| Saturday, January 19 |
| Former Indian Roy Weatherly dies in Woodville, TX at the age of 76. |
| Friday, January 25 |
| Former Indian Hoot Evers dies in Houston, TX at the age of 70. |
| Tuesday, February 26 |
| Former Indian Jimmy Zinn dies in Memphis, TN at the age of 97. |
| Monday, April 8 |
| » Lost to Royals (1-0), 4-2 | Royals Stadium (0-1) | 0-1 | |
| » W: Bret Saberhagen (1-0) L: Greg Swindell (0-1) S: Jeff Montgomery (1) | Second | 1 out |
| Tuesday, April 9 |
| » Defeated Royals (1-1), 2-1 | Royals Stadium (1-1) | 1-1 | |
| » W: Tom Candiotti (1-0) L: Mike Boddicker (0-1) S: Doug Jones (1) | Second | ½ out |
| Wednesday, April 10 |
| » Lost to Royals (2-1), 1-0 | Royals Stadium (1-2) | 1-2 | |
| » W: Kevin Appier (1-0) L: Charles Nagy (0-1) S: Jeff Montgomery (2) | Fourth | 1½ out |
| Thursday, April 11 |
| » Defeated Red Sox (1-3), 6-4 | Fenway Park (1-0) | 2-2 | |
| » W: Eric King (1-0) L: Danny Darwin (0-1) S: Doug Jones (2) | Third | 1 out |
| Saturday, April 13 |
| » Lost to Red Sox (2-3), 4-0 | Fenway Park (1-1) | 2-3 | |
| » W: Roger Clemens (2-0) L: Greg Swindell (0-2) | Fourth | 1½ out |
| » Major-league debuts: Bruce Egloff and Jose Escobar (Indians) |
| Sunday, April 14 |
| » Defeated Red Sox (2-4), 6-0 | Fenway Park (2-1) | 3-3 | |
| » W: Tom Candiotti (2-0) L: Greg Harris (0-2) | Second | 1½ out |
| Monday, April 15 |
| » Defeated Red Sox (2-5), 1-0 | Fenway Park (3-1) | 4-3 | Won 2 |
| » W: Steve Olin (1-0) L: Dennis Lamp (0-1) S: Doug Jones (3) | Second | 1½ out |
| Tuesday, April 16 |
| » Lost to Rangers (2-4), 3-1 | Cleveland Stadium (0-1) | 4-4 | |
| » W: Kevin Brown (1-1) L: Eric King (1-1) S: Jeff Russell (1) | Third | 1½ out |
| Thursday, April 18 |
| » Lost to Rangers (3-4), 7-0 | Cleveland Stadium (0-2) | 4-5 | Lost 2 |
| » W: Bobby Witt (1-1) L: Greg Swindell (0-3) | Fourth | 1½ out |
| Saturday, April 20 |
| » Lost to Red Sox (6-5), 2-1 | Cleveland Stadium (0-3) | 4-6 | Lost 3 |
| » W: Greg Harris (1-2) L: Tom Candiotti (2-1) S: Jeff Reardon (3) | Fifth | 3 out |
| Sunday, April 21 |
| Former Indian Dick Weik dies in Harvey, IL at the age of 64. |
| Monday, April 22 |
| » Defeated Royals (5-7), 10-4 | Cleveland Stadium (1-3) | 5-6 | |
| » W: Charles Nagy (1-1) L: Kevin Appier (1-2) | Fourth | 1½ out |
| » Major-league debuts: Mike Magnante (Royals) |
| Tuesday, April 23 |
| » Lost to Royals (6-7), 6-0 | Cleveland Stadium (1-4) | 5-7 | |
| » W: Storm Davis (2-1) L: Eric King (1-2) | Fifth | 2½ out |
| Wednesday, April 24 |
| » Lost to Royals (7-7), 4-2 | Cleveland Stadium (1-5) | 5-8 | Lost 2 |
| » W: Jeff Montgomery (1-0) L: Doug Jones (0-1) | Fifth | 2½ out |
| Friday, April 26 |
| » Defeated Rangers (6-7), 5-2 | Arlington Stadium (1-0) | 6-8 | |
| » W: Steve Olin (2-0) L: Nolan Ryan (2-2) S: Doug Jones (4) | Fifth | 3 out |
| » Major-league debuts: Mark Lewis (Indians) |
| Former Indian Nate Andrews dies in Winston-Salem, NC at the age of 78. |
| Saturday, April 27 |
| » Lost to Rangers (7-7), 4-1 | Arlington Stadium (1-1) | 6-9 | |
| » W: Mike Jeffcoat (1-0) L: Steve Olin (2-1) S: Jeff Russell (4) | Fifth | 3 out |
| Sunday, April 28 |
| » Defeated Rangers (7-8), 4-2 | Arlington Stadium (2-1) | 7-9 | |
| » W: Eric King (2-2) L: Bobby Witt (1-2) S: Doug Jones (5) | Fifth | 3 out |
| Tuesday, April 30 |
| » Lost to Angels (10-10), 6-5 | Anaheim Stadium (0-1) | 7-10 | |
| » W: Bryan Harvey (1-0) L: Doug Jones (0-2) | Fourth | 3½ out |
| Wednesday, May 1 |
| » Defeated Angels (10-11), 5-1 | Anaheim Stadium (1-1) | 8-10 | |
| » W: Tom Candiotti (3-1) L: Chuck Finley (4-1) | Fourth | 2½ out |
| Friday, May 3 |
| » Lost to Athletics (15-7), 4-3 | Oakland-Alameda County Stadium (0-1) | 8-11 | |
| » W: Joe Klink (1-1) L: Steve Olin (2-2) | Fifth | 3½ out |
| Saturday, May 4 |
| » Defeated Athletics (15-8), 20-6 | Oakland-Alameda County Stadium (1-1) | 9-11 | |
| » W: Eric King (3-2) L: Kirk Dressendorfer (2-2) | Fifth | 3½ out |
| Sunday, May 5 |
| » Defeated Athletics (15-9), 15-6 | Oakland-Alameda County Stadium (2-1) | 10-11 | Won 2 |
| » W: Greg Swindell (1-3) L: Bob Welch (3-2) | Fifth | 3½ out |
| Tuesday, May 7 |
| » Lost to Mariners (14-13), 7-6 | Kingdome (0-1) | 10-12 | |
| » W: Mike Jackson (2-2) L: Doug Jones (0-3) | Fifth | 3½ out |
| Wednesday, May 8 |
| » Lost to Mariners (15-13), 6-2 | Kingdome (0-2) | 10-13 | Lost 2 |
| » W: Brian Holman (3-3) L: Charles Nagy (1-2) S: Bill Swift (2) | Fifth | 4½ out |
| Friday, May 10 |
| » Lost to Angels (14-14), 12-2 | Cleveland Stadium (1-6) | 10-14 | Lost 3 |
| » W: Mark Langston (3-1) L: Eric King (3-3) | Fifth | 6 out |
| Saturday, May 11 |
| » Lost to Angels (15-14), 2-1 | Cleveland Stadium (1-7) | 10-15 | Lost 4 |
| » W: Jim Abbott (2-4) L: Greg Swindell (1-4) S: Bryan Harvey (8) | Fifth | 7 out |
| Sunday, May 12 |
| » Defeated Angels (15-15), 4-1 | Cleveland Stadium (2-7) | 11-15 | |
| » W: Tom Candiotti (4-1) L: Scott Lewis (1-3) | Fifth | 6 out |
| Monday, May 13 |
| » Lost to Angels (16-15), 9-5 | Cleveland Stadium (2-8) | 11-16 | |
| » W: Chuck Finley (6-1) L: Steve Olin (2-3) S: Jeff Robinson (2) | Fifth | 6 out |
| Tuesday, May 14 |
| » Lost to Mariners (18-14), 2-1 | Cleveland Stadium (2-9) | 11-17 | Lost 2 |
| » W: Brian Holman (4-3) L: Rod Nichols (0-1) S: Bill Swift (3) | Sixth | 7 out |
| Wednesday, May 15 |
| » Lost to Mariners (19-14), 6-4 | Cleveland Stadium (2-10) | 11-18 | Lost 3 |
| » W: Rich DeLucia (4-2) L: Eric King (3-4) S: Bill Swift (4) | Sixth | 8 out |
| Thursday, May 16 |
| » Lost to Mariners (20-14), 3-1 | Cleveland Stadium (2-11) | 11-19 | Lost 4 |
| » W: Mike Jackson (4-2) L: Greg Swindell (1-5) | Sixth | 8½ out |
| Friday, May 17 |
| » Defeated Athletics (20-14), 11-6 | Cleveland Stadium (3-11) | 12-19 | |
| » W: Tom Candiotti (5-1) L: Mike Moore (5-2) | Fourth | 7½ out |
| » Major-league debuts: Ever Magallanes (Indians) Catfish Hunter (Athletics) |
| Saturday, May 18 |
| » Lost to Athletics (21-14), 3-0 | Cleveland Stadium (3-12) | 12-20 | |
| » W: Andy Hawkins (1-2) L: Charles Nagy (1-3) S: Dennis Eckersley (10) | Fourth | 7½ out |
| » Major-league debuts: Eddie Taubensee (Indians) |
| Sunday, May 19 |
| » Lost to Athletics (22-14), 9-4 | Cleveland Stadium (3-13) | 12-21 | Lost 2 |
| » W: Curt Young (2-1) L: Rod Nichols (0-2) | Fifth | 7½ out |
| Monday, May 20 |
| » Defeated Yankees (13-22), 3-1 | Cleveland Stadium (4-13) | 13-21 | |
| » W: Eric King (4-4) L: Chuck Cary (1-5) S: Shawn Hillegas (1) | Fifth | 7½ out |
| » Major-league debuts: Pat Kelly (Yankees) |
| Tuesday, May 21 |
| » Defeated Yankees (13-23), 5-2 | Cleveland Stadium (5-13) | 14-21 | Won 2 |
| » W: Greg Swindell (2-5) L: Dave Eiland (1-3) | Fifth | 7½ out |
| Wednesday, May 22 |
| » Lost to Yankees (14-23), 8-1 | Cleveland Stadium (5-14) | 14-22 | |
| » W: Tim Leary (3-3) L: Tom Candiotti (5-2) | Fifth | 8½ out |
| Thursday, May 23 |
| » Lost to Brewers (18-21), 7-3 | County Stadium (0-1) | 14-23 | Lost 2 |
| » W: Don August (3-2) L: Charles Nagy (1-4) S: Darren Holmes (2) | Fifth | 8½ out |
| » Major-league debuts: Matias Carrillo (Brewers) |
| Friday, May 24 |
| » Lost to Brewers (19-21), 1-0 | County Stadium (0-2) | 14-24 | Lost 3 |
| » W: Jaime Navarro (4-2) L: Rod Nichols (0-3) | Sixth | 9½ out |
| Saturday, May 25 |
| » Defeated Brewers (19-22), 5-4 | County Stadium (1-2) | 15-24 | |
| » W: Doug Jones (1-3) L: Julio Machado (0-1) | Sixth | 8½ out |
| Sunday, May 26 |
| » Lost to Brewers (20-22), 7-6 | County Stadium (1-3) | 15-25 | |
| » W: Chuck Crim (3-1) L: Doug Jones (1-4) | Sixth | 8½ out |
| Monday, May 27 |
| » Defeated Orioles (13-28), 3-2 | Memorial Stadium (1-0) | 16-25 | |
| » W: Tom Candiotti (6-2) L: Bob Milacki (1-2) S: Shawn Hillegas (2) | Sixth | 7½ out |
| Tuesday, May 28 |
| » Lost to Orioles (14-28), 5-2 | Memorial Stadium (1-1) | 16-26 | |
| » W: Roy Smith (1-0) L: Charles Nagy (1-5) S: Gregg Olson (6) | Sixth | 8½ out |
| Former Indian Roy Cullenbine dies in Mt.Clemens, MI at the age of 78. |
| Wednesday, May 29 |
| » Lost to Orioles (15-28), 2-1 | Memorial Stadium (1-2) | 16-27 | Lost 2 |
| » W: Jeff Robinson (3-4) L: Mike Walker (0-1) S: Gregg Olson (7) | Sixth | 8½ out |
| Friday, May 31 |
| » Defeated Tigers (23-23), 11-9 | Cleveland Stadium (6-14) | 17-27 | |
| » W: Sergio Valdez (1-0) L: Kevin Ritz (0-1) S: Shawn Hillegas (3) | Sixth | 8 out |
| » Major-league debuts: Mike Dalton (Tigers) |
| Saturday, June 1 |
| » Defeated Tigers (23-24), 3-1 | Cleveland Stadium (7-14) | 18-27 | Won 2 |
| » W: Greg Swindell (3-5) L: Bill Gullickson (5-3) | Fifth | 7 out |
| Sunday, June 2 |
| » Defeated Tigers (23-25), 3-2 | Cleveland Stadium (8-14) | 19-27 | Won 3 |
| » W: Tom Candiotti (7-2) L: Frank Tanana (2-5) S: Doug Jones (6) | Fifth | 6 out |
| Monday, June 3 |
| » Defeated Tigers (23-26), 2-0 | Cleveland Stadium (9-14) | 20-27 | Won 4 |
| » W: Charles Nagy (2-5) L: Walt Terrell (2-6) S: Shawn Hillegas (4) | Sixth | 6 out |
| Tuesday, June 4 |
| » Lost to White Sox (23-25), 4-1 | Cleveland Stadium (9-15) | 20-28 | |
| » W: Jack McDowell (6-3) L: Rod Nichols (0-4) | Sixth | 6 out |
| Wednesday, June 5 |
| » Defeated White Sox (23-26), 2-1 | Cleveland Stadium (10-15) | 21-28 | |
| » W: Shawn Hillegas (1-0) L: Ramon Garcia (0-1) | Sixth | 6 out |
| Thursday, June 6 |
| » Lost to White Sox (24-26), 2-1 | Cleveland Stadium (10-16) | 21-29 | |
| » W: Melido Perez (2-4) L: Doug Jones (1-5) S: Bobby Thigpen (11) | Sixth | 6 out |
| Friday, June 7 |
| » Lost to Twins (29-25), 2-0 | Hubert H. Humphrey Metrodome (0-1) | 21-30 | Lost 2 |
| » W: Allan Anderson (3-4) L: Tom Candiotti (7-3) S: Rick Aguilera (14) | Sixth | 6 out |
| Saturday, June 8 |
| » Lost to Twins (30-25), 2-1 | Hubert H. Humphrey Metrodome (0-2) | 21-31 | Lost 3 |
| » W: Scott Erickson (9-2) L: Charles Nagy (2-6) S: Rick Aguilera (15) | Sixth | 7 out |
| Sunday, June 9 |
| » Lost to Twins (31-25), 9-2 | Hubert H. Humphrey Metrodome (0-3) | 21-32 | Lost 4 |
| » W: Jack Morris (7-5) L: Rod Nichols (0-5) | Sixth | 8 out |
| Monday, June 10 |
| » Lost to Twins (32-25), 8-5 | Hubert H. Humphrey Metrodome (0-4) | 21-33 | Lost 5 |
| » W: Paul Abbott (1-0) L: Eric King (4-5) S: Rick Aguilera (16) | Sixth | 8½ out |
| Tuesday, June 11 |
| » Defeated Blue Jays (31-27), 2-1 | Cleveland Stadium (11-16) | 22-33 | |
| » W: Shawn Hillegas (2-0) L: Jim Acker (1-4) | Sixth | 7½ out |
| Wednesday, June 12 |
| » Lost to Blue Jays (32-27), 1-0 | Cleveland Stadium (11-17) | 22-34 | |
| » W: Mike Timlin (5-3) L: Tom Candiotti (7-4) S: Tom Henke (9) | Sixth | 8½ out |
| Thursday, June 13 |
| » Lost to Blue Jays (33-27), 1-0 | Cleveland Stadium (11-18) | 22-35 | Lost 2 |
| » W: Jimmy Key (10-2) L: Charles Nagy (2-7) | Sixth | 9½ out |
| Friday, June 14 |
| » Lost to Twins (36-25), 7-0 | Cleveland Stadium (11-19) | 22-36 | Lost 3 |
| » W: Jack Morris (8-5) L: Jeff Shaw (0-1) | Sixth | 10½ out |
| Saturday, June 15 |
| » Lost to Twins (37-25), 11-7 | Cleveland Stadium (11-20) | 22-37 | Lost 4 |
| » W: Paul Abbott (2-0) L: Jeff Mutis (0-1) | Sixth | 10½ out |
| » Major-league debuts: Jeff Mutis (Indians) |
| Sunday, June 16 |
| » Lost to Twins (38-25), 4-2 | Cleveland Stadium (11-21) | 22-38 | Lost 5 |
| » W: Rick Aguilera (2-2) L: Shawn Hillegas (2-1) | Sixth | 11 out |
| Tuesday, June 18 |
| » Lost to White Sox (30-31), 6-5 | Comiskey Park II (0-1) | 22-39 | Lost 6 |
| » W: Charlie Hough (4-3) L: Tom Candiotti (7-5) S: Bobby Thigpen (13) | Seventh | 10½ out |
| Wednesday, June 19 |
| » Defeated White Sox (30-32), 4-3 | Comiskey Park II (1-1) | 23-39 | |
| » W: Charles Nagy (3-7) L: Greg Hibbard (4-6) S: Rod Nichols (1) | Sixth | 9½ out |
| Friday, June 21 |
| » Lost to Blue Jays (36-31), 8-4 | Skydome (0-1) | 23-40 | |
| » W: David Wells (8-4) L: Greg Swindell (3-6) S: Tom Henke (10) | Sixth | 11 out |
| Saturday, June 22 |
| » Lost to Blue Jays (37-31), 4-0 | Skydome (0-2) | 23-41 | Lost 2 |
| » W: Juan Guzman (1-2) L: Jeff Mutis (0-2) S: Duane Ward (13) | Seventh | 12 out |
| Sunday, June 23 |
| » Lost to Blue Jays (38-31), 3-1 | Skydome (0-3) | 23-42 | Lost 3 |
| » W: Rob MacDonald (1-0) L: Tom Candiotti (7-6) S: Tom Henke (11) | Seventh | 13 out |
| Monday, June 24 |
| » Lost to Blue Jays (39-31), 4-3 | Skydome (0-4) | 23-43 | Lost 4 |
| » W: Duane Ward (1-3) L: Charles Nagy (3-8) S: Tom Henke (12) | Seventh | 14 out |
| Tuesday, June 25 |
| » Lost to Orioles (27-41), 5-3 | Cleveland Stadium (11-22) | 23-44 | Lost 5 |
| » W: Mark Williamson (2-2) L: Doug Jones (1-6) S: Gregg Olson (13) | Seventh | 14 out |
| Wednesday, June 26 |
| » Defeated Orioles (27-42), 10-4 | Cleveland Stadium (12-22) | 24-44 | |
| » W: Greg Swindell (4-6) L: Jeff Ballard (4-8) S: Jeff Shaw (1) | Seventh | 14 out |
| Thursday, June 27 |
| » Lost to Orioles (28-42), 7-2 | Cleveland Stadium (12-23) | 24-45 | |
| » W: Bob Milacki (4-2) L: Jeff Mutis (0-3) S: Gregg Olson (14) | Seventh | 15 out |
| Friday, June 28 |
| » Lost to Tigers (35-37), 7-1 | Tiger Stadium (0-1) | 24-46 | Lost 2 |
| » W: Frank Tanana (5-6) L: Denis Boucher (0-4) | Seventh | 15 out |
| Saturday, June 29 |
| » Lost to Tigers (36-37), 9-4 | Tiger Stadium (0-2) | 24-47 | Lost 3 |
| » W: Rusty Meacham (1-0) L: Charles Nagy (3-9) S: Mike Henneman (11) | Seventh | 16 out |
| » Major-league debuts: Rusty Meacham (Tigers) |
| Sunday, June 30 |
| » Lost to Tigers (37-37), 4-1 | Tiger Stadium (0-3) | 24-48 | Lost 4 |
| » W: Walt Terrell (4-8) L: Rod Nichols (0-6) S: Mark Leiter (1) | Seventh | 17 out |
| Monday, July 1 |
| » Lost to Yankees (34-38), 6-2 | Yankee Stadium (0-1) | 24-49 | Lost 5 |
| » W: Scott Sanderson (9-3) L: Greg Swindell (4-7) S: Lee Guetterman (4) | Seventh | 18 out |
| Tuesday, July 2 |
| » Lost to Yankees (35-38), 8-5 | Yankee Stadium (0-2) | 24-50 | Lost 6 |
| » W: Wade Taylor (4-2) L: Mike York (0-1) S: Steve Farr (11) | Seventh | 19 out |
| Wednesday, July 3 |
| » Lost to Yankees (36-38), 3-2 | Yankee Stadium (0-3) | 24-51 | Lost 7 |
| » W: Scott Kamieniecki (3-1) L: Denis Boucher (0-5) S: Steve Farr (12) | Seventh | 20 out |
| Thursday, July 4 |
| » Defeated Brewers (34-43), 3-0 | Cleveland Stadium (13-23) | 25-51 | |
| » W: Charles Nagy (4-9) L: Jim Hunter (0-2) | Seventh | 19 out |
| » Major-league debuts: Jim Austin (Brewers) |
| Friday, July 5 |
| » Lost to Brewers (35-43), 4-2 | Cleveland Stadium (13-24) | 25-52 | |
| » W: Bill Wegman (4-3) L: Rod Nichols (0-7) S: Dan Plesac (6) | Seventh | 20 out |
| Saturday, July 6 |
| » Defeated Brewers (35-44), 2-0 | Cleveland Stadium (14-24) | 26-52 | |
| » Manager: Mike Hargrove |
| » W: Greg Swindell (5-7) L: Jaime Navarro (7-6) S: Shawn Hillegas (5) | Seventh | 20 out |
| Sunday, July 7 |
| » Lost to Brewers (36-44), 10-6 | Cleveland Stadium (14-25) | 26-53 | |
| » W: Chuck Crim (5-4) L: Jeff Shaw (0-2) S: Dan Plesac (7) | Seventh | 21 out |
| Thursday, July 11 |
| » Lost to Mariners (41-42), 6-0 | Kingdome (0-3) | 26-54 | Lost 2 |
| » W: Brian Holman (8-9) L: Charles Nagy (4-10) S: Bill Swift (7) | Seventh | 22 out |
| Friday, July 12 |
| » Lost to Mariners (42-42), 7-0 | Kingdome (0-4) | 26-55 | Lost 3 |
| » W: Randy Johnson (7-6) L: Rod Nichols (0-8) | Seventh | 23 out |
| Saturday, July 13 |
| » Defeated Mariners (42-43), 6-3 | Kingdome (1-4) | 27-55 | |
| » W: Greg Swindell (6-7) L: Mike Jackson (4-4) | Seventh | 23 out |
| Sunday, July 14 |
| » Lost to Mariners (43-43), 14-3 | Kingdome (1-5) | 27-56 | |
| » W: Rich DeLucia (8-5) L: Mike York (0-2) | Seventh | 23 out |
| Monday, July 15 |
| » Lost to Athletics (47-40), 6-1 | Oakland-Alameda County Stadium (2-2) | 27-57 | Lost 2 |
| » W: Andy Hawkins (4-5) L: Denis Boucher (0-6) | Seventh | 24 out |
| Tuesday, July 16 |
| » Lost to Athletics (48-40), 7-6 | Oakland-Alameda County Stadium (2-3) | 27-58 | Lost 3 |
| » W: Joe Klink (6-2) L: Doug Jones (1-7) | Seventh | 24 out |
| Wednesday, July 17 |
| » Defeated Athletics (48-41), 2-1 | Oakland-Alameda County Stadium (3-3) | 28-58 | |
| » W: Rod Nichols (1-8) L: Bob Welch (8-6) | Seventh | 23½ out |
| Thursday, July 18 |
| » Lost to Angels (47-41), 5-4 | Anaheim Stadium (1-2) | 28-59 | |
| » W: Bryan Harvey (2-3) L: Shawn Hillegas (2-2) | Seventh | 24½ out |
| Friday, July 19 |
| » Defeated Angels (47-42), 4-2 | Anaheim Stadium (2-2) | 29-59 | |
| » W: Jesse Orosco (1-0) L: Mark Eichhorn (2-2) S: Steve Olin (1) | Seventh | 24½ out |
| Saturday, July 20 |
| » Defeated Angels (47-43), 4-1 | Anaheim Stadium (3-2) | 30-59 | Won 2 |
| » W: Denis Boucher (1-6) L: Kirk McCaskill (7-12) S: Steve Olin (2) | Seventh | 23½ out |
| » Major-league debuts: Chris Beasley (Angels) |
| Sunday, July 21 |
| » Defeated Angels (47-44), 5-2 | Anaheim Stadium (4-2) | 31-59 | Won 3 |
| » W: Charles Nagy (5-10) L: Mark Langston (13-4) S: Steve Olin (3) | Seventh | 22½ out |
| Tuesday, July 23 |
| » Lost to Athletics (50-44), 10-7 | Cleveland Stadium (14-26) | 31-60 | |
| » W: Rick Honeycutt (1-2) L: Jeff Shaw (0-3) | Seventh | 22½ out |
| Wednesday, July 24 |
| » Lost to Athletics (51-44), 8-4 | Cleveland Stadium (14-27) | 31-61 | Lost 2 |
| » W: Eric Show (1-2) L: Greg Swindell (6-8) | Seventh | 23½ out |
| Thursday, July 25 |
| » Defeated Athletics (51-45), 8-7 | Cleveland Stadium (15-27) | 32-61 | |
| » W: Mike York (1-2) L: Dennis Eckersley (1-2) S: Steve Olin (4) | Seventh | 22½ out |
| Friday, July 26 |
| » Lost to Mariners (51-46), 7-4 | Cleveland Stadium (15-28) | 32-62 | |
| » W: Rich DeLucia (9-6) L: Denis Boucher (1-7) S: Mike Schooler (1) | Seventh | 23½ out |
| Saturday, July 27 |
| » Defeated Mariners (51-47), 6-1 | Cleveland Stadium (16-28) | 33-62 | |
| » W: Charles Nagy (6-10) L: Brian Holman (9-10) | Seventh | 22½ out |
| Sunday, July 28 |
| » Lost to Mariners (52-47), 6-5 | Cleveland Stadium (16-29) | 33-63 | |
| » W: Randy Johnson (9-7) L: Mike York (1-3) S: Bill Swift (9) | Seventh | 22½ out |
| Monday, July 29 |
| » Lost to Angels (51-47), 10-2 | Cleveland Stadium (16-30) | 33-64 | Lost 2 |
| » W: Chuck Finley (14-5) L: Greg Swindell (6-9) | Seventh | 22½ out |
| Tuesday, July 30 |
| » Lost to Angels (52-47), 4-2 | Cleveland Stadium (16-31) | 33-65 | Lost 3 |
| » W: Kirk McCaskill (8-13) L: Dave Otto (0-1) S: Bryan Harvey (25) | Seventh | 22½ out |
| Wednesday, July 31 |
| » Lost to Blue Jays (58-44), 3-1 | Skydome (0-5) | 33-66 | Lost 4 |
| » W: Jimmy Key (11-6) L: Eric King (4-6) S: Tom Henke (21) | Seventh | 23½ out |
| Thursday, August 1 |
| » Lost to Blue Jays (59-44), 7-5 | Skydome (0-6) | 33-67 | Lost 5 |
| » W: Duane Ward (4-3) L: Jeff Shaw (0-4) S: Tom Henke (22) | Seventh | 24½ out |
| Friday, August 2 |
| » Lost to Royals (51-50), 6-4 | Cleveland Stadium (16-32) | 33-68 | Lost 6 |
| » W: Kevin Appier (8-7) L: Rod Nichols (1-9) S: Jeff Montgomery (22) | Seventh | 24½ out |
| Saturday, August 3 |
| » Defeated Royals (51-51), 3-1 | Cleveland Stadium (17-32) | 34-68 | |
| » W: Greg Swindell (7-9) L: Tom Gordon (7-10) | Seventh | 23½ out |
| Sunday, August 4 |
| » Lost to Royals (52-51), 2-0 | Cleveland Stadium (17-33) | 34-69 | |
| » W: Bret Saberhagen (8-5) L: Dave Otto (0-2) | Seventh | 24½ out |
| Monday, August 5 |
| » Defeated Rangers (54-48), 9-0 | Arlington Stadium (3-1) | 35-69 | |
| » W: Eric King (5-6) L: Kevin Brown (7-9) | Seventh | 24 out |
| Tuesday, August 6 |
| » Lost to Rangers (55-48), 10-8 | Arlington Stadium (3-2) | 35-70 | |
| » W: Kenny Rogers (7-7) L: Mike York (1-4) S: Jeff Russell (21) | Seventh | 25 out |
| Wednesday, August 7 |
| » Lost to Rangers (56-48), 12-10 | Arlington Stadium (3-3) | 35-71 | Lost 2 |
| » W: Mike Jeffcoat (5-2) L: Shawn Hillegas (2-3) S: Jeff Russell (22) | Seventh | 26 out |
| Friday, August 9 |
| » Lost to Royals (56-51), 4-2 | Royals Stadium (1-3) | 35-72 | Lost 3 |
| » W: Mark Gubicza (7-5) L: Greg Swindell (7-10) S: Jeff Montgomery (23) | Seventh | 25½ out |
| Former Indian Hank Majeski dies in Staten Island, NY at the age of 75. |
| Saturday, August 10 |
| » Defeated Royals (56-52), 1-0 | Royals Stadium (2-3) | 36-72 | |
| » W: Dave Otto (1-2) L: Bret Saberhagen (8-6) S: Steve Olin (5) | Seventh | 24½ out |
| » Major-league debuts: Harvey Pulliam (Royals) |
| Sunday, August 11 |
| » Lost to Royals (57-52), 3-2 | Royals Stadium (2-4) | 36-73 | |
| » W: Tom Gordon (8-10) L: Steve Olin (2-4) | Seventh | 24½ out |
| Tuesday, August 13 |
| » Defeated Red Sox (54-58), 8-6 | Cleveland Stadium (18-33) | 37-73 | |
| » W: Shawn Hillegas (3-3) L: Dana Kiecker (2-3) S: Steve Olin (6) | Seventh | 23½ out |
| » Lost to Red Sox (55-58), 7-5 | Cleveland Stadium (18-34) | 37-74 | |
| » W: Tony Fossas (2-2) L: Rod Nichols (1-10) S: Jeff Reardon (29) | Seventh | 23½ out |
| Wednesday, August 14 |
| » Lost to Red Sox (56-58), 2-1 | Cleveland Stadium (18-35) | 37-75 | Lost 2 |
| » W: Joe Hesketh (7-2) L: Greg Swindell (7-11) S: Jeff Reardon (30) | Seventh | 23½ out |
| Thursday, August 15 |
| » Lost to Red Sox (57-58), 6-2 | Cleveland Stadium (18-36) | 37-76 | Lost 3 |
| » W: Mike Gardiner (5-6) L: Dave Otto (1-3) | Seventh | 24½ out |
| Friday, August 16 |
| » Lost to Rangers (58-55), 5-3 | Cleveland Stadium (18-37) | 37-77 | Lost 4 |
| » W: Kevin Brown (8-9) L: Eric King (5-7) S: Jeff Russell (23) | Seventh | 24 out |
| » Defeated Rangers (58-56), 13-9 | Cleveland Stadium (19-37) | 38-77 | |
| » W: Jesse Orosco (2-0) L: Mike Jeffcoat (5-3) | Seventh | 24 out |
| Saturday, August 17 |
| » Lost to Rangers (59-56), 2-0 | Cleveland Stadium (19-38) | 38-78 | |
| » W: Jose Guzman (8-5) L: Willie Blair (0-1) S: Jeff Russell (24) | Seventh | 25 out |
| Sunday, August 18 |
| » Lost to Rangers (60-56), 9-4 | Cleveland Stadium (19-39) | 38-79 | Lost 2 |
| » W: Brian Bohanon (2-0) L: Charles Nagy (6-11) S: Wayne Rosenthal (1) | Seventh | 26 out |
| Wednesday, August 21 |
| » Lost to Red Sox (60-59), 13-5 | Fenway Park (3-2) | 38-80 | Lost 3 |
| » W: Joe Hesketh (8-2) L: Greg Swindell (7-12) | Seventh | 27 out |
| » Lost to Red Sox (61-59), 5-4 | Fenway Park (3-3) | 38-81 | Lost 4 |
| » W: Greg Harris (9-11) L: Steve Olin (2-5) | Seventh | 27 out |
| Thursday, August 22 |
| » Lost to Red Sox (62-59), 7-6 | Fenway Park (3-4) | 38-82 | Lost 5 |
| » W: Greg Harris (10-11) L: Steve Olin (2-6) | Seventh | 27 out |
| Friday, August 23 |
| » Defeated White Sox (67-55), 4-3 | Cleveland Stadium (20-39) | 39-82 | |
| » W: Willie Blair (1-1) L: Greg Hibbard (8-10) S: Shawn Hillegas (6) | Seventh | 27 out |
| Saturday, August 24 |
| » Defeated White Sox (67-56), 2-1 | Cleveland Stadium (21-39) | 40-82 | Won 2 |
| » W: Charles Nagy (7-11) L: Jack McDowell (14-8) S: Steve Olin (7) | Sixth | 26 out |
| Sunday, August 25 |
| » Defeated White Sox (67-57), 3-0 | Cleveland Stadium (22-39) | 41-82 | Won 3 |
| » W: Rod Nichols (2-10) L: Alex Fernandez (6-11) | Sixth | 26 out |
| Monday, August 26 |
| » Lost to Twins (76-51), 5-3 | Cleveland Stadium (22-40) | 41-83 | |
| » W: Kevin Tapani (12-7) L: Dave Otto (1-4) S: Rick Aguilera (34) | Sixth | 27 out |
| Tuesday, August 27 |
| » Defeated Twins (76-52), 2-1 | Cleveland Stadium (23-40) | 42-83 | |
| » W: Greg Swindell (8-12) L: Jack Morris (15-10) S: Steve Olin (8) | Seventh | 27 out |
| Wednesday, August 28 |
| » Lost to Twins (77-52), 4-2 | Cleveland Stadium (23-41) | 42-84 | |
| » W: David West (4-3) L: Eric King (5-8) S: Rick Aguilera (35) | Seventh | 28 out |
| Thursday, August 29 |
| » Lost to White Sox (68-60), 7-2 | Comiskey Park II (1-2) | 42-85 | Lost 2 |
| » W: Jack McDowell (15-8) L: Willie Blair (1-2) | Seventh | 29 out |
| Friday, August 30 |
| » Defeated White Sox (68-61), 3-2 | Comiskey Park II (2-2) | 43-85 | |
| » W: Charles Nagy (8-11) L: Alex Fernandez (6-12) S: Steve Olin (9) | Seventh | 28 out |
| Saturday, August 31 |
| » Lost to White Sox (69-61), 10-5 | Comiskey Park II (2-3) | 43-86 | |
| » W: Donn Pall (6-2) L: Dave Otto (1-5) S: Scott Radinsky (5) | Seventh | 29 out |
| Sunday, September 1 |
| » Lost to White Sox (70-61), 6-1 | Comiskey Park II (2-4) | 43-87 | Lost 2 |
| » W: Wilson Alvarez (2-2) L: Greg Swindell (8-13) | Seventh | 29 out |
| Monday, September 2 |
| » Lost to Twins (80-53), 9-3 | Hubert H. Humphrey Metrodome (0-5) | 43-88 | Lost 3 |
| » W: Scott Erickson (17-6) L: Eric King (5-9) S: Rick Aguilera (37) | Seventh | 30 out |
| Tuesday, September 3 |
| » Major-league debuts: Esteban Beltre and Tom Drees (White Sox) |
| Wednesday, September 4 |
| » Defeated Twins (80-54), 8-4 | Hubert H. Humphrey Metrodome (1-5) | 44-88 | |
| » W: Willie Blair (2-2) L: David West (4-4) S: Shawn Hillegas (7) | Seventh | 29½ out |
| » Major-league debuts: Jim Thome (Indians) |
| Thursday, September 5 |
| » Lost to Blue Jays (76-60), 13-1 | Cleveland Stadium (23-42) | 44-89 | |
| » W: Jimmy Key (15-9) L: Charles Nagy (8-12) | Seventh | 30½ out |
| » Major-league debuts: Vince Horsman and Randy Knorr (Blue Jays) |
| Friday, September 6 |
| » Lost to Blue Jays (77-60), 7-4 | Cleveland Stadium (23-43) | 44-90 | Lost 2 |
| » W: Juan Guzman (6-2) L: Dave Otto (1-6) S: Duane Ward (19) | Seventh | 31½ out |
| Saturday, September 7 |
| » Lost to Blue Jays (78-60), 4-1 | Cleveland Stadium (23-44) | 44-91 | Lost 3 |
| » W: Tom Candiotti (12-11) L: Greg Swindell (8-14) | Seventh | 32½ out |
| Sunday, September 8 |
| » Lost to Blue Jays (79-60), 11-5 | Cleveland Stadium (23-45) | 44-92 | Lost 4 |
| » W: David Wells (14-10) L: Eric King (5-10) | Seventh | 33½ out |
| Monday, September 9 |
| » Lost to Red Sox (73-64), 4-3 | Cleveland Stadium (23-46) | 44-93 | Lost 5 |
| » W: Greg Harris (11-11) L: Shawn Hillegas (3-4) S: Jeff Reardon (37) | Seventh | 34 out |
| » Major-league debuts: Garland Kiser (Indians) |
| Tuesday, September 10 |
| » Defeated Brewers (65-72), 5-2 | County Stadium (2-3) | 45-93 | |
| » W: Doug Jones (2-7) L: Bill Wegman (11-7) S: Steve Olin (10) | Seventh | 33 out |
| Thursday, September 12 |
|