| Wednesday, January 15 |
| Former Indian Charlie Gassaway dies in Miami, FL at the age of 74. |
| Saturday, February 8 |
| Former Indian Fabian Gaffke dies in Milwaukee, WI at the age of 79. |
| Wednesday, March 4 |
| Former Indian Larry Rosenthal dies in Woodbury, MN at the age of 82. |
| Monday, April 6 |
| » Lost to Orioles (1-0), 2-0 | Oriole Park at Camden Yards (0-1) | 0-1 | |
| » W: Rick Sutcliffe (1-0) L: Charles Nagy (0-1) | Third | 1 out |
| Wednesday, April 8 |
| » Defeated Orioles (1-1), 4-0 | Oriole Park at Camden Yards (1-1) | 1-1 | |
| » W: Dave Otto (1-0) L: Bob Milacki (0-1) | Third | 1 out |
| Thursday, April 9 |
| » Lost to Orioles (2-1), 2-0 | Oriole Park at Camden Yards (1-2) | 1-2 | |
| » W: Ben McDonald (1-0) L: Jack Armstrong (0-1) | Fourth | 2 out |
| Saturday, April 11 |
| » Lost to Red Sox (1-2), 7-5 | Cleveland Stadium (0-1) | 1-3 | Lost 2 |
| » W: Mike Gardiner (1-0) L: Eric Bell (0-1) | Fifth | 3½ out |
| » Major-league debuts: Peter Hoy (Red Sox) |
| Sunday, April 12 |
| » Defeated Red Sox (1-3), 2-1 | Cleveland Stadium (1-1) | 2-3 | |
| » W: Charles Nagy (1-1) L: Matt Young (0-1) S: Derek Lilliquist (1) | Fourth | 4 out |
| » Lost to Red Sox (2-3), 3-0 | Cleveland Stadium (1-2) | 2-4 | |
| » W: Roger Clemens (1-1) L: Scott Scudder (0-1) | Fourth | 4 out |
| » Major-league debuts: John Flaherty (Red Sox) |
| Monday, April 13 |
| » Lost to Tigers (1-6), 7-5 | Cleveland Stadium (1-3) | 2-5 | Lost 2 |
| » W: Mark Leiter (1-0) L: Rod Nichols (0-1) S: Mike Henneman (1) | Fifth | 4½ out |
| Tuesday, April 14 |
| » Defeated Tigers (1-7), 8-7 | Cleveland Stadium (2-3) | 3-5 | |
| » W: Ted Power (1-0) L: Les Lancaster (0-1) S: Steve Olin (1) | Fourth | 4 out |
| Wednesday, April 15 |
| » Lost to Tigers (2-7), 8-1 | Cleveland Stadium (2-4) | 3-6 | |
| » W: Eric King (1-1) L: Eric Bell (0-2) | Sixth | 5 out |
| Thursday, April 16 |
| » Lost to Tigers (3-7), 13-4 | Cleveland Stadium (2-5) | 3-7 | Lost 2 |
| » W: Bill Gullickson (1-2) L: Dennis Cook (0-1) | Sixth | 6 out |
| Friday, April 17 |
| » Defeated Yankees (6-4), 11-1 | Yankee Stadium (1-0) | 4-7 | |
| » W: Charles Nagy (2-1) L: Scott Sanderson (2-1) | Sixth | 5 out |
| » Major-league debuts: Russ Springer (Yankees) |
| Saturday, April 18 |
| » Lost to Yankees (7-4), 14-0 | Yankee Stadium (1-1) | 4-8 | |
| » W: Greg Cadaret (1-0) L: Dave Otto (1-1) | Fifth | 6 out |
| Sunday, April 19 |
| » Lost to Yankees (8-4), 5-3 | Yankee Stadium (1-2) | 4-9 | Lost 2 |
| » W: Jeff Johnson (1-1) L: Jack Armstrong (0-2) S: Steve Howe (2) | Sixth | 6 out |
| Monday, April 20 |
| » Defeated Yankees (8-5), 3-1 | Yankee Stadium (2-2) | 5-9 | |
| » W: Scott Scudder (1-1) L: Melido Perez (1-2) S: Steve Olin (2) | Fifth | 6 out |
| Tuesday, April 21 |
| » Lost to Blue Jays (12-3), 2-1 | Skydome (0-1) | 5-10 | |
| » W: Jack Morris (3-0) L: Dennis Cook (0-2) | Sixth | 7 out |
| Wednesday, April 22 |
| » Defeated Blue Jays (12-4), 7-2 | Skydome (1-1) | 6-10 | |
| » W: Charles Nagy (3-1) L: Dave Stieb (0-1) S: Ted Power (1) | Sixth | 6 out |
| Thursday, April 23 |
| » Lost to Blue Jays (13-4), 13-8 | Skydome (1-2) | 6-11 | |
| » W: Todd Stottlemyre (2-1) L: Dave Otto (1-2) | Fourth | 7 out |
| Friday, April 24 |
| » Lost to Brewers (7-7), 5-0 | Cleveland Stadium (2-6) | 6-12 | Lost 2 |
| » W: Dan Plesac (2-1) L: Jack Armstrong (0-3) | Fifth | 8 out |
| » Major-league debuts: Jesse Levis (Indians) |
| Sunday, April 26 |
| » Lost to Brewers (8-7), 9-4 | Cleveland Stadium (2-7) | 6-13 | Lost 3 |
| » W: Chris Bosio (1-1) L: Scott Scudder (1-2) | Sixth | 8 out |
| » Defeated Brewers (8-8), 3-1 | Cleveland Stadium (3-7) | 7-13 | |
| » W: Dennis Cook (1-2) L: Jaime Navarro (1-2) S: Ted Power (2) | Sixth | 8 out |
| Tuesday, April 28 |
| » Lost to Athletics (13-7), 3-1 | Cleveland Stadium (3-8) | 7-14 | |
| » W: Mike Moore (4-0) L: Steve Olin (0-1) S: Dennis Eckersley (7) | Sixth | 8 out |
| Wednesday, April 29 |
| » Defeated Athletics (13-8), 5-2 | Cleveland Stadium (4-8) | 8-14 | |
| » W: Dave Otto (2-2) L: Ron Darling (1-1) S: Steve Olin (3) | Fourth | 8 out |
| Thursday, April 30 |
| » Lost to Angels (11-10), 8-5 | Cleveland Stadium (4-9) | 8-15 | |
| » W: Joe Grahe (2-2) L: Jeff Shaw (0-1) S: Bryan Harvey (6) | Fifth | 8 out |
| Friday, May 1 |
| » Lost to Angels (12-10), 7-5 | Cleveland Stadium (4-10) | 8-16 | Lost 2 |
| » W: Mark Langston (2-1) L: Scott Scudder (1-3) S: Bryan Harvey (7) | Fifth | 8 out |
| Saturday, May 2 |
| » Defeated Angels (12-11), 3-2 | Cleveland Stadium (5-10) | 9-16 | |
| » W: Derek Lilliquist (1-0) L: Mark Eichhorn (0-1) S: Steve Olin (4) | Sixth | 7 out |
| Sunday, May 3 |
| » Lost to Angels (13-11), 6-3 | Cleveland Stadium (5-11) | 9-17 | |
| » W: Scott Bailes (2-0) L: Derek Lilliquist (1-1) S: Bryan Harvey (8) | Seventh | 8 out |
| Monday, May 4 |
| » Lost to Royals (5-19), 11-6 | Cleveland Stadium (5-12) | 9-18 | Lost 2 |
| » W: Rusty Meacham (1-0) L: Rod Nichols (0-2) | Seventh | 9 out |
| Tuesday, May 5 |
| » Defeated Royals (5-20), 8-6 | Cleveland Stadium (6-12) | 10-18 | |
| » W: Jack Armstrong (1-3) L: Mike Magnante (0-2) S: Steve Olin (5) | Seventh | 9 out |
| Wednesday, May 6 |
| » Defeated Rangers (16-14), 7-2 | Arlington Stadium (1-0) | 11-18 | Won 2 |
| » W: Scott Scudder (2-3) L: Bobby Witt (3-3) S: Kevin Wickander (1) | Seventh | 9 out |
| Thursday, May 7 |
| » Defeated Rangers (16-15), 8-7 | Arlington Stadium (2-0) | 12-18 | Won 3 |
| » W: Rod Nichols (1-2) L: Mike Campbell (0-1) S: Steve Olin (6) | Sixth | 9 out |
| Friday, May 8 |
| » Lost to Twins (13-16), 7-4 | Hubert H. Humphrey Metrodome (0-1) | 12-19 | |
| » W: Scott Erickson (2-3) L: Charles Nagy (3-2) S: Rick Aguilera (8) | Seventh | 9 out |
| Saturday, May 9 |
| » Lost to Twins (14-16), 10-5 | Hubert H. Humphrey Metrodome (0-2) | 12-20 | Lost 2 |
| » W: John Smiley (2-2) L: Dave Otto (2-3) | Seventh | 9 out |
| Sunday, May 10 |
| » Lost to Twins (15-16), 10-6 | Hubert H. Humphrey Metrodome (0-3) | 12-21 | Lost 3 |
| » W: Mark Guthrie (1-0) L: Jack Armstrong (1-4) S: Rick Aguilera (9) | Seventh | 10 out |
| Tuesday, May 12 |
| » Lost to Royals (9-22), 3-0 | Royals Stadium (0-1) | 12-22 | Lost 4 |
| » W: Mark Gubicza (3-2) L: Scott Scudder (2-4) | Seventh | 11 out |
| Wednesday, May 13 |
| » Lost to Royals (10-22), 5-3 | Royals Stadium (0-2) | 12-23 | Lost 5 |
| » W: Kevin Appier (3-2) L: Dennis Cook (1-3) S: Jeff Montgomery (7) | Seventh | 12 out |
| Friday, May 15 |
| » Defeated Twins (17-17), 5-0 | Cleveland Stadium (7-12) | 13-23 | |
| » W: Charles Nagy (4-2) L: Scott Erickson (2-4) | Seventh | 11½ out |
| Saturday, May 16 |
| » Lost to Twins (18-17), 8-6 | Cleveland Stadium (7-13) | 13-24 | |
| » W: John Smiley (3-2) L: Jack Armstrong (1-5) S: Rick Aguilera (11) | Seventh | 12 out |
| Sunday, May 17 |
| » Lost to Twins (19-17), 9-5 | Cleveland Stadium (7-14) | 13-25 | Lost 2 |
| » W: Kevin Tapani (3-4) L: Dennis Cook (1-4) S: Rick Aguilera (12) | Seventh | 12 out |
| Monday, May 18 |
| » Lost to Rangers (20-20), 3-2 | Cleveland Stadium (7-15) | 13-26 | Lost 3 |
| » W: Kevin Brown (6-3) L: Derek Lilliquist (1-2) S: Kenny Rogers (3) | Seventh | 12 out |
| Tuesday, May 19 |
| » Lost to Rangers (21-20), 8-7 | Cleveland Stadium (7-16) | 13-27 | Lost 4 |
| » W: Lance McCullers (1-0) L: Steve Olin (0-2) S: Jeff Russell (11) | Seventh | 12 out |
| Wednesday, May 20 |
| » Lost to Rangers (22-20), 1-0 | Cleveland Stadium (7-17) | 13-28 | Lost 5 |
| » W: Jose Guzman (3-3) L: Charles Nagy (4-3) S: Jeff Russell (12) | Seventh | 12½ out |
| Friday, May 22 |
| » Lost to Mariners (16-25), 2-1 | Kingdome (0-1) | 13-29 | Lost 6 |
| » W: Randy Johnson (5-3) L: Scott Scudder (2-5) S: Mike Schooler (9) | Seventh | 13½ out |
| Saturday, May 23 |
| » Defeated Mariners (16-26), 5-4 | Kingdome (1-1) | 14-29 | |
| » W: Derek Lilliquist (2-2) L: Erik Hanson (1-7) S: Steve Olin (7) | Seventh | 12½ out |
| Sunday, May 24 |
| » Lost to Mariners (17-26), 5-4 | Kingdome (1-2) | 14-30 | |
| » W: Calvin Jones (2-1) L: Steve Olin (0-3) | Seventh | 13 out |
| Monday, May 25 |
| » Defeated Athletics (26-18), 10-6 | Oakland-Alameda County Stadium (1-0) | 15-30 | |
| » W: Charles Nagy (5-3) L: Joe Slusarski (4-2) S: Ted Power (3) | Seventh | 12 out |
| Tuesday, May 26 |
| » Defeated Athletics (26-19), 1-0 | Oakland-Alameda County Stadium (2-0) | 16-30 | Won 2 |
| » W: Dave Otto (3-3) L: Bob Welch (2-3) S: Steve Olin (8) | Seventh | 12 out |
| Wednesday, May 27 |
| » Defeated Athletics (26-20), 4-2 | Oakland-Alameda County Stadium (3-0) | 17-30 | Won 3 |
| » W: Scott Scudder (3-5) L: Dave Stewart (3-5) S: Steve Olin (9) | Seventh | 11 out |
| Friday, May 29 |
| » Defeated Angels (20-26), 14-2 | Anaheim Stadium (1-0) | 18-30 | Won 4 |
| » W: Denis Boucher (1-0) L: Chuck Finley (1-4) | Seventh | 11 out |
| Saturday, May 30 |
| » Lost to Angels (21-26), 3-1 | Anaheim Stadium (1-1) | 18-31 | |
| » W: Bert Blyleven (1-0) L: Jack Armstrong (1-6) S: Bryan Harvey (13) | Seventh | 12 out |
| Sunday, May 31 |
| » Defeated Angels (21-27), 4-3 | Anaheim Stadium (2-1) | 19-31 | |
| » W: Charles Nagy (6-3) L: Jim Abbott (2-7) S: Steve Olin (10) | Seventh | 12 out |
| Tuesday, June 2 |
| » Defeated Mariners (21-29), 4-3 | Cleveland Stadium (8-17) | 20-31 | Won 2 |
| » W: Dave Otto (4-3) L: Erik Hanson (2-8) S: Steve Olin (11) | Seventh | 12½ out |
| Wednesday, June 3 |
| » Defeated Mariners (21-30), 8-3 | Cleveland Stadium (9-17) | 21-31 | Won 3 |
| » W: Scott Scudder (4-5) L: Clay Parker (0-1) | Seventh | 11½ out |
| Thursday, June 4 |
| » Lost to Mariners (22-30), 10-3 | Cleveland Stadium (9-18) | 21-32 | |
| » W: Dave Fleming (8-1) L: Denis Boucher (1-1) | Seventh | 12 out |
| Saturday, June 6 |
| » Lost to Red Sox (25-24), 5-1 | Fenway Park (0-1) | 21-33 | Lost 2 |
| » W: Roger Clemens (9-3) L: Jack Armstrong (1-7) | Seventh | 12 out |
| » Defeated Red Sox (25-25), 3-1 | Fenway Park (1-1) | 22-33 | |
| » W: Charles Nagy (7-3) L: Frank Viola (5-4) S: Steve Olin (12) | Seventh | 12 out |
| Sunday, June 7 |
| » Lost to Red Sox (26-25), 4-0 | Fenway Park (1-2) | 22-34 | |
| » W: Joe Hesketh (2-3) L: Dave Otto (4-4) S: Danny Darwin (3) | Seventh | 12 out |
| Monday, June 8 |
| » Lost to Tigers (25-31), 9-2 | Tiger Stadium (0-1) | 22-35 | Lost 2 |
| » W: Mark Leiter (4-3) L: Scott Scudder (4-6) S: Kurt Knudsen (1) | Seventh | 13 out |
| Tuesday, June 9 |
| » Defeated Tigers (25-32), 6-1 | Tiger Stadium (1-1) | 23-35 | |
| » W: Denis Boucher (2-1) L: Frank Tanana (4-5) | Seventh | 13 out |
| Wednesday, June 10 |
| » Defeated Tigers (25-33), 4-2 | Tiger Stadium (2-1) | 24-35 | Won 2 |
| » W: Steve Olin (1-3) L: Mike Munoz (0-1) | Seventh | 13 out |
| Friday, June 12 |
| » Defeated Yankees (28-30), 3-0 | Cleveland Stadium (10-18) | 25-35 | Won 3 |
| » W: Charles Nagy (8-3) L: Scott Kamieniecki (1-4) | Sixth | 12½ out |
| Saturday, June 13 |
| » Lost to Yankees (29-30), 4-1 | Cleveland Stadium (10-19) | 25-36 | |
| » W: Melido Perez (6-4) L: Dave Otto (4-5) S: Steve Farr (8) | Seventh | 12½ out |
| Sunday, June 14 |
| » Lost to Yankees (30-30), 4-3 | Cleveland Stadium (10-20) | 25-37 | Lost 2 |
| » W: Rich Monteleone (4-1) L: Ted Power (1-1) S: Steve Farr (9) | Seventh | 13½ out |
| Monday, June 15 |
| » Lost to Orioles (38-24), 6-5 | Cleveland Stadium (10-21) | 25-38 | Lost 3 |
| » W: Storm Davis (3-2) L: Dennis Cook (1-5) S: Gregg Olson (18) | Seventh | 14 out |
| Tuesday, June 16 |
| » Defeated Orioles (38-25), 7-5 | Cleveland Stadium (11-21) | 26-38 | |
| » W: Jack Armstrong (2-7) L: Ben McDonald (7-4) S: Steve Olin (13) | Seventh | 13 out |
| Wednesday, June 17 |
| » Defeated Orioles (38-26), 3-2 | Cleveland Stadium (12-21) | 27-38 | Won 2 |
| » W: Charles Nagy (9-3) L: Mike Mussina (8-2) | Seventh | 13 out |
| Thursday, June 18 |
| » Lost to Brewers (34-29), 4-1 | County Stadium (0-1) | 27-39 | |
| » W: Bill Wegman (7-5) L: Dave Otto (4-6) | Seventh | 13 out |
| Friday, June 19 |
| » Defeated Brewers (34-30), 5-3 | County Stadium (1-1) | 28-39 | |
| » W: Scott Scudder (5-6) L: Ricky Bones (3-3) S: Steve Olin (14) | Seventh | 12 out |
| Saturday, June 20 |
| » Lost to Brewers (35-30), 4-1 | County Stadium (1-2) | 28-40 | |
| » W: Chris Bosio (5-4) L: Denis Boucher (2-2) S: Doug Henry (11) | Seventh | 13 out |
| Sunday, June 21 |
| » Lost to Brewers (36-30), 4-2 | County Stadium (1-3) | 28-41 | Lost 2 |
| » W: Dan Plesac (3-2) L: Jack Armstrong (2-8) S: Doug Henry (12) | Seventh | 13 out |
| Monday, June 22 |
| » Lost to White Sox (32-35), 7-1 | Comiskey Park II (0-1) | 28-42 | Lost 3 |
| » W: Charlie Hough (3-4) L: Charles Nagy (9-4) | Seventh | 14 out |
| Tuesday, June 23 |
| » Lost to White Sox (33-35), 7-1 | Comiskey Park II (0-2) | 28-43 | Lost 4 |
| » W: Jack McDowell (10-3) L: Dave Otto (4-7) | Seventh | 14½ out |
| Wednesday, June 24 |
| » Lost to White Sox (34-35), 4-3 | Comiskey Park II (0-3) | 28-44 | Lost 5 |
| » W: Roberto Hernandez (2-0) L: Ted Power (1-2) | Seventh | 15½ out |
| Friday, June 26 |
| » Lost to Blue Jays (44-28), 6-1 | Cleveland Stadium (12-22) | 28-45 | Lost 6 |
| » W: Juan Guzman (10-1) L: Jack Armstrong (2-9) | Seventh | 16½ out |
| Saturday, June 27 |
| » Defeated Blue Jays (44-29), 6-4 | Cleveland Stadium (13-22) | 29-45 | |
| » W: Eric Plunk (1-0) L: Duane Ward (3-3) | Seventh | 15½ out |
| Sunday, June 28 |
| » Defeated Blue Jays (44-30), 7-6 | Cleveland Stadium (14-22) | 30-45 | Won 2 |
| » W: Steve Olin (2-3) L: Duane Ward (3-4) S: Eric Plunk (1) | Seventh | 14½ out |
| Monday, June 29 |
| » Lost to White Sox (37-36), 9-6 | Cleveland Stadium (14-23) | 30-46 | |
| » W: Jack McDowell (11-3) L: Scott Scudder (5-7) S: Bobby Thigpen (18) | Seventh | 15½ out |
| Tuesday, June 30 |
| » Defeated White Sox (37-37), 5-4 | Cleveland Stadium (15-23) | 31-46 | |
| » W: Derek Lilliquist (3-2) L: Terry Leach (1-2) | Seventh | 14½ out |
| Wednesday, July 1 |
| » Lost to White Sox (38-37), 8-5 | Cleveland Stadium (15-24) | 31-47 | |
| » W: Kirk McCaskill (6-6) L: Jack Armstrong (2-10) S: Bobby Thigpen (19) | Seventh | 15½ out |
| Friday, July 3 |
| » Defeated Athletics (46-32), 8-1 | Cleveland Stadium (16-24) | 32-47 | |
| » W: Charles Nagy (10-4) L: Ron Darling (7-6) | Seventh | 15½ out |
| Saturday, July 4 |
| » Defeated Athletics (46-33), 8-1 | Cleveland Stadium (17-24) | 33-47 | Won 2 |
| » W: Scott Scudder (6-7) L: Kelly Downs (1-3) S: Ted Power (4) | Seventh | 15½ out |
| Sunday, July 5 |
| » Lost to Athletics (47-33), 5-2 | Cleveland Stadium (17-25) | 33-48 | |
| » W: Bob Welch (6-4) L: Jack Armstrong (2-11) S: Dennis Eckersley (29) | Seventh | 16½ out |
| Monday, July 6 |
| » Lost to Athletics (48-33), 13-4 | Cleveland Stadium (17-26) | 33-49 | Lost 2 |
| » W: Mike Moore (9-7) L: Jeff Mutis (0-1) | Seventh | 17½ out |
| Tuesday, July 7 |
| » Defeated Angels (32-50), 3-1 | Cleveland Stadium (18-26) | 34-49 | |
| » W: Dennis Cook (2-5) L: Chuck Finley (2-9) S: Steve Olin (15) | Seventh | 17½ out |
| Wednesday, July 8 |
| » Defeated Angels (32-51), 8-4 | Cleveland Stadium (19-26) | 35-49 | Won 2 |
| » W: Charles Nagy (11-4) L: Mark Langston (8-7) | Seventh | 17½ out |
| Thursday, July 9 |
| » Lost to Rangers (46-41), 14-4 | Arlington Stadium (2-1) | 35-50 | |
| » W: Nolan Ryan (3-3) L: Scott Scudder (6-8) | Seventh | 18½ out |
| » Major-league debuts: Jeff Frye (Rangers) |
| Friday, July 10 |
| » Lost to Rangers (47-41), 6-5 | Arlington Stadium (2-2) | 35-51 | Lost 2 |
| » W: Brian Bohanon (1-0) L: Jack Armstrong (2-12) S: Jeff Russell (21) | Seventh | 18½ out |
| Saturday, July 11 |
| » Lost to Rangers (48-41), 5-1 | Arlington Stadium (2-3) | 35-52 | Lost 3 |
| » W: Kevin Brown (14-4) L: Jeff Mutis (0-2) | Seventh | 18½ out |
| Sunday, July 12 |
| » Defeated Rangers (48-42), 6-3 | Arlington Stadium (3-3) | 36-52 | |
| » W: Steve Olin (3-3) L: Kenny Rogers (1-4) S: Eric Plunk (2) | Seventh | 17½ out |
| Thursday, July 16 |
| » Lost to Royals (38-50), 3-2 | Royals Stadium (0-3) | 36-53 | |
| » W: Hipolito Pichardo (4-4) L: Jose Mesa (3-9) S: Jeff Montgomery (22) | Seventh | 18½ out |
| Friday, July 17 |
| » Lost to Royals (39-50), 4-3 | Royals Stadium (0-4) | 36-54 | Lost 2 |
| » W: Jeff Montgomery (1-5) L: Eric Plunk (1-1) | Seventh | 18½ out |
| Saturday, July 18 |
| » Lost to Royals (40-50), 4-1 | Royals Stadium (0-5) | 36-55 | Lost 3 |
| » W: Kevin Appier (11-3) L: Jack Armstrong (2-13) S: Rusty Meacham (2) | Seventh | 19½ out |
| Sunday, July 19 |
| » Defeated Royals (40-51), 4-3 | Royals Stadium (1-5) | 37-55 | |
| » W: Derek Lilliquist (4-2) L: Steve Shifflett (1-1) S: Steve Olin (16) | Seventh | 19½ out |
| Monday, July 20 |
| » Defeated Twins (56-36), 5-1 | Hubert H. Humphrey Metrodome (1-3) | 38-55 | Won 2 |
| » W: Dennis Cook (3-5) L: Willie Banks (3-3) S: Steve Olin (17) | Seventh | 18½ out |
| Tuesday, July 21 |
| » Defeated Twins (56-37), 5-2 | Hubert H. Humphrey Metrodome (2-3) | 39-55 | Won 3 |
| » W: Jose Mesa (4-9) L: Kevin Tapani (10-6) S: Steve Olin (18) | Seventh | 18½ out |
| Wednesday, July 22 |
| » Lost to Twins (57-37), 2-1 | Hubert H. Humphrey Metrodome (2-4) | 39-56 | |
| » W: John Smiley (10-4) L: Charles Nagy (11-5) | Seventh | 18½ out |
| Thursday, July 23 |
| » Defeated Royals (42-53), 1-0 | Cleveland Stadium (20-26) | 40-56 | |
| » W: Kevin Wickander (1-0) L: Mike Magnante (3-7) | Seventh | 18½ out |
| Friday, July 24 |
| » Lost to Royals (43-53), 8-3 | Cleveland Stadium (20-27) | 40-57 | |
| » W: Luis Aquino (1-1) L: Scott Scudder (6-9) S: Jeff Montgomery (24) | Seventh | 18½ out |
| Saturday, July 25 |
| » Defeated Royals (43-54), 6-5 | Cleveland Stadium (21-27) | 41-57 | |
| » W: Steve Olin (4-3) L: Rusty Meacham (4-3) | Seventh | 17½ out |
| Sunday, July 26 |
| » Defeated Royals (43-55), 2-1 | Cleveland Stadium (22-27) | 42-57 | Won 2 |
| » W: Steve Olin (5-3) L: Steve Shifflett (1-3) | Seventh | 16½ out |
| Monday, July 27 |
| » Lost to Brewers (54-44), 4-0 | Cleveland Stadium (22-28) | 42-58 | |
| » W: Jaime Navarro (11-6) L: Charles Nagy (11-6) | Sixth | 17 out |
| Tuesday, July 28 |
| » Defeated Brewers (54-45), 4-2 | Cleveland Stadium (23-28) | 43-58 | |
| » W: Rod Nichols (2-2) L: Ricky Bones (6-7) S: Derek Lilliquist (2) | Seventh | 17 out |
| Wednesday, July 29 |
| » Defeated Brewers (54-46), 4-3 | Cleveland Stadium (24-28) | 44-58 | Won 2 |
| » W: Jack Armstrong (3-13) L: Cal Eldred (1-1) S: Derek Lilliquist (3) | Seventh | 16 out |
| Friday, July 31 |
| » Lost to Tigers (48-56), 9-6 | Cleveland Stadium (24-29) | 44-59 | |
| » W: John Kiely (3-0) L: Eric Plunk (1-2) S: Mike Henneman (17) | Seventh | 17½ out |
| Saturday, August 1 |
| » Defeated Tigers (48-57), 8-5 | Cleveland Stadium (25-29) | 45-59 | |
| » W: Eric Plunk (2-2) L: Les Lancaster (3-3) S: Derek Lilliquist (4) | Seventh | 17½ out |
| Sunday, August 2 |
| » Lost to Tigers (49-57), 5-4 | Cleveland Stadium (25-30) | 45-60 | |
| » W: Bill Gullickson (12-7) L: Charles Nagy (11-7) S: Mike Henneman (18) | Seventh | 18½ out |
| Monday, August 3 |
| » Defeated Yankees (48-57), 8-6 | Yankee Stadium (3-2) | 46-60 | |
| » W: Steve Olin (6-3) L: John Habyan (3-6) | Seventh | 17½ out |
| Tuesday, August 4 |
| » Lost to Yankees (49-57), 4-3 | Yankee Stadium (3-3) | 46-61 | |
| » W: Curt Young (4-2) L: Dave Otto (4-8) S: Steve Farr (14) | Seventh | 17½ out |
| Wednesday, August 5 |
| » Defeated Yankees (49-58), 4-3 | Yankee Stadium (4-3) | 47-61 | |
| » W: Derek Lilliquist (5-2) L: Tim Burke (3-4) | Seventh | 17½ out |
| Friday, August 7 |
| » Defeated Orioles (62-47), 5-4 | Oriole Park at Camden Yards (2-2) | 48-61 | Won 2 |
| » W: Kevin Wickander (2-0) L: Alan Mills (7-2) | Seventh | 17 out |
| Saturday, August 8 |
| » Defeated Orioles (62-48), 6-0 | Oriole Park at Camden Yards (3-2) | 49-61 | Won 3 |
| » W: Charles Nagy (12-7) L: Arthur Rhodes (4-1) | Seventh | 16 out |
| Sunday, August 9 |
| » Lost to Orioles (63-48), 3-2 | Oriole Park at Camden Yards (3-3) | 49-62 | |
| » W: Storm Davis (4-2) L: Ted Power (1-3) | Seventh | 16 out |
| Monday, August 10 |
| » Defeated Red Sox (52-59), 8-5 | Cleveland Stadium (26-30) | 50-62 | |
| » W: Jack Armstrong (4-13) L: Paul Quantrill (1-2) S: Steve Olin (19) | Seventh | 16 out |
| Tuesday, August 11 |
| » Defeated Red Sox (52-60), 3-1 | Cleveland Stadium (27-30) | 51-62 | Won 2 |
| » W: Dave Otto (5-8) L: Frank Viola (10-8) S: Derek Lilliquist (5) | Sixth | 15 out |
| Wednesday, August 12 |
| » Defeated Red Sox (52-61), 8-5 | Cleveland Stadium (28-30) | 52-62 | Won 3 |
| » W: Eric Plunk (3-2) L: Daryl Irvine (2-2) S: Steve Olin (20) | Sixth | 14 out |
| Thursday, August 13 |
| » Lost to Red Sox (53-61), 4-2 | Cleveland Stadium (28-31) | 52-63 | |
| » W: Roger Clemens (14-7) L: Charles Nagy (12-8) S: Jeff Reardon (25) | Seventh | 15 out |
| Friday, August 14 |
| » Lost to Blue Jays (68-48), 9-5 | Cleveland Stadium (28-32) | 52-64 | Lost 2 |
| » W: David Wells (7-6) L: Rod Nichols (2-3) | Seventh | 16 out |
| Sunday, August 16 |
| » Defeated Blue Jays (68-49), 4-2 | Cleveland Stadium (29-32) | 53-64 | |
| » W: Dennis Cook (4-5) L: Todd Stottlemyre (7-8) S: Steve Olin (21) | Seventh | 16 out |
| » Lost to Blue Jays (69-49), 6-2 | Cleveland Stadium (29-33) | 53-65 | |
| » W: Jack Morris (15-5) L: Dave Otto (5-9) | Seventh | 16 out |
| Tuesday, August 18 |
| » Defeated Twins (67-52), 8-1 | Cleveland Stadium (30-33) | 54-65 | |
| » W: Jose Mesa (5-9) L: Scott Erickson (8-10) S: Ted Power (5) | Sixth | 16 out |
| Wednesday, August 19 |
| » Defeated Twins (67-53), 5-1 | Cleveland Stadium (31-33) | 55-65 | Won 2 |
| » W: Charles Nagy (13-8) L: Bill Krueger (10-4) | Fifth | 15 out |
| » Major-league debuts: Mike Trombley (Twins) |
| Thursday, August 20 |
| » Defeated Twins (67-54), 2-1 | Cleveland Stadium (32-33) | 56-65 | Won 3 |
| » W: Eric Plunk (4-2) L: Kevin Tapani (13-8) | Fifth | 14 out |
| Friday, August 21 |
| » Defeated Rangers (60-65), 8-6 | Cleveland Stadium (33-33) | 57-65 | Won 4 |
| » W: Dennis Cook (5-5) L: Nolan Ryan (5-7) S: Steve Olin (22) | Fifth | 13 out |
| Saturday, August 22 |
| » Defeated Rangers (60-66), 6-1 | Cleveland Stadium (34-33) | 58-65 | Won 5 |
| » W: Jack Armstrong (5-13) L: Bobby Witt (9-12) | Fourth | 13 out |
| Sunday, August 23 |
| » Lost to Rangers (61-66), 14-4 | Cleveland Stadium (34-34) | 58-66 | |
| » W: Kenny Rogers (2-5) L: Steve Olin (6-4) | Fifth | 13 out |
| Tuesday, August 25 |
| » Lost to Mariners (52-74), 6-0 | Kingdome (1-3) | 58-67 | Lost 2 |
| » W: Dave Fleming (15-5) L: Charles Nagy (13-9) | Fifth | 12½ out |
| Wednesday, August 26 |
| » Defeated Mariners (52-75), 6-3 | Kingdome (2-3) | 59-67 | |
| » W: Eric Plunk (5-2) L: Russ Swan (3-9) S: Steve Olin (23) | Fifth | 12½ out |
| Thursday, August 27 |
| » Lost to Mariners (53-75), 6-2 | Kingdome (2-4) | 59-68 | |
| » W: Brian Fisher (2-1) L: Dennis Cook (5-6) | Sixth | 13½ out |
| Friday, August 28 |
| » Lost to Athletics (77-51), 7-6 | Oakland-Alameda County Stadium (3-1) | 59-69 | Lost 2 |
| » W: Jim Corsi (3-1) L: Jack Armstrong (5-14) S: Dennis Eckersley (41) | Sixth | 13½ out |
| Saturday, August 29 |
| » Lost to Athletics (78-51), 4-1 | Oakland-Alameda County Stadium (3-2) | 59-70 | Lost 3 |
| » W: Dave Stewart (10-8) L: Jose Mesa (5-10) S: Dennis Eckersley (42) | Sixth | 13½ out |
| Sunday, August 30 |
| » Lost to Athletics (79-51), 7-5 | Oakland-Alameda County Stadium (3-3) | 59-71 | Lost 4 |
| » W: Ron Darling (12-8) L: Charles Nagy (13-10) S: Rick Honeycutt (3) | Seventh | 14½ out |
| Monday, August 31 |
| » Defeated Angels (59-73), 4-3 | Anaheim Stadium (3-1) | 60-71 | |
| » W: Rod Nichols (3-3) L: Bert Blyleven (7-7) S: Eric Plunk (3) | Sixth | 14½ out |
| Tuesday, September 1 |
| » Lost to Angels (60-73), 7-6 | Anaheim Stadium (3-2) | 60-72 | |
| » W: Chuck Crim (7-5) L: Eric Plunk (5-3) S: Joe Grahe (18) | Sixth | 15½ out |
| Wednesday, September 2 |
| » Lost to Angels (61-73), 3-2 | Anaheim Stadium (3-3) | 60-73 | Lost 2 |
| » W: Scott Lewis (2-0) L: Derek Lilliquist (5-3) | Seventh | 15½ out |
| Friday, September 4 |
| » Defeated Mariners (56-79), 7-0 | Cleveland Stadium (35-34) | 61-73 | |
| » W: Jose Mesa (6-10) L: Dave Fleming (15-7) | Sixth | 15½ out |
| Saturday, September 5 |
| » Defeated Mariners (56-80), 5-4 | Cleveland Stadium (36-34) | 62-73 | Won 2 |
| » W: Eric Plunk (6-3) L: Russ Swan (3-10) | Sixth | 15½ out |
| Sunday, September 6 |
| » Defeated Mariners (56-81), 12-9 | Cleveland Stadium (37-34) | 63-73 | Won 3 |
| » W: Steve Olin (7-4) L: Mike Schooler (2-7) | Fifth | 15½ out |
| Monday, September 7 |
| » Lost to Brewers (74-63), 2-0 | County Stadium (1-4) | 63-74 | |
| » W: Cal Eldred (7-1) L: Dennis Cook (5-7) S: Doug Henry (26) | Sixth | 15½ out |
| Tuesday, September 8 |
| » Lost to Brewers (75-63), 7-3 | County Stadium (1-5) | 63-75 | Lost 2 |
| » W: Ricky Bones (8-9) L: Jack Armstrong (5-15) S: Mike Fetters (2) | Seventh | 16½ out |
| Wednesday, September 9 |
| » Defeated Brewers (75-64), 5-4 | County Stadium (2-5) | 64-75 | |
| » W: Steve Olin (8-4) L: Doug Henry (1-3) | Fifth | 16½ out |
| Friday, September 11 |
| » Defeated White Sox (75-65), 5-1 | Comiskey Park II (1-3) | 65-75 | Won 2 |
| » W: Charles Nagy (14-10) L: Greg Hibbard (10-7) | Fifth | 16 out |
| Saturday, September 12 |
| » Defeated White Sox (75-66), 5-3 | Comiskey Park II (2-3) | 66-75 | Won 3 |
| » W: Eric Plunk (7-3) L: Kirk McCaskill (9-12) S: Steve Olin (24) | Fifth | 16 out |
| » Major-league debuts: Dave Mlicki (Indians) |
| Sunday, September 13 |
| » Defeated White Sox (75-67), 2-1 | Comiskey Park II (3-3) | 67-75 | Won 4 |
| » W: Eric Plunk (8-3) L: Bobby Thigpen (1-3) S: Steve Olin (25) | Fifth | 16 out |
| Monday, September 14 |
| » Defeated Blue Jays (84-61), 2-1 | Skydome (2-2) | 68-75 | Won 5 |
| » W: Jose Mesa (7-10) L: David Cone (15-9) S: Steve Olin (26) | Fifth | 15 out |
| Tuesday, September 15 |
| » Lost to Blue Jays (85-61), 5-4 | Skydome (2-3) | 68-76 | |
| » W: Juan Guzman (15-3) L: Alan Embree (0-1) S: Tom Henke (29) | Fifth | 16 out |
| » Major-league debuts: Alan Embree (Indians) |
| Wednesday, September 16 |
| » Defeated Blue Jays (85-62), 6-3 | Skydome (3-3) | 69-76 | |
| » W: Charles Nagy (15-10) L: Todd Stottlemyre (10-11) S: Ted Power (6) | Fourth | 15 out |
| Thursday, Septembe |