| Monday, April 8 |
| » Major-league debuts: Mike Timlin (Blue Jays) |
| Tuesday, April 9 |
| » Lost to Athletics (1-0), 7-2 | Oakland-Alameda County Stadium (0-1) | 0-1 | |
| » W: Dave Stewart (1-0) L: Jack Morris (0-1) | Third | 1 out |
| » Major-league debuts: Dana Allison (Athletics) Chuck Knoblauch (Twins) |
| Wednesday, April 10 |
| » Defeated Athletics (1-1), 4-1 | Oakland-Alameda County Stadium (1-1) | 1-1 | |
| » W: Allan Anderson (1-0) L: Bob Welch (0-1) S: Rick Aguilera (1) | Third | 1 out |
| Thursday, April 11 |
| » Lost to Athletics (2-1), 3-0 | Oakland-Alameda County Stadium (1-2) | 1-2 | |
| » W: Joe Slusarski (1-0) L: Scott Erickson (0-1) S: Dennis Eckersley (1) | Fourth | 2 out |
| » Major-league debuts: Joe Slusarski (Athletics) |
| Friday, April 12 |
| » Defeated Angels (3-1), 6-0 | Hubert H. Humphrey Metrodome (1-0) | 2-2 | |
| » W: Kevin Tapani (1-0) L: Jim Abbott (0-1) | Third | 1½ out |
| Saturday, April 13 |
| » Lost to Angels (4-1), 15-9 | Hubert H. Humphrey Metrodome (1-1) | 2-3 | |
| » W: Scott Bailes (1-0) L: Mark Guthrie (0-1) | Fourth | 2½ out |
| Sunday, April 14 |
| » Lost to Angels (5-1), 9-4 | Hubert H. Humphrey Metrodome (1-2) | 2-4 | Lost 2 |
| » W: Chuck Finley (2-0) L: Jack Morris (0-2) | Fourth | 3 out |
| Monday, April 15 |
| » Lost to Mariners (1-6), 8-4 | Kingdome (0-1) | 2-5 | Lost 3 |
| » W: Randy Johnson (1-1) L: Allan Anderson (1-1) | Fifth | 4 out |
| Tuesday, April 16 |
| » Lost to Mariners (2-6), 3-0 | Kingdome (0-2) | 2-6 | Lost 4 |
| » W: Brian Holman (1-1) L: Scott Erickson (0-2) | Sixth | 5 out |
| Wednesday, April 17 |
| » Lost to Mariners (3-6), 4-3 | Kingdome (0-3) | 2-7 | Lost 5 |
| » W: Mike Jackson (1-1) L: Rick Aguilera (0-1) | Seventh | 6 out |
| Thursday, April 18 |
| » Major-league debuts: John Briscoe (Athletics) |
| Friday, April 19 |
| » Lost to Angels (7-4), 2-0 | Anaheim Stadium (0-1) | 2-8 | Lost 6 |
| » W: Chuck Finley (3-0) L: Jack Morris (0-3) | Sixth | 5 out |
| Saturday, April 20 |
| » Lost to Angels (8-4), 2-1 | Anaheim Stadium (0-2) | 2-9 | Lost 7 |
| » W: Kirk McCaskill (2-1) L: Allan Anderson (1-2) S: Bryan Harvey (3) | Fifth | 5½ out |
| Sunday, April 21 |
| » Defeated Angels (8-5), 4-3 | Anaheim Stadium (1-2) | 3-9 | |
| » W: Scott Erickson (1-2) L: Mark Eichhorn (0-1) S: Rick Aguilera (2) | Sixth | 5 out |
| Monday, April 22 |
| » Defeated Athletics (8-6), 3-2 | Hubert H. Humphrey Metrodome (2-2) | 4-9 | Won 2 |
| » W: Steve Bedrosian (1-0) L: Joe Klink (0-1) S: Rick Aguilera (3) | Sixth | 5 out |
| Tuesday, April 23 |
| » Lost to Athletics (9-6), 7-5 | Hubert H. Humphrey Metrodome (2-3) | 4-10 | |
| » W: Kirk Dressendorfer (2-1) L: Mark Guthrie (0-2) S: Dennis Eckersley (5) | Seventh | 6 out |
| Wednesday, April 24 |
| » Defeated Athletics (9-7), 7-4 | Hubert H. Humphrey Metrodome (3-3) | 5-10 | |
| » W: Jack Morris (1-3) L: Dave Stewart (1-2) S: Rick Aguilera (4) | Sixth | 5 out |
| Thursday, April 25 |
| » Defeated Mariners (8-8), 4-3 | Hubert H. Humphrey Metrodome (4-3) | 6-10 | Won 2 |
| » W: Steve Bedrosian (2-0) L: Mike Jackson (1-2) | Sixth | 4½ out |
| Friday, April 26 |
| » Defeated Mariners (8-9), 6-0 | Hubert H. Humphrey Metrodome (5-3) | 7-10 | Won 3 |
| » W: Scott Erickson (2-2) L: Randy Johnson (2-2) | Seventh | 3½ out |
| Saturday, April 27 |
| » Defeated Mariners (8-10), 7-2 | Hubert H. Humphrey Metrodome (6-3) | 8-10 | Won 4 |
| » W: Kevin Tapani (2-0) L: Brian Holman (2-2) | Sixth | 3½ out |
| Sunday, April 28 |
| » Defeated Mariners (8-11), 8-2 | Hubert H. Humphrey Metrodome (7-3) | 9-10 | Won 5 |
| » W: Jack Morris (2-3) L: Scott Bankhead (1-2) | Third | 3½ out |
| Tuesday, April 30 |
| » Lost to Red Sox (11-7), 7-5 | Hubert H. Humphrey Metrodome (7-4) | 9-11 | |
| » W: Jeff Gray (1-1) L: Steve Bedrosian (2-1) S: Jeff Reardon (8) | Sixth | 4 out |
| Wednesday, May 1 |
| » Defeated Red Sox (11-8), 1-0 | Hubert H. Humphrey Metrodome (8-4) | 10-11 | |
| » W: Scott Erickson (3-2) L: Jeff Gray (1-2) | Fourth | 4 out |
| Thursday, May 2 |
| » Lost to Brewers (12-9), 5-1 | County Stadium (0-1) | 10-12 | |
| » W: Kevin Brown (2-0) L: Kevin Tapani (2-1) S: Chuck Crim (3) | Fifth | 4½ out |
| Friday, May 3 |
| » Lost to Brewers (13-9), 6-5 | County Stadium (0-2) | 10-13 | Lost 2 |
| » W: Jaime Navarro (2-0) L: Rick Aguilera (0-2) S: Edwin Nunez (3) | Fifth | 5½ out |
| Saturday, May 4 |
| » Defeated Brewers (13-10), 7-4 | County Stadium (1-2) | 11-13 | |
| » W: Mark Guthrie (1-2) L: Chris Bosio (3-3) S: Steve Bedrosian (1) | Fifth | 4½ out |
| Sunday, May 5 |
| » Defeated Brewers (13-11), 5-2 | County Stadium (2-2) | 12-13 | Won 2 |
| » W: Rick Aguilera (1-2) L: Edwin Nunez (1-1) | Fifth | 3½ out |
| Monday, May 6 |
| » Major-league debuts: Rod Beck (Giants) |
| Tuesday, May 7 |
| » Defeated Red Sox (14-9), 9-3 | Fenway Park (1-0) | 13-13 | Won 3 |
| » W: Scott Erickson (4-2) L: Greg Harris (1-3) | Fifth | 3½ out |
| Wednesday, May 8 |
| » Lost to Red Sox (15-9), 8-3 | Fenway Park (1-1) | 13-14 | |
| » W: Roger Clemens (6-0) L: Jack Morris (2-4) | Fifth | 4½ out |
| Thursday, May 9 |
| » Lost to Tigers (16-10), 3-0 | Hubert H. Humphrey Metrodome (8-5) | 13-15 | Lost 2 |
| » W: Dan Petry (1-1) L: Kevin Tapani (2-2) S: Paul Gibson (3) | Sixth | 5 out |
| Friday, May 10 |
| » Defeated Tigers (16-11), 5-2 | Hubert H. Humphrey Metrodome (9-5) | 14-15 | |
| » W: Mark Guthrie (2-2) L: Walt Terrell (1-4) S: Rick Aguilera (5) | Fifth | 4 out |
| Saturday, May 11 |
| » Defeated Tigers (16-12), 5-4 | Hubert H. Humphrey Metrodome (10-5) | 15-15 | Won 2 |
| » W: Carl Willis (1-0) L: Mike Henneman (3-1) S: Rick Aguilera (6) | Fifth | 4 out |
| Sunday, May 12 |
| » Defeated Tigers (16-13), 8-3 | Hubert H. Humphrey Metrodome (11-5) | 16-15 | Won 3 |
| » W: Scott Erickson (5-2) L: Bill Gullickson (4-1) | Fourth | 3 out |
| Tuesday, May 14 |
| » Defeated Brewers (13-17), 5-1 | Hubert H. Humphrey Metrodome (12-5) | 17-15 | Won 4 |
| » W: Jack Morris (3-4) L: Jaime Navarro (2-2) | Third | 1½ out |
| Wednesday, May 15 |
| » Lost to Brewers (14-17), 4-2 | Hubert H. Humphrey Metrodome (12-6) | 17-16 | |
| » W: Chris Bosio (4-4) L: Kevin Tapani (2-3) S: Dan Plesac (1) | Fourth | 2½ out |
| Thursday, May 16 |
| » Lost to Brewers (15-17), 6-3 | Hubert H. Humphrey Metrodome (12-7) | 17-17 | Lost 2 |
| » W: Bill Wegman (1-1) L: Allan Anderson (1-3) S: Darren Holmes (1) | Sixth | 3½ out |
| Friday, May 17 |
| » Defeated Tigers (16-17), 8-1 | Tiger Stadium (1-0) | 18-17 | |
| » W: Scott Erickson (6-2) L: Bill Gullickson (4-2) S: Steve Bedrosian (2) | Fifth | 3 out |
| Saturday, May 18 |
| » Defeated Tigers (16-18), 4-1 | Tiger Stadium (2-0) | 19-17 | Won 2 |
| » W: Mark Guthrie (3-2) L: Frank Tanana (2-3) S: Rick Aguilera (7) | Fourth | 3 out |
| Sunday, May 19 |
| » Lost to Tigers (17-18), 8-3 | Tiger Stadium (2-1) | 19-18 | |
| » W: Dan Petry (2-2) L: Jack Morris (3-5) | Sixth | 3½ out |
| Tuesday, May 21 |
| » Lost to Rangers (19-14), 6-5 | Hubert H. Humphrey Metrodome (12-8) | 19-19 | Lost 2 |
| » W: Bobby Witt (2-3) L: Kevin Tapani (2-4) S: Jeff Russell (9) | Fifth | 3½ out |
| Wednesday, May 22 |
| » Lost to Rangers (20-14), 5-2 | Hubert H. Humphrey Metrodome (12-9) | 19-20 | Lost 3 |
| » W: Gerald Alexander (2-0) L: Carl Willis (1-1) S: Jeff Russell (10) | Sixth | 4 out |
| Thursday, May 23 |
| » Lost to Rangers (21-14), 10-6 | Hubert H. Humphrey Metrodome (12-10) | 19-21 | Lost 4 |
| » W: Jeff Russell (1-0) L: Steve Bedrosian (2-2) | Fifth | 4½ out |
| Friday, May 24 |
| » Defeated Royals (16-23), 3-2 | Hubert H. Humphrey Metrodome (13-10) | 20-21 | |
| » W: Jack Morris (4-5) L: Storm Davis (2-5) S: Rick Aguilera (8) | Sixth | 4½ out |
| Saturday, May 25 |
| » Lost to Royals (17-23), 11-2 | Hubert H. Humphrey Metrodome (13-11) | 20-22 | |
| » W: Mark Gubicza (1-2) L: Mark Guthrie (3-3) | Fifth | 5½ out |
| Sunday, May 26 |
| » Lost to Royals (18-23), 5-1 | Hubert H. Humphrey Metrodome (13-12) | 20-23 | Lost 2 |
| » W: Bret Saberhagen (5-3) L: Kevin Tapani (2-5) | Sixth | 6½ out |
| Monday, May 27 |
| » Lost to Rangers (25-14), 11-4 | Arlington Stadium (0-1) | 20-24 | Lost 3 |
| » W: Kevin Brown (4-3) L: Allan Anderson (1-4) | Sixth | 7½ out |
| Tuesday, May 28 |
| » Defeated Rangers (25-15), 3-0 | Arlington Stadium (1-1) | 21-24 | |
| » W: Scott Erickson (7-2) L: Jose Guzman (0-1) S: Rick Aguilera (9) | Sixth | 6½ out |
| Wednesday, May 29 |
| » Defeated Rangers (25-16), 9-1 | Arlington Stadium (2-1) | 22-24 | Won 2 |
| » W: Jack Morris (5-5) L: Nolan Ryan (3-4) | Fifth | 5½ out |
| Thursday, May 30 |
| » Defeated Royals (20-25), 4-2 | Royals Stadium (1-0) | 23-24 | Won 3 |
| » W: Mark Guthrie (4-3) L: Mark Gubicza (1-3) S: Rick Aguilera (10) | Fifth | 5½ out |
| Friday, May 31 |
| » Lost to Royals (21-25), 4-1 | Royals Stadium (1-1) | 23-25 | |
| » W: Bret Saberhagen (6-3) L: Kevin Tapani (2-6) | Fifth | 5½ out |
| Saturday, June 1 |
| » Defeated Royals (21-26), 8-4 | Royals Stadium (2-1) | 24-25 | |
| » W: Allan Anderson (2-4) L: Kevin Appier (3-6) | Fifth | 5½ out |
| Sunday, June 2 |
| » Defeated Royals (21-27), 4-1 | Royals Stadium (3-1) | 25-25 | Won 2 |
| » W: Scott Erickson (8-2) L: Tom Gordon (4-3) S: Rick Aguilera (11) | Fifth | 4½ out |
| Monday, June 3 |
| » Defeated Orioles (18-30), 3-2 | Hubert H. Humphrey Metrodome (14-12) | 26-25 | Won 3 |
| » W: Jack Morris (6-5) L: Jeff Robinson (3-5) S: Rick Aguilera (12) | Fifth | 4½ out |
| Tuesday, June 4 |
| » Defeated Orioles (18-31), 4-3 | Hubert H. Humphrey Metrodome (15-12) | 27-25 | Won 4 |
| » W: Carl Willis (2-1) L: Gregg Olson (0-2) | Fifth | 4½ out |
| Wednesday, June 5 |
| » Defeated Orioles (18-32), 4-3 | Hubert H. Humphrey Metrodome (16-12) | 28-25 | Won 5 |
| » W: Kevin Tapani (3-6) L: Jose Mesa (4-6) S: Rick Aguilera (13) | Fifth | 4½ out |
| Friday, June 7 |
| » Defeated Indians (21-30), 2-0 | Hubert H. Humphrey Metrodome (17-12) | 29-25 | Won 6 |
| » W: Allan Anderson (3-4) L: Tom Candiotti (7-3) S: Rick Aguilera (14) | Fourth | 4 out |
| Saturday, June 8 |
| » Defeated Indians (21-31), 2-1 | Hubert H. Humphrey Metrodome (18-12) | 30-25 | Won 7 |
| » W: Scott Erickson (9-2) L: Charles Nagy (2-6) S: Rick Aguilera (15) | Third | 3 out |
| Sunday, June 9 |
| » Defeated Indians (21-32), 9-2 | Hubert H. Humphrey Metrodome (19-12) | 31-25 | Won 8 |
| » W: Jack Morris (7-5) L: Rod Nichols (0-5) | Third | 3 out |
| Monday, June 10 |
| » Defeated Indians (21-33), 8-5 | Hubert H. Humphrey Metrodome (20-12) | 32-25 | Won 9 |
| » W: Paul Abbott (1-0) L: Eric King (4-5) S: Rick Aguilera (16) | Third | 3 out |
| Tuesday, June 11 |
| » Defeated Yankees (25-28), 5-3 | Hubert H. Humphrey Metrodome (21-12) | 33-25 | Won 10 |
| » W: Kevin Tapani (4-6) L: John Habyan (4-2) S: Rick Aguilera (17) | Third | 2 out |
| Wednesday, June 12 |
| » Defeated Yankees (25-29), 6-3 | Hubert H. Humphrey Metrodome (22-12) | 34-25 | Won 11 |
| » W: Allan Anderson (4-4) L: Jeff Johnson (0-2) S: Steve Bedrosian (3) | Second | 2 out |
| Thursday, June 13 |
| » Defeated Yankees (25-30), 10-3 | Hubert H. Humphrey Metrodome (23-12) | 35-25 | Won 12 |
| » W: Scott Erickson (10-2) L: Mike Witt (0-1) | Second | 1½ out |
| Friday, June 14 |
| » Defeated Indians (22-36), 7-0 | Cleveland Stadium (1-0) | 36-25 | Won 13 |
| » W: Jack Morris (8-5) L: Jeff Shaw (0-1) | Second | 1 out |
| Saturday, June 15 |
| » Defeated Indians (22-37), 11-7 | Cleveland Stadium (2-0) | 37-25 | Won 14 |
| » W: Paul Abbott (2-0) L: Jeff Mutis (0-1) | Second | ½ out |
| » Major-league debuts: Jeff Mutis (Indians) |
| Sunday, June 16 |
| » Defeated Indians (22-38), 4-2 | Cleveland Stadium (3-0) | 38-25 | Won 15 |
| » W: Rick Aguilera (2-2) L: Shawn Hillegas (2-1) | First | -- |
| Monday, June 17 |
| » Lost to Orioles (23-38), 6-5 | Memorial Stadium (0-1) | 38-26 | |
| » W: Mark Williamson (1-2) L: Rick Aguilera (2-3) | First | -- |
| Tuesday, June 18 |
| » Defeated Orioles (23-39), 9-2 | Memorial Stadium (1-1) | 39-26 | |
| » W: Scott Erickson (11-2) L: Roy Smith (3-1) S: Carl Willis (1) | First | -- |
| Wednesday, June 19 |
| » Defeated Orioles (23-40), 8-4 | Memorial Stadium (2-1) | 40-26 | Won 2 |
| » W: Jack Morris (9-5) L: Gregg Olson (0-3) | First | -- |
| Friday, June 21 |
| » Defeated Yankees (27-35), 5-4 | Yankee Stadium (1-0) | 41-26 | Won 3 |
| » W: Mark Guthrie (5-3) L: Scott Sanderson (7-3) S: Rick Aguilera (18) | First | -- |
| Saturday, June 22 |
| » Defeated Yankees (27-36), 4-3 | Yankee Stadium (2-0) | 42-26 | Won 4 |
| » W: Kevin Tapani (5-6) L: Wade Taylor (2-2) S: Rick Aguilera (19) | First | -- |
| Sunday, June 23 |
| » Lost to Yankees (28-36), 11-2 | Yankee Stadium (2-1) | 42-27 | |
| » W: Scott Kamieniecki (2-0) L: Allan Anderson (4-5) | First | -- |
| Monday, June 24 |
| » Defeated Yankees (28-37), 5-0 | Yankee Stadium (3-1) | 43-27 | |
| » W: Scott Erickson (12-2) L: Jeff Johnson (1-3) | First | -- |
| Tuesday, June 25 |
| » Defeated Blue Jays (39-32), 8-6 | Hubert H. Humphrey Metrodome (24-12) | 44-27 | Won 2 |
| » W: Jack Morris (10-5) L: Todd Stottlemyre (8-3) S: Rick Aguilera (20) | First | -- |
| Wednesday, June 26 |
| » Lost to Blue Jays (40-32), 5-2 | Hubert H. Humphrey Metrodome (24-13) | 44-28 | |
| » W: David Wells (9-4) L: Mark Guthrie (5-4) S: Tom Henke (13) | First | -- |
| Thursday, June 27 |
| » Lost to Blue Jays (41-32), 1-0 | Hubert H. Humphrey Metrodome (24-14) | 44-29 | Lost 2 |
| » W: Juan Guzman (2-2) L: Kevin Tapani (5-7) S: Tom Henke (14) | First | -- |
| Friday, June 28 |
| » Lost to White Sox (37-34), 4-2 | Hubert H. Humphrey Metrodome (24-15) | 44-30 | Lost 3 |
| » W: Charlie Hough (5-3) L: Allan Anderson (4-6) S: Bobby Thigpen (15) | First | -- |
| Saturday, June 29 |
| » Lost to White Sox (38-34), 8-4 | Hubert H. Humphrey Metrodome (24-16) | 44-31 | Lost 4 |
| » W: Greg Hibbard (6-6) L: Scott Erickson (12-3) | First | -- |
| Sunday, June 30 |
| » Defeated White Sox (38-35), 3-0 | Hubert H. Humphrey Metrodome (25-16) | 45-31 | |
| » W: Jack Morris (11-5) L: Jack McDowell (9-4) | First | -- |
| Monday, July 1 |
| » Lost to White Sox (39-35), 5-4 | Hubert H. Humphrey Metrodome (25-17) | 45-32 | |
| » W: Bobby Thigpen (5-2) L: Carl Willis (2-2) | First | -- |
| Tuesday, July 2 |
| » Lost to Blue Jays (45-33), 4-3 | Skydome (0-1) | 45-33 | Lost 2 |
| » W: Duane Ward (2-3) L: Terry Leach (0-1) | First | -- |
| » Major-league debuts: Jarvis Brown (Twins) |
| Wednesday, July 3 |
| » Lost to Blue Jays (46-33), 4-0 | Skydome (0-2) | 45-34 | Lost 3 |
| » W: Tom Candiotti (8-7) L: Allan Anderson (4-7) | Second | 1 out |
| Thursday, July 4 |
| » Defeated Blue Jays (46-34), 1-0 | Skydome (1-2) | 46-34 | |
| » W: David West (1-0) L: Jimmy Key (10-4) S: Rick Aguilera (21) | First | -- |
| Friday, July 5 |
| » Lost to White Sox (42-36), 4-2 | Comiskey Park II (0-1) | 46-35 | |
| » W: Jack McDowell (10-4) L: Jack Morris (11-6) S: Bobby Thigpen (17) | First | -- |
| Saturday, July 6 |
| » Defeated White Sox (42-37), 5-4 | Comiskey Park II (1-1) | 47-35 | |
| » W: Carl Willis (3-2) L: Scott Radinsky (2-3) S: Rick Aguilera (22) | First | -- |
| Sunday, July 7 |
| » Lost to White Sox (43-37), 4-3 | Comiskey Park II (1-2) | 47-36 | |
| » W: Ken Patterson (3-0) L: Mark Guthrie (5-5) S: Bobby Thigpen (18) | Second | 3 out |
| Thursday, July 11 |
| » Defeated Red Sox (42-39), 7-3 | Hubert H. Humphrey Metrodome (26-17) | 48-36 | |
| » W: Carl Willis (4-2) L: Greg Harris (5-8) | First | -- |
| Friday, July 12 |
| » Defeated Red Sox (42-40), 5-4 | Hubert H. Humphrey Metrodome (27-17) | 49-36 | Won 2 |
| » W: Paul Abbott (3-0) L: Roger Clemens (11-6) S: Rick Aguilera (23) | First | -- |
| Saturday, July 13 |
| » Defeated Red Sox (42-41), 3-1 | Hubert H. Humphrey Metrodome (28-17) | 50-36 | Won 3 |
| » W: Jack Morris (12-6) L: Kevin Morton (1-1) S: Rick Aguilera (24) | First | -- |
| Sunday, July 14 |
| » Lost to Red Sox (43-41), 5-3 | Hubert H. Humphrey Metrodome (28-18) | 50-37 | |
| » W: Joe Hesketh (3-1) L: David West (1-1) S: Jeff Reardon (22) | First | -- |
| Monday, July 15 |
| » Defeated Brewers (38-47), 11-7 | County Stadium (3-2) | 51-37 | |
| » W: Mark Guthrie (6-5) L: Jim Hunter (0-3) S: Steve Bedrosian (4) | First | -- |
| » Major-league debuts: Doug Henry (Brewers) |
| Tuesday, July 16 |
| » Lost to Brewers (39-47), 4-3 | County Stadium (3-3) | 51-38 | |
| » W: Doug Henry (1-0) L: Rick Aguilera (2-4) | First | -- |
| Thursday, July 18 |
| » Defeated Red Sox (45-43), 11-3 | Fenway Park (2-1) | 52-38 | |
| » W: Jack Morris (13-6) L: Kevin Morton (1-2) | First | -- |
| Friday, July 19 |
| » Defeated Red Sox (45-44), 3-2 | Fenway Park (3-1) | 53-38 | Won 2 |
| » W: Steve Bedrosian (3-2) L: Greg Harris (6-9) S: Rick Aguilera (25) | First | -- |
| Saturday, July 20 |
| » Defeated Red Sox (45-45), 5-0 | Fenway Park (4-1) | 54-38 | Won 3 |
| » W: Scott Erickson (13-3) L: Mike Gardiner (3-4) S: Mark Guthrie (1) | First | -- |
| Sunday, July 21 |
| » Defeated Red Sox (45-46), 14-1 | Fenway Park (5-1) | 55-38 | Won 4 |
| » W: Kevin Tapani (6-7) L: Tom Bolton (7-7) | First | -- |
| Monday, July 22 |
| » Major-league debuts: Ryan Bowen (Astros) |
| Tuesday, July 23 |
| » Lost to Tigers (48-44), 6-3 | Tiger Stadium (2-2) | 55-39 | |
| » W: Frank Tanana (7-6) L: Allan Anderson (4-8) S: Mike Henneman (14) | First | -- |
| Wednesday, July 24 |
| » Lost to Tigers (49-44), 6-3 | Tiger Stadium (2-3) | 55-40 | Lost 2 |
| » W: Bill Gullickson (13-5) L: David West (1-2) S: Mike Henneman (15) | First | -- |
| Thursday, July 25 |
| » Defeated Tigers (49-45), 9-3 | Tiger Stadium (3-3) | 56-40 | |
| » W: Scott Erickson (14-3) L: Scott Aldred (0-1) S: Steve Bedrosian (5) | First | -- |
| Friday, July 26 |
| » Defeated Brewers (41-55), 6-3 | Hubert H. Humphrey Metrodome (29-18) | 57-40 | Won 2 |
| » W: Kevin Tapani (7-7) L: Darren Holmes (1-2) S: Rick Aguilera (26) | First | -- |
| Saturday, July 27 |
| » Defeated Brewers (41-56), 7-4 | Hubert H. Humphrey Metrodome (30-18) | 58-40 | Won 3 |
| » W: Carl Willis (5-2) L: Bill Wegman (6-5) | First | -- |
| » Major-league debuts: Denny Neagle (Twins) |
| Sunday, July 28 |
| » Lost to Brewers (42-56), 11-2 | Hubert H. Humphrey Metrodome (30-19) | 58-41 | |
| » W: Jaime Navarro (8-8) L: Jack Morris (13-7) | First | -- |
| Monday, July 29 |
| » Defeated Tigers (50-48), 6-3 | Hubert H. Humphrey Metrodome (31-19) | 59-41 | |
| » W: David West (2-2) L: Bill Gullickson (13-6) S: Rick Aguilera (27) | First | -- |
| Tuesday, July 30 |
| » Defeated Tigers (50-49), 9-7 | Hubert H. Humphrey Metrodome (32-19) | 60-41 | Won 2 |
| » W: Carl Willis (6-2) L: John Cerutti (1-3) | First | -- |
| Wednesday, July 31 |
| » Defeated Yankees (46-51), 12-3 | Yankee Stadium (4-1) | 61-41 | Won 3 |
| » W: Kevin Tapani (8-7) L: Scott Sanderson (10-7) | First | -- |
| » Major-league debuts: Willie Banks (Twins) |
| Thursday, August 1 |
| » Lost to Yankees (47-51), 8-3 | Yankee Stadium (4-2) | 61-42 | |
| » W: Greg Cadaret (4-4) L: Paul Abbott (3-1) | First | -- |
| Friday, August 2 |
| » Lost to Athletics (58-46), 3-1 | Oakland-Alameda County Stadium (1-3) | 61-43 | Lost 2 |
| » W: Bob Welch (9-6) L: Jack Morris (13-8) | First | -- |
| Saturday, August 3 |
| » Defeated Athletics (58-47), 8-6 | Oakland-Alameda County Stadium (2-3) | 62-43 | |
| » W: Steve Bedrosian (4-2) L: Joe Klink (8-3) S: Rick Aguilera (28) | First | -- |
| Sunday, August 4 |
| » Defeated Athletics (58-48), 6-2 | Oakland-Alameda County Stadium (3-3) | 63-43 | Won 2 |
| » W: Scott Erickson (15-3) L: Dave Stewart (8-6) S: Carl Willis (2) | First | -- |
| Monday, August 5 |
| » Defeated Angels (52-53), 7-4 | Anaheim Stadium (2-2) | 64-43 | Won 3 |
| » W: Kevin Tapani (9-7) L: Joe Grahe (1-2) S: Rick Aguilera (29) | First | -- |
| Tuesday, August 6 |
| » Defeated Angels (52-54), 7-4 | Anaheim Stadium (3-2) | 65-43 | Won 4 |
| » W: Willie Banks (1-0) L: Chuck Finley (14-6) | First | -- |
| Wednesday, August 7 |
| » Lost to Angels (53-54), 8-1 | Anaheim Stadium (3-3) | 65-44 | |
| » W: Jim Abbott (10-8) L: Jack Morris (13-9) | First | -- |
| Friday, August 9 |
| » Defeated Mariners (57-52), 5-2 | Kingdome (1-3) | 66-44 | |
| » W: David West (3-2) L: Randy Johnson (10-8) S: Rick Aguilera (30) | First | -- |
| Saturday, August 10 |
| » Lost to Mariners (58-52), 8-0 | Kingdome (1-4) | 66-45 | |
| » W: Erik Hanson (7-5) L: Scott Erickson (15-4) | First | -- |
| Sunday, August 11 |
| » Defeated Mariners (58-53), 5-2 | Kingdome (2-4) | 67-45 | |
| » W: Kevin Tapani (10-7) L: Bill Krueger (9-5) | First | -- |
| Monday, August 12 |
| » Defeated Angels (53-58), 4-3 | Hubert H. Humphrey Metrodome (33-19) | 68-45 | Won 2 |
| » W: Jack Morris (14-9) L: Chris Beasley (0-1) S: Rick Aguilera (31) | First | -- |
| Tuesday, August 13 |
| » Lost to Angels (54-58), 8-3 | Hubert H. Humphrey Metrodome (33-20) | 68-46 | |
| » W: Jim Abbott (11-8) L: Willie Banks (1-1) S: Bryan Harvey (26) | First | -- |
| Wednesday, August 14 |
| » Lost to Angels (55-58), 7-4 | Hubert H. Humphrey Metrodome (33-21) | 68-47 | Lost 2 |
| » W: Kirk McCaskill (9-15) L: David West (3-3) S: Bryan Harvey (27) | First | -- |
| Thursday, August 15 |
| » Lost to Angels (56-58), 9-1 | Hubert H. Humphrey Metrodome (33-22) | 68-48 | Lost 3 |
| » W: Mark Langston (15-6) L: Scott Erickson (15-5) | First | -- |
| » Major-league debuts: Chris Cron (Angels) |
| Friday, August 16 |
| » Defeated Athletics (64-53), 5-4 | Hubert H. Humphrey Metrodome (34-22) | 69-48 | |
| » W: Rick Aguilera (3-4) L: Gene Nelson (1-4) | First | -- |
| Saturday, August 17 |
| » Defeated Athletics (64-54), 12-4 | Hubert H. Humphrey Metrodome (35-22) | 70-48 | Won 2 |
| » W: Jack Morris (15-9) L: Bob Welch (10-8) | First | -- |
| Sunday, August 18 |
| » Defeated Athletics (64-55), 6-4 | Hubert H. Humphrey Metrodome (36-22) | 71-48 | Won 3 |
| » W: Carl Willis (7-2) L: Rick Honeycutt (2-3) S: Rick Aguilera (32) | First | -- |
| Monday, August 19 |
| » Lost to Athletics (65-55), 8-7 | Hubert H. Humphrey Metrodome (36-23) | 71-49 | |
| » W: Joe Klink (9-3) L: Steve Bedrosian (4-3) S: Dennis Eckersley (34) | First | -- |
| Tuesday, August 20 |
| » Defeated Mariners (64-56), 10-5 | Hubert H. Humphrey Metrodome (37-23) | 72-49 | |
| » W: Scott Erickson (16-5) L: Erik Hanson (7-6) S: Mark Guthrie (2) | First | -- |
| Wednesday, August 21 |
| » Defeated Mariners (64-57), 9-1 | Hubert H. Humphrey Metrodome (38-23) | 73-49 | Won 2 |
| » W: Kevin Tapani (11-7) L: Bill Krueger (10-6) | First | -- |
| Thursday, August 22 |
| » Defeated Mariners (64-58), 5-4 | Hubert H. Humphrey Metrodome (39-23) | 74-49 | Won 3 |
| » W: Rick Aguilera (4-4) L: Mike Schooler (0-1) | First | -- |
| Friday, August 23 |
| » Lost to Orioles (51-71), 5-4 | Memorial Stadium (2-2) | 74-50 | |
| » W: Gregg Olson (3-4) L: Carl Willis (7-3) | First | -- |
| Saturday, August 24 |
| » Defeated Orioles (51-72), 5-2 | Memorial Stadium (3-2) | 75-50 | |
| » W: Steve Bedrosian (5-3) L: Mike Flanagan (2-5) S: Rick Aguilera (33) | First | -- |
| Sunday, August 25 |
| » Lost to Orioles (52-72), 7-3 | Memorial Stadium (3-3) | 75-51 | |
| » W: Mike Mussina (2-3) L: Scott Erickson (16-6) S: Todd Frohwirth (2) | First | -- |
| Monday, August 26 |
| » Defeated Indians (41-83), 5-3 | Cleveland Stadium (4-0) | 76-51 | |
| » W: Kevin Tapani (12-7) L: Dave Otto (1-4) S: Rick Aguilera (34) | First | -- |
| Tuesday, August 27 |
| » Lost to Indians (42-83), 2-1 | Cleveland Stadium (4-1) | 76-52 | |
| » W: Greg Swindell (8-12) L: Jack Morris (15-10) S: Steve Olin (8) | First | -- |
| Wednesday, August 28 |
| » Defeated Indians (42-84), 4-2 | Cleveland Stadium (5-1) | 77-52 | |
| » W: David West (4-3) L: Eric King (5-8) S: Rick Aguilera (35) | First | -- |
| Friday, August 30 |
| » Lost to Orioles (53-75), 11-5 | Hubert H. Humphrey Metrodome (39-24) | 77-53 | |
| » W: Bob Milacki (8-7) L: Tom Edens (0-1) | First | -- |
| Saturday, August 31 |
| » Defeated Orioles (53-76), 5-2 | Hubert H. Humphrey Metrodome (40-24) | 78-53 | |
| » W: Kevin Tapani (13-7) L: Mike Mussina (2-4) S: Rick Aguilera (36) | First | -- |
| Sunday, September 1 |
| » Defeated Orioles (53-77), 14-3 | Hubert H. Humphrey Metrodome (41-24) | 79-53 | Won 2 |
| » W: Jack Morris (16-10) L: Arthur Rhodes (0-2) | First | -- |
| Monday, September 2 |
| » Defeated Indians (43-88), 9-3 | Hubert H. Humphrey Metrodome (42-24) | 80-53 | Won 3 |
| » W: Scott Erickson (17-6) L: Eric King (5-9) S: Rick Aguilera (37) | First | -- |
| Wednesday, September 4 |
| » Lost to Indians (44-88), 8-4 | Hubert H. Humphrey Metrodome (42-25) | 80-54 | |
| » W: Willie Blair (2-2) L: David West (4-4) S: Shawn Hillegas (7) | First | -- |
| » Major-league debuts: Jim Thome (Indians) |
| Friday, September 6 |
| » Defeated Yankees (60-73), 3-1 | Hubert H. Humphrey Metrodome (43-25) | 81-54 | |
| » W: Kevin Tapani (14-7) L: Wade Taylor (7-8) S: Rick Aguilera (38) | First | -- |
| Saturday, September 7 |
| » Defeated Yankees (60-74), 3-2 | Hubert H. Humphrey Metrodome (44-25) | 82-54 | Won 2 |
| » W: Carl Willis (8-3) L: Lee Guetterman (3-3) | First | -- |
| Sunday, September 8 |
| » Defeated Yankees (60-75), 6-5 | Hubert H. Humphrey Metrodome (45-25) | 83-54 | Won 3 |
| » W: Scott Erickson (18-6) L: Jeff Johnson (5-10) S: Steve Bedrosian (6) | First | -- |
| Monday, September 9 |
| » Defeated Royals (70-67), 10-4 | Royals Stadium (4-1) | 84-54 | Won 4 |
| » W: Tom Edens (1-1) L: Mike Boddicker (11-11) S: Gary Wayne (1) | First | -- |
| Tuesday, September 10 |
| » Defeated Royals (70-68), 7-2 | Royals Stadium (5-1) | 85-54 | Won 5 |
| » W: Allan Anderson (5-8) L: Mark Gubicza (8-9) S: Rick Aguilera (39) | First | -- |
| » Major-league debuts: Archie Corbin (Royals) |
| Wednesday, September 11 |
| » Lost to Royals (71-68), 4-1 | Royals Stadium (5-2) | 85-55 | |
| » W: Mark Davis (5-1) L: Kevin Tapani (14-8) S: Jeff Montgomery (28) | First | -- |
| Thursday, September 12 |
| » Lost to Rangers (74-65), 4-3 | Arlington Stadium (2-2) | 85-56 | Lost 2 |
| » W: Nolan Ryan (10-6) L: Jack Morris (16-11) S: Jeff Russell (27) | First | -- |
| Friday, September 13 |
| » Defeated Rangers (74-66), 7-3 | Arlington Stadium (3-2) | 86-56 | |
| » W: Terry Leach (1-1) L: Kenny Rogers (9-10) | First | -- |
| Saturday, September 14 |
| » Lost to Rangers (75-66), 3-0 | Arlington Stadium (3-3) | 86-57 | |
| » W: Oil Can Boyd (8-13) L: Tom Edens (1-2) S: Kenny Rogers (5) | First | -- |
| Sunday, September 15 |
| » Lost to Rangers (76-66), 4-2 | Arlington Stadium (3-4) | 86-58 | Lost 2 |
| » W: Jose Guzman (12-5) L: Allan Anderson (5-9) S: Jeff Russell (28) | First | -- |
| Monday, September 16 |
| » Defeated Royals (72-71), 9-0 | Hubert H. Humphrey Metrodome (46-25) | 87-58 | |
| » W: Kevin Tapani (15-8) L: Mark Gubicza (8-10) | First | -- |
| Tuesday, September 17 |
| » Lost to Royals (73-71), 4-1 | Hubert H. Humphrey Metrodome (46-26) | 87-59 | |
| » W: Bret Saberhagen (11-8) L: Jack Morris (16-12) S: Jeff Montgomery (29) | First | -- |
| Wednesday, September 18 |
| » Lost to Royals (74-71), 10-4 | Hubert H. Humphrey Metrodome (46-27) | 87-60 | Lost 2 |
| » W: Luis Aquino (8-3) L: Scott Erickson (18-7) | First | -- |
| Friday, September 20 |
| » Defeated Rangers (77-69), 6-4 | Hubert H. Humphrey Metrodome (47-27) | 88-60 | |
| » W: Gary Wayne (1-0) L: Wayne Rosenthal (1-3) S: Rick Aguilera (40) | |