7-5) L: Todd VanPoppel (0-1) S: Jeff Russell (19) | Fifth | 6 out |
| Friday, July 9 |
| » Defeated Red Sox (43-42), 4-2 | Oakland-Alameda County Stadium (26-21) | 38-44 | |
| » W: Ron Darling (2-4) L: Paul Quantrill (4-6) S: Dennis Eckersley (21) | Sixth | 5 out |
| Saturday, July 10 |
| » Lost to Red Sox (44-42), 5-0 | Oakland-Alameda County Stadium (26-22) | 38-45 | |
| » W: Aaron Sele (2-0) L: Kelly Downs (2-3) S: Greg Harris (3) | Fifth | 5 out |
| Sunday, July 11 |
| » Lost to Red Sox (45-42), 3-2 | Oakland-Alameda County Stadium (26-23) | 38-46 | Lost 2 |
| » W: Danny Darwin (8-7) L: Bobby Witt (8-6) S: Jeff Russell (20) | Fifth | 6 out |
| Thursday, July 15 |
| » Defeated Yankees (48-42), 8-3 | Yankee Stadium (2-1) | 39-46 | |
| » W: Mike Mohler (1-1) L: Melido Perez (5-9) | Sixth | 6 out |
| Friday, July 16 |
| » Lost to Yankees (49-42), 10-3 | Yankee Stadium (2-2) | 39-47 | |
| » W: Jimmy Key (12-2) L: Kelly Downs (2-4) | Sixth | 7 out |
| Saturday, July 17 |
| » Lost to Yankees (50-42), 9-5 | Yankee Stadium (2-3) | 39-48 | Lost 2 |
| » W: Jim Abbott (6-8) L: Bobby Witt (8-7) | Fifth | 8 out |
| Sunday, July 18 |
| » Lost to Yankees (51-42), 13-6 | Yankee Stadium (2-4) | 39-49 | Lost 3 |
| » W: Steve Howe (3-3) L: Edwin Nunez (3-4) | Fifth | 9 out |
| Monday, July 19 |
| » Lost to Indians (44-49), 4-2 | Cleveland Stadium (1-3) | 39-50 | Lost 4 |
| » W: Cliff Young (3-3) L: Todd VanPoppel (0-2) S: Jeremy Hernandez (7) | Sixth | 9 out |
| Tuesday, July 20 |
| » Lost to Indians (45-49), 9-5 | Cleveland Stadium (1-4) | 39-51 | Lost 5 |
| » W: Jose Mesa (9-6) L: Mike Mohler (1-2) | Sixth | 10 out |
| Wednesday, July 21 |
| » Defeated Indians (45-50), 7-2 | Cleveland Stadium (2-4) | 40-51 | |
| » W: Bob Welch (7-6) L: Bill Wertz (0-1) | Sixth | 9 out |
| Thursday, July 22 |
| » Lost to Red Sox (52-43), 9-7 | Fenway Park (1-2) | 40-52 | |
| » W: Ken Ryan (4-0) L: Edwin Nunez (3-5) S: Jeff Russell (25) | Seventh | 10 out |
| Friday, July 23 |
| » Lost to Red Sox (53-43), 6-5 | Fenway Park (1-3) | 40-53 | Lost 2 |
| » W: Greg Harris (5-3) L: Rich Gossage (4-5) | Seventh | 10 out |
| Saturday, July 24 |
| » Lost to Red Sox (54-43), 5-3 | Fenway Park (1-4) | 40-54 | Lost 3 |
| » W: Aaron Sele (4-0) L: Kelly Downs (2-5) S: Jeff Russell (26) | Seventh | 11 out |
| Sunday, July 25 |
| » Lost to Red Sox (55-43), 8-1 | Fenway Park (1-5) | 40-55 | Lost 4 |
| » W: Frank Viola (6-8) L: Bob Welch (7-7) S: Paul Quantrill (1) | Seventh | 11 out |
| Monday, July 26 |
| » Defeated Angels (44-54), 11-4 | Anaheim Stadium (2-2) | 41-55 | |
| » W: Ron Darling (3-4) L: Chuck Finley (11-8) | Seventh | 11 out |
| Tuesday, July 27 |
| » Lost to Angels (45-54), 15-8 | Anaheim Stadium (2-3) | 41-56 | |
| » W: Joe Grahe (3-1) L: Bobby Witt (8-8) S: Ken Patterson (1) | Seventh | 12 out |
| » Major-league debuts: Eduardo Perez (Angels) |
| Wednesday, July 28 |
| » Lost to Angels (46-54), 3-2 | Anaheim Stadium (2-4) | 41-57 | Lost 2 |
| » W: Mark Langston (10-5) L: Todd VanPoppel (0-3) S: Mike Butcher (2) | Seventh | 13 out |
| » Major-league debuts: Ty Van Burkleo (Angels) |
| Thursday, July 29 |
| » Defeated Angels (46-55), 2-1 | Anaheim Stadium (3-4) | 42-57 | |
| » W: Bob Welch (8-7) L: Phil Leftwich (0-1) S: Dennis Eckersley (22) | Seventh | 12½ out |
| » Major-league debuts: Phil Leftwich (Angels) |
| Friday, July 30 |
| » Defeated Rangers (51-51), 4-1 | Oakland-Alameda County Stadium (27-23) | 43-57 | Won 2 |
| » W: Ron Darling (4-4) L: Nolan Ryan (2-3) S: Dennis Eckersley (23) | Sixth | 12½ out |
| Saturday, July 31 |
| » Lost to Rangers (52-51), 8-2 | Oakland-Alameda County Stadium (27-24) | 43-58 | |
| » W: Kevin Brown (8-7) L: Bobby Witt (8-9) | Sixth | 13½ out |
| Sunday, August 1 |
| » Defeated Rangers (52-52), 9-5 | Oakland-Alameda County Stadium (28-24) | 44-58 | |
| » W: Todd VanPoppel (1-3) L: Kenny Rogers (8-7) | Sixth | 13½ out |
| Tuesday, August 3 |
| » Lost to Mariners (52-54), 5-4 | Oakland-Alameda County Stadium (28-25) | 44-59 | |
| » W: Randy Johnson (11-7) L: Edwin Nunez (3-6) S: Ted Power (2) | Seventh | 14 out |
| Wednesday, August 4 |
| » Defeated Mariners (52-55), 5-4 | Oakland-Alameda County Stadium (29-25) | 45-59 | |
| » W: Kelly Downs (3-5) L: Jeff Nelson (3-3) | Sixth | 13 out |
| Thursday, August 5 |
| » Lost to Mariners (53-55), 3-2 | Oakland-Alameda County Stadium (29-26) | 45-60 | |
| » W: Dave Fleming (7-1) L: Bobby Witt (8-10) S: Norm Charlton (18) | Fifth | 13 out |
| Friday, August 6 |
| » Defeated Royals (55-54), 5-2 | Royals Stadium (2-2) | 46-60 | |
| » W: Todd VanPoppel (2-3) L: Chris Haney (7-4) S: Dennis Eckersley (24) | Sixth | 12 out |
| Saturday, August 7 |
| » Lost to Royals (56-54), 5-2 | Royals Stadium (2-3) | 46-61 | |
| » W: Kevin Appier (12-6) L: Kelly Downs (3-6) S: Jeff Montgomery (33) | Sixth | 13 out |
| Sunday, August 8 |
| » Lost to Royals (57-54), 4-3 | Royals Stadium (2-4) | 46-62 | Lost 2 |
| » W: Hipolito Pichardo (6-7) L: Ron Darling (4-5) S: Jeff Montgomery (34) | Sixth | 13 out |
| Monday, August 9 |
| » Lost to White Sox (61-50), 5-4 | Comiskey Park II (2-2) | 46-63 | Lost 3 |
| » W: Alex Fernandez (13-6) L: Bobby Witt (8-11) S: Roberto Hernandez (24) | Seventh | 14 out |
| Tuesday, August 10 |
| » Lost to White Sox (62-50), 4-0 | Comiskey Park II (2-3) | 46-64 | Lost 4 |
| » W: Tim Belcher (10-7) L: Mike Mohler (1-3) | Seventh | 15 out |
| Wednesday, August 11 |
| » Defeated White Sox (62-51), 3-1 | Comiskey Park II (3-3) | 47-64 | |
| » W: Todd VanPoppel (3-3) L: Wilson Alvarez (8-8) S: Dennis Eckersley (25) | Seventh | 14 out |
| Friday, August 13 |
| » Lost to Twins (49-63), 5-2 | Oakland-Alameda County Stadium (29-27) | 47-65 | |
| » W: Eddie Guardado (3-4) L: Ron Darling (4-6) S: Rick Aguilera (28) | Seventh | 14½ out |
| Saturday, August 14 |
| » Lost to Twins (50-63), 5-1 | Oakland-Alameda County Stadium (29-28) | 47-66 | Lost 2 |
| » W: Larry Casian (3-1) L: Rick Honeycutt (0-3) | Seventh | 16 out |
| » Lost to Twins (51-63), 6-2 | Oakland-Alameda County Stadium (29-29) | 47-67 | Lost 3 |
| » W: Mike Trombley (5-3) L: Kelly Downs (3-7) S: George Tsamis (1) | Seventh | 16 out |
| Sunday, August 15 |
| » Lost to Twins (52-63), 12-5 | Oakland-Alameda County Stadium (29-30) | 47-68 | Lost 4 |
| » W: Scott Erickson (7-14) L: Mike Mohler (1-4) | Seventh | 16 out |
| Monday, August 16 |
| » Defeated Brewers (48-70), 4-1 | Oakland-Alameda County Stadium (30-30) | 48-68 | |
| » W: Todd VanPoppel (4-3) L: Rafael Novoa (0-2) S: Dennis Eckersley (26) | Seventh | 15½ out |
| Tuesday, August 17 |
| » Defeated Brewers (48-71), 6-3 | Oakland-Alameda County Stadium (31-30) | 49-68 | Won 2 |
| » W: Steve Karsay (1-0) L: Jaime Navarro (7-9) S: Dennis Eckersley (27) | Seventh | 15½ out |
| » Major-league debuts: Steve Karsay (Athletics) |
| Wednesday, August 18 |
| » Defeated Brewers (48-72), 2-1 | Oakland-Alameda County Stadium (32-30) | 50-68 | Won 3 |
| » W: Ron Darling (5-6) L: Angel Miranda (2-3) S: Dennis Eckersley (28) | Seventh | 14½ out |
| Friday, August 20 |
| » Defeated Tigers (63-61), 7-6 | Tiger Stadium (1-2) | 51-68 | Won 4 |
| » W: Bobby Witt (9-11) L: John Doherty (10-9) S: Dennis Eckersley (29) | Seventh | 14½ out |
| Saturday, August 21 |
| » Lost to Tigers (64-61), 4-3 | Tiger Stadium (1-3) | 51-69 | |
| » W: Bill Gullickson (10-6) L: Kelly Downs (3-8) S: Storm Davis (1) | Seventh | 15½ out |
| Sunday, August 22 |
| » Lost to Tigers (65-61), 5-3 | Tiger Stadium (1-4) | 51-70 | Lost 2 |
| » W: Tom Bolton (4-5) L: Todd VanPoppel (4-4) S: Mike Henneman (20) | Seventh | 16½ out |
| Monday, August 23 |
| » Lost to Tigers (66-61), 9-0 | Tiger Stadium (1-5) | 51-71 | Lost 3 |
| » W: Mike Moore (10-6) L: Steve Karsay (1-1) | Seventh | 16½ out |
| Tuesday, August 24 |
| » Lost to Brewers (51-74), 9-2 | County Stadium (0-3) | 51-72 | Lost 4 |
| » W: Ricky Bones (9-8) L: Rick Honeycutt (0-4) | Seventh | 18 out |
| » Lost to Brewers (52-74), 7-6 | County Stadium (0-4) | 51-73 | Lost 5 |
| » W: Matt Maysey (1-1) L: Kelly Downs (3-9) | Seventh | 18 out |
| Wednesday, August 25 |
| » Lost to Brewers (53-74), 12-2 | County Stadium (0-5) | 51-74 | Lost 6 |
| » W: Cal Eldred (14-12) L: Bobby Witt (9-12) | Seventh | 18 out |
| Thursday, August 26 |
| » Lost to Brewers (54-74), 5-3 | County Stadium (0-6) | 51-75 | Lost 7 |
| » W: Angel Miranda (3-3) L: Mike Mohler (1-5) S: Jesse Orosco (4) | Seventh | 18½ out |
| Friday, August 27 |
| » Lost to Tigers (69-61), 13-4 | Oakland-Alameda County Stadium (32-31) | 51-76 | Lost 8 |
| » W: Tom Bolton (5-5) L: Todd VanPoppel (4-5) | Seventh | 19 out |
| Saturday, August 28 |
| » Lost to Tigers (70-61), 5-3 | Oakland-Alameda County Stadium (32-32) | 51-77 | Lost 9 |
| » W: Mike Moore (11-6) L: Steve Karsay (1-2) S: Mike Henneman (21) | Seventh | 20 out |
| Sunday, August 29 |
| » Defeated Tigers (70-62), 7-3 | Oakland-Alameda County Stadium (33-32) | 52-77 | |
| » W: Bob Welch (9-7) L: John Doherty (11-10) | Seventh | 20 out |
| Monday, August 30 |
| » Lost to Blue Jays (76-57), 4-2 | Oakland-Alameda County Stadium (33-33) | 52-78 | |
| » W: Pat Hentgen (16-7) L: Ron Darling (5-7) S: Duane Ward (37) | Seventh | 21 out |
| Tuesday, August 31 |
| » Lost to Blue Jays (77-57), 3-2 | Oakland-Alameda County Stadium (33-34) | 52-79 | Lost 2 |
| » W: Danny Cox (7-6) L: Dennis Eckersley (2-2) S: Duane Ward (38) | Seventh | 22 out |
| Wednesday, September 1 |
| » Lost to Blue Jays (78-57), 8-3 | Oakland-Alameda County Stadium (33-35) | 52-80 | Lost 3 |
| » W: Juan Guzman (11-3) L: Mike Mohler (1-6) | Seventh | 23 out |
| » Major-league debuts: Roger Smithberg (Athletics) |
| Friday, September 3 |
| » Lost to Orioles (73-62), 5-4 | Oakland-Alameda County Stadium (33-36) | 52-81 | Lost 4 |
| » W: Alan Mills (4-3) L: Dennis Eckersley (2-3) | Seventh | 23½ out |
| Saturday, September 4 |
| » Lost to Orioles (74-62), 6-3 | Oakland-Alameda County Stadium (33-37) | 52-82 | Lost 5 |
| » W: Jamie Moyer (11-6) L: Steve Karsay (1-3) | Seventh | 24½ out |
| » Major-league debuts: Eric Helfand (Athletics) |
| Sunday, September 5 |
| » Lost to Orioles (75-62), 9-2 | Oakland-Alameda County Stadium (33-38) | 52-83 | Lost 6 |
| » W: Mike Mussina (14-5) L: Bob Welch (9-8) | Seventh | 25½ out |
| Tuesday, September 7 |
| » Defeated Blue Jays (78-61), 11-7 | Skydome (2-2) | 53-83 | |
| » W: Rick Honeycutt (1-4) L: Tony Castillo (3-1) | Seventh | 24 out |
| Wednesday, September 8 |
| » Defeated Blue Jays (78-62), 2-1 | Skydome (3-2) | 54-83 | Won 2 |
| » W: Bobby Witt (10-12) L: Duane Ward (2-3) S: Dennis Eckersley (30) | Seventh | 24 out |
| » Major-league debuts: Kurt Abbott (Athletics) |
| Thursday, September 9 |
| » Defeated Blue Jays (78-63), 7-4 | Skydome (4-2) | 55-83 | Won 3 |
| » W: Roger Smithberg (1-0) L: Tony Castillo (3-2) S: Dennis Eckersley (31) | Seventh | 23½ out |
| Friday, September 10 |
| » Defeated Orioles (77-64), 12-9 | Oriole Park at Camden Yards (1-3) | 56-83 | Won 4 |
| » W: Kelly Downs (4-9) L: Mark Williamson (7-4) S: Dennis Eckersley (32) | Seventh | 22½ out |
| Saturday, September 11 |
| » Lost to Orioles (78-64), 3-1 | Oriole Park at Camden Yards (1-4) | 56-84 | |
| » W: Ben McDonald (12-11) L: Bob Welch (9-9) | Seventh | 23½ out |
| Sunday, September 12 |
| » Lost to Orioles (79-64), 14-5 | Oriole Park at Camden Yards (1-5) | 56-85 | Lost 2 |
| » W: Jamie Moyer (12-6) L: Ron Darling (5-8) | Seventh | 23½ out |
| » Major-league debuts: Miguel Jimenez (Athletics) |
| Former Athletic Granny Hamner dies in Philadelphia, PA at the age of 67. |
| Monday, September 13 |
| » Defeated Twins (61-83), 7-2 | Hubert H. Humphrey Metrodome (2-2) | 57-85 | |
| » W: Bobby Witt (11-12) L: Scott Erickson (8-18) | Seventh | 22½ out |
| Tuesday, September 14 |
| » Defeated Twins (61-84), 8-3 | Hubert H. Humphrey Metrodome (3-2) | 58-85 | Won 2 |
| » W: Steve Karsay (2-3) L: Eddie Guardado (3-8) S: Roger Smithberg (1) | Seventh | 22½ out |
| Wednesday, September 15 |
| » Defeated Twins (61-85), 15-2 | Hubert H. Humphrey Metrodome (4-2) | 59-85 | Won 3 |
| » W: Todd VanPoppel (5-5) L: Willie Banks (9-11) | Seventh | 22½ out |
| Thursday, September 16 |
| » Lost to Twins (62-85), 5-4 | Hubert H. Humphrey Metrodome (4-3) | 59-86 | |
| » W: Mike Hartley (1-2) L: Roger Smithberg (1-1) | |