| Sunday, March 11 |
| Former White Sox Roy Schalk dies in Gainesville, TX at the age of 82. |
| Thursday, March 29 |
| Former White Sox Phil Masi dies in Mt.Prospect, IL at the age of 75. |
| Monday, April 9 |
| » Defeated Brewers (0-1), 2-1 | Comiskey Park I (1-0) | 1-0 | |
| » W: Barry Jones (1-0) L: Tony Fossas (0-1) S: Bobby Thigpen (1) | First | -- |
| » Major-league debuts: Scott Radinsky (White Sox) |
| Tuesday, April 10 |
| » Defeated Brewers (0-2), 5-3 | County Stadium (1-0) | 2-0 | Won 2 |
| » W: Scott Radinsky (1-0) L: Tom Filer (0-1) S: Bobby Thigpen (2) | First | -- |
| Friday, April 13 |
| » Lost to Indians (1-1), 6-2 | Comiskey Park I (1-1) | 2-1 | |
| » W: John Farrell (1-0) L: Bill Long (0-1) S: Doug Jones (1) | Second | ½ out |
| » Major-league debuts: Craig Grebeck (White Sox) |
| Saturday, April 14 |
| » Defeated Indians (1-2), 9-4 | Comiskey Park I (2-1) | 3-1 | |
| » W: Melido Perez (1-0) L: Greg Swindell (0-1) | Second | ½ out |
| » Major-league debuts: Carlos Baerga (Indians) |
| Sunday, April 15 |
| » Defeated Indians (1-3), 4-1 | Comiskey Park I (3-1) | 4-1 | Won 2 |
| » W: Greg Hibbard (1-0) L: Kevin Bearse (0-1) S: Bobby Thigpen (3) | Second | ½ out |
| » Major-league debuts: Kevin Bearse (Indians) |
| Tuesday, April 17 |
| » Defeated Red Sox (4-4), 2-1 | Comiskey Park I (4-1) | 5-1 | Won 3 |
| » W: Barry Jones (2-0) L: Lee Smith (0-1) | Second | ½ out |
| Wednesday, April 18 |
| » Lost to Red Sox (5-4), 7-5 | Comiskey Park I (4-2) | 5-2 | |
| » W: Roger Clemens (3-0) L: Jack McDowell (0-1) S: Lee Smith (4) | Second | 1½ out |
| Saturday, April 21 |
| » Lost to Indians (4-5), 8-4 | Cleveland Stadium (0-1) | 5-3 | Lost 2 |
| » W: Tom Candiotti (2-0) L: Melido Perez (1-1) | Second | 2½ out |
| Sunday, April 22 |
| » Lost to Indians (5-5), 5-2 | Cleveland Stadium (0-2) | 5-4 | Lost 3 |
| » W: Bud Black (1-0) L: Greg Hibbard (1-1) S: Doug Jones (4) | Second | 2½ out |
| Tuesday, April 24 |
| » Lost to Rangers (8-6), 5-4 | Arlington Stadium (0-1) | 5-5 | Lost 4 |
| » W: Kenny Rogers (1-0) L: Bobby Thigpen (0-1) | Third | 3½ out |
| Wednesday, April 25 |
| » Defeated Rangers (8-7), 5-4 | Arlington Stadium (1-1) | 6-5 | |
| » W: Jack McDowell (1-1) L: Bobby Witt (0-3) S: Bobby Thigpen (4) | Second | 3½ out |
| Thursday, April 26 |
| » Lost to Rangers (9-7), 1-0 | Arlington Stadium (1-2) | 6-6 | |
| » W: Nolan Ryan (4-0) L: Melido Perez (1-2) | Third | 4½ out |
| Friday, April 27 |
| » Defeated Blue Jays (11-7), 6-1 | Comiskey Park I (5-2) | 7-6 | |
| » W: Greg Hibbard (2-1) L: John Cerutti (1-3) | Third | 3½ out |
| Saturday, April 28 |
| » Defeated Blue Jays (11-8), 5-4 | Comiskey Park I (6-2) | 8-6 | Won 2 |
| » W: Jerry Kutzler (1-0) L: Mike Flanagan (2-1) S: Bobby Thigpen (5) | Third | 2½ out |
| » Major-league debuts: Jerry Kutzler (White Sox) |
| Sunday, April 29 |
| » Defeated Blue Jays (11-9), 10-3 | Comiskey Park I (7-2) | 9-6 | Won 3 |
| » W: Eric King (1-0) L: Jimmy Key (2-1) S: Wayne Edwards (1) | Second | 2½ out |
| Monday, April 30 |
| » Defeated Rangers (11-9), 5-4 | Comiskey Park I (8-2) | 10-6 | Won 4 |
| » W: Bobby Thigpen (1-1) L: Jamie Moyer (0-3) | Second | 2½ out |
| » Major-league debuts: Rodney McCray (White Sox) |
| Tuesday, May 1 |
| » Defeated Rangers (11-10), 5-1 | Comiskey Park I (9-2) | 11-6 | Won 5 |
| » W: Melido Perez (2-2) L: Nolan Ryan (4-1) S: Scott Radinsky (1) | Second | 2½ out |
| Wednesday, May 2 |
| » Lost to Rangers (12-10), 6-3 | Comiskey Park I (9-3) | 11-7 | |
| » W: Charlie Hough (2-1) L: Greg Hibbard (2-2) | Second | 3½ out |
| Friday, May 4 |
| » Defeated Royals (6-15), 5-4 | Royals Stadium (1-0) | 12-7 | |
| » W: Barry Jones (3-0) L: Steve Farr (1-1) S: Bobby Thigpen (6) | Second | 3½ out |
| Saturday, May 5 |
| » Defeated Royals (6-16), 6-0 | Royals Stadium (2-0) | 13-7 | Won 2 |
| » W: Eric King (2-0) L: Richard Dotson (0-2) | Second | 2½ out |
| Sunday, May 6 |
| » Lost to Royals (7-16), 7-6 | Royals Stadium (2-1) | 13-8 | |
| » W: Steve Farr (2-1) L: Bobby Thigpen (1-2) | Second | 3½ out |
| Monday, May 7 |
| » Lost to Blue Jays (16-11), 6-1 | Skydome (0-1) | 13-9 | Lost 2 |
| » W: Dave Stieb (5-1) L: Jack McDowell (1-2) | Second | 4½ out |
| Tuesday, May 8 |
| » Defeated Blue Jays (16-12), 4-1 | Skydome (1-1) | 14-9 | |
| » W: Greg Hibbard (3-2) L: John Cerutti (1-5) S: Bobby Thigpen (7) | Second | 4½ out |
| » Major-league debuts: Carlos Diaz (Blue Jays) |
| Wednesday, May 9 |
| » Lost to Blue Jays (17-12), 4-3 | Skydome (1-2) | 14-10 | |
| » W: Frank Wills (2-1) L: Wayne Edwards (0-1) S: Duane Ward (4) | Second | 5½ out |
| Friday, May 11 |
| » Defeated Royals (10-18), 6-4 | Comiskey Park I (10-3) | 15-10 | |
| » W: Barry Jones (4-0) L: Mark Davis (0-2) S: Bobby Thigpen (8) | Second | 5½ out |
| Saturday, May 12 |
| » Defeated Royals (10-19), 6-3 | Comiskey Park I (11-3) | 16-10 | Won 2 |
| » W: Melido Perez (3-2) L: Richard Dotson (0-3) S: Scott Radinsky (2) | Second | 4½ out |
| Sunday, May 13 |
| » Defeated Royals (10-20), 4-3 | Comiskey Park I (12-3) | 17-10 | Won 3 |
| » W: Scott Radinsky (2-0) L: Jeff Montgomery (3-2) | Second | 3½ out |
| Tuesday, May 15 |
| » Defeated Orioles (14-18), 3-2 | Comiskey Park I (13-3) | 18-10 | Won 4 |
| » W: Barry Jones (5-0) L: Pete Harnisch (3-1) S: Bobby Thigpen (9) | Second | 2 out |
| Wednesday, May 16 |
| » Defeated Orioles (14-19), 4-2 | Comiskey Park I (14-3) | 19-10 | Won 5 |
| » W: Jerry Kutzler (2-0) L: Bob Milacki (1-2) S: Bobby Thigpen (10) | Second | 2 out |
| Thursday, May 17 |
| » Defeated Orioles (14-20), 7-3 | Comiskey Park I (15-3) | 20-10 | Won 6 |
| » W: Barry Jones (6-0) L: Brian Holton (1-1) | Second | 1½ out |
| Friday, May 18 |
| » Lost to Tigers (15-22), 8-2 | Comiskey Park I (15-4) | 20-11 | |
| » W: Brian DuBois (1-2) L: Melido Perez (3-3) | Second | 1½ out |
| Saturday, May 19 |
| » Lost to Tigers (16-22), 6-4 | Comiskey Park I (15-5) | 20-12 | Lost 2 |
| » W: Frank Tanana (3-2) L: Jack McDowell (1-3) S: Mike Henneman (9) | Second | 2½ out |
| Sunday, May 20 |
| » Lost to Tigers (17-22), 3-2 | Comiskey Park I (15-6) | 20-13 | Lost 3 |
| » W: Edwin Nunez (1-0) L: Wayne Edwards (0-2) S: Mike Henneman (10) | Second | 2½ out |
| Monday, May 21 |
| » Defeated Yankees (14-21), 6-5 | Yankee Stadium (1-0) | 21-13 | |
| » W: Scott Radinsky (3-0) L: Lee Guetterman (2-2) S: Bobby Thigpen (11) | Second | 2½ out |
| Tuesday, May 22 |
| » Lost to Yankees (15-21), 5-2 | Yankee Stadium (1-1) | 21-14 | |
| » W: Dave LaPoint (3-3) L: Melido Perez (3-4) S: Dave Righetti (8) | Second | 3½ out |
| Wednesday, May 23 |
| » Defeated Orioles (17-23), 6-3 | Memorial Stadium (1-0) | 22-14 | |
| » W: Eric King (3-0) L: Dave Johnson (3-3) S: Bobby Thigpen (12) | Second | 3½ out |
| Thursday, May 24 |
| » Defeated Orioles (17-24), 5-3 | Memorial Stadium (2-0) | 23-14 | Won 2 |
| » W: Scott Radinsky (4-0) L: Jay Tibbs (2-5) S: Bobby Thigpen (13) | Second | 3½ out |
| Friday, May 25 |
| » Lost to Tigers (20-24), 2-1 | Tiger Stadium (0-1) | 23-15 | |
| » W: Paul Gibson (1-1) L: Greg Hibbard (3-3) S: Mike Henneman (11) | Second | 4½ out |
| Saturday, May 26 |
| » Defeated Tigers (20-25), 10-4 | Tiger Stadium (1-1) | 24-15 | |
| » W: Ken Patterson (1-0) L: Jeff Robinson (4-4) | Second | 4½ out |
| Sunday, May 27 |
| » Defeated Tigers (20-26), 2-1 | Tiger Stadium (2-1) | 25-15 | Won 2 |
| » W: Melido Perez (4-4) L: Jack Morris (2-7) S: Bobby Thigpen (14) | Second | 4 out |
| Monday, May 28 |
| » Defeated Yankees (17-25), 2-1 | Comiskey Park I (16-6) | 26-15 | Won 3 |
| » W: Eric King (4-0) L: Tim Leary (3-5) S: Bobby Thigpen (15) | Second | 3 out |
| Tuesday, May 29 |
| » Defeated Yankees (17-26), 5-4 | Comiskey Park I (17-6) | 27-15 | Won 4 |
| » W: Bobby Thigpen (2-2) L: Jeff Robinson (0-3) | Second | 2 out |
| Wednesday, May 30 |
| » Defeated Yankees (17-27), 5-2 | Comiskey Park I (18-6) | 28-15 | Won 5 |
| » W: Greg Hibbard (4-3) L: Chuck Cary (2-1) S: Bobby Thigpen (16) | Second | 2 out |
| Thursday, May 31 |
| » Lost to Twins (28-19), 3-2 | Comiskey Park I (18-7) | 28-16 | |
| » W: Mark Guthrie (2-0) L: Jerry Kutzler (2-1) S: Rick Aguilera (14) | Second | 3 out |
| Friday, June 1 |
| » Defeated Twins (28-20), 2-1 | Comiskey Park I (19-7) | 29-16 | |
| » W: Barry Jones (7-0) L: Terry Leach (2-1) | Second | 3 out |
| Saturday, June 2 |
| » Lost to Twins (29-20), 2-1 | Comiskey Park I (19-8) | 29-17 | |
| » W: John Candelaria (6-1) L: Eric King (4-1) S: Rick Aguilera (15) | Second | 3 out |
| Sunday, June 3 |
| » Defeated Twins (29-21), 5-2 | Comiskey Park I (20-8) | 30-17 | |
| » W: Jack McDowell (2-3) L: Allan Anderson (2-7) S: Bobby Thigpen (17) | Second | 2 out |
| Tuesday, June 5 |
| » Lost to Mariners (25-28), 10-6 | Comiskey Park I (20-9) | 30-18 | |
| » W: Brian Holman (7-3) L: Greg Hibbard (4-4) | Second | 3 out |
| Wednesday, June 6 |
| » Defeated Mariners (25-29), 5-0 | Comiskey Park I (21-9) | 31-18 | |
| » W: Melido Perez (5-4) L: Matt Young (1-6) | Second | 3 out |
| Thursday, June 7 |
| » Lost to Mariners (26-29), 2-1 | Comiskey Park I (21-10) | 31-19 | |
| » W: Randy Johnson (5-3) L: Donn Pall (0-1) | Second | 3 out |
| Friday, June 8 |
| » Defeated Twins (30-24), 3-2 | Hubert H. Humphrey Metrodome (1-0) | 32-19 | |
| » W: Scott Radinsky (5-0) L: Juan Berenguer (4-1) S: Bobby Thigpen (18) | Second | 3 out |
| Saturday, June 9 |
| » Defeated Twins (30-25), 4-2 | Hubert H. Humphrey Metrodome (2-0) | 33-19 | Won 2 |
| » W: Eric King (5-1) L: Allan Anderson (2-8) S: Bobby Thigpen (19) | Second | 3 out |
| Sunday, June 10 |
| » Defeated Twins (30-26), 5-3 | Hubert H. Humphrey Metrodome (3-0) | 34-19 | Won 3 |
| » W: Greg Hibbard (5-4) L: Roy Smith (4-6) S: Bobby Thigpen (20) | Second | 3 out |
| Monday, June 11 |
| » Defeated Mariners (28-32), 3-1 | Kingdome (1-0) | 35-19 | Won 4 |
| » W: Melido Perez (6-4) L: Matt Young (1-7) S: Ken Patterson (1) | Second | 2 out |
| Tuesday, June 12 |
| » Lost to Mariners (29-32), 5-2 | Kingdome (1-1) | 35-20 | |
| » W: Randy Johnson (6-3) L: Adam Peterson (0-1) S: Mike Schooler (15) | Second | 2 out |
| Wednesday, June 13 |
| » Defeated Mariners (29-33), 11-2 | Kingdome (2-1) | 36-20 | |
| » W: Jack McDowell (3-3) L: Erik Hanson (6-5) | Second | 2 out |
| Thursday, June 14 |
| » Defeated Athletics (39-20), 3-2 | Comiskey Park I (22-10) | 37-20 | Won 2 |
| » W: Eric King (6-1) L: Dave Stewart (9-4) S: Bobby Thigpen (21) | Second | 1 out |
| Friday, June 15 |
| » Lost to Athletics (40-20), 5-4 | Comiskey Park I (22-11) | 37-21 | |
| » W: Bob Welch (10-2) L: Barry Jones (7-1) S: Dennis Eckersley (21) | Second | 2 out |
| Saturday, June 16 |
| » Lost to Athletics (41-20), 12-3 | Comiskey Park I (22-12) | 37-22 | Lost 2 |
| » W: Scott Sanderson (8-3) L: Melido Perez (6-5) | Second | 3 out |
| » Major-league debuts: Steve Howard (Athletics) |
| Sunday, June 17 |
| » Lost to Athletics (42-20), 5-2 | Comiskey Park I (22-13) | 37-23 | Lost 3 |
| » W: Mike Moore (5-6) L: Donn Pall (0-2) S: Dennis Eckersley (22) | Second | 4 out |
| Monday, June 18 |
| » Lost to Angels (33-32), 4-1 | Comiskey Park I (22-14) | 37-24 | Lost 4 |
| » W: Jim Abbott (4-5) L: Jack McDowell (3-4) S: Bryan Harvey (9) | Second | 4 out |
| Tuesday, June 19 |
| » Lost to Angels (34-32), 5-3 | Comiskey Park I (22-15) | 37-25 | Lost 5 |
| » W: Kirk McCaskill (5-3) L: Melido Perez (6-6) S: Mark Eichhorn (13) | Second | 4 out |
| Wednesday, June 20 |
| » Defeated Angels (34-33), 2-1 | Comiskey Park I (23-15) | 38-25 | |
| » W: Barry Jones (8-1) L: Mark Langston (4-7) S: Bobby Thigpen (22) | Second | 4 out |
| Friday, June 22 |
| » Defeated Athletics (43-23), 5-0 | Oakland-Alameda County Stadium (1-0) | 39-25 | Won 2 |
| » W: Eric King (7-1) L: Scott Sanderson (8-4) | Second | 3 out |
| Saturday, June 23 |
| » Defeated Athletics (43-24), 5-3 | Oakland-Alameda County Stadium (2-0) | 40-25 | Won 3 |
| » W: Jack McDowell (4-4) L: Mike Moore (5-7) S: Bobby Thigpen (23) | Second | 2 out |
| Sunday, June 24 |
| » Defeated Athletics (43-25), 3-2 | Oakland-Alameda County Stadium (3-0) | 41-25 | Won 4 |
| » W: Bobby Thigpen (3-2) L: Dave Stewart (9-6) S: Barry Jones (1) | Second | 1 out |
| Monday, June 25 |
| » Defeated Angels (37-35), 2-0 | Anaheim Stadium (1-0) | 42-25 | Won 5 |
| » W: Greg Hibbard (6-4) L: Mark Langston (4-8) S: Bobby Thigpen (24) | Second | 1 out |
| Tuesday, June 26 |
| » Defeated Angels (37-36), 11-9 | Anaheim Stadium (2-0) | 43-25 | Won 6 |
| » W: Barry Jones (9-1) L: Mark Eichhorn (0-4) S: Bobby Thigpen (25) | Second | 1 out |
| Wednesday, June 27 |
| » Defeated Angels (37-37), 5-2 | Anaheim Stadium (3-0) | 44-25 | Won 7 |
| » W: Eric King (8-1) L: Chuck Finley (10-4) S: Scott Radinsky (3) | First | -- |
| Friday, June 29 |
| » Defeated Yankees (27-44), 1-0 | Comiskey Park I (24-15) | 45-25 | Won 8 |
| » W: Jack McDowell (5-4) L: Chuck Cary (4-4) S: Bobby Thigpen (26) | First | -- |
| » Major-league debuts: Kevin Maas (Yankees) |
| Saturday, June 30 |
| » Lost to Yankees (28-44), 10-7 | Comiskey Park I (24-16) | 45-26 | |
| » W: Jeff Robinson (1-5) L: Melido Perez (6-7) S: Dave Righetti (16) | Second | 1 out |
| Sunday, July 1 |
| » Defeated Yankees (28-45), 4-0 | Comiskey Park I (25-16) | 46-26 | |
| » W: Barry Jones (10-1) L: Andy Hawkins (1-5) | First | -- |
| Monday, July 2 |
| » Defeated Tigers (37-42), 5-4 | Comiskey Park I (26-16) | 47-26 | Won 2 |
| » W: Bobby Thigpen (4-2) L: Mike Henneman (4-5) | First | -- |
| Tuesday, July 3 |
| » Lost to Tigers (38-42), 13-7 | Comiskey Park I (26-17) | 47-27 | |
| » W: Edwin Nunez (3-0) L: Eric King (8-2) S: Jerry Don Gleaton (2) | Second | 1 out |
| Wednesday, July 4 |
| » Lost to Tigers (39-42), 10-7 | Comiskey Park I (26-18) | 47-28 | Lost 2 |
| » W: Lance McCullers (2-0) L: Ken Patterson (1-1) | Second | 1 out |
| Friday, July 6 |
| » Defeated Orioles (35-45), 4-2 | Comiskey Park I (27-18) | 48-28 | |
| » W: Melido Perez (7-7) L: Pete Harnisch (7-5) S: Bobby Thigpen (27) | First | -- |
| Saturday, July 7 |
| » Lost to Orioles (36-45), 4-1 | Comiskey Park I (27-19) | 48-29 | |
| » W: John Mitchell (1-2) L: Greg Hibbard (6-5) S: Gregg Olson (16) | First | -- |
| Sunday, July 8 |
| » Lost to Orioles (37-45), 8-6 | Comiskey Park I (27-20) | 48-30 | Lost 2 |
| » W: Mark Williamson (5-1) L: Bobby Thigpen (4-3) S: Gregg Olson (17) | Second | 2 out |
| Wednesday, July 11 |
| » Lost to Brewers (37-44), 12-9 | Comiskey Park I (27-21) | 48-31 | Lost 3 |
| » W: Dan Plesac (1-3) L: Donn Pall (0-3) | Second | 2 out |
| Thursday, July 12 |
| » Defeated Yankees (30-51), 8-0 | Yankee Stadium (2-1) | 49-31 | |
| » W: Melido Perez (8-7) L: Andy Hawkins (1-7) | Second | 2 out |
| Friday, July 13 |
| » Defeated Yankees (30-52), 3-2 | Yankee Stadium (3-1) | 50-31 | Won 2 |
| » W: Greg Hibbard (7-5) L: Chuck Cary (4-5) S: Bobby Thigpen (28) | Second | 2 out |
| Saturday, July 14 |
| » Defeated Yankees (30-53), 8-7 | Yankee Stadium (4-1) | 51-31 | Won 3 |
| » W: Donn Pall (1-3) L: Lee Guetterman (6-4) S: Bobby Thigpen (29) | Second | 2 out |
| Sunday, July 15 |
| » Defeated Yankees (30-54), 8-5 | Yankee Stadium (5-1) | 52-31 | Won 4 |
| » W: Ken Patterson (2-1) L: Alan Mills (1-3) S: Bobby Thigpen (30) | Second | 2 out |
| Monday, July 16 |
| » Lost to Tigers (43-47), 5-4 | Tiger Stadium (2-2) | 52-32 | |
| » W: Mike Henneman (5-5) L: Donn Pall (1-4) | Second | 2 out |
| Tuesday, July 17 |
| » Defeated Tigers (43-48), 7-3 | Tiger Stadium (3-2) | 53-32 | |
| » W: Melido Perez (9-7) L: Jack Morris (8-11) | Second | 2 out |
| Wednesday, July 18 |
| » Defeated Tigers (43-49), 7-5 | Tiger Stadium (4-2) | 54-32 | Won 2 |
| » W: Donn Pall (2-4) L: Mike Henneman (5-6) S: Bobby Thigpen (31) | Second | 2½ out |
| Thursday, July 19 |
| » Lost to Orioles (43-48), 4-1 | Memorial Stadium (2-1) | 54-33 | |
| » W: John Mitchell (2-2) L: Adam Peterson (0-2) S: Gregg Olson (21) | Second | 2 out |
| Friday, July 20 |
| » Lost to Orioles (44-48), 3-2 | Memorial Stadium (2-2) | 54-34 | Lost 2 |
| » W: Mark Williamson (8-1) L: Bobby Thigpen (4-4) | Second | 2 out |
| Saturday, July 21 |
| » Lost to Orioles (45-48), 2-0 | Memorial Stadium (2-3) | 54-35 | Lost 3 |
| » W: Ben McDonald (1-0) L: Jack McDowell (5-5) | Second | 2 out |
| Sunday, July 22 |
| » Lost to Orioles (46-48), 9-3 | Memorial Stadium (2-4) | 54-36 | Lost 4 |
| » W: Pete Harnisch (9-5) L: Melido Perez (9-8) S: Curt Schilling (2) | Second | 3 out |
| Monday, July 23 |
| » Defeated Indians (45-49), 3-1 | Comiskey Park I (28-21) | 55-36 | |
| » W: Greg Hibbard (8-5) L: Tom Candiotti (10-6) S: Bobby Thigpen (32) | Second | 3 out |
| Tuesday, July 24 |
| » Defeated Indians (45-50), 8-3 | Comiskey Park I (29-21) | 56-36 | Won 2 |
| » W: Adam Peterson (1-2) L: Rod Nichols (0-3) S: Donn Pall (1) | Second | 3 out |
| Wednesday, July 25 |
| » Lost to Indians (46-50), 6-1 | Comiskey Park I (29-22) | 56-37 | |
| » W: Bud Black (9-5) L: Eric King (8-3) | Second | 4 out |
| Friday, July 27 |
| » Defeated Brewers (44-52), 7-4 | Comiskey Park I (30-22) | 57-37 | |
| » W: Jack McDowell (6-5) L: Ron Robinson (6-4) | Second | 2½ out |
| » Major-league debuts: Kevin Brown (Brewers) |
| Saturday, July 28 |
| » Defeated Brewers (44-53), 5-4 | Comiskey Park I (31-22) | 58-37 | Won 2 |
| » W: Scott Radinsky (6-0) L: Dan Plesac (2-4) | Second | 3 out |
| Sunday, July 29 |
| » Lost to Brewers (45-53), 9-8 | Comiskey Park I (31-23) | 58-38 | |
| » W: Paul Mirabella (3-2) L: Scott Radinsky (6-1) S: Tom Edens (1) | Second | 3 out |
| Monday, July 30 |
| » Lost to Red Sox (54-48), 3-0 | Fenway Park (0-1) | 58-39 | Lost 2 |
| » W: Roger Clemens (14-5) L: Adam Peterson (1-3) | Second | 3 out |
| Tuesday, July 31 |
| » Lost to Red Sox (55-48), 7-2 | Fenway Park (0-2) | 58-40 | Lost 3 |
| » W: Dana Kiecker (4-4) L: Eric King (8-4) | Second | 3 out |
| Wednesday, August 1 |
| » Lost to Red Sox (56-48), 9-5 | Fenway Park (0-3) | 58-41 | Lost 4 |
| » W: Tom Bolton (5-1) L: Jack McDowell (6-6) | Second | 4 out |
| Thursday, August 2 |
| » Defeated Brewers (45-57), 4-3 | County Stadium (2-0) | 59-41 | |
| » W: Barry Jones (11-1) L: Randy Veres (0-3) S: Bobby Thigpen (33) | Second | 3½ out |
| » Defeated Brewers (45-58), 4-2 | County Stadium (3-0) | 60-41 | Won 2 |
| » W: Melido Perez (10-8) L: Jaime Navarro (2-3) S: Bobby Thigpen (34) | Second | 3½ out |
| » Major-league debuts: Alex Fernandez and Frank Thomas (White Sox) |
| Friday, August 3 |
| » Defeated Brewers (45-59), 6-2 | County Stadium (4-0) | 61-41 | Won 3 |
| » W: Greg Hibbard (9-5) L: Mark Knudson (8-5) | Second | 3½ out |
| Saturday, August 4 |
| » Defeated Brewers (45-60), 9-6 | County Stadium (5-0) | 62-41 | Won 4 |
| » W: Adam Peterson (2-3) L: Bill Krueger (5-7) S: Bobby Thigpen (35) | Second | 2½ out |
| Sunday, August 5 |
| » Defeated Brewers (45-61), 6-1 | County Stadium (6-0) | 63-41 | Won 5 |
| » W: Jack McDowell (7-6) L: Dennis Powell (0-3) | Second | 2½ out |
| Monday, August 6 |
| » Lost to Royals (50-57), 5-4 | Royals Stadium (2-2) | 63-42 | |
| » W: Storm Davis (5-7) L: Melido Perez (10-9) S: Jeff Montgomery (16) | Second | 3 out |
| Tuesday, August 7 |
| » Defeated Royals (50-58), 5-3 | Royals Stadium (3-2) | 64-42 | |
| » W: Alex Fernandez (1-0) L: Pete Filson (0-3) S: Bobby Thigpen (36) | Second | 3 out |
| » Major-league debuts: Brian McRae (Royals) |
| Wednesday, August 8 |
| » Lost to Royals (51-58), 5-1 | Royals Stadium (3-3) | 64-43 | |
| » W: Tom Gordon (7-8) L: Greg Hibbard (9-6) | Second | 3 out |
| Thursday, August 9 |
| » Lost to Royals (52-58), 5-3 | Royals Stadium (3-4) | 64-44 | Lost 2 |
| » W: Kevin Appier (7-4) L: Adam Peterson (2-4) S: Steve Farr (1) | Second | 4 out |
| Friday, August 10 |
| » Defeated Rangers (58-54), 5-2 | Comiskey Park I (32-23) | 65-44 | |
| » W: Jack McDowell (8-6) L: Craig McMurtry (0-2) S: Bobby Thigpen (37) | Second | 3½ out |
| » Defeated Rangers (58-55), 5-1 | Comiskey Park I (33-23) | 66-44 | Won 2 |
| » W: Wayne Edwards (1-2) L: Nolan Ryan (11-6) S: Scott Radinsky (4) | Second | 3½ out |
| Saturday, August 11 |
| » Lost to Rangers (59-55), 7-5 | Comiskey Park I (33-24) | 66-45 | |
| » W: Charlie Hough (10-7) L: Melido Perez (10-10) S: Kenny Rogers (12) | Second | 4½ out |
| Monday, August 13 |
| » Lost to Blue Jays (61-55), 4-3 | Comiskey Park I (33-25) | 66-46 | Lost 2 |
| » W: Duane Ward (2-6) L: Bobby Thigpen (4-5) S: Tom Henke (25) | Second | 6 out |
| Tuesday, August 14 |
| » Lost to Blue Jays (62-55), 12-4 | Comiskey Park I (33-26) | 66-47 | Lost 3 |
| » W: Todd Stottlemyre (11-13) L: Greg Hibbard (9-7) | Second | 6 out |
| » Major-league debuts: Bob MacDonald (Blue Jays) |
| Wednesday, August 15 |
| » Defeated Blue Jays (62-56), 4-3 | Comiskey Park I (34-26) | 67-47 | |
| » W: Jack McDowell (9-6) L: John Candelaria (7-5) S: Bobby Thigpen (38) | Second | 6 out |
| Friday, August 17 |
| » Lost to Rangers (61-57), 1-0 | Arlington Stadium (1-3) | 67-48 | |
| » W: Kenny Rogers (5-5) L: Donn Pall (2-5) | Second | 6½ out |
| » Defeated Rangers (61-58), 4-2 | Arlington Stadium (2-3) | 68-48 | |
| » W: Melido Perez (11-10) L: Charlie Hough (10-8) S: Bobby Thigpen (39) | Second | 6½ out |
| Saturday, August 18 |
| » Lost to Rangers (62-58), 8-3 | Arlington Stadium (2-4) | 68-49 | |
| » W: John Barfield (2-0) L: Alex Fernandez (1-1) | Second | 7½ out |
| Sunday, August 19 |
| » Defeated Rangers (62-59), 4-2 | Arlington Stadium (3-4) | 69-49 | |
| » W: Wayne Edwards (2-2) L: Jamie Moyer (1-5) S: Bobby Thigpen (40) | Second | 6½ out |
| Monday, August 20 |
| » Defeated Athletics (77-45), 11-1 | Comiskey Park I (35-26) | 70-49 | Won 2 |
| » W: Jack McDowell (10-6) L: Dave Stewart (17-9) | Second | 5½ out |
| Tuesday, August 21 |
| » Defeated Athletics (77-46), 4-1 | Comiskey Park I (36-26) | 71-49 | Won 3 |
| » W: Greg Hibbard (10-7) L: Mike Moore (10-12) S: Bobby Thigpen (41) | Second | 4½ out |
| » Major-league debuts: Darren Lewis (Athletics) |
| Wednesday, August 22 |
| » Lost to Athletics (78-46), 7-1 | Comiskey Park I (36-27) | 71-50 | |
| » W: Bob Welch (21-4) L: Melido Perez (11-11) | Second | 5½ out |
| Thursday, August 23 |
| » Defeated Angels (61-64), 4-2 | Comiskey Park I (37-27) | 72-50 | |
| » W: Alex Fernandez (2-1) L: Kirk McCaskill (9-9) S: Bobby Thigpen (42) | Second | 5 out |
| Friday, August 24 |
| » Defeated Angels (61-65), 5-2 | Comiskey Park I (38-27) | 73-50 | Won 2 |
| » W: Wayne Edwards (3-2) L: Jim Abbott (8-12) S: Bobby Thigpen (43) | Second | 5 out |
| Saturday, August 25 |
| » Lost to Angels (62-65), 3-2 | Comiskey Park I (38-28) | 73-51 | |
| » W: Mark Langston (8-15) L: Bobby Thigpen (4-6) S: Bryan Harvey (17) | Second | 5 out |
| Sunday, August 26 |
| » Lost to Angels (63-65), 4-1 | Comiskey Park I (38-29) | 73-52 | Lost 2 |
| » W: Joe Grahe (1-1) L: Greg Hibbard (10-8) S: Bryan Harvey (18) | Second | 5 out |
| Monday, August 27 |
| » Lost to Twins (57-71), 7-0 | Hubert H. Humphrey Metrodome (3-1) | 73-53 | Lost 3 |
| » W: Allan Anderson (6-16) L: Melido Perez (11-12) | Second | 5½ out |
| Tuesday, August 28 |
| » Lost to Twins (58-71), 12-6 | Hubert H. Humphrey Metrodome (3-2) | 73-54 | Lost 4 |
| » W: Tim Drummond (2-4) L: Adam Peterson (2-5) S: Gary Wayne (1) | Second | 6½ out |
| Wednesday, August 29 |
| » Lost to Twins (59-71), 6-1 | Hubert H. Humphrey Metrodome (3-3) | 73-55 | Lost 5 |
| » W: Mark Guthrie (5-7) L: Wayne Edwards (3-3) | Second | 6½ out |
| Thursday, August 30 |
| » Defeated Twins (59-72), 4-3 | Hubert H. Humphrey Metrodome (4-3) | 74-55 | |
| » W: Jack McDowell (11-6) L: David West (7-9) S: Bobby Thigpen (44) | Second | 6½ out |
| Friday, August 31 |
| » Defeated Angels (66-66), 6-5 | Anaheim Stadium (4-0) | 75-55 | Won 2 |
| » W: Greg Hibbard (11-8) L: Mark Langston (8-16) S: Bobby Thigpen (45) | Second | 6½ out |
| Saturday, September 1 |
| » Defeated Angels (66-67), 9-5 | Anaheim Stadium (5-0) | 76-55 | Won 3 |
| » W: Melido Perez (12-12) L: Joe Grahe (1-2) S: Bobby Thigpen (46) | Second | 5½ out |
| Sunday, September 2 |
| » Lost to Angels (67-67), 1-0 | Anaheim Stadium (5-1) | 76-56 | |
| » W: Chuck Finley (17-6) L: Alex Fernandez (2-2) S: Bryan Harvey (20) | Second | 6½ out |
| Monday, September 3 |
| » Defeated Royals (66-68), 4-2 | Comiskey Park I (39-29) | 77-56 | |
| » W: Wayne Edwards (4-3) L: Kevin Appier (11-5) S: Bobby Thigpen (47) | Second | 6½ out |
| Tuesday, September 4 |
| » Defeated Royals (66-69), 6-3 | Comiskey Park I (40-29) | 78-56 | Won 2 |
| » W: Jack McDowell (12-6) L: Andy McGaffigan (3-2) S: Bobby Thigpen (48) | Second | 6½ out |
| Wednesday, September 5 |
| » Defeated Royals (66-70), 3-0 | Comiskey Park I (41-29) | 79-56 | Won 3 |
| » W: Greg Hibbard (12-8) L: Steve Farr (10-6) | Second | 6½ out |
| Friday, September 7 |
| » Lost to Blue Jays (72-66), 3-1 | Skydome (1-3) | 79-57 | |
| » W: Todd Stottlemyre (13-14) L: Melido Perez (12-13) S: Tom Henke (27) | Second | 7½ out |
| Saturday, September 8 |
| » Lost to Blue Jays (73-66), 3-0 | Skydome (1-4) | 79-58 | Lost 2 |
| » W: Dave Stieb (18-5) L: Alex Fernandez (2-3) S: Tom Henke (28) | Second | 8½ out |
| Sunday, September 9 |
| » Lost to Blue Jays (74-66), 6-1 | Skydome (1-5) | 79-59 | Lost 3 |
| » W: Jimmy Key (10-7) L: Jack McDowell (12-7) | Second | 9½ out |
| Monday, September 10 |
| » Lost to Indians (63-78), 3-2 | Cleveland Stadium (0-3) | 79-60 | Lost 4 |
| » W: Doug Jones (5-5) L: Barry Jones (11-2) | Second | 9 out |
| » Defeated Indians (63-79), 6-2 | Cleveland Stadium (1-3) | 80-60 | |
| » W: Eric King (9-4) L: Charles Nagy (0-4) S: Bobby Thigpen (49) | Second | 9 out |
| » Major-league debuts: Turner Ward (Indians) |
| Tuesday, September 11 |
| » Lost to Indians (64-79), 4-3 | Cleveland Stadium (1-4) | 80-61 | |
| » W: Jesse Orosco (5-4) L: Barry Jones (11-3) | Second | 10 out |
| Wednesday, September 12 |
| » Lost to Indians (65-79), 12-2 | Cleveland Stadium (1-5) | 80-62 | Lost 2 |
| » W: Bud Black (11-10) L: Melido Perez (12-14) | Second | 11 out |
| Thursday, September 13 |
| » Defeated Red Sox (80-64), 9-6 | Comiskey Park I (42-29) | 81-62 | |
| » W: Alex Fernandez (3-3) L: Tom Bolton (9-3) S: Ken Patterson (2) | Second | 10 out |
| Friday, September 14 |
| » Defeated Red Sox (80-65), 4-0 | Comiskey Park I (43-29) | 82-62 | Won 2 |
|