| Sunday, January 27 |
| Former Pirate Dale Long dies in Palm Coast, FL at the age of 65. |
| Tuesday, February 26 |
| Former Pirate Jimmy Zinn dies in Memphis, TN at the age of 97. |
| Monday, April 1 |
| Former Pirate Frankie Gustine dies in Davenport, IA at the age of 72. |
| Monday, April 8 |
| » Lost to Expos (1-0), 7-0 | Three Rivers Stadium (0-1) | 0-1 | |
| » W: Dennis Martinez (1-0) L: Doug Drabek (0-1) | Third | 1 out |
| Tuesday, April 9 |
| » Defeated Expos (1-1), 4-3 | Three Rivers Stadium (1-1) | 1-1 | |
| » W: Bob Kipper (1-0) L: Steve Frey (0-1) S: Bill Landrum (1) | Third | 1 out |
| Wednesday, April 10 |
| » Defeated Expos (1-2), 6-3 | Three Rivers Stadium (2-1) | 2-1 | Won 2 |
| » W: Zane Smith (1-0) L: Oil Can Boyd (0-1) S: Stan Belinda (1) | First | -- |
| Thursday, April 11 |
| Former Pirate Walker Cooper dies in Scottsdale, AZ at the age of 77. |
| Friday, April 12 |
| » Defeated Cubs (1-3), 3-1 | Wrigley Field (1-0) | 3-1 | Won 3 |
| » W: John Smiley (1-0) L: Shawn Boskie (0-1) S: Vicente Palacios (1) | First | -- |
| Saturday, April 13 |
| » Lost to Cubs (2-3), 7-3 | Wrigley Field (1-1) | 3-2 | |
| » W: Mike Bielecki (1-0) L: Doug Drabek (0-2) | Second | ½ out |
| Sunday, April 14 |
| » Lost to Cubs (3-3), 6-4 | Wrigley Field (1-2) | 3-3 | Lost 2 |
| » W: Heathcliff Slocumb (1-0) L: Stan Belinda (0-1) S: Dave Smith (2) | Second | 1½ out |
| Monday, April 15 |
| » Lost to Mets (6-2), 9-3 | Three Rivers Stadium (2-2) | 3-4 | Lost 3 |
| » W: David Cone (1-0) L: Bob Kipper (1-1) | Third | 2½ out |
| Tuesday, April 16 |
| » Defeated Mets (6-3), 4-2 | Three Rivers Stadium (3-2) | 4-4 | |
| » W: Randy Tomlin (1-0) L: Wally Whitehurst (1-1) S: Stan Belinda (2) | Third | 1½ out |
| Wednesday, April 17 |
| » Defeated Mets (6-4), 4-0 | Three Rivers Stadium (4-2) | 5-4 | Won 2 |
| » W: John Smiley (2-0) L: Ron Darling (0-1) | Third | 1 out |
| Thursday, April 18 |
| » Lost to Cubs (7-3), 3-2 | Three Rivers Stadium (4-3) | 5-5 | |
| » W: Rick Sutcliffe (1-0) L: Doug Drabek (0-3) S: Paul Assenmacher (1) | Third | 2 out |
| Friday, April 19 |
| » Defeated Cubs (7-4), 5-4 | Three Rivers Stadium (5-3) | 6-5 | |
| » W: Stan Belinda (1-1) L: Dave Smith (0-1) | Second | 1 out |
| » Major-league debuts: Erik Pappas (Cubs) |
| Saturday, April 20 |
| » Defeated Cubs (7-5), 9-3 | Three Rivers Stadium (6-3) | 7-5 | Won 2 |
| » W: Zane Smith (2-0) L: Greg Maddux (2-1) | First | -- |
| Sunday, April 21 |
| » Defeated Cubs (7-6), 13-12 | Three Rivers Stadium (7-3) | 8-5 | Won 3 |
| » W: Bob Patterson (1-0) L: Mike Bielecki (2-1) | First | -- |
| Tuesday, April 23 |
| » Defeated Expos (5-9), 7-3 | Stade Olympique (1-0) | 9-5 | Won 4 |
| » W: John Smiley (3-0) L: Bill Sampen (1-1) | First | -- |
| Wednesday, April 24 |
| » Defeated Expos (5-10), 2-1 | Stade Olympique (2-0) | 10-5 | Won 5 |
| » W: Doug Drabek (1-3) L: Dennis Martinez (2-2) S: Bill Landrum (2) | First | -- |
| Thursday, April 25 |
| » Defeated Expos (5-11), 8-0 | Stade Olympique (3-0) | 11-5 | Won 6 |
| » W: Vicente Palacios (1-0) L: Chris Nabholz (0-3) | First | -- |
| Friday, April 26 |
| » Lost to Mets (11-6), 2-0 | Shea Stadium (0-1) | 11-6 | |
| » W: Frank Viola (3-0) L: Zane Smith (2-1) S: John Franco (5) | First | -- |
| Saturday, April 27 |
| » Defeated Mets (11-7), 10-1 | Shea Stadium (1-1) | 12-6 | |
| » W: Randy Tomlin (2-0) L: David Cone (2-1) | First | -- |
| Sunday, April 28 |
| » Defeated Mets (11-8), 7-3 | Shea Stadium (2-1) | 13-6 | Won 2 |
| » W: John Smiley (4-0) L: Ron Darling (1-2) | First | -- |
| Tuesday, April 30 |
| » Lost to Reds (11-8), 4-3 | Riverfront Stadium (0-1) | 13-7 | |
| » W: Tom Browning (3-1) L: Doug Drabek (1-4) S: Rob Dibble (5) | First | -- |
| Wednesday, May 1 |
| » Defeated Reds (11-9), 6-4 | Riverfront Stadium (1-1) | 14-7 | |
| » W: Stan Belinda (2-1) L: Randy Myers (0-2) S: Bill Landrum (3) | First | -- |
| Friday, May 3 |
| » Defeated Astros (8-13), 1-0 | Three Rivers Stadium (8-3) | 15-7 | Won 2 |
| » W: Zane Smith (3-1) L: Pete Harnisch (1-1) | First | -- |
| Saturday, May 4 |
| » Lost to Astros (9-13), 8-3 | Three Rivers Stadium (8-4) | 15-8 | |
| » W: Jimmy Jones (3-1) L: John Smiley (4-1) S: Jim Clancy (1) | First | -- |
| Former Pirate Bill Macdonald dies in Shasta Lake, CA at the age of 63. |
| Sunday, May 5 |
| » Lost to Astros (10-13), 6-4 | Three Rivers Stadium (8-5) | 15-9 | Lost 2 |
| » W: Mark Portugal (3-1) L: Doug Drabek (1-5) S: Curt Schilling (4) | First | -- |
| Monday, May 6 |
| » Defeated Reds (13-11), 3-1 | Three Rivers Stadium (9-5) | 16-9 | |
| » W: Vicente Palacios (2-0) L: Jose Rijo (1-2) S: Bill Landrum (4) | First | -- |
| Tuesday, May 7 |
| » Defeated Reds (13-12), 7-2 | Three Rivers Stadium (10-5) | 17-9 | Won 2 |
| » W: Randy Tomlin (3-0) L: Chris Hammond (3-1) S: Stan Belinda (3) | First | -- |
| Wednesday, May 8 |
| » Defeated Reds (13-13), 7-2 | Three Rivers Stadium (11-5) | 18-9 | Won 3 |
| » W: Zane Smith (4-1) L: Norm Charlton (1-3) | First | -- |
| Friday, May 10 |
| » Defeated Braves (13-12), 5-2 | Three Rivers Stadium (12-5) | 19-9 | Won 4 |
| » W: John Smiley (5-1) L: John Smoltz (1-4) S: Stan Belinda (4) | First | -- |
| Saturday, May 11 |
| » Lost to Braves (14-12), 3-2 | Three Rivers Stadium (12-6) | 19-10 | |
| » W: Charlie Leibrandt (3-3) L: Doug Drabek (1-6) S: Kent Mercker (3) | First | -- |
| Sunday, May 12 |
| » Lost to Braves (15-12), 6-1 | Three Rivers Stadium (12-7) | 19-11 | Lost 2 |
| » W: Steve Avery (4-1) L: Vicente Palacios (2-1) S: Juan Berenguer (3) | First | -- |
| Monday, May 13 |
| Former Pirate Hal Gregg dies in Bishop, CA at the age of 70. |
| Tuesday, May 14 |
| » Defeated Astros (12-18), 6-3 | Astrodome (1-0) | 20-11 | |
| » W: Zane Smith (5-1) L: Pete Harnisch (2-2) | First | -- |
| Wednesday, May 15 |
| » Defeated Astros (12-19), 8-7 | Astrodome (2-0) | 21-11 | Won 2 |
| » W: Bob Kipper (2-1) L: Curt Schilling (0-3) S: Bill Landrum (5) | First | -- |
| Thursday, May 16 |
| » Defeated Astros (12-20), 6-4 | Astrodome (3-0) | 22-11 | Won 3 |
| » W: Doug Drabek (2-6) L: Jim Clancy (0-1) S: Stan Belinda (5) | First | -- |
| Friday, May 17 |
| » Lost to Braves (17-14), 9-3 | Atlanta-Fulton County Stadium (0-1) | 22-12 | |
| » W: Steve Avery (5-1) L: Vicente Palacios (2-2) | First | -- |
| Sunday, May 19 |
| » Lost to Braves (18-14), 7-1 | Atlanta-Fulton County Stadium (0-2) | 22-13 | Lost 2 |
| » W: Tom Glavine (6-2) L: Zane Smith (5-2) S: Juan Berenguer (4) | First | -- |
| Tuesday, May 21 |
| » Defeated Cardinals (20-17), 5-3 | Three Rivers Stadium (13-7) | 23-13 | |
| » W: John Smiley (6-1) L: Jamie Moyer (0-5) S: Bill Landrum (6) | First | -- |
| Wednesday, May 22 |
| » Lost to Cardinals (21-17), 5-3 | Three Rivers Stadium (13-8) | 23-14 | |
| » W: Cris Carpenter (5-1) L: Doug Drabek (2-7) S: Lee Smith (12) | First | -- |
| Thursday, May 23 |
| » Lost to Cardinals (22-17), 8-2 | Three Rivers Stadium (13-9) | 23-15 | Lost 2 |
| » W: Jose DeLeon (2-3) L: Randy Tomlin (3-1) S: Scott Terry (1) | First | -- |
| Friday, May 24 |
| » Defeated Phillies (20-21), 9-1 | Three Rivers Stadium (14-9) | 24-15 | |
| » W: Zane Smith (6-2) L: Terry Mulholland (5-3) | First | -- |
| Saturday, May 25 |
| » Defeated Phillies (20-22), 4-2 | Three Rivers Stadium (15-9) | 25-15 | Won 2 |
| » W: Vicente Palacios (3-2) L: Joe Boever (3-4) | First | -- |
| Sunday, May 26 |
| » Defeated Phillies (20-23), 5-2 | Three Rivers Stadium (16-9) | 26-15 | Won 3 |
| » W: John Smiley (7-1) L: Jason Grimsley (1-6) S: Bill Landrum (7) | First | -- |
| Monday, May 27 |
| » Defeated Cardinals (24-19), 8-0 | Busch Stadium II (1-0) | 27-15 | Won 4 |
| » W: Doug Drabek (3-7) L: Bob Tewksbury (3-2) | First | -- |
| Tuesday, May 28 |
| » Defeated Cardinals (24-20), 9-8 | Busch Stadium II (2-0) | 28-15 | Won 5 |
| » W: Stan Belinda (3-1) L: Jose DeLeon (2-4) S: Bill Landrum (8) | First | -- |
| Wednesday, May 29 |
| » Defeated Cardinals (24-21), 6-0 | Busch Stadium II (3-0) | 29-15 | Won 6 |
| » W: Zane Smith (7-2) L: Bryn Smith (4-3) | First | -- |
| Friday, May 31 |
| » Defeated Phillies (22-25), 5-1 | Veteran's Stadium (1-0) | 30-15 | Won 7 |
| » W: Bob Walk (1-0) L: Jason Grimsley (1-7) | First | -- |
| Saturday, June 1 |
| » Defeated Phillies (22-26), 5-3 | Veteran's Stadium (2-0) | 31-15 | Won 8 |
| » W: John Smiley (8-1) L: Pat Combs (2-4) S: Bill Landrum (9) | First | -- |
| Sunday, June 2 |
| » Defeated Phillies (22-27), 5-3 | Veteran's Stadium (3-0) | 32-15 | Won 9 |
| » W: Bob Walk (2-0) L: Mitch Williams (0-3) S: Bob Patterson (1) | First | -- |
| Tuesday, June 4 |
| » Lost to Giants (19-32), 5-3 | Three Rivers Stadium (16-10) | 32-16 | |
| » W: John Burkett (3-3) L: Zane Smith (7-3) S: Dave Righetti (3) | First | -- |
| Wednesday, June 5 |
| » Defeated Giants (19-33), 7-3 | Three Rivers Stadium (17-10) | 33-16 | |
| » W: Bob Walk (3-0) L: Kelly Downs (2-4) | First | -- |
| Thursday, June 6 |
| » Lost to Giants (20-33), 6-3 | Three Rivers Stadium (17-11) | 33-17 | |
| » W: Bud Black (6-5) L: John Smiley (8-2) S: Dave Righetti (4) | First | -- |
| Friday, June 7 |
| » Defeated Padres (28-27), 1-0 | Three Rivers Stadium (18-11) | 34-17 | |
| » W: Doug Drabek (4-7) L: Bruce Hurst (6-3) S: Bill Landrum (10) | First | -- |
| Saturday, June 8 |
| » Lost to Padres (29-27), 11-0 | Three Rivers Stadium (18-12) | 34-18 | |
| » W: Mike Maddux (3-1) L: Randy Tomlin (3-2) | First | -- |
| Sunday, June 9 |
| » Lost to Padres (30-27), 5-3 | Three Rivers Stadium (18-13) | 34-19 | Lost 2 |
| » W: Andy Benes (4-6) L: Zane Smith (7-4) S: Craig Lefferts (13) | First | -- |
| Monday, June 10 |
| » Defeated Padres (30-28), 5-3 | Three Rivers Stadium (19-13) | 35-19 | |
| » W: Vicente Palacios (4-2) L: Dennis Rasmussen (2-1) S: Bill Landrum (11) | First | -- |
| Wednesday, June 12 |
| » Defeated Dodgers (33-24), 2-1 | Three Rivers Stadium (20-13) | 36-19 | Won 2 |
| » W: Doug Drabek (5-7) L: Mike Morgan (6-5) S: Bill Landrum (12) | First | -- |
| Thursday, June 13 |
| » Lost to Dodgers (34-24), 3-2 | Three Rivers Stadium (20-14) | 36-20 | |
| » W: Jim Gott (1-1) L: Randy Tomlin (3-3) S: Jay Howell (11) | First | -- |
| Friday, June 14 |
| » Lost to Giants (24-37), 3-2 | Candlestick Park (0-1) | 36-21 | Lost 2 |
| » W: Francisco Oliveras (2-2) L: Zane Smith (7-5) S: Dave Righetti (7) | First | -- |
| Saturday, June 15 |
| » Lost to Giants (25-37), 4-0 | Candlestick Park (0-2) | 36-22 | Lost 3 |
| » W: Mike Remlinger (1-0) L: John Smiley (8-3) | First | -- |
| » Major-league debuts: Mike Remlinger (Giants) |
| Sunday, June 16 |
| » Defeated Giants (25-38), 4-3 | Candlestick Park (1-2) | 37-22 | |
| » W: Bob Walk (4-0) L: Bud Black (6-6) S: Bill Landrum (13) | First | -- |
| Monday, June 17 |
| » Defeated Padres (33-32), 3-2 | San Diego/Jack Murphy Stadium (1-0) | 38-22 | Won 2 |
| » W: Doug Drabek (6-7) L: Bruce Hurst (7-4) S: Vicente Palacios (2) | First | -- |
| Tuesday, June 18 |
| » Defeated Padres (33-33), 3-1 | San Diego/Jack Murphy Stadium (2-0) | 39-22 | Won 3 |
| » W: Bill Landrum (1-0) L: Craig Lefferts (0-3) | First | -- |
| Wednesday, June 19 |
| » Lost to Padres (34-33), 6-5 | San Diego/Jack Murphy Stadium (2-1) | 39-23 | |
| » W: Larry Andersen (2-0) L: Neal Heaton (0-1) | First | -- |
| Thursday, June 20 |
| » Lost to Dodgers (40-25), 3-2 | Dodger Stadium (0-1) | 39-24 | Lost 2 |
| » W: Kevin Gross (4-5) L: John Smiley (8-4) | First | -- |
| Friday, June 21 |
| » Defeated Dodgers (40-26), 5-1 | Dodger Stadium (1-1) | 40-24 | |
| » W: Bob Walk (5-0) L: Bob Ojeda (6-5) S: Bob Kipper (1) | First | -- |
| Saturday, June 22 |
| » Lost to Dodgers (41-26), 4-1 | Dodger Stadium (1-2) | 40-25 | |
| » W: Mike Morgan (8-5) L: Doug Drabek (6-8) | First | -- |
| Sunday, June 23 |
| » Lost to Dodgers (42-26), 2-0 | Dodger Stadium (1-3) | 40-26 | Lost 2 |
| » W: Tim Belcher (7-4) L: Zane Smith (7-6) S: Tim Crews (5) | First | -- |
| Tuesday, June 25 |
| » Lost to Cubs (32-38), 5-1 | Three Rivers Stadium (20-15) | 40-27 | Lost 3 |
| » W: Les Lancaster (3-2) L: John Smiley (8-5) | First | -- |
| Wednesday, June 26 |
| » Defeated Cubs (32-39), 7-6 | Three Rivers Stadium (21-15) | 41-27 | |
| » W: Bob Walk (6-0) L: Greg Maddux (6-6) S: Bill Landrum (14) | First | -- |
| Thursday, June 27 |
| » Defeated Cubs (32-40), 4-3 | Three Rivers Stadium (22-15) | 42-27 | Won 2 |
| » W: Vicente Palacios (5-2) L: Paul Assenmacher (3-4) | First | -- |
| Friday, June 28 |
| » Defeated Expos (33-40), 6-1 | Stade Olympique (4-0) | 43-27 | Won 3 |
| » W: Zane Smith (8-6) L: Chris Haney (0-2) | First | -- |
| Saturday, June 29 |
| » Defeated Expos (33-41), 2-1 | Stade Olympique (5-0) | 44-27 | Won 4 |
| » W: Neal Heaton (1-1) L: Scott Ruskin (2-2) S: Bill Landrum (15) | First | -- |
| Sunday, June 30 |
| » Defeated Expos (33-42), 2-1 | Stade Olympique (6-0) | 45-27 | Won 5 |
| » W: John Smiley (9-5) L: Dennis Martinez (9-5) S: Stan Belinda (6) | First | -- |
| Monday, July 1 |
| » Lost to Cubs (35-41), 6-5 | Wrigley Field (1-3) | 45-28 | |
| » W: Bob Scanlan (3-3) L: Stan Belinda (3-2) | First | -- |
| Tuesday, July 2 |
| » Defeated Cubs (35-42), 13-4 | Wrigley Field (2-3) | 46-28 | |
| » W: Doug Drabek (7-8) L: Shawn Boskie (3-8) | First | -- |
| Wednesday, July 3 |
| » Defeated Cubs (35-43), 11-7 | Wrigley Field (3-3) | 47-28 | Won 2 |
| » W: Zane Smith (9-6) L: Les Lancaster (4-3) | First | -- |
| » Major-league debuts: Laddie Renfroe (Cubs) |
| Thursday, July 4 |
| » Lost to Cubs (36-43), 9-8 | Wrigley Field (3-4) | 47-29 | |
| » W: Chuck McElroy (5-0) L: Bill Landrum (1-1) | First | -- |
| Friday, July 5 |
| » Lost to Expos (34-46), 4-3 | Three Rivers Stadium (22-16) | 47-30 | Lost 2 |
| » W: Dennis Martinez (10-5) L: John Smiley (9-6) | First | -- |
| Saturday, July 6 |
| » Lost to Expos (35-46), 2-1 | Three Rivers Stadium (22-17) | 47-31 | Lost 3 |
| » W: Mark Gardner (4-5) L: Bob Walk (6-1) S: Tim Burke (5) | First | -- |
| Sunday, July 7 |
| » Defeated Expos (35-47), 6-1 | Three Rivers Stadium (23-17) | 48-31 | |
| » W: Doug Drabek (8-8) L: Oil Can Boyd (4-8) S: Stan Belinda (7) | First | -- |
| Thursday, July 11 |
| » Defeated Reds (44-37), 10-6 | Riverfront Stadium (2-1) | 49-31 | Won 2 |
| » W: Vicente Palacios (6-2) L: Randy Myers (4-6) | First | -- |
| Friday, July 12 |
| » Defeated Reds (44-38), 7-2 | Riverfront Stadium (3-1) | 50-31 | Won 3 |
| » W: Doug Drabek (9-8) L: Jack Armstrong (6-8) | First | -- |
| Saturday, July 13 |
| » Defeated Reds (44-39), 5-2 | Riverfront Stadium (4-1) | 51-31 | Won 4 |
| » W: John Smiley (10-6) L: Tom Browning (10-6) S: Bob Kipper (2) | First | -- |
| Sunday, July 14 |
| » Defeated Reds (44-40), 10-6 | Riverfront Stadium (5-1) | 52-31 | Won 5 |
| » W: Bob Walk (7-1) L: Kip Gross (2-1) S: Bob Patterson (2) | First | -- |
| Monday, July 15 |
| » Defeated Astros (35-51), 8-0 | Three Rivers Stadium (24-17) | 53-31 | Won 6 |
| » W: Randy Tomlin (4-3) L: Jimmy Jones (5-6) | First | -- |
| Tuesday, July 16 |
| » Defeated Astros (35-52), 6-4 | Three Rivers Stadium (25-17) | 54-31 | Won 7 |
| » W: Zane Smith (10-6) L: Darryl Kile (3-4) S: Stan Belinda (8) | First | -- |
| Wednesday, July 17 |
| » Lost to Astros (36-52), 10-2 | Three Rivers Stadium (25-18) | 54-32 | |
| » W: Jimmy Jones (6-6) L: Doug Drabek (9-9) S: Al Osuna (6) | First | -- |
| » Major-league debuts: John Wehner (Pirates) |
| Friday, July 19 |
| » Defeated Reds (44-44), 7-2 | Three Rivers Stadium (26-18) | 55-32 | |
| » W: John Smiley (11-6) L: Tom Browning (10-7) | First | -- |
| Saturday, July 20 |
| » Lost to Reds (45-44), 3-2 | Three Rivers Stadium (26-19) | 55-33 | |
| » W: Kip Gross (3-1) L: Bob Walk (7-2) S: Ted Power (1) | First | -- |
| Sunday, July 21 |
| » Defeated Reds (45-45), 6-0 | Three Rivers Stadium (27-19) | 56-33 | |
| » W: Randy Tomlin (5-3) L: Chris Hammond (7-6) | First | -- |
| Monday, July 22 |
| » Lost to Braves (48-42), 7-3 | Three Rivers Stadium (27-20) | 56-34 | |
| » W: John Smoltz (5-11) L: Zane Smith (10-7) | First | -- |
| Tuesday, July 23 |
| » Defeated Braves (48-43), 12-3 | Three Rivers Stadium (28-20) | 57-34 | |
| » W: Doug Drabek (10-9) L: Charlie Leibrandt (9-8) | First | -- |
| » Major-league debuts: Keith Mitchell (Braves) |
| Wednesday, July 24 |
| » Defeated Braves (48-44), 7-4 | Three Rivers Stadium (29-20) | 58-34 | Won 2 |
| » W: John Smiley (12-6) L: Tom Glavine (13-5) S: Stan Belinda (9) | First | -- |
| Friday, July 26 |
| » Defeated Astros (37-58), 8-1 | Astrodome (4-0) | 59-34 | Won 3 |
| » W: Neal Heaton (2-1) L: Darryl Kile (3-6) | First | -- |
| Saturday, July 27 |
| » Defeated Astros (37-59), 11-5 | Astrodome (5-0) | 60-34 | Won 4 |
| » W: Randy Tomlin (6-3) L: Jimmy Jones (6-7) | First | -- |
| Sunday, July 28 |
| » Lost to Astros (38-59), 9-7 | Astrodome (5-1) | 60-35 | |
| » W: Ryan Bowen (1-1) L: Zane Smith (10-8) S: Jim Clancy (5) | First | -- |
| » Major-league debuts: Jose Tolentino (Astros) |
| Monday, July 29 |
| » Lost to Braves (50-46), 7-5 | Atlanta-Fulton County Stadium (0-3) | 60-36 | Lost 2 |
| » W: Tom Glavine (14-5) L: Doug Drabek (10-10) S: Marvin Freeman (1) | First | -- |
| » Lost to Braves (51-46), 5-3 | Atlanta-Fulton County Stadium (0-4) | 60-37 | Lost 3 |
| » W: Rick Mahler (2-4) L: John Smiley (12-7) S: Kent Mercker (5) | First | -- |
| Tuesday, July 30 |
| » Lost to Braves (52-46), 10-3 | Atlanta-Fulton County Stadium (0-5) | 60-38 | Lost 4 |
| » W: Jeff Parrett (1-2) L: Bill Landrum (1-2) S: Kent Mercker (6) | First | -- |
| » Major-league debuts: Paul Miller (Pirates) |
| Wednesday, July 31 |
| » Lost to Braves (53-46), 8-6 | Atlanta-Fulton County Stadium (0-6) | 60-39 | Lost 5 |
| » W: John Smoltz (6-12) L: Vicente Palacios (6-3) S: Mike Stanton (2) | First | -- |
| Thursday, August 1 |
| » Lost to Cardinals (54-47), 6-3 | Busch Stadium II (3-1) | 60-40 | Lost 6 |
| » W: Omar Olivares (4-3) L: Randy Tomlin (6-4) S: Lee Smith (28) | First | -- |
| Friday, August 2 |
| » Lost to Cardinals (55-47), 4-3 | Busch Stadium II (3-2) | 60-41 | Lost 7 |
| » W: Bob McClure (1-0) L: Stan Belinda (3-3) | First | -- |
| Saturday, August 3 |
| » Lost to Cardinals (56-47), 6-5 | Busch Stadium II (3-3) | 60-42 | Lost 8 |
| » W: Lee Smith (6-2) L: Bob Patterson (1-1) | First | -- |
| Sunday, August 4 |
| » Defeated Cardinals (56-48), 2-1 | Busch Stadium II (4-3) | 61-42 | |
| » W: John Smiley (13-7) L: Ken Hill (8-8) | First | -- |
| Monday, August 5 |
| » Major-league debuts: Anthony Young (Mets) |
| Tuesday, August 6 |
| » Defeated Mets (55-50), 3-1 | Shea Stadium (3-1) | 62-42 | Won 2 |
| » W: Randy Tomlin (7-4) L: Sid Fernandez (0-2) | First | -- |
| Wednesday, August 7 |
| » Lost to Mets (56-50), 7-1 | Shea Stadium (3-2) | 62-43 | |
| » W: Dwight Gooden (12-6) L: Zane Smith (10-9) | First | -- |
| Thursday, August 8 |
| » Lost to Mets (57-50), 4-3 | Shea Stadium (3-3) | 62-44 | Lost 2 |
| » W: Frank Viola (12-8) L: Doug Drabek (10-11) S: John Franco (22) | First | -- |
| Friday, August 9 |
| » Lost to Cardinals (58-49), 5-1 | Three Rivers Stadium (29-21) | 62-45 | Lost 3 |
| » W: Bryn Smith (10-7) L: John Smiley (13-8) | First | -- |
| Saturday, August 10 |
| » Defeated Cardinals (58-50), 11-5 | Three Rivers Stadium (30-21) | 63-45 | |
| » W: Neal Heaton (3-1) L: Ken Hill (8-9) | First | -- |
| » Major-league debuts: Hector Fajardo (Pirates) |
| Sunday, August 11 |
| » Defeated Cardinals (58-51), 6-4 | Three Rivers Stadium (31-21) | 64-45 | Won 2 |
| » W: Roger Mason (1-0) L: Bob Tewksbury (7-8) S: Bill Landrum (16) | First | -- |
| Monday, August 12 |
| » Defeated Cardinals (58-52), 4-3 | Three Rivers Stadium (32-21) | 65-45 | Won 3 |
| » W: Bob Patterson (2-1) L: Lee Smith (6-3) | First | -- |
| Tuesday, August 13 |
| » Defeated Phillies (53-59), 4-3 | Three Rivers Stadium (33-21) | 66-45 | Won 4 |
| » W: Doug Drabek (11-11) L: Danny Cox (4-5) S: Stan Belinda (10) | First | -- |
| Wednesday, August 14 |
| » Defeated Phillies (53-60), 5-3 | Three Rivers Stadium (34-21) | 67-45 | Won 5 |
| » W: John Smiley (14-8) L: Tommy Greene (8-5) S: Stan Belinda (11) | First | -- |
| Thursday, August 15 |
| » Lost to Phillies (54-60), 6-4 | Three Rivers Stadium (34-22) | 67-46 | |
| » W: Jose DeJesus (9-4) L: Neal Heaton (3-2) S: Mitch Williams (22) | First | -- |
| Friday, August 16 |
| » Defeated Mets (57-58), 8-2 | Three Rivers Stadium (35-22) | 68-46 | |
| » W: Randy Tomlin (8-4) L: Sid Fernandez (0-3) | First | -- |
| Saturday, August 17 |
| » Defeated Mets (57-59), 4-1 | Three Rivers Stadium (36-22) | 69-46 | Won 2 |
| » W: Zane Smith (11-9) L: Dwight Gooden (12-7) S: Stan Belinda (12) | First | -- |
| Sunday, August 18 |
| » Defeated Mets (57-60), 9-2 | Three Rivers Stadium (37-22) | 70-46 | Won 3 |
| » W: Doug Drabek (12-11) L: Frank Viola (12-10) | First | -- |
| Tuesday, August 20 |
| » Lost to Phillies (56-62), 6-5 | Veteran's Stadium (3-1) | 70-47 | |
| » W: Steve Searcy (3-3) L: Stan Belinda (3-4) | First | -- |
| Wednesday, August 21 |
| » Lost to Phillies (57-62), 6-5 | Veteran's Stadium (3-2) | 70-48 | Lost 2 |
| » W: Mitch Williams (7-4) L: Bob Kipper (2-2) | First | -- |
| Thursday, August 22 |
| » Lost to Phillies (58-62), 4-3 | Veteran's Stadium (3-3) | 70-49 | Lost 3 |
| » W: Mitch Williams (8-4) L: Bill Landrum (1-3) | First | -- |
| Friday, August 23 |
| » Defeated Giants (59-62), 8-0 | Three Rivers Stadium (38-22) | 71-49 | |
| » W: Doug Drabek (13-11) L: John Burkett (9-8) | First | -- |
| Saturday, August 24 |
| » Lost to Giants (60-62), 5-1 | Three Rivers Stadium (38-23) | 71-50 | |
| » W: Trevor Wilson (9-9) L: Neal Heaton (3-3) | First | -- |
| Sunday, August 25 |
| » Defeated Giants (60-63), 8-3 | Three Rivers Stadium (39-23) | 72-50 | |
| » W: John Smiley (15-8) L: Francisco Oliveras (4-3) S: Stan Belinda (13) | First | -- |
| Monday, August 26 |
| » Lost to Padres (61-64), 7-5 | Three Rivers Stadium (39-24) | 72-51 | |
| » W: Craig Lefferts (1-5) L: Bill Landrum (1-4) | First | -- |
| Tuesday, August 27 |
| » Defeated Padres (61-65), 5-2 | Three Rivers Stadium (40-24) | 73-51 | |
| » W: Zane Smith (12-9) L: Ricky Bones (1-3) S: Roger Mason (1) | First | -- |
| Wednesday, August 28 |
| » Defeated Dodgers (69-57), 6-4 | Dodger Stadium (2-3) | 74-51 | Won 2 |
| » W: Rosario Rodriguez (1-0) L: Roger McDowell (4-8) S: Stan Belinda (14) | First | -- |
| Thursday, August 29 |
| » Defeated Dodgers (69-58), 4-1 | Dodger Stadium (3-3) | 75-51 | Won 3 |
| » W: Roger Mason (2-0) L: Mike Morgan (10-9) S: Bill Landrum (17) | First | -- |
| Friday, August 30 |
| » Defeated Padres (63-66), 4-1 | San Diego/Jack Murphy Stadium (3-1) | 76-51 | Won 4 |
| » W: John Smiley (16-8) L: Dennis Rasmussen (4-11) S: Rosario Rodriguez (1) | First | -- |
| Saturday, August 31 |
| » Defeated Padres (63-67), 3-2 | San Diego/Jack Murphy Stadium (4-1) | 77-51 | Won 5 |
| » W: Bill Landrum (2-4) L: Jose Melendez (6-4) S: Bob Kipper (3) | First | -- |
| Sunday, September 1 |
| » Lost to Padres (64-67), 7-4 | San Diego/Jack Murphy Stadium (4-2) | 77-52 | |
| » W: Ricky Bones (2-3) L: Zane Smith (12-10) S: Mike Maddux (3) | First | -- |
| Monday, September 2 |
| » Defeated Giants (62-69), 9-8 | Candlestick Park (2-2) | 78-52 | |
| » W: Stan Belinda (4-4) L: Dave Righetti (2-6) S: Rosario Rodriguez (2) | First | -- |
| Tuesday, September 3 |
| » Defeated Giants (62-70), 5-3 | Candlestick Park (3-2) | 79-52 | Won 2 |
| » W: Bob Patterson (3-1) L: Francisco Oliveras (4-5) | First | -- |
| » Major-league debuts: Scott Bullett (Pirates) |
| Wednesday, September 4 |
| » Defeated Giants (62-71), 8-3 | Candlestick Park (4-2) | 80-52 | Won 3 |
| » W: John Smiley (17-8) L: Bud Black (10-14) S: Roger Mason (2) | First | -- |
| » Major-league debuts: Ted Wood (Giants) |
| Friday, September 6 |
| » Lost to Dodgers (75-59), 4-3 | Three Rivers Stadium (40-25) | 80-53 | |
| » W: Roger McDowell (7-8) L: Stan Belinda (4-5) | First | -- |
| » Defeated Dodgers (75-60), 3-1 | Three Rivers Stadium (41-25) | 81-53 | |
| » W: Zane Smith (13-10) L: Kevin Gross (8-10) | First | -- |
| Saturday, September 7 |
| » Lost to Dodgers (76-60), 5-1 | Three Rivers Stadium (41-26) | 81-54 | |
| » W: Bob Ojeda (10-8) L: Doug Drabek (13-12) S: Jim Gott (2) | First | -- |
| Sunday, September 8 |
| » Lost to Dodgers (77-60), 5-1 | Three Rivers Stadium (41-27) | 81-55 | Lost 2 |
| » W: Mike Morgan (11-9) L: Bob Patterson (3-2) | First | -- |
| Monday, September 9 |
| » Defeated Cubs (68-69), 12-10 | Wrigley Field (4-4) | 82-55 | |
| » W: Stan Belinda (5-5) L: Dave Smith (0-6) S: Rosario Rodriguez (3) | First | -- |
| Tuesday, September 10 |
| » Lost to Cubs (69-69), 6-2 | Wrigley Field (4-5) | 82-56 | |
| » W: Rick Sutcliffe (5-4) L: Randy Tomlin (8-5) S: Bob Scanlan (1) | First | -- |
| Wednesday, September 11 |
| » Defeated Cardinals (72-66), 3-1 | Busch Stadium II (5-3) | 83-56 | |
| » W: Zane Smith (14-10) L: Bob Tewksbury (9-11) | First | -- |
| » Major-league debuts: Stan Royer (Cardinals) |
| Thursday, September 12 |
| » Lost to Cardinals (73-66), 1-0 | Busch Stadium II (5-4) | 83-57 | |
| » W: Ken Hill (9-9) L: Doug Drabek (13-13) S: Lee Smith (39) | First | -- |
| Friday, September 13 |
| » Defeated Phillies (66-75), 8-6 | Veteran's Stadium (4-3) | 84-57 | |
| » W: Stan Belinda (6-5) L: Mitch Williams (10-5) S: Rosario Rodriguez (4) | First | -- |
| Saturday, September 14 |
| » Defeated Phillies (66-76), 5-3 | Veteran's Stadium (5-3) | 85-57 | Won 2 |
| » W: John Smiley (18-8) L: Andy Ashby (0-4) S: Vicente Palacios (3) | First | -- |
| Sunday, September 15 |
| » Lost to Phillies (67-76), 8-3 | Veteran's Stadium (5-4) | 85-58 | |
| » W: Tommy Greene (11-7) L: Randy Tomlin (8-6) S: Mitch Williams (27) | First | -- |
| Former Pirate Smoky Burgess dies in Asheville, NC at the age of 65. |
| Monday, September 16 |
| » Defeated Cubs (70-74), 5-4 | Three Rivers Stadium (42-27) | 86-58 | |
| » W: Zane Smith (15-10) L: Frank Castillo (6-5) S: Roger Mason (3) | First | -- |
| Tuesday, September 17 |
| » Defeated Cubs (70-75), 9-2 | Three Rivers Stadium (43-27) | |
