| Tuesday, April 7 |
| » Lost to Braves (1-0), 2-0 | Astrodome (0-1) | 0-1 | |
| » W: Tom Glavine (1-0) L: Pete Harnisch (0-1) | Third | 1 out |
| Wednesday, April 8 |
| » Lost to Braves (2-0), 3-1 | Astrodome (0-2) | 0-2 | Lost 2 |
| » W: John Smoltz (1-0) L: Darryl Kile (0-1) S: Alejandro Pena (1) | Fifth | 2 out |
| Thursday, April 9 |
| » Defeated Reds (1-3), 6-5 | Astrodome (1-2) | 1-2 | |
| » W: Al Osuna (1-0) L: Scott Ruskin (0-1) | Third | 1 out |
| » Major-league debuts: Juan Guerrero and Butch Henry (Astros) |
| Friday, April 10 |
| » Lost to Reds (2-3), 8-5 | Astrodome (1-3) | 1-3 | |
| » W: Chris Hammond (1-0) L: Ryan Bowen (0-1) S: Norm Charlton (2) | Fifth | 2 out |
| Saturday, April 11 |
| » Defeated Reds (2-4), 2-1 | Astrodome (2-3) | 2-3 | |
| » W: Al Osuna (2-0) L: Jose Rijo (0-2) S: Doug Jones (1) | Third | 1½ out |
| Sunday, April 12 |
| » Lost to Reds (3-4), 5-4 | Astrodome (2-4) | 2-4 | |
| » W: Tom Browning (2-0) L: Pete Harnisch (0-2) S: Norm Charlton (3) | Fifth | 2½ out |
| » Major-league debuts: Jeff Branson (Reds) |
| Monday, April 13 |
| » Defeated Dodgers (2-5), 8-3 | Astrodome (3-4) | 3-4 | |
| » W: Darryl Kile (1-1) L: Orel Hershiser (1-1) S: Doug Jones (2) | Fifth | 2 out |
| Tuesday, April 14 |
| » Lost to Dodgers (3-5), 6-2 | Astrodome (3-5) | 3-5 | |
| » W: Tom Candiotti (2-0) L: Butch Henry (0-1) | Fifth | 3 out |
| Wednesday, April 15 |
| » Defeated Dodgers (3-6), 5-4 | Astrodome (4-5) | 4-5 | |
| » W: Mark Portugal (1-0) L: Bob Ojeda (0-2) S: Doug Jones (3) | Third | 3 out |
| Friday, April 17 |
| » Defeated Padres (7-4), 3-1 | Astrodome (5-5) | 5-5 | Won 2 |
| » W: Pete Harnisch (1-2) L: Bruce Hurst (0-1) S: Doug Jones (4) | Third | 1½ out |
| Saturday, April 18 |
| » Defeated Padres (7-5), 4-2 | Astrodome (6-5) | 6-5 | Won 3 |
| » W: Doug Jones (1-0) L: Randy Myers (1-1) | Second | ½ out |
| Sunday, April 19 |
| » Defeated Padres (7-6), 1-0 | Astrodome (7-5) | 7-5 | Won 4 |
| » W: Xavier Hernandez (1-0) L: Rich Rodriguez (0-1) | First | -- |
| Monday, April 20 |
| » Defeated Giants (7-6), 3-2 | Astrodome (8-5) | 8-5 | Won 5 |
| » W: Mark Portugal (2-0) L: Dave Burba (0-2) S: Doug Jones (5) | First | -- |
| Tuesday, April 21 |
| » Lost to Giants (8-6), 6-2 | Astrodome (8-6) | 8-6 | |
| » W: Bill Swift (4-0) L: Ryan Bowen (0-2) | First | -- |
| Wednesday, April 22 |
| » Defeated Giants (8-7), 3-1 | Astrodome (9-6) | 9-6 | |
| » W: Xavier Hernandez (2-0) L: Mike Jackson (0-1) | First | -- |
| Friday, April 24 |
| » Defeated Braves (6-11), 4-2 | Atlanta-Fulton County Stadium (1-0) | 10-6 | Won 2 |
| » W: Darryl Kile (2-1) L: John Smoltz (1-2) S: Doug Jones (6) | First | -- |
| Saturday, April 25 |
| » Lost to Braves (7-11), 2-0 | Atlanta-Fulton County Stadium (1-1) | 10-7 | |
| » W: Steve Avery (1-2) L: Mark Portugal (2-1) | First | -- |
| Sunday, April 26 |
| » Lost to Braves (8-11), 3-2 | Atlanta-Fulton County Stadium (1-2) | 10-8 | Lost 2 |
| » W: Marvin Freeman (2-1) L: Pete Harnisch (1-3) S: Alejandro Pena (2) | First | -- |
| Monday, April 27 |
| » Major-league debuts: Dave Silvestri (Yankees) |
| Tuesday, April 28 |
| » Lost to Mets (11-9), 4-0 | Shea Stadium (0-1) | 10-9 | Lost 3 |
| » W: David Cone (2-1) L: Butch Henry (0-2) | Second | ½ out |
| Wednesday, April 29 |
| » Lost to Mets (12-9), 1-0 | Shea Stadium (0-2) | 10-10 | Lost 4 |
| » W: Bret Saberhagen (1-2) L: Darryl Kile (2-2) | Third | 1 out |
| Thursday, April 30 |
| » Lost to Mets (13-9), 4-3 | Shea Stadium (0-3) | 10-11 | Lost 5 |
| » W: Jeff Innis (3-1) L: Doug Jones (1-1) S: John Franco (4) | Fifth | 1½ out |
| Friday, May 1 |
| » Defeated Pirates (15-6), 10-4 | Astrodome (10-6) | 11-11 | |
| » W: Pete Harnisch (2-3) L: Randy Tomlin (4-1) | Third | 1 out |
| Saturday, May 2 |
| » Lost to Pirates (16-6), 6-0 | Astrodome (10-7) | 11-12 | |
| » W: Denny Neagle (1-0) L: Ryan Bowen (0-3) | Fifth | 2 out |
| Sunday, May 3 |
| » Defeated Pirates (16-7), 1-0 | Astrodome (11-7) | 12-12 | |
| » W: Al Osuna (3-0) L: Roger Mason (1-2) S: Doug Jones (7) | Second | 1 out |
| Monday, May 4 |
| » Lost to Mets (16-10), 5-1 | Astrodome (11-8) | 12-13 | |
| » W: Bret Saberhagen (2-2) L: Darryl Kile (2-3) | Fourth | 1½ out |
| Tuesday, May 5 |
| » Defeated Mets (16-11), 5-4 | Astrodome (12-8) | 13-13 | |
| » W: Mark Portugal (3-1) L: Sid Fernandez (1-3) S: Doug Jones (8) | Second | ½ out |
| Wednesday, May 6 |
| » Lost to Cubs (10-16), 8-4 | Wrigley Field (0-1) | 13-14 | |
| » W: Greg Maddux (4-2) L: Pete Harnisch (2-4) | Third | 1 out |
| Thursday, May 7 |
| » Lost to Cubs (11-16), 9-2 | Wrigley Field (0-2) | 13-15 | Lost 2 |
| » W: Mike Morgan (2-2) L: Ryan Bowen (0-4) | Fourth | 2 out |
| Friday, May 8 |
| » Lost to Pirates (20-8), 6-3 | Three Rivers Stadium (0-1) | 13-16 | Lost 3 |
| » W: Stan Belinda (1-0) L: Al Osuna (3-1) | Fifth | 3 out |
| Saturday, May 9 |
| » Lost to Pirates (21-8), 3-0 | Three Rivers Stadium (0-2) | 13-17 | Lost 4 |
| » W: Zane Smith (5-1) L: Darryl Kile (2-4) | Fifth | 3 out |
| Sunday, May 10 |
| » Defeated Pirates (21-9), 6-4 | Three Rivers Stadium (1-2) | 14-17 | |
| » W: Doug Jones (2-1) L: Roger Mason (1-3) | Fifth | 3 out |
| Monday, May 11 |
| » Defeated Cubs (12-19), 2-1 | Astrodome (13-8) | 15-17 | Won 2 |
| » W: Xavier Hernandez (3-0) L: Chuck McElroy (2-2) | Third | 2½ out |
| Tuesday, May 12 |
| » Lost to Cubs (13-19), 3-2 | Astrodome (13-9) | 15-18 | |
| » W: Paul Assenmacher (1-1) L: Joe Boever (0-1) | Fifth | 3½ out |
| » Major-league debuts: Alex Arias (Cubs) |
| Wednesday, May 13 |
| » Lost to Cubs (14-19), 8-3 | Astrodome (13-10) | 15-19 | Lost 2 |
| » W: Shawn Boskie (4-2) L: Butch Henry (0-3) | Fifth | 4½ out |
| Friday, May 15 |
| » Lost to Cardinals (21-14), 7-5 | Astrodome (13-11) | 15-20 | Lost 3 |
| » W: Bob McClure (1-0) L: Doug Jones (2-2) S: Lee Smith (13) | Fifth | 4½ out |
| Saturday, May 16 |
| » Defeated Cardinals (21-15), 3-2 | Astrodome (14-11) | 16-20 | |
| » W: Doug Jones (3-2) L: Juan Agosto (2-3) | Fifth | 4½ out |
| Sunday, May 17 |
| » Lost to Cardinals (22-15), 7-5 | Astrodome (14-12) | 16-21 | |
| » W: Cris Carpenter (2-1) L: Doug Jones (3-3) S: Lee Smith (14) | Fifth | 4½ out |
| » Major-league debuts: Bien Figueroa (Cardinals) |
| Monday, May 18 |
| » Defeated Phillies (15-21), 4-2 | Veteran's Stadium (1-0) | 17-21 | |
| » W: Jimmy Jones (1-0) L: Kyle Abbott (0-7) S: Joe Boever (1) | Fifth | 4 out |
| Tuesday, May 19 |
| » Lost to Phillies (16-21), 4-3 | Veteran's Stadium (1-1) | 17-22 | |
| » W: Curt Schilling (3-2) L: Butch Henry (0-4) S: Mitch Williams (5) | Fifth | 5 out |
| Wednesday, May 20 |
| » Lost to Phillies (17-21), 2-1 | Veteran's Stadium (1-2) | 17-23 | Lost 2 |
| » W: Terry Mulholland (4-3) L: Darryl Kile (2-5) S: Mitch Williams (6) | Fifth | 6 out |
| Friday, May 22 |
| » Defeated Cardinals (23-18), 3-1 | Busch Stadium II (1-0) | 18-23 | |
| » W: Mark Portugal (4-1) L: Jose DeLeon (2-3) S: Doug Jones (9) | Fifth | 6½ out |
| Saturday, May 23 |
| » Lost to Cardinals (24-18), 10-4 | Busch Stadium II (1-1) | 18-24 | |
| » W: Donovan Osborne (5-2) L: Pete Harnisch (2-5) S: Cris Carpenter (1) | Fifth | 6½ out |
| Sunday, May 24 |
| » Lost to Cardinals (25-18), 4-3 | Busch Stadium II (1-2) | 18-25 | Lost 2 |
| » W: Lee Smith (1-1) L: Al Osuna (3-2) | Sixth | 6½ out |
| Monday, May 25 |
| » Defeated Expos (19-22), 10-8 | Stade Olympique (1-0) | 19-25 | |
| » W: Butch Henry (1-4) L: Chris Haney (2-3) S: Doug Jones (10) | Fifth | 6 out |
| Tuesday, May 26 |
| » Defeated Expos (19-23), 9-4 | Stade Olympique (2-0) | 20-25 | Won 2 |
| » W: Joe Boever (1-1) L: Chris Nabholz (2-4) S: Doug Jones (11) | Fourth | 6 out |
| Wednesday, May 27 |
| » Lost to Expos (20-23), 8-5 | Stade Olympique (2-1) | 20-26 | |
| » W: Dennis Martinez (5-4) L: Mark Portugal (4-2) S: John Wetteland (8) | Sixth | 7 out |
| Friday, May 29 |
| » Lost to Phillies (21-24), 2-1 | Astrodome (14-13) | 20-27 | Lost 2 |
| » W: Barry Jones (2-2) L: Al Osuna (3-3) | Sixth | 6½ out |
| Saturday, May 30 |
| » Defeated Phillies (21-25), 5-4 | Astrodome (15-13) | 21-27 | |
| » W: Jimmy Jones (2-0) L: Terry Mulholland (5-4) S: Doug Jones (12) | Sixth | 6 out |
| Sunday, May 31 |
| » Lost to Phillies (22-25), 6-3 | Astrodome (15-14) | 21-28 | |
| » W: Barry Jones (3-2) L: Rob Murphy (0-1) S: Wally Ritchie (1) | Sixth | 6½ out |
| Monday, June 1 |
| » Lost to Expos (22-25), 7-1 | Astrodome (15-15) | 21-29 | Lost 2 |
| » W: Dennis Martinez (6-4) L: Darryl Kile (2-6) | Sixth | 6½ out |
| Tuesday, June 2 |
| » Defeated Expos (22-26), 6-0 | Astrodome (16-15) | 22-29 | |
| » W: Mark Portugal (5-2) L: Bill Sampen (0-3) | Sixth | 6½ out |
| Wednesday, June 3 |
| » Defeated Expos (22-27), 5-3 | Astrodome (17-15) | 23-29 | Won 2 |
| » W: Pete Harnisch (3-5) L: Ken Hill (4-3) S: Doug Jones (13) | Sixth | 6½ out |
| Thursday, June 4 |
| » Defeated Giants (27-24), 12-6 | Candlestick Park (1-0) | 24-29 | Won 3 |
| » W: Jimmy Jones (3-0) L: Gil Heredia (2-1) | Sixth | 5½ out |
| Friday, June 5 |
| » Defeated Giants (27-25), 5-4 | Candlestick Park (2-0) | 25-29 | Won 4 |
| » W: Xavier Hernandez (4-0) L: Jeff Brantley (2-3) S: Doug Jones (14) | Sixth | 5½ out |
| Saturday, June 6 |
| » Lost to Giants (28-25), 12-6 | Candlestick Park (2-1) | 25-30 | |
| » W: Dave Righetti (1-3) L: Joe Boever (1-2) | Sixth | 6½ out |
| Sunday, June 7 |
| » Lost to Giants (29-25), 3-0 | Candlestick Park (2-2) | 25-31 | Lost 2 |
| » W: Trevor Wilson (5-5) L: Mark Portugal (5-3) | Sixth | 6½ out |
| Monday, June 8 |
| » Lost to Padres (30-27), 3-2 | San Diego/Jack Murphy Stadium (0-1) | 25-32 | Lost 3 |
| » W: Bruce Hurst (6-4) L: Pete Harnisch (3-6) | Sixth | 7½ out |
| Tuesday, June 9 |
| » Lost to Padres (31-27), 5-4 | San Diego/Jack Murphy Stadium (0-2) | 25-33 | Lost 4 |
| » W: Pat Clements (2-0) L: Joe Boever (1-3) S: Mike Maddux (1) | Sixth | 8½ out |
| Wednesday, June 10 |
| » Lost to Padres (32-27), 5-1 | San Diego/Jack Murphy Stadium (0-3) | 25-34 | Lost 5 |
| » W: Craig Lefferts (7-4) L: Butch Henry (1-5) | Sixth | 8½ out |
| Friday, June 12 |
| » Lost to Giants (31-27), 3-2 | Astrodome (17-16) | 25-35 | Lost 6 |
| » W: Mike Jackson (2-1) L: Doug Jones (3-4) S: Rod Beck (3) | Sixth | 9½ out |
| Saturday, June 13 |
| » Defeated Giants (31-28), 4-1 | Astrodome (18-16) | 26-35 | |
| » W: Xavier Hernandez (5-0) L: Jeff Brantley (2-4) S: Doug Jones (15) | Fifth | 9½ out |
| Sunday, June 14 |
| » Defeated Giants (31-29), 15-7 | Astrodome (19-16) | 27-35 | Won 2 |
| » W: Rob Murphy (1-1) L: Dave Righetti (1-4) | Sixth | 9½ out |
| » Major-league debuts: Eddie Tucker (Astros) |
| Monday, June 15 |
| » Lost to Padres (33-30), 7-1 | Astrodome (19-17) | 27-36 | |
| » W: Craig Lefferts (8-4) L: Butch Henry (1-6) | Sixth | 10½ out |
| Tuesday, June 16 |
| » Defeated Padres (33-31), 11-0 | Astrodome (20-17) | 28-36 | |
| » W: Brian Williams (1-0) L: Rich Rodriguez (3-2) S: Xavier Hernandez (1) | Fifth | 10½ out |
| Wednesday, June 17 |
| » Lost to Padres (34-31), 5-0 | Astrodome (20-18) | 28-37 | |
| » W: Andy Benes (6-5) L: Willie Blair (0-1) | Fifth | 11½ out |
| Friday, June 19 |
| » Defeated Dodgers (26-36), 2-1 | Astrodome (21-18) | 29-37 | |
| » W: Joe Boever (2-3) L: Jim Gott (1-2) | Fifth | 11 out |
| Saturday, June 20 |
| » Defeated Dodgers (26-37), 1-0 | Astrodome (22-18) | 30-37 | Won 2 |
| » W: Doug Jones (4-4) L: Orel Hershiser (6-5) | Fifth | 10 out |
| Sunday, June 21 |
| » Defeated Dodgers (26-38), 2-0 | Astrodome (23-18) | 31-37 | Won 3 |
| » W: Butch Henry (2-6) L: Kevin Gross (3-7) S: Doug Jones (16) | Fifth | 9 out |
| Monday, June 22 |
| » Defeated Reds (39-28), 5-2 | Riverfront Stadium (1-0) | 32-37 | Won 4 |
| » W: Brian Williams (2-0) L: Chris Hammond (5-3) S: Xavier Hernandez (2) | Fifth | 8 out |
| » Major-league debuts: Tony Menendez (Reds) |
| Tuesday, June 23 |
| » Lost to Reds (40-28), 10-6 | Riverfront Stadium (1-1) | 32-38 | |
| » W: Tim Belcher (7-6) L: Willie Blair (0-2) | Fifth | 9 out |
| Wednesday, June 24 |
| » Lost to Reds (41-28), 9-6 | Riverfront Stadium (1-2) | 32-39 | Lost 2 |
| » W: Greg Swindell (7-2) L: Pete Harnisch (3-7) S: Norm Charlton (17) | Fifth | 10 out |
| Thursday, June 25 |
| » Lost to Dodgers (28-39), 8-5 | Dodger Stadium (0-1) | 32-40 | Lost 3 |
| » W: Ramon Martinez (4-4) L: Jimmy Jones (3-1) | Fifth | 10½ out |
| Friday, June 26 |
| » Lost to Dodgers (29-39), 6-5 | Dodger Stadium (0-2) | 32-41 | Lost 4 |
| » W: John Candelaria (1-1) L: Doug Jones (4-5) S: Roger McDowell (10) | Fifth | 11½ out |
| Saturday, June 27 |
| » Defeated Dodgers (29-40), 5-1 | Dodger Stadium (1-2) | 33-41 | |
| » W: Brian Williams (3-0) L: Kevin Gross (3-8) | Fifth | 11½ out |
| Sunday, June 28 |
| » Lost to Dodgers (30-40), 8-2 | Dodger Stadium (1-3) | 33-42 | |
| » W: Bob Ojeda (4-4) L: Willie Blair (0-3) | Fifth | 12½ out |
| Monday, June 29 |
| » Defeated Reds (44-29), 4-3 | Astrodome (24-18) | 34-42 | |
| » W: Al Osuna (4-3) L: Rob Dibble (0-3) S: Doug Jones (17) | Fifth | 11½ out |
| Tuesday, June 30 |
| » Defeated Reds (44-30), 5-1 | Astrodome (25-18) | 35-42 | Won 2 |
| » W: Jimmy Jones (4-1) L: Chris Hammond (5-4) S: Xavier Hernandez (3) | Fifth | 10½ out |
| Wednesday, July 1 |
| » Defeated Reds (44-31), 3-2 | Astrodome (26-18) | 36-42 | Won 3 |
| » W: Doug Jones (5-5) L: Scott Bankhead (8-2) | Fifth | 9½ out |
| Saturday, July 4 |
| » Lost to Mets (38-41), 5-3 | Shea Stadium (0-4) | 36-43 | |
| » W: Dwight Gooden (6-7) L: Willie Blair (0-4) S: Jeff Innis (1) | Fifth | 11 out |
| » Defeated Mets (38-42), 3-1 | Shea Stadium (1-4) | 37-43 | |
| » W: Al Osuna (5-3) L: Anthony Young (2-9) S: Doug Jones (18) | Fifth | 11 out |
| Sunday, July 5 |
| » Defeated Mets (38-43), 2-0 | Shea Stadium (2-4) | 38-43 | Won 2 |
| » W: Rob Murphy (2-1) L: Jeff Innis (4-5) S: Doug Jones (19) | Fourth | 11 out |
| Monday, July 6 |
| » Lost to Pirates (45-37), 1-0 | Three Rivers Stadium (1-3) | 38-44 | |
| » W: Zane Smith (7-7) L: Jimmy Jones (4-2) S: Stan Belinda (12) | Fifth | 12 out |
| Tuesday, July 7 |
| » Lost to Pirates (46-37), 5-3 | Three Rivers Stadium (1-4) | 38-45 | Lost 2 |
| » W: Bob Walk (2-3) L: Joe Boever (2-4) | Fifth | 13 out |
| Wednesday, July 8 |
| » Defeated Pirates (46-38), 3-2 | Three Rivers Stadium (2-4) | 39-45 | |
| » W: Doug Jones (6-5) L: Bob Patterson (4-1) | Fifth | 12 out |
| Thursday, July 9 |
| » Defeated Mets (40-45), 4-0 | Astrodome (27-18) | 40-45 | Won 2 |
| » W: Willie Blair (1-4) L: Dwight Gooden (6-8) | Fifth | 12 out |
| Friday, July 10 |
| » Lost to Mets (41-45), 7-6 | Astrodome (27-19) | 40-46 | |
| » W: Jeff Innis (5-5) L: Doug Jones (6-6) S: Anthony Young (3) | Fifth | 12 out |
| » Major-league debuts: Pat Howell (Mets) |
| Saturday, July 11 |
| » Lost to Mets (42-45), 8-2 | Astrodome (27-20) | 40-47 | Lost 2 |
| » W: David Cone (9-4) L: Jimmy Jones (4-3) | Fifth | 12 out |
| Sunday, July 12 |
| » Defeated Mets (42-46), 3-1 | Astrodome (28-20) | 41-47 | |
| » W: Butch Henry (3-6) L: Sid Fernandez (7-8) S: Xavier Hernandez (4) | Fifth | 11 out |
| Thursday, July 16 |
| » Lost to Braves (50-37), 4-2 | Astrodome (28-21) | 41-48 | |
| » W: Steve Avery (8-7) L: Brian Williams (3-1) S: Alejandro Pena (8) | Fifth | 11 out |
| Friday, July 17 |
| » Lost to Braves (51-37), 5-0 | Astrodome (28-22) | 41-49 | Lost 2 |
| » W: John Smoltz (11-6) L: Pete Harnisch (3-8) | Fifth | 12 out |
| Saturday, July 18 |
| » Lost to Braves (52-37), 3-0 | Astrodome (28-23) | 41-50 | Lost 3 |
| » W: Tom Glavine (14-3) L: Jimmy Jones (4-4) S: Alejandro Pena (9) | Fifth | 13 out |
| Sunday, July 19 |
| » Lost to Braves (53-37), 3-2 | Astrodome (28-24) | 41-51 | Lost 4 |
| » W: Marvin Freeman (3-3) L: Xavier Hernandez (5-1) S: Alejandro Pena (10) | Fifth | 14 out |
| Monday, July 20 |
| » Defeated Pirates (51-42), 11-8 | Astrodome (29-24) | 42-51 | |
| » W: Willie Blair (2-4) L: Roger Mason (2-5) S: Doug Jones (20) | Fifth | 14 out |
| » Major-league debuts: Shane Reynolds (Astros) |
| Tuesday, July 21 |
| » Defeated Pirates (51-43), 4-3 | Astrodome (30-24) | 43-51 | Won 2 |
| » W: Doug Jones (7-6) L: Roger Mason (2-6) | Fifth | 13 out |
| Wednesday, July 22 |
| » Lost to Pirates (52-43), 10-7 | Astrodome (30-25) | 43-52 | |
| » W: Stan Belinda (4-2) L: Willie Blair (2-5) S: Bob Patterson (6) | Fifth | 13½ out |
| Friday, July 24 |
| » Lost to Cubs (45-50), 1-0 | Astrodome (30-26) | 43-53 | Lost 2 |
| » W: Mike Morgan (8-4) L: Doug Jones (7-7) S: Bob Scanlan (6) | Fifth | 14½ out |
| Saturday, July 25 |
| » Defeated Cubs (45-51), 3-2 | Astrodome (31-26) | 44-53 | |
| » W: Xavier Hernandez (6-1) L: Chuck McElroy (3-6) | Fifth | 14½ out |
| Sunday, July 26 |
| » Lost to Cubs (46-51), 8-5 | Astrodome (31-27) | 44-54 | |
| » W: Mike Harkey (1-0) L: Shane Reynolds (0-1) | Fifth | 14½ out |
| Monday, July 27 |
| » Defeated Braves (57-39), 5-1 | Atlanta-Fulton County Stadium (2-2) | 45-54 | |
| » W: Doug Jones (8-7) L: Alejandro Pena (1-5) | Fifth | 13½ out |
| Tuesday, July 28 |
| » Defeated Braves (57-40), 7-5 | Atlanta-Fulton County Stadium (3-2) | 46-54 | Won 2 |
| » W: Pete Harnisch (4-8) L: Marvin Freeman (3-4) S: Doug Jones (21) | Fifth | 12½ out |
| Wednesday, July 29 |
| » Lost to Braves (58-40), 5-3 | Atlanta-Fulton County Stadium (3-3) | 46-55 | |
| » W: Tom Glavine (16-3) L: Willie Blair (2-6) S: Alejandro Pena (12) | Fifth | 13½ out |
| Friday, July 31 |
| » Lost to Reds (59-42), 6-1 | Riverfront Stadium (1-3) | 46-56 | Lost 2 |
| » W: Tim Belcher (9-9) L: Butch Henry (3-7) | Fifth | 13½ out |
| Saturday, August 1 |
| » Lost to Reds (60-42), 9-0 | Riverfront Stadium (1-4) | 46-57 | Lost 3 |
| » W: Greg Swindell (10-4) L: Brian Williams (3-2) | Fifth | 14½ out |
| Sunday, August 2 |
| » Defeated Reds (60-43), 5-4 | Riverfront Stadium (2-4) | 47-57 | |
| » W: Joe Boever (3-4) L: Jose Rijo (8-8) S: Doug Jones (22) | Fifth | 14½ out |
| Monday, August 3 |
| » Lost to Reds (61-43), 4-0 | Riverfront Stadium (2-5) | 47-58 | |
| » W: Chris Hammond (6-6) L: Jimmy Jones (4-5) | Fifth | 15 out |
| Tuesday, August 4 |
| » Lost to Dodgers (46-60), 7-2 | Dodger Stadium (1-4) | 47-59 | Lost 2 |
| » W: Ramon Martinez (7-8) L: Shane Reynolds (0-2) | Fifth | 16 out |
| Wednesday, August 5 |
| » Defeated Dodgers (46-61), 7-6 | Dodger Stadium (2-4) | 48-59 | |
| » W: Rob Murphy (3-1) L: Roger McDowell (4-8) S: Doug Jones (23) | Fifth | 16 out |
| Thursday, August 6 |
| » Lost to Padres (59-51), 7-5 | San Diego/Jack Murphy Stadium (0-4) | 48-60 | |
| » W: Andy Benes (9-10) L: Brian Williams (3-3) S: Randy Myers (23) | Fifth | 17 out |
| Friday, August 7 |
| » Lost to Padres (60-51), 4-2 | San Diego/Jack Murphy Stadium (0-5) | 48-61 | Lost 2 |
| » W: Jim Deshaies (2-2) L: Pete Harnisch (4-9) S: Randy Myers (24) | Fifth | 18 out |
| Saturday, August 8 |
| » Lost to Padres (61-51), 7-5 | San Diego/Jack Murphy Stadium (0-6) | 48-62 | Lost 3 |
| » W: Rich Rodriguez (6-2) L: Joe Boever (3-5) S: Larry Andersen (2) | Fifth | 19 out |
| Sunday, August 9 |
| » Lost to Padres (62-51), 4-3 | San Diego/Jack Murphy Stadium (0-7) | 48-63 | Lost 4 |
| » W: Larry Andersen (1-0) L: Doug Jones (8-8) S: Randy Myers (25) | Fifth | 20 out |
| Monday, August 10 |
| » Lost to Giants (53-59), 4-1 | Candlestick Park (2-3) | 48-64 | Lost 5 |
| » W: John Burkett (9-6) L: Butch Henry (3-8) | Fifth | 20 out |
| Tuesday, August 11 |
| » Defeated Giants (53-60), 6-3 | Candlestick Park (3-3) | 49-64 | |
| » W: Brian Williams (4-3) L: Francisco Oliveras (0-1) S: Doug Jones (24) | Fifth | 19 out |
| Wednesday, August 12 |
| » Defeated Giants (53-61), 5-4 | Candlestick Park (4-3) | 50-64 | Won 2 |
| » W: Xavier Hernandez (7-1) L: Jeff Brantley (3-6) S: Doug Jones (25) | Fifth | 18½ out |
| Thursday, August 13 |
| » Defeated Cubs (55-59), 4-3 | Wrigley Field (1-2) | 51-64 | Won 3 |
| » W: Jimmy Jones (5-5) L: Frank Castillo (6-9) S: Doug Jones (26) | Fifth | 18½ out |
| Friday, August 14 |
| » Lost to Cubs (56-59), 4-2 | Wrigley Field (1-3) | 51-65 | |
| » W: Mike Harkey (3-0) L: Darryl Kile (2-7) S: Paul Assenmacher (7) | Fifth | 19½ out |
| Saturday, August 15 |
| » Defeated Cubs (56-60), 5-0 | Wrigley Field (2-3) | 52-65 | |
| » W: Butch Henry (4-8) L: Jim Bullinger (1-3) | Fifth | 19½ out |
| Sunday, August 16 |
| » Lost to Cubs (57-60), 1-0 | Wrigley Field (2-4) | 52-66 | |
| » W: Greg Maddux (15-9) L: Brian Williams (4-4) | Fifth | 19½ out |
| Tuesday, August 18 |
| » Defeated Cardinals (55-62), 7-6 | Busch Stadium II (2-2) | 53-66 | |
| » W: Jimmy Jones (6-5) L: Omar Olivares (6-8) S: Doug Jones (27) | Fifth | 20 out |
| Wednesday, August 19 |
| » Lost to Cardinals (56-62), 12-1 | Busch Stadium II (2-3) | 53-67 | |
| » W: Rheal Cormier (4-10) L: Darryl Kile (2-8) | Fifth | 21 out |
| Thursday, August 20 |
| » Lost to Cardinals (57-62), 3-1 | Busch Stadium II (2-4) | 53-68 | Lost 2 |
| » W: Bob Tewksbury (13-5) L: Butch Henry (4-9) S: Lee Smith (31) | Fifth | 21 out |
| Friday, August 21 |
| » Defeated Phillies (51-69), 6-1 | Veteran's Stadium (2-2) | 54-68 | |
| » W: Brian Williams (5-4) L: Andy Ashby (1-1) | Fifth | 20 out |
| Saturday, August 22 |
| » Defeated Phillies (51-70), 14-9 | Veteran's Stadium (3-2) | 55-68 | Won 2 |
| » W: Willie Blair (3-6) L: Mike Hartley (5-5) | Fifth | 20 out |
| Sunday, August 23 |
| » Defeated Phillies (51-71), 3-1 | Veteran's Stadium (4-2) | 56-68 | Won 3 |
| » W: Jimmy Jones (7-5) L: Curt Schilling (11-8) S: Doug Jones (28) | Fifth | 19 out |
| Monday, August 24 |
| » Major-league debuts: Todd Revenig (Athletics) |
| Tuesday, August 25 |
| » Lost to Cardinals (60-63), 5-3 | Astrodome (31-28) | 56-69 | |
| » W: Cris Carpenter (4-4) L: Joe Boever (3-6) S: Lee Smith (33) | Fifth | 19 out |
| Wednesday, August 26 |
| » Defeated Cardinals (60-64), 6-5 | Astrodome (32-28) | 57-69 | |
| » W: Xavier Hernandez (8-1) L: Mike Perez (7-3) | Fifth | 18 out |
| Thursday, August 27 |
| » Defeated Cardinals (60-65), 5-1 | Astrodome (33-28) | 58-69 | Won 2 |
| » W: Brian Williams (6-4) L: Donovan Osborne (9-7) | Fifth | 17½ out |
| Friday, August 28 |
| » Defeated Expos (69-58), 8-1 | Astrodome (34-28) | 59-69 | Won 3 |
| » W: Pete Harnisch (5-9) L: Mark Gardner (11-9) | Fourth | 16½ out |
| Saturday, August 29 |
| » Defeated Expos (69-59), 8-2 | Astrodome (35-28) | 60-69 | Won 4 |
| » W: Jimmy Jones (8-5) L: Brian Barnes (4-5) | Fourth | 16½ out |
| Sunday, August 30 |
| » Lost to Expos (70-59), 4-0 | Astrodome (35-29) | 60-70 | |
| » W: Ken Hill (14-7) L: Darryl Kile (2-9) | Fourth | 16½ out |
| Monday, August 31 |
| » Defeated Phillies (53-76), 9-2 | Astrodome (36-29) | 61-70 | |
| » W: Butch Henry (5-9) L: Andy Ashby (1-3) | Fourth | 17 out |
| Tuesday, September 1 |
| » Defeated Phillies (53-77), 5-3 | Astrodome (37-29) | 62-70 | Won 2 |
| » W: Brian Williams (7-4) L: Cliff Brantley (2-6) S: Doug Jones (29) | Fourth | 17 out |
| Wednesday, September 2 |
| » Defeated Phillies (53-78), 3-2 | Astrodome (38-29) | 63-70 | Won 3 |
| » W: Pete Harnisch (6-9) L: Terry Mulholland (12-9) S: Doug Jones (30) | Fourth | 16 out |
| Friday, September 4 |
| » Lost to Expos (75-59), 5-2 | Stade Olympique (2-2) | 63-71 | |
| » W: Ken Hill (15-7) L: Jimmy Jones (8-6) S: John Wetteland (32) | Fourth | 15½ out |
| Saturday, September 5 |
| » Defeated Expos (75-60), 5-2 | Stade Olympique (3-2) | 64-71 | |
| » W: Darryl Kile (3-9) L: Chris Nabholz (9-10) | Fourth | 15½ out |
| Former Astro Ron Davis dies in Houston, TX at the age of 51. |
| Sunday, September 6 |
| » Defeated Expos (75-61), 3-1 | Stade Olympique (4-2) | 65-71 | Won 2 |
| » W: Butch Henry (6-9) L: Dennis Martinez (15-11) S: Doug Jones (31) | Fourth | 15½ out |
| Monday, September 7 |
| » Lost to Reds (75-62), 10-0 | Astrodome (38-30) | 65-72 | |
| » W: Jose Rijo (11-9) L: Brian Williams (7-5) | Fourth | 16½ out |
| » Major-league debuts: Dan Wilson (Reds) |
| Tuesday, September 8 |
| » Defeated Reds (75-63), 2-0 | Astrodome (39-30) | 66-72 | |
| » W: Pete Harnisch (7-9) L: Chris Hammond (7-10) S: Xavier Hernandez (5) | Fourth | 16½ out |
| Wednesday, September 9 |
| » Defeated Giants (61-78), 6-4 | Candlestick Park (5-3) | 67-72 | Won 2 |
| » W: Willie Blair (4-6) L: Bill Swift (9-4) S: Xavier Hernandez (6) | Fourth | 16½ out |
| Thursday, September 10 |
| » Lost to Giants (62-78), 5-2 | Candlestick Park (5-4) | 67-73 | |
| » W: John Burkett (12-9) L: Ryan Bowen (0-5) S: Rod Beck (14) | Fourth | 17½ out |
| Friday, September 11 |
| » Lost to Braves (85-55), 7-0 | Astrodome (39-31) | 67-74 | Lost 2 |
| » W: Pete Smith (5-0) L: Darryl Kile (3-10) | Fourth | 18½ out |
| » Major-league debuts: Rich Scheid (Astros) |
| Saturday, September 12 |
| » Lost to Braves (86-55), 9-3 | Astrodome (39-32) | 67-75 | Lost 3 |
| » W: David Nied (2-0) L: Brian Williams (7-6) | Fourth | 19½ out |
| » Major-league debuts: Ryan Klesko (Braves) |
| Sunday, September 13 |
| » Lost to Braves (87-55), 9-2 | Astrodome (39-33) | 67-76 | Lost 4 |
| » W: Charlie Leibrandt (12-6) L: Pete Harnisch (7-10) | Fourth | 20½ out |
| Monday, September 14 |
| » Defeated Giants (64-80), 5-0 | Astrodome (40-33) | 68-76 | |
| » W: Willie Blair (5-6) L: Kevin Rogers (0-1) S: Xavier Hernandez (7) | Fourth | 20 out |
| Tuesday, September 15 |
| » Defeated Giants (64-81), 9-6 | Astrodome (41-33) | 69-76 | Won 2 |
| » W: Doug Jones (9-8) L: Dave Righetti (1-7) | Fourth | 19 out |
| Wednesday, September 16 |
| » Defeated Giants (64-82), 3-1 | Astrodome (42-33) | 70-76 | Won 3 |
| » W: Darryl Kile (4-10) L: Larry Carter (1-2) S: Joe Boever (2) | Fourth | 19 out |
| Friday, September 18 |
| » Defeated Braves (88-58), 13-3 | Atlanta-Fulton County Stadium (4-3) | 71-76 | Won 4 |
| » W: Pete Harnisch (8-10) L: Charlie Leibrandt (12-7) | Fourth | 17½ out |
| » Major-league debuts: Javy Lopez (Braves) |
| Saturday, September 19 |
| » Defeated Braves (88-59), 3-2 | Atlanta-Fulton County Stadium (5-3) | 72-76 | Won 5 |
| » W: Doug Jones (10-8) L: Marvin Freeman (6-5) | Fourth | 16½ out |
| Sunday, September 20 |
| » Lost to Braves (89-59), 16-1 | Atlanta-Fulton County Stadium (5-4) | 72-77 | |
| » W: Steve Avery (11-10) L: Ryan Bowen (0-6) | Fourth | 17½ out |
| Tuesday, September 22 |
| » Lost to Reds (83-67), 6-3 | Riverfront Stadium (2-6) | 72-78 | Lost 2 |
| » W: Jose Rijo (14-9) L: Rich Scheid (0-1) | |