| Monday, April 8 |
| » Defeated Rangers (0-1), 5-4 | Arlington Stadium (1-0) | 1-0 | |
| » W: Mark Knudson (1-0) L: Nolan Ryan (0-1) S: Edwin Nunez (1) | First | -- |
| » Major-league debuts: Tony Scruggs (Rangers) |
| Wednesday, April 10 |
| » Defeated Rangers (0-2), 6-0 | Arlington Stadium (2-0) | 2-0 | Won 2 |
| » W: Chris Bosio (1-0) L: Kevin Brown (0-1) | First | -- |
| Thursday, April 11 |
| » Lost to Blue Jays (3-1), 7-3 | Skydome (0-1) | 2-1 | |
| » W: David Wells (1-0) L: Ron Robinson (0-1) | Second | ½ out |
| Friday, April 12 |
| » Lost to Blue Jays (4-1), 5-4 | Skydome (0-2) | 2-2 | Lost 2 |
| » W: Mike Timlin (2-0) L: Dan Plesac (0-1) | Second | 1½ out |
| » Major-league debuts: Denis Boucher (Blue Jays) |
| Saturday, April 13 |
| » Defeated Blue Jays (4-2), 7-3 | Skydome (1-2) | 3-2 | |
| » W: Kevin Brown (1-0) L: Dave Stieb (0-2) S: Chuck Crim (1) | Second | ½ out |
| Sunday, April 14 |
| » Lost to Blue Jays (5-2), 9-0 | Skydome (1-3) | 3-3 | |
| » W: Jimmy Key (2-0) L: Don August (0-1) | Second | 1½ out |
| Monday, April 15 |
| » Lost to Orioles (3-3), 7-2 | County Stadium (0-1) | 3-4 | Lost 2 |
| » W: Jose Mesa (1-1) L: Chris Bosio (1-1) S: Mark Williamson (1) | Fourth | 2½ out |
| Wednesday, April 17 |
| » Defeated Orioles (3-4), 7-3 | County Stadium (1-1) | 4-4 | |
| » W: Jaime Navarro (1-0) L: Dave Johnson (1-1) S: Mark Lee (1) | Second | 1 out |
| Thursday, April 18 |
| » Defeated Orioles (3-5), 4-3 | County Stadium (2-1) | 5-4 | Won 2 |
| » W: Edwin Nunez (1-0) L: Jose Bautista (0-1) | Second | ½ out |
| Friday, April 19 |
| » Lost to Blue Jays (7-4), 5-2 | County Stadium (2-2) | 5-5 | |
| » W: Dave Stieb (1-2) L: Don August (0-2) | Third | 1½ out |
| Saturday, April 20 |
| » Lost to Blue Jays (8-4), 4-2 | County Stadium (2-3) | 5-6 | Lost 2 |
| » W: Jimmy Key (3-0) L: Chris Bosio (1-2) S: Duane Ward (2) | Fourth | 2½ out |
| Sunday, April 21 |
| » Defeated Blue Jays (8-5), 11-8 | County Stadium (3-3) | 6-6 | |
| » W: Chuck Crim (1-0) L: Frank Wills (0-1) | Third | 1½ out |
| Monday, April 22 |
| » Major-league debuts: Mike Magnante (Royals) |
| Tuesday, April 23 |
| » Lost to Rangers (5-5), 6-5 | County Stadium (3-4) | 6-7 | |
| » W: Rich Gossage (1-0) L: Chuck Crim (1-1) S: Jeff Russell (3) | Fourth | 2 out |
| Wednesday, April 24 |
| » Lost to Rangers (6-5), 8-2 | County Stadium (3-5) | 6-8 | Lost 2 |
| » W: Kevin Brown (2-1) L: Mark Knudson (1-1) | Fourth | 2 out |
| Thursday, April 25 |
| » Defeated Rangers (6-6), 9-1 | County Stadium (4-5) | 7-8 | |
| » W: Chris Bosio (2-2) L: Kenny Rogers (0-3) | Fourth | 2 out |
| Friday, April 26 |
| » Defeated Orioles (5-9), 5-4 | Memorial Stadium (1-0) | 8-8 | Won 2 |
| » W: Darren Holmes (1-0) L: Jose Mesa (1-3) S: Edwin Nunez (2) | Third | 2 out |
| Saturday, April 27 |
| » Defeated Orioles (5-10), 5-2 | Memorial Stadium (2-0) | 9-8 | Won 3 |
| » W: Don August (1-2) L: Jeff Robinson (1-2) | Third | 1 out |
| Sunday, April 28 |
| » Lost to Orioles (6-10), 5-4 | Memorial Stadium (2-1) | 9-9 | |
| » W: Bob Milacki (1-0) L: Darren Holmes (1-1) S: Gregg Olson (2) | Third | 2 out |
| Tuesday, April 30 |
| » Defeated White Sox (11-6), 8-2 | County Stadium (5-5) | 10-9 | |
| » W: Chris Bosio (3-2) L: Alex Fernandez (2-2) S: Chuck Crim (2) | Third | 1½ out |
| Wednesday, May 1 |
| » Defeated White Sox (11-7), 10-9 | County Stadium (6-5) | 11-9 | Won 2 |
| » W: Don August (2-2) L: Wayne Edwards (0-1) | Second | ½ out |
| Thursday, May 2 |
| » Defeated Twins (10-12), 5-1 | County Stadium (7-5) | 12-9 | Won 3 |
| » W: Kevin Brown (2-0) L: Kevin Tapani (2-1) S: Chuck Crim (3) | Second | 1 out |
| Friday, May 3 |
| » Defeated Twins (10-13), 6-5 | County Stadium (8-5) | 13-9 | Won 4 |
| » W: Jaime Navarro (2-0) L: Rick Aguilera (0-2) S: Edwin Nunez (3) | Second | 1 out |
| Saturday, May 4 |
| » Lost to Twins (11-13), 7-4 | County Stadium (8-6) | 13-10 | |
| » W: Mark Guthrie (1-2) L: Chris Bosio (3-3) S: Steve Bedrosian (1) | Second | 1 out |
| Sunday, May 5 |
| » Lost to Twins (12-13), 5-2 | County Stadium (8-7) | 13-11 | Lost 2 |
| » W: Rick Aguilera (1-2) L: Edwin Nunez (1-1) | Fourth | 2 out |
| Tuesday, May 7 |
| » Lost to White Sox (12-10), 2-1 | Comiskey Park II (0-1) | 13-12 | Lost 3 |
| » W: Bobby Thigpen (1-0) L: Mark Lee (0-1) | Fourth | 2 out |
| Wednesday, May 8 |
| » Lost to White Sox (13-10), 2-1 | Comiskey Park II (0-2) | 13-13 | Lost 4 |
| » W: Jack McDowell (5-2) L: Jaime Navarro (2-1) | Fourth | 3 out |
| Friday, May 10 |
| » Lost to Royals (10-17), 2-1 | County Stadium (8-8) | 13-14 | Lost 5 |
| » W: Bret Saberhagen (3-3) L: Chris Bosio (3-4) | Fourth | 4½ out |
| Saturday, May 11 |
| » Lost to Royals (11-17), 4-2 | County Stadium (8-9) | 13-15 | Lost 6 |
| » W: Tom Gordon (2-2) L: Bill Wegman (0-1) S: Jeff Montgomery (7) | Fourth | 5½ out |
| Sunday, May 12 |
| » Lost to Royals (12-17), 6-4 | County Stadium (8-10) | 13-16 | Lost 7 |
| » W: Mike Boddicker (3-3) L: Kevin Brown (2-1) S: Jeff Montgomery (8) | Fourth | 5½ out |
| Tuesday, May 14 |
| » Lost to Twins (17-15), 5-1 | Hubert H. Humphrey Metrodome (0-1) | 13-17 | Lost 8 |
| » W: Jack Morris (3-4) L: Jaime Navarro (2-2) | Fourth | 6 out |
| Wednesday, May 15 |
| » Defeated Twins (17-16), 4-2 | Hubert H. Humphrey Metrodome (1-1) | 14-17 | |
| » W: Chris Bosio (4-4) L: Kevin Tapani (2-3) S: Dan Plesac (1) | Fourth | 6 out |
| Thursday, May 16 |
| » Defeated Twins (17-17), 6-3 | Hubert H. Humphrey Metrodome (2-1) | 15-17 | Won 2 |
| » W: Bill Wegman (1-1) L: Allan Anderson (1-3) S: Darren Holmes (1) | Fourth | 5½ out |
| Friday, May 17 |
| » Defeated Royals (13-20), 7-5 | Royals Stadium (1-0) | 16-17 | Won 3 |
| » W: Chuck Crim (2-1) L: Mark Davis (0-1) S: Julio Machado (1) | Third | 4½ out |
| Saturday, May 18 |
| » Lost to Royals (14-20), 7-4 | Royals Stadium (1-1) | 16-18 | |
| » W: Mark Davis (1-1) L: Mark Lee (0-2) S: Jeff Montgomery (9) | Third | 4½ out |
| Sunday, May 19 |
| » Defeated Royals (14-21), 4-2 | Royals Stadium (2-1) | 17-18 | |
| » W: Jaime Navarro (3-2) L: Mark Gubicza (0-2) S: Julio Machado (2) | Third | 3½ out |
| Monday, May 20 |
| » Lost to Red Sox (21-14), 3-0 | Fenway Park (0-1) | 17-19 | |
| » W: Matt Young (3-1) L: Chris Bosio (4-5) S: Jeff Reardon (13) | Fourth | 4½ out |
| Tuesday, May 21 |
| » Lost to Red Sox (22-14), 10-6 | Fenway Park (0-2) | 17-20 | Lost 2 |
| » W: Joe Hesketh (2-0) L: Jim Hunter (0-1) | Fourth | 5½ out |
| Wednesday, May 22 |
| » Lost to Red Sox (23-14), 4-0 | Fenway Park (0-3) | 17-21 | Lost 3 |
| » W: Danny Darwin (2-1) L: Kevin Brown (2-2) S: Greg Harris (1) | Fourth | 6½ out |
| Thursday, May 23 |
| » Defeated Indians (14-23), 7-3 | County Stadium (9-10) | 18-21 | |
| » W: Don August (3-2) L: Charles Nagy (1-4) S: Darren Holmes (2) | Fourth | 5½ out |
| » Major-league debuts: Matias Carrillo (Brewers) |
| Friday, May 24 |
| » Defeated Indians (14-24), 1-0 | County Stadium (10-10) | 19-21 | Won 2 |
| » W: Jaime Navarro (4-2) L: Rod Nichols (0-3) | Fourth | 5½ out |
| Saturday, May 25 |
| » Lost to Indians (15-24), 5-4 | County Stadium (10-11) | 19-22 | |
| » W: Doug Jones (1-3) L: Julio Machado (0-1) | Fourth | 5½ out |
| Sunday, May 26 |
| » Defeated Indians (15-25), 7-6 | County Stadium (11-11) | 20-22 | |
| » W: Chuck Crim (3-1) L: Doug Jones (1-4) | Fourth | 4½ out |
| Monday, May 27 |
| » Lost to Tigers (23-20), 15-9 | County Stadium (11-12) | 20-23 | |
| » W: Mike Henneman (5-1) L: Chuck Crim (3-2) | Fourth | 4½ out |
| Tuesday, May 28 |
| » Defeated Tigers (23-21), 15-2 | County Stadium (12-12) | 21-23 | |
| » W: Don August (4-2) L: Frank Tanana (2-4) | Fourth | 4½ out |
| Wednesday, May 29 |
| » Defeated Tigers (23-22), 6-2 | County Stadium (13-12) | 22-23 | Won 2 |
| » W: Jaime Navarro (5-2) L: Walt Terrell (2-5) | Fourth | 3½ out |
| Friday, May 31 |
| » Lost to Yankees (20-24), 3-2 | Yankee Stadium (0-1) | 22-24 | |
| » W: Steve Howe (2-0) L: Chuck Crim (3-3) | Fourth | 4 out |
| Saturday, June 1 |
| » Defeated Yankees (20-25), 6-3 | Yankee Stadium (1-1) | 23-24 | |
| » W: Bill Wegman (2-1) L: Chuck Cary (1-6) | Third | 3 out |
| Sunday, June 2 |
| » Lost to Yankees (21-25), 7-4 | Yankee Stadium (1-2) | 23-25 | |
| » W: Wade Taylor (1-0) L: Teddy Higuera (0-1) S: Steve Farr (3) | Third | 3 out |
| » Major-league debuts: Wade Taylor (Yankees) |
| Tuesday, June 4 |
| » Lost to Athletics (31-20), 4-3 | Oakland-Alameda County Stadium (0-1) | 23-26 | Lost 2 |
| » W: Bob Welch (5-3) L: Jaime Navarro (5-3) S: Dennis Eckersley (16) | Third | 3½ out |
| Wednesday, June 5 |
| » Lost to Athletics (32-20), 6-4 | Oakland-Alameda County Stadium (0-2) | 23-27 | Lost 3 |
| » W: Dave Stewart (4-2) L: Chris Bosio (4-6) S: Steve Chitren (1) | Fourth | 4½ out |
| Thursday, June 6 |
| » Lost to Athletics (33-20), 9-8 | Oakland-Alameda County Stadium (0-3) | 23-28 | Lost 4 |
| » W: Bruce Walton (1-0) L: Chuck Crim (3-4) S: Dennis Eckersley (17) | Fourth | 4½ out |
| Friday, June 7 |
| » Lost to Mariners (28-25), 2-1 | Kingdome (0-1) | 23-29 | Lost 5 |
| » W: Bill Krueger (2-2) L: Teddy Higuera (0-2) S: Mike Jackson (7) | Fifth | 4½ out |
| Saturday, June 8 |
| » Lost to Mariners (29-25), 6-2 | Kingdome (0-2) | 23-30 | Lost 6 |
| » W: Rich DeLucia (6-3) L: Bill Wegman (2-2) S: Dave Burba (1) | Fifth | 5½ out |
| Sunday, June 9 |
| » Lost to Mariners (30-25), 6-1 | Kingdome (0-3) | 23-31 | Lost 7 |
| » W: Brian Holman (7-5) L: Jaime Navarro (5-4) | Fifth | 6½ out |
| Monday, June 10 |
| » Defeated Angels (32-24), 7-2 | Anaheim Stadium (1-0) | 24-31 | |
| » W: Chris Bosio (5-6) L: Kirk McCaskill (6-6) | Fifth | 6 out |
| Tuesday, June 11 |
| » Lost to Angels (33-24), 4-3 | Anaheim Stadium (1-1) | 24-32 | |
| » W: Mark Langston (8-2) L: Kevin Brown (2-3) S: Bryan Harvey (15) | Fifth | 6 out |
| Wednesday, June 12 |
| » Defeated Angels (33-25), 8-0 | Anaheim Stadium (2-1) | 25-32 | |
| » W: Teddy Higuera (1-2) L: Fernando Valenzuela (0-2) | Fifth | 6 out |
| Saturday, June 15 |
| » Defeated Athletics (36-24), 6-4 | County Stadium (14-12) | 26-32 | Won 2 |
| » W: Jaime Navarro (6-4) L: Dave Stewart (4-3) S: Dan Plesac (2) | Fourth | 6½ out |
| » Lost to Athletics (37-24), 7-3 | County Stadium (14-13) | 26-33 | |
| » W: Andy Hawkins (2-4) L: Kevin Brown (2-4) S: Steve Chitren (2) | Fourth | 6½ out |
| Sunday, June 16 |
| » Defeated Athletics (37-25), 11-7 | County Stadium (15-13) | 27-33 | |
| » W: Chuck Crim (4-4) L: Gene Nelson (0-1) | Fourth | 6 out |
| Monday, June 17 |
| » Defeated Athletics (37-26), 5-0 | County Stadium (16-13) | 28-33 | Won 2 |
| » W: Don August (5-2) L: Mike Moore (8-5) | Fourth | 5 out |
| Tuesday, June 18 |
| » Defeated Angels (34-29), 10-6 | County Stadium (17-13) | 29-33 | Won 3 |
| » W: Teddy Higuera (2-2) L: Joe Grahe (0-1) S: Dan Plesac (3) | Fourth | 4 out |
| Wednesday, June 19 |
| » Lost to Angels (35-29), 4-1 | County Stadium (17-14) | 29-34 | |
| » W: Jim Abbott (6-5) L: Bill Wegman (2-3) S: Bryan Harvey (17) | Fourth | 4 out |
| Thursday, June 20 |
| » Defeated Mariners (35-30), 4-0 | County Stadium (18-14) | 30-34 | |
| » W: Jaime Navarro (7-4) L: Brian Holman (7-7) | Fourth | 4 out |
| Friday, June 21 |
| » Lost to Mariners (36-30), 5-1 | County Stadium (18-15) | 30-35 | |
| » W: Randy Johnson (5-6) L: Chris Bosio (5-7) | Fourth | 5 out |
| Saturday, June 22 |
| » Lost to Mariners (37-30), 5-0 | County Stadium (18-16) | 30-36 | Lost 2 |
| » W: Erik Hanson (4-2) L: Don August (5-3) | Fourth | 6 out |
| Sunday, June 23 |
| » Defeated Mariners (37-31), 5-2 | County Stadium (19-16) | 31-36 | |
| » W: Teddy Higuera (3-2) L: Bill Krueger (4-3) S: Dan Plesac (4) | Fourth | 6 out |
| Tuesday, June 25 |
| » Defeated Tigers (33-36), 11-3 | Tiger Stadium (1-0) | 32-36 | Won 2 |
| » W: Bill Wegman (3-3) L: Walt Terrell (3-8) | Fourth | 5½ out |
| Wednesday, June 26 |
| » Lost to Tigers (34-36), 8-7 | Tiger Stadium (1-1) | 32-37 | |
| » W: John Cerutti (1-2) L: Julio Machado (0-2) | Fourth | 6½ out |
| Thursday, June 27 |
| » Defeated Tigers (34-37), 9-3 | Tiger Stadium (2-1) | 33-37 | |
| » W: Chris Bosio (6-7) L: Bill Gullickson (9-4) | Fourth | 6½ out |
| Friday, June 28 |
| » Defeated Yankees (31-38), 5-2 | County Stadium (20-16) | 34-37 | Won 2 |
| » W: Don August (6-3) L: Scott Kamieniecki (2-1) S: Dan Plesac (5) | Fourth | 5½ out |
| Saturday, June 29 |
| » Lost to Yankees (32-38), 9-8 | County Stadium (20-17) | 34-38 | |
| » W: Lee Guetterman (2-1) L: Dan Plesac (0-2) S: Steve Farr (9) | Fourth | 6½ out |
| Sunday, June 30 |
| » Lost to Yankees (33-38), 8-6 | County Stadium (20-18) | 34-39 | Lost 2 |
| » W: Greg Cadaret (2-3) L: Mark Lee (0-3) S: Steve Farr (10) | Fourth | 7½ out |
| Monday, July 1 |
| » Lost to Red Sox (38-36), 6-0 | County Stadium (20-19) | 34-40 | Lost 3 |
| » W: Roger Clemens (10-5) L: Jaime Navarro (7-5) | Fifth | 8½ out |
| Tuesday, July 2 |
| » Lost to Red Sox (39-36), 14-4 | County Stadium (20-20) | 34-41 | Lost 4 |
| » W: Dennis Lamp (3-1) L: Mark Knudson (1-2) | Fifth | 9½ out |
| Wednesday, July 3 |
| » Lost to Red Sox (40-36), 5-3 | County Stadium (20-21) | 34-42 | Lost 5 |
| » W: Greg Harris (5-7) L: Don August (6-4) S: Jeff Reardon (20) | Fifth | 10½ out |
| Thursday, July 4 |
| » Lost to Indians (25-51), 3-0 | Cleveland Stadium (0-1) | 34-43 | Lost 6 |
| » W: Charles Nagy (4-9) L: Jim Hunter (0-2) | Fifth | 10½ out |
| » Major-league debuts: Jim Austin (Brewers) |
| Friday, July 5 |
| » Defeated Indians (25-52), 4-2 | Cleveland Stadium (1-1) | 35-43 | |
| » W: Bill Wegman (4-3) L: Rod Nichols (0-7) S: Dan Plesac (6) | Fifth | 10½ out |
| Saturday, July 6 |
| » Lost to Indians (26-52), 2-0 | Cleveland Stadium (1-2) | 35-44 | |
| » W: Greg Swindell (5-7) L: Jaime Navarro (7-6) S: Shawn Hillegas (5) | Fifth | 11½ out |
| Sunday, July 7 |
| » Defeated Indians (26-53), 10-6 | Cleveland Stadium (2-2) | 36-44 | |
| » W: Chuck Crim (5-4) L: Jeff Shaw (0-2) S: Dan Plesac (7) | Fifth | 11½ out |
| Thursday, July 11 |
| » Defeated White Sox (43-38), 5-1 | County Stadium (21-21) | 37-44 | Won 2 |
| » W: Bill Wegman (5-3) L: Charlie Hough (5-4) | Fifth | 11½ out |
| Friday, July 12 |
| » Lost to White Sox (44-38), 8-6 | County Stadium (21-22) | 37-45 | |
| » W: Melido Perez (5-4) L: Dan Plesac (0-3) S: Bobby Thigpen (19) | Fifth | 12½ out |
| Saturday, July 13 |
| » Defeated White Sox (44-39), 8-2 | County Stadium (22-22) | 38-45 | |
| » W: Don August (7-4) L: Greg Hibbard (6-8) | Fifth | 12½ out |
| Sunday, July 14 |
| » Lost to White Sox (45-39), 15-1 | County Stadium (22-23) | 38-46 | |
| » W: Jack McDowell (11-4) L: Mark Knudson (1-3) | Fifth | 12½ out |
| Monday, July 15 |
| » Lost to Twins (51-37), 11-7 | County Stadium (22-24) | 38-47 | Lost 2 |
| » W: Mark Guthrie (6-5) L: Jim Hunter (0-3) S: Steve Bedrosian (4) | Fifth | 13½ out |
| » Major-league debuts: Doug Henry (Brewers) |
| Tuesday, July 16 |
| » Defeated Twins (51-38), 4-3 | County Stadium (23-24) | 39-47 | |
| » W: Doug Henry (1-0) L: Rick Aguilera (2-4) | Fifth | 12½ out |
| Wednesday, July 17 |
| » Defeated Mariners (45-44), 6-1 | County Stadium (24-24) | 40-47 | Won 2 |
| » W: Bill Wegman (6-3) L: Randy Johnson (7-7) | Fifth | 12 out |
| Thursday, July 18 |
| » Lost to Mariners (46-44), 12-0 | County Stadium (24-25) | 40-48 | |
| » W: Erik Hanson (5-4) L: Jaime Navarro (7-7) | Fifth | 13 out |
| Friday, July 19 |
| » Lost to White Sox (47-41), 14-3 | Comiskey Park II (0-3) | 40-49 | Lost 2 |
| » W: Jack McDowell (12-4) L: Don August (7-5) | Fifth | 14 out |
| Saturday, July 20 |
| » Lost to White Sox (48-41), 7-6 | Comiskey Park II (0-4) | 40-50 | Lost 3 |
| » W: Bobby Thigpen (6-3) L: Dan Plesac (0-4) | Fifth | 14 out |
| Sunday, July 21 |
| » Defeated White Sox (48-42), 2-1 | Comiskey Park II (1-4) | 41-50 | |
| » W: Chris Bosio (7-7) L: Charlie Hough (5-6) | Fifth | 13 out |
| Monday, July 22 |
| » Lost to White Sox (49-42), 5-4 | Comiskey Park II (1-5) | 41-51 | |
| » W: Greg Hibbard (7-8) L: Bill Wegman (6-4) S: Bobby Thigpen (20) | Fifth | 13½ out |
| Tuesday, July 23 |
| » Lost to Royals (44-48), 8-7 | Royals Stadium (2-2) | 41-52 | Lost 2 |
| » W: Mark Gubicza (5-5) L: Jaime Navarro (7-8) S: Jeff Montgomery (16) | Fifth | 13½ out |
| Wednesday, July 24 |
| » Lost to Royals (45-48), 7-4 | Royals Stadium (2-3) | 41-53 | Lost 3 |
| » W: Storm Davis (3-7) L: Chuck Crim (5-5) S: Jeff Montgomery (17) | Fifth | 14½ out |
| Thursday, July 25 |
| » Lost to Royals (46-48), 2-0 | Royals Stadium (2-4) | 41-54 | Lost 4 |
| » W: Luis Aquino (4-2) L: Jim Hunter (0-4) S: Jeff Montgomery (18) | Fifth | 14½ out |
| Friday, July 26 |
| » Lost to Twins (57-40), 6-3 | Hubert H. Humphrey Metrodome (2-2) | 41-55 | Lost 5 |
| » W: Kevin Tapani (7-7) L: Darren Holmes (1-2) S: Rick Aguilera (26) | Fifth | 15½ out |
| Saturday, July 27 |
| » Lost to Twins (58-40), 7-4 | Hubert H. Humphrey Metrodome (2-3) | 41-56 | Lost 6 |
| » W: Carl Willis (5-2) L: Bill Wegman (6-5) | Fifth | 15½ out |
| » Major-league debuts: Denny Neagle (Twins) |
| Sunday, July 28 |
| » Defeated Twins (58-41), 11-2 | Hubert H. Humphrey Metrodome (3-3) | 42-56 | |
| » W: Jaime Navarro (8-8) L: Jack Morris (13-7) | Fifth | 14½ out |
| Tuesday, July 30 |
| » Defeated Royals (48-50), 9-3 | County Stadium (25-25) | 43-56 | Won 2 |
| » W: Don August (8-5) L: Bret Saberhagen (7-5) S: Dan Plesac (8) | Fifth | 13 out |
| Wednesday, July 31 |
| » Lost to Royals (49-50), 5-4 | County Stadium (25-26) | 43-57 | |
| » W: Luis Aquino (5-2) L: Chris Bosio (7-8) S: Jeff Montgomery (20) | Fifth | 14 out |
| Thursday, August 1 |
| » Lost to Royals (50-50), 6-5 | County Stadium (25-27) | 43-58 | Lost 2 |
| » W: Tom Gordon (7-9) L: Darren Holmes (1-3) S: Jeff Montgomery (21) | Fifth | 15 out |
| Former Brewer Chris Short dies in Wilmington, DE at the age of 54. |
| Friday, August 2 |
| » Lost to Rangers (53-46), 15-1 | County Stadium (25-28) | 43-59 | Lost 3 |
| » W: Brian Bohanon (1-0) L: Jaime Navarro (8-9) | Fifth | 15 out |
| Saturday, August 3 |
| » Lost to Rangers (54-46), 14-5 | County Stadium (25-29) | 43-60 | Lost 4 |
| » W: Jose Guzman (7-4) L: Bill Wegman (6-6) | Fifth | 15 out |
| Sunday, August 4 |
| » Defeated Rangers (54-47), 3-2 | County Stadium (26-29) | 44-60 | |
| » W: Chuck Crim (6-5) L: Jeff Russell (3-4) | Fifth | 15 out |
| Monday, August 5 |
| » Defeated Orioles (42-62), 6-5 | Memorial Stadium (3-1) | 45-60 | Won 2 |
| » W: Doug Henry (2-0) L: Mark Williamson (3-5) S: Edwin Nunez (4) | Fifth | 14½ out |
| Tuesday, August 6 |
| » Lost to Orioles (43-62), 13-5 | Memorial Stadium (3-2) | 45-61 | |
| » W: Dave Johnson (2-3) L: Jim Hunter (0-5) | Fifth | 15½ out |
| Wednesday, August 7 |
| » Defeated Orioles (43-63), 4-2 | Memorial Stadium (4-2) | 46-61 | |
| » W: Jaime Navarro (9-9) L: Ben McDonald (5-6) | Fifth | 15½ out |
| Thursday, August 8 |
| » Defeated Orioles (43-64), 6-4 | Memorial Stadium (5-2) | 47-61 | Won 2 |
| » W: Bill Wegman (7-6) L: Bob Milacki (7-6) S: Edwin Nunez (5) | Fifth | 14½ out |
| Friday, August 9 |
| » Defeated Rangers (56-49), 10-8 | Arlington Stadium (3-0) | 48-61 | Won 3 |
| » W: Chris Bosio (8-8) L: Gerald Alexander (5-2) S: Edwin Nunez (6) | Fifth | 13½ out |
| » Major-league debuts: Jose Hernandez (Rangers) |
| Saturday, August 10 |
| » Defeated Rangers (56-50), 5-2 | Arlington Stadium (4-0) | 49-61 | Won 4 |
| » W: Dan Plesac (1-4) L: Oil Can Boyd (6-11) S: Doug Henry (1) | Fifth | 12½ out |
| Sunday, August 11 |
| » Lost to Rangers (57-50), 5-4 | Arlington Stadium (4-1) | 49-62 | |
| » W: Kenny Rogers (8-7) L: Julio Machado (0-3) | Fifth | 12½ out |
| Monday, August 12 |
| » Defeated Rangers (57-51), 14-7 | Arlington Stadium (5-1) | 50-62 | |
| » W: Jaime Navarro (10-9) L: Bobby Witt (3-5) S: Doug Henry (2) | Fifth | 11½ out |
| Tuesday, August 13 |
| » Defeated Blue Jays (62-52), 5-4 | County Stadium (27-29) | 51-62 | Won 2 |
| » W: Chuck Crim (7-5) L: Tom Henke (0-2) | Fourth | 10½ out |
| Wednesday, August 14 |
| » Defeated Blue Jays (62-53), 5-3 | County Stadium (28-29) | 52-62 | Won 3 |
| » W: Chris Bosio (9-8) L: David Wells (12-8) S: Doug Henry (3) | Fourth | 9½ out |
| Thursday, August 15 |
| » Lost to Blue Jays (63-53), 4-1 | County Stadium (28-30) | 52-63 | |
| » W: Todd Stottlemyre (11-5) L: Dan Plesac (1-5) S: Tom Henke (26) | Fourth | 10½ out |
| Friday, August 16 |
| » Defeated Orioles (48-68), 8-5 | County Stadium (29-30) | 53-63 | |
| » W: Don August (9-5) L: Roy Smith (5-4) | Fourth | 9½ out |
| Saturday, August 17 |
| » Defeated Orioles (48-69), 7-6 | County Stadium (30-30) | 54-63 | Won 2 |
| » W: Jaime Navarro (11-9) L: Ben McDonald (5-7) S: Edwin Nunez (7) | Fourth | 9½ out |
| Sunday, August 18 |
| » Defeated Orioles (48-70), 2-1 | County Stadium (31-30) | 55-63 | Won 3 |
| » W: Bill Wegman (8-6) L: Bob Milacki (7-7) S: Doug Henry (4) | Fourth | 9½ out |
| Tuesday, August 20 |
| » Lost to Blue Jays (66-54), 3-1 | Skydome (1-4) | 55-64 | |
| » W: Todd Stottlemyre (12-5) L: Chris Bosio (9-9) S: Tom Henke (29) | Fifth | 10½ out |
| Wednesday, August 21 |
| » Defeated Blue Jays (66-55), 3-0 | Skydome (2-4) | 56-64 | |
| » W: Julio Machado (1-3) L: Jimmy Key (12-9) S: Edwin Nunez (8) | Fourth | 9½ out |
| Thursday, August 22 |
| » Defeated Blue Jays (66-56), 8-7 | Skydome (3-4) | 57-64 | Won 2 |
| » W: Mike Ignasiak (1-0) L: Duane Ward (5-5) S: Doug Henry (5) | Fourth | 8½ out |
| » Major-league debuts: Mike Ignasiak (Brewers) |
| Friday, August 23 |
| » Defeated Athletics (68-56), 13-4 | Oakland-Alameda County Stadium (1-3) | 58-64 | Won 3 |
| » W: Jaime Navarro (12-9) L: Dave Stewart (9-8) | Fourth | 8½ out |
| Saturday, August 24 |
| » Defeated Athletics (68-57), 7-0 | Oakland-Alameda County Stadium (2-3) | 59-64 | Won 4 |
| » W: Bill Wegman (9-6) L: Joe Slusarski (3-6) | Third | 7½ out |
| Sunday, August 25 |
| » Defeated Athletics (68-58), 8-2 | Oakland-Alameda County Stadium (3-3) | 60-64 | Won 5 |
| » W: Chris Bosio (10-9) L: Ron Darling (8-9) | Third | 7½ out |
| » Major-league debuts: Ron Witmeyer (Athletics) |
| Monday, August 26 |
| » Lost to Mariners (65-61), 5-4 | Kingdome (0-4) | 60-65 | |
| » W: Mike Schooler (1-2) L: Doug Henry (2-1) | Third | 8½ out |
| Tuesday, August 27 |
| » Lost to Mariners (66-61), 6-4 | Kingdome (0-5) | 60-66 | Lost 2 |
| » W: Rich DeLucia (11-8) L: Don August (9-6) S: Mike Jackson (14) | Fourth | 9½ out |
| Wednesday, August 28 |
| » Lost to Mariners (67-61), 7-6 | Kingdome (0-6) | 60-67 | Lost 3 |
| » W: Brian Holman (11-13) L: Jaime Navarro (12-10) S: Bill Swift (11) | Fourth | 10½ out |
| Friday, August 30 |
| » Defeated Angels (63-65), 6-2 | County Stadium (32-30) | 61-67 | |
| » W: Bill Wegman (10-6) L: Kirk McCaskill (10-17) | Fourth | 10 out |
| Saturday, August 31 |
| » Defeated Angels (63-66), 8-2 | County Stadium (33-30) | 62-67 | Won 2 |
| » W: Mark Lee (1-3) L: Joe Grahe (1-7) | Fourth | 10 out |
| Sunday, September 1 |
| » Defeated Angels (63-67), 3-1 | County Stadium (34-30) | 63-67 | Won 3 |
| » W: Jaime Navarro (13-10) L: Chuck Finley (16-8) | Fourth | 9 out |
| Monday, September 2 |
| » Lost to Angels (64-67), 7-6 | County Stadium (34-31) | 63-68 | |
| » W: Jim Abbott (15-8) L: Don August (9-7) S: Bryan Harvey (34) | Fourth | 10 out |
| Tuesday, September 3 |
| » Defeated Athletics (71-62), 5-3 | County Stadium (35-31) | 64-68 | |
| » W: Edwin Nunez (2-1) L: Dennis Eckersley (3-3) | Fourth | 9 out |
| Wednesday, September 4 |
| » Defeated Athletics (71-63), 2-0 | County Stadium (36-31) | 65-68 | Won 2 |
| » W: Bill Wegman (11-6) L: Ron Darling (8-10) S: Doug Henry (6) | Fourth | 9 out |
| Thursday, September 5 |
| » Major-league debuts: Vince Horsman and Randy Knorr (Blue Jays) |
| Friday, September 6 |
| » Lost to Angels (66-68), 2-1 | Anaheim Stadium (2-2) | 65-69 | |
| » W: Joe Grahe (2-7) L: Chris Bosio (10-10) | Fourth | 10½ out |
| Saturday, September 7 |
| » Lost to Angels (67-68), 1-0 | Anaheim Stadium (2-3) | 65-70 | Lost 2 |
| » W: Chuck Finley (17-8) L: Jaime Navarro (13-11) S: Bryan Harvey (36) | Fourth | 11½ out |
| Sunday, September 8 |
| » Lost to Angels (68-68), 1-0 | Anaheim Stadium (2-4) | 65-71 | Lost 3 |
| » W: Jim Abbott (16-8) L: Dan Plesac (1-6) S: Bryan Harvey (37) | Fourth | 12½ out |
| Tuesday, September 10 |
| » Lost to Indians (45-93), 5-2 | County Stadium (36-32) | 65-72 | Lost 4 |
| » W: Doug Jones (2-7) L: Bill Wegman (11-7) S: Steve Olin (10) | Fourth | 12½ out |
| Thursday, September 12 |
| » Defeated Tigers (73-67), 7-0 | County Stadium (37-32) | 66-72 | |
| » W: Chris Bosio (11-10) L: Mark Leiter (8-4) | Fourth | 11½ out |
| Friday, September 13 |
| » Lost to Tigers (74-67), 3-2 | County Stadium (37-33) | 66-73 | |
| » W: Bill Gullickson (18-8) L: Mark Lee (1-4) S: Jeff Kaiser (2) | Fourth | 12½ out |
| Saturday, September 14 |
| » Lost to Tigers (75-67), 6-4 | County Stadium (37-34) | 66-74 | Lost 2 |
| » W: Scott Aldred (1-3) L: Dan Plesac (1-7) | Fourth | 13½ out |
| Sunday, September 15 |
| » Defeated Tigers (75-68), 5-3 | County Stadium (38-34) | 67-74 | |
| » W: Bill Wegman (12-7) L: Frank Tanana (11-11) S: Doug Henry (7) | Fourth | 12½ out |
| Monday, September 16 |
| » Defeated Yankees (61-82), 5-4 | Yankee Stadium (2-2) | 68-74 | Won 2 |
| » W: Mark Lee (2-4) L: Wade Taylor (7-10) S: Doug Henry (8) | Fourth | 11½ out |
| Tuesday, September 17 |
| » Defeated Yankees (61-83), 2-0 | Yankee Stadium (3-2) | 69-74 | Won 3 |
| » W: Chris Bosio (12-10) L: Pascual Perez (1-4) | Fourth | 10½ out |
| Wednesday, September 18 |
| » Lost to Yankees (62-83), 2-1 | Yankee Stadium (3-3) | 69-75 | |
| » W: Steve Farr (4-4) L: Jaime Navarro (13-12) | Fourth | 11½ out |
| » Major-league debuts: John Ramos (Yankees) |
| Friday, September 20 |
| » Defeated Tigers (75-71), 8-5 | Tiger Stadium (3-1) | 70-75 | |
| » W: Dan Plesac (2-7) L: Mark Leiter (8-5) S: Doug Henry (9) | Fourth | 10½ out |
| » Major-league debuts: Jim Olander (Brewers) |
| Saturday, September 21 |
| » Defeated Tigers (75-72), 5-2 | Tiger Stadium (4-1) | 71-75 | Won 2 |
| » W: Bill Wegman (13-7) L: Frank Tanana (11-12) S: Doug Henry (10) | Fourth | 9½ out |
| Sunday, September 22 |
| » Defeated Tigers (75-73), 9-5 | Tiger Stadium (5-1) | 72-75 | Won 3 |
| » W: Chris Bosio (13-10) L: Walt Terrell (12-12) | Fourth | 9½ out |
| Monday, September 23 |
| » Lost to Yankees (64-85), 9-8 | County Stadium (38-35) | 72-76 | |
| » W: Rich Monteleone (2-1) L: Mark Lee (2-5) S: Steve Farr (20) | Fourth | 9½ out |
| Tuesday, September 24 |
| » Defeated Yankees (64-86), 5-4 | County Stadium (39-35) | 73-76 | |
| » W: Cal Eldred (1-0) L: Eric Plunk (2-5) S: Doug Henry (11) | Fourth | 9½ out |
| » Major-league debuts: Cal Eldred (Brewers) |
| Wednesday, September |