| Monday, April 6 |
| » Lost to Blue Jays (1-0), 4-2 | Tiger Stadium (0-1) | 0-1 | |
| » W: Jack Morris (1-0) L: Bill Gullickson (0-1) | Third | 1 out |
| Wednesday, April 8 |
| » Lost to Blue Jays (2-0), 10-9 | Tiger Stadium (0-2) | 0-2 | Lost 2 |
| » W: Tom Henke (1-0) L: Frank Tanana (0-1) S: Duane Ward (1) | Fifth | 2 out |
| » Major-league debuts: John Doherty (Tigers) Ricky Trlicek (Blue Jays) |
| Thursday, April 9 |
| » Lost to Blue Jays (3-0), 3-1 | Tiger Stadium (0-3) | 0-3 | Lost 3 |
| » W: Juan Guzman (1-0) L: Walt Terrell (0-1) S: Duane Ward (2) | Sixth | 3 out |
| Friday, April 10 |
| » Lost to Yankees (3-0), 7-3 | Tiger Stadium (0-4) | 0-4 | Lost 4 |
| » W: Melido Perez (1-0) L: Eric King (0-1) | Sixth | 4 out |
| Saturday, April 11 |
| » Lost to Yankees (4-0), 8-1 | Tiger Stadium (0-5) | 0-5 | Lost 5 |
| » W: Tim Leary (1-0) L: Bill Gullickson (0-2) | Sixth | 5 out |
| » Major-league debuts: Andy Stankiewicz (Yankees) |
| Sunday, April 12 |
| » Lost to Yankees (5-0), 5-1 | Tiger Stadium (0-6) | 0-6 | Lost 6 |
| » W: Scott Sanderson (2-0) L: Scott Aldred (0-1) S: John Habyan (1) | Fifth | 6 out |
| Monday, April 13 |
| » Defeated Indians (2-5), 7-5 | Cleveland Stadium (1-0) | 1-6 | |
| » W: Mark Leiter (1-0) L: Rod Nichols (0-1) S: Mike Henneman (1) | Sixth | 5½ out |
| Tuesday, April 14 |
| » Lost to Indians (3-5), 8-7 | Cleveland Stadium (1-1) | 1-7 | |
| » W: Ted Power (1-0) L: Les Lancaster (0-1) S: Steve Olin (1) | Sixth | 6 out |
| Wednesday, April 15 |
| » Defeated Indians (3-6), 8-1 | Cleveland Stadium (2-1) | 2-7 | |
| » W: Eric King (1-1) L: Eric Bell (0-2) | Seventh | 6 out |
| Thursday, April 16 |
| » Defeated Indians (3-7), 13-4 | Cleveland Stadium (3-1) | 3-7 | Won 2 |
| » W: Bill Gullickson (1-2) L: Dennis Cook (0-1) | Sixth | 6 out |
| Friday, April 17 |
| » Lost to Orioles (4-5), 8-0 | Oriole Park at Camden Yards (0-1) | 3-8 | |
| » W: Rick Sutcliffe (2-1) L: Scott Aldred (0-2) | Seventh | 6 out |
| Saturday, April 18 |
| » Lost to Orioles (5-5), 6-1 | Oriole Park at Camden Yards (0-2) | 3-9 | Lost 2 |
| » W: Mike Mussina (1-0) L: Frank Tanana (0-2) | Sixth | 7 out |
| Sunday, April 19 |
| » Lost to Orioles (6-5), 3-2 | Oriole Park at Camden Yards (0-3) | 3-10 | Lost 3 |
| » W: Bob Milacki (1-1) L: Walt Terrell (0-2) S: Gregg Olson (2) | Seventh | 7 out |
| Monday, April 20 |
| » Lost to Orioles (7-5), 12-4 | Oriole Park at Camden Yards (0-4) | 3-11 | Lost 4 |
| » W: Alan Mills (1-0) L: Eric King (1-2) S: Todd Frohwirth (1) | Sixth | 8 out |
| Tuesday, April 21 |
| » Defeated Rangers (9-6), 4-2 | Arlington Stadium (1-0) | 4-11 | |
| » W: Bill Gullickson (2-2) L: Bobby Witt (1-2) S: Mike Henneman (2) | Seventh | 8 out |
| Wednesday, April 22 |
| » Defeated Rangers (9-7), 12-8 | Arlington Stadium (2-0) | 5-11 | Won 2 |
| » W: Mark Leiter (2-0) L: Jeff Robinson (1-2) | Seventh | 7 out |
| Thursday, April 23 |
| » Defeated Rangers (9-8), 11-5 | Arlington Stadium (3-0) | 6-11 | Won 3 |
| » W: Les Lancaster (1-1) L: Kevin Brown (3-1) S: John Doherty (1) | Fourth | 7 out |
| Friday, April 24 |
| » Lost to White Sox (9-6), 9-1 | Tiger Stadium (0-7) | 6-12 | |
| » W: Jack McDowell (4-0) L: Walt Terrell (0-3) | Fifth | 8 out |
| Saturday, April 25 |
| Former Tiger Bob Hazle dies in Columbia, SC at the age of 62. |
| Sunday, April 26 |
| » Lost to White Sox (10-6), 7-6 | Tiger Stadium (0-8) | 6-13 | Lost 2 |
| » W: Greg Hibbard (4-0) L: Eric King (1-3) S: Bobby Thigpen (5) | Seventh | 8½ out |
| Tuesday, April 28 |
| » Defeated Mariners (10-11), 4-1 | Tiger Stadium (1-8) | 7-13 | |
| » W: Bill Gullickson (3-2) L: Russ Swan (2-3) | Fifth | 7½ out |
| Thursday, April 30 |
| » Lost to Athletics (14-8), 10-6 | Tiger Stadium (1-9) | 7-14 | |
| » W: Vince Horsman (1-0) L: Mark Leiter (2-1) S: Dennis Eckersley (8) | Sixth | 8 out |
| Friday, May 1 |
| » Lost to Athletics (15-8), 7-6 | Tiger Stadium (1-10) | 7-15 | Lost 2 |
| » W: Jeff Parrett (4-0) L: Mike Henneman (0-1) S: Dennis Eckersley (9) | Sixth | 8 out |
| Saturday, May 2 |
| » Defeated Athletics (15-9), 5-3 | Tiger Stadium (2-10) | 8-15 | |
| » W: Frank Tanana (1-2) L: Bob Welch (0-1) S: Mike Henneman (3) | Seventh | 7 out |
| Sunday, May 3 |
| » Defeated Athletics (15-10), 8-4 | Tiger Stadium (3-10) | 9-15 | Won 2 |
| » W: Eric King (2-3) L: Mike Moore (4-1) S: Mike Henneman (4) | Sixth | 7 out |
| Monday, May 4 |
| » Defeated Angels (13-12), 6-2 | Tiger Stadium (4-10) | 10-15 | Won 3 |
| » W: Bill Gullickson (4-2) L: Jim Abbott (1-4) | Sixth | 7 out |
| Tuesday, May 5 |
| » Defeated Angels (13-13), 2-1 | Tiger Stadium (5-10) | 11-15 | Won 4 |
| » W: John Doherty (1-0) L: Mark Eichhorn (0-2) | Sixth | 7 out |
| Wednesday, May 6 |
| » Lost to Athletics (16-12), 5-2 | Oakland-Alameda County Stadium (0-1) | 11-16 | |
| » W: Dave Stewart (2-2) L: Walt Terrell (0-4) S: Dennis Eckersley (10) | Sixth | 8 out |
| Thursday, May 7 |
| » Lost to Athletics (17-12), 6-2 | Oakland-Alameda County Stadium (0-2) | 11-17 | Lost 2 |
| » W: Bob Welch (1-1) L: Frank Tanana (1-3) S: Dennis Eckersley (11) | Seventh | 9 out |
| Friday, May 8 |
| » Defeated Mariners (11-18), 7-6 | Kingdome (1-0) | 12-17 | |
| » W: Les Lancaster (2-1) L: Mike Schooler (0-3) S: Mike Henneman (5) | Sixth | 8 out |
| Saturday, May 9 |
| » Defeated Mariners (11-19), 13-0 | Kingdome (2-0) | 13-17 | Won 2 |
| » W: Bill Gullickson (5-2) L: Russ Swan (2-5) | Fifth | 7 out |
| Sunday, May 10 |
| » Lost to Mariners (12-19), 6-2 | Kingdome (2-1) | 13-18 | |
| » W: Dave Fleming (4-1) L: Scott Aldred (0-3) | Sixth | 8 out |
| Former Tiger Tom Seats dies in San Ramon, CA at the age of 82. |
| Tuesday, May 12 |
| » Defeated Angels (17-15), 4-2 | Anaheim Stadium (1-0) | 14-18 | |
| » W: Frank Tanana (2-3) L: Bryan Harvey (0-2) S: Mike Henneman (6) | Sixth | 8 out |
| Wednesday, May 13 |
| » Lost to Angels (18-15), 7-5 | Anaheim Stadium (1-1) | 14-19 | |
| » W: Steve Frey (2-0) L: Walt Terrell (0-5) S: Bryan Harvey (11) | Sixth | 9 out |
| Friday, May 15 |
| » Defeated Royals (10-23), 8-2 | Royals Stadium (1-0) | 15-19 | |
| » W: John Doherty (2-0) L: Curt Young (1-2) | Sixth | 8½ out |
| Saturday, May 16 |
| » Defeated Royals (10-24), 7-2 | Royals Stadium (2-0) | 16-19 | Won 2 |
| » W: Scott Aldred (1-3) L: Tom Gordon (0-5) | Sixth | 8 out |
| » Major-league debuts: Kurt Knudsen (Tigers) |
| Sunday, May 17 |
| » Lost to Royals (11-24), 2-1 | Royals Stadium (2-1) | 16-20 | |
| » W: Mark Gubicza (4-2) L: Walt Terrell (0-6) | Sixth | 8 out |
| Monday, May 18 |
| » Lost to Brewers (17-18), 9-1 | Tiger Stadium (5-11) | 16-21 | Lost 2 |
| » W: Bill Wegman (3-4) L: Eric King (2-4) | Sixth | 8 out |
| » Major-league debuts: David Nilsson (Brewers) |
| Tuesday, May 19 |
| » Defeated Brewers (17-19), 3-0 | Tiger Stadium (6-11) | 17-21 | |
| » W: Frank Tanana (3-3) L: Ron Robinson (0-1) S: Mike Henneman (7) | Sixth | 7 out |
| Wednesday, May 20 |
| » Defeated Brewers (17-20), 4-3 | Tiger Stadium (7-11) | 18-21 | Won 2 |
| » W: Kurt Knudsen (1-0) L: Doug Henry (0-1) | Fifth | 6½ out |
| Thursday, May 21 |
| » Lost to Brewers (18-20), 7-3 | Tiger Stadium (7-12) | 18-22 | |
| » W: Edwin Nunez (1-1) L: Scott Aldred (1-4) | Sixth | 7 out |
| Friday, May 22 |
| » Defeated Twins (21-19), 6-3 | Tiger Stadium (8-12) | 19-22 | |
| » W: Mark Leiter (3-1) L: John Smiley (3-3) S: Mike Henneman (8) | Sixth | 7 out |
| Saturday, May 23 |
| » Lost to Twins (22-19), 6-5 | Tiger Stadium (8-13) | 19-23 | |
| » W: Kevin Tapani (4-4) L: John Doherty (2-1) S: Rick Aguilera (13) | Sixth | 7 out |
| Sunday, May 24 |
| » Lost to Twins (23-19), 15-0 | Tiger Stadium (8-14) | 19-24 | Lost 2 |
| » W: Bill Krueger (5-0) L: Frank Tanana (3-4) | Sixth | 7½ out |
| Tuesday, May 26 |
| » Defeated Royals (14-29), 8-1 | Tiger Stadium (9-14) | 20-24 | |
| » W: Bill Gullickson (6-2) L: Hipolito Pichardo (1-2) | Sixth | 7 out |
| Wednesday, May 27 |
| » Defeated Royals (14-30), 11-2 | Tiger Stadium (10-14) | 21-24 | Won 2 |
| » W: Scott Aldred (2-4) L: Mike Boddicker (0-3) | Sixth | 6 out |
| » Major-league debuts: Phil Clark (Tigers) |
| Thursday, May 28 |
| » Lost to Royals (15-30), 5-1 | Tiger Stadium (10-15) | 21-25 | |
| » W: Mark Gubicza (5-3) L: Mark Leiter (3-2) | Sixth | 6½ out |
| Friday, May 29 |
| » Lost to Twins (25-20), 17-5 | Hubert H. Humphrey Metrodome (0-1) | 21-26 | Lost 2 |
| » W: Kevin Tapani (5-4) L: Kevin Ritz (0-1) S: Carl Willis (1) | Sixth | 7½ out |
| Saturday, May 30 |
| » Lost to Twins (26-20), 7-5 | Hubert H. Humphrey Metrodome (0-2) | 21-27 | Lost 3 |
| » W: Tom Edens (3-0) L: Mike Henneman (0-2) S: Rick Aguilera (14) | Sixth | 8½ out |
| Sunday, May 31 |
| » Lost to Twins (27-20), 4-1 | Hubert H. Humphrey Metrodome (0-3) | 21-28 | Lost 4 |
| » W: Scott Erickson (3-4) L: Bill Gullickson (6-3) S: Mark Guthrie (1) | Sixth | 9½ out |
| Monday, June 1 |
| » Lost to Brewers (24-24), 6-2 | County Stadium (0-1) | 21-29 | Lost 5 |
| » W: Jaime Navarro (5-4) L: Scott Aldred (2-5) | Sixth | 10½ out |
| Tuesday, June 2 |
| » Lost to Brewers (25-24), 5-4 | County Stadium (0-2) | 21-30 | Lost 6 |
| » W: Jesse Orosco (2-1) L: Mark Leiter (3-3) S: Doug Henry (8) | Sixth | 11½ out |
| Wednesday, June 3 |
| » Defeated Brewers (25-25), 10-4 | County Stadium (1-2) | 22-30 | |
| » W: Kevin Ritz (1-1) L: Bill Wegman (5-5) | Sixth | 10½ out |
| Thursday, June 4 |
| » Defeated Yankees (27-25), 6-2 | Yankee Stadium (1-0) | 23-30 | Won 2 |
| » W: Frank Tanana (4-4) L: Scott Sanderson (4-3) | Sixth | 10 out |
| Saturday, June 6 |
| » Defeated Yankees (27-26), 6-2 | Yankee Stadium (2-0) | 24-30 | Won 3 |
| » W: Bill Gullickson (7-3) L: Scott Kamieniecki (1-3) | Sixth | 9½ out |
| Sunday, June 7 |
| » Lost to Yankees (28-26), 6-5 | Yankee Stadium (2-1) | 24-31 | |
| » W: Melido Perez (5-4) L: Walt Terrell (0-7) S: Steve Farr (7) | Sixth | 9½ out |
| Monday, June 8 |
| » Defeated Indians (22-35), 9-2 | Tiger Stadium (11-15) | 25-31 | |
| » W: Mark Leiter (4-3) L: Scott Scudder (4-6) S: Kurt Knudsen (1) | Sixth | 9½ out |
| Tuesday, June 9 |
| » Lost to Indians (23-35), 6-1 | Tiger Stadium (11-16) | 25-32 | |
| » W: Denis Boucher (2-1) L: Frank Tanana (4-5) | Sixth | 10½ out |
| Wednesday, June 10 |
| » Lost to Indians (24-35), 4-2 | Tiger Stadium (11-17) | 25-33 | Lost 2 |
| » W: Steve Olin (1-3) L: Mike Munoz (0-1) | Sixth | 11½ out |
| Thursday, June 11 |
| » Lost to Orioles (36-22), 7-5 | Tiger Stadium (11-18) | 25-34 | Lost 3 |
| » W: Alan Mills (3-1) L: Bill Gullickson (7-4) S: Gregg Olson (17) | Sixth | 12½ out |
| Friday, June 12 |
| » Lost to Orioles (37-22), 6-0 | Tiger Stadium (11-19) | 25-35 | Lost 4 |
| » W: Mike Mussina (8-1) L: Scott Aldred (2-6) | Sixth | 12½ out |
| Saturday, June 13 |
| » Defeated Orioles (37-23), 15-1 | Tiger Stadium (12-19) | 26-35 | |
| » W: Mark Leiter (5-3) L: Bob Milacki (5-4) | Sixth | 11½ out |
| Sunday, June 14 |
| » Defeated Orioles (37-24), 7-4 | Tiger Stadium (13-19) | 27-35 | Won 2 |
| » W: Frank Tanana (5-5) L: Jose Mesa (2-7) S: Mike Henneman (9) | Sixth | 11½ out |
| Tuesday, June 16 |
| » Defeated Blue Jays (39-25), 4-3 | Skydome (1-0) | 28-35 | Won 3 |
| » W: Bill Gullickson (8-4) L: Jimmy Key (4-5) S: Mike Henneman (10) | Sixth | 10½ out |
| Wednesday, June 17 |
| » Lost to Blue Jays (40-25), 6-2 | Skydome (1-1) | 28-36 | |
| » W: Jack Morris (8-3) L: Kevin Ritz (1-2) S: Duane Ward (8) | Sixth | 11½ out |
| Thursday, June 18 |
| » Defeated Blue Jays (40-26), 14-10 | Skydome (2-1) | 29-36 | |
| » W: Mike Munoz (1-1) L: Mike Timlin (0-1) S: Mike Henneman (11) | Sixth | 10½ out |
| Friday, June 19 |
| » Defeated White Sox (29-35), 8-3 | Comiskey Park II (1-0) | 30-36 | Won 2 |
| » W: Walt Terrell (1-7) L: Wilson Alvarez (0-2) | Sixth | 9½ out |
| Saturday, June 20 |
| » Lost to White Sox (30-35), 3-1 | Comiskey Park II (1-1) | 30-37 | |
| » W: Kirk McCaskill (4-6) L: Buddy Groom (0-1) S: Bobby Thigpen (15) | Sixth | 10½ out |
| » Major-league debuts: Buddy Groom (Tigers) |
| Sunday, June 21 |
| » Lost to White Sox (31-35), 6-5 | Comiskey Park II (1-2) | 30-38 | Lost 2 |
| » W: Roberto Hernandez (1-0) L: Walt Terrell (1-8) S: Bobby Thigpen (16) | Sixth | 10½ out |
| Monday, June 22 |
| » Defeated Red Sox (32-34), 4-2 | Tiger Stadium (14-19) | 31-38 | |
| » W: Kurt Knudsen (2-0) L: Danny Darwin (3-4) | Sixth | 10½ out |
| Tuesday, June 23 |
| » Defeated Red Sox (32-35), 11-7 | Tiger Stadium (15-19) | 32-38 | Won 2 |
| » W: John Kiely (1-0) L: Joe Hesketh (3-4) | Sixth | 10 out |
| Wednesday, June 24 |
| » Defeated Red Sox (32-36), 5-1 | Tiger Stadium (16-19) | 33-38 | Won 3 |
| » W: Frank Tanana (6-5) L: Mike Gardiner (3-8) | Sixth | 10 out |
| Thursday, June 25 |
| » Lost to Rangers (40-34), 5-2 | Tiger Stadium (16-20) | 33-39 | |
| » W: Kevin Brown (11-4) L: Buddy Groom (0-2) | Sixth | 10½ out |
| Friday, June 26 |
| » Defeated Rangers (40-35), 4-2 | Tiger Stadium (17-20) | 34-39 | |
| » W: Bill Gullickson (9-4) L: Todd Burns (2-1) S: Mike Henneman (12) | Sixth | 10½ out |
| » Major-league debuts: Dan Peltier (Rangers) |
| Saturday, June 27 |
| » Lost to Rangers (41-35), 10-8 | Tiger Stadium (17-21) | 34-40 | |
| » W: Jose Guzman (7-5) L: Kevin Ritz (1-3) S: Kenny Rogers (5) | Sixth | 10½ out |
| Former Tiger Sandy Amoros dies in Miami, FL at the age of 63. |
| Sunday, June 28 |
| » Lost to Rangers (42-35), 8-4 | Tiger Stadium (17-22) | 34-41 | Lost 2 |
| » W: Nolan Ryan (1-3) L: Mark Leiter (5-4) | Sixth | 10½ out |
| Monday, June 29 |
| » Defeated Red Sox (34-38), 8-3 | Fenway Park (1-0) | 35-41 | |
| » W: Frank Tanana (7-5) L: Joe Hesketh (3-5) S: Kurt Knudsen (2) | Sixth | 10½ out |
| Tuesday, June 30 |
| » Lost to Red Sox (35-38), 8-5 | Fenway Park (1-1) | 35-42 | |
| » W: Daryl Irvine (1-0) L: Mike Henneman (0-3) | Sixth | 10½ out |
| Wednesday, July 1 |
| » Lost to Red Sox (36-38), 6-4 | Fenway Park (1-2) | 35-43 | Lost 2 |
| » W: John Dopson (5-3) L: Bill Gullickson (9-5) S: Jeff Reardon (16) | Sixth | 11½ out |
| Friday, July 3 |
| » Defeated Mariners (31-48), 6-4 | Tiger Stadium (18-22) | 36-43 | |
| » W: Walt Terrell (2-8) L: Randy Johnson (5-8) S: Mike Henneman (13) | Sixth | 12 out |
| » Lost to Mariners (32-48), 11-0 | Tiger Stadium (18-23) | 36-44 | |
| » W: Erik Hanson (6-10) L: Les Lancaster (2-2) | Sixth | 12 out |
| Saturday, July 4 |
| » Lost to Mariners (33-48), 4-3 | Tiger Stadium (18-24) | 36-45 | Lost 2 |
| » W: Mike Schooler (1-5) L: Mike Henneman (0-4) S: Russ Swan (3) | Sixth | 13 out |
| Sunday, July 5 |
| » Defeated Mariners (33-49), 8-5 | Tiger Stadium (19-24) | 37-45 | |
| » W: Walt Terrell (3-8) L: Rich DeLucia (3-5) S: John Doherty (2) | Sixth | 13 out |
| Monday, July 6 |
| » Defeated Mariners (33-50), 5-4 | Tiger Stadium (20-24) | 38-45 | Won 2 |
| » W: John Kiely (2-0) L: Mike Walker (0-3) | Sixth | 13 out |
| Tuesday, July 7 |
| » Defeated Athletics (48-34), 3-2 | Tiger Stadium (21-24) | 39-45 | Won 3 |
| » W: Kevin Ritz (2-3) L: Ron Darling (7-7) S: Mike Henneman (14) | Sixth | 13 out |
| » Major-league debuts: Eric Fox (Athletics) |
| Wednesday, July 8 |
| » Defeated Athletics (48-35), 6-3 | Tiger Stadium (22-24) | 40-45 | Won 4 |
| » W: Les Lancaster (3-2) L: Jim Corsi (1-1) S: Mike Henneman (15) | Sixth | 13 out |
| Thursday, July 9 |
| » Defeated Angels (32-52), 5-4 | Tiger Stadium (23-24) | 41-45 | Won 5 |
| » W: Frank Tanana (8-5) L: Bert Blyleven (3-3) S: Mike Henneman (16) | Fifth | 13 out |
| Friday, July 10 |
| » Lost to Angels (33-52), 6-1 | Tiger Stadium (23-25) | 41-46 | |
| » W: Julio Valera (5-8) L: Buddy Groom (0-3) | Sixth | 13 out |
| Saturday, July 11 |
| » Lost to Angels (34-52), 2-1 | Tiger Stadium (23-26) | 41-47 | Lost 2 |
| » W: Chuck Crim (2-2) L: Bill Gullickson (9-6) S: Joe Grahe (4) | Sixth | 13 out |
| Sunday, July 12 |
| » Lost to Angels (35-52), 5-4 | Tiger Stadium (23-27) | 41-48 | Lost 3 |
| » W: Steve Frey (3-1) L: Mike Henneman (0-5) | Sixth | 13 out |
| Thursday, July 16 |
| » Lost to Athletics (52-36), 4-0 | Oakland-Alameda County Stadium (0-3) | 41-49 | Lost 4 |
| » W: Kelly Downs (2-3) L: Frank Tanana (8-6) | Sixth | 14 out |
| Friday, July 17 |
| » Defeated Athletics (52-37), 4-3 | Oakland-Alameda County Stadium (1-3) | 42-49 | |
| » W: Bill Gullickson (10-6) L: Bob Welch (7-5) S: Kurt Knudsen (3) | Sixth | 13 out |
| Saturday, July 18 |
| » Defeated Athletics (52-38), 5-2 | Oakland-Alameda County Stadium (2-3) | 43-49 | Won 2 |
| » W: Mark Leiter (6-4) L: Mike Moore (10-8) S: Buddy Groom (1) | Sixth | 13 out |
| Sunday, July 19 |
| » Lost to Athletics (53-38), 6-2 | Oakland-Alameda County Stadium (2-4) | 43-50 | |
| » W: Gene Nelson (2-1) L: Kevin Ritz (2-4) | Sixth | 14 out |
| Monday, July 20 |
| » Defeated Mariners (37-57), 6-4 | Kingdome (3-1) | 44-50 | |
| » W: Walt Terrell (4-8) L: Mark Grant (0-2) S: Kurt Knudsen (4) | Sixth | 13 out |
| Tuesday, July 21 |
| » Defeated Mariners (37-58), 6-2 | Kingdome (4-1) | 45-50 | Won 2 |
| » W: Frank Tanana (9-6) L: Randy Johnson (5-11) | Sixth | 13 out |
| Wednesday, July 22 |
| » Defeated Mariners (37-59), 3-2 | Kingdome (5-1) | 46-50 | Won 3 |
| » W: Bill Gullickson (11-6) L: Erik Hanson (8-12) S: Kurt Knudsen (5) | Fifth | 12 out |
| Thursday, July 23 |
| » Defeated Angels (40-55), 5-2 | Anaheim Stadium (2-1) | 47-50 | Won 4 |
| » W: Mark Leiter (7-4) L: Mark Langston (9-8) S: John Doherty (3) | Fourth | 12 out |
| Friday, July 24 |
| » Lost to Angels (41-55), 6-3 | Anaheim Stadium (2-2) | 47-51 | |
| » W: Bert Blyleven (4-4) L: Kevin Ritz (2-5) S: Joe Grahe (7) | Fifth | 12 out |
| Saturday, July 25 |
| » Lost to Angels (42-55), 9-0 | Anaheim Stadium (2-3) | 47-52 | Lost 2 |
| » W: Tim Fortugno (1-0) L: Walt Terrell (4-9) | Fifth | 12 out |
| Sunday, July 26 |
| » Lost to Angels (43-55), 4-3 | Anaheim Stadium (2-4) | 47-53 | Lost 3 |
| » W: Chuck Crim (5-3) L: John Doherty (2-2) S: Joe Grahe (8) | Fifth | 12 out |
| Tuesday, July 28 |
| » Lost to White Sox (48-50), 8-6 | Tiger Stadium (23-28) | 47-54 | Lost 4 |
| » W: Jack McDowell (14-5) L: Bill Gullickson (11-7) S: Scott Radinsky (7) | Sixth | 13½ out |
| » Lost to White Sox (49-50), 5-3 | Tiger Stadium (23-29) | 47-55 | Lost 5 |
| » W: Alex Fernandez (4-7) L: Buddy Groom (0-4) S: Bobby Thigpen (20) | Sixth | 13½ out |
| Wednesday, July 29 |
| » Lost to White Sox (50-50), 8-6 | Tiger Stadium (23-30) | 47-56 | Lost 6 |
| » W: Terry Leach (3-4) L: Mike Munoz (1-2) S: Scott Radinsky (8) | Sixth | 13½ out |
| Friday, July 31 |
| » Defeated Indians (44-59), 9-6 | Cleveland Stadium (4-1) | 48-56 | |
| » W: John Kiely (3-0) L: Eric Plunk (1-2) S: Mike Henneman (17) | Sixth | 14 out |
| Saturday, August 1 |
| » Lost to Indians (45-59), 8-5 | Cleveland Stadium (4-2) | 48-57 | |
| » W: Eric Plunk (2-2) L: Les Lancaster (3-3) S: Derek Lilliquist (4) | Sixth | 15 out |
| Sunday, August 2 |
| » Defeated Indians (45-60), 5-4 | Cleveland Stadium (5-2) | 49-57 | |
| » W: Bill Gullickson (12-7) L: Charles Nagy (11-7) S: Mike Henneman (18) | Sixth | 15 out |
| Monday, August 3 |
| » Lost to Orioles (60-46), 6-3 | Oriole Park at Camden Yards (0-5) | 49-58 | |
| » W: Arthur Rhodes (4-0) L: Buddy Groom (0-5) S: Storm Davis (4) | Fifth | 15 out |
| Tuesday, August 4 |
| » Lost to Orioles (61-46), 6-3 | Oriole Park at Camden Yards (0-6) | 49-59 | Lost 2 |
| » W: Rick Sutcliffe (11-11) L: Kurt Knudsen (2-1) S: Gregg Olson (26) | Sixth | 15 out |
| Wednesday, August 5 |
| » Lost to Orioles (62-46), 4-0 | Oriole Park at Camden Yards (0-7) | 49-60 | Lost 3 |
| » W: Mike Mussina (11-4) L: John Kiely (3-1) | Sixth | 16 out |
| Thursday, August 6 |
| » Lost to Blue Jays (65-43), 15-11 | Tiger Stadium (23-31) | 49-61 | Lost 4 |
| » W: Jack Morris (14-4) L: Frank Tanana (9-7) | Sixth | 17 out |
| Friday, August 7 |
| » Defeated Blue Jays (65-44), 7-2 | Tiger Stadium (24-31) | 50-61 | |
| » W: Bill Gullickson (13-7) L: Jimmy Key (7-9) | Sixth | 16 out |
| Saturday, August 8 |
| » Defeated Blue Jays (65-45), 8-6 | Tiger Stadium (25-31) | 51-61 | Won 2 |
| » W: John Kiely (4-1) L: Doug Linton (0-1) S: Mike Henneman (19) | Sixth | 15 out |
| » Major-league debuts: Rico Brogna (Tigers) |
| Sunday, August 9 |
| » Defeated Blue Jays (65-46), 9-2 | Tiger Stadium (26-31) | 52-61 | Won 3 |
| » W: Dave Haas (1-0) L: David Wells (6-6) | Fifth | 14 out |
| Monday, August 10 |
| » Defeated Yankees (51-61), 10-5 | Tiger Stadium (27-31) | 53-61 | Won 4 |
| » W: John Doherty (3-2) L: Shawn Hillegas (1-6) | Fifth | 14 out |
| Tuesday, August 11 |
| » Defeated Yankees (51-62), 5-1 | Tiger Stadium (28-31) | 54-61 | Won 5 |
| » W: Frank Tanana (10-7) L: Melido Perez (9-12) | Fourth | 13 out |
| Wednesday, August 12 |
| » Lost to Yankees (52-62), 10-0 | Tiger Stadium (28-32) | 54-62 | |
| » W: Scott Sanderson (10-8) L: Bill Gullickson (13-8) | Fourth | 13 out |
| Friday, August 14 |
| » Defeated Rangers (59-60), 9-6 | Arlington Stadium (4-0) | 55-62 | |
| » W: Dave Haas (2-0) L: Roger Pavlik (0-1) S: Mike Henneman (20) | Fourth | 13½ out |
| Saturday, August 15 |
| » Defeated Rangers (59-61), 10-3 | Arlington Stadium (5-0) | 56-62 | Won 2 |
| » W: John Doherty (4-2) L: Bobby Witt (9-11) S: Mike Munoz (1) | Fourth | 13 out |
| Sunday, August 16 |
| » Defeated Rangers (59-62), 6-0 | Arlington Stadium (6-0) | 57-62 | Won 3 |
| » W: Frank Tanana (11-7) L: Nolan Ryan (5-6) | Fourth | 12½ out |
| Monday, August 17 |
| » Lost to Royals (54-64), 6-5 | Royals Stadium (2-2) | 57-63 | |
| » W: Rusty Meacham (7-3) L: Kurt Knudsen (2-2) S: Jeff Montgomery (30) | Fourth | 13 out |
| Tuesday, August 18 |
| » Defeated Royals (54-65), 5-1 | Royals Stadium (3-2) | 58-63 | |
| » W: Eric King (3-4) L: Juan Berenguer (4-3) | Fourth | 13 out |
| Wednesday, August 19 |
| » Lost to Royals (55-65), 7-2 | Royals Stadium (3-3) | 58-64 | |
| » W: Kevin Appier (14-5) L: Dave Haas (2-1) | Fourth | 13 out |
| Friday, August 21 |
| » Lost to Brewers (66-55), 3-2 | County Stadium (1-3) | 58-65 | Lost 2 |
| » W: Jaime Navarro (14-8) L: John Doherty (4-3) S: Doug Henry (24) | Fourth | 12½ out |
| Saturday, August 22 |
| » Lost to Brewers (67-55), 5-1 | County Stadium (1-4) | 58-66 | Lost 3 |
| » W: Cal Eldred (4-1) L: Frank Tanana (11-8) | Fifth | 13½ out |
| Sunday, August 23 |
| » Defeated Brewers (67-56), 3-2 | County Stadium (2-4) | 59-66 | |
| » W: Mike Henneman (1-5) L: Dan Plesac (4-4) | Fourth | 12½ out |
| Monday, August 24 |
| » Defeated Twins (69-56), 6-2 | Hubert H. Humphrey Metrodome (1-3) | 60-66 | Won 2 |
| » W: Eric King (4-4) L: Bill Krueger (10-5) | Fourth | 11½ out |
| Tuesday, August 25 |
| » Defeated Twins (69-57), 4-3 | Hubert H. Humphrey Metrodome (2-3) | 61-66 | Won 3 |
| » W: Dave Haas (3-1) L: Kevin Tapani (13-9) S: Mike Henneman (21) | Fourth | 10½ out |
| Wednesday, August 26 |
| » Lost to Twins (70-57), 1-0 | Hubert H. Humphrey Metrodome (2-4) | 61-67 | |
| » W: John Smiley (14-6) L: John Kiely (4-2) | Fourth | 11½ out |
| Friday, August 28 |
| » Defeated Royals (57-70), 4-2 | Tiger Stadium (29-32) | 62-67 | |
| » W: Walt Terrell (5-9) L: Rusty Meacham (8-4) S: Mike Henneman (22) | Fourth | 11 out |
| Saturday, August 29 |
| » Defeated Royals (57-71), 12-1 | Tiger Stadium (30-32) | 63-67 | Won 2 |
| » W: Bill Gullickson (14-8) L: Juan Berenguer (4-4) | Fourth | 10 out |
| Sunday, August 30 |
| » Lost to Royals (58-71), 9-4 | Tiger Stadium (30-33) | 63-68 | |
| » W: Kevin Appier (15-6) L: Eric King (4-5) | Fourth | 11 out |
| Monday, August 31 |
| » Lost to Twins (73-59), 5-3 | Tiger Stadium (30-34) | 63-69 | Lost 2 |
| » W: Gary Wayne (2-2) L: Mike Henneman (1-6) S: Rick Aguilera (34) | Fourth | 12 out |
| Tuesday, September 1 |
| » Lost to Twins (74-59), 5-4 | Tiger Stadium (30-35) | 63-70 | Lost 3 |
| » W: Carl Willis (6-3) L: Les Lancaster (3-4) S: Rick Aguilera (35) | Fourth | 13 out |
| Wednesday, September 2 |
| » Lost to Twins (75-59), 4-2 | Tiger Stadium (30-36) | 63-71 | Lost 4 |
| » W: Scott Erickson (10-10) L: Walt Terrell (5-10) S: Rick Aguilera (36) | Fourth | 13 out |
| Friday, September 4 |
| » Lost to Brewers (72-62), 6-3 | Tiger Stadium (30-37) | 63-72 | Lost 5 |
| » W: Chris Bosio (13-5) L: Bill Gullickson (14-9) S: Dan Plesac (1) | Fourth | 14 out |
| Saturday, September 5 |
| » Lost to Brewers (73-62), 10-3 | Tiger Stadium (30-38) | 63-73 | Lost 6 |
| » W: Bill Wegman (12-12) L: Dave Haas (3-2) | Fifth | 15 out |
| Sunday, September 6 |
| » Defeated Brewers (73-63), 6-2 | Tiger Stadium (31-38) | 64-73 | |
| » W: John Doherty (5-3) L: Jaime Navarro (14-11) | Fourth | 15 out |
| Tuesday, September 8 |
| » Lost to White Sox (73-63), 4-3 | Comiskey Park II (1-3) | 64-74 | |
| » W: Jack McDowell (20-7) L: Frank Tanana (11-9) S: Roberto Hernandez (7) | Sixth | 16 out |
| » Lost to White Sox (74-63), 4-3 | Comiskey Park II (1-4) | 64-75 | Lost 2 |
| » W: Terry Leach (4-4) L: Mark Leiter (7-5) S: Scott Radinsky (15) | Sixth | 16 out |
| Wednesday, September 9 |
| » Lost to White Sox (75-63), 6-4 | Comiskey Park II (1-5) | 64-76 | Lost 3 |
| » W: Terry Leach (5-4) L: Bill Gullickson (14-10) S: Roberto Hernandez (8) | Sixth | 17 out |
| Thursday, September 10 |
| » Defeated White Sox (75-64), 8-0 | Comiskey Park II (2-5) | 65-76 | |
| » W: Dave Haas (4-2) L: Alex Fernandez (7-9) | Fifth | 16½ out |
| Friday, September 11 |
| » Lost to Red Sox (65-75), 7-6 | Fenway Park (1-3) | 65-77 | |
| » W: Mike Gardiner (4-10) L: John Doherty (5-4) S: Ken Ryan (1) | Sixth | 17 out |
| Saturday, September 12 |
| » Defeated Red Sox (65-76), 9-5 | Fenway Park (2-3) | 66-77 | |
| » W: Walt Terrell (6-10) L: Roger Clemens (18-9) | Sixth | 17 out |
| Sunday, September 13 |
| » Defeated Red Sox (65-77), 7-2 | Fenway Park (3-3) | 67-77 | Won 2 |
| » W: Frank Tanana (12-9) L: John Dopson (7-8) | Sixth | 17 out |
| Tuesday, September 15 |
| » Lost to Rangers (71-76), 6-5 | Tiger Stadium (31-39) | 67-78 | |
| » W: Jose Guzman (14-11) L: Bill Gullickson (14-11) S: Matt Whiteside (1) | Sixth | 17½ out |
| Wednesday, September 16 |
| » Defeated Rangers (71-77), 4-1 | Tiger Stadium (32-39) | 68-78 | |
| » W: Dave Haas (5-2) L: Roger Pavlik (4-3) S: Mike Henneman (23) | Sixth | 16½ out |
| Friday, September 18 |
| » Defeated Red Sox (66-81), 10-3 | Tiger Stadium (33-39) | 69-78 | Won 2 |
| » W: John Doherty (6-4) L: John Dopson (7-9) S: Eric King (1) | Fourth | 17 out |
| Saturday, September 19 |
| » Defeated Red Sox (66-82), 3-2 | Tiger Stadium (34-39) | 70-78 | Won 3 |
| » W: Frank Tanana (13-9) L |
