| Monday, April 6 |
| » Defeated Tigers (0-1), 4-2 | Tiger Stadium (1-0) | 1-0 | |
| » W: Jack Morris (1-0) L: Bill Gullickson (0-1) | First | -- |
| Wednesday, April 8 |
| » Defeated Tigers (0-2), 10-9 | Tiger Stadium (2-0) | 2-0 | Won 2 |
| » W: Tom Henke (1-0) L: Frank Tanana (0-1) S: Duane Ward (1) | First | -- |
| » Major-league debuts: John Doherty (Tigers) Ricky Trlicek (Blue Jays) |
| Thursday, April 9 |
| » Defeated Tigers (0-3), 3-1 | Tiger Stadium (3-0) | 3-0 | Won 3 |
| » W: Juan Guzman (1-0) L: Walt Terrell (0-1) S: Duane Ward (2) | First | -- |
| Friday, April 10 |
| » Defeated Orioles (2-2), 4-3 | Skydome (1-0) | 4-0 | Won 4 |
| » W: Pat Hentgen (1-0) L: Gregg Olson (0-1) | First | -- |
| Saturday, April 11 |
| » Defeated Orioles (2-3), 7-2 | Skydome (2-0) | 5-0 | Won 5 |
| » W: Jack Morris (2-0) L: Rick Sutcliffe (1-1) | First | -- |
| Sunday, April 12 |
| » Defeated Orioles (2-4), 3-1 | Skydome (3-0) | 6-0 | Won 6 |
| » W: David Wells (1-0) L: Jose Mesa (0-1) S: Duane Ward (3) | First | -- |
| » Major-league debuts: Jeff Kent (Blue Jays) |
| Monday, April 13 |
| » Lost to Yankees (6-0), 5-2 | Skydome (3-1) | 6-1 | |
| » W: Steve Howe (1-0) L: Todd Stottlemyre (0-1) S: Steve Farr (2) | Second | ½ out |
| Tuesday, April 14 |
| » Defeated Yankees (6-1), 12-6 | Skydome (4-1) | 7-1 | |
| » W: Juan Guzman (2-0) L: Jeff Johnson (0-1) | First | -- |
| Wednesday, April 15 |
| » Defeated Yankees (6-2), 2-0 | Skydome (5-1) | 8-1 | Won 2 |
| » W: Jimmy Key (1-0) L: Melido Perez (1-1) S: Tom Henke (1) | First | -- |
| Thursday, April 16 |
| » Defeated Yankees (6-3), 7-6 | Skydome (6-1) | 9-1 | Won 3 |
| » W: Duane Ward (1-0) L: Steve Farr (0-1) | First | -- |
| Friday, April 17 |
| » Lost to Red Sox (4-4), 1-0 | Fenway Park (0-1) | 9-2 | |
| » W: Roger Clemens (2-1) L: David Wells (1-1) S: Jeff Reardon (2) | First | -- |
| Saturday, April 18 |
| » Defeated Red Sox (4-5), 2-1 | Fenway Park (1-1) | 10-2 | |
| » W: Todd Stottlemyre (1-1) L: Frank Viola (0-2) S: Tom Henke (2) | First | -- |
| Sunday, April 19 |
| » Lost to Red Sox (5-5), 5-4 | Fenway Park (1-2) | 10-3 | |
| » W: Danny Darwin (1-0) L: Tom Henke (1-1) | First | -- |
| Monday, April 20 |
| » Defeated Red Sox (5-6), 6-4 | Fenway Park (2-2) | 11-3 | |
| » W: Rob MacDonald (1-0) L: Tom Bolton (0-1) | First | -- |
| Tuesday, April 21 |
| » Defeated Indians (5-10), 2-1 | Skydome (7-1) | 12-3 | Won 2 |
| » W: Jack Morris (3-0) L: Dennis Cook (0-2) | First | -- |
| Wednesday, April 22 |
| » Lost to Indians (6-10), 7-2 | Skydome (7-2) | 12-4 | |
| » W: Charles Nagy (3-1) L: Dave Stieb (0-1) S: Ted Power (1) | First | -- |
| Thursday, April 23 |
| » Defeated Indians (6-11), 13-8 | Skydome (8-2) | 13-4 | |
| » W: Todd Stottlemyre (2-1) L: Dave Otto (1-2) | First | -- |
| Friday, April 24 |
| » Defeated Royals (1-15), 4-3 | Skydome (9-2) | 14-4 | Won 2 |
| » W: Juan Guzman (3-0) L: Tom Gordon (0-2) S: Tom Henke (3) | First | -- |
| Saturday, April 25 |
| » Defeated Royals (1-16), 6-4 | Skydome (10-2) | 15-4 | Won 3 |
| » W: Pat Hentgen (2-0) L: Curt Young (0-1) S: Duane Ward (4) | First | -- |
| Sunday, April 26 |
| » Lost to Royals (2-16), 9-0 | Skydome (10-3) | 15-5 | |
| » W: Mark Gubicza (1-2) L: Jack Morris (3-1) | First | -- |
| Tuesday, April 28 |
| » Lost to Angels (10-9), 9-5 | Skydome (10-4) | 15-6 | Lost 2 |
| » W: Chuck Finley (1-1) L: Dave Stieb (0-2) | First | -- |
| Wednesday, April 29 |
| » Defeated Angels (10-10), 1-0 | Skydome (11-4) | 16-6 | |
| » W: Todd Stottlemyre (3-1) L: Jim Abbott (1-3) | First | -- |
| Thursday, April 30 |
| » Lost to Brewers (10-9), 3-2 | County Stadium (0-1) | 16-7 | |
| » W: Chris Bosio (2-1) L: Duane Ward (1-1) S: Doug Henry (4) | First | -- |
| Friday, May 1 |
| » Lost to Brewers (11-9), 4-3 | County Stadium (0-2) | 16-8 | Lost 2 |
| » W: Jaime Navarro (2-2) L: Jimmy Key (1-1) S: Doug Henry (5) | First | -- |
| Saturday, May 2 |
| » Lost to Brewers (12-9), 5-4 | County Stadium (0-3) | 16-9 | Lost 3 |
| » W: Mike Fetters (1-0) L: Jack Morris (3-2) S: Doug Henry (6) | Second | 1 out |
| Sunday, May 3 |
| » Defeated Brewers (12-10), 4-1 | County Stadium (1-3) | 17-9 | |
| » W: Dave Stieb (1-2) L: Bill Wegman (2-2) | Second | 1 out |
| Monday, May 4 |
| » Defeated Athletics (15-11), 7-3 | Oakland-Alameda County Stadium (1-0) | 18-9 | Won 2 |
| » W: Todd Stottlemyre (4-1) L: Ron Darling (1-2) | Second | 1 out |
| Tuesday, May 5 |
| » Defeated Athletics (15-12), 5-1 | Oakland-Alameda County Stadium (2-0) | 19-9 | Won 3 |
| » W: Juan Guzman (4-0) L: Joe Slusarski (2-1) S: Duane Ward (5) | First | -- |
| Wednesday, May 6 |
| » Defeated Mariners (11-16), 12-4 | Kingdome (1-0) | 20-9 | Won 4 |
| » W: Jimmy Key (2-1) L: Randy Johnson (3-2) | First | -- |
| Thursday, May 7 |
| » Defeated Mariners (11-17), 8-7 | Kingdome (2-0) | 21-9 | Won 5 |
| » W: Pat Hentgen (3-0) L: Mike Schooler (0-2) S: Tom Henke (4) | First | -- |
| Friday, May 8 |
| » Lost to Angels (16-13), 4-1 | Anaheim Stadium (0-1) | 21-10 | |
| » W: Mark Eichhorn (1-2) L: Dave Stieb (1-3) | First | -- |
| Saturday, May 9 |
| » Lost to Angels (17-13), 2-1 | Anaheim Stadium (0-2) | 21-11 | Lost 2 |
| » W: Jim Abbott (2-4) L: Todd Stottlemyre (4-2) S: Bryan Harvey (10) | Second | 1 out |
| Sunday, May 10 |
| » Defeated Angels (17-14), 4-1 | Anaheim Stadium (1-2) | 22-11 | |
| » W: Juan Guzman (5-0) L: Joe Grahe (2-3) | First | -- |
| Tuesday, May 12 |
| » Defeated Athletics (20-13), 3-0 | Skydome (12-4) | 23-11 | Won 2 |
| » W: Jimmy Key (3-1) L: Dave Stewart (2-3) S: Tom Henke (5) | First | -- |
| Wednesday, May 13 |
| » Defeated Athletics (20-14), 4-3 | Skydome (13-4) | 24-11 | Won 3 |
| » W: Jack Morris (4-2) L: Mike Moore (4-2) S: Tom Henke (6) | First | -- |
| Thursday, May 14 |
| » Defeated Mariners (12-22), 5-4 | Skydome (14-4) | 25-11 | Won 4 |
| » W: Dave Stieb (2-3) L: Calvin Jones (1-1) S: David Wells (1) | First | -- |
| Friday, May 15 |
| » Lost to Mariners (13-22), 2-1 | Skydome (14-5) | 25-12 | |
| » W: Dave Fleming (5-1) L: Todd Stottlemyre (4-3) S: Mike Schooler (6) | First | -- |
| Saturday, May 16 |
| » Lost to Mariners (14-22), 7-6 | Skydome (14-6) | 25-13 | Lost 2 |
| » W: Dennis Powell (1-0) L: David Wells (1-2) S: Mike Schooler (7) | Second | 1½ out |
| Sunday, May 17 |
| » Lost to Mariners (15-22), 3-2 | Skydome (14-7) | 25-14 | Lost 3 |
| » W: Randy Johnson (4-3) L: Jimmy Key (3-2) S: Mike Schooler (8) | Second | 1½ out |
| Monday, May 18 |
| » Lost to Twins (20-17), 6-2 | Skydome (14-8) | 25-15 | Lost 4 |
| » W: Gary Wayne (1-1) L: Duane Ward (1-2) | Second | 1½ out |
| Tuesday, May 19 |
| » Lost to Twins (21-17), 7-1 | Skydome (14-9) | 25-16 | Lost 5 |
| » W: Pat Mahomes (3-1) L: Dave Stieb (2-4) S: Tom Edens (1) | Second | 1½ out |
| Wednesday, May 20 |
| » Defeated Twins (21-18), 8-7 | Skydome (15-9) | 26-16 | |
| » W: Tom Henke (2-1) L: Rick Aguilera (0-4) | First | -- |
| Friday, May 22 |
| » Defeated White Sox (21-17), 6-2 | Comiskey Park II (1-0) | 27-16 | Won 2 |
| » W: Juan Guzman (6-0) L: Jack McDowell (7-2) S: Duane Ward (6) | First | -- |
| Saturday, May 23 |
| » Lost to White Sox (22-17), 5-2 | Comiskey Park II (1-1) | 27-17 | |
| » W: Greg Hibbard (5-2) L: Jimmy Key (3-3) S: Bobby Thigpen (12) | First | -- |
| Sunday, May 24 |
| » Lost to White Sox (23-17), 8-1 | Comiskey Park II (1-2) | 27-18 | Lost 2 |
| » W: Kirk McCaskill (3-4) L: Jack Morris (4-3) | Second | 1½ out |
| Tuesday, May 26 |
| » Defeated Brewers (20-23), 5-4 | Skydome (16-9) | 28-18 | |
| » W: Dave Stieb (3-4) L: Ricky Bones (1-2) S: Tom Henke (7) | Second | 1 out |
| Wednesday, May 27 |
| » Lost to Brewers (21-23), 8-4 | Skydome (16-10) | 28-19 | |
| » W: Jaime Navarro (4-4) L: Todd Stottlemyre (4-4) S: Doug Henry (7) | Second | 1 out |
| Friday, May 29 |
| » Defeated White Sox (23-21), 3-0 | Skydome (17-10) | 29-19 | |
| » W: Duane Ward (2-2) L: Greg Hibbard (5-3) S: Tom Henke (8) | First | -- |
| Saturday, May 30 |
| » Defeated White Sox (23-22), 2-1 | Skydome (18-10) | 30-19 | Won 2 |
| » W: David Wells (2-2) L: Donn Pall (2-2) | First | -- |
| Sunday, May 31 |
| » Defeated White Sox (23-23), 3-2 | Skydome (19-10) | 31-19 | Won 3 |
| » W: Jack Morris (5-3) L: Bobby Thigpen (0-2) | First | -- |
| Monday, June 1 |
| » Defeated Twins (27-21), 5-3 | Hubert H. Humphrey Metrodome (1-0) | 32-19 | Won 4 |
| » W: Duane Ward (3-2) L: Carl Willis (1-2) S: Tom Henke (9) | First | -- |
| Tuesday, June 2 |
| » Defeated Twins (27-22), 7-5 | Hubert H. Humphrey Metrodome (2-0) | 33-19 | Won 5 |
| » W: Pat Hentgen (4-0) L: Gary Wayne (1-2) S: Tom Henke (10) | First | -- |
| Wednesday, June 3 |
| » Lost to Twins (28-22), 11-3 | Hubert H. Humphrey Metrodome (2-1) | 33-20 | |
| » W: Kevin Tapani (6-4) L: Juan Guzman (6-1) | First | -- |
| » Major-league debuts: J.T. Bruett (Twins) |
| Friday, June 5 |
| » Lost to Orioles (32-20), 1-0 | Oriole Park at Camden Yards (0-1) | 33-21 | Lost 2 |
| » W: Rick Sutcliffe (8-4) L: Jimmy Key (3-4) S: Gregg Olson (14) | Second | 1 out |
| Saturday, June 6 |
| » Defeated Orioles (32-21), 4-3 | Oriole Park at Camden Yards (1-1) | 34-21 | |
| » W: Jack Morris (6-3) L: Ben McDonald (7-3) S: Tom Henke (11) | First | -- |
| Sunday, June 7 |
| » Lost to Orioles (33-21), 7-1 | Oriole Park at Camden Yards (1-2) | 34-22 | |
| » W: Mike Mussina (7-1) L: Dave Stieb (3-5) | Second | 1 out |
| Monday, June 8 |
| » Defeated Yankees (28-27), 16-3 | Yankee Stadium (1-0) | 35-22 | |
| » W: Todd Stottlemyre (5-4) L: Greg Cadaret (3-5) | Second | 1 out |
| Tuesday, June 9 |
| » Defeated Yankees (28-28), 2-1 | Yankee Stadium (2-0) | 36-22 | Won 2 |
| » W: Juan Guzman (7-1) L: Tim Leary (4-5) S: Tom Henke (12) | First | -- |
| Wednesday, June 10 |
| » Defeated Yankees (28-29), 10-3 | Yankee Stadium (3-0) | 37-22 | Won 3 |
| » W: Jimmy Key (4-4) L: Scott Sanderson (4-4) S: David Wells (2) | First | -- |
| Thursday, June 11 |
| » Defeated Red Sox (27-28), 4-0 | Skydome (20-10) | 38-22 | Won 4 |
| » W: Jack Morris (7-3) L: Roger Clemens (9-4) | First | -- |
| Friday, June 12 |
| » Lost to Red Sox (28-28), 5-0 | Skydome (20-11) | 38-23 | |
| » W: Frank Viola (6-4) L: Dave Stieb (3-6) | Second | 1 out |
| Saturday, June 13 |
| » Lost to Red Sox (29-28), 5-3 | Skydome (20-12) | 38-24 | Lost 2 |
| » W: Joe Hesketh (3-3) L: Todd Stottlemyre (5-5) S: Jeff Reardon (14) | Second | 1 out |
| Sunday, June 14 |
| » Defeated Red Sox (29-29), 6-2 | Skydome (21-12) | 39-24 | |
| » W: Juan Guzman (8-1) L: Mike Gardiner (3-6) S: Duane Ward (7) | First | -- |
| Tuesday, June 16 |
| » Lost to Tigers (28-35), 4-3 | Skydome (21-13) | 39-25 | |
| » W: Bill Gullickson (8-4) L: Jimmy Key (4-5) S: Mike Henneman (10) | First | -- |
| Wednesday, June 17 |
| » Defeated Tigers (28-36), 6-2 | Skydome (22-13) | 40-25 | |
| » W: Jack Morris (8-3) L: Kevin Ritz (1-2) S: Duane Ward (8) | First | -- |
| Thursday, June 18 |
| » Lost to Tigers (29-36), 14-10 | Skydome (22-14) | 40-26 | |
| » W: Mike Munoz (1-1) L: Mike Timlin (0-1) S: Mike Henneman (11) | First | -- |
| Friday, June 19 |
| » Lost to Royals (27-38), 11-4 | Royals Stadium (0-1) | 40-27 | Lost 2 |
| » W: Mark Gubicza (7-4) L: Todd Stottlemyre (5-6) | Second | 1 out |
| Saturday, June 20 |
| » Defeated Royals (27-39), 6-1 | Royals Stadium (1-1) | 41-27 | |
| » W: Juan Guzman (9-1) L: Mike Magnante (3-6) | First | -- |
| Sunday, June 21 |
| » Lost to Royals (28-39), 2-0 | Royals Stadium (1-2) | 41-28 | |
| » W: Kevin Appier (7-3) L: Jimmy Key (4-6) S: Jeff Montgomery (16) | First | -- |
| Monday, June 22 |
| » Defeated Rangers (39-33), 16-7 | Arlington Stadium (1-0) | 42-28 | |
| » W: Jack Morris (9-3) L: Jose Guzman (6-5) | First | -- |
| Wednesday, June 24 |
| » Defeated Rangers (39-34), 3-2 | Arlington Stadium (2-0) | 43-28 | Won 2 |
| » W: David Wells (3-2) L: Bobby Witt (8-6) S: Tom Henke (13) | First | -- |
| Friday, June 26 |
| » Defeated Indians (28-45), 6-1 | Cleveland Stadium (1-0) | 44-28 | Won 3 |
| » W: Juan Guzman (10-1) L: Jack Armstrong (2-9) | First | -- |
| Saturday, June 27 |
| » Lost to Indians (29-45), 6-4 | Cleveland Stadium (1-1) | 44-29 | |
| » W: Eric Plunk (1-0) L: Duane Ward (3-3) | First | -- |
| Sunday, June 28 |
| » Lost to Indians (30-45), 7-6 | Cleveland Stadium (1-2) | 44-30 | Lost 2 |
| » W: Steve Olin (2-3) L: Duane Ward (3-4) S: Eric Plunk (1) | First | -- |
| Monday, June 29 |
| » Defeated Rangers (42-36), 11-4 | Skydome (23-14) | 45-30 | |
| » W: Pat Hentgen (5-0) L: Bobby Witt (8-7) | First | -- |
| Tuesday, June 30 |
| » Lost to Rangers (43-36), 16-13 | Skydome (23-15) | 45-31 | |
| » W: Kevin Brown (12-4) L: David Wells (3-3) | First | -- |
| Wednesday, July 1 |
| » Defeated Rangers (43-37), 3-2 | Skydome (24-15) | 46-31 | |
| » W: Duane Ward (4-4) L: Jeff Russell (2-3) | First | -- |
| Friday, July 3 |
| » Defeated Angels (32-46), 10-1 | Skydome (25-15) | 47-31 | Won 2 |
| » W: Jimmy Key (5-6) L: Mark Langston (8-6) | First | -- |
| Saturday, July 4 |
| » Defeated Angels (32-47), 8-6 | Skydome (26-15) | 48-31 | Won 3 |
| » W: Jack Morris (10-3) L: Mark Eichhorn (1-4) S: Tom Henke (14) | First | -- |
| Sunday, July 5 |
| » Defeated Angels (32-48), 6-2 | Skydome (27-15) | 49-31 | Won 4 |
| » W: David Wells (4-3) L: Julio Valera (4-8) | First | -- |
| Monday, July 6 |
| » Defeated Angels (32-49), 3-0 | Skydome (28-15) | 50-31 | Won 5 |
| » W: Juan Guzman (11-1) L: Jim Abbott (4-11) S: Tom Henke (15) | First | -- |
| » Major-league debuts: Mike Butcher (Angels) |
| Tuesday, July 7 |
| » Defeated Mariners (33-51), 4-3 | Skydome (29-15) | 51-31 | Won 6 |
| » W: Duane Ward (5-4) L: Jeff Nelson (0-4) | First | -- |
| Wednesday, July 8 |
| » Defeated Mariners (33-52), 6-0 | Skydome (30-15) | 52-31 | Won 7 |
| » W: Jimmy Key (6-6) L: Erik Hanson (6-11) | First | -- |
| Thursday, July 9 |
| » Defeated Athletics (48-36), 4-3 | Skydome (31-15) | 53-31 | Won 8 |
| » W: Tom Henke (3-1) L: Rich Gossage (0-2) | First | -- |
| Friday, July 10 |
| » Lost to Athletics (49-36), 5-1 | Skydome (31-16) | 53-32 | |
| » W: Bob Welch (7-4) L: David Wells (4-4) | First | -- |
| Saturday, July 11 |
| » Lost to Athletics (50-36), 3-1 | Skydome (31-17) | 53-33 | Lost 2 |
| » W: Mike Moore (10-7) L: Juan Guzman (11-2) S: Dennis Eckersley (30) | First | -- |
| Sunday, July 12 |
| » Lost to Athletics (51-36), 8-0 | Skydome (31-18) | 53-34 | Lost 3 |
| » W: Ron Darling (8-7) L: Pat Hentgen (5-1) | First | -- |
| Thursday, July 16 |
| » Defeated Mariners (36-54), 7-2 | Kingdome (3-0) | 54-34 | |
| » W: Jack Morris (11-3) L: Randy Johnson (5-10) | First | -- |
| Friday, July 17 |
| » Lost to Mariners (37-54), 8-6 | Kingdome (3-1) | 54-35 | |
| » W: Erik Hanson (8-11) L: Jimmy Key (6-7) S: Russ Swan (6) | First | -- |
| Saturday, July 18 |
| » Defeated Mariners (37-55), 3-0 | Kingdome (4-1) | 55-35 | |
| » W: Juan Guzman (12-2) L: Dave Fleming (11-4) S: Tom Henke (16) | First | -- |
| Sunday, July 19 |
| » Defeated Mariners (37-56), 8-4 | Kingdome (5-1) | 56-35 | Won 2 |
| » W: David Wells (5-4) L: Rich DeLucia (3-6) | First | -- |
| » Major-league debuts: Kerry Woodson (Mariners) |
| Monday, July 20 |
| » Lost to Angels (39-53), 5-3 | Anaheim Stadium (1-3) | 56-36 | |
| » W: Chuck Crim (4-2) L: Pat Hentgen (5-2) S: Joe Grahe (6) | First | -- |
| » Major-league debuts: Tim Fortugno (Angels) |
| Tuesday, July 21 |
| » Defeated Angels (39-54), 9-5 | Anaheim Stadium (2-3) | 57-36 | |
| » W: Jack Morris (12-3) L: Chuck Crim (4-3) S: Duane Ward (9) | First | -- |
| Wednesday, July 22 |
| » Lost to Angels (40-54), 5-4 | Anaheim Stadium (2-4) | 57-37 | |
| » W: Joe Grahe (3-3) L: Jimmy Key (6-8) | First | -- |
| Thursday, July 23 |
| » Defeated Athletics (54-41), 9-3 | Oakland-Alameda County Stadium (3-0) | 58-37 | |
| » W: Dave Stieb (4-6) L: Mike Moore (10-9) | First | -- |
| Friday, July 24 |
| » Lost to Athletics (55-41), 6-5 | Oakland-Alameda County Stadium (3-1) | 58-38 | |
| » W: Dennis Eckersley (3-0) L: Tom Henke (3-2) | First | -- |
| Saturday, July 25 |
| » Lost to Athletics (56-41), 6-0 | Oakland-Alameda County Stadium (3-2) | 58-39 | Lost 2 |
| » W: Ron Darling (9-8) L: Todd Stottlemyre (5-7) | First | -- |
| Sunday, July 26 |
| » Lost to Athletics (57-41), 9-1 | Oakland-Alameda County Stadium (3-3) | 58-40 | Lost 3 |
| » W: Kelly Downs (3-4) L: Jack Morris (12-4) | First | -- |
| Tuesday, July 28 |
| » Defeated Royals (43-56), 6-4 | Skydome (32-18) | 59-40 | |
| » W: Jimmy Key (7-8) L: Dennis Moeller (0-1) S: Tom Henke (17) | First | -- |
| » Major-league debuts: Dennis Moeller (Royals) |
| Wednesday, July 29 |
| » Lost to Royals (44-56), 5-2 | Skydome (32-19) | 59-41 | |
| » W: Kevin Appier (12-3) L: Mike Timlin (0-2) S: Jeff Montgomery (25) | First | -- |
| Thursday, July 30 |
| » Defeated Royals (44-57), 3-0 | Skydome (33-19) | 60-41 | |
| » W: David Wells (6-4) L: Luis Aquino (1-2) S: Tom Henke (18) | First | -- |
| Friday, July 31 |
| » Defeated Yankees (48-54), 13-2 | Skydome (34-19) | 61-41 | Won 2 |
| » W: Todd Stottlemyre (6-7) L: Shawn Hillegas (1-5) | First | -- |
| Saturday, August 1 |
| » Defeated Yankees (48-55), 3-1 | Skydome (35-19) | 62-41 | Won 3 |
| » W: Jack Morris (13-4) L: Melido Perez (9-10) S: Tom Henke (19) | First | -- |
| Sunday, August 2 |
| » Defeated Yankees (48-56), 7-6 | Skydome (36-19) | 63-41 | Won 4 |
| » W: Mark Eichhorn (3-4) L: John Habyan (3-5) S: Duane Ward (10) | First | -- |
| Monday, August 3 |
| » Lost to Red Sox (49-55), 7-1 | Fenway Park (2-3) | 63-42 | |
| » W: Roger Clemens (12-7) L: Juan Guzman (12-3) | First | -- |
| » Major-league debuts: Doug Linton (Blue Jays) |
| Tuesday, August 4 |
| » Lost to Red Sox (50-55), 9-4 | Fenway Park (2-4) | 63-43 | Lost 2 |
| » W: Joe Hesketh (6-8) L: David Wells (6-5) S: Greg Harris (2) | First | -- |
| Wednesday, August 5 |
| » Defeated Red Sox (50-56), 5-4 | Fenway Park (3-4) | 64-43 | |
| » W: Mark Eichhorn (4-4) L: Daryl Irvine (2-1) S: Tom Henke (20) | First | -- |
| Thursday, August 6 |
| » Defeated Tigers (49-61), 15-11 | Tiger Stadium (4-0) | 65-43 | Won 2 |
| » W: Jack Morris (14-4) L: Frank Tanana (9-7) | First | -- |
| Friday, August 7 |
| » Lost to Tigers (50-61), 7-2 | Tiger Stadium (4-1) | 65-44 | |
| » W: Bill Gullickson (13-7) L: Jimmy Key (7-9) | First | -- |
| Saturday, August 8 |
| » Lost to Tigers (51-61), 8-6 | Tiger Stadium (4-2) | 65-45 | Lost 2 |
| » W: John Kiely (4-1) L: Doug Linton (0-1) S: Mike Henneman (19) | First | -- |
| » Major-league debuts: Rico Brogna (Tigers) |
| Sunday, August 9 |
| » Lost to Tigers (52-61), 9-2 | Tiger Stadium (4-3) | 65-46 | Lost 3 |
| » W: Dave Haas (1-0) L: David Wells (6-6) | First | -- |
| Monday, August 10 |
| » Defeated Orioles (63-49), 8-4 | Skydome (37-19) | 66-46 | |
| » W: Todd Stottlemyre (7-7) L: Mike Mussina (11-5) | First | -- |
| Tuesday, August 11 |
| » Lost to Orioles (64-49), 3-0 | Skydome (37-20) | 66-47 | |
| » W: Alan Mills (8-2) L: Jack Morris (14-5) S: Gregg Olson (27) | First | -- |
| Wednesday, August 12 |
| » Lost to Orioles (65-49), 11-4 | Skydome (37-21) | 66-48 | Lost 2 |
| » W: Ben McDonald (12-7) L: Jimmy Key (7-10) | First | -- |
| Thursday, August 13 |
| » Defeated Orioles (65-50), 4-2 | Skydome (38-21) | 67-48 | |
| » W: Doug Linton (1-1) L: Arthur Rhodes (4-2) S: Tom Henke (21) | First | -- |
| Friday, August 14 |
| » Defeated Indians (52-64), 9-5 | Cleveland Stadium (2-2) | 68-48 | Won 2 |
| » W: David Wells (7-6) L: Rod Nichols (2-3) | First | -- |
| Sunday, August 16 |
| » Lost to Indians (53-64), 4-2 | Cleveland Stadium (2-3) | 68-49 | |
| » W: Dennis Cook (4-5) L: Todd Stottlemyre (7-8) S: Steve Olin (21) | First | -- |
| » Defeated Indians (53-65), 6-2 | Cleveland Stadium (3-3) | 69-49 | |
| » W: Jack Morris (15-5) L: Dave Otto (5-9) | First | -- |
| Tuesday, August 18 |
| » Defeated Brewers (63-55), 12-1 | County Stadium (2-3) | 70-49 | Won 2 |
| » W: Jimmy Key (8-10) L: Bruce Ruffin (1-5) | First | -- |
| Wednesday, August 19 |
| » Lost to Brewers (64-55), 10-5 | County Stadium (2-4) | 70-50 | |
| » W: Chris Bosio (11-5) L: Doug Linton (1-2) | First | -- |
| Thursday, August 20 |
| » Lost to Brewers (65-55), 16-3 | County Stadium (2-5) | 70-51 | Lost 2 |
| » W: Bill Wegman (11-10) L: David Wells (7-7) | First | -- |
| Friday, August 21 |
| » Lost to Twins (68-54), 5-1 | Hubert H. Humphrey Metrodome (2-2) | 70-52 | Lost 3 |
| » W: John Smiley (13-6) L: Todd Stottlemyre (7-9) | First | -- |
| Saturday, August 22 |
| » Defeated Twins (68-55), 4-2 | Hubert H. Humphrey Metrodome (3-2) | 71-52 | |
| » W: Jack Morris (16-5) L: David West (1-2) S: Tom Henke (22) | First | -- |
| Sunday, August 23 |
| » Lost to Twins (69-55), 2-0 | Hubert H. Humphrey Metrodome (3-3) | 71-53 | |
| » W: Scott Erickson (9-10) L: Jimmy Key (8-11) | First | -- |
| Monday, August 24 |
| » Lost to White Sox (66-57), 8-4 | Comiskey Park II (1-3) | 71-54 | Lost 2 |
| » W: Alex Fernandez (6-7) L: Doug Linton (1-3) | First | -- |
| Tuesday, August 25 |
| » Lost to White Sox (67-57), 6-3 | Comiskey Park II (1-4) | 71-55 | Lost 3 |
| » W: Charlie Hough (6-10) L: David Wells (7-8) S: Roberto Hernandez (4) | First | -- |
| Wednesday, August 26 |
| » Defeated White Sox (67-58), 9-0 | Comiskey Park II (2-4) | 72-55 | |
| » W: Todd Stottlemyre (8-9) L: Kirk McCaskill (9-10) | First | -- |
| Thursday, August 27 |
| » Defeated Brewers (67-60), 5-4 | Skydome (39-21) | 73-55 | Won 2 |
| » W: Jack Morris (17-5) L: Jaime Navarro (14-9) S: Tom Henke (23) | First | -- |
| Friday, August 28 |
| » Lost to Brewers (68-60), 22-2 | Skydome (39-22) | 73-56 | |
| » W: Cal Eldred (5-1) L: Jimmy Key (8-12) | First | -- |
| Saturday, August 29 |
| » Lost to Brewers (69-60), 7-2 | Skydome (39-23) | 73-57 | Lost 2 |
| » W: Chris Bosio (12-5) L: David Cone (13-8) S: Darren Holmes (3) | First | -- |
| Sunday, August 30 |
| » Defeated Brewers (69-61), 5-3 | Skydome (40-23) | 74-57 | |
| » W: Duane Ward (6-4) L: Bill Wegman (11-12) S: Tom Henke (24) | First | -- |
| Monday, August 31 |
| » Defeated White Sox (68-61), 9-2 | Skydome (41-23) | 75-57 | Won 2 |
| » W: Todd Stottlemyre (9-9) L: Charlie Hough (6-11) | First | -- |
| Tuesday, September 1 |
| » Defeated White Sox (68-62), 9-3 | Skydome (42-23) | 76-57 | Won 3 |
| » W: Jack Morris (18-5) L: Kirk McCaskill (9-11) | First | -- |
| Wednesday, September 2 |
| » Lost to White Sox (69-62), 3-2 | Skydome (42-24) | 76-58 | |
| » W: Greg Hibbard (10-6) L: Jimmy Key (8-13) S: Roberto Hernandez (6) | First | -- |
| » Major-league debuts: Mike Maksudian (Blue Jays) |
| Friday, September 4 |
| » Defeated Twins (75-60), 16-5 | Skydome (43-24) | 77-58 | |
| » W: David Cone (14-8) L: Kevin Tapani (14-10) | First | -- |
| Saturday, September 5 |
| » Defeated Twins (75-61), 7-3 | Skydome (44-24) | 78-58 | Won 2 |
| » W: Juan Guzman (13-3) L: John Smiley (14-7) | First | -- |
| Sunday, September 6 |
| » Defeated Twins (75-62), 4-2 | Skydome (45-24) | 79-58 | Won 3 |
| » W: Todd Stottlemyre (10-9) L: Mike Trombley (0-1) S: Tom Henke (25) | First | -- |
| Monday, September 7 |
| » Lost to Royals (62-75), 5-4 | Royals Stadium (1-3) | 79-59 | |
| » W: Mike Magnante (4-7) L: David Wells (7-9) | First | -- |
| Tuesday, September 8 |
| » Defeated Royals (62-76), 5-0 | Royals Stadium (2-3) | 80-59 | |
| » W: Jimmy Key (9-13) L: Luis Aquino (2-5) | First | -- |
| Wednesday, September 9 |
| » Defeated Royals (62-77), 1-0 | Royals Stadium (3-3) | 81-59 | Won 2 |
| » W: David Cone (15-8) L: Kevin Appier (15-8) S: Tom Henke (26) | First | -- |
| Friday, September 11 |
| » Defeated Rangers (69-74), 7-5 | Arlington Stadium (3-0) | 82-59 | Won 3 |
| » W: Juan Guzman (14-3) L: Scott Chiamparino (0-2) S: Tom Henke (27) | First | -- |
| » Lost to Rangers (70-74), 4-3 | Arlington Stadium (3-1) | 82-60 | |
| » W: Roger Pavlik (4-2) L: Todd Stottlemyre (10-10) S: Todd Burns (1) | First | -- |
| » Major-league debuts: Domingo Martinez (Blue Jays) |
| Saturday, September 12 |
| » Defeated Rangers (70-75), 4-2 | Arlington Stadium (4-1) | 83-60 | |
| » W: Jack Morris (19-5) L: Dan Smith (0-1) S: Tom Henke (28) | First | -- |
| » Major-league debuts: Dan Smith (Rangers) |
| Sunday, September 13 |
| » Defeated Rangers (70-76), 7-2 | Arlington Stadium (5-1) | 84-60 | Won 2 |
| » W: Jimmy Key (10-13) L: Kevin Brown (19-9) S: Duane Ward (11) | First | -- |
| Monday, September 14 |
| » Lost to Indians (68-75), 2-1 | Skydome (45-25) | 84-61 | |
| » W: Jose Mesa (7-10) L: David Cone (15-9) S: Steve Olin (26) | First | -- |
| Tuesday, September 15 |
| » Defeated Indians (68-76), 5-4 | Skydome (46-25) | 85-61 | |
| » W: Juan Guzman (15-3) L: Alan Embree (0-1) S: Tom Henke (29) | First | -- |
| » Major-league debuts: Alan Embree (Indians) |
| Wednesday, September 16 |
| » Lost to Indians (69-76), 6-3 | Skydome (46-26) | 85-62 | |
| » W: Charles Nagy (15-10) L: Todd Stottlemyre (10-11) S: Ted Power (6) | First | -- |
| Thursday, September 17 |
| » Defeated Indians (69-77), 7-5 | Skydome (47-26) | 86-62 | |
| » W: Duane Ward (7-4) L: Eric Plunk (8-4) | First | -- |
| Friday, September 18 |
| » Defeated Rangers (71-78), 13-0 | Skydome (48-26) | 87-62 | Won 2 |
| » W: Jimmy Key (11-13) L: Kevin Brown (19-10) | First | -- |
| » Major-league debuts: Cris Colon (Rangers) |
| Saturday, September 19 |
| » Defeated Rangers (71-79), 1-0 | Skydome (49-26) | 88-62 | Won 3 |
| » W: David Cone (16-9) L: Scott Chiamparino (0-3) S: Tom Henke (30) | First | -- |
| Sunday, September 20 |
| » Lost to Rangers (72-79), 7-5 | Skydome (49-27) | 88-63 | |
| » W: Jose Guzman (15-11) L: Juan Guzman (15-4) S: Matt Whiteside (2) | First | -- |
| Tuesday, September 22 |
| » Defeated Orioles (82-68), 4-3 | Oriole Park at Camden Yards (2-2) | 89-63 | |
| » W: Todd Stottlemyre (11-11) L: Rick Sutcliffe (16-14) S: Tom Henke (31) | First | -- |
| Wednesday, September 23 |
