| Monday, April 9 |
| » Lost to Dodgers (1-0), 4-2 | Dodger Stadium (0-1) | 0-1 | |
| » W: John Wetteland (1-0) L: Bruce Hurst (0-1) S: Don Aase (1) | Third | 1 out |
| Tuesday, April 10 |
| » Lost to Dodgers (2-0), 1-0 | San Diego/Jack Murphy Stadium (0-1) | 0-2 | Lost 2 |
| » W: Tim Belcher (1-0) L: Eric Show (0-1) | Third | 2 out |
| Wednesday, April 11 |
| » Defeated Dodgers (2-1), 3-1 | San Diego/Jack Murphy Stadium (1-1) | 1-2 | |
| » W: Andy Benes (1-0) L: Fernando Valenzuela (0-1) S: Craig Lefferts (1) | Fourth | 2 out |
| Thursday, April 12 |
| » Defeated Dodgers (2-2), 8-6 | San Diego/Jack Murphy Stadium (2-1) | 2-2 | Won 2 |
| » W: Calvin Schiraldi (1-0) L: Don Aase (0-1) S: Craig Lefferts (2) | Third | 1½ out |
| Friday, April 13 |
| » Defeated Giants (2-2), 8-3 | Candlestick Park (1-0) | 3-2 | Won 3 |
| » W: Greg Harris (1-0) L: Dan Quisenberry (0-1) | Second | 1½ out |
| Saturday, April 14 |
| » Defeated Giants (2-3), 5-3 | Candlestick Park (2-0) | 4-2 | Won 4 |
| » W: Craig Lefferts (1-0) L: Jeff Brantley (0-1) | Second | 1 out |
| Sunday, April 15 |
| » Defeated Giants (2-4), 4-3 | Candlestick Park (3-0) | 5-2 | Won 5 |
| » W: Greg Harris (2-0) L: Steve Bedrosian (0-1) | Second | 1 out |
| Tuesday, April 17 |
| » Lost to Reds (7-0), 2-1 | Riverfront Stadium (0-1) | 5-3 | |
| » W: Tom Browning (2-0) L: Andy Benes (1-1) S: Randy Myers (3) | Second | 2½ out |
| Wednesday, April 18 |
| » Lost to Reds (8-0), 11-7 | Riverfront Stadium (0-2) | 5-4 | Lost 2 |
| » W: Tim Layana (2-0) L: Rafael Valdez (0-1) S: Rob Dibble (2) | Third | 3½ out |
| » Major-league debuts: Rafael Valdez (Padres) |
| Friday, April 20 |
| » Defeated Giants (3-7), 9-2 | San Diego/Jack Murphy Stadium (3-1) | 6-4 | |
| » W: Ed Whitson (1-0) L: Rick Reuschel (1-1) | Second | 3 out |
| Saturday, April 21 |
| » Lost to Giants (4-7), 6-4 | San Diego/Jack Murphy Stadium (3-2) | 6-5 | |
| » W: Mike LaCoss (3-0) L: Bruce Hurst (0-2) S: Steve Bedrosian (1) | Second | 4 out |
| Sunday, April 22 |
| » Lost to Giants (5-7), 3-1 | San Diego/Jack Murphy Stadium (3-3) | 6-6 | Lost 2 |
| » W: Atlee Hammaker (1-1) L: Eric Show (0-2) S: Steve Bedrosian (2) | Third | 4 out |
| Monday, April 23 |
| » Defeated Giants (5-8), 13-3 | San Diego/Jack Murphy Stadium (4-3) | 7-6 | |
| » W: Andy Benes (2-1) L: Eric Gunderson (0-2) S: Calvin Schiraldi (1) | Third | 3½ out |
| Tuesday, April 24 |
| » Defeated Cubs (6-8), 13-3 | San Diego/Jack Murphy Stadium (5-3) | 8-6 | Won 2 |
| » W: Dennis Rasmussen (1-0) L: Greg Maddux (2-1) | Third | 2½ out |
| Wednesday, April 25 |
| » Defeated Cubs (6-9), 3-0 | San Diego/Jack Murphy Stadium (6-3) | 9-6 | Won 3 |
| » W: Ed Whitson (2-0) L: Mike Bielecki (0-2) | Second | 2½ out |
| Thursday, April 26 |
| » Lost to Cubs (7-9), 3-1 | San Diego/Jack Murphy Stadium (6-4) | 9-7 | |
| » W: Mike Harkey (2-1) L: Bruce Hurst (0-3) S: Mitch Williams (5) | Second | 3 out |
| Friday, April 27 |
| » Lost to Pirates (12-6), 9-4 | San Diego/Jack Murphy Stadium (6-5) | 9-8 | Lost 2 |
| » W: Neal Heaton (4-0) L: Eric Show (0-3) | Third | 4 out |
| Saturday, April 28 |
| » Lost to Pirates (13-6), 4-3 | San Diego/Jack Murphy Stadium (6-6) | 9-9 | Lost 3 |
| » W: Bob Walk (1-3) L: Andy Benes (2-2) S: Bill Landrum (3) | Third | 5 out |
| Sunday, April 29 |
| » Lost to Pirates (14-6), 10-1 | San Diego/Jack Murphy Stadium (6-7) | 9-10 | Lost 4 |
| » W: Doug Drabek (4-1) L: Dennis Rasmussen (1-1) | Third | 5 out |
| Tuesday, May 1 |
| » Lost to Cardinals (10-11), 2-1 | San Diego/Jack Murphy Stadium (6-8) | 9-11 | Lost 5 |
| » W: Bryn Smith (3-2) L: Ed Whitson (2-1) S: Scott Terry (2) | Third | 5½ out |
| Wednesday, May 2 |
| » Defeated Cardinals (10-12), 4-3 | San Diego/Jack Murphy Stadium (7-8) | 10-11 | |
| » W: Bruce Hurst (1-3) L: Jose DeLeon (2-1) S: Craig Lefferts (3) | Third | 4½ out |
| Saturday, May 5 |
| » Lost to Cubs (11-11), 3-2 | Wrigley Field (0-1) | 10-12 | |
| » W: Greg Maddux (4-1) L: Craig Lefferts (1-1) | Third | 6 out |
| » Defeated Cubs (11-12), 6-5 | Wrigley Field (1-1) | 11-12 | |
| » W: Dennis Rasmussen (2-1) L: Jose Nunez (1-3) S: Greg Harris (1) | Third | 6 out |
| Sunday, May 6 |
| » Defeated Cubs (11-13), 8-3 | Wrigley Field (2-1) | 12-12 | Won 2 |
| » W: Ed Whitson (3-1) L: Mike Bielecki (1-3) | Third | 6 out |
| Monday, May 7 |
| » Lost to Pirates (17-8), 4-1 | Three Rivers Stadium (0-1) | 12-13 | |
| » W: Bob Walk (2-3) L: Bruce Hurst (1-4) S: Ted Power (2) | Third | 7 out |
| Tuesday, May 8 |
| » Lost to Pirates (18-8), 10-2 | Three Rivers Stadium (0-2) | 12-14 | Lost 2 |
| » W: Walt Terrell (1-1) L: Eric Show (0-4) | Third | 7½ out |
| Wednesday, May 9 |
| » Lost to Cardinals (11-16), 11-5 | Busch Stadium II (0-1) | 12-15 | Lost 3 |
| » W: Ricky Horton (1-1) L: Andy Benes (2-3) | Third | 7½ out |
| Thursday, May 10 |
| » Defeated Cardinals (11-17), 9-1 | Busch Stadium II (1-1) | 13-15 | |
| » W: Dennis Rasmussen (3-1) L: Joe Magrane (0-6) | Third | 7½ out |
| Friday, May 11 |
| » Defeated Expos (17-13), 5-3 | San Diego/Jack Murphy Stadium (8-8) | 14-15 | Won 2 |
| » W: Craig Lefferts (2-1) L: Drew Hall (2-4) | Second | 7½ out |
| Saturday, May 12 |
| » Defeated Expos (17-14), 5-2 | San Diego/Jack Murphy Stadium (9-8) | 15-15 | Won 3 |
| » W: Bruce Hurst (2-4) L: Zane Smith (2-3) | Second | 6½ out |
| Sunday, May 13 |
| » Lost to Expos (18-14), 15-0 | San Diego/Jack Murphy Stadium (9-9) | 15-16 | |
| » W: Oil Can Boyd (2-2) L: Eric Show (0-5) | Second | 7½ out |
| Monday, May 14 |
| » Defeated Phillies (17-14), 5-1 | San Diego/Jack Murphy Stadium (10-9) | 16-16 | |
| » W: Andy Benes (3-3) L: Pat Combs (2-3) | Second | 7½ out |
| Tuesday, May 15 |
| » Lost to Phillies (18-14), 2-1 | San Diego/Jack Murphy Stadium (10-10) | 16-17 | |
| » W: Terry Mulholland (2-1) L: Dennis Rasmussen (3-2) S: Roger McDowell (8) | Second | 8½ out |
| Wednesday, May 16 |
| » Lost to Phillies (19-14), 6-5 | San Diego/Jack Murphy Stadium (10-11) | 16-18 | Lost 2 |
| » W: Ken Howell (4-3) L: Ed Whitson (3-2) S: Roger McDowell (9) | Third | 9 out |
| Friday, May 18 |
| » Defeated Mets (16-18), 6-3 | San Diego/Jack Murphy Stadium (11-11) | 17-18 | |
| » W: Bruce Hurst (3-4) L: Frank Viola (7-1) S: Craig Lefferts (4) | Third | 8½ out |
| » Major-league debuts: Todd Hundley (Mets) |
| Saturday, May 19 |
| » Lost to Mets (17-18), 6-4 | San Diego/Jack Murphy Stadium (11-12) | 17-19 | |
| » W: David Cone (1-2) L: Andy Benes (3-4) S: John Franco (8) | Third | 9½ out |
| Sunday, May 20 |
| » Defeated Mets (17-19), 3-1 | San Diego/Jack Murphy Stadium (12-12) | 18-19 | |
| » W: Greg Harris (3-0) L: Ron Darling (1-4) S: Craig Lefferts (5) | Third | 8½ out |
| Tuesday, May 22 |
| » Lost to Expos (21-18), 6-1 | Stade Olympique (0-1) | 18-20 | |
| » W: Mark Gardner (2-2) L: Ed Whitson (3-3) | Third | 9 out |
| Wednesday, May 23 |
| » Lost to Expos (22-18), 4-0 | Stade Olympique (0-2) | 18-21 | Lost 2 |
| » W: Oil Can Boyd (3-2) L: Bruce Hurst (3-5) | Third | 9½ out |
| Thursday, May 24 |
| » Defeated Mets (19-20), 5-4 | Shea Stadium (1-0) | 19-21 | |
| » W: Andy Benes (4-4) L: Frank Viola (7-2) S: Craig Lefferts (6) | Third | 9½ out |
| Friday, May 25 |
| » Defeated Mets (19-21), 5-4 | Shea Stadium (2-0) | 20-21 | Won 2 |
| » W: Dennis Rasmussen (4-2) L: David Cone (1-3) S: Craig Lefferts (7) | Third | 9½ out |
| Saturday, May 26 |
| » Lost to Mets (20-21), 11-0 | Shea Stadium (2-1) | 20-22 | |
| » W: Sid Fernandez (3-4) L: Mike Dunne (0-1) | Third | 10½ out |
| Sunday, May 27 |
| » Defeated Mets (20-22), 8-4 | Shea Stadium (3-1) | 21-22 | |
| » W: Ed Whitson (4-3) L: Dwight Gooden (3-4) S: Craig Lefferts (8) | Third | 9½ out |
| Monday, May 28 |
| » Defeated Phillies (24-19), 9-5 | Veteran's Stadium (1-0) | 22-22 | Won 2 |
| » W: Mark Grant (1-0) L: Jeff Parrett (2-3) | Third | 9 out |
| Wednesday, May 30 |
| » Defeated Phillies (24-20), 8-3 | Veteran's Stadium (2-0) | 23-22 | Won 3 |
| » W: Andy Benes (5-4) L: Bruce Ruffin (3-5) S: Greg Harris (2) | Third | 9 out |
| » Major-league debuts: Jim Vatcher (Phillies) |
| Thursday, May 31 |
| » Defeated Braves (17-27), 2-1 | San Diego/Jack Murphy Stadium (13-12) | 24-22 | Won 4 |
| » W: Dennis Rasmussen (5-2) L: Pete Smith (4-4) S: Greg Harris (3) | Second | 8 out |
| Friday, June 1 |
| » Lost to Braves (18-27), 16-11 | San Diego/Jack Murphy Stadium (13-13) | 24-23 | |
| » W: Tony Castillo (2-0) L: Mike Dunne (0-2) | Second | 9 out |
| Saturday, June 2 |
| » Defeated Braves (18-28), 9-0 | San Diego/Jack Murphy Stadium (14-13) | 25-23 | |
| » W: Ed Whitson (5-3) L: Derek Lilliquist (2-7) | Second | 9 out |
| Sunday, June 3 |
| » Lost to Braves (19-28), 4-2 | San Diego/Jack Murphy Stadium (14-14) | 25-24 | |
| » W: Charlie Kerfeld (3-2) L: Greg Harris (3-1) S: Joe Boever (6) | Second | 10 out |
| Monday, June 4 |
| » Defeated Astros (20-31), 10-2 | San Diego/Jack Murphy Stadium (15-14) | 26-24 | |
| » W: Andy Benes (6-4) L: Jim Clancy (1-5) S: Craig Lefferts (9) | Second | 9 out |
| Tuesday, June 5 |
| » Defeated Astros (20-32), 11-2 | San Diego/Jack Murphy Stadium (16-14) | 27-24 | Won 2 |
| » W: Dennis Rasmussen (6-2) L: Jim Deshaies (3-3) | Second | 8 out |
| Wednesday, June 6 |
| » Defeated Astros (20-33), 3-2 | San Diego/Jack Murphy Stadium (17-14) | 28-24 | Won 3 |
| » W: Craig Lefferts (3-1) L: Mark Portugal (1-6) | Second | 7 out |
| Friday, June 8 |
| » Defeated Dodgers (27-28), 12-6 | San Diego/Jack Murphy Stadium (18-14) | 29-24 | Won 4 |
| » W: Craig Lefferts (4-1) L: Jim Gott (0-1) | Second | 6½ out |
| Saturday, June 9 |
| » Lost to Dodgers (28-28), 5-4 | San Diego/Jack Murphy Stadium (18-15) | 29-25 | |
| » W: John Wetteland (2-4) L: Eric Show (0-6) | Second | 6½ out |
| Sunday, June 10 |
| » Defeated Dodgers (28-29), 2-1 | San Diego/Jack Murphy Stadium (19-15) | 30-25 | |
| » W: Greg Harris (4-1) L: Jay Howell (2-4) | Second | 5½ out |
| Tuesday, June 12 |
| » Lost to Giants (29-30), 7-2 | San Diego/Jack Murphy Stadium (19-16) | 30-26 | |
| » W: Don Robinson (2-0) L: Dennis Rasmussen (6-3) S: Mark Thurmond (2) | Second | 5 out |
| Wednesday, June 13 |
| » Lost to Giants (30-30), 6-0 | San Diego/Jack Murphy Stadium (19-17) | 30-27 | Lost 2 |
| » W: Trevor Wilson (2-0) L: Ed Whitson (5-4) | Second | 6 out |
| Thursday, June 14 |
| » Lost to Giants (31-30), 6-2 | San Diego/Jack Murphy Stadium (19-18) | 30-28 | Lost 3 |
| » W: Ed Vosberg (1-1) L: Bruce Hurst (3-6) | Second | 7 out |
| Friday, June 15 |
| » Defeated Dodgers (28-33), 3-1 | Dodger Stadium (1-1) | 31-28 | |
| » W: Calvin Schiraldi (2-0) L: Mike Hartley (0-1) | Second | 7 out |
| » Major-league debuts: Jim Poole (Dodgers) |
| Saturday, June 16 |
| » Lost to Dodgers (29-33), 5-2 | Dodger Stadium (1-2) | 31-29 | |
| » W: Ramon Martinez (7-3) L: Mike Dunne (0-3) | Third | 8 out |
| Sunday, June 17 |
| » Lost to Dodgers (30-33), 6-3 | Dodger Stadium (1-3) | 31-30 | Lost 2 |
| » W: Mike Morgan (7-5) L: Dennis Rasmussen (6-4) S: Jay Howell (2) | Third | 9 out |
| Monday, June 18 |
| » Lost to Giants (35-30), 2-1 | Candlestick Park (3-1) | 31-31 | Lost 3 |
| » W: Trevor Wilson (3-0) L: Ed Whitson (5-5) S: Jeff Brantley (8) | Third | 9½ out |
| Tuesday, June 19 |
| » Defeated Giants (35-31), 4-3 | Candlestick Park (4-1) | 32-31 | |
| » W: Bruce Hurst (4-6) L: Francisco Oliveras (0-1) S: Craig Lefferts (10) | Third | 9 out |
| Wednesday, June 20 |
| » Defeated Giants (35-32), 4-3 | Candlestick Park (5-1) | 33-31 | Won 2 |
| » W: Craig Lefferts (5-1) L: Steve Bedrosian (3-4) S: Greg Harris (4) | Third | 9 out |
| Saturday, June 23 |
| » Defeated Braves (25-41), 7-5 | Atlanta-Fulton County Stadium (1-0) | 34-31 | Won 3 |
| » W: Ed Whitson (6-5) L: Tom Glavine (3-5) S: Craig Lefferts (11) | Second | 8 out |
| Sunday, June 24 |
| » Lost to Braves (26-41), 11-10 | Atlanta-Fulton County Stadium (1-1) | 34-32 | |
| » W: Rick Luecken (1-2) L: Craig Lefferts (5-2) | Second | 9 out |
| Monday, June 25 |
| » Lost to Astros (29-41), 5-3 | Astrodome (0-1) | 34-33 | Lost 2 |
| » W: Mike Scott (5-7) L: Andy Benes (6-5) S: Dave Smith (15) | Third | 10 out |
| Tuesday, June 26 |
| » Defeated Astros (29-42), 7-0 | Astrodome (1-1) | 35-33 | |
| » W: Dennis Rasmussen (7-4) L: Jim Clancy (2-8) | Second | 10 out |
| Wednesday, June 27 |
| » Lost to Astros (30-42), 9-1 | Astrodome (1-2) | 35-34 | |
| » W: Jim Deshaies (4-5) L: Bruce Hurst (4-7) | Third | 10 out |
| Thursday, June 28 |
| » Lost to Astros (31-42), 2-1 | Astrodome (1-3) | 35-35 | Lost 2 |
| » W: Larry Andersen (4-1) L: Mark Grant (1-1) | Third | 10 out |
| Friday, June 29 |
| » Lost to Cubs (32-44), 3-2 | San Diego/Jack Murphy Stadium (19-19) | 35-36 | Lost 3 |
| » W: Bill Long (3-1) L: Greg Harris (4-2) S: Paul Assenmacher (3) | Third | 10 out |
| Saturday, June 30 |
| » Lost to Cubs (33-44), 7-3 | San Diego/Jack Murphy Stadium (19-20) | 35-37 | Lost 4 |
| » W: Steve Wilson (2-5) L: Andy Benes (6-6) | Third | 11 out |
| » Major-league debuts: Rich Rodriguez (Padres) |
| Sunday, July 1 |
| » Lost to Cubs (34-44), 11-10 | San Diego/Jack Murphy Stadium (19-21) | 35-38 | Lost 5 |
| » W: Les Lancaster (7-4) L: Craig Lefferts (5-3) S: Bill Long (1) | Fourth | 11 out |
| Monday, July 2 |
| » Lost to Pirates (45-30), 4-3 | San Diego/Jack Murphy Stadium (19-22) | 35-39 | Lost 6 |
| » W: Bob Patterson (5-3) L: Calvin Schiraldi (2-1) | Fourth | 11½ out |
| Tuesday, July 3 |
| » Lost to Pirates (46-30), 5-3 | San Diego/Jack Murphy Stadium (19-23) | 35-40 | Lost 7 |
| » W: Bill Landrum (3-1) L: Craig Lefferts (5-4) | Fourth | 12½ out |
| » Major-league debuts: Thomas Howard (Padres) |
| Wednesday, July 4 |
| » Defeated Pirates (46-31), 5-4 | San Diego/Jack Murphy Stadium (20-23) | 36-40 | |
| » W: Eric Show (1-6) L: Neal Heaton (10-4) S: Greg Harris (5) | Fourth | 11½ out |
| Thursday, July 5 |
| » Lost to Cardinals (33-47), 4-1 | San Diego/Jack Murphy Stadium (20-24) | 36-41 | |
| » W: Lee Smith (4-3) L: Greg Harris (4-3) | Fourth | 12½ out |
| Friday, July 6 |
| » Lost to Cardinals (34-47), 5-3 | San Diego/Jack Murphy Stadium (20-25) | 36-42 | Lost 2 |
| » W: John Tudor (7-3) L: Dennis Rasmussen (7-5) S: Lee Smith (15) | Fourth | 13½ out |
| Saturday, July 7 |
| » Defeated Cardinals (34-48), 3-1 | San Diego/Jack Murphy Stadium (21-25) | 37-42 | |
| » W: Bruce Hurst (5-7) L: Joe Magrane (4-12) | Fourth | 13½ out |
| Sunday, July 8 |
| » Lost to Cardinals (35-48), 4-1 | San Diego/Jack Murphy Stadium (21-26) | 37-43 | |
| » W: Bob Tewksbury (4-1) L: Ed Whitson (6-6) | Fourth | 13½ out |
| Thursday, July 12 |
| » Lost to Pirates (50-32), 4-3 | Three Rivers Stadium (0-3) | 37-44 | Lost 2 |
| » Manager: Greg Riddoch |
| » W: Bob Patterson (6-3) L: Calvin Schiraldi (2-2) | Fourth | 14 out |
| Friday, July 13 |
| » Lost to Pirates (51-32), 4-1 | Three Rivers Stadium (0-4) | 37-45 | Lost 3 |
| » W: Doug Drabek (10-4) L: Dennis Rasmussen (7-6) S: Stan Belinda (4) | Fourth | 15 out |
| Saturday, July 14 |
| » Lost to Pirates (52-32), 8-4 | Three Rivers Stadium (0-5) | 37-46 | Lost 4 |
| » W: Ted Power (1-2) L: Greg Harris (4-4) | Fourth | 15 out |
| Sunday, July 15 |
| » Defeated Pirates (52-33), 4-1 | Three Rivers Stadium (1-5) | 38-46 | |
| » W: Ed Whitson (7-6) L: Neal Heaton (10-5) S: Craig Lefferts (12) | Fourth | 15 out |
| Monday, July 16 |
| » Lost to Cubs (38-52), 4-3 | Wrigley Field (2-2) | 38-47 | |
| » W: Mike Harkey (7-4) L: Eric Show (1-7) S: Mitch Williams (10) | Fourth | 16 out |
| Tuesday, July 17 |
| » Lost to Cubs (39-52), 7-2 | Wrigley Field (2-3) | 38-48 | Lost 2 |
| » W: Shawn Boskie (4-5) L: Andy Benes (6-7) | Fourth | 17 out |
| Wednesday, July 18 |
| » Lost to Cubs (40-52), 4-2 | Wrigley Field (2-4) | 38-49 | Lost 3 |
| » W: Greg Maddux (5-9) L: Dennis Rasmussen (7-7) S: Jeff Pico (1) | Fourth | 18 out |
| Thursday, July 19 |
| » Lost to Cardinals (38-53), 8-3 | Busch Stadium II (1-2) | 38-50 | Lost 4 |
| » W: Joe Magrane (5-12) L: Bruce Hurst (5-8) S: Frank DiPino (1) | Fourth | 18 out |
| Friday, July 20 |
| » Lost to Cardinals (39-53), 4-2 | Busch Stadium II (1-3) | 38-51 | Lost 5 |
| » W: John Tudor (8-3) L: Ed Whitson (7-7) S: Lee Smith (17) | Fourth | 19 out |
| Saturday, July 21 |
| » Lost to Cardinals (40-53), 4-2 | Busch Stadium II (1-4) | 38-52 | Lost 6 |
| » W: Bob Tewksbury (5-2) L: Eric Show (1-8) S: Frank DiPino (2) | Fourth | 20 out |
| Sunday, July 22 |
| » Lost to Cardinals (41-53), 6-4 | Busch Stadium II (1-5) | 38-53 | Lost 7 |
| » W: Ken Dayley (2-2) L: Greg Harris (4-5) S: Lee Smith (18) | Fifth | 20 out |
| Monday, July 23 |
| » Lost to Reds (59-33), 9-2 | San Diego/Jack Murphy Stadium (21-27) | 38-54 | Lost 8 |
| » W: Tom Browning (10-5) L: Dennis Rasmussen (7-8) | Fifth | 21 out |
| Tuesday, July 24 |
| » Defeated Reds (59-34), 10-0 | San Diego/Jack Murphy Stadium (22-27) | 39-54 | |
| » W: Bruce Hurst (6-8) L: Jack Armstrong (11-6) | Fourth | 20 out |
| Wednesday, July 25 |
| » Defeated Reds (59-35), 2-1 | San Diego/Jack Murphy Stadium (23-27) | 40-54 | Won 2 |
| » W: Ed Whitson (8-7) L: Norm Charlton (8-5) S: Craig Lefferts (13) | Fourth | 18 out |
| » Defeated Reds (59-36), 10-4 | San Diego/Jack Murphy Stadium (24-27) | 41-54 | Won 3 |
| » W: Calvin Schiraldi (3-2) L: Rick Mahler (4-4) | Fourth | 18 out |
| Thursday, July 26 |
| » Defeated Astros (41-58), 8-2 | San Diego/Jack Murphy Stadium (25-27) | 42-54 | Won 4 |
| » W: Eric Show (2-8) L: Mark Portugal (4-9) | Fourth | 17 out |
| Friday, July 27 |
| » Defeated Astros (41-59), 6-2 | San Diego/Jack Murphy Stadium (26-27) | 43-54 | Won 5 |
| » W: Andy Benes (7-7) L: Bill Gullickson (6-8) | Fourth | 16 out |
| Saturday, July 28 |
| » Lost to Astros (42-59), 5-3 | San Diego/Jack Murphy Stadium (26-28) | 43-55 | |
| » W: Mike Scott (8-10) L: Dennis Rasmussen (7-9) S: Larry Andersen (4) | Fourth | 16 out |
| Sunday, July 29 |
| » Defeated Astros (42-60), 4-3 | San Diego/Jack Murphy Stadium (27-28) | 44-55 | |
| » W: Greg Harris (5-5) L: Dave Smith (2-3) S: Craig Lefferts (14) | Fourth | 15 out |
| Monday, July 30 |
| » Lost to Braves (40-60), 4-3 | San Diego/Jack Murphy Stadium (27-29) | 44-56 | |
| » W: Dwayne Henry (2-1) L: Calvin Schiraldi (3-3) S: Tony Castillo (1) | Fourth | 15 out |
| Tuesday, July 31 |
| » Defeated Braves (40-61), 7-6 | San Diego/Jack Murphy Stadium (28-29) | 45-56 | |
| » W: Craig Lefferts (6-4) L: Rick Luecken (1-4) | Fourth | 15 out |
| Wednesday, August 1 |
| » Lost to Reds (61-41), 6-3 | San Diego/Jack Murphy Stadium (28-30) | 45-57 | |
| » W: Scott Scudder (3-4) L: Andy Benes (7-8) | Fourth | 16 out |
| Thursday, August 2 |
| » Defeated Reds (61-42), 8-5 | Riverfront Stadium (1-2) | 46-57 | |
| » W: Dennis Rasmussen (8-9) L: Tom Browning (10-6) | Fourth | 15 out |
| Friday, August 3 |
| » Defeated Reds (61-43), 3-2 | Riverfront Stadium (2-2) | 47-57 | Won 2 |
| » W: Greg Harris (6-5) L: Rob Dibble (4-3) S: Craig Lefferts (15) | Fourth | 14 out |
| Saturday, August 4 |
| » Defeated Reds (61-44), 7-3 | Riverfront Stadium (3-2) | 48-57 | Won 3 |
| » W: Greg Harris (7-5) L: Rick Mahler (4-5) | Fourth | 13 out |
| Sunday, August 5 |
| » Lost to Reds (62-44), 6-2 | Riverfront Stadium (3-3) | 48-58 | |
| » W: Jose Rijo (8-4) L: Calvin Schiraldi (3-4) | Fourth | 14 out |
| Tuesday, August 7 |
| » Defeated Braves (40-66), 7-2 | Atlanta-Fulton County Stadium (2-1) | 49-58 | |
| » W: Andy Benes (8-8) L: Tom Glavine (6-8) S: Greg Harris (6) | Fourth | 13½ out |
| » Defeated Braves (40-67), 11-9 | Atlanta-Fulton County Stadium (3-1) | 50-58 | Won 2 |
| » W: Eric Show (3-8) L: Marty Clary (1-9) S: Craig Lefferts (16) | Fourth | 13½ out |
| Wednesday, August 8 |
| » Lost to Braves (41-67), 7-1 | Atlanta-Fulton County Stadium (3-2) | 50-59 | |
| » W: John Smoltz (8-8) L: Dennis Rasmussen (8-10) | Fourth | 13½ out |
| Thursday, August 9 |
| » Defeated Braves (41-68), 7-0 | Atlanta-Fulton County Stadium (4-2) | 51-59 | |
| » W: Bruce Hurst (7-8) L: Charlie Leibrandt (4-6) | Fourth | 12½ out |
| Friday, August 10 |
| » Defeated Astros (49-63), 2-0 | Astrodome (2-3) | 52-59 | Won 2 |
| » W: Ed Whitson (9-7) L: Jim Deshaies (5-10) S: Craig Lefferts (17) | Fourth | 12½ out |
| Saturday, August 11 |
| » Defeated Astros (49-64), 6-3 | Astrodome (3-3) | 53-59 | Won 3 |
| » W: Eric Show (4-8) L: Dave Smith (2-4) S: Craig Lefferts (18) | Fourth | 11½ out |
| Sunday, August 12 |
| » Defeated Astros (49-65), 9-0 | Astrodome (4-3) | 54-59 | Won 4 |
| » W: Derek Lilliquist (3-8) L: Bill Gullickson (8-9) | Fourth | 11½ out |
| Monday, August 13 |
| » Major-league debuts: Dave Walsh (Dodgers) |
| Tuesday, August 14 |
| » Lost to Expos (61-54), 8-3 | San Diego/Jack Murphy Stadium (28-31) | 54-60 | |
| » W: Dennis Martinez (9-8) L: Dennis Rasmussen (8-11) | Fourth | 13 out |
| Wednesday, August 15 |
| » Lost to Expos (62-54), 5-3 | San Diego/Jack Murphy Stadium (28-32) | 54-61 | Lost 2 |
| » W: Bill Sampen (10-4) L: John Davis (0-1) | Third | 14 out |
| Thursday, August 16 |
| » Defeated Expos (62-55), 3-2 | San Diego/Jack Murphy Stadium (29-32) | 55-61 | |
| » W: Rich Rodriguez (1-0) L: Tim Burke (1-3) | Third | 13½ out |
| Friday, August 17 |
| » Lost to Phillies (56-60), 2-1 | San Diego/Jack Murphy Stadium (29-33) | 55-62 | |
| » W: Jose DeJesus (4-4) L: Calvin Schiraldi (3-5) | Third | 13 out |
| Saturday, August 18 |
| » Defeated Phillies (56-61), 4-2 | San Diego/Jack Murphy Stadium (30-33) | 56-62 | |
| » W: Andy Benes (9-8) L: Tommy Greene (1-1) S: Craig Lefferts (19) | Fourth | 12 out |
| Sunday, August 19 |
| » Lost to Phillies (57-61), 3-2 | San Diego/Jack Murphy Stadium (30-34) | 56-63 | |
| » W: Joe Boever (2-3) L: Dennis Rasmussen (8-12) S: Roger McDowell (17) | Fourth | 12 out |
| Monday, August 20 |
| » Defeated Mets (68-51), 3-1 | San Diego/Jack Murphy Stadium (31-34) | 57-63 | |
| » W: Bruce Hurst (8-8) L: Sid Fernandez (8-10) S: Craig Lefferts (20) | Fourth | 11 out |
| Tuesday, August 21 |
| » Defeated Mets (68-52), 7-0 | San Diego/Jack Murphy Stadium (32-34) | 58-63 | Won 2 |
| » W: Ed Whitson (10-7) L: Ron Darling (5-8) | Fourth | 11 out |
| Wednesday, August 22 |
| » Lost to Mets (69-52), 4-1 | San Diego/Jack Murphy Stadium (32-35) | 58-64 | |
| » W: Frank Viola (16-8) L: Calvin Schiraldi (3-6) S: John Franco (29) | Fourth | 12 out |
| Friday, August 24 |
| » Defeated Expos (64-60), 2-1 | Stade Olympique (1-2) | 59-64 | |
| » W: Andy Benes (10-8) L: Dennis Martinez (10-9) S: Craig Lefferts (21) | Third | 11½ out |
| Saturday, August 25 |
| » Lost to Expos (65-60), 2-1 | Stade Olympique (1-3) | 59-65 | |
| » W: Chris Nabholz (2-0) L: Dennis Rasmussen (8-13) S: Mel Rojas (1) | Third | 12½ out |
| Sunday, August 26 |
| » Lost to Expos (66-60), 4-2 | Stade Olympique (1-4) | 59-66 | Lost 2 |
| » W: Steve Frey (6-2) L: Bruce Hurst (8-9) | Fourth | 13½ out |
| Monday, August 27 |
| » Defeated Expos (66-61), 4-1 | Stade Olympique (2-4) | 60-66 | |
| » W: Ed Whitson (11-7) L: Oil Can Boyd (7-5) S: Craig Lefferts (22) | Fourth | 13 out |
| Tuesday, August 28 |
| » Lost to Mets (71-55), 4-0 | Shea Stadium (3-2) | 60-67 | |
| » W: David Cone (10-7) L: Calvin Schiraldi (3-7) | Fourth | 14 out |
| Wednesday, August 29 |
| » Lost to Mets (72-55), 2-1 | Shea Stadium (3-3) | 60-68 | Lost 2 |
| » W: Bob Ojeda (7-5) L: Greg Harris (7-6) | Fourth | 14 out |
| Friday, August 31 |
| » Lost to Phillies (60-69), 4-2 | Veteran's Stadium (2-1) | 60-69 | Lost 3 |
| » W: Roger McDowell (6-6) L: Atlee Hammaker (4-6) | Fourth | 14½ out |
| » Major-league debuts: Wes Chamberlain (Phillies) |
| Saturday, September 1 |
| » Lost to Phillies (61-69), 3-2 | Veteran's Stadium (2-2) | 60-70 | Lost 4 |
| » W: Joe Boever (3-5) L: Greg Harris (7-7) | Fourth | 16 out |
| » Lost to Phillies (62-69), 2-1 | Veteran's Stadium (2-3) | 60-71 | Lost 5 |
| » W: Darrel Akerfelds (5-1) L: Rich Rodriguez (1-1) S: Roger McDowell (18) | Fourth | 16 out |
| » Major-league debuts: Mickey Morandini (Phillies) |
| Sunday, September 2 |
| » Defeated Phillies (62-70), 9-1 | Veteran's Stadium (3-3) | 61-71 | |
| » W: Ed Whitson (12-7) L: Jose DeJesus (4-6) | Fourth | 16 out |
| Monday, September 3 |
| » Lost to Giants (68-66), 5-4 | San Diego/Jack Murphy Stadium (32-36) | 61-72 | |
| » W: Kelly Downs (1-0) L: Calvin Schiraldi (3-8) S: Jeff Brantley (19) | Fourth | 16 out |
| Tuesday, September 4 |
| » Lost to Giants (69-66), 6-4 | San Diego/Jack Murphy Stadium (32-37) | 61-73 | Lost 2 |
| » W: Mike LaCoss (5-3) L: Atlee Hammaker (4-7) S: John Burkett (1) | Fifth | 16 out |
| Wednesday, September 5 |
| » Defeated Astros (62-74), 5-2 | San Diego/Jack Murphy Stadium (33-37) | 62-73 | |
| » W: Dennis Rasmussen (9-13) L: Mike Scott (9-13) S: Craig Lefferts (23) | Fourth | 16 out |
| » Major-league debuts: Mike Simms (Astros) |
| Thursday, September 6 |
| » Defeated Astros (62-75), 3-0 | San Diego/Jack Murphy Stadium (34-37) | 63-73 | Won 2 |
| » W: Greg Harris (8-7) L: Brian Meyer (0-1) | Fourth | 15 out |
| » Major-league debuts: Paul Faries (Padres) |
| Friday, September 7 |
| » Lost to Braves (57-81), 4-1 | San Diego/Jack Murphy Stadium (34-38) | 63-74 | |
| » W: Charlie Leibrandt (8-8) L: Ed Whitson (12-8) | Fourth | 15 out |
| Saturday, September 8 |
| » Lost to Braves (58-81), 11-5 | San Diego/Jack Murphy Stadium (34-39) | 63-75 | Lost 2 |
| » W: Jeff Parrett (5-9) L: Derek Lilliquist (3-9) | Fourth | 16 out |
| Sunday, September 9 |
| » Defeated Braves (58-82), 5-4 | San Diego/Jack Murphy Stadium (35-39) | 64-75 | |
| » W: Eric Show (5-8) L: Kent Mercker (4-4) | Fourth | 15 out |
| Monday, September 10 |
| » Defeated Dodgers (74-67), 5-2 | San Diego/Jack Murphy Stadium (36-39) | 65-75 | Won 2 |
| » W: Dennis Rasmussen (10-13) L: Tim Crews (2-5) S: Greg Harris (7) | Fourth | 14½ out |
| Tuesday, September 11 |
| » Defeated Dodgers (74-68), 4-0 | San Diego/Jack Murphy Stadium (37-39) | 66-75 | Won 3 |
| » W: Bruce Hurst (9-9) L: Mike Hartley (6-3) | Third | 14½ out |
| Wednesday, September 12 |
| » Lost to Dodgers (75-68), 10-3 | San Diego/Jack Murphy Stadium (37-40) | 66-76 | |
| » W: Tim Crews (3-5) L: Atlee Hammaker (4-8) S: Jay Howell (15) | Third | 14½ out |
| Friday, September 14 |
| » Lost to Braves (59-85), 7-3 | Atlanta-Fulton County Stadium (4-3) | 66-77 | Lost 2 |
| » W: Tom Glavine (8-11) L: Derek Lilliquist (3-10) S: Mark Grant (1) | Fourth | 15 out |
| Saturday, September 15 |
| » Defeated Braves (59-86), 5-3 | Atlanta-Fulton County Stadium (5-3) | 67-77 | |
| » W: Craig Lefferts (7-4) L: Jeff Parrett (5-10) S: Eric Show (1) | Fourth | 14 out |
| Sunday, September 16 |
| » Defeated Braves (59-87), 9-4 | Atlanta-Fulton County Stadium (6-3) | 68-77 | Won 2 |
| » W: Dennis Rasmussen (11-13) L: Steve Avery (3-9) | Fourth | 14 out |
| Monday, September 17 |
| » Defeated Astros (67-80), 5-0 | Astrodome (5-3) | 69-77 | Won 3 |
| » W: Bruce Hurst (10-9) L: Danny Darwin (11-3) | Fourth | 14 out |
| » Major-league debuts: Randy Hennis (Astros) |
| Tuesday, September 18 |
| » Defeated Astros (67-81), 8-1 | Astrodome (6-3) | 70-77 | Won 4 |
| » W: Ed Whitson (13-8) L: Bill Gullickson (9-13) | Fourth | 13 out |
| Wednesday, September 19 |
| » Defeated Dodgers (79-70), 9-4 | Dodger Stadium (2-3) | 71-77 | Won 5 |
| » W: Derek Lilliquist (4-10) L: Darren Holmes (0-1) S: Greg Harris (8) | Fourth | 12 out |
| Thursday, September 20 |
| » Lost to Dodgers (80-70), 7-2 | Dodger Stadium (2-4) | 71-78 | |
| » W: Ramon Martinez (19-6) L: Andy Benes (10-9) | Fourth | 12 out |
| Friday, September 21 |
| » Lost to Reds (84-66), 10-1 | San Diego/Jack Murphy Stadium (37-41) | 71-79 | Lost 2 |
| » W: Jose Rijo (13-7) L: Dennis Rasmussen (11-14) | Fourth | 13 out |
| Saturday, September 22 |
| » Lost to Reds (85-66), 6-4 | San Diego/Jack Murphy Stadium (37-42) | 71-80 | Lost 3 |
| » W: Rob Dibble (8-3) L: Greg Harris (8-8) S: Randy Myers (30) |