| Monday, January 1 |
| Former Cardinal Carmen Hill dies in Indianapolis, IN at the age of 95. |
| Tuesday, January 2 |
| Former Cardinal Bill Beckmann dies in Florissant, MO at the age of 83. |
| Thursday, March 1 |
| Former Cardinal Creepy Crespi dies in Florissant, MO at the age of 73. |
| Monday, April 9 |
| » Defeated Expos (0-1), 6-5 | Busch Stadium II (1-0) | 1-0 | |
| » W: Ken Dayley (1-0) L: Mark Gardner (0-1) | First | -- |
| » Major-league debuts: Howard Hilton (Cardinals) Delino DeShields (Expos) |
| Tuesday, April 10 |
| » Defeated Expos (0-2), 4-2 | Busch Stadium II (2-0) | 2-0 | Won 2 |
| » W: Bryn Smith (1-0) L: Zane Smith (0-1) S: Scott Terry (1) | First | -- |
| » Major-league debuts: Bill Sampen (Expos) |
| Wednesday, April 11 |
| » Lost to Expos (1-2), 6-4 | Busch Stadium II (2-1) | 2-1 | |
| » W: Oil Can Boyd (1-0) L: Greg Mathews (0-1) S: Tim Burke (1) | Second | 1 out |
| Friday, April 13 |
| » Defeated Phillies (1-3), 11-0 | Veteran's Stadium (1-0) | 3-1 | |
| » W: John Tudor (1-0) L: Ken Howell (0-1) S: Bob Tewksbury (1) | First | -- |
| Saturday, April 14 |
| » Lost to Phillies (2-3), 6-2 | Veteran's Stadium (1-1) | 3-2 | |
| » W: Bruce Ruffin (1-0) L: Joe Magrane (0-1) S: Jeff Parrett (1) | Second | 1 out |
| Sunday, April 15 |
| » Lost to Phillies (3-3), 4-0 | Veteran's Stadium (1-2) | 3-3 | Lost 2 |
| » W: Dennis Cook (1-0) L: Bryn Smith (1-1) S: Roger McDowell (2) | Second | 1 out |
| Monday, April 16 |
| » Defeated Pirates (3-4), 6-4 | Three Rivers Stadium (1-0) | 4-3 | |
| » W: Jose DeLeon (1-0) L: John Smiley (0-2) S: Ricky Horton (1) | First | -- |
| Tuesday, April 17 |
| » Lost to Pirates (4-4), 7-2 | Three Rivers Stadium (1-1) | 4-4 | |
| » W: Neal Heaton (2-0) L: Greg Mathews (0-2) | Second | 1 out |
| Wednesday, April 18 |
| » Defeated Pirates (4-5), 3-0 | Three Rivers Stadium (2-1) | 5-4 | |
| » W: John Tudor (2-0) L: Bob Walk (0-2) S: Ken Dayley (1) | Second | 1 out |
| Thursday, April 19 |
| » Lost to Pirates (5-5), 5-1 | Busch Stadium II (2-2) | 5-5 | |
| » W: Doug Drabek (2-1) L: Joe Magrane (0-2) | Second | 1 out |
| Friday, April 20 |
| » Lost to Phillies (5-6), 3-0 | Busch Stadium II (2-3) | 5-6 | Lost 2 |
| » W: Dennis Cook (2-0) L: Bryn Smith (1-2) | Third | 2 out |
| Saturday, April 21 |
| » Lost to Phillies (6-6), 7-6 | Busch Stadium II (2-4) | 5-7 | Lost 3 |
| » W: Roger McDowell (1-0) L: Scott Terry (0-1) | Third | 2 out |
| Former Cardinal Johnny Beazley dies in Nashville, TN at the age of 72. |
| Sunday, April 22 |
| » Lost to Phillies (7-6), 5-3 | Busch Stadium II (2-5) | 5-8 | Lost 4 |
| » W: Pat Combs (1-1) L: Ricky Horton (0-1) S: Roger McDowell (4) | Fourth | 3 out |
| Monday, April 23 |
| » Defeated Pirates (8-6), 7-4 | Busch Stadium II (3-5) | 6-8 | |
| » W: John Tudor (3-0) L: Bob Walk (0-3) | Fourth | 2 out |
| Tuesday, April 24 |
| » Lost to Dodgers (9-6), 3-0 | Dodger Stadium (0-1) | 6-9 | |
| » W: Mike Morgan (3-0) L: Joe Magrane (0-3) | Fifth | 3 out |
| » Major-league debuts: Brian Traxler (Dodgers) |
| Wednesday, April 25 |
| » Defeated Dodgers (9-7), 5-1 | Dodger Stadium (1-1) | 7-9 | |
| » W: Bryn Smith (2-2) L: Orel Hershiser (1-1) | Fourth | 3 out |
| Thursday, April 26 |
| » Defeated Dodgers (9-8), 7-1 | Dodger Stadium (2-1) | 8-9 | Won 2 |
| » W: Jose DeLeon (2-0) L: Tim Belcher (1-2) | Fourth | 3 out |
| Friday, April 27 |
| » Lost to Giants (6-11), 12-3 | Candlestick Park (0-1) | 8-10 | |
| » W: Atlee Hammaker (2-1) L: Greg Mathews (0-3) | Third | 4 out |
| Saturday, April 28 |
| » Defeated Giants (6-12), 5-0 | Candlestick Park (1-1) | 9-10 | |
| » W: John Tudor (4-0) L: Scott Garrelts (0-2) | Fourth | 4 out |
| Sunday, April 29 |
| » Lost to Giants (7-12), 9-7 | Candlestick Park (1-2) | 9-11 | |
| » W: Rick Reuschel (2-1) L: Joe Magrane (0-4) S: Steve Bedrosian (3) | Fourth | 5 out |
| Tuesday, May 1 |
| » Defeated Padres (9-11), 2-1 | San Diego/Jack Murphy Stadium (1-0) | 10-11 | |
| » W: Bryn Smith (3-2) L: Ed Whitson (2-1) S: Scott Terry (2) | Third | 4 out |
| Wednesday, May 2 |
| » Lost to Padres (10-11), 4-3 | San Diego/Jack Murphy Stadium (1-1) | 10-12 | |
| » W: Bruce Hurst (1-3) L: Jose DeLeon (2-1) S: Craig Lefferts (3) | Fifth | 4 out |
| Friday, May 4 |
| » Lost to Reds (15-5), 8-3 | Busch Stadium II (3-6) | 10-13 | Lost 2 |
| » W: Ron Robinson (1-1) L: John Tudor (4-1) S: Rob Dibble (4) | Sixth | 4½ out |
| Saturday, May 5 |
| » Lost to Reds (16-5), 4-2 | Busch Stadium II (3-7) | 10-14 | Lost 3 |
| » W: Jose Rijo (2-1) L: Joe Magrane (0-5) S: Randy Myers (6) | Sixth | 5 out |
| Sunday, May 6 |
| » Lost to Reds (17-5), 5-1 | Busch Stadium II (3-8) | 10-15 | Lost 4 |
| » W: Scott Scudder (1-0) L: Bryn Smith (3-3) S: Norm Charlton (1) | Sixth | 6½ out |
| Monday, May 7 |
| » Lost to Reds (18-5), 3-0 | Busch Stadium II (3-9) | 10-16 | Lost 5 |
| » W: Tom Browning (3-2) L: Jose DeLeon (2-2) | Sixth | 7½ out |
| Wednesday, May 9 |
| » Defeated Padres (12-15), 11-5 | Busch Stadium II (4-9) | 11-16 | |
| » W: Ricky Horton (1-1) L: Andy Benes (2-3) | Sixth | 8 out |
| Thursday, May 10 |
| » Lost to Padres (13-15), 9-1 | Busch Stadium II (4-10) | 11-17 | |
| » W: Dennis Rasmussen (3-1) L: Joe Magrane (0-6) | Sixth | 8 out |
| Friday, May 11 |
| » Defeated Braves (8-18), 5-2 | Busch Stadium II (5-10) | 12-17 | |
| » W: Bryn Smith (4-3) L: John Smoltz (1-4) S: Lee Smith (5) | Sixth | 8 out |
| Saturday, May 12 |
| » Defeated Braves (8-19), 4-3 | Busch Stadium II (6-10) | 13-17 | Won 2 |
| » W: Lee Smith (3-1) L: Joe Boever (0-2) | Sixth | 8 out |
| Sunday, May 13 |
| » Lost to Braves (9-19), 3-1 | Busch Stadium II (6-11) | 13-18 | |
| » W: Tony Castillo (1-0) L: Scott Terry (0-2) S: Joe Boever (4) | Sixth | 9 out |
| Tuesday, May 15 |
| » Defeated Astros (12-20), 4-0 | Busch Stadium II (7-11) | 14-18 | |
| » W: Joe Magrane (1-6) L: Mike Scott (1-4) | Sixth | 7½ out |
| Wednesday, May 16 |
| » Defeated Astros (12-21), 10-6 | Busch Stadium II (8-11) | 15-18 | Won 2 |
| » W: Bryn Smith (5-3) L: Jim Deshaies (1-2) | Fifth | 7 out |
| Thursday, May 17 |
| » Defeated Reds (23-8), 3-0 | Riverfront Stadium (1-0) | 16-18 | Won 3 |
| » W: Jose DeLeon (3-2) L: Tom Browning (3-4) S: Lee Smith (6) | Fifth | 6 out |
| Friday, May 18 |
| » Lost to Reds (24-8), 1-0 | Riverfront Stadium (1-1) | 16-19 | |
| » W: Norm Charlton (3-0) L: Ken Dayley (1-1) | Fifth | 7 out |
| Saturday, May 19 |
| » Lost to Reds (25-8), 4-0 | Riverfront Stadium (1-2) | 16-20 | Lost 2 |
| » W: Jack Armstrong (7-1) L: John Tudor (4-2) | Sixth | 7 out |
| Sunday, May 20 |
| » Defeated Reds (25-9), 6-2 | Riverfront Stadium (2-2) | 17-20 | |
| » W: Joe Magrane (2-6) L: Danny Jackson (0-1) | Sixth | 6 out |
| Monday, May 21 |
| » Lost to Braves (15-21), 6-5 | Atlanta-Fulton County Stadium (0-1) | 17-21 | |
| » W: Joe Boever (1-2) L: Scott Terry (0-3) | Sixth | 6 out |
| Tuesday, May 22 |
| » Defeated Braves (15-22), 4-3 | Atlanta-Fulton County Stadium (1-1) | 18-21 | |
| » W: Jose DeLeon (4-2) L: Derek Lilliquist (2-5) S: Lee Smith (7) | Sixth | 6 out |
| Wednesday, May 23 |
| » Lost to Giants (16-24), 6-1 | Busch Stadium II (8-12) | 18-22 | |
| » W: Bob Knepper (3-2) L: Greg Mathews (0-4) | Sixth | 6 out |
| Thursday, May 24 |
| » Defeated Giants (16-25), 3-2 | Busch Stadium II (9-12) | 19-22 | |
| » W: Frank DiPino (1-0) L: Ed Vosberg (0-1) | Fifth | 5½ out |
| Friday, May 25 |
| » Lost to Dodgers (22-20), 4-1 | Busch Stadium II (9-13) | 19-23 | |
| » W: Ramon Martinez (5-2) L: Joe Magrane (2-7) | Sixth | 6 out |
| Saturday, May 26 |
| » Lost to Dodgers (23-20), 8-0 | Busch Stadium II (9-14) | 19-24 | Lost 2 |
| » W: Mike Morgan (6-3) L: Bryn Smith (5-4) | Fifth | 6½ out |
| Sunday, May 27 |
| » Lost to Dodgers (24-20), 14-7 | Busch Stadium II (9-15) | 19-25 | Lost 3 |
| » W: Tim Crews (1-1) L: Jose DeLeon (4-3) | Sixth | 7½ out |
| Monday, May 28 |
| » Lost to Astros (18-26), 5-1 | Astrodome (0-1) | 19-26 | Lost 4 |
| » W: Bill Gullickson (3-3) L: Greg Mathews (0-5) S: Dave Smith (9) | Sixth | 8½ out |
| Tuesday, May 29 |
| » Defeated Astros (18-27), 3-2 | Astrodome (1-1) | 20-26 | |
| » W: John Tudor (5-2) L: Dan Schatzeder (1-3) S: Lee Smith (8) | Sixth | 8½ out |
| Wednesday, May 30 |
| » Lost to Astros (19-27), 2-1 | Astrodome (1-2) | 20-27 | |
| » W: Juan Agosto (4-1) L: Joe Magrane (2-8) S: Dave Smith (10) | Sixth | 9½ out |
| Friday, June 1 |
| » Defeated Cubs (21-27), 6-4 | Busch Stadium II (10-15) | 21-27 | |
| » W: Jose DeLeon (5-3) L: Greg Maddux (4-5) S: Lee Smith (9) | Fifth | 8½ out |
| » Major-league debuts: Hector Villanueva (Cubs) |
| Saturday, June 2 |
| » Lost to Cubs (22-27), 7-6 | Busch Stadium II (10-16) | 21-28 | |
| » W: Les Lancaster (4-2) L: Lee Smith (3-2) S: Mitch Williams (9) | Sixth | 9½ out |
| Sunday, June 3 |
| » Defeated Cubs (22-28), 7-4 | Busch Stadium II (11-16) | 22-28 | |
| » W: Bryn Smith (6-4) L: Kevin Blankenship (0-2) | Fifth | 8½ out |
| Monday, June 4 |
| » Defeated Phillies (26-22), 3-2 | Busch Stadium II (12-16) | 23-28 | Won 2 |
| » W: Frank DiPino (2-0) L: Marvin Freeman (0-1) | Fourth | 8½ out |
| Tuesday, June 5 |
| » Lost to Phillies (27-22), 9-6 | Busch Stadium II (12-17) | 23-29 | |
| » W: Don Carman (3-0) L: Scott Terry (0-4) | Fifth | 9½ out |
| Wednesday, June 6 |
| » Defeated Phillies (27-23), 12-11 | Busch Stadium II (13-17) | 24-29 | |
| » W: Frank DiPino (3-0) L: Roger McDowell (2-1) | Fifth | 9½ out |
| Thursday, June 7 |
| » Lost to Expos (29-24), 3-2 | Stade Olympique (0-1) | 24-30 | |
| » W: Zane Smith (3-3) L: Jose DeLeon (5-4) S: Dave Schmidt (3) | Fifth | 10½ out |
| Friday, June 8 |
| » Lost to Expos (30-24), 18-2 | Stade Olympique (0-2) | 24-31 | Lost 2 |
| » W: Dennis Martinez (4-4) L: Bryn Smith (6-5) | Fifth | 10½ out |
| Saturday, June 9 |
| » Lost to Expos (31-24), 3-1 | Stade Olympique (0-3) | 24-32 | Lost 3 |
| » W: Mark Gardner (3-2) L: Scott Terry (0-5) S: Dave Schmidt (4) | Fifth | 10½ out |
| Sunday, June 10 |
| » Defeated Expos (31-25), 5-3 | Stade Olympique (1-3) | 25-32 | |
| » W: Joe Magrane (3-8) L: Oil Can Boyd (3-3) S: Lee Smith (10) | Fifth | 9½ out |
| Monday, June 11 |
| » Lost to Pirates (35-22), 8-7 | Busch Stadium II (13-18) | 25-33 | |
| » W: Stan Belinda (2-1) L: Tom Niedenfuer (0-1) S: Bill Landrum (9) | Sixth | 10½ out |
| Tuesday, June 12 |
| » Lost to Pirates (36-22), 6-3 | Busch Stadium II (13-19) | 25-34 | Lost 2 |
| » W: Neal Heaton (9-1) L: Jose DeLeon (5-5) S: Bill Landrum (10) | Sixth | 11½ out |
| Wednesday, June 13 |
| » Lost to Pirates (37-22), 6-5 | Busch Stadium II (13-20) | 25-35 | Lost 3 |
| » W: Mark Huismann (1-0) L: Frank DiPino (3-1) S: Rick Reed (1) | Sixth | 12½ out |
| Thursday, June 14 |
| » Lost to Expos (35-26), 3-2 | Busch Stadium II (13-21) | 25-36 | Lost 4 |
| » W: Bill Sampen (5-0) L: Tom Niedenfuer (0-2) S: Dave Schmidt (6) | Sixth | 13 out |
| Friday, June 15 |
| » Lost to Expos (36-26), 7-4 | Busch Stadium II (13-22) | 25-37 | Lost 5 |
| » W: Steve Frey (3-1) L: Joe Magrane (3-9) S: Dave Schmidt (7) | Sixth | 13 out |
| Saturday, June 16 |
| » Defeated Expos (36-27), 5-3 | Busch Stadium II (14-22) | 26-37 | |
| » W: Bob Tewksbury (1-0) L: Drew Hall (4-7) S: Tom Niedenfuer (1) | Fifth | 13 out |
| Sunday, June 17 |
| » Defeated Expos (36-28), 7-1 | Busch Stadium II (15-22) | 27-37 | Won 2 |
| » W: Jose DeLeon (6-5) L: Zane Smith (3-5) | Fifth | 12 out |
| Tuesday, June 19 |
| » Lost to Mets (32-29), 6-0 | Shea Stadium (0-1) | 27-38 | |
| » W: David Cone (3-4) L: John Tudor (5-3) | Sixth | 12 out |
| Wednesday, June 20 |
| » Lost to Mets (33-29), 6-3 | Shea Stadium (0-2) | 27-39 | Lost 2 |
| » W: Sid Fernandez (5-5) L: Bryn Smith (6-6) S: John Franco (12) | Sixth | 12 out |
| Friday, June 22 |
| » Defeated Cubs (28-41), 7-0 | Wrigley Field (1-0) | 28-39 | |
| » W: Joe Magrane (4-9) L: Steve Wilson (1-5) | Fifth | 11 out |
| Saturday, June 23 |
| » Defeated Cubs (28-42), 8-7 | Wrigley Field (2-0) | 29-39 | Won 2 |
| » W: Bob Tewksbury (2-0) L: Mike Bielecki (3-7) S: Lee Smith (11) | Fifth | 10½ out |
| Sunday, June 24 |
| » Lost to Cubs (29-42), 3-2 | Wrigley Field (2-1) | 29-40 | |
| » W: Paul Assenmacher (2-1) L: Tom Niedenfuer (0-3) | Fifth | 11 out |
| Monday, June 25 |
| » Lost to Mets (37-29), 3-2 | Busch Stadium II (15-23) | 29-41 | Lost 2 |
| » W: David Cone (4-4) L: Lee Smith (3-3) S: John Franco (13) | Fifth | 12 out |
| Tuesday, June 26 |
| » Lost to Mets (38-29), 8-6 | Busch Stadium II (15-24) | 29-42 | Lost 3 |
| » W: Alejandro Pena (2-2) L: Ken Dayley (1-2) | Fifth | 13 out |
| Wednesday, June 27 |
| » Lost to Mets (39-29), 5-2 | Busch Stadium II (15-25) | 29-43 | Lost 4 |
| » W: Frank Viola (11-3) L: Joe Magrane (4-10) | Sixth | 14 out |
| Thursday, June 28 |
| » Defeated Pirates (42-29), 5-1 | Busch Stadium II (16-25) | 30-43 | |
| » W: Bob Tewksbury (3-0) L: Doug Drabek (8-4) S: Lee Smith (12) | Sixth | 13 out |
| Friday, June 29 |
| » Lost to Dodgers (36-37), 6-0 | Dodger Stadium (2-2) | 30-44 | |
| » W: Fernando Valenzuela (6-6) L: Jose DeLeon (6-6) | Sixth | 13 out |
| Saturday, June 30 |
| » Defeated Dodgers (36-38), 6-5 | Dodger Stadium (3-2) | 31-44 | |
| » W: John Tudor (6-3) L: Jim Gott (0-2) S: Lee Smith (13) | Sixth | 13 out |
| Sunday, July 1 |
| » Defeated Dodgers (36-39), 6-5 | Dodger Stadium (4-2) | 32-44 | Won 2 |
| » W: Frank DiPino (4-1) L: Tim Crews (1-3) S: Lee Smith (14) | Sixth | 13 out |
| Monday, July 2 |
| » Lost to Giants (39-38), 3-2 | Candlestick Park (1-3) | 32-45 | |
| » W: Don Robinson (4-1) L: Joe Magrane (4-11) S: Jeff Brantley (11) | Sixth | 14 out |
| Tuesday, July 3 |
| » Lost to Giants (40-38), 4-0 | Candlestick Park (1-4) | 32-46 | Lost 2 |
| » W: Trevor Wilson (5-0) L: Bob Tewksbury (3-1) | Sixth | 15 out |
| Wednesday, July 4 |
| » Lost to Giants (41-38), 9-2 | Candlestick Park (1-5) | 32-47 | Lost 3 |
| » W: John Burkett (8-2) L: Jose DeLeon (6-7) S: Jeff Brantley (12) | Sixth | 15 out |
| Thursday, July 5 |
| » Defeated Padres (36-41), 4-1 | San Diego/Jack Murphy Stadium (2-1) | 33-47 | |
| » W: Lee Smith (4-3) L: Greg Harris (4-3) | Sixth | 15 out |
| Friday, July 6 |
| » Defeated Padres (36-42), 5-3 | San Diego/Jack Murphy Stadium (3-1) | 34-47 | Won 2 |
| » Manager: Red Schoendienst |
| » W: John Tudor (7-3) L: Dennis Rasmussen (7-5) S: Lee Smith (15) | Sixth | 15 out |
| Saturday, July 7 |
| » Lost to Padres (37-42), 3-1 | San Diego/Jack Murphy Stadium (3-2) | 34-48 | |
| » W: Bruce Hurst (5-7) L: Joe Magrane (4-12) | Sixth | 15 out |
| Sunday, July 8 |
| » Defeated Padres (37-43), 4-1 | San Diego/Jack Murphy Stadium (4-2) | 35-48 | |
| » W: Bob Tewksbury (4-1) L: Ed Whitson (6-6) | Sixth | 15 out |
| Thursday, July 12 |
| » Lost to Giants (45-39), 4-2 | Busch Stadium II (16-26) | 35-49 | |
| » W: Scott Garrelts (6-7) L: Bryn Smith (6-7) | Sixth | 16 out |
| Friday, July 13 |
| » Lost to Giants (46-39), 6-1 | Busch Stadium II (16-27) | 35-50 | Lost 2 |
| » W: Don Robinson (5-1) L: Jose DeLeon (6-8) S: Jeff Brantley (14) | Sixth | 17 out |
| Saturday, July 14 |
| » Defeated Giants (46-40), 2-1 | Busch Stadium II (17-27) | 36-50 | |
| » W: Lee Smith (5-3) L: Trevor Wilson (6-1) | Fifth | 17 out |
| Sunday, July 15 |
| » Lost to Giants (47-40), 5-3 | Busch Stadium II (17-28) | 36-51 | |
| » W: Steve Bedrosian (4-5) L: Tom Niedenfuer (0-4) S: Jeff Brantley (15) | Sixth | 17 out |
| Monday, July 16 |
| » Lost to Dodgers (43-44), 5-2 | Busch Stadium II (17-29) | 36-52 | Lost 2 |
| » W: Terry Wells (1-1) L: Bob Tewksbury (4-2) S: Jay Howell (7) | Sixth | 17 out |
| Tuesday, July 17 |
| » Defeated Dodgers (43-45), 3-0 | Busch Stadium II (18-29) | 37-52 | |
| » W: Bryn Smith (7-7) L: Fernando Valenzuela (7-8) S: Lee Smith (16) | Sixth | 16 out |
| Wednesday, July 18 |
| » Lost to Dodgers (44-45), 6-1 | Busch Stadium II (18-30) | 37-53 | |
| » W: Ramon Martinez (11-4) L: Jose DeLeon (6-9) S: Jay Howell (8) | Sixth | 17 out |
| Thursday, July 19 |
| » Defeated Padres (38-50), 8-3 | Busch Stadium II (19-30) | 38-53 | |
| » W: Joe Magrane (5-12) L: Bruce Hurst (5-8) S: Frank DiPino (1) | Sixth | 16½ out |
| Friday, July 20 |
| » Defeated Padres (38-51), 4-2 | Busch Stadium II (20-30) | 39-53 | Won 2 |
| » W: John Tudor (8-3) L: Ed Whitson (7-7) S: Lee Smith (17) | Sixth | 16½ out |
| Saturday, July 21 |
| » Defeated Padres (38-52), 4-2 | Busch Stadium II (21-30) | 40-53 | Won 3 |
| » W: Bob Tewksbury (5-2) L: Eric Show (1-8) S: Frank DiPino (2) | Sixth | 15½ out |
| Sunday, July 22 |
| » Defeated Padres (38-53), 6-4 | Busch Stadium II (22-30) | 41-53 | Won 4 |
| » W: Ken Dayley (2-2) L: Greg Harris (4-5) S: Lee Smith (18) | Sixth | 15½ out |
| Monday, July 23 |
| » Lost to Cubs (44-52), 3-1 | Busch Stadium II (22-31) | 41-54 | |
| » W: Greg Maddux (6-9) L: Jose DeLeon (6-10) S: Mitch Williams (11) | Sixth | 15½ out |
| Tuesday, July 24 |
| » Defeated Cubs (44-53), 9-4 | Busch Stadium II (23-31) | 42-54 | |
| » W: Scott Terry (1-5) L: Steve Wilson (3-6) | Sixth | 15½ out |
| Wednesday, July 25 |
| » Defeated Cubs (44-54), 9-0 | Busch Stadium II (24-31) | 43-54 | Won 2 |
| » W: John Tudor (9-3) L: Mike Harkey (8-5) | Sixth | 14½ out |
| Thursday, July 26 |
| » Lost to Mets (56-38), 6-1 | Shea Stadium (0-3) | 43-55 | |
| » W: Ron Darling (4-5) L: Bob Tewksbury (5-3) | Fourth | 14 out |
| » Defeated Mets (56-39), 3-1 | Shea Stadium (1-3) | 44-55 | |
| » W: Ken Hill (1-0) L: Bob Ojeda (4-5) S: Lee Smith (19) | Fourth | 14 out |
| Friday, July 27 |
| » Lost to Mets (57-39), 10-1 | Shea Stadium (1-4) | 44-56 | |
| » W: Frank Viola (14-5) L: Bryn Smith (7-8) | Sixth | 15 out |
| Saturday, July 28 |
| » Defeated Mets (57-40), 1-0 | Shea Stadium (2-4) | 45-56 | |
| » W: Joe Magrane (6-12) L: David Cone (7-5) S: Lee Smith (20) | Sixth | 14 out |
| Former Cardinal Red Barrett dies in Wilson, NC at the age of 76. |
| Sunday, July 29 |
| » Lost to Mets (58-40), 6-0 | Shea Stadium (2-5) | 45-57 | |
| » W: Dwight Gooden (11-5) L: Jose DeLeon (6-11) | Sixth | 15 out |
| Tuesday, July 31 |
| » Defeated Phillies (49-50), 4-2 | Veteran's Stadium (2-2) | 46-57 | |
| » W: John Tudor (10-3) L: Ken Howell (8-7) S: Lee Smith (21) | Fifth | 14 out |
| Wednesday, August 1 |
| » Lost to Phillies (50-50), 11-10 | Veteran's Stadium (2-3) | 46-58 | |
| » W: Terry Mulholland (6-4) L: Ken Hill (1-1) S: Roger McDowell (16) | Sixth | 15 out |
| Thursday, August 2 |
| » Defeated Phillies (50-51), 4-3 | Veteran's Stadium (3-3) | 47-58 | |
| » Manager: Joe Torre |
| » W: Bob Tewksbury (6-3) L: Jose DeJesus (2-3) S: Lee Smith (22) | Sixth | 15 out |
| Friday, August 3 |
| » Lost to Mets (61-41), 5-4 | Busch Stadium II (24-32) | 47-59 | |
| » W: Julio Machado (4-1) L: Lee Smith (5-4) S: John Franco (24) | Sixth | 16 out |
| Saturday, August 4 |
| » Defeated Mets (61-42), 7-5 | Busch Stadium II (25-32) | 48-59 | |
| » W: Ken Hill (2-1) L: Dwight Gooden (11-6) S: Frank DiPino (3) | Fifth | 15 out |
| Sunday, August 5 |
| » Defeated Mets (61-43), 8-3 | Busch Stadium II (26-32) | 49-59 | Won 2 |
| » W: John Tudor (11-3) L: Sid Fernandez (7-8) | Fifth | 14 out |
| Monday, August 6 |
| » Defeated Mets (61-44), 5-1 | Busch Stadium II (27-32) | 50-59 | Won 3 |
| » W: Joe Magrane (7-12) L: Ron Darling (4-6) S: Lee Smith (23) | Sixth | 14½ out |
| Tuesday, August 7 |
| » Lost to Cubs (52-57), 5-3 | Wrigley Field (2-2) | 50-60 | |
| » W: Paul Assenmacher (4-2) L: Scott Terry (1-6) S: Mitch Williams (13) | Sixth | 15½ out |
| Wednesday, August 8 |
| » Lost to Cubs (53-57), 4-3 | Wrigley Field (2-3) | 50-61 | Lost 2 |
| » W: Bill Long (5-1) L: Tom Niedenfuer (0-5) | Sixth | 15½ out |
| Thursday, August 9 |
| » Defeated Cubs (53-58), 3-1 | Wrigley Field (3-3) | 51-61 | |
| » W: Ken Hill (3-1) L: Lance Dickson (0-1) S: Lee Smith (24) | Sixth | 14½ out |
| » Major-league debuts: Lance Dickson (Cubs) |
| Friday, August 10 |
| » Defeated Pirates (64-46), 8-3 | Three Rivers Stadium (3-1) | 52-61 | Won 2 |
| » W: Ken Dayley (3-2) L: Randy Kramer (0-1) | Sixth | 14 out |
| Saturday, August 11 |
| » Defeated Pirates (64-47), 3-2 | Three Rivers Stadium (4-1) | 53-61 | Won 3 |
| » W: Joe Magrane (8-12) L: Randy Tomlin (1-1) S: Lee Smith (25) | Sixth | 13 out |
| Sunday, August 12 |
| » Defeated Pirates (64-48), 6-0 | Three Rivers Stadium (5-1) | 54-61 | Won 4 |
| » W: Bob Tewksbury (7-3) L: John Smiley (5-6) | Fifth | 12 out |
| Monday, August 13 |
| » Major-league debuts: Dave Walsh (Dodgers) |
| Tuesday, August 14 |
| » Lost to Reds (67-47), 9-4 | Busch Stadium II (27-33) | 54-62 | |
| » W: Jack Armstrong (12-8) L: Jose DeLeon (6-12) S: Rick Mahler (3) | Sixth | 13 out |
| » Major-league debuts: Tim Sherrill (Cardinals) |
| Wednesday, August 15 |
| » Lost to Reds (68-47), 3-1 | Busch Stadium II (27-34) | 54-63 | Lost 2 |
| » W: Rob Dibble (5-3) L: Tom Niedenfuer (0-6) S: Tim Layana (2) | Sixth | 13 out |
| Thursday, August 16 |
| » Lost to Astros (52-66), 4-2 | Busch Stadium II (27-35) | 54-64 | Lost 3 |
| » W: Danny Darwin (8-1) L: Joe Magrane (8-13) S: Dave Smith (20) | Sixth | 14 out |
| Friday, August 17 |
| » Defeated Astros (52-67), 5-0 | Busch Stadium II (28-35) | 55-64 | |
| » W: Bob Tewksbury (8-3) L: Bill Gullickson (8-10) | Sixth | 14½ out |
| Saturday, August 18 |
| » Lost to Astros (53-67), 3-2 | Busch Stadium II (28-36) | 55-65 | |
| » W: Dave Smith (4-4) L: Frank DiPino (4-2) | Sixth | 15½ out |
| » Major-league debuts: Omar Olivares (Cardinals) |
| Sunday, August 19 |
| » Defeated Astros (53-68), 7-3 | Busch Stadium II (29-36) | 56-65 | |
| » W: Jose DeLeon (7-12) L: Mike Scott (9-12) | Sixth | 15½ out |
| Monday, August 20 |
| » Defeated Braves (45-76), 7-2 | Busch Stadium II (30-36) | 57-65 | Won 2 |
| » W: Ken Hill (4-1) L: Tom Glavine (6-10) | Sixth | 15½ out |
| Tuesday, August 21 |
| » Lost to Braves (46-76), 7-2 | Busch Stadium II (30-37) | 57-66 | |
| » W: John Smoltz (10-9) L: Joe Magrane (8-14) | Sixth | 15½ out |
| » Major-league debuts: Ray Lankford (Cardinals) |
| Wednesday, August 22 |
| » Lost to Braves (47-76), 2-1 | Busch Stadium II (30-38) | 57-67 | Lost 2 |
| » W: Tony Castillo (4-1) L: Bob Tewksbury (8-4) S: Kent Mercker (3) | Sixth | 16½ out |
| Friday, August 24 |
| » Defeated Astros (55-71), 3-2 | Astrodome (2-2) | 58-67 | |
| » W: Scott Terry (2-6) L: Dave Smith (4-5) S: Lee Smith (26) | Sixth | 16 out |
| Saturday, August 25 |
| » Lost to Astros (56-71), 6-4 | Astrodome (2-3) | 58-68 | |
| » W: Jim Deshaies (6-11) L: Jose DeLeon (7-13) S: Juan Agosto (2) | Sixth | 16 out |
| Sunday, August 26 |
| » Lost to Astros (57-71), 4-2 | Astrodome (2-4) | 58-69 | Lost 2 |
| » W: Danny Darwin (10-1) L: Ken Hill (4-2) | Sixth | 16 out |
| Tuesday, August 28 |
| » Lost to Reds (74-53), 2-1 | Riverfront Stadium (2-3) | 58-70 | Lost 3 |
| » W: Jose Rijo (10-6) L: Joe Magrane (8-15) S: Randy Myers (26) | Sixth | 16 out |
| Former Cardinal Larry Jackson dies in Boise, ID at the age of 60. |
| Wednesday, August 29 |
| » Defeated Reds (74-54), 9-1 | Riverfront Stadium (3-3) | 59-70 | |
| » W: Bob Tewksbury (9-4) L: Tom Browning (12-7) | Sixth | 16 out |
| Thursday, August 30 |
| » Defeated Braves (50-80), 5-3 | Atlanta-Fulton County Stadium (2-1) | 60-70 | Won 2 |
| » W: Frank DiPino (5-2) L: Dwayne Henry (2-2) S: Tom Niedenfuer (2) | Fifth | 15½ out |
| Friday, August 31 |
| » Lost to Braves (51-80), 4-1 | Atlanta-Fulton County Stadium (2-2) | 60-71 | |
| » W: John Smoltz (12-9) L: Jose DeLeon (7-14) S: Kent Mercker (4) | Sixth | 15½ out |
| Saturday, September 1 |
| » Lost to Braves (52-80), 4-3 | Atlanta-Fulton County Stadium (2-3) | 60-72 | Lost 2 |
| » W: Tony Castillo (5-1) L: Ken Hill (4-3) S: Kent Mercker (5) | Fifth | 16 out |
| » Major-league debuts: Paul Marak (Braves) |
| Former Cardinal Buster Adams dies in Rancho Mirage, CA at the age of 76. |
| Sunday, September 2 |
| » Lost to Braves (53-80), 5-0 | Atlanta-Fulton County Stadium (2-4) | 60-73 | Lost 3 |
| » W: Charlie Leibrandt (7-8) L: John Tudor (11-4) | Fifth | 17 out |
| Monday, September 3 |
| » Lost to Mets (77-55), 9-3 | Busch Stadium II (30-39) | 60-74 | Lost 4 |
| » W: Dwight Gooden (15-6) L: Bob Tewksbury (9-5) | Fifth | 18 out |
| » Major-league debuts: Kevin Baez (Mets) |
| Former Cardinal Marshall Bridges dies in Jackson, MS at the age of 60. |
| Tuesday, September 4 |
| » Defeated Mets (77-56), 1-0 | Busch Stadium II (31-39) | 61-74 | |
| » W: Joe Magrane (9-15) L: Sid Fernandez (9-11) S: Lee Smith (27) | Sixth | 17½ out |
| » Major-league debuts: Bernard Gilkey (Cardinals) |
| Wednesday, September 5 |
| » Lost to Expos (71-64), 6-2 | Busch Stadium II (31-40) | 61-75 | |
| » W: Chris Nabholz (4-0) L: Jose DeLeon (7-15) S: Tim Burke (16) | Fifth | 19 out |
| » Major-league debuts: Rod Brewer, Geronimo Pena and Mike Perez (Cardinals) |
| Thursday, September 6 |
| » Defeated Expos (71-65), 4-2 | Busch Stadium II (32-40) | 62-75 | |
| » W: Ken Dayley (4-2) L: Mark Gardner (7-9) S: Lee Smith (28) | Sixth | 19 out |
| Friday, September 7 |
| » Defeated Cubs (64-73), 4-3 | Wrigley Field (4-3) | 63-75 | Won 2 |
| » W: Bob Tewksbury (10-5) L: Greg Maddux (12-13) S: Lee Smith (29) | Fifth | 18 out |
| Saturday, September 8 |
| » Lost to Cubs (65-73), 5-4 | Wrigley Field (4-4) | 63-76 | |
| » W: Dave Pavlas (1-0) L: Ken Dayley (4-3) S: Paul Assenmacher (8) | Sixth | 19 out |
| Sunday, September 9 |
| » Defeated Cubs (65-74), 9-2 | Wrigley Field (5-4) | 64-76 | |
| » W: John Tudor (12-4) L: Mike Bielecki (7-10) | Fifth | 18 out |
| Monday, September 10 |
| » Lost to Mets (79-61), 10-1 | Shea Stadium (2-6) | 64-77 | |
| » W: Frank Viola (18-9) L: Jose DeLeon (7-16) | Fifth | 19 out |
| Tuesday, September 11 |
| » Lost to Mets (80-61), 10-8 | Shea Stadium (2-7) | 64-78 | Lost 2 |
| » W: John Franco (5-1) L: Lee Smith (5-5) | Sixth | 20 out |
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