| Monday, April 8 |
| » Lost to Reds (1-0), 6-2 | Riverfront Stadium (0-1) | 0-1 | |
| » W: Tom Browning (1-0) L: Mike Scott (0-1) S: Rob Dibble (1) | Third | 1 out |
| » Major-league debuts: Jeff Bagwell and Darryl Kile (Astros) |
| Wednesday, April 10 |
| » Lost to Reds (2-0), 6-5 | Riverfront Stadium (0-2) | 0-2 | Lost 2 |
| » W: Ted Power (1-0) L: Darryl Kile (0-1) S: Randy Myers (1) | Fourth | 2 out |
| Thursday, April 11 |
| » Defeated Reds (2-1), 4-1 | Riverfront Stadium (1-2) | 1-2 | |
| » W: Pete Harnisch (1-0) L: Norm Charlton (0-1) S: Curt Schilling (1) | Third | 1½ out |
| Friday, April 12 |
| » Defeated Giants (1-3), 3-2 | Astrodome (1-0) | 2-2 | Won 2 |
| » W: Mark Portugal (1-0) L: Rick Reuschel (0-1) S: Dwayne Henry (1) | Third | 1 out |
| Saturday, April 13 |
| » Lost to Giants (2-3), 16-2 | Astrodome (1-1) | 2-3 | |
| » W: Scott Garrelts (1-0) L: Mike Scott (0-2) S: Eric Gunderson (1) | Third | 2 out |
| Sunday, April 14 |
| » Defeated Giants (2-4), 7-2 | Astrodome (2-1) | 3-3 | |
| » W: Jimmy Jones (1-0) L: John Burkett (0-1) | Third | 2 out |
| Monday, April 15 |
| » Defeated Braves (2-3), 3-1 | Atlanta-Fulton County Stadium (1-0) | 4-3 | Won 2 |
| » W: Al Osuna (1-0) L: Kent Mercker (0-1) S: Curt Schilling (2) | Second | 2 out |
| Tuesday, April 16 |
| » Lost to Braves (3-3), 10-4 | Atlanta-Fulton County Stadium (1-1) | 4-4 | |
| » W: Doug Sisk (1-0) L: Xavier Hernandez (0-1) | Third | 2 out |
| Wednesday, April 17 |
| » Defeated Braves (3-4), 4-3 | Atlanta-Fulton County Stadium (2-1) | 5-4 | |
| » W: Mark Portugal (2-0) L: Steve Avery (1-1) S: Curt Schilling (3) | Second | 1 out |
| Friday, April 19 |
| » Lost to Giants (4-6), 5-2 | Candlestick Park (0-1) | 5-5 | |
| » W: John Burkett (1-1) L: Jimmy Jones (1-1) S: Jeff Brantley (1) | Third | 1½ out |
| Saturday, April 20 |
| » Lost to Giants (5-6), 4-0 | Candlestick Park (0-2) | 5-6 | Lost 2 |
| » W: Bud Black (1-2) L: Jim Deshaies (0-1) | Third | 2½ out |
| Sunday, April 21 |
| » Lost to Giants (6-6), 1-0 | Candlestick Park (0-3) | 5-7 | Lost 3 |
| » W: Dave Righetti (2-0) L: Curt Schilling (0-1) | Fourth | 2½ out |
| Monday, April 22 |
| » Defeated Reds (6-6), 2-1 | Astrodome (3-1) | 6-7 | |
| » W: Dwayne Henry (1-0) L: Randy Myers (0-1) | Third | 2½ out |
| Tuesday, April 23 |
| » Lost to Reds (7-6), 3-1 | Astrodome (3-2) | 6-8 | |
| » W: Chris Hammond (2-0) L: Jim Corsi (0-1) S: Rob Dibble (2) | Fourth | 3½ out |
| Wednesday, April 24 |
| » Defeated Reds (7-7), 1-0 | Astrodome (4-2) | 7-8 | |
| » W: Dwayne Henry (2-0) L: Scott Scudder (0-1) | Third | 2½ out |
| Friday, April 26 |
| » Lost to Braves (7-7), 7-2 | Astrodome (4-3) | 7-9 | |
| » W: Charlie Leibrandt (2-1) L: Jim Deshaies (0-2) | Fifth | 3½ out |
| Saturday, April 27 |
| » Lost to Braves (8-7), 2-1 | Astrodome (4-4) | 7-10 | Lost 2 |
| » W: Doug Sisk (2-0) L: Jim Corsi (0-2) S: Jeff Parrett (1) | Sixth | 3½ out |
| Sunday, April 28 |
| » Defeated Braves (8-8), 2-0 | Astrodome (5-4) | 8-10 | |
| » W: Jimmy Jones (2-1) L: Tom Glavine (2-2) S: Dwayne Henry (2) | Fifth | 2½ out |
| Tuesday, April 30 |
| » Lost to Cubs (10-11), 10-3 | Wrigley Field (0-1) | 8-11 | |
| » W: Mike Bielecki (4-1) L: Mark Portugal (2-1) | Fifth | 3 out |
| Wednesday, May 1 |
| » Lost to Cubs (11-11), 11-8 | Wrigley Field (0-2) | 8-12 | Lost 2 |
| » W: Greg Maddux (3-1) L: Jim Deshaies (0-3) | Fifth | 3 out |
| Friday, May 3 |
| » Lost to Pirates (15-7), 1-0 | Three Rivers Stadium (0-1) | 8-13 | Lost 3 |
| » W: Zane Smith (3-1) L: Pete Harnisch (1-1) | Fifth | 3 out |
| Saturday, May 4 |
| » Defeated Pirates (15-8), 8-3 | Three Rivers Stadium (1-1) | 9-13 | |
| » W: Jimmy Jones (3-1) L: John Smiley (4-1) S: Jim Clancy (1) | Fifth | 3 out |
| Sunday, May 5 |
| » Defeated Pirates (15-9), 6-4 | Three Rivers Stadium (2-1) | 10-13 | Won 2 |
| » W: Mark Portugal (3-1) L: Doug Drabek (1-5) S: Curt Schilling (4) | Fifth | 3 out |
| Monday, May 6 |
| » Lost to Cubs (13-13), 4-3 | Astrodome (5-5) | 10-14 | |
| » W: Greg Maddux (4-1) L: Jim Deshaies (0-4) S: Dave Smith (6) | Fifth | 3½ out |
| Tuesday, May 7 |
| » Lost to Cubs (14-13), 4-3 | Astrodome (5-6) | 10-15 | Lost 2 |
| » W: Bob Scanlan (1-0) L: Xavier Hernandez (0-2) S: Dave Smith (7) | Fifth | 4½ out |
| » Major-league debuts: Bob Scanlan (Cubs) |
| Wednesday, May 8 |
| » Defeated Cubs (14-14), 4-2 | Astrodome (6-6) | 11-15 | |
| » W: Pete Harnisch (2-1) L: Shawn Boskie (2-3) S: Curt Schilling (5) | Fourth | 3½ out |
| Friday, May 10 |
| » Lost to Cardinals (15-13), 7-5 | Astrodome (6-7) | 11-16 | |
| » W: Juan Agosto (2-0) L: Curt Schilling (0-2) S: Lee Smith (10) | Fifth | 3 out |
| Saturday, May 11 |
| » Defeated Cardinals (15-14), 6-1 | Astrodome (7-7) | 12-16 | |
| » W: Mark Portugal (4-1) L: Jose DeLeon (1-3) | Fifth | 3 out |
| Sunday, May 12 |
| » Lost to Cardinals (16-14), 7-3 | Astrodome (7-8) | 12-17 | |
| » W: Cris Carpenter (4-1) L: Al Osuna (1-1) | Fourth | 4 out |
| Tuesday, May 14 |
| » Lost to Pirates (20-11), 6-3 | Astrodome (7-9) | 12-18 | Lost 2 |
| » W: Zane Smith (5-1) L: Pete Harnisch (2-2) | Fifth | 4½ out |
| Wednesday, May 15 |
| » Lost to Pirates (21-11), 8-7 | Astrodome (7-10) | 12-19 | Lost 3 |
| » W: Bob Kipper (2-1) L: Curt Schilling (0-3) S: Bill Landrum (5) | Fifth | 5½ out |
| Thursday, May 16 |
| » Lost to Pirates (22-11), 6-4 | Astrodome (7-11) | 12-20 | Lost 4 |
| » W: Doug Drabek (2-6) L: Jim Clancy (0-1) S: Stan Belinda (5) | Fifth | 6 out |
| Friday, May 17 |
| » Defeated Cardinals (18-16), 5-4 | Busch Stadium II (1-0) | 13-20 | |
| » W: Jim Deshaies (1-4) L: Lee Smith (2-2) S: Al Osuna (1) | Fifth | 5 out |
| Saturday, May 18 |
| » Lost to Cardinals (19-16), 12-2 | Busch Stadium II (1-1) | 13-21 | |
| » W: Bryn Smith (4-1) L: Xavier Hernandez (0-3) | Fifth | 6 out |
| Sunday, May 19 |
| » Lost to Cardinals (20-16), 9-2 | Busch Stadium II (1-2) | 13-22 | Lost 2 |
| » W: Ken Hill (4-2) L: Pete Harnisch (2-3) | Fifth | 7 out |
| Monday, May 20 |
| » Defeated Dodgers (20-16), 4-1 | Astrodome (8-11) | 14-22 | |
| » W: Jimmy Jones (4-1) L: Kevin Gross (2-4) S: Al Osuna (2) | Fifth | 6 out |
| Former Astro Pete Runnels dies in Pasadena, TX at the age of 64. |
| Tuesday, May 21 |
| » Lost to Dodgers (21-16), 7-3 | Astrodome (8-12) | 14-23 | |
| » W: Bob Ojeda (3-3) L: Jim Corsi (0-3) | Fifth | 7 out |
| Wednesday, May 22 |
| » Defeated Dodgers (21-17), 3-2 | Astrodome (9-12) | 15-23 | |
| » W: Jim Deshaies (2-4) L: Mike Morgan (4-4) S: Al Osuna (3) | Fifth | 6 out |
| Thursday, May 23 |
| » Lost to Dodgers (22-17), 2-0 | Astrodome (9-13) | 15-24 | |
| » W: Tim Belcher (4-4) L: Xavier Hernandez (0-4) S: Jay Howell (8) | Fifth | 7 out |
| Friday, May 24 |
| » Defeated Padres (21-21), 1-0 | Astrodome (10-13) | 16-24 | |
| » W: Curt Schilling (1-3) L: Andy Benes (2-5) | Fifth | 7 out |
| Saturday, May 25 |
| » Lost to Padres (22-21), 4-2 | Astrodome (10-14) | 16-25 | |
| » W: Rich Rodriguez (2-1) L: Al Osuna (1-2) S: Craig Lefferts (10) | Fifth | 8 out |
| » Major-league debuts: Jose Mota (Padres) |
| Sunday, May 26 |
| » Defeated Padres (22-22), 13-3 | Astrodome (11-14) | 17-25 | |
| » W: Mark Portugal (5-1) L: Ed Whitson (3-5) | Fifth | 7 out |
| Monday, May 27 |
| » Lost to Dodgers (25-18), 4-1 | Dodger Stadium (0-1) | 17-26 | |
| » W: Mike Morgan (5-4) L: Jim Deshaies (2-5) S: Jay Howell (9) | Fifth | 8 out |
| Tuesday, May 28 |
| » Lost to Dodgers (26-18), 8-2 | Dodger Stadium (0-2) | 17-27 | Lost 2 |
| » W: Tim Belcher (5-4) L: Xavier Hernandez (0-5) | Fifth | 9 out |
| Wednesday, May 29 |
| » Defeated Dodgers (26-19), 8-2 | Dodger Stadium (1-2) | 18-27 | |
| » W: Pete Harnisch (3-3) L: Orel Hershiser (0-1) S: Al Osuna (4) | Fifth | 8 out |
| Thursday, May 30 |
| » Lost to Padres (23-25), 4-0 | San Diego/Jack Murphy Stadium (0-1) | 18-28 | |
| » W: Dennis Rasmussen (1-0) L: Jimmy Jones (4-2) | Fifth | 8 out |
| Friday, May 31 |
| » Lost to Padres (24-25), 5-4 | San Diego/Jack Murphy Stadium (0-2) | 18-29 | Lost 2 |
| » W: Jose Melendez (1-0) L: Mark Portugal (5-2) S: Craig Lefferts (11) | Fifth | 9 out |
| Saturday, June 1 |
| » Lost to Padres (25-25), 7-2 | San Diego/Jack Murphy Stadium (0-3) | 18-30 | Lost 3 |
| » W: Bruce Hurst (6-2) L: Jim Deshaies (2-6) | Fifth | 9 out |
| Sunday, June 2 |
| » Lost to Padres (26-25), 3-1 | San Diego/Jack Murphy Stadium (0-4) | 18-31 | Lost 4 |
| » W: Adam Peterson (2-1) L: Xavier Hernandez (0-6) S: Craig Lefferts (12) | Fifth | 10 out |
| Tuesday, June 4 |
| » Lost to Expos (21-29), 4-1 | Astrodome (11-15) | 18-32 | Lost 5 |
| » W: Mark Gardner (1-2) L: Pete Harnisch (3-4) S: Barry Jones (3) | Sixth | 10 out |
| Wednesday, June 5 |
| » Lost to Expos (22-29), 8-2 | Astrodome (11-16) | 18-33 | Lost 6 |
| » W: Dennis Martinez (7-4) L: Jimmy Jones (4-3) | Sixth | 11 out |
| Thursday, June 6 |
| » Defeated Expos (22-30), 9-8 | Astrodome (12-16) | 19-33 | |
| » W: Curt Schilling (2-3) L: Barry Jones (2-4) | Sixth | 11 out |
| Friday, June 7 |
| » Lost to Mets (28-23), 6-3 | Astrodome (12-17) | 19-34 | |
| » W: Doug Simons (2-2) L: Curt Schilling (2-4) | Sixth | 12 out |
| Saturday, June 8 |
| » Lost to Mets (29-23), 4-3 | Astrodome (12-18) | 19-35 | Lost 2 |
| » W: Alejandro Pena (2-0) L: Mike Capel (0-1) S: John Franco (12) | Sixth | 12 out |
| Sunday, June 9 |
| » Defeated Mets (29-24), 1-0 | Astrodome (13-18) | 20-35 | |
| » W: Pete Harnisch (4-4) L: David Cone (6-4) | Sixth | 12 out |
| Monday, June 10 |
| » Defeated Mets (29-25), 6-4 | Astrodome (14-18) | 21-35 | Won 2 |
| » W: Curt Schilling (3-4) L: John Franco (1-5) S: Mike Capel (1) | Sixth | 12 out |
| Tuesday, June 11 |
| » Defeated Phillies (25-32), 1-0 | Astrodome (15-18) | 22-35 | Won 3 |
| » W: Al Osuna (2-2) L: Roger McDowell (3-2) | Sixth | 11½ out |
| Wednesday, June 12 |
| » Defeated Phillies (25-33), 3-2 | Astrodome (16-18) | 23-35 | Won 4 |
| » W: Al Osuna (3-2) L: Joe Boever (3-5) | Fifth | 10½ out |
| Thursday, June 13 |
| » Lost to Phillies (26-33), 5-4 | Astrodome (16-19) | 23-36 | |
| » W: Jose DeJesus (3-2) L: Darryl Kile (0-2) S: Mitch Williams (11) | Fifth | 11½ out |
| Friday, June 14 |
| » Defeated Mets (30-28), 4-1 | Shea Stadium (1-0) | 24-36 | |
| » W: Mike Capel (1-1) L: John Franco (1-6) S: Jim Clancy (2) | Fifth | 11½ out |
| Saturday, June 15 |
| » Lost to Mets (31-28), 6-0 | Shea Stadium (1-1) | 24-37 | |
| » W: Dwight Gooden (6-5) L: Jimmy Jones (4-4) | Sixth | 11½ out |
| Sunday, June 16 |
| » Defeated Mets (31-29), 5-4 | Shea Stadium (2-1) | 25-37 | |
| » W: Mark Portugal (6-2) L: Frank Viola (7-4) S: Al Osuna (5) | Fifth | 11½ out |
| Monday, June 17 |
| » Lost to Expos (29-34), 3-2 | Stade Olympique (0-1) | 25-38 | |
| » W: Jeff Fassero (1-1) L: Curt Schilling (3-5) | Fifth | 12½ out |
| Tuesday, June 18 |
| » Lost to Expos (30-34), 3-2 | Stade Olympique (0-2) | 25-39 | Lost 2 |
| » W: Bill Sampen (5-1) L: Jim Corsi (0-4) | Fifth | 13½ out |
| Wednesday, June 19 |
| » Lost to Expos (31-34), 3-1 | Stade Olympique (0-3) | 25-40 | Lost 3 |
| » W: Mark Gardner (3-3) L: Pete Harnisch (4-5) S: Jeff Fassero (2) | Fifth | 14½ out |
| Thursday, June 20 |
| » Lost to Phillies (29-37), 7-3 | Veteran's Stadium (0-1) | 25-41 | Lost 4 |
| » W: Danny Cox (2-1) L: Jimmy Jones (4-5) | Sixth | 15½ out |
| Friday, June 21 |
| » Lost to Phillies (30-37), 3-0 | Veteran's Stadium (0-2) | 25-42 | Lost 5 |
| » W: Bruce Ruffin (1-0) L: Mark Portugal (6-3) S: Mitch Williams (12) | Sixth | 15½ out |
| Saturday, June 22 |
| » Defeated Phillies (30-38), 4-3 | Veteran's Stadium (1-2) | 26-42 | |
| » W: Al Osuna (4-2) L: Roger McDowell (3-4) S: Mike Capel (2) | Sixth | 15½ out |
| Sunday, June 23 |
| » Defeated Phillies (30-39), 6-4 | Veteran's Stadium (2-2) | 27-42 | Won 2 |
| » W: Darryl Kile (1-2) L: Jose DeJesus (4-3) S: Jim Clancy (3) | Sixth | 15½ out |
| Tuesday, June 25 |
| » Defeated Braves (34-33), 1-0 | Astrodome (17-19) | 28-42 | Won 3 |
| » W: Pete Harnisch (5-5) L: Tom Glavine (11-4) | Sixth | 14½ out |
| Wednesday, June 26 |
| » Lost to Braves (35-33), 3-2 | Astrodome (17-20) | 28-43 | |
| » W: Mike Stanton (3-1) L: Jim Clancy (0-2) S: Juan Berenguer (11) | Sixth | 14½ out |
| Thursday, June 27 |
| » Lost to Braves (36-33), 3-0 | Astrodome (17-21) | 28-44 | Lost 2 |
| » W: Charlie Leibrandt (7-5) L: Mark Portugal (6-4) | Sixth | 15 out |
| Friday, June 28 |
| » Lost to Reds (40-32), 8-5 | Riverfront Stadium (1-3) | 28-45 | Lost 3 |
| » W: Tom Browning (10-4) L: Jim Deshaies (2-7) S: Rob Dibble (21) | Sixth | 15½ out |
| Saturday, June 29 |
| » Defeated Reds (40-33), 6-2 | Riverfront Stadium (2-3) | 29-45 | |
| » W: Darryl Kile (2-2) L: Don Carman (0-2) S: Jim Clancy (4) | Sixth | 15½ out |
| Sunday, June 30 |
| » Lost to Reds (41-33), 5-4 | Riverfront Stadium (2-4) | 29-46 | |
| » W: Chris Hammond (6-5) L: Pete Harnisch (5-6) S: Rob Dibble (22) | Sixth | 16½ out |
| Tuesday, July 2 |
| » Defeated Giants (33-43), 8-4 | Candlestick Park (1-3) | 30-46 | |
| » W: Mark Portugal (7-4) L: Bud Black (6-7) | Sixth | 16½ out |
| Wednesday, July 3 |
| » Defeated Giants (33-44), 9-0 | Candlestick Park (2-3) | 31-46 | Won 2 |
| » W: Jim Deshaies (3-7) L: John Burkett (4-5) | Sixth | 16½ out |
| Thursday, July 4 |
| » Defeated Giants (33-45), 14-6 | Candlestick Park (3-3) | 32-46 | Won 3 |
| » W: Darryl Kile (3-2) L: Trevor Wilson (4-7) | Sixth | 15½ out |
| Friday, July 5 |
| » Lost to Reds (44-34), 1-0 | Astrodome (17-22) | 32-47 | |
| » W: Chris Hammond (7-5) L: Pete Harnisch (5-7) S: Rob Dibble (23) | Sixth | 15½ out |
| Saturday, July 6 |
| » Defeated Reds (44-35), 3-0 | Astrodome (18-22) | 33-47 | |
| » W: Jimmy Jones (5-5) L: Jack Armstrong (6-7) | Sixth | 15½ out |
| Sunday, July 7 |
| » Defeated Reds (44-36), 7-3 | Astrodome (19-22) | 34-47 | Won 2 |
| » W: Mark Portugal (8-4) L: Tom Browning (10-5) | Sixth | 15½ out |
| Thursday, July 11 |
| » Defeated Cubs (38-45), 6-4 | Wrigley Field (1-2) | 35-47 | Won 3 |
| » W: Al Osuna (5-2) L: Dave Smith (0-5) S: Mike Capel (3) | Fifth | 14½ out |
| Friday, July 12 |
| » Lost to Cubs (39-45), 5-2 | Wrigley Field (1-3) | 35-48 | |
| » W: Frank Castillo (2-0) L: Mark Portugal (8-5) S: Paul Assenmacher (7) | Fifth | 14½ out |
| » Major-league debuts: Scott Servais (Astros) |
| Saturday, July 13 |
| » Lost to Cubs (40-45), 4-3 | Wrigley Field (1-4) | 35-49 | Lost 2 |
| » W: Les Lancaster (5-3) L: Mike Capel (1-2) | Sixth | 15 out |
| Sunday, July 14 |
| » Lost to Cubs (41-45), 4-3 | Wrigley Field (1-5) | 35-50 | Lost 3 |
| » W: Mike Bielecki (10-6) L: Darryl Kile (3-3) S: Paul Assenmacher (8) | Sixth | 14½ out |
| Monday, July 15 |
| » Lost to Pirates (53-31), 8-0 | Three Rivers Stadium (2-2) | 35-51 | Lost 4 |
| » W: Randy Tomlin (4-3) L: Jimmy Jones (5-6) | Sixth | 14½ out |
| Tuesday, July 16 |
| » Lost to Pirates (54-31), 6-4 | Three Rivers Stadium (2-3) | 35-52 | Lost 5 |
| » W: Zane Smith (10-6) L: Darryl Kile (3-4) S: Stan Belinda (8) | Sixth | 14½ out |
| Wednesday, July 17 |
| » Defeated Pirates (54-32), 10-2 | Three Rivers Stadium (3-3) | 36-52 | |
| » W: Jimmy Jones (6-6) L: Doug Drabek (9-9) S: Al Osuna (6) | Sixth | 13½ out |
| » Major-league debuts: John Wehner (Pirates) |
| Friday, July 19 |
| » Defeated Cubs (42-48), 5-2 | Astrodome (20-22) | 37-52 | Won 2 |
| » W: Pete Harnisch (6-7) L: Bob Scanlan (3-5) S: Al Osuna (7) | Sixth | 13 out |
| Saturday, July 20 |
| » Lost to Cubs (43-48), 6-0 | Astrodome (20-23) | 37-53 | |
| » W: Greg Maddux (8-6) L: Darryl Kile (3-5) | Sixth | 14 out |
| Sunday, July 21 |
| » Lost to Cubs (44-48), 4-2 | Astrodome (20-24) | 37-54 | Lost 2 |
| » W: Frank Castillo (3-0) L: Jim Clancy (0-3) | Sixth | 14 out |
| Monday, July 22 |
| » Lost to Cardinals (49-43), 9-1 | Busch Stadium II (1-3) | 37-55 | Lost 3 |
| » W: Jose DeLeon (4-8) L: Ryan Bowen (0-1) | Sixth | 14½ out |
| » Major-league debuts: Ryan Bowen (Astros) |
| Tuesday, July 23 |
| » Lost to Cardinals (50-43), 5-1 | Busch Stadium II (1-4) | 37-56 | Lost 4 |
| » W: Bryn Smith (9-6) L: Jim Deshaies (3-8) | Sixth | 15½ out |
| Wednesday, July 24 |
| » Lost to Cardinals (51-43), 4-3 | Busch Stadium II (1-5) | 37-57 | Lost 5 |
| » W: Lee Smith (5-2) L: Al Osuna (5-3) | Sixth | 16½ out |
| Friday, July 26 |
| » Lost to Pirates (59-34), 8-1 | Astrodome (20-25) | 37-58 | Lost 6 |
| » W: Neal Heaton (2-1) L: Darryl Kile (3-6) | Sixth | 18 out |
| Saturday, July 27 |
| » Lost to Pirates (60-34), 11-5 | Astrodome (20-26) | 37-59 | Lost 7 |
| » W: Randy Tomlin (6-3) L: Jimmy Jones (6-7) | Sixth | 19 out |
| Sunday, July 28 |
| » Defeated Pirates (60-35), 9-7 | Astrodome (21-26) | 38-59 | |
| » W: Ryan Bowen (1-1) L: Zane Smith (10-8) S: Jim Clancy (5) | Sixth | 18 out |
| » Major-league debuts: Jose Tolentino (Astros) |
| Monday, July 29 |
| » Defeated Cardinals (53-45), 6-2 | Astrodome (22-26) | 39-59 | Won 2 |
| » W: Jim Deshaies (4-8) L: Bryn Smith (9-7) | Sixth | 17 out |
| Tuesday, July 30 |
| » Defeated Cardinals (53-46), 7-5 | Astrodome (23-26) | 40-59 | Won 3 |
| » W: Al Osuna (6-3) L: Cris Carpenter (7-3) | Sixth | 17 out |
| Wednesday, July 31 |
| » Defeated Cardinals (53-47), 9-5 | Astrodome (24-26) | 41-59 | Won 4 |
| » W: Darryl Kile (4-6) L: Bob Tewksbury (7-7) S: Dean Wilkins (1) | Sixth | 17 out |
| Thursday, August 1 |
| » Major-league debuts: Milt Hill (Reds) |
| Friday, August 2 |
| » Defeated Dodgers (58-43), 9-8 | Astrodome (25-26) | 42-59 | Won 5 |
| » W: Dean Wilkins (1-0) L: Jay Howell (4-3) | Sixth | 16 out |
| Saturday, August 3 |
| » Defeated Dodgers (58-44), 2-1 | Astrodome (26-26) | 43-59 | Won 6 |
| » W: Dean Wilkins (2-0) L: Jay Howell (4-4) | Sixth | 15 out |
| Sunday, August 4 |
| » Defeated Dodgers (58-45), 2-1 | Astrodome (27-26) | 44-59 | Won 7 |
| » W: Al Osuna (7-3) L: Kevin Gross (6-7) | Sixth | 14 out |
| Monday, August 5 |
| » Defeated Padres (50-55), 2-1 | Astrodome (28-26) | 45-59 | Won 8 |
| » W: Dwayne Henry (3-0) L: Larry Andersen (3-3) | Sixth | 13 out |
| Tuesday, August 6 |
| » Defeated Padres (50-56), 6-1 | Astrodome (29-26) | 46-59 | Won 9 |
| » W: Darryl Kile (5-6) L: Adam Peterson (3-4) S: Al Osuna (8) | Sixth | 13 out |
| Wednesday, August 7 |
| » Lost to Padres (51-56), 7-4 | Astrodome (29-27) | 46-60 | |
| » W: Bruce Hurst (14-5) L: Dean Wilkins (2-1) S: Larry Andersen (7) | Sixth | 14 out |
| Thursday, August 8 |
| » Lost to Padres (52-56), 5-3 | Astrodome (29-28) | 46-61 | Lost 2 |
| » W: Andy Benes (7-10) L: Ryan Bowen (1-2) S: Craig Lefferts (17) | Sixth | 15 out |
| » Major-league debuts: Tony Eusebio (Astros) |
| Friday, August 9 |
| » Lost to Braves (57-50), 7-2 | Atlanta-Fulton County Stadium (2-2) | 46-62 | Lost 3 |
| » W: Steve Avery (13-5) L: Jim Deshaies (4-9) | Sixth | 15 out |
| Saturday, August 10 |
| » Lost to Braves (58-50), 4-0 | Atlanta-Fulton County Stadium (2-3) | 46-63 | Lost 4 |
| » W: John Smoltz (8-12) L: Pete Harnisch (6-8) | Sixth | 15 out |
| Sunday, August 11 |
| » Lost to Braves (59-50), 3-1 | Atlanta-Fulton County Stadium (2-4) | 46-64 | Lost 5 |
| » W: Armando Reynoso (1-0) L: Darryl Kile (5-7) S: Mike Stanton (3) | Sixth | 15 out |
| » Major-league debuts: Armando Reynoso (Braves) |
| Monday, August 12 |
| » Lost to Padres (55-57), 6-5 | San Diego/Jack Murphy Stadium (0-5) | 46-65 | Lost 6 |
| » W: Jose Melendez (6-3) L: Mike Capel (1-3) S: Craig Lefferts (18) | Sixth | 16 out |
| Tuesday, August 13 |
| » Defeated Padres (55-58), 12-9 | San Diego/Jack Murphy Stadium (1-5) | 47-65 | |
| » W: Ryan Bowen (2-2) L: Mike Maddux (4-2) S: Al Osuna (9) | Sixth | 15 out |
| Wednesday, August 14 |
| » Lost to Padres (56-58), 4-1 | San Diego/Jack Murphy Stadium (1-6) | 47-66 | |
| » W: Dennis Rasmussen (4-10) L: Jim Deshaies (4-10) S: Larry Andersen (8) | Sixth | 16 out |
| Thursday, August 15 |
| » Defeated Dodgers (63-51), 6-1 | Dodger Stadium (2-2) | 48-66 | |
| » W: Pete Harnisch (7-8) L: Ramon Martinez (14-8) | Sixth | 15 out |
| Friday, August 16 |
| » Lost to Dodgers (64-51), 4-1 | Dodger Stadium (2-3) | 48-67 | |
| » W: Kevin Gross (7-9) L: Jim Corsi (0-5) | Sixth | 16 out |
| Saturday, August 17 |
| » Lost to Dodgers (65-51), 8-7 | Dodger Stadium (2-4) | 48-68 | Lost 2 |
| » W: Jay Howell (5-4) L: Dwayne Henry (3-1) | Sixth | 17 out |
| Sunday, August 18 |
| » Defeated Dodgers (65-52), 8-4 | Dodger Stadium (3-4) | 49-68 | |
| » W: Mark Portugal (9-5) L: Mike Morgan (10-7) S: Rob Mallicoat (1) | Sixth | 16 out |
| Tuesday, August 20 |
| » Lost to Giants (58-60), 9-3 | Astrodome (29-29) | 49-69 | |
| » W: Kelly Downs (10-4) L: Jimmy Jones (6-8) S: Jeff Brantley (11) | Fifth | 17½ out |
| Wednesday, August 21 |
| » Defeated Giants (58-61), 13-4 | Astrodome (30-29) | 50-69 | |
| » W: Pete Harnisch (8-8) L: Bud Black (9-12) | Fifth | 17½ out |
| Thursday, August 22 |
| » Lost to Giants (59-61), 11-8 | Astrodome (30-30) | 50-70 | |
| » W: Jeff Brantley (5-2) L: Darryl Kile (5-8) S: Dave Righetti (20) | Sixth | 18 out |
| Friday, August 23 |
| » Defeated Expos (48-72), 9-2 | Astrodome (31-30) | 51-70 | |
| » W: Ryan Bowen (3-2) L: Dennis Martinez (12-8) | Fifth | 17 out |
| Saturday, August 24 |
| » Lost to Expos (49-72), 5-1 | Astrodome (31-31) | 51-71 | |
| » W: Mel Rojas (1-3) L: Mark Portugal (9-6) | Fifth | 17 out |
| Sunday, August 25 |
| » Lost to Expos (50-72), 4-0 | Astrodome (31-32) | 51-72 | Lost 2 |
| » W: Mark Gardner (7-9) L: Jim Deshaies (4-11) S: Jeff Fassero (6) | Fifth | 17 out |
| Monday, August 26 |
| » Lost to Mets (61-63), 6-4 | Astrodome (31-33) | 51-73 | Lost 3 |
| » W: John Franco (3-7) L: Dwayne Henry (3-2) | Sixth | 18 out |
| Tuesday, August 27 |
| » Defeated Mets (61-64), 8-3 | Astrodome (32-33) | 52-73 | |
| » W: Darryl Kile (6-8) L: Wally Whitehurst (5-10) S: Curt Schilling (6) | Fifth | 17 out |
| Wednesday, August 28 |
| » Lost to Phillies (61-65), 11-10 | Veteran's Stadium (2-3) | 52-74 | |
| » W: Mike Hartley (4-1) L: Al Osuna (7-4) | Sixth | 18 out |
| Thursday, August 29 |
| » Defeated Phillies (61-66), 5-1 | Veteran's Stadium (3-3) | 53-74 | |
| » W: Mark Portugal (10-6) L: Danny Cox (4-6) | Sixth | 18 out |
| Friday, August 30 |
| » Lost to Expos (51-76), 3-1 | Stade Olympique (0-4) | 53-75 | |
| » W: Mark Gardner (8-9) L: Jim Deshaies (4-12) S: Barry Jones (10) | Sixth | 19 out |
| Saturday, August 31 |
| » Lost to Expos (52-76), 5-4 | Stade Olympique (0-5) | 53-76 | Lost 2 |
| » W: Jeff Fassero (2-4) L: Al Osuna (7-5) | Sixth | 19 out |
| » Major-league debuts: Andy Mota (Astros) |
| Sunday, September 1 |
| » Lost to Expos (53-76), 6-1 | Stade Olympique (0-6) | 53-77 | Lost 3 |
| » W: Chris Nabholz (3-7) L: Darryl Kile (6-9) | Fifth | 19 out |
| Monday, September 2 |
| » Defeated Mets (64-67), 3-0 | Shea Stadium (3-1) | 54-77 | |
| » W: Ryan Bowen (4-2) L: Frank Viola (12-13) S: Al Osuna (10) | Fifth | 18 out |
| Tuesday, September 3 |
| » Lost to Mets (65-67), 6-1 | Shea Stadium (3-2) | 54-78 | |
| » W: Anthony Young (1-1) L: Mark Portugal (10-7) | Fifth | 19 out |
| Wednesday, September 4 |
| » Defeated Mets (65-68), 8-3 | Shea Stadium (4-2) | 55-78 | |
| » W: Jim Deshaies (5-12) L: David Cone (12-11) | Sixth | 19 out |
| » Major-league debuts: Terry Bross (Mets) |
| Friday, September 6 |
| » Defeated Phillies (64-70), 3-1 | Astrodome (33-33) | 56-78 | Won 2 |
| » W: Pete Harnisch (9-8) L: Jose DeJesus (10-5) S: Al Osuna (11) | Sixth | 18½ out |
| Saturday, September 7 |
| » Defeated Phillies (64-71), 6-0 | Astrodome (34-33) | 57-78 | Won 3 |
| » W: Darryl Kile (7-9) L: Bruce Ruffin (3-6) | Sixth | 18½ out |
| Sunday, September 8 |
| » Lost to Phillies (65-71), 5-0 | Astrodome (34-34) | 57-79 | |
| » W: Terry Mulholland (14-11) L: Ryan Bowen (4-3) | Sixth | 19½ out |
| » Major-league debuts: Kim Batiste (Phillies) |
| Monday, September 9 |
| » Lost to Padres (70-68), 3-0 | Astrodome (34-35) | 57-80 | Lost 2 |
| » W: Andy Benes (12-10) L: Mark Portugal (10-8) S: Craig Lefferts (20) | Sixth | 20½ out |
| Tuesday, September 10 |
| » Lost to Padres (71-68), 7-6 | Astrodome (34-36) | 57-81 | Lost 3 |
| » W: Dennis Rasmussen (6-11) L: Chris Gardner (0-1) S: Craig Lefferts (21) | Sixth | 21 out |
| » Major-league debuts: Chris Gardner (Astros) |
| Wednesday, September 11 |
| » Lost to Dodgers (79-61), 9-1 | Astrodome (34-37) | 57-82 | Lost 4 |
| » W: Orel Hershiser (6-2) L: Pete Harnisch (9-9) | Sixth | 22 out |
| Thursday, September 12 |
| » Lost to Dodgers (80-61), 6-2 | Astrodome (34-38) | 57-83 | Lost 5 |
| » W: Roger McDowell (8-8) L: Al Osuna (7-6) | Sixth | 23 out |
| Friday, September 13 |
| » Lost to Reds (69-72), 13-2 | Riverfront Stadium (2-5) | 57-84 | Lost 6 |
| » W: Jack Armstrong (7-11) L: Ryan Bowen (4-4) | Sixth | 23½ out |
| Saturday, September 14 |
| » Defeated Reds (69-73), 7-3 | Riverfront Stadium (3-5) | 58-84 | |
| » W: Xavier Hernandez (1-6) L: Rob Dibble (3-4) S: Curt Schilling (7) | Sixth | 23 out |
| » Major-league debuts: Kenny Lofton (Astros) |
| Sunday, September 15 |
| » Lost to Reds (70-73), 10-0 | Riverfront Stadium (3-6) | 58-85 | |
| » W: Jose Rijo (14-4) L: Chris Gardner (0-2) | Sixth | 24 out |
| » Major-league debuts: Gary Cooper and Jeff Juden (Astros) |
| Monday, September 16 |
| » Lost to Padres (74-71), 6-1 | San Diego/Jack Murphy Stadium (1-7) | 58-86 | Lost 2 |
| » W: Greg Harris (6-5) L: Brian Williams (0-1) S: Larry Andersen (10) | Sixth | 24 out |
| » Major-league debuts: Brian Williams (Astros) |
| Tuesday, September 17 |
| » Defeated Padres (74-72), 3-0 | San Diego/Jack Murphy Stadium (2-7) | 59-86 | |
| » W: Pete Harnisch (10-9) L: Bruce Hurst (15-8) S: Xavier Hernandez (1) | Sixth | 23½ out |
| Wednesday, September 18 |
| » Lost to Dodgers (84-63), 5-4 | Dodger Stadium (3-5) | 59-87 | |
| » W: Mike Morgan (13-9) L: Rob Mallicoat (0-1) S: Steve Wilson (2) | Sixth | 24½ out |
| Thursday, September 19 |
| » Lost to Dodgers (85-63), 4-3 | Dodger Stadium (3-6) | 59-88 | Lost 2 |
| » W: Kevin Gross (10-10) L: Mark Portugal (10-9) S: Roger McDowell (7) | Sixth | 25½ out |
| Friday, September 20 |
| » Defeated Reds (70-78), 3-2 | Astrodome (35-38) | 60-88 | |
| » W: Ryan Bowen (5-4) L: Jose Rijo (14-5) S: Xavier Hernandez (2) | Sixth | 25 out |
| Saturday, September 21 |
| » Lost to Reds (71-78), 4-1 | Astrodome (35-39) | 60-89 | |
| » W: Scott Scudder (6-7) L: Jeff Juden (0-1) S: Rob Dibble (30) | Sixth | 25½ out |
| Sunday, September 22 |
| » Defeated Reds (71-79), 4-1 | Astrodome (36-39) | 61-89 | |
| » W: Xavier Hernandez (2-6) L: Tom Browning (14-12) S: Mark Portugal (1) | Sixth | 25½ out |
| Monday, September 23 |
| » Defeated Giants (69-82), 8-0 | Astrodome (37-39) | 62-89 | Won 2 |
| » W: Pete Harnisch (11-9) L: Trevor Wilson (11-11) S: Curt Schilling (8) | Sixth | 25 out |
| Tuesday, September 24 |
| » Lost to Giants (70-82), 9-7 | Astrodome (37-40) | 62-90 | |
| » W: Rod Beck (1-1) L: Mark Portugal (10-10) | Sixth | 26 out |
| Wednesday, September 25 |
| » Lost to Giants (71-82), 2-1 | Astrodome (37-41) | 62-91 | Lost 2 |
| » W: John Burkett (11-11) L: Darryl Kile (7-10) S: Jeff Brantley (13) | Sixth | 26 out |
| Friday, September 27 |
| » Lost to Braves (87-67), 4-2 | Astrodome (37-42) | 62-92 | Lost 3 |
| » W: Mark Wohlers (3-1) L: Rob Mallicoat (0-2) S: Alejandro Pena (11) | Sixth | 27 out |
| Saturday, September 28 |
| » Lost to Braves (88-67), 5-4 | Astrodome (37-43) | 62-93 | Lost 4 |
| » W: Mike Stanton (4-5) L: Xavier Hernandez (2-7) S: Alejandro Pena (12) | Sixth | 27 out |
| Sunday, September 29 |
| » Lost to Braves (89-67), 6-5 | Astrodome (37-44) | 62-94 | Lost 5 |
| » W: Jim Clancy (3-5) L: Mark Portugal (10-11) | Sixth | 28 out |
| Monday, September 30 |
| » Defeated Giants (72-85), 2-0 | Candlestick Park (4-3) | 63-94 | |
| » W: Chris Gardner (1-2) L: Gil Heredia (0-2) S: Xavier Hernandez (3) | Sixth | 28 out |
| Tuesday, October 1 |
| » Lost to Giants (73-85), 6-4 | Candlestick Park (4-4) | 63-95 | |
| » W: John Burkett (12-11) L: Darryl Kile (7-11) S: Jeff Brantley (14) | Sixth | 29 out |
| Wednesday, October 2 |
| » Defeated Giants (73-86), 7-5 | Candlestick Park (5-4) | 64-95 | |
| » W: Ryan Bowen (6-4) L: Paul McClellan (3-6) S: Al Osuna (12) | Fifth | 28 out |
| Friday, October 4 |
| » Lost to Braves (93-67), 5-2 | Atlanta-Fulton County Stadium (2-5) | 64-96 | |
| » W: Steve Avery (18-8) L: Jeff Juden (0-2) S: Alejandro Pena (15) | Fifth | 29 out |
| Saturday, October 5 |
| » Lost to Braves (94-67), 5-2 | Atlanta-Fulton County Stadium (2-6) | 64-97 | Lost 2 |
| » W: John Smoltz (14-13) L: Mark Portugal (10-12) | Sixth | 30 out |
| Sunday, October 6 |
| » Defeated Braves (94-68), 8-3 | Atlanta-Fulton County Stadium (3-6) | 65-97 | |
| » W: Pete Harnisch (12-9) L: Charlie Leibrandt (15-13) | Sixth | 29 out |
| Friday, October 25 |
| Former Astro George Brunet dies in Poza Rica, Mexico at the age of 57. |
Game information provided by Retrosheet (www.retrosheet.org) |