| Sunday, January 6 |
| Former Padre Alan Wiggins dies in Los Angeles, CA at the age of 33. |
| Monday, April 8 |
| » Major-league debuts: Mike Timlin (Blue Jays) |
| Tuesday, April 9 |
| » Defeated Giants (0-1), 7-4 | San Diego/Jack Murphy Stadium (1-0) | 1-0 | |
| » W: Mike Maddux (1-0) L: Trevor Wilson (0-1) S: Larry Andersen (1) | First | -- |
| Wednesday, April 10 |
| » Defeated Giants (0-2), 4-3 | San Diego/Jack Murphy Stadium (2-0) | 2-0 | Won 2 |
| » W: Bruce Hurst (1-0) L: Bud Black (0-1) S: Craig Lefferts (1) | First | -- |
| Thursday, April 11 |
| » Lost to Giants (1-2), 11-9 | San Diego/Jack Murphy Stadium (2-1) | 2-1 | |
| » W: Dave Righetti (1-0) L: Craig Lefferts (0-1) | Second | ½ out |
| Friday, April 12 |
| » Defeated Dodgers (2-1), 4-2 | Dodger Stadium (1-0) | 3-1 | |
| » W: Greg Harris (1-0) L: Bob Ojeda (0-1) S: Wes Gardner (1) | First | -- |
| Saturday, April 13 |
| » Defeated Dodgers (2-2), 6-3 | Dodger Stadium (2-0) | 4-1 | Won 2 |
| » W: Eric Nolte (1-0) L: Kevin Gross (0-1) S: Mike Maddux (1) | First | -- |
| Sunday, April 14 |
| » Defeated Dodgers (2-3), 5-3 | Dodger Stadium (3-0) | 5-1 | Won 3 |
| » W: Ed Whitson (1-0) L: Mike Morgan (0-1) S: Craig Lefferts (2) | First | -- |
| Monday, April 15 |
| » Defeated Reds (2-4), 3-2 | San Diego/Jack Murphy Stadium (3-1) | 6-1 | Won 4 |
| » W: Mike Maddux (2-0) L: Ted Power (1-1) | First | -- |
| Tuesday, April 16 |
| » Lost to Reds (3-4), 1-0 | San Diego/Jack Murphy Stadium (3-2) | 6-2 | |
| » W: Norm Charlton (1-1) L: Andy Benes (0-1) S: Randy Myers (2) | First | -- |
| Wednesday, April 17 |
| » Lost to Reds (4-4), 5-1 | San Diego/Jack Murphy Stadium (3-3) | 6-3 | Lost 2 |
| » W: Chris Hammond (1-0) L: Greg Harris (1-1) S: Scott Scudder (1) | First | -- |
| Thursday, April 18 |
| » Defeated Dodgers (4-5), 10-5 | San Diego/Jack Murphy Stadium (4-3) | 7-3 | |
| » W: Eric Nolte (2-0) L: Kevin Gross (0-2) | First | -- |
| Friday, April 19 |
| » Lost to Dodgers (5-5), 4-0 | San Diego/Jack Murphy Stadium (4-4) | 7-4 | |
| » W: Mike Morgan (1-1) L: Ed Whitson (1-1) | First | -- |
| Saturday, April 20 |
| » Defeated Dodgers (5-6), 5-3 | San Diego/Jack Murphy Stadium (5-4) | 8-4 | |
| » W: Larry Andersen (1-0) L: Tim Belcher (2-1) S: Craig Lefferts (3) | First | -- |
| Sunday, April 21 |
| » Lost to Dodgers (6-6), 6-0 | San Diego/Jack Murphy Stadium (5-5) | 8-5 | |
| » W: Ramon Martinez (2-1) L: Andy Benes (0-2) | First | -- |
| Monday, April 22 |
| » Defeated Giants (6-7), 7-5 | Candlestick Park (1-0) | 9-5 | |
| » W: Pat Clements (1-0) L: Trevor Wilson (0-2) S: Craig Lefferts (4) | First | -- |
| Tuesday, April 23 |
| » Defeated Giants (6-8), 7-6 | Candlestick Park (2-0) | 10-5 | Won 2 |
| » W: Eric Nolte (3-0) L: Scott Garrelts (1-1) S: Craig Lefferts (5) | First | -- |
| Wednesday, April 24 |
| » Lost to Giants (7-8), 6-1 | Candlestick Park (2-1) | 10-6 | |
| » W: John Burkett (2-1) L: Ed Whitson (1-2) | First | -- |
| Friday, April 26 |
| » Defeated Phillies (5-12), 4-0 | Veteran's Stadium (1-0) | 11-6 | |
| » W: Bruce Hurst (2-0) L: Jose DeJesus (0-1) | First | -- |
| Saturday, April 27 |
| » Lost to Phillies (6-12), 4-3 | Veteran's Stadium (1-1) | 11-7 | |
| » W: Darrel Akerfelds (1-1) L: Mike Maddux (2-1) | First | -- |
| Sunday, April 28 |
| » Lost to Phillies (7-12), 9-2 | Veteran's Stadium (1-2) | 11-8 | Lost 2 |
| » W: Jason Grimsley (1-3) L: Eric Nolte (3-1) | First | -- |
| Monday, April 29 |
| » Lost to Phillies (8-12), 7-2 | Veteran's Stadium (1-3) | 11-9 | Lost 3 |
| » W: Terry Mulholland (2-2) L: Ed Whitson (1-3) | Second | 1 out |
| Tuesday, April 30 |
| » Lost to Mets (12-8), 6-3 | Shea Stadium (0-1) | 11-10 | Lost 4 |
| » W: Dwight Gooden (3-1) L: Derek Lilliquist (0-1) S: Alejandro Pena (1) | Second | 1 out |
| Wednesday, May 1 |
| » Defeated Mets (12-9), 8-7 | Shea Stadium (1-1) | 12-10 | |
| » W: Bruce Hurst (3-0) L: Frank Viola (3-1) S: Craig Lefferts (6) | Second | 1 out |
| Friday, May 3 |
| » Lost to Expos (9-13), 4-1 | Stade Olympique (0-1) | 12-11 | |
| » W: Oil Can Boyd (1-3) L: Andy Benes (0-3) | Second | 1 out |
| Saturday, May 4 |
| » Defeated Expos (9-14), 6-5 | Stade Olympique (1-1) | 13-11 | |
| » W: Rich Rodriguez (1-0) L: Jeff Fassero (0-1) | Second | 1 out |
| » Major-league debuts: Jeff Fassero (Expos) |
| Sunday, May 5 |
| » Defeated Expos (9-15), 6-3 | Stade Olympique (2-1) | 14-11 | Won 2 |
| » W: Ed Whitson (2-3) L: Brian Barnes (0-1) | Second | 1 out |
| Tuesday, May 7 |
| » Defeated Phillies (11-15), 4-2 | San Diego/Jack Murphy Stadium (6-5) | 15-11 | Won 3 |
| » W: Bruce Hurst (4-0) L: Jose DeJesus (0-2) S: Craig Lefferts (7) | First | -- |
| Wednesday, May 8 |
| » Lost to Phillies (12-15), 5-2 | San Diego/Jack Murphy Stadium (6-6) | 15-12 | |
| » W: Danny Cox (1-1) L: Andy Benes (0-4) S: Roger McDowell (2) | First | -- |
| Thursday, May 9 |
| » Lost to Phillies (13-15), 9-6 | San Diego/Jack Murphy Stadium (6-7) | 15-13 | Lost 2 |
| » W: Terry Mulholland (4-2) L: Derek Lilliquist (0-2) S: Mitch Williams (7) | Second | 2 out |
| Friday, May 10 |
| » Lost to Expos (13-15), 6-4 | San Diego/Jack Murphy Stadium (6-8) | 15-14 | Lost 3 |
| » W: Tim Burke (3-1) L: Wes Gardner (0-1) | Third | 2 out |
| » Major-league debuts: Kevin Ward (Padres) |
| Saturday, May 11 |
| » Lost to Expos (14-15), 5-1 | San Diego/Jack Murphy Stadium (6-9) | 15-15 | Lost 4 |
| » W: Dennis Martinez (5-2) L: Adam Peterson (0-1) | Fourth | 2 out |
| Sunday, May 12 |
| » Lost to Expos (15-15), 8-6 | San Diego/Jack Murphy Stadium (6-10) | 15-16 | Lost 5 |
| » W: Bill Sampen (2-1) L: Rich Rodriguez (1-1) S: Barry Jones (2) | Third | 2 out |
| Monday, May 13 |
| » Defeated Mets (17-13), 5-2 | San Diego/Jack Murphy Stadium (7-10) | 16-16 | |
| » W: Andy Benes (1-4) L: David Cone (3-2) S: Craig Lefferts (8) | Fourth | 2 out |
| Tuesday, May 14 |
| » Lost to Mets (18-13), 6-1 | San Diego/Jack Murphy Stadium (7-11) | 16-17 | |
| » W: Wally Whitehurst (2-1) L: Eric Nolte (3-2) S: Pete Schourek (2) | Fourth | 2 out |
| Wednesday, May 15 |
| » Lost to Mets (19-13), 7-1 | San Diego/Jack Murphy Stadium (7-12) | 16-18 | Lost 2 |
| » W: Dwight Gooden (4-3) L: Ed Whitson (2-4) | Fourth | 3 out |
| Friday, May 17 |
| » Lost to Reds (17-16), 7-3 | Riverfront Stadium (0-1) | 16-19 | Lost 3 |
| » W: Randy Myers (1-3) L: Bruce Hurst (4-1) S: Rob Dibble (10) | Fourth | 3 out |
| Saturday, May 18 |
| » Defeated Reds (17-17), 5-2 | Riverfront Stadium (1-1) | 17-19 | |
| » W: Adam Peterson (1-1) L: Jack Armstrong (3-2) | Fourth | 3 out |
| » Major-league debuts: Reggie Jefferson (Reds) |
| Sunday, May 19 |
| » Defeated Reds (17-18), 3-2 | Riverfront Stadium (2-1) | 18-19 | Won 2 |
| » W: Andy Benes (2-4) L: Norm Charlton (2-4) S: Craig Lefferts (9) | Fourth | 3 out |
| Monday, May 20 |
| » Defeated Braves (18-15), 7-3 | Atlanta-Fulton County Stadium (1-0) | 19-19 | Won 3 |
| » W: Ed Whitson (3-4) L: John Smoltz (1-5) | Third | 2 out |
| Tuesday, May 21 |
| » Lost to Braves (19-15), 4-1 | Atlanta-Fulton County Stadium (1-1) | 19-20 | |
| » W: Kent Mercker (2-2) L: Steve Rosenberg (0-1) | Fourth | 3 out |
| Wednesday, May 22 |
| » Defeated Braves (19-16), 7-2 | Atlanta-Fulton County Stadium (2-1) | 20-20 | |
| » W: Bruce Hurst (5-1) L: Steve Avery (5-2) | Fourth | 2 out |
| Thursday, May 23 |
| » Defeated Braves (19-17), 11-10 | Atlanta-Fulton County Stadium (3-1) | 21-20 | Won 2 |
| » W: Steve Rosenberg (1-1) L: Jeff Parrett (0-1) | Fourth | 2 out |
| Friday, May 24 |
| » Lost to Astros (16-24), 1-0 | Astrodome (0-1) | 21-21 | |
| » W: Curt Schilling (1-3) L: Andy Benes (2-5) | Fourth | 3 out |
| Saturday, May 25 |
| » Defeated Astros (16-25), 4-2 | Astrodome (1-1) | 22-21 | |
| » W: Rich Rodriguez (2-1) L: Al Osuna (1-2) S: Craig Lefferts (10) | Third | 3 out |
| » Major-league debuts: Jose Mota (Padres) |
| Sunday, May 26 |
| » Lost to Astros (17-25), 13-3 | Astrodome (1-2) | 22-22 | |
| » W: Mark Portugal (5-1) L: Ed Whitson (3-5) | Fourth | 3 out |
| Monday, May 27 |
| » Lost to Braves (21-19), 3-1 | San Diego/Jack Murphy Stadium (7-13) | 22-23 | Lost 2 |
| » W: Steve Avery (6-2) L: Bruce Hurst (5-2) S: Juan Berenguer (5) | Fourth | 4 out |
| Tuesday, May 28 |
| » Lost to Braves (22-19), 8-6 | San Diego/Jack Murphy Stadium (7-14) | 22-24 | Lost 3 |
| » W: Mike Stanton (1-0) L: Craig Lefferts (0-2) S: Juan Berenguer (6) | Fourth | 5 out |
| Wednesday, May 29 |
| » Lost to Braves (23-19), 5-1 | San Diego/Jack Murphy Stadium (7-15) | 22-25 | Lost 4 |
| » W: Tom Glavine (8-2) L: Andy Benes (2-6) | Fourth | 5 out |
| Thursday, May 30 |
| » Defeated Astros (18-28), 4-0 | San Diego/Jack Murphy Stadium (8-15) | 23-25 | |
| » W: Dennis Rasmussen (1-0) L: Jimmy Jones (4-2) | Fourth | 4 out |
| Friday, May 31 |
| » Defeated Astros (18-29), 5-4 | San Diego/Jack Murphy Stadium (9-15) | 24-25 | Won 2 |
| » W: Jose Melendez (1-0) L: Mark Portugal (5-2) S: Craig Lefferts (11) | Fourth | 4 out |
| Saturday, June 1 |
| » Defeated Astros (18-30), 7-2 | San Diego/Jack Murphy Stadium (10-15) | 25-25 | Won 3 |
| » W: Bruce Hurst (6-2) L: Jim Deshaies (2-6) | Fourth | 3 out |
| Sunday, June 2 |
| » Defeated Astros (18-31), 3-1 | San Diego/Jack Murphy Stadium (11-15) | 26-25 | Won 4 |
| » W: Adam Peterson (2-1) L: Xavier Hernandez (0-6) S: Craig Lefferts (12) | Third | 3 out |
| Tuesday, June 4 |
| » Defeated Cubs (26-24), 7-1 | Wrigley Field (1-0) | 27-25 | Won 5 |
| » W: Andy Benes (3-6) L: Bob Scanlan (2-2) | Third | 2 out |
| Wednesday, June 5 |
| » Defeated Cubs (26-25), 3-0 | Wrigley Field (2-0) | 28-25 | Won 6 |
| » W: Dennis Rasmussen (2-0) L: Mike Bielecki (7-3) | Third | 2 out |
| Thursday, June 6 |
| » Lost to Cubs (27-25), 6-2 | Wrigley Field (2-1) | 28-26 | |
| » W: Greg Maddux (6-3) L: Jose Melendez (1-1) | Third | 3 out |
| » Major-league debuts: Rick Wilkins (Cubs) |
| Friday, June 7 |
| » Lost to Pirates (34-17), 1-0 | Three Rivers Stadium (0-1) | 28-27 | Lost 2 |
| » W: Doug Drabek (4-7) L: Bruce Hurst (6-3) S: Bill Landrum (10) | Third | 4 out |
| Saturday, June 8 |
| » Defeated Pirates (34-18), 11-0 | Three Rivers Stadium (1-1) | 29-27 | |
| » W: Mike Maddux (3-1) L: Randy Tomlin (3-2) | Third | 3 out |
| Sunday, June 9 |
| » Defeated Pirates (34-19), 5-3 | Three Rivers Stadium (2-1) | 30-27 | Won 2 |
| » W: Andy Benes (4-6) L: Zane Smith (7-4) S: Craig Lefferts (13) | Third | 3 out |
| Monday, June 10 |
| » Lost to Pirates (35-19), 5-3 | Three Rivers Stadium (2-2) | 30-28 | |
| » W: Vicente Palacios (4-2) L: Dennis Rasmussen (2-1) S: Bill Landrum (11) | Third | 4 out |
| Tuesday, June 11 |
| » Lost to Cardinals (30-26), 10-4 | San Diego/Jack Murphy Stadium (11-16) | 30-29 | Lost 2 |
| » W: Ken Hill (6-3) L: Jose Melendez (1-2) | Fourth | 4½ out |
| Wednesday, June 12 |
| » Defeated Cardinals (30-27), 7-2 | San Diego/Jack Murphy Stadium (12-16) | 31-29 | |
| » W: Bruce Hurst (7-3) L: Cris Carpenter (7-2) | Third | 3½ out |
| » Major-league debuts: Mark Grater (Cardinals) |
| Thursday, June 13 |
| » Lost to Cardinals (31-27), 12-1 | San Diego/Jack Murphy Stadium (12-17) | 31-30 | |
| » W: Bob Tewksbury (5-2) L: Atlee Hammaker (0-1) | Fourth | 4½ out |
| Friday, June 14 |
| » Lost to Cubs (31-29), 7-3 | San Diego/Jack Murphy Stadium (12-18) | 31-31 | Lost 2 |
| » W: Danny Jackson (1-2) L: Andy Benes (4-7) S: Dave Smith (16) | Fourth | 5½ out |
| Saturday, June 15 |
| » Defeated Cubs (31-30), 6-2 | San Diego/Jack Murphy Stadium (13-18) | 32-31 | |
| » W: Dennis Rasmussen (3-1) L: Mike Bielecki (8-5) | Fourth | 4½ out |
| Sunday, June 16 |
| » Defeated Cubs (31-31), 4-2 | San Diego/Jack Murphy Stadium (14-18) | 33-31 | Won 2 |
| » W: Jose Melendez (2-2) L: Greg Maddux (6-4) S: Larry Andersen (2) | Fourth | 4½ out |
| Monday, June 17 |
| » Lost to Pirates (38-22), 3-2 | San Diego/Jack Murphy Stadium (14-19) | 33-32 | |
| » W: Doug Drabek (6-7) L: Bruce Hurst (7-4) S: Vicente Palacios (2) | Fourth | 5½ out |
| Tuesday, June 18 |
| » Lost to Pirates (39-22), 3-1 | San Diego/Jack Murphy Stadium (14-20) | 33-33 | Lost 2 |
| » W: Bill Landrum (1-0) L: Craig Lefferts (0-3) | Fourth | 6½ out |
| Wednesday, June 19 |
| » Defeated Pirates (39-23), 6-5 | San Diego/Jack Murphy Stadium (15-20) | 34-33 | |
| » W: Larry Andersen (2-0) L: Neal Heaton (0-1) | Fourth | 6½ out |
| Friday, June 21 |
| » Lost to Cardinals (36-29), 4-3 | Busch Stadium II (0-1) | 34-34 | |
| » W: Juan Agosto (5-1) L: Larry Andersen (2-1) | Fourth | 7 out |
| Saturday, June 22 |
| » Defeated Cardinals (36-30), 4-3 | Busch Stadium II (1-1) | 35-34 | |
| » W: Jose Melendez (3-2) L: Ken Hill (6-5) S: Craig Lefferts (14) | Fourth | 7 out |
| Sunday, June 23 |
| » Defeated Cardinals (36-31), 3-2 | Busch Stadium II (2-1) | 36-34 | Won 2 |
| » W: Bruce Hurst (8-4) L: Juan Agosto (5-2) | Fourth | 7 out |
| Monday, June 24 |
| » Defeated Cardinals (36-32), 4-1 | Busch Stadium II (3-1) | 37-34 | Won 3 |
| » W: Adam Peterson (3-1) L: Bob Tewksbury (6-3) | Third | 6½ out |
| Tuesday, June 25 |
| » Lost to Reds (37-32), 8-2 | Riverfront Stadium (2-2) | 37-35 | |
| » W: Chris Hammond (5-5) L: Andy Benes (4-8) | Third | 6½ out |
| » Major-league debuts: Tim Scott (Padres) |
| Wednesday, June 26 |
| » Lost to Reds (38-32), 6-2 | Riverfront Stadium (2-3) | 37-36 | Lost 2 |
| » W: Scott Scudder (3-3) L: Dennis Rasmussen (3-2) S: Randy Myers (6) | Fourth | 6½ out |
| Thursday, June 27 |
| » Lost to Reds (39-32), 3-0 | Riverfront Stadium (2-4) | 37-37 | Lost 3 |
| » W: Jack Armstrong (5-6) L: Jose Melendez (3-3) S: Rob Dibble (20) | Fourth | 7 out |
| Friday, June 28 |
| » Defeated Giants (31-42), 5-3 | San Diego/Jack Murphy Stadium (16-20) | 38-37 | |
| » W: Bruce Hurst (9-4) L: Don Robinson (3-6) S: Larry Andersen (3) | Fourth | 6½ out |
| Saturday, June 29 |
| » Lost to Giants (32-42), 6-4 | San Diego/Jack Murphy Stadium (16-21) | 38-38 | |
| » W: Trevor Wilson (4-6) L: Ed Whitson (3-6) S: Dave Righetti (10) | Fourth | 7½ out |
| Sunday, June 30 |
| » Lost to Giants (33-42), 8-7 | San Diego/Jack Murphy Stadium (16-22) | 38-39 | Lost 2 |
| » W: Jeff Brantley (3-1) L: Craig Lefferts (0-4) | Fourth | 8½ out |
| Tuesday, July 2 |
| » Lost to Dodgers (46-29), 4-1 | San Diego/Jack Murphy Stadium (16-23) | 38-40 | Lost 3 |
| » W: Ramon Martinez (11-3) L: Dennis Rasmussen (3-3) S: Tim Crews (6) | Fourth | 9½ out |
| Wednesday, July 3 |
| » Lost to Dodgers (47-29), 6-3 | San Diego/Jack Murphy Stadium (16-24) | 38-41 | Lost 4 |
| » W: Bob Ojeda (7-5) L: Bruce Hurst (9-5) | Fourth | 10½ out |
| Thursday, July 4 |
| » Defeated Dodgers (47-30), 5-4 | San Diego/Jack Murphy Stadium (17-24) | 39-41 | |
| » W: Jose Melendez (4-3) L: Jim Gott (1-3) | Fourth | 9½ out |
| Friday, July 5 |
| » Defeated Giants (33-46), 4-2 | Candlestick Park (3-1) | 40-41 | Won 2 |
| » W: Ed Whitson (4-6) L: Mike Remlinger (2-1) S: Mike Maddux (2) | Fourth | 8½ out |
| Saturday, July 6 |
| » Lost to Giants (34-46), 4-1 | Candlestick Park (3-2) | 40-42 | |
| » W: Don Robinson (4-6) L: Andy Benes (4-9) S: Dave Righetti (11) | Fourth | 9½ out |
| Sunday, July 7 |
| » Lost to Giants (35-46), 3-0 | Candlestick Park (3-3) | 40-43 | Lost 2 |
| » W: John Burkett (5-5) L: Dennis Rasmussen (3-4) | Fourth | 10½ out |
| Thursday, July 11 |
| » Lost to Mets (47-34), 4-3 | Shea Stadium (1-2) | 40-44 | Lost 3 |
| » W: John Franco (2-6) L: Larry Andersen (2-2) | Fourth | 10½ out |
| Friday, July 12 |
| » Lost to Mets (48-34), 6-3 | Shea Stadium (1-3) | 40-45 | Lost 4 |
| » W: Frank Viola (11-5) L: Adam Peterson (3-2) S: Alejandro Pena (4) | Fourth | 10½ out |
| Saturday, July 13 |
| » Lost to Mets (49-34), 3-1 | Shea Stadium (1-4) | 40-46 | Lost 5 |
| » W: David Cone (9-5) L: Dennis Rasmussen (3-5) S: John Franco (20) | Fourth | 11 out |
| Sunday, July 14 |
| » Defeated Mets (49-35), 2-1 | Shea Stadium (2-4) | 41-46 | |
| » W: Greg Harris (2-1) L: Ron Darling (5-6) S: Craig Lefferts (15) | Fourth | 9½ out |
| Monday, July 15 |
| » Lost to Expos (40-47), 3-0 | Stade Olympique (2-2) | 41-47 | |
| » W: Chris Haney (1-3) L: Andy Benes (4-10) S: Jeff Fassero (3) | Fourth | 9½ out |
| Tuesday, July 16 |
| » Defeated Expos (40-48), 4-3 | Stade Olympique (3-2) | 42-47 | |
| » W: Bruce Hurst (10-5) L: Mel Rojas (0-1) S: Larry Andersen (4) | Fourth | 8½ out |
| Wednesday, July 17 |
| » Defeated Expos (40-49), 7-5 | Stade Olympique (4-2) | 43-47 | Won 2 |
| » W: Jose Melendez (5-3) L: Dennis Martinez (10-6) S: Larry Andersen (5) | Fourth | 7½ out |
| Friday, July 19 |
| » Lost to Phillies (39-51), 4-1 | San Diego/Jack Murphy Stadium (17-25) | 43-48 | |
| » W: Jose DeJesus (6-4) L: Dennis Rasmussen (3-6) S: Mitch Williams (18) | Fourth | 8 out |
| Saturday, July 20 |
| » Lost to Phillies (40-51), 4-0 | San Diego/Jack Murphy Stadium (17-26) | 43-49 | Lost 2 |
| » W: Bruce Ruffin (2-2) L: Greg Harris (2-2) | Fourth | 9 out |
| Sunday, July 21 |
| » Defeated Phillies (40-52), 5-2 | San Diego/Jack Murphy Stadium (18-26) | 44-49 | |
| » W: Bruce Hurst (11-5) L: Terry Mulholland (9-9) | Fourth | 8 out |
| Monday, July 22 |
| » Major-league debuts: Ryan Bowen (Astros) |
| Tuesday, July 23 |
| » Defeated Expos (41-52), 2-1 | San Diego/Jack Murphy Stadium (19-26) | 45-49 | Won 2 |
| » W: Larry Andersen (3-2) L: Dave Schmidt (0-1) | Fourth | 8 out |
| Wednesday, July 24 |
| » Lost to Expos (42-52), 8-2 | San Diego/Jack Murphy Stadium (19-27) | 45-50 | |
| » W: Brian Barnes (2-3) L: Dennis Rasmussen (3-7) S: Jeff Fassero (4) | Fourth | 9 out |
| Thursday, July 25 |
| » Defeated Expos (42-53), 6-5 | San Diego/Jack Murphy Stadium (20-27) | 46-50 | |
| » W: Mike Maddux (4-1) L: Barry Jones (3-7) | Fourth | 9 out |
| Friday, July 26 |
| » Defeated Mets (53-42), 8-2 | San Diego/Jack Murphy Stadium (21-27) | 47-50 | Won 2 |
| » W: Bruce Hurst (12-5) L: Sid Fernandez (0-1) | Fourth | 9 out |
| Saturday, July 27 |
| » Lost to Mets (54-42), 4-0 | San Diego/Jack Murphy Stadium (21-28) | 47-51 | |
| » W: Dwight Gooden (11-6) L: Adam Peterson (3-3) | Fourth | 10 out |
| Sunday, July 28 |
| » Defeated Mets (54-43), 2-0 | San Diego/Jack Murphy Stadium (22-28) | 48-51 | |
| » W: Andy Benes (5-10) L: Frank Viola (11-7) S: Craig Lefferts (16) | Fourth | 9 out |
| Tuesday, July 30 |
| » Lost to Phillies (41-58), 2-1 | Veteran's Stadium (1-4) | 48-52 | |
| » W: Jose DeJesus (7-4) L: Dennis Rasmussen (3-8) S: Mitch Williams (19) | Fifth | 9½ out |
| Wednesday, July 31 |
| » Lost to Phillies (42-58), 9-3 | Veteran's Stadium (1-5) | 48-53 | Lost 2 |
| » W: Bruce Ruffin (3-3) L: Greg Harris (2-3) | Fifth | 10½ out |
| Friday, August 2 |
| » Defeated Braves (53-47), 13-3 | Atlanta-Fulton County Stadium (4-1) | 49-53 | |
| » W: Bruce Hurst (13-5) L: Charlie Leibrandt (9-10) | Fifth | 9½ out |
| Saturday, August 3 |
| » Defeated Braves (53-48), 3-2 | Atlanta-Fulton County Stadium (5-1) | 50-53 | Won 2 |
| » W: Andy Benes (6-10) L: Tom Glavine (14-6) S: Larry Andersen (6) | Fifth | 8½ out |
| Sunday, August 4 |
| » Lost to Braves (54-48), 9-7 | Atlanta-Fulton County Stadium (5-2) | 50-54 | |
| » W: Steve Avery (12-5) L: Dennis Rasmussen (3-9) S: Juan Berenguer (16) | Fifth | 8½ out |
| Monday, August 5 |
| » Lost to Astros (45-59), 2-1 | Astrodome (1-3) | 50-55 | Lost 2 |
| » W: Dwayne Henry (3-0) L: Larry Andersen (3-3) | Fifth | 8½ out |
| Tuesday, August 6 |
| » Lost to Astros (46-59), 6-1 | Astrodome (1-4) | 50-56 | Lost 3 |
| » W: Darryl Kile (5-6) L: Adam Peterson (3-4) S: Al Osuna (8) | Fifth | 9½ out |
| Wednesday, August 7 |
| » Defeated Astros (46-60), 7-4 | Astrodome (2-4) | 51-56 | |
| » W: Bruce Hurst (14-5) L: Dean Wilkins (2-1) S: Larry Andersen (7) | Fifth | 9½ out |
| Thursday, August 8 |
| » Defeated Astros (46-61), 5-3 | Astrodome (3-4) | 52-56 | Won 2 |
| » W: Andy Benes (7-10) L: Ryan Bowen (1-2) S: Craig Lefferts (17) | Fifth | 9½ out |
| » Major-league debuts: Tony Eusebio (Astros) |
| Friday, August 9 |
| » Lost to Reds (53-54), 5-1 | San Diego/Jack Murphy Stadium (22-29) | 52-57 | |
| » W: Mo Sanford (1-0) L: Dennis Rasmussen (3-10) | Fifth | 9½ out |
| » Major-league debuts: Jim Lewis (Padres) Mo Sanford (Reds) |
| Saturday, August 10 |
| » Defeated Reds (53-55), 1-0 | San Diego/Jack Murphy Stadium (23-29) | 53-57 | |
| » W: Greg Harris (3-3) L: Jose Rijo (8-3) | Fifth | 8½ out |
| Sunday, August 11 |
| » Defeated Reds (53-56), 13-0 | San Diego/Jack Murphy Stadium (24-29) | 54-57 | Won 2 |
| » W: Ricky Bones (1-0) L: Kip Gross (4-4) | Fifth | 7½ out |
| » Major-league debuts: Ricky Bones (Padres) |
| Monday, August 12 |
| » Defeated Astros (46-65), 6-5 | San Diego/Jack Murphy Stadium (25-29) | 55-57 | Won 3 |
| » W: Jose Melendez (6-3) L: Mike Capel (1-3) S: Craig Lefferts (18) | Fourth | 7½ out |
| Tuesday, August 13 |
| » Lost to Astros (47-65), 12-9 | San Diego/Jack Murphy Stadium (25-30) | 55-58 | |
| » W: Ryan Bowen (2-2) L: Mike Maddux (4-2) S: Al Osuna (9) | Fourth | 7½ out |
| Wednesday, August 14 |
| » Defeated Astros (47-66), 4-1 | San Diego/Jack Murphy Stadium (26-30) | 56-58 | |
| » W: Dennis Rasmussen (4-10) L: Jim Deshaies (4-10) S: Larry Andersen (8) | Fourth | 7½ out |
| Thursday, August 15 |
| » Defeated Braves (61-52), 1-0 | San Diego/Jack Murphy Stadium (27-30) | 57-58 | Won 2 |
| » W: Greg Harris (4-3) L: John Smoltz (8-13) | Fourth | 6½ out |
| Friday, August 16 |
| » Lost to Braves (62-52), 3-2 | San Diego/Jack Murphy Stadium (27-31) | 57-59 | |
| » W: Armando Reynoso (2-0) L: Ricky Bones (1-1) S: Mike Stanton (4) | Fourth | 7½ out |
| Saturday, August 17 |
| » Lost to Braves (63-52), 2-1 | San Diego/Jack Murphy Stadium (27-32) | 57-60 | Lost 2 |
| » W: Charlie Leibrandt (11-11) L: Bruce Hurst (14-6) S: Mark Wohlers (1) | Fifth | 8½ out |
| » Major-league debuts: Mark Wohlers (Braves) |
| Sunday, August 18 |
| » Defeated Braves (63-53), 2-1 | San Diego/Jack Murphy Stadium (28-32) | 58-60 | |
| » W: Andy Benes (8-10) L: Tom Glavine (15-8) S: Larry Andersen (9) | Third | 7½ out |
| Monday, August 19 |
| » Lost to Dodgers (66-52), 3-2 | Dodger Stadium (3-1) | 58-61 | |
| » W: Kevin Gross (8-9) L: Larry Andersen (3-4) | Fifth | 8½ out |
| Tuesday, August 20 |
| » Lost to Dodgers (67-52), 6-4 | Dodger Stadium (3-2) | 58-62 | Lost 2 |
| » W: Ramon Martinez (15-8) L: Greg Harris (4-4) S: Jay Howell (13) | Fourth | 9½ out |
| Wednesday, August 21 |
| » Lost to Dodgers (68-52), 9-5 | Dodger Stadium (3-3) | 58-63 | Lost 3 |
| » W: Orel Hershiser (5-2) L: Ricky Bones (1-2) | Fourth | 10½ out |
| Friday, August 23 |
| » Lost to Cubs (62-59), 5-4 | Wrigley Field (2-2) | 58-64 | Lost 4 |
| » W: Les Lancaster (9-7) L: Craig Lefferts (0-5) | Fourth | 10½ out |
| Saturday, August 24 |
| » Defeated Cubs (62-60), 4-1 | Wrigley Field (3-2) | 59-64 | |
| » W: Andy Benes (9-10) L: Greg Maddux (10-8) S: Jose Melendez (1) | Fourth | 9½ out |
| Sunday, August 25 |
| » Defeated Cubs (62-61), 12-9 | Wrigley Field (4-2) | 60-64 | Won 2 |
| » W: Mike Maddux (5-2) L: Bob Scanlan (5-7) S: Jose Melendez (2) | Fourth | 8½ out |
| Monday, August 26 |
| » Defeated Pirates (72-51), 7-5 | Three Rivers Stadium (3-2) | 61-64 | Won 3 |
| » W: Craig Lefferts (1-5) L: Bill Landrum (1-4) | Fourth | 8½ out |
| Tuesday, August 27 |
| » Lost to Pirates (73-51), 5-2 | Three Rivers Stadium (3-3) | 61-65 | |
| » W: Zane Smith (12-9) L: Ricky Bones (1-3) S: Roger Mason (1) | Third | 8½ out |
| Wednesday, August 28 |
| » Defeated Cardinals (69-56), 2-1 | Busch Stadium II (4-1) | 62-65 | |
| » W: Bruce Hurst (15-6) L: Scott Terry (4-2) S: Craig Lefferts (19) | Fourth | 8½ out |
| Thursday, August 29 |
| » Defeated Cardinals (69-57), 1-0 | Busch Stadium II (5-1) | 63-65 | Won 2 |
| » W: Andy Benes (10-10) L: Omar Olivares (7-5) | Fourth | 8½ out |
| Friday, August 30 |
| » Lost to Pirates (76-51), 4-1 | San Diego/Jack Murphy Stadium (28-33) | 63-66 | |
| » W: John Smiley (16-8) L: Dennis Rasmussen (4-11) S: Rosario Rodriguez (1) | Fourth | 9½ out |
| Saturday, August 31 |
| » Lost to Pirates (77-51), 3-2 | San Diego/Jack Murphy Stadium (28-34) | 63-67 | Lost 2 |
| » W: Bill Landrum (2-4) L: Jose Melendez (6-4) S: Bob Kipper (3) | Fourth | 9½ out |
| Sunday, September 1 |
| » Defeated Pirates (77-52), 7-4 | San Diego/Jack Murphy Stadium (29-34) | 64-67 | |
| » W: Ricky Bones (2-3) L: Zane Smith (12-10) S: Mike Maddux (3) | Third | 8½ out |
| Monday, September 2 |
| » Lost to Cubs (66-65), 10-8 | San Diego/Jack Murphy Stadium (29-35) | 64-68 | |
| » W: Chuck McElroy (6-2) L: Jose Melendez (6-5) | Third | 8½ out |
| » Major-league debuts: Jeremy Hernandez (Padres) |
| Tuesday, September 3 |
| » Defeated Cubs (66-66), 4-1 | San Diego/Jack Murphy Stadium (30-35) | 65-68 | |
| » W: Andy Benes (11-10) L: Greg Maddux (11-9) | Third | 8½ out |
| Wednesday, September 4 |
| » Defeated Cubs (66-67), 5-1 | San Diego/Jack Murphy Stadium (31-35) | 66-68 | Won 2 |
| » W: Dennis Rasmussen (5-11) L: Danny Jackson (1-5) | Fourth | 8½ out |
| Thursday, September 5 |
| » Defeated Cardinals (71-62), 3-1 | San Diego/Jack Murphy Stadium (32-35) | 67-68 | Won 3 |
| » W: Greg Harris (5-4) L: Scott Terry (4-4) S: Jose Melendez (3) | Fourth | 8 out |
| Friday, September 6 |
| » Defeated Cardinals (71-63), 6-2 | San Diego/Jack Murphy Stadium (33-35) | 68-68 | Won 4 |
| » W: Ricky Bones (3-3) L: Bob Tewksbury (9-10) | Third | 7½ out |
| » Major-league debuts: Mark Clark (Cardinals) |
| Saturday, September 7 |
| » Defeated Cardinals (71-64), 1-0 | San Diego/Jack Murphy Stadium (34-35) | 69-68 | Won 5 |
| » W: Mike Maddux (6-2) L: Cris Carpenter (10-4) | Third | 7½ out |
| Sunday, September 8 |
| » Major-league debuts: Rey Sanchez (Cubs) |
| Monday, September 9 |
| » Defeated Astros (57-80), 3-0 | Astrodome (4-4) | 70-68 | Won 6 |
| » W: Andy Benes (12-10) L: Mark Portugal (10-8) S: Craig Lefferts (20) | Third | 8 out |
| Tuesday, September 10 |
| » Defeated Astros (57-81), 7-6 | Astrodome (5-4) | 71-68 | Won 7 |
| » W: Dennis Rasmussen (6-11) L: Chris Gardner (0-1) S: Craig Lefferts (21) | Third | 7½ out |
| » Major-league debuts: Chris Gardner (Astros) |
| Wednesday, September 11 |
| » Lost to Braves (79-60), 1-0 | Atlanta-Fulton County Stadium (5-3) | 71-69 | |
| » W: Kent Mercker (5-3) L: Greg Harris (5-5) S: Alejandro Pena (8) | Third | 8½ out |
| » Major-league debuts: Rico Rossy (Braves) |
| Thursday, September 12 |
| » Lost to Braves (80-60), 5-1 | Atlanta-Fulton County Stadium (5-4) | 71-70 | Lost 2 |
| » W: Charlie Leibrandt (15-11) L: Bruce Hurst (15-7) | Third | 9½ out |
| Friday, September 13 |
| » Defeated Giants (64-77), 13-2 | Candlestick Park (4-3) | 72-70 | |
| » W: Ricky Bones (4-3) L: Trevor Wilson (10-10) | Third | 9 out |
| Saturday, September 14 |
| » Defeated Giants (64-78), 3-1 | Candlestick Park (5-3) | 73-70 | Won 2 |
| » W: Andy Benes (13-10) L: Gil Heredia (0-1) S: Mike Maddux (4) | Third | 8½ out |
| Sunday, September 15 |
| » Lost to Giants (65-78), 7-2 | Candlestick Park (5-4) | 73-71 | |
| » W: John Burkett (10-10) L: Dennis Rasmussen (6-12) | Third | 9½ out |
| Monday, September 16 |
| » Defeated Astros (58-86), 6-1 | San Diego/Jac |