| Monday, April 8 |
| » Major-league debuts: Mike Timlin (Blue Jays) |
| Tuesday, April 9 |
| » Defeated Cubs (0-1), 4-1 | Wrigley Field (1-0) | 1-0 | |
| » W: Bryn Smith (1-0) L: Danny Jackson (0-1) S: Lee Smith (1) | Second | ½ out |
| » Major-league debuts: Gary Scott (Cubs) |
| Wednesday, April 10 |
| » Lost to Cubs (1-1), 2-0 | Wrigley Field (1-1) | 1-1 | |
| » W: Greg Maddux (1-0) L: Jose DeLeon (0-1) S: Dave Smith (1) | Second | ½ out |
| Thursday, April 11 |
| » Defeated Cubs (1-2), 5-4 | Wrigley Field (2-1) | 2-1 | |
| » W: Ken Hill (1-0) L: Mike Harkey (0-1) S: Lee Smith (2) | Second | ½ out |
| » Major-league debuts: Heathcliff Slocumb (Cubs) |
| Former Cardinal Walker Cooper dies in Scottsdale, AZ at the age of 77. |
| Friday, April 12 |
| » Lost to Phillies (2-2), 11-4 | Veteran's Stadium (0-1) | 2-2 | |
| » W: Pat Combs (1-0) L: Jamie Moyer (0-1) | Third | 1 out |
| Saturday, April 13 |
| » Lost to Phillies (3-2), 4-2 | Veteran's Stadium (0-2) | 2-3 | Lost 2 |
| » W: Terry Mulholland (1-1) L: Bob Tewksbury (0-1) S: Mitch Williams (2) | Third | 1½ out |
| Sunday, April 14 |
| » Defeated Phillies (3-3), 11-7 | Veteran's Stadium (1-2) | 3-3 | |
| » W: Bryn Smith (2-0) L: Dave LaPoint (0-1) S: Lee Smith (3) | Second | 1½ out |
| Monday, April 15 |
| » Defeated Expos (2-6), 5-4 | Stade Olympique (1-0) | 4-3 | Won 2 |
| » W: Cris Carpenter (1-0) L: Tim Burke (1-1) S: Lee Smith (4) | Second | 1½ out |
| Tuesday, April 16 |
| » Lost to Expos (3-6), 4-1 | Stade Olympique (1-1) | 4-4 | |
| » W: Rick Mahler (1-1) L: Ken Hill (1-1) S: Tim Burke (1) | Third | 1½ out |
| Wednesday, April 17 |
| » Lost to Expos (4-6), 1-0 | Stade Olympique (1-2) | 4-5 | Lost 2 |
| » W: Bill Sampen (1-0) L: Jamie Moyer (0-2) S: Barry Jones (1) | Fourth | 2 out |
| Friday, April 19 |
| » Defeated Phillies (3-7), 3-1 | Busch Stadium II (1-0) | 5-5 | |
| » W: Bob Tewksbury (1-1) L: Terry Mulholland (1-2) S: Lee Smith (5) | Third | 1½ out |
| Saturday, April 20 |
| » Lost to Phillies (4-7), 6-5 | Busch Stadium II (1-1) | 5-6 | |
| » W: Roger McDowell (2-0) L: Cris Carpenter (1-1) S: Mitch Williams (3) | Second | 1 out |
| » Defeated Phillies (4-8), 12-1 | Busch Stadium II (2-1) | 6-6 | |
| » W: Jose DeLeon (1-1) L: Jason Grimsley (0-2) S: Omar Olivares (1) | Second | 1 out |
| Sunday, April 21 |
| » Defeated Phillies (4-9), 7-6 | Busch Stadium II (3-1) | 7-6 | Won 2 |
| » W: Lee Smith (1-0) L: Mitch Williams (0-2) | Second | 1 out |
| Monday, April 22 |
| » Defeated Cubs (7-7), 3-2 | Busch Stadium II (4-1) | 8-6 | Won 3 |
| » W: Juan Agosto (1-0) L: Dave Smith (0-2) | Second | ½ out |
| Tuesday, April 23 |
| » Defeated Cubs (7-8), 4-2 | Busch Stadium II (5-1) | 9-6 | Won 4 |
| » W: Bob Tewksbury (2-1) L: Rick Sutcliffe (1-1) S: Lee Smith (6) | Second | ½ out |
| Wednesday, April 24 |
| » Lost to Cubs (8-8), 1-0 | Busch Stadium II (5-2) | 9-7 | |
| » W: Mike Bielecki (3-1) L: Jose DeLeon (1-2) S: Paul Assenmacher (2) | Second | 1½ out |
| Friday, April 26 |
| » Defeated Expos (5-12), 4-0 | Busch Stadium II (6-2) | 10-7 | |
| » W: Bryn Smith (3-0) L: Oil Can Boyd (0-3) S: Juan Agosto (1) | Second | 1 out |
| Former Cardinal Nate Andrews dies in Winston-Salem, NC at the age of 78. |
| Saturday, April 27 |
| » Defeated Expos (5-13), 2-1 | Busch Stadium II (7-2) | 11-7 | Won 2 |
| » W: Ken Hill (2-1) L: Rick Mahler (1-2) S: Lee Smith (7) | Second | 1 out |
| Sunday, April 28 |
| » Lost to Expos (6-13), 9-6 | Busch Stadium II (7-3) | 11-8 | |
| » W: Tim Burke (2-1) L: Mike Perez (0-1) | Second | 2 out |
| Monday, April 29 |
| » Defeated Braves (8-9), 4-3 | Busch Stadium II (8-3) | 12-8 | |
| » W: Lee Smith (2-0) L: Doug Sisk (2-1) | Second | 1½ out |
| Tuesday, April 30 |
| » Defeated Braves (8-10), 5-3 | Busch Stadium II (9-3) | 13-8 | Won 2 |
| » W: Cris Carpenter (2-1) L: Charlie Leibrandt (2-2) S: Lee Smith (8) | Second | ½ out |
| Wednesday, May 1 |
| » Lost to Braves (9-10), 5-4 | Busch Stadium II (9-4) | 13-9 | |
| » W: Kent Mercker (1-1) L: Mike Perez (0-2) | Second | 1½ out |
| Friday, May 3 |
| » Defeated Reds (11-10), 4-2 | Riverfront Stadium (1-0) | 14-9 | |
| » W: Cris Carpenter (3-1) L: Scott Scudder (0-2) S: Lee Smith (9) | Second | 1½ out |
| Saturday, May 4 |
| » Lost to Reds (12-10), 3-1 | Riverfront Stadium (1-1) | 14-10 | |
| » W: Jack Armstrong (2-1) L: Jamie Moyer (0-3) S: Rob Dibble (6) | Third | 1½ out |
| Sunday, May 5 |
| » Lost to Reds (13-10), 4-2 | Riverfront Stadium (1-2) | 14-11 | Lost 2 |
| » W: Tom Browning (4-1) L: Lee Smith (2-1) S: Rob Dibble (7) | Third | 1½ out |
| Tuesday, May 7 |
| » Lost to Braves (12-11), 9-2 | Atlanta-Fulton County Stadium (0-1) | 14-12 | Lost 3 |
| » W: Steve Avery (3-1) L: Bryn Smith (3-1) | Third | 3 out |
| Wednesday, May 8 |
| » Lost to Braves (13-11), 17-1 | Atlanta-Fulton County Stadium (0-2) | 14-13 | Lost 4 |
| » W: Tom Glavine (4-2) L: Ken Hill (2-2) | Third | 4 out |
| Friday, May 10 |
| » Defeated Astros (11-16), 7-5 | Astrodome (1-0) | 15-13 | |
| » W: Juan Agosto (2-0) L: Curt Schilling (0-2) S: Lee Smith (10) | Third | 4 out |
| Saturday, May 11 |
| » Lost to Astros (12-16), 6-1 | Astrodome (1-1) | 15-14 | |
| » W: Mark Portugal (4-1) L: Jose DeLeon (1-3) | Third | 4 out |
| Sunday, May 12 |
| » Defeated Astros (12-17), 7-3 | Astrodome (2-1) | 16-14 | |
| » W: Cris Carpenter (4-1) L: Al Osuna (1-1) | Third | 3 out |
| Monday, May 13 |
| » Defeated Reds (15-15), 1-0 | Busch Stadium II (10-4) | 17-14 | Won 2 |
| » W: Ken Hill (3-2) L: Randy Myers (0-3) S: Lee Smith (11) | Third | 2½ out |
| Tuesday, May 14 |
| » Lost to Reds (16-15), 3-1 | Busch Stadium II (10-5) | 17-15 | |
| » W: Norm Charlton (2-3) L: Jamie Moyer (0-4) S: Rob Dibble (9) | Third | 3½ out |
| » Major-league debuts: Freddie Benavides (Reds) |
| Wednesday, May 15 |
| » Defeated Reds (16-16), 8-2 | Busch Stadium II (11-5) | 18-15 | |
| » W: Bob Tewksbury (3-1) L: Tom Browning (4-3) | Third | 3½ out |
| Friday, May 17 |
| » Lost to Astros (13-20), 5-4 | Busch Stadium II (11-6) | 18-16 | |
| » W: Jim Deshaies (1-4) L: Lee Smith (2-2) S: Al Osuna (1) | Third | 4 out |
| Saturday, May 18 |
| » Defeated Astros (13-21), 12-2 | Busch Stadium II (12-6) | 19-16 | |
| » W: Bryn Smith (4-1) L: Xavier Hernandez (0-3) | Third | 3½ out |
| Sunday, May 19 |
| » Defeated Astros (13-22), 9-2 | Busch Stadium II (13-6) | 20-16 | Won 2 |
| » W: Ken Hill (4-2) L: Pete Harnisch (2-3) | Third | 2½ out |
| Tuesday, May 21 |
| » Lost to Pirates (23-13), 5-3 | Three Rivers Stadium (0-1) | 20-17 | |
| » W: John Smiley (6-1) L: Jamie Moyer (0-5) S: Bill Landrum (6) | Third | 3½ out |
| Wednesday, May 22 |
| » Defeated Pirates (23-14), 5-3 | Three Rivers Stadium (1-1) | 21-17 | |
| » W: Cris Carpenter (5-1) L: Doug Drabek (2-7) S: Lee Smith (12) | Third | 2½ out |
| Thursday, May 23 |
| » Defeated Pirates (23-15), 8-2 | Three Rivers Stadium (2-1) | 22-17 | Won 2 |
| » W: Jose DeLeon (2-3) L: Randy Tomlin (3-1) S: Scott Terry (1) | Second | 1½ out |
| Friday, May 24 |
| » Lost to Mets (22-17), 6-2 | Shea Stadium (0-1) | 22-18 | |
| » W: David Cone (4-3) L: Bryn Smith (4-2) | Third | 2½ out |
| Saturday, May 25 |
| » Defeated Mets (22-18), 7-2 | Shea Stadium (1-1) | 23-18 | |
| » W: Ken Hill (5-2) L: Wally Whitehurst (2-2) | Second | 2½ out |
| Sunday, May 26 |
| » Defeated Mets (22-19), 14-4 | Shea Stadium (2-1) | 24-18 | Won 2 |
| » W: Cris Carpenter (6-1) L: Dwight Gooden (5-4) | Second | 2½ out |
| Monday, May 27 |
| » Lost to Pirates (27-15), 8-0 | Busch Stadium II (13-7) | 24-19 | |
| » W: Doug Drabek (3-7) L: Bob Tewksbury (3-2) | Second | 3½ out |
| Tuesday, May 28 |
| » Lost to Pirates (28-15), 9-8 | Busch Stadium II (13-8) | 24-20 | Lost 2 |
| » W: Stan Belinda (3-1) L: Jose DeLeon (2-4) S: Bill Landrum (8) | Third | 4½ out |
| Wednesday, May 29 |
| » Lost to Pirates (29-15), 6-0 | Busch Stadium II (13-9) | 24-21 | Lost 3 |
| » W: Zane Smith (7-2) L: Bryn Smith (4-3) | Third | 5½ out |
| Friday, May 31 |
| » Lost to Mets (26-19), 10-5 | Busch Stadium II (13-10) | 24-22 | Lost 4 |
| » W: Wally Whitehurst (3-2) L: Juan Agosto (2-1) | Third | 6½ out |
| Saturday, June 1 |
| » Defeated Mets (26-20), 6-5 | Busch Stadium II (14-10) | 25-22 | |
| » W: Juan Agosto (3-1) L: John Franco (1-4) | Third | 6½ out |
| Sunday, June 2 |
| » Defeated Mets (26-21), 3-1 | Busch Stadium II (15-10) | 26-22 | Won 2 |
| » W: Bob Tewksbury (4-2) L: Ron Darling (2-3) S: Lee Smith (13) | Third | 6½ out |
| Tuesday, June 4 |
| » Defeated Dodgers (28-22), 3-2 | Busch Stadium II (16-10) | 27-22 | Won 3 |
| » W: Lee Smith (3-2) L: Jim Gott (0-1) | Third | 5½ out |
| Wednesday, June 5 |
| » Lost to Dodgers (29-22), 2-0 | Busch Stadium II (16-11) | 27-23 | |
| » W: Ramon Martinez (9-2) L: Bryn Smith (4-4) | Third | 6½ out |
| Thursday, June 6 |
| » Lost to Dodgers (30-22), 1-0 | Busch Stadium II (16-12) | 27-24 | Lost 2 |
| » W: Bob Ojeda (5-4) L: Ken Hill (5-3) S: Tim Crews (3) | Third | 6½ out |
| Friday, June 7 |
| » Lost to Giants (21-33), 5-2 | Busch Stadium II (16-13) | 27-25 | Lost 3 |
| » W: Don Robinson (3-4) L: Omar Olivares (0-1) S: Dave Righetti (5) | Third | 7½ out |
| Saturday, June 8 |
| » Defeated Giants (21-34), 3-2 | Busch Stadium II (17-13) | 28-25 | |
| » W: Cris Carpenter (7-1) L: Francisco Oliveras (1-2) | Third | 6½ out |
| Sunday, June 9 |
| » Lost to Giants (22-34), 3-2 | Busch Stadium II (17-14) | 28-26 | |
| » W: John Burkett (4-3) L: Jose DeLeon (2-5) S: Jeff Brantley (5) | Third | 6½ out |
| Monday, June 10 |
| » Defeated Giants (22-35), 3-2 | Busch Stadium II (18-14) | 29-26 | |
| » W: Scott Terry (1-0) L: Jose Segura (0-1) S: Lee Smith (14) | Third | 6½ out |
| Tuesday, June 11 |
| » Defeated Padres (30-29), 10-4 | San Diego/Jack Murphy Stadium (1-0) | 30-26 | Won 2 |
| » W: Ken Hill (6-3) L: Jose Melendez (1-2) | Third | 6 out |
| Wednesday, June 12 |
| » Lost to Padres (31-29), 7-2 | San Diego/Jack Murphy Stadium (1-1) | 30-27 | |
| » W: Bruce Hurst (7-3) L: Cris Carpenter (7-2) | Third | 7 out |
| » Major-league debuts: Mark Grater (Cardinals) |
| Thursday, June 13 |
| » Defeated Padres (31-30), 12-1 | San Diego/Jack Murphy Stadium (2-1) | 31-27 | |
| » W: Bob Tewksbury (5-2) L: Atlee Hammaker (0-1) | Second | 6 out |
| Friday, June 14 |
| » Lost to Dodgers (35-24), 2-1 | Dodger Stadium (0-1) | 31-28 | |
| » W: Jay Howell (1-2) L: Scott Terry (1-1) | Second | 6 out |
| Saturday, June 15 |
| » Defeated Dodgers (35-25), 5-4 | Dodger Stadium (1-1) | 32-28 | |
| » W: Bryn Smith (5-4) L: Ramon Martinez (10-3) S: Lee Smith (15) | Second | 5 out |
| Sunday, June 16 |
| » Lost to Dodgers (36-25), 7-2 | Dodger Stadium (1-2) | 32-29 | |
| » W: Bob Ojeda (6-4) L: Ken Hill (6-4) | Second | 6 out |
| Monday, June 17 |
| » Defeated Giants (25-39), 5-4 | Candlestick Park (1-0) | 33-29 | |
| » W: Juan Agosto (4-1) L: Dave Righetti (2-3) S: Lee Smith (16) | Second | 6 out |
| Tuesday, June 18 |
| » Defeated Giants (25-40), 3-1 | Candlestick Park (2-0) | 34-29 | Won 2 |
| » W: Bob Tewksbury (6-2) L: Trevor Wilson (2-6) S: Lee Smith (17) | Second | 6 out |
| Wednesday, June 19 |
| » Defeated Giants (25-41), 3-2 | Candlestick Park (3-0) | 35-29 | Won 3 |
| » W: Jose DeLeon (3-5) L: John Burkett (4-4) S: Lee Smith (18) | Second | 5 out |
| Friday, June 21 |
| » Defeated Padres (34-34), 4-3 | Busch Stadium II (19-14) | 36-29 | Won 4 |
| » W: Juan Agosto (5-1) L: Larry Andersen (2-1) | Second | 4½ out |
| Saturday, June 22 |
| » Lost to Padres (35-34), 4-3 | Busch Stadium II (19-15) | 36-30 | |
| » W: Jose Melendez (3-2) L: Ken Hill (6-5) S: Craig Lefferts (14) | Second | 4½ out |
| Sunday, June 23 |
| » Lost to Padres (36-34), 3-2 | Busch Stadium II (19-16) | 36-31 | Lost 2 |
| » W: Bruce Hurst (8-4) L: Juan Agosto (5-2) | Second | 4½ out |
| Monday, June 24 |
| » Lost to Padres (37-34), 4-1 | Busch Stadium II (19-17) | 36-32 | Lost 3 |
| » W: Adam Peterson (3-1) L: Bob Tewksbury (6-3) | Second | 5 out |
| Tuesday, June 25 |
| » Defeated Phillies (30-40), 10-9 | Busch Stadium II (20-17) | 37-32 | |
| » W: Scott Terry (2-1) L: Roger McDowell (3-5) S: Lee Smith (19) | Second | 4 out |
| Wednesday, June 26 |
| » Defeated Phillies (30-41), 14-1 | Busch Stadium II (21-17) | 38-32 | Won 2 |
| » W: Bryn Smith (6-4) L: Pat Combs (2-6) | Second | 4 out |
| Thursday, June 27 |
| » Defeated Phillies (30-42), 4-2 | Busch Stadium II (22-17) | 39-32 | Won 3 |
| » W: Ken Hill (7-5) L: Tommy Greene (5-1) S: Lee Smith (20) | Second | 4 out |
| Friday, June 28 |
| » Defeated Cubs (32-41), 14-6 | Wrigley Field (3-1) | 40-32 | Won 4 |
| » W: Omar Olivares (1-1) L: Bob Scanlan (2-3) | Second | 4 out |
| Saturday, June 29 |
| » Lost to Cubs (33-41), 6-4 | Wrigley Field (3-2) | 40-33 | |
| » W: Les Lancaster (4-2) L: Bob Tewksbury (6-4) S: Paul Assenmacher (6) | Second | 5 out |
| Sunday, June 30 |
| » Lost to Cubs (34-41), 7-4 | Wrigley Field (3-3) | 40-34 | Lost 2 |
| » W: Chuck McElroy (4-0) L: Jose DeLeon (3-6) | Second | 6 out |
| Monday, July 1 |
| » Defeated Phillies (32-44), 1-0 | Veteran's Stadium (2-2) | 41-34 | |
| » W: Bryn Smith (7-4) L: Bruce Ruffin (1-1) S: Lee Smith (21) | Second | 5 out |
| Tuesday, July 2 |
| » Defeated Phillies (32-45), 6-1 | Veteran's Stadium (3-2) | 42-34 | Won 2 |
| » W: Ken Hill (8-5) L: Tommy Greene (5-2) S: Lee Smith (22) | Second | 5 out |
| Wednesday, July 3 |
| » Defeated Phillies (32-46), 4-3 | Veteran's Stadium (4-2) | 43-34 | Won 3 |
| » W: Omar Olivares (2-1) L: Jose DeJesus (5-4) S: Lee Smith (23) | Second | 5 out |
| Thursday, July 4 |
| » Lost to Phillies (33-46), 7-1 | Veteran's Stadium (4-3) | 43-35 | |
| » W: Terry Mulholland (7-8) L: Bob Tewksbury (6-5) | Third | 5 out |
| Friday, July 5 |
| » Lost to Cubs (37-43), 5-1 | Busch Stadium II (22-18) | 43-36 | Lost 2 |
| » W: Frank Castillo (1-0) L: Jose DeLeon (3-7) | Third | 5 out |
| Saturday, July 6 |
| » Lost to Cubs (38-43), 12-2 | Busch Stadium II (22-19) | 43-37 | Lost 3 |
| » W: Mike Bielecki (9-6) L: Bryn Smith (7-5) | Third | 5 out |
| Sunday, July 7 |
| » Defeated Cubs (38-44), 8-7 | Busch Stadium II (23-19) | 44-37 | |
| » W: Willie Fraser (1-2) L: Laddie Renfroe (0-1) | Third | 5 out |
| Thursday, July 11 |
| » Lost to Braves (40-40), 4-1 | Atlanta-Fulton County Stadium (0-3) | 44-38 | |
| » W: Steve Avery (9-5) L: Jose DeLeon (3-8) S: Juan Berenguer (13) | Third | 6 out |
| Friday, July 12 |
| » Lost to Braves (41-40), 6-2 | Atlanta-Fulton County Stadium (0-4) | 44-39 | Lost 2 |
| » W: John Smoltz (3-11) L: Bryn Smith (7-6) | Third | 7 out |
| Saturday, July 13 |
| » Lost to Braves (42-40), 10-5 | Atlanta-Fulton County Stadium (0-5) | 44-40 | Lost 3 |
| » W: Charlie Leibrandt (8-7) L: Ken Hill (8-6) | Third | 8 out |
| Sunday, July 14 |
| » Lost to Braves (43-40), 2-1 | Atlanta-Fulton County Stadium (0-6) | 44-41 | Lost 4 |
| » W: Tom Glavine (13-4) L: Bob Tewksbury (6-6) | Third | 9 out |
| Monday, July 15 |
| » Defeated Reds (44-41), 5-2 | Riverfront Stadium (2-2) | 45-41 | |
| » W: Omar Olivares (3-1) L: Gino Minutelli (0-1) S: Lee Smith (24) | Third | 9 out |
| Former Cardinal Johnny Vergez dies in Davis, CA at the age of 86. |
| Tuesday, July 16 |
| » Defeated Reds (44-42), 8-7 | Riverfront Stadium (3-2) | 46-41 | Won 2 |
| » W: Willie Fraser (2-2) L: Rob Dibble (0-1) S: Lee Smith (25) | Third | 9 out |
| Wednesday, July 17 |
| » Defeated Reds (44-43), 6-5 | Riverfront Stadium (4-2) | 47-41 | Won 3 |
| » W: Bryn Smith (8-6) L: Jack Armstrong (6-9) S: Lee Smith (26) | Third | 8 out |
| Friday, July 19 |
| » Lost to Braves (46-41), 8-3 | Busch Stadium II (23-20) | 47-42 | |
| » W: Charlie Leibrandt (9-7) L: Ken Hill (8-7) S: Juan Berenguer (15) | Third | 9 out |
| Saturday, July 20 |
| » Defeated Braves (46-42), 2-1 | Busch Stadium II (24-20) | 48-42 | |
| » W: Lee Smith (4-2) L: Mike Stanton (3-2) | Third | 8 out |
| Sunday, July 21 |
| » Lost to Braves (47-42), 5-1 | Busch Stadium II (24-21) | 48-43 | |
| » W: Steve Avery (10-5) L: Omar Olivares (3-2) | Third | 9 out |
| Monday, July 22 |
| » Defeated Astros (37-55), 9-1 | Busch Stadium II (25-21) | 49-43 | |
| » W: Jose DeLeon (4-8) L: Ryan Bowen (0-1) | Third | 8 out |
| » Major-league debuts: Ryan Bowen (Astros) |
| Tuesday, July 23 |
| » Defeated Astros (37-56), 5-1 | Busch Stadium II (26-21) | 50-43 | Won 2 |
| » W: Bryn Smith (9-6) L: Jim Deshaies (3-8) | Third | 8 out |
| Wednesday, July 24 |
| » Defeated Astros (37-57), 4-3 | Busch Stadium II (27-21) | 51-43 | Won 3 |
| » W: Lee Smith (5-2) L: Al Osuna (5-3) | Third | 8 out |
| Friday, July 26 |
| » Defeated Reds (46-48), 5-1 | Busch Stadium II (28-21) | 52-43 | Won 4 |
| » W: Bob Tewksbury (7-6) L: Chris Hammond (7-7) | Third | 8 out |
| Saturday, July 27 |
| » Lost to Reds (47-48), 13-1 | Busch Stadium II (28-22) | 52-44 | |
| » W: Kip Gross (4-1) L: Omar Olivares (3-3) | Third | 9 out |
| Sunday, July 28 |
| » Defeated Reds (47-49), 3-2 | Busch Stadium II (29-22) | 53-44 | |
| » W: Jose DeLeon (5-8) L: Randy Myers (4-8) S: Lee Smith (27) | Third | 8 out |
| Monday, July 29 |
| » Lost to Astros (39-59), 6-2 | Astrodome (2-2) | 53-45 | |
| » W: Jim Deshaies (4-8) L: Bryn Smith (9-7) | Third | 7½ out |
| Tuesday, July 30 |
| » Lost to Astros (40-59), 7-5 | Astrodome (2-3) | 53-46 | Lost 2 |
| » W: Al Osuna (6-3) L: Cris Carpenter (7-3) | Third | 7½ out |
| Wednesday, July 31 |
| » Lost to Astros (41-59), 9-5 | Astrodome (2-4) | 53-47 | Lost 3 |
| » W: Darryl Kile (4-6) L: Bob Tewksbury (7-7) S: Dean Wilkins (1) | Third | 7½ out |
| Thursday, August 1 |
| » Defeated Pirates (60-40), 6-3 | Busch Stadium II (30-22) | 54-47 | |
| » W: Omar Olivares (4-3) L: Randy Tomlin (6-4) S: Lee Smith (28) | Third | 6½ out |
| Friday, August 2 |
| » Defeated Pirates (60-41), 4-3 | Busch Stadium II (31-22) | 55-47 | Won 2 |
| » W: Bob McClure (1-0) L: Stan Belinda (3-3) | Third | 5½ out |
| Saturday, August 3 |
| » Defeated Pirates (60-42), 6-5 | Busch Stadium II (32-22) | 56-47 | Won 3 |
| » W: Lee Smith (6-2) L: Bob Patterson (1-1) | Second | 4½ out |
| Sunday, August 4 |
| » Lost to Pirates (61-42), 2-1 | Busch Stadium II (32-23) | 56-48 | |
| » W: John Smiley (13-7) L: Ken Hill (8-8) | Second | 5½ out |
| Monday, August 5 |
| » Major-league debuts: Anthony Young (Mets) |
| Tuesday, August 6 |
| » Defeated Expos (43-62), 7-6 | Busch Stadium II (33-23) | 57-48 | |
| » W: Scott Terry (3-1) L: Barry Jones (3-8) | Second | 5½ out |
| Wednesday, August 7 |
| » Lost to Expos (44-62), 1-0 | Busch Stadium II (33-24) | 57-49 | |
| » W: Mark Gardner (6-8) L: Omar Olivares (4-4) S: Barry Jones (8) | Second | 5½ out |
| Former Cardinal Jimmy Cooney dies in Warwick, RI at the age of 97. |
| Friday, August 9 |
| » Defeated Pirates (62-45), 5-1 | Three Rivers Stadium (3-1) | 58-49 | |
| » W: Bryn Smith (10-7) L: John Smiley (13-8) | Second | 4 out |
| Saturday, August 10 |
| » Lost to Pirates (63-45), 11-5 | Three Rivers Stadium (3-2) | 58-50 | |
| » W: Neal Heaton (3-1) L: Ken Hill (8-9) | Second | 5 out |
| » Major-league debuts: Hector Fajardo (Pirates) |
| Sunday, August 11 |
| » Lost to Pirates (64-45), 6-4 | Three Rivers Stadium (3-3) | 58-51 | Lost 2 |
| » W: Roger Mason (1-0) L: Bob Tewksbury (7-8) S: Bill Landrum (16) | Second | 6 out |
| Monday, August 12 |
| » Lost to Pirates (65-45), 4-3 | Three Rivers Stadium (3-4) | 58-52 | Lost 3 |
| » W: Bob Patterson (2-1) L: Lee Smith (6-3) | Second | 7 out |
| Tuesday, August 13 |
| » Defeated Mets (57-55), 7-4 | Busch Stadium II (34-24) | 59-52 | |
| » W: Omar Olivares (5-4) L: Frank Viola (12-9) S: Lee Smith (29) | Second | 7 out |
| Wednesday, August 14 |
| » Defeated Mets (57-56), 5-4 | Busch Stadium II (35-24) | 60-52 | Won 2 |
| » W: Cris Carpenter (8-3) L: John Franco (2-7) S: Lee Smith (30) | Second | 7 out |
| Thursday, August 15 |
| » Defeated Mets (57-57), 4-1 | Busch Stadium II (36-24) | 61-52 | Won 3 |
| » W: Rheal Cormier (1-0) L: Wally Whitehurst (5-8) S: Lee Smith (31) | Second | 6 out |
| » Major-league debuts: Rheal Cormier (Cardinals) |
| Friday, August 16 |
| » Defeated Expos (46-68), 4-2 | Stade Olympique (2-2) | 62-52 | Won 4 |
| » W: Bob Tewksbury (8-8) L: Chris Nabholz (2-5) S: Lee Smith (32) | Second | 6 out |
| Saturday, August 17 |
| » Lost to Expos (47-68), 3-0 | Stade Olympique (2-3) | 62-53 | |
| » W: Dennis Martinez (12-7) L: Jose DeLeon (5-9) | Second | 7 out |
| Sunday, August 18 |
| » Defeated Expos (47-69), 4-1 | Stade Olympique (3-3) | 63-53 | |
| » W: Omar Olivares (6-4) L: Mark Gardner (6-9) S: Lee Smith (33) | Second | 7 out |
| Wednesday, August 21 |
| » Defeated Mets (57-61), 7-3 | Shea Stadium (3-1) | 64-53 | Won 2 |
| » W: Bryn Smith (11-7) L: David Cone (10-10) | Second | 6 out |
| » Lost to Mets (58-61), 8-0 | Shea Stadium (3-2) | 64-54 | |
| » W: Sid Fernandez (1-3) L: Rheal Cormier (1-1) | Second | 6 out |
| Thursday, August 22 |
| » Lost to Mets (59-61), 6-0 | Shea Stadium (3-3) | 64-55 | Lost 2 |
| » W: Dwight Gooden (13-7) L: Bob Tewksbury (8-9) S: Tim Burke (6) | Second | 6 out |
| Friday, August 23 |
| » Defeated Dodgers (68-53), 2-1 | Busch Stadium II (37-24) | 65-55 | |
| » W: Cris Carpenter (9-3) L: Tim Crews (2-3) S: Lee Smith (34) | Second | 6 out |
| Saturday, August 24 |
| » Defeated Dodgers (68-54), 7-3 | Busch Stadium II (38-24) | 66-55 | Won 2 |
| » W: Omar Olivares (7-4) L: Mike Morgan (10-8) | Second | 5 out |
| Sunday, August 25 |
| » Defeated Dodgers (68-55), 5-2 | Busch Stadium II (39-24) | 67-55 | Won 3 |
| » W: Rheal Cormier (2-1) L: Tim Belcher (8-8) S: Lee Smith (35) | Second | 5 out |
| Monday, August 26 |
| » Defeated Giants (60-64), 7-6 | Busch Stadium II (40-24) | 68-55 | Won 4 |
| » W: Cris Carpenter (10-3) L: Bud Black (9-13) S: Lee Smith (36) | Second | 4 out |
| Tuesday, August 27 |
| » Defeated Giants (60-65), 5-4 | Busch Stadium II (41-24) | 69-55 | Won 5 |
| » W: Scott Terry (4-1) L: Don Robinson (5-9) S: Lee Smith (37) | Second | 4 out |
| Wednesday, August 28 |
| » Lost to Padres (62-65), 2-1 | Busch Stadium II (41-25) | 69-56 | |
| » W: Bruce Hurst (15-6) L: Scott Terry (4-2) S: Craig Lefferts (19) | Second | 5 out |
| Thursday, August 29 |
| » Lost to Padres (63-65), 1-0 | Busch Stadium II (41-26) | 69-57 | Lost 2 |
| » W: Andy Benes (10-10) L: Omar Olivares (7-5) | Second | 6 out |
| Friday, August 30 |
| » Lost to Giants (61-67), 8-3 | Candlestick Park (3-1) | 69-58 | Lost 3 |
| » W: Bud Black (10-13) L: Rheal Cormier (2-2) S: Jeff Brantley (12) | Second | 7 out |
| Saturday, August 31 |
| » Lost to Giants (62-67), 6-1 | Candlestick Park (3-2) | 69-59 | Lost 4 |
| » W: Bryan Hickerson (1-0) L: Bryn Smith (11-8) | Second | 8 out |
| Sunday, September 1 |
| » Defeated Giants (62-68), 14-1 | Candlestick Park (4-2) | 70-59 | |
| » W: Bob Tewksbury (9-9) L: John Burkett (9-9) | Second | 7 out |
| » Major-league debuts: Gil Heredia (Giants) |
| Monday, September 2 |
| » Defeated Dodgers (72-59), 7-4 | Dodger Stadium (2-2) | 71-59 | Won 2 |
| » W: Willie Fraser (3-2) L: Jay Howell (5-5) | Second | 7 out |
| Tuesday, September 3 |
| » Lost to Dodgers (73-59), 5-4 | Dodger Stadium (2-3) | 71-60 | |
| » W: Jay Howell (6-5) L: Scott Terry (4-3) | Second | 8 out |
| Wednesday, September 4 |
| » Lost to Dodgers (74-59), 8-3 | Dodger Stadium (2-4) | 71-61 | Lost 2 |
| » W: Roger McDowell (6-8) L: Bob McClure (1-1) | Second | 9 out |
| Thursday, September 5 |
| » Lost to Padres (67-68), 3-1 | San Diego/Jack Murphy Stadium (2-2) | 71-62 | Lost 3 |
| » W: Greg Harris (5-4) L: Scott Terry (4-4) S: Jose Melendez (3) | Second | 9½ out |
| Friday, September 6 |
| » Lost to Padres (68-68), 6-2 | San Diego/Jack Murphy Stadium (2-3) | 71-63 | Lost 4 |
| » W: Ricky Bones (3-3) L: Bob Tewksbury (9-10) | Second | 10 out |
| » Major-league debuts: Mark Clark (Cardinals) |
| Saturday, September 7 |
| » Lost to Padres (69-68), 1-0 | San Diego/Jack Murphy Stadium (2-4) | 71-64 | Lost 5 |
| » W: Mike Maddux (6-2) L: Cris Carpenter (10-4) | Second | 10 out |
| Sunday, September 8 |
| » Major-league debuts: Rey Sanchez (Cubs) |
| Monday, September 9 |
| » Defeated Phillies (65-72), 4-2 | Busch Stadium II (42-26) | 72-64 | |
| » W: Omar Olivares (8-5) L: Andy Ashby (0-3) S: Lee Smith (38) | Second | 9½ out |
| Tuesday, September 10 |
| » Lost to Phillies (66-72), 5-2 | Busch Stadium II (42-27) | 72-65 | |
| » W: Tommy Greene (10-7) L: Rheal Cormier (2-3) S: Mitch Williams (26) | Second | 9½ out |
| Wednesday, September 11 |
| » Lost to Pirates (83-56), 3-1 | Busch Stadium II (42-28) | 72-66 | Lost 2 |
| » W: Zane Smith (14-10) L: Bob Tewksbury (9-11) | Second | 10½ out |
| » Major-league debuts: Stan Royer (Cardinals) |
| Thursday, September 12 |
| » Defeated Pirates (83-57), 1-0 | Busch Stadium II (43-28) | 73-66 | |
| » W: Ken Hill (9-9) L: Doug Drabek (13-13) S: Lee Smith (39) | Second | 9½ out |
| Friday, September 13 |
| » Lost to Mets (69-72), 4-2 | Busch Stadium II (43-29) | 73-67 | |
| » W: Tim Burke (5-7) L: Willie Fraser (3-3) | Second | 10½ out |
| Saturday, September 14 |
| » Defeated Mets (69-73), 2-1 | Busch Stadium II (44-29) | 74-67 | |
| » W: Omar Olivares (9-5) L: David Cone (12-13) S: Lee Smith (40) | Second | 10½ out |
| Sunday, September 15 |
| » Defeated Mets (69-74), 7-2 | Busch Stadium II (45-29) | 75-67 | Won 2 |
| » W: Rheal Cormier (3-3) L: Pete Schourek (3-4) | Second | 9½ out |
| Monday, September 16 |
| » Defeated Phillies (67-77), 3-0 | Veteran's Stadium (5-3) | 76-67 | Won 3 |
| » W: Bob Tewksbury (10-11) L: Jose DeJesus (10-6) S: Lee Smith (41) | Second | 9½ out |
| Tuesday, September 17 |
| » Lost to Phillies (68-77), 4-2 | Veteran's Stadium (5-4) | 76-68 | |
| » W: Cliff Brantley (1-1) L: Ken Hill (9-10) S: Mitch Williams (28) | Second | 10½ out |
| Wednesday, September 18 |
| » Lost to Pirates (88-58), 6-5 | Three Rivers Stadium (3-5) | 76-69 | Lost 2 |
| » W: Roger Mason (3-0) L: Willie Fraser (3-4) | Second | 11½ out |
| Thursday, September 19 |
| » Lost to Pirates (89-58), 5-1 | Three Rivers Stadium (3-6) | 76-70 | Lost 3 |
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