| Monday, April 6 |
| » Defeated Brewers (0-1), 4-2 | County Stadium (1-0) | 1-0 | |
| » W: Carl Willis (1-0) L: Edwin Nunez (0-1) S: Rick Aguilera (1) | First | -- |
| Wednesday, April 8 |
| » Lost to Brewers (1-1), 9-5 | County Stadium (1-1) | 1-1 | |
| » W: Bruce Ruffin (1-0) L: Rick Aguilera (0-1) | Third | 1½ out |
| » Major-league debuts: Pat Listach (Brewers) |
| Thursday, April 9 |
| » Defeated Brewers (1-2), 3-1 | County Stadium (2-1) | 2-1 | |
| » W: Bill Krueger (1-0) L: Jaime Navarro (0-1) S: Rick Aguilera (2) | Third | 1½ out |
| » Major-league debuts: William Suero (Brewers) |
| Friday, April 10 |
| » Defeated Rangers (4-1), 7-1 | Hubert H. Humphrey Metrodome (1-0) | 3-1 | Won 2 |
| » W: Kevin Tapani (1-0) L: Bobby Witt (0-1) | Third | 1 out |
| Saturday, April 11 |
| » Lost to Rangers (5-1), 10-8 | Hubert H. Humphrey Metrodome (1-1) | 3-2 | |
| » W: Jeff Russell (1-0) L: Rick Aguilera (0-2) S: Kenny Rogers (1) | Third | 2 out |
| Sunday, April 12 |
| » Lost to Rangers (6-1), 4-3 | Hubert H. Humphrey Metrodome (1-2) | 3-3 | Lost 2 |
| » W: Kevin Brown (2-0) L: Bob Kipper (0-1) | Fourth | 2½ out |
| » Major-league debuts: Pat Mahomes (Twins) |
| Tuesday, April 14 |
| » Lost to Brewers (3-4), 11-1 | Hubert H. Humphrey Metrodome (1-3) | 3-4 | Lost 3 |
| » W: Jaime Navarro (1-1) L: John Smiley (0-1) | Fifth | 2½ out |
| Wednesday, April 15 |
| » Lost to Brewers (4-4), 7-4 | Hubert H. Humphrey Metrodome (1-4) | 3-5 | Lost 4 |
| » W: Jim Austin (1-0) L: Carl Willis (1-1) | Fifth | 3½ out |
| Friday, April 17 |
| » Defeated White Sox (6-4), 7-0 | Comiskey Park II (1-0) | 4-5 | |
| » W: Bill Krueger (2-0) L: Charlie Hough (0-1) | Fifth | 3 out |
| Saturday, April 18 |
| » Lost to White Sox (7-4), 4-3 | Comiskey Park II (1-1) | 4-6 | |
| » W: Jack McDowell (3-0) L: Scott Erickson (0-1) | Sixth | 4 out |
| Sunday, April 19 |
| » Lost to White Sox (8-4), 4-1 | Comiskey Park II (1-2) | 4-7 | Lost 2 |
| » W: Greg Hibbard (3-0) L: John Smiley (0-2) S: Bobby Thigpen (4) | Sixth | 4 out |
| Monday, April 20 |
| » Lost to Mariners (7-7), 2-0 | Kingdome (0-1) | 4-8 | Lost 3 |
| » W: Randy Johnson (2-0) L: Kevin Tapani (1-1) | Sixth | 5 out |
| Tuesday, April 21 |
| » Defeated Mariners (7-8), 5-2 | Kingdome (1-1) | 5-8 | |
| » W: Pat Mahomes (1-0) L: Rich DeLucia (1-2) S: Rick Aguilera (3) | Sixth | 4 out |
| Wednesday, April 22 |
| » Defeated Mariners (7-9), 8-1 | Kingdome (2-1) | 6-8 | Won 2 |
| » W: Bill Krueger (3-0) L: Erik Hanson (1-3) | Sixth | 4 out |
| Thursday, April 23 |
| » Lost to Mariners (8-9), 3-2 | Kingdome (2-2) | 6-9 | |
| » W: Russ Swan (2-2) L: Scott Erickson (0-2) S: Mike Schooler (4) | Sixth | 4½ out |
| Friday, April 24 |
| » Defeated Athletics (11-6), 6-5 | Hubert H. Humphrey Metrodome (2-4) | 7-9 | |
| » W: Tom Edens (1-0) L: Rich Gossage (0-1) | Fifth | 3½ out |
| Saturday, April 25 |
| » Lost to Athletics (12-6), 8-4 | Hubert H. Humphrey Metrodome (2-5) | 7-10 | |
| » W: Joe Slusarski (2-0) L: Kevin Tapani (1-2) S: Dennis Eckersley (6) | Sixth | 4½ out |
| Sunday, April 26 |
| » Defeated Athletics (12-7), 8-4 | Hubert H. Humphrey Metrodome (3-5) | 8-10 | |
| » W: Pat Mahomes (2-0) L: Dave Stewart (1-2) S: Rick Aguilera (4) | Sixth | 3½ out |
| Monday, April 27 |
| » Defeated Orioles (11-8), 4-1 | Hubert H. Humphrey Metrodome (4-5) | 9-10 | Won 2 |
| » W: Bill Krueger (4-0) L: Rick Sutcliffe (3-2) S: Rick Aguilera (5) | Sixth | 3 out |
| Tuesday, April 28 |
| » Lost to Orioles (12-8), 10-5 | Hubert H. Humphrey Metrodome (4-6) | 9-11 | |
| » W: Mike Mussina (3-0) L: Scott Erickson (0-3) | Sixth | 4 out |
| Wednesday, April 29 |
| » Lost to Orioles (13-8), 5-4 | Hubert H. Humphrey Metrodome (4-7) | 9-12 | Lost 2 |
| » W: Storm Davis (1-1) L: Gary Wayne (0-1) S: Gregg Olson (3) | Sixth | 4 out |
| Friday, May 1 |
| » Lost to Yankees (14-8), 5-3 | Yankee Stadium (0-1) | 9-13 | Lost 3 |
| » W: Melido Perez (2-2) L: Kevin Tapani (1-3) S: Steve Farr (5) | Sixth | 5½ out |
| Saturday, May 2 |
| » Defeated Yankees (14-9), 7-6 | Yankee Stadium (1-1) | 10-13 | |
| » W: Bob Kipper (1-1) L: Lee Guetterman (0-1) S: Rick Aguilera (6) | Fifth | 4½ out |
| Sunday, May 3 |
| » Defeated Yankees (14-10), 4-2 | Yankee Stadium (2-1) | 11-13 | Won 2 |
| » W: Scott Erickson (1-3) L: Scott Kamieniecki (0-1) S: Rick Aguilera (7) | Fifth | 3½ out |
| Monday, May 4 |
| » Defeated Red Sox (11-11), 6-1 | Fenway Park (1-0) | 12-13 | Won 3 |
| » W: John Smiley (1-2) L: Roger Clemens (3-3) | Fifth | 2½ out |
| Tuesday, May 5 |
| » Lost to Red Sox (12-11), 4-1 | Fenway Park (1-1) | 12-14 | |
| » W: Frank Viola (3-2) L: Pat Mahomes (2-1) S: Jeff Reardon (6) | Fifth | 3 out |
| Wednesday, May 6 |
| » Lost to Orioles (18-9), 6-2 | Oriole Park at Camden Yards (0-1) | 12-15 | Lost 2 |
| » W: Ben McDonald (4-0) L: Kevin Tapani (1-4) | Fifth | 4 out |
| Thursday, May 7 |
| » Lost to Orioles (19-9), 5-4 | Oriole Park at Camden Yards (0-2) | 12-16 | Lost 3 |
| » W: Storm Davis (2-2) L: Rick Aguilera (0-3) | Fifth | 5 out |
| Friday, May 8 |
| » Defeated Indians (12-19), 7-4 | Hubert H. Humphrey Metrodome (5-7) | 13-16 | |
| » W: Scott Erickson (2-3) L: Charles Nagy (3-2) S: Rick Aguilera (8) | Fifth | 5 out |
| Saturday, May 9 |
| » Defeated Indians (12-20), 10-5 | Hubert H. Humphrey Metrodome (6-7) | 14-16 | Won 2 |
| » W: John Smiley (2-2) L: Dave Otto (2-3) | Fifth | 4½ out |
| Sunday, May 10 |
| » Defeated Indians (12-21), 10-6 | Hubert H. Humphrey Metrodome (7-7) | 15-16 | Won 3 |
| » W: Mark Guthrie (1-0) L: Jack Armstrong (1-4) S: Rick Aguilera (9) | Fifth | 4½ out |
| Tuesday, May 12 |
| » Defeated Red Sox (14-15), 6-3 | Hubert H. Humphrey Metrodome (8-7) | 16-16 | Won 4 |
| » W: Kevin Tapani (2-4) L: Mike Gardiner (2-1) S: Rick Aguilera (10) | Fifth | 3½ out |
| » Major-league debuts: Jeff Reboulet (Twins) |
| Wednesday, May 13 |
| » Defeated Red Sox (14-16), 4-3 | Hubert H. Humphrey Metrodome (9-7) | 17-16 | Won 5 |
| » W: Tom Edens (2-0) L: Greg Harris (2-3) | Fourth | 3 out |
| Friday, May 15 |
| » Lost to Indians (13-23), 5-0 | Cleveland Stadium (0-1) | 17-17 | |
| » W: Charles Nagy (4-2) L: Scott Erickson (2-4) | Fourth | 3 out |
| Saturday, May 16 |
| » Defeated Indians (13-24), 8-6 | Cleveland Stadium (1-1) | 18-17 | |
| » W: John Smiley (3-2) L: Jack Armstrong (1-5) S: Rick Aguilera (11) | Third | 2½ out |
| Sunday, May 17 |
| » Defeated Indians (13-25), 9-5 | Cleveland Stadium (2-1) | 19-17 | Won 2 |
| » W: Kevin Tapani (3-4) L: Dennis Cook (1-4) S: Rick Aguilera (12) | Third | 2 out |
| Monday, May 18 |
| » Defeated Blue Jays (25-15), 6-2 | Skydome (1-0) | 20-17 | Won 3 |
| » W: Gary Wayne (1-1) L: Duane Ward (1-2) | Third | 1½ out |
| Tuesday, May 19 |
| » Defeated Blue Jays (25-16), 7-1 | Skydome (2-0) | 21-17 | Won 4 |
| » W: Pat Mahomes (3-1) L: Dave Stieb (2-4) S: Tom Edens (1) | Third | 1½ out |
| Wednesday, May 20 |
| » Lost to Blue Jays (26-16), 8-7 | Skydome (2-1) | 21-18 | |
| » W: Tom Henke (2-1) L: Rick Aguilera (0-4) | Third | 2½ out |
| Friday, May 22 |
| » Lost to Tigers (19-22), 6-3 | Tiger Stadium (0-1) | 21-19 | Lost 2 |
| » W: Mark Leiter (3-1) L: John Smiley (3-3) S: Mike Henneman (8) | Third | 3½ out |
| Saturday, May 23 |
| » Defeated Tigers (19-23), 6-5 | Tiger Stadium (1-1) | 22-19 | |
| » W: Kevin Tapani (4-4) L: John Doherty (2-1) S: Rick Aguilera (13) | Third | 2½ out |
| Sunday, May 24 |
| » Defeated Tigers (19-24), 15-0 | Tiger Stadium (2-1) | 23-19 | Won 2 |
| » W: Bill Krueger (5-0) L: Frank Tanana (3-4) | Third | 2½ out |
| Tuesday, May 26 |
| » Lost to Yankees (25-19), 5-4 | Hubert H. Humphrey Metrodome (9-8) | 23-20 | |
| » W: Tim Leary (4-3) L: Pat Mahomes (3-2) S: Steve Howe (6) | Fourth | 2 out |
| Wednesday, May 27 |
| » Defeated Yankees (25-20), 5-1 | Hubert H. Humphrey Metrodome (10-8) | 24-20 | |
| » W: John Smiley (4-3) L: Melido Perez (4-4) | Fourth | 1 out |
| Friday, May 29 |
| » Defeated Tigers (21-26), 17-5 | Hubert H. Humphrey Metrodome (11-8) | 25-20 | Won 2 |
| » W: Kevin Tapani (5-4) L: Kevin Ritz (0-1) S: Carl Willis (1) | Third | 2½ out |
| Saturday, May 30 |
| » Defeated Tigers (21-27), 7-5 | Hubert H. Humphrey Metrodome (12-8) | 26-20 | Won 3 |
| » W: Tom Edens (3-0) L: Mike Henneman (0-2) S: Rick Aguilera (14) | Second | 2½ out |
| Sunday, May 31 |
| » Defeated Tigers (21-28), 4-1 | Hubert H. Humphrey Metrodome (13-8) | 27-20 | Won 4 |
| » W: Scott Erickson (3-4) L: Bill Gullickson (6-3) S: Mark Guthrie (1) | First | -- |
| Monday, June 1 |
| » Lost to Blue Jays (32-19), 5-3 | Hubert H. Humphrey Metrodome (13-9) | 27-21 | |
| » W: Duane Ward (3-2) L: Carl Willis (1-2) S: Tom Henke (9) | First | -- |
| Tuesday, June 2 |
| » Lost to Blue Jays (33-19), 7-5 | Hubert H. Humphrey Metrodome (13-10) | 27-22 | Lost 2 |
| » W: Pat Hentgen (4-0) L: Gary Wayne (1-2) S: Tom Henke (10) | Third | 1 out |
| Wednesday, June 3 |
| » Defeated Blue Jays (33-20), 11-3 | Hubert H. Humphrey Metrodome (14-10) | 28-22 | |
| » W: Kevin Tapani (6-4) L: Juan Guzman (6-1) | Third | 1 out |
| » Major-league debuts: J.T. Bruett (Twins) |
| Thursday, June 4 |
| » Defeated Rangers (31-25), 15-12 | Arlington Stadium (1-0) | 29-22 | Won 2 |
| » W: Bob Kipper (2-1) L: Edwin Nunez (1-2) S: Rick Aguilera (15) | Second | ½ out |
| Friday, June 5 |
| » Lost to Rangers (32-25), 5-4 | Arlington Stadium (1-1) | 29-23 | |
| » W: Jose Guzman (5-3) L: Willie Banks (0-1) S: Jeff Russell (14) | Third | 1½ out |
| Saturday, June 6 |
| » Defeated Rangers (32-26), 6-1 | Arlington Stadium (2-1) | 30-23 | |
| » W: John Smiley (5-3) L: Nolan Ryan (0-2) | Second | 1½ out |
| » Major-league debuts: Danilo Leon (Rangers) |
| Sunday, June 7 |
| » Lost to Rangers (33-26), 5-4 | Arlington Stadium (2-2) | 30-24 | |
| » W: Bobby Witt (7-4) L: Mark Guthrie (1-1) S: Jeff Russell (15) | Third | 1½ out |
| Monday, June 8 |
| » Lost to Royals (23-32), 9-6 | Royals Stadium (0-1) | 30-25 | Lost 2 |
| » W: Tom Gordon (1-6) L: Bob Kipper (2-2) S: Jeff Montgomery (13) | Third | 1½ out |
| Tuesday, June 9 |
| » Defeated Royals (23-33), 4-2 | Royals Stadium (1-1) | 31-25 | |
| » W: Bill Krueger (6-0) L: Mike Magnante (2-5) S: Rick Aguilera (16) | Third | 1½ out |
| Wednesday, June 10 |
| » Lost to Royals (24-33), 7-6 | Royals Stadium (1-2) | 31-26 | |
| » W: Rusty Meacham (4-0) L: Mark Guthrie (1-2) S: Jeff Montgomery (14) | Third | 2½ out |
| Friday, June 12 |
| » Defeated White Sox (28-29), 5-1 | Hubert H. Humphrey Metrodome (15-10) | 32-26 | |
| » W: John Smiley (6-3) L: Charlie Hough (2-3) S: Rick Aguilera (17) | Third | 2½ out |
| Saturday, June 13 |
| » Lost to White Sox (29-29), 4-2 | Hubert H. Humphrey Metrodome (15-11) | 32-27 | |
| » W: Jack McDowell (9-3) L: Scott Erickson (3-5) S: Bobby Thigpen (14) | Third | 3½ out |
| » Major-league debuts: Shawn Jeter (White Sox) |
| Sunday, June 14 |
| » Defeated White Sox (29-30), 8-7 | Hubert H. Humphrey Metrodome (16-11) | 33-27 | |
| » W: Tom Edens (4-0) L: Scott Radinsky (2-3) | Second | 3½ out |
| Monday, June 15 |
| » Lost to Royals (25-36), 7-0 | Hubert H. Humphrey Metrodome (16-12) | 33-28 | |
| » W: Mike Magnante (3-5) L: Bill Krueger (6-1) | Third | 4½ out |
| Tuesday, June 16 |
| » Lost to Royals (26-36), 7-5 | Hubert H. Humphrey Metrodome (16-13) | 33-29 | Lost 2 |
| » W: Kevin Appier (6-3) L: Bob Kipper (2-3) S: Jeff Montgomery (15) | Third | 4½ out |
| Wednesday, June 17 |
| » Defeated Royals (26-37), 4-2 | Hubert H. Humphrey Metrodome (17-13) | 34-29 | |
| » W: Rick Aguilera (1-4) L: Tom Gordon (1-7) | Second | 3½ out |
| Thursday, June 18 |
| » Defeated Royals (26-38), 3-1 | Hubert H. Humphrey Metrodome (18-13) | 35-29 | Won 2 |
| » W: Scott Erickson (4-5) L: Rick Reed (1-2) S: Rick Aguilera (18) | Second | 3 out |
| Friday, June 19 |
| » Lost to Mariners (29-37), 1-0 | Hubert H. Humphrey Metrodome (18-14) | 35-30 | |
| » W: Dave Fleming (10-2) L: Kevin Tapani (6-5) | Second | 4 out |
| Saturday, June 20 |
| » Defeated Mariners (29-38), 5-3 | Hubert H. Humphrey Metrodome (19-14) | 36-30 | |
| » W: Bill Krueger (7-1) L: Rich DeLucia (2-4) S: Rick Aguilera (19) | Second | 3 out |
| Sunday, June 21 |
| » Defeated Mariners (29-39), 5-0 | Hubert H. Humphrey Metrodome (20-14) | 37-30 | Won 2 |
| » W: Willie Banks (1-1) L: Mike Walker (0-1) S: Tom Edens (2) | Second | 2 out |
| Monday, June 22 |
| » Defeated Angels (30-38), 2-0 | Hubert H. Humphrey Metrodome (21-14) | 38-30 | Won 3 |
| » W: John Smiley (7-3) L: Mark Langston (7-5) S: Rick Aguilera (20) | Second | 2 out |
| Tuesday, June 23 |
| » Defeated Angels (30-39), 5-3 | Hubert H. Humphrey Metrodome (22-14) | 39-30 | Won 4 |
| » W: Scott Erickson (5-5) L: Bert Blyleven (3-1) S: Rick Aguilera (21) | Second | 2 out |
| Wednesday, June 24 |
| » Defeated Angels (30-40), 11-0 | Hubert H. Humphrey Metrodome (23-14) | 40-30 | Won 5 |
| » W: Kevin Tapani (7-5) L: Chuck Finley (2-7) | Second | 2 out |
| Thursday, June 25 |
| » Lost to Athletics (43-28), 5-1 | Oakland-Alameda County Stadium (0-1) | 40-31 | |
| » W: Bob Welch (4-4) L: Bill Krueger (7-2) S: Dennis Eckersley (25) | Second | 3 out |
| Friday, June 26 |
| » Defeated Athletics (43-29), 4-3 | Oakland-Alameda County Stadium (1-1) | 41-31 | |
| » W: Willie Banks (2-1) L: Mike Moore (7-7) S: Rick Aguilera (22) | Second | 2 out |
| Saturday, June 27 |
| » Defeated Athletics (43-30), 12-2 | Oakland-Alameda County Stadium (2-1) | 42-31 | Won 2 |
| » W: John Smiley (8-3) L: Ron Darling (7-5) | Second | 1 out |
| Sunday, June 28 |
| » Defeated Athletics (43-31), 10-2 | Oakland-Alameda County Stadium (3-1) | 43-31 | Won 3 |
| » W: Scott Erickson (6-5) L: Kevin Campbell (2-1) | First | -- |
| Monday, June 29 |
| » Defeated Angels (32-43), 5-1 | Anaheim Stadium (1-0) | 44-31 | Won 4 |
| » W: Kevin Tapani (8-5) L: Chuck Finley (2-8) | First | -- |
| Tuesday, June 30 |
| » Defeated Angels (32-44), 2-0 | Anaheim Stadium (2-0) | 45-31 | Won 5 |
| » W: Bill Krueger (8-2) L: Julio Valera (4-7) | First | -- |
| Wednesday, July 1 |
| » Defeated Angels (32-45), 2-1 | Anaheim Stadium (3-0) | 46-31 | Won 6 |
| » W: Willie Banks (3-1) L: Jim Abbott (4-10) S: Rick Aguilera (23) | First | -- |
| Friday, July 3 |
| » Lost to Orioles (46-32), 6-1 | Hubert H. Humphrey Metrodome (23-15) | 46-32 | |
| » W: Mike Mussina (9-3) L: John Smiley (8-4) | First | -- |
| Saturday, July 4 |
| » Defeated Orioles (46-33), 3-2 | Hubert H. Humphrey Metrodome (24-15) | 47-32 | |
| » W: Carl Willis (2-2) L: Gregg Olson (1-3) | First | -- |
| Sunday, July 5 |
| » Defeated Orioles (46-34), 2-1 | Hubert H. Humphrey Metrodome (25-15) | 48-32 | Won 2 |
| » W: Kevin Tapani (9-5) L: Rick Sutcliffe (10-7) | First | -- |
| Monday, July 6 |
| » Defeated Yankees (40-41), 10-5 | Yankee Stadium (3-1) | 49-32 | Won 3 |
| » W: Carl Willis (3-2) L: Tim Leary (5-6) S: Mark Guthrie (2) | First | -- |
| Tuesday, July 7 |
| » Lost to Yankees (41-41), 2-1 | Yankee Stadium (3-2) | 49-33 | |
| » W: Rich Monteleone (5-1) L: Willie Banks (3-2) S: John Habyan (5) | First | -- |
| Wednesday, July 8 |
| » Defeated Yankees (41-42), 3-2 | Yankee Stadium (4-2) | 50-33 | |
| » W: John Smiley (9-4) L: Melido Perez (8-7) S: Rick Aguilera (24) | First | -- |
| Thursday, July 9 |
| » Lost to Orioles (49-35), 4-2 | Oriole Park at Camden Yards (0-3) | 50-34 | |
| » W: Arthur Rhodes (1-0) L: Scott Erickson (6-6) S: Alan Mills (1) | First | -- |
| Friday, July 10 |
| » Defeated Orioles (49-36), 5-2 | Oriole Park at Camden Yards (1-3) | 51-34 | |
| » W: Kevin Tapani (10-5) L: Rick Sutcliffe (10-8) S: Rick Aguilera (25) | First | -- |
| Saturday, July 11 |
| » Defeated Orioles (49-37), 6-5 | Oriole Park at Camden Yards (2-3) | 52-34 | Won 2 |
| » W: Bill Krueger (9-2) L: Ben McDonald (8-6) S: Rick Aguilera (26) | First | -- |
| Sunday, July 12 |
| » Defeated Orioles (49-38), 9-4 | Oriole Park at Camden Yards (3-3) | 53-34 | Won 3 |
| » W: Tom Edens (5-0) L: Bob Milacki (5-7) | First | -- |
| Thursday, July 16 |
| » Defeated Red Sox (42-44), 7-6 | Hubert H. Humphrey Metrodome (26-15) | 54-34 | Won 4 |
| » W: Carl Willis (4-2) L: Mike Gardiner (3-10) S: Rick Aguilera (27) | First | -- |
| Friday, July 17 |
| » Defeated Red Sox (42-45), 3-2 | Hubert H. Humphrey Metrodome (27-15) | 55-34 | Won 5 |
| » W: Bob Kipper (3-3) L: Greg Harris (2-5) | First | -- |
| Saturday, July 18 |
| » Lost to Red Sox (43-45), 1-0 | Hubert H. Humphrey Metrodome (27-16) | 55-35 | |
| » W: Roger Clemens (10-6) L: Scott Erickson (6-7) | First | -- |
| Sunday, July 19 |
| » Defeated Red Sox (43-46), 7-5 | Hubert H. Humphrey Metrodome (28-16) | 56-35 | |
| » W: Mark Guthrie (2-2) L: Greg Harris (2-6) S: Rick Aguilera (28) | First | -- |
| Monday, July 20 |
| » Lost to Indians (38-55), 5-1 | Hubert H. Humphrey Metrodome (28-17) | 56-36 | |
| » W: Dennis Cook (3-5) L: Willie Banks (3-3) S: Steve Olin (17) | First | -- |
| Tuesday, July 21 |
| » Lost to Indians (39-55), 5-2 | Hubert H. Humphrey Metrodome (28-18) | 56-37 | Lost 2 |
| » W: Jose Mesa (4-9) L: Kevin Tapani (10-6) S: Steve Olin (18) | First | -- |
| Wednesday, July 22 |
| » Defeated Indians (39-56), 2-1 | Hubert H. Humphrey Metrodome (29-18) | 57-37 | |
| » W: John Smiley (10-4) L: Charles Nagy (11-5) | First | -- |
| Friday, July 24 |
| » Defeated Red Sox (44-49), 5-0 | Fenway Park (2-1) | 58-37 | Won 2 |
| » W: Scott Erickson (7-7) L: Roger Clemens (10-7) | First | -- |
| » Lost to Red Sox (45-49), 5-4 | Fenway Park (2-2) | 58-38 | |
| » W: Daryl Irvine (2-0) L: Carl Willis (4-3) | First | -- |
| Saturday, July 25 |
| » Defeated Red Sox (45-50), 3-2 | Fenway Park (3-2) | 59-38 | |
| » W: Willie Banks (4-3) L: Danny Darwin (5-5) S: Rick Aguilera (29) | First | -- |
| Sunday, July 26 |
| » Defeated Red Sox (45-51), 8-2 | Fenway Park (4-2) | 60-38 | Won 2 |
| » W: Kevin Tapani (11-6) L: Joe Hesketh (4-8) S: Mark Guthrie (3) | First | -- |
| Monday, July 27 |
| » Lost to Athletics (58-41), 9-1 | Hubert H. Humphrey Metrodome (29-19) | 60-39 | |
| » W: Bob Welch (8-5) L: John Smiley (10-5) | First | -- |
| Tuesday, July 28 |
| » Lost to Athletics (59-41), 12-10 | Hubert H. Humphrey Metrodome (29-20) | 60-40 | Lost 2 |
| » W: Gene Nelson (3-1) L: Tom Edens (5-1) S: Dennis Eckersley (32) | First | -- |
| Wednesday, July 29 |
| » Lost to Athletics (60-41), 5-4 | Hubert H. Humphrey Metrodome (29-21) | 60-41 | Lost 3 |
| » W: Jeff Parrett (7-0) L: Rick Aguilera (1-5) S: Dennis Eckersley (33) | First | -- |
| Thursday, July 30 |
| » Lost to Brewers (55-46), 5-3 | Hubert H. Humphrey Metrodome (29-22) | 60-42 | Lost 4 |
| » W: Chris Bosio (8-5) L: Willie Banks (4-4) | Second | ½ out |
| Friday, July 31 |
| » Defeated Brewers (55-47), 4-1 | Hubert H. Humphrey Metrodome (30-22) | 61-42 | |
| » W: Kevin Tapani (12-6) L: Bill Wegman (9-8) S: Tom Edens (3) | First | -- |
| Saturday, August 1 |
| » Defeated Brewers (55-48), 9-6 | Hubert H. Humphrey Metrodome (31-22) | 62-42 | Won 2 |
| » W: John Smiley (11-5) L: Jaime Navarro (11-7) | First | -- |
| Sunday, August 2 |
| » Defeated Brewers (55-49), 5-0 | Hubert H. Humphrey Metrodome (32-22) | 63-42 | Won 3 |
| » W: Scott Erickson (8-7) L: Ricky Bones (6-8) | First | -- |
| Monday, August 3 |
| » Major-league debuts: Doug Linton (Blue Jays) |
| Tuesday, August 4 |
| » Lost to White Sox (53-51), 19-11 | Comiskey Park II (1-3) | 63-43 | |
| » W: Wilson Alvarez (3-3) L: Bill Krueger (9-3) S: Donn Pall (1) | First | -- |
| Wednesday, August 5 |
| » Lost to White Sox (54-51), 9-5 | Comiskey Park II (1-4) | 63-44 | Lost 2 |
| » W: Charlie Hough (5-7) L: Kevin Tapani (12-7) | Second | 1 out |
| Thursday, August 6 |
| » Lost to White Sox (55-51), 5-3 | Comiskey Park II (1-5) | 63-45 | Lost 3 |
| » W: Kirk McCaskill (8-8) L: John Smiley (11-6) S: Roberto Hernandez (2) | Second | 2 out |
| Saturday, August 8 |
| » Lost to Brewers (59-49), 4-0 | County Stadium (2-2) | 63-46 | Lost 4 |
| » W: Cal Eldred (2-1) L: Scott Erickson (8-8) | Second | 3 out |
| » Defeated Brewers (59-50), 3-1 | County Stadium (3-2) | 64-46 | |
| » W: Bill Krueger (10-3) L: Ricky Bones (6-9) S: Rick Aguilera (30) | Second | 3 out |
| Sunday, August 9 |
| » Lost to Brewers (60-50), 4-2 | County Stadium (3-3) | 64-47 | |
| » W: Chris Bosio (10-5) L: David West (0-1) S: Doug Henry (23) | Second | 3 out |
| Monday, August 10 |
| » Defeated Rangers (57-58), 7-5 | Hubert H. Humphrey Metrodome (33-22) | 65-47 | |
| » W: Kevin Tapani (13-7) L: Bobby Witt (9-10) S: Rick Aguilera (31) | Second | 3 out |
| Tuesday, August 11 |
| » Defeated Rangers (57-59), 3-2 | Hubert H. Humphrey Metrodome (34-22) | 66-47 | Won 2 |
| » W: John Smiley (12-6) L: Kenny Rogers (1-5) | Second | 2 out |
| » Major-league debuts: David Hulse (Rangers) |
| Wednesday, August 12 |
| » Lost to Rangers (58-59), 5-3 | Hubert H. Humphrey Metrodome (34-23) | 66-48 | |
| » W: Kevin Brown (16-7) L: Rick Aguilera (1-6) S: Jeff Russell (27) | Second | 3 out |
| Thursday, August 13 |
| » Lost to Rangers (59-59), 6-1 | Hubert H. Humphrey Metrodome (34-24) | 66-49 | Lost 2 |
| » W: Jose Guzman (10-9) L: Scott Erickson (8-9) | Second | 4 out |
| Friday, August 14 |
| » Defeated Mariners (45-72), 9-6 | Kingdome (3-2) | 67-49 | |
| » W: David West (1-1) L: Calvin Jones (3-3) S: Rick Aguilera (32) | Second | 3 out |
| Saturday, August 15 |
| » Lost to Mariners (46-72), 3-2 | Kingdome (3-3) | 67-50 | |
| » W: Randy Johnson (9-12) L: Tom Edens (5-2) | Second | 4 out |
| Sunday, August 16 |
| » Lost to Mariners (47-72), 8-7 | Kingdome (3-4) | 67-51 | Lost 2 |
| » W: Jeff Nelson (1-4) L: Mark Guthrie (2-3) | Second | 5 out |
| Tuesday, August 18 |
| » Lost to Indians (54-65), 8-1 | Cleveland Stadium (2-2) | 67-52 | Lost 3 |
| » W: Jose Mesa (5-9) L: Scott Erickson (8-10) S: Ted Power (5) | Second | 5 out |
| Wednesday, August 19 |
| » Lost to Indians (55-65), 5-1 | Cleveland Stadium (2-3) | 67-53 | Lost 4 |
| » W: Charles Nagy (13-8) L: Bill Krueger (10-4) | Second | 5 out |
| » Major-league debuts: Mike Trombley (Twins) |
| Thursday, August 20 |
| » Lost to Indians (56-65), 2-1 | Cleveland Stadium (2-4) | 67-54 | Lost 5 |
| » W: Eric Plunk (4-2) L: Kevin Tapani (13-8) | Second | 6 out |
| Friday, August 21 |
| » Defeated Blue Jays (70-52), 5-1 | Hubert H. Humphrey Metrodome (35-24) | 68-54 | |
| » W: John Smiley (13-6) L: Todd Stottlemyre (7-9) | Second | 5 out |
| Saturday, August 22 |
| » Lost to Blue Jays (71-52), 4-2 | Hubert H. Humphrey Metrodome (35-25) | 68-55 | |
| » W: Jack Morris (16-5) L: David West (1-2) S: Tom Henke (22) | Second | 6 out |
| Sunday, August 23 |
| » Defeated Blue Jays (71-53), 2-0 | Hubert H. Humphrey Metrodome (36-25) | 69-55 | |
| » W: Scott Erickson (9-10) L: Jimmy Key (8-11) | Second | 6 out |
| Monday, August 24 |
| » Lost to Tigers (60-66), 6-2 | Hubert H. Humphrey Metrodome (36-26) | 69-56 | |
| » W: Eric King (4-4) L: Bill Krueger (10-5) | Second | 7 out |
| Tuesday, August 25 |
| » Lost to Tigers (61-66), 4-3 | Hubert H. Humphrey Metrodome (36-27) | 69-57 | Lost 2 |
| » W: Dave Haas (3-1) L: Kevin Tapani (13-9) S: Mike Henneman (21) | Second | 7 out |
| Wednesday, August 26 |
| » Defeated Tigers (61-67), 1-0 | Hubert H. Humphrey Metrodome (37-27) | 70-57 | |
| » W: John Smiley (14-6) L: John Kiely (4-2) | Second | 6 out |
| Thursday, August 27 |
| » Lost to Yankees (60-68), 5-0 | Hubert H. Humphrey Metrodome (37-28) | 70-58 | |
| » W: Melido Perez (11-13) L: David West (1-3) | Second | 6½ out |
| Friday, August 28 |
| » Defeated Yankees (60-69), 4-3 | Hubert H. Humphrey Metrodome (38-28) | 71-58 | |
| » W: Carl Willis (5-3) L: Greg Cadaret (4-8) | Second | 6½ out |
| Saturday, August 29 |
| » Lost to Yankees (61-69), 6-3 | Hubert H. Humphrey Metrodome (38-29) | 71-59 | |
| » W: Bob Wickman (1-0) L: Bill Krueger (10-6) S: Steve Farr (22) | Second | 7½ out |
| Sunday, August 30 |
| » Defeated Yankees (61-70), 5-3 | Hubert H. Humphrey Metrodome (39-29) | 72-59 | |
| » W: Kevin Tapani (14-9) L: Sam Militello (3-1) S: Rick Aguilera (33) | Second | 7½ out |
| Monday, August 31 |
| » Defeated Tigers (63-69), 5-3 | Tiger Stadium (3-1) | 73-59 | Won 2 |
| » W: Gary Wayne (2-2) L: Mike Henneman (1-6) S: Rick Aguilera (34) | Second | 6½ out |
| Tuesday, September 1 |
| » Defeated Tigers (63-70), 5-4 | Tiger Stadium (4-1) | 74-59 | Won 3 |
| » W: Carl Willis (6-3) L: Les Lancaster (3-4) S: Rick Aguilera (35) | Second | 5½ out |
| Wednesday, September 2 |
| » Defeated Tigers (63-71), 4-2 | Tiger Stadium (5-1) | 75-59 | Won 4 |
| » W: Scott Erickson (10-10) L: Walt Terrell (5-10) S: Rick Aguilera (36) | Second | 4½ out |
| Friday, September 4 |
| » Lost to Blue Jays (77-58), 16-5 | Skydome (2-2) | 75-60 | |
| » W: David Cone (14-8) L: Kevin Tapani (14-10) | Second | 4½ out |
| Saturday, September 5 |
| » Lost to Blue Jays (78-58), 7-3 | Skydome (2-3) | 75-61 | Lost 2 |
| » W: Juan Guzman (13-3) L: John Smiley (14-7) | Second | 4½ out |
| Sunday, September 6 |
| » Lost to Blue Jays (79-58), 4-2 | Skydome (2-4) | 75-62 | Lost 3 |
| » W: Todd Stottlemyre (10-9) L: Mike Trombley (0-1) S: Tom Henke (25) | Second | 5½ out |
| Monday, September 7 |
| » Defeated Mariners (56-82), 4-2 | Hubert H. Humphrey Metrodome (40-29) | 76-62 | |
| » W: Scott Erickson (11-10) L: Tim Leary (6-8) S: Rick Aguilera (37) | Second | 4½ out |
| Tuesday, September 8 |
| » Defeated Mariners (56-83), 8-4 | Hubert H. Humphrey Metrodome (41-29) | 77-62 | Won 2 |
| » W: Gary Wayne (3-2) L: Calvin Jones (3-4) | Second | 4½ out |
| Wednesday, September 9 |
| » Defeated Mariners (56-84), 6-2 | Hubert H. Humphrey Metrodome (42-29) | 78-62 | Won 3 |
| » W: Kevin Tapani (15-10) L: Dave Fleming (15-8) S: Mark Guthrie (4) | Second | 4½ out |
| Friday, September 11 |
| » Lost to Angels (64-77), 8-0 | Hubert H. Humphrey Metrodome (42-30) | 78-63 | |
| » W: Jim Abbott (7-13) L: John Smiley (14-8) | Second | 6 out |
| » Major-league debuts: Derek Parks (Twins) |
| Saturday, September 12 |
| » Defeated Angels (64-78), 7-2 | Hubert H. Humphrey Metrodome (43-30) | 79-63 | |
| » W: Mike Trombley (1-1) L: Bert Blyleven (8-8) S: Mark Guthrie (5) | Second | 6 out |
| Sunday, September 13 |
| » Defeated Angels (64-79), 6-2 | Hubert H. Humphrey Metrodome (44-30) | 80-63 | Won 2 |
| » W: Scott Erickson (12-10) L: Julio Valera (7-10) | Second | 6 out |
| Monday, September 14 |
| » Lost to Athletics (87-57), 3-2 | Oakland-Alameda County Stadium (3-2) | 80-64 | |
| » W: Jim Corsi (4-1) L: Tom Edens (5-3) S: Dennis Eckersley (46) | Second | 7 out |
| Tuesday, September 15 |
| » Lost to Athletics (88-57), 2-1 | Oakland-Alameda County Stadium (3-3) | 80-65 | Lost 2 |
| » W: Ron Darling (14-9) L: Pat Mahomes (3-3) S: Dennis Eckersley (47) | Second | 8 out |
| » Major-league debuts: Bernardo Brito (Twins) |
| Wednesday, September 16 |
| » Lost to Athletics (89-57), 4-2 | Oakland-Alameda County Stadium (3-4) | 80-66 | Lost 3 |
| » W: Bobby Witt (10-13) L: John Smiley (14-9) S: Jeff Russell (30) | Second | 9 out |
| Thursday, September 17 |
| » Defeated Angels (66-80), 2-1 | Anaheim Stadium (4-0) | 81-66 | |
| » W: Mike Trombley (2-1) L: Jim Abbott (7-14) S: Rick Aguilera (38) | Second | 8½ out |
| Friday, September 18 |
| » Defeated Angels (66-81), 4-1 | Anaheim Stadium (5-0) | 82-66 | Won 2 |
| » W: Scott Erickson (13-10) L: Bert Blyleven (8-9) S: Rick Aguilera (39) | Second | 8½ out |
| Saturday, September 19 |