| Monday, April 9 |
| » Lost to Reds (1-0), 8-4 | Astrodome (0-1) | 0-1 | |
| » W: Randy Myers (1-0) L: Charlie Kerfeld (0-1) | Third | 1 out |
| » Major-league debuts: Dave Rohde (Astros) Tim Layana (Reds) |
| Tuesday, April 10 |
| » Lost to Reds (2-0), 3-2 | Astrodome (0-2) | 0-2 | Lost 2 |
| » W: Tim Layana (1-0) L: Juan Agosto (0-1) S: Randy Myers (1) | Third | 2 out |
| Wednesday, April 11 |
| » Lost to Reds (3-0), 5-0 | Astrodome (0-3) | 0-3 | Lost 3 |
| » W: Jack Armstrong (1-0) L: Mark Portugal (0-1) S: Rick Mahler (1) | Fifth | 3 out |
| Friday, April 13 |
| » Lost to Dodgers (3-2), 6-1 | Astrodome (0-4) | 0-4 | Lost 4 |
| » W: Mike Morgan (1-0) L: Bill Gullickson (0-1) | Fifth | 4 out |
| Saturday, April 14 |
| » Defeated Dodgers (3-3), 7-3 | Astrodome (1-4) | 1-4 | |
| » W: Larry Andersen (1-0) L: John Wetteland (1-1) S: Dave Smith (1) | Sixth | 3½ out |
| Sunday, April 15 |
| » Lost to Dodgers (4-3), 5-4 | Astrodome (1-5) | 1-5 | |
| » W: Jay Howell (1-0) L: Charlie Kerfeld (0-2) | Sixth | 4½ out |
| Tuesday, April 17 |
| » Defeated Braves (1-6), 5-3 | Astrodome (2-5) | 2-5 | |
| » W: Mark Portugal (1-1) L: John Smoltz (0-2) S: Dave Smith (2) | Fifth | 5 out |
| Wednesday, April 18 |
| » Defeated Braves (1-7), 10-5 | Astrodome (3-5) | 3-5 | Won 2 |
| » W: Dan Schatzeder (1-0) L: Derek Lilliquist (0-2) | Fourth | 5 out |
| Thursday, April 19 |
| » Lost to Dodgers (7-4), 7-3 | Dodger Stadium (0-1) | 3-6 | |
| » W: Orel Hershiser (1-0) L: Mike Scott (0-1) | Fourth | 5½ out |
| Friday, April 20 |
| » Defeated Dodgers (7-5), 4-2 | Dodger Stadium (1-1) | 4-6 | |
| » W: Jim Deshaies (1-0) L: Tim Belcher (1-1) S: Dave Smith (3) | Fourth | 5 out |
| » Major-league debuts: Carlos Hernandez (Dodgers) |
| Saturday, April 21 |
| » Defeated Dodgers (7-6), 6-5 | Dodger Stadium (2-1) | 5-6 | Won 2 |
| » W: Juan Agosto (1-1) L: Jay Howell (1-1) S: Dave Smith (4) | Fourth | 5 out |
| Sunday, April 22 |
| » Lost to Dodgers (8-6), 2-0 | Dodger Stadium (2-2) | 5-7 | |
| » W: Ramon Martinez (1-0) L: Mark Portugal (1-2) | Fourth | 5 out |
| Tuesday, April 24 |
| » Lost to Expos (8-6), 5-3 | Astrodome (3-6) | 5-8 | Lost 2 |
| » W: Kevin Gross (1-1) L: Mike Scott (0-2) S: Tim Burke (4) | Fourth | 5 out |
| Wednesday, April 25 |
| » Lost to Expos (9-6), 1-0 | Astrodome (3-7) | 5-9 | Lost 3 |
| » W: Steve Frey (1-0) L: Dave Smith (0-1) S: Tim Burke (5) | Fourth | 6 out |
| Thursday, April 26 |
| » Defeated Braves (2-11), 3-0 | Atlanta-Fulton County Stadium (1-0) | 6-9 | |
| » W: Jim Clancy (1-0) L: Derek Lilliquist (0-3) S: Dave Smith (5) | Fourth | 5½ out |
| Friday, April 27 |
| » Lost to Mets (9-7), 1-0 | Astrodome (3-8) | 6-10 | |
| » W: Frank Viola (4-0) L: Mark Portugal (1-3) S: John Franco (6) | Fourth | 6½ out |
| Saturday, April 28 |
| » Defeated Mets (9-8), 8-4 | Astrodome (4-8) | 7-10 | |
| » W: Bill Gullickson (1-1) L: Sid Fernandez (1-2) S: Dave Smith (6) | Fourth | 6½ out |
| » Major-league debuts: Chuck Carr (Mets) |
| Sunday, April 29 |
| » Defeated Mets (9-9), 2-1 | Astrodome (5-8) | 8-10 | Won 2 |
| » W: Danny Darwin (1-0) L: Julio Machado (2-1) | Fourth | 5½ out |
| Monday, April 30 |
| » Defeated Expos (10-9), 4-2 | Stade Olympique (1-0) | 9-10 | Won 3 |
| » W: Larry Andersen (2-0) L: Dennis Martinez (2-1) S: Dave Smith (7) | Third | 5½ out |
| Tuesday, May 1 |
| » Lost to Expos (11-9), 2-1 | Stade Olympique (1-1) | 9-11 | |
| » W: Drew Hall (2-2) L: Larry Andersen (2-1) | Third | 5½ out |
| Wednesday, May 2 |
| » Lost to Phillies (12-9), 14-4 | Veteran's Stadium (0-1) | 9-12 | Lost 2 |
| » W: Dennis Cook (4-0) L: Jim Clancy (1-1) | Fourth | 5½ out |
| Thursday, May 3 |
| » Defeated Phillies (12-10), 10-3 | Veteran's Stadium (1-1) | 10-12 | |
| » W: Bill Gullickson (2-1) L: Terry Mulholland (1-1) S: Dave Smith (8) | Fourth | 5½ out |
| Saturday, May 5 |
| » Defeated Mets (10-13), 9-5 | Shea Stadium (1-0) | 11-12 | Won 2 |
| » W: Mike Scott (1-2) L: Dwight Gooden (1-3) S: Larry Andersen (1) | Third | 6 out |
| Sunday, May 6 |
| » Lost to Mets (11-13), 7-4 | Shea Stadium (1-1) | 11-13 | |
| » W: John Franco (1-0) L: Dave Smith (0-2) | Fourth | 7½ out |
| » Lost to Mets (12-13), 7-6 | Shea Stadium (1-2) | 11-14 | Lost 2 |
| » W: Alejandro Pena (1-0) L: Dan Schatzeder (1-1) | Fourth | 7½ out |
| Monday, May 7 |
| » Lost to Mets (13-13), 7-1 | Shea Stadium (1-3) | 11-15 | Lost 3 |
| » W: Frank Viola (6-0) L: Jim Clancy (1-2) S: Wally Whitehurst (1) | Fourth | 8½ out |
| Tuesday, May 8 |
| » Defeated Phillies (14-12), 3-2 | Astrodome (6-8) | 12-15 | |
| » W: Dave Smith (1-2) L: Dickie Noles (0-1) | Fourth | 8 out |
| Wednesday, May 9 |
| » Lost to Phillies (15-12), 10-1 | Astrodome (6-9) | 12-16 | |
| » W: Pat Combs (2-2) L: Mike Scott (1-3) | Fourth | 8 out |
| Friday, May 11 |
| » Lost to Pirates (20-9), 4-3 | Three Rivers Stadium (0-1) | 12-17 | Lost 2 |
| » W: Doug Drabek (6-1) L: Jim Deshaies (1-1) S: Bill Landrum (5) | Fourth | 9½ out |
| Saturday, May 12 |
| » Lost to Pirates (21-9), 3-1 | Three Rivers Stadium (0-2) | 12-18 | Lost 3 |
| » W: Neal Heaton (6-0) L: Mark Portugal (1-4) S: Ted Power (3) | Fourth | 9½ out |
| Sunday, May 13 |
| » Lost to Pirates (22-9), 5-1 | Three Rivers Stadium (0-3) | 12-19 | Lost 4 |
| » W: Bob Walk (3-3) L: Bill Gullickson (2-2) S: Bill Landrum (6) | Fourth | 10½ out |
| Tuesday, May 15 |
| » Lost to Cardinals (14-18), 4-0 | Busch Stadium II (0-1) | 12-20 | Lost 5 |
| » W: Joe Magrane (1-6) L: Mike Scott (1-4) | Fourth | 12 out |
| Wednesday, May 16 |
| » Lost to Cardinals (15-18), 10-6 | Busch Stadium II (0-2) | 12-21 | Lost 6 |
| » W: Bryn Smith (5-3) L: Jim Deshaies (1-2) | Fifth | 12½ out |
| Thursday, May 17 |
| » Defeated Cubs (15-19), 5-4 | Astrodome (7-9) | 13-21 | |
| » W: Dave Smith (2-2) L: Jose Nunez (1-4) | Fifth | 11½ out |
| Friday, May 18 |
| » Lost to Cubs (16-19), 7-0 | Astrodome (7-10) | 13-22 | |
| » W: Mike Harkey (4-1) L: Bill Gullickson (2-3) | Fifth | 12½ out |
| Saturday, May 19 |
| » Lost to Cubs (17-19), 4-1 | Astrodome (7-11) | 13-23 | Lost 2 |
| » W: Les Lancaster (3-1) L: Jim Clancy (1-3) S: Mitch Williams (8) | Sixth | 13½ out |
| Sunday, May 20 |
| » Lost to Cubs (18-19), 5-1 | Astrodome (7-12) | 13-24 | Lost 3 |
| » W: Shawn Boskie (1-0) L: Mike Scott (1-5) | Sixth | 13½ out |
| » Major-league debuts: Shawn Boskie (Cubs) |
| Monday, May 21 |
| » Defeated Pirates (23-15), 3-2 | Astrodome (8-12) | 14-24 | |
| » W: Juan Agosto (2-1) L: Ted Power (0-2) | Sixth | 13½ out |
| Tuesday, May 22 |
| » Lost to Pirates (24-15), 8-4 | Astrodome (8-13) | 14-25 | |
| » W: Neal Heaton (7-1) L: Dan Schatzeder (1-2) | Sixth | 13½ out |
| » Major-league debuts: Jeff Baldwin (Astros) |
| Wednesday, May 23 |
| » Defeated Pirates (24-16), 7-3 | Astrodome (9-13) | 15-25 | |
| » W: Juan Agosto (3-1) L: Scott Ruskin (0-1) | Sixth | 13 out |
| Saturday, May 26 |
| » Defeated Cubs (19-23), 8-1 | Wrigley Field (1-0) | 16-25 | Won 2 |
| » W: Mike Scott (2-5) L: Shawn Boskie (1-1) | Fourth | 13½ out |
| » Defeated Cubs (19-24), 12-3 | Wrigley Field (2-0) | 17-25 | Won 3 |
| » W: Jim Deshaies (2-2) L: Greg Maddux (4-4) S: Larry Andersen (2) | Fourth | 13½ out |
| Sunday, May 27 |
| » Lost to Cubs (20-24), 11-6 | Wrigley Field (2-1) | 17-26 | |
| » W: Mike Bielecki (3-3) L: Mark Portugal (1-5) | Fifth | 13½ out |
| Monday, May 28 |
| » Defeated Cardinals (19-26), 5-1 | Astrodome (10-13) | 18-26 | |
| » W: Bill Gullickson (3-3) L: Greg Mathews (0-5) S: Dave Smith (9) | Fourth | 13 out |
| Tuesday, May 29 |
| » Lost to Cardinals (20-26), 3-2 | Astrodome (10-14) | 18-27 | |
| » W: John Tudor (5-2) L: Dan Schatzeder (1-3) S: Lee Smith (8) | Fifth | 14 out |
| Wednesday, May 30 |
| » Defeated Cardinals (20-27), 2-1 | Astrodome (11-14) | 19-27 | |
| » W: Juan Agosto (4-1) L: Joe Magrane (2-8) S: Dave Smith (10) | Fourth | 13½ out |
| Thursday, May 31 |
| » Defeated Giants (19-29), 5-3 | Candlestick Park (1-0) | 20-27 | Won 2 |
| » W: Jim Deshaies (3-2) L: Scott Garrelts (1-6) S: Danny Darwin (1) | Fourth | 12½ out |
| Friday, June 1 |
| » Lost to Giants (20-29), 6-5 | Candlestick Park (1-1) | 20-28 | |
| » W: Steve Bedrosian (1-3) L: Jim Clancy (1-4) | Fourth | 13½ out |
| Saturday, June 2 |
| » Lost to Giants (21-29), 5-4 | Candlestick Park (1-2) | 20-29 | Lost 2 |
| » W: Steve Bedrosian (2-3) L: Danny Darwin (1-1) | Fifth | 14½ out |
| Sunday, June 3 |
| » Lost to Giants (22-29), 7-3 | Candlestick Park (1-3) | 20-30 | Lost 3 |
| » W: Atlee Hammaker (4-3) L: Mike Scott (2-6) S: Jeff Brantley (6) | Sixth | 15½ out |
| Monday, June 4 |
| » Lost to Padres (26-24), 10-2 | San Diego/Jack Murphy Stadium (0-1) | 20-31 | Lost 4 |
| » W: Andy Benes (6-4) L: Jim Clancy (1-5) S: Craig Lefferts (9) | Sixth | 15½ out |
| Tuesday, June 5 |
| » Lost to Padres (27-24), 11-2 | San Diego/Jack Murphy Stadium (0-2) | 20-32 | Lost 5 |
| » W: Dennis Rasmussen (6-2) L: Jim Deshaies (3-3) | Sixth | 15½ out |
| Wednesday, June 6 |
| » Lost to Padres (28-24), 3-2 | San Diego/Jack Murphy Stadium (0-3) | 20-33 | Lost 6 |
| » W: Craig Lefferts (3-1) L: Mark Portugal (1-6) | Sixth | 15½ out |
| Thursday, June 7 |
| » Lost to Reds (34-15), 6-1 | Astrodome (11-15) | 20-34 | Lost 7 |
| » W: Jose Rijo (4-1) L: Bill Gullickson (3-4) | Sixth | 16½ out |
| Friday, June 8 |
| » Defeated Reds (34-16), 3-1 | Astrodome (12-15) | 21-34 | |
| » W: Mike Scott (3-6) L: Randy Myers (1-1) | Sixth | 15½ out |
| Saturday, June 9 |
| » Defeated Reds (34-17), 4-1 | Astrodome (13-15) | 22-34 | Won 2 |
| » W: Jim Clancy (2-5) L: Rick Mahler (1-1) S: Dave Smith (11) | Sixth | 14½ out |
| Sunday, June 10 |
| » Defeated Reds (34-18), 4-2 | Astrodome (14-15) | 23-34 | Won 3 |
| » W: Danny Darwin (2-1) L: Jack Armstrong (8-3) | Fifth | 13½ out |
| Monday, June 11 |
| » Defeated Dodgers (28-30), 5-3 | Astrodome (15-15) | 24-34 | Won 4 |
| » W: Larry Andersen (3-1) L: Mike Morgan (6-5) S: Dave Smith (12) | Fourth | 13 out |
| Tuesday, June 12 |
| » Defeated Dodgers (28-31), 5-4 | Astrodome (16-15) | 25-34 | Won 5 |
| » W: Bill Gullickson (4-4) L: Mike Maddux (0-1) S: Dave Smith (13) | Fifth | 11½ out |
| Wednesday, June 13 |
| » Defeated Dodgers (28-32), 5-1 | Astrodome (17-15) | 26-34 | Won 6 |
| » W: Mike Scott (4-6) L: Tim Belcher (4-4) S: Danny Darwin (2) | Fifth | 11½ out |
| Friday, June 15 |
| » Lost to Reds (37-20), 6-3 | Riverfront Stadium (0-1) | 26-35 | |
| » W: Jack Armstrong (9-3) L: Jim Clancy (2-6) S: Randy Myers (12) | Fifth | 13 out |
| » Major-league debuts: Javier Ortiz (Astros) |
| Saturday, June 16 |
| » Lost to Reds (38-20), 6-2 | Riverfront Stadium (0-2) | 26-36 | Lost 2 |
| » W: Danny Jackson (2-2) L: Jim Deshaies (3-4) S: Rob Dibble (7) | Fifth | 14 out |
| Sunday, June 17 |
| » Lost to Reds (39-20), 7-1 | Riverfront Stadium (0-3) | 26-37 | Lost 3 |
| » W: Jose Rijo (5-2) L: Mark Portugal (1-7) | Fifth | 15 out |
| Monday, June 18 |
| » Lost to Dodgers (31-33), 5-2 | Dodger Stadium (2-3) | 26-38 | Lost 4 |
| » W: Tim Belcher (5-4) L: Bill Gullickson (4-5) S: Jay Howell (3) | Fifth | 15½ out |
| Tuesday, June 19 |
| » Lost to Dodgers (32-33), 5-1 | Dodger Stadium (2-4) | 26-39 | Lost 5 |
| » W: Fernando Valenzuela (5-5) L: Mike Scott (4-7) | Fifth | 16 out |
| Wednesday, June 20 |
| » Lost to Dodgers (33-33), 3-2 | Dodger Stadium (2-5) | 26-40 | Lost 6 |
| » W: Ramon Martinez (8-3) L: Jim Clancy (2-7) S: Jay Howell (4) | Fifth | 17 out |
| Friday, June 22 |
| » Lost to Giants (36-32), 4-3 | Astrodome (17-16) | 26-41 | Lost 7 |
| » W: Scott Garrelts (5-6) L: Jim Deshaies (3-5) S: Jeff Brantley (9) | Fifth | 16½ out |
| Saturday, June 23 |
| » Defeated Giants (36-33), 4-2 | Astrodome (18-16) | 27-41 | |
| » W: Mark Portugal (2-7) L: Steve Bedrosian (3-5) S: Dave Smith (14) | Fifth | 16½ out |
| Sunday, June 24 |
| » Defeated Giants (36-34), 8-2 | Astrodome (19-16) | 28-41 | Won 2 |
| » W: Bill Gullickson (5-5) L: Don Robinson (2-1) | Fifth | 16½ out |
| Monday, June 25 |
| » Defeated Padres (34-33), 5-3 | Astrodome (20-16) | 29-41 | Won 3 |
| » W: Mike Scott (5-7) L: Andy Benes (6-5) S: Dave Smith (15) | Fifth | 16½ out |
| Tuesday, June 26 |
| » Lost to Padres (35-33), 7-0 | Astrodome (20-17) | 29-42 | |
| » W: Dennis Rasmussen (7-4) L: Jim Clancy (2-8) | Fifth | 17½ out |
| Wednesday, June 27 |
| » Defeated Padres (35-34), 9-1 | Astrodome (21-17) | 30-42 | |
| » W: Jim Deshaies (4-5) L: Bruce Hurst (4-7) | Fifth | 16½ out |
| Thursday, June 28 |
| » Defeated Padres (35-35), 2-1 | Astrodome (22-17) | 31-42 | Won 2 |
| » W: Larry Andersen (4-1) L: Mark Grant (1-1) | Fifth | 15½ out |
| Friday, June 29 |
| » Lost to Phillies (35-36), 2-0 | Veteran's Stadium (1-2) | 31-43 | |
| » W: Pat Combs (4-6) L: Bill Gullickson (5-6) | Fifth | 15½ out |
| Saturday, June 30 |
| » Defeated Phillies (35-37), 8-3 | Veteran's Stadium (2-2) | 32-43 | |
| » W: Mike Scott (6-7) L: Marvin Freeman (0-2) S: Juan Agosto (1) | Fifth | 15½ out |
| Sunday, July 1 |
| » Lost to Phillies (36-37), 8-4 | Veteran's Stadium (2-3) | 32-44 | |
| » W: Roger McDowell (3-3) L: Larry Andersen (4-2) | Fifth | 15½ out |
| Monday, July 2 |
| » Lost to Phillies (37-37), 5-1 | Veteran's Stadium (2-4) | 32-45 | Lost 2 |
| » W: Bruce Ruffin (6-7) L: Jim Deshaies (4-6) S: Darrel Akerfelds (1) | Sixth | 16 out |
| Tuesday, July 3 |
| » Lost to Mets (43-30), 12-0 | Shea Stadium (1-4) | 32-46 | Lost 3 |
| » W: Frank Viola (12-3) L: Mark Portugal (2-8) | Sixth | 17 out |
| Wednesday, July 4 |
| » Lost to Mets (44-30), 7-4 | Shea Stadium (1-5) | 32-47 | Lost 4 |
| » W: Dwight Gooden (8-5) L: Juan Agosto (4-2) S: John Franco (15) | Sixth | 17 out |
| Thursday, July 5 |
| » Lost to Expos (45-36), 11-0 | Stade Olympique (1-2) | 32-48 | Lost 5 |
| » W: Mark Gardner (5-4) L: Mike Scott (6-8) | Sixth | 18 out |
| Friday, July 6 |
| » Lost to Expos (46-36), 3-2 | Stade Olympique (1-3) | 32-49 | Lost 6 |
| » W: Bill Sampen (7-1) L: Juan Agosto (4-3) S: Dave Schmidt (11) | Sixth | 19 out |
| Saturday, July 7 |
| » Lost to Expos (47-36), 3-1 | Stade Olympique (1-4) | 32-50 | Lost 7 |
| » W: Zane Smith (5-6) L: Jim Deshaies (4-7) S: Dave Schmidt (12) | Sixth | 20 out |
| Sunday, July 8 |
| » Defeated Expos (47-37), 5-3 | Stade Olympique (2-4) | 33-50 | |
| » W: Mark Portugal (3-8) L: Dennis Martinez (6-7) S: Dave Smith (16) | Sixth | 19 out |
| Thursday, July 12 |
| » Defeated Phillies (39-42), 7-4 | Astrodome (23-17) | 34-50 | Won 2 |
| » W: Bill Gullickson (6-6) L: Bruce Ruffin (6-9) S: Dave Smith (17) | Sixth | 18½ out |
| Friday, July 13 |
| » Lost to Phillies (40-42), 4-2 | Astrodome (23-18) | 34-51 | |
| » W: Jose DeJesus (1-2) L: Mike Scott (6-9) S: Darrel Akerfelds (2) | Sixth | 19½ out |
| Saturday, July 14 |
| » Lost to Phillies (41-42), 12-8 | Astrodome (23-19) | 34-52 | Lost 2 |
| » W: Pat Combs (5-7) L: Jim Deshaies (4-8) | Sixth | 19½ out |
| Sunday, July 15 |
| » Defeated Phillies (41-43), 6-1 | Astrodome (24-19) | 35-52 | |
| » W: Danny Darwin (3-1) L: Jeff Parrett (3-7) | Sixth | 19½ out |
| Monday, July 16 |
| » Defeated Mets (49-35), 4-1 | Astrodome (25-19) | 36-52 | Won 2 |
| » W: Mark Portugal (4-8) L: Bob Ojeda (4-4) S: Larry Andersen (3) | Fifth | 19½ out |
| Tuesday, July 17 |
| » Lost to Mets (50-35), 6-2 | Astrodome (25-20) | 36-53 | |
| » W: Dwight Gooden (10-5) L: Bill Gullickson (6-7) S: John Franco (19) | Sixth | 20½ out |
| Wednesday, July 18 |
| » Defeated Mets (50-36), 1-0 | Astrodome (26-20) | 37-53 | |
| » W: Mike Scott (7-9) L: Alejandro Pena (2-3) | Fifth | 20½ out |
| Thursday, July 19 |
| » Defeated Expos (50-42), 4-3 | Astrodome (27-20) | 38-53 | Won 2 |
| » W: Larry Andersen (5-2) L: Bill Sampen (7-2) | Fifth | 19½ out |
| Friday, July 20 |
| » Defeated Expos (50-43), 12-6 | Astrodome (28-20) | 39-53 | Won 3 |
| » W: Danny Darwin (4-1) L: Kevin Gross (8-6) | Fifth | 19½ out |
| Saturday, July 21 |
| » Lost to Expos (51-43), 3-2 | Astrodome (28-21) | 39-54 | |
| » W: Zane Smith (6-7) L: Juan Agosto (4-4) S: Tim Burke (12) | Fifth | 20½ out |
| Sunday, July 22 |
| » Defeated Expos (51-44), 3-2 | Astrodome (29-21) | 40-54 | |
| » W: Juan Agosto (5-4) L: Dave Schmidt (3-3) S: Dave Smith (18) | Fourth | 19½ out |
| Monday, July 23 |
| » Lost to Braves (37-55), 3-1 | Atlanta-Fulton County Stadium (1-1) | 40-55 | |
| » W: John Smoltz (7-7) L: Mike Scott (7-10) | Fourth | 20½ out |
| Tuesday, July 24 |
| » Lost to Braves (38-55), 9-3 | Atlanta-Fulton County Stadium (1-2) | 40-56 | Lost 2 |
| » W: Charlie Leibrandt (4-3) L: Jim Deshaies (4-9) | Sixth | 21 out |
| » Lost to Braves (39-55), 9-8 | Atlanta-Fulton County Stadium (1-3) | 40-57 | Lost 3 |
| » W: Kent Mercker (4-1) L: Juan Agosto (5-5) | Sixth | 21 out |
| Wednesday, July 25 |
| » Defeated Braves (39-56), 5-1 | Atlanta-Fulton County Stadium (2-3) | 41-57 | |
| » W: Danny Darwin (5-1) L: Steve Avery (1-5) | Fifth | 19½ out |
| Thursday, July 26 |
| » Lost to Padres (42-54), 8-2 | San Diego/Jack Murphy Stadium (0-4) | 41-58 | |
| » W: Eric Show (2-8) L: Mark Portugal (4-9) | Fifth | 19½ out |
| Friday, July 27 |
| » Lost to Padres (43-54), 6-2 | San Diego/Jack Murphy Stadium (0-5) | 41-59 | Lost 2 |
| » W: Andy Benes (7-7) L: Bill Gullickson (6-8) | Fifth | 19½ out |
| Saturday, July 28 |
| » Defeated Padres (43-55), 5-3 | San Diego/Jack Murphy Stadium (1-5) | 42-59 | |
| » W: Mike Scott (8-10) L: Dennis Rasmussen (7-9) S: Larry Andersen (4) | Fifth | 18½ out |
| Sunday, July 29 |
| » Lost to Padres (44-55), 4-3 | San Diego/Jack Murphy Stadium (1-6) | 42-60 | |
| » W: Greg Harris (5-5) L: Dave Smith (2-3) S: Craig Lefferts (14) | Fifth | 18½ out |
| Monday, July 30 |
| » Defeated Giants (54-47), 6-1 | Candlestick Park (2-3) | 43-60 | |
| » W: Danny Darwin (6-1) L: Steve Bedrosian (5-6) | Fifth | 17½ out |
| Tuesday, July 31 |
| » Lost to Giants (55-47), 3-2 | Candlestick Park (2-4) | 43-61 | |
| » W: Jeff Brantley (4-3) L: Juan Agosto (5-6) | Fifth | 18½ out |
| » Major-league debuts: Rafael Novoa (Giants) |
| Thursday, August 2 |
| » Defeated Braves (40-62), 3-1 | Astrodome (30-21) | 44-61 | |
| » W: Bill Gullickson (7-8) L: Tom Glavine (6-7) S: Larry Andersen (5) | Fifth | 18 out |
| Friday, August 3 |
| » Defeated Braves (40-63), 3-0 | Astrodome (31-21) | 45-61 | Won 2 |
| » W: Mike Scott (9-10) L: John Smoltz (7-8) | Fifth | 17 out |
| Saturday, August 4 |
| » Defeated Braves (40-64), 6-2 | Astrodome (32-21) | 46-61 | Won 3 |
| » W: Jim Deshaies (5-9) L: Charlie Leibrandt (4-5) | Fifth | 16 out |
| Sunday, August 5 |
| » Defeated Braves (40-65), 6-2 | Astrodome (33-21) | 47-61 | Won 4 |
| » W: Danny Darwin (7-1) L: Steve Avery (1-6) | Fifth | 16 out |
| Monday, August 6 |
| » Defeated Giants (58-50), 4-1 | Astrodome (34-21) | 48-61 | Won 5 |
| » W: Bill Gullickson (8-8) L: Don Robinson (8-2) | Fifth | 15½ out |
| Tuesday, August 7 |
| » Defeated Giants (58-51), 4-0 | Astrodome (35-21) | 49-61 | Won 6 |
| » W: Mark Portugal (5-9) L: John Burkett (10-4) S: Dave Smith (19) | Fifth | 15½ out |
| » Major-league debuts: Tuffy Rhodes (Astros) |
| Wednesday, August 8 |
| » Lost to Giants (59-51), 8-4 | Astrodome (35-22) | 49-62 | |
| » W: Trevor Wilson (8-3) L: Juan Agosto (5-7) S: Mark Thurmond (4) | Fifth | 15½ out |
| Friday, August 10 |
| » Lost to Padres (52-59), 2-0 | Astrodome (35-23) | 49-63 | Lost 2 |
| » W: Ed Whitson (9-7) L: Jim Deshaies (5-10) S: Craig Lefferts (17) | Fifth | 16 out |
| Saturday, August 11 |
| » Lost to Padres (53-59), 6-3 | Astrodome (35-24) | 49-64 | Lost 3 |
| » W: Eric Show (4-8) L: Dave Smith (2-4) S: Craig Lefferts (18) | Fifth | 16 out |
| Sunday, August 12 |
| » Lost to Padres (54-59), 9-0 | Astrodome (35-25) | 49-65 | Lost 4 |
| » W: Derek Lilliquist (3-8) L: Bill Gullickson (8-9) | Fifth | 17 out |
| Monday, August 13 |
| » Defeated Cubs (55-60), 7-2 | Wrigley Field (3-1) | 50-65 | |
| » W: Mark Portugal (6-9) L: Lance Dickson (0-2) | Fifth | 17 out |
| Tuesday, August 14 |
| » Lost to Cubs (56-60), 5-2 | Wrigley Field (3-2) | 50-66 | |
| » W: Greg Maddux (10-10) L: Mike Scott (9-11) S: Bill Long (4) | Fifth | 18 out |
| Wednesday, August 15 |
| » Defeated Cubs (56-61), 8-4 | Wrigley Field (4-2) | 51-66 | |
| » W: Dave Smith (3-4) L: Jeff Pico (4-3) | Fourth | 18 out |
| Thursday, August 16 |
| » Defeated Cardinals (54-64), 4-2 | Busch Stadium II (1-2) | 52-66 | Won 2 |
| » W: Danny Darwin (8-1) L: Joe Magrane (8-13) S: Dave Smith (20) | Fourth | 17½ out |
| Friday, August 17 |
| » Lost to Cardinals (55-64), 5-0 | Busch Stadium II (1-3) | 52-67 | |
| » W: Bob Tewksbury (8-3) L: Bill Gullickson (8-10) | Fourth | 17 out |
| Saturday, August 18 |
| » Defeated Cardinals (55-65), 3-2 | Busch Stadium II (2-3) | 53-67 | |
| » W: Dave Smith (4-4) L: Frank DiPino (4-2) | Fifth | 16 out |
| » Major-league debuts: Omar Olivares (Cardinals) |
| Sunday, August 19 |
| » Lost to Cardinals (56-65), 7-3 | Busch Stadium II (2-4) | 53-68 | |
| » W: Jose DeLeon (7-12) L: Mike Scott (9-12) | Fifth | 16 out |
| Monday, August 20 |
| » Lost to Pirates (72-49), 7-1 | Three Rivers Stadium (0-4) | 53-69 | Lost 2 |
| » W: Neal Heaton (11-8) L: Jim Deshaies (5-11) | Fifth | 16 out |
| Tuesday, August 21 |
| » Defeated Pirates (72-50), 2-1 | Three Rivers Stadium (1-4) | 54-69 | |
| » W: Danny Darwin (9-1) L: Bob Patterson (8-4) | Fifth | 16 out |
| Wednesday, August 22 |
| » Lost to Pirates (73-50), 4-2 | Three Rivers Stadium (1-5) | 54-70 | |
| » W: John Smiley (7-6) L: Bill Gullickson (8-11) S: Bill Landrum (13) | Fifth | 17 out |
| Thursday, August 23 |
| » Defeated Braves (47-77), 8-3 | Atlanta-Fulton County Stadium (3-3) | 55-70 | |
| » W: Mark Portugal (7-9) L: Charlie Leibrandt (5-8) | Fifth | 16 out |
| Friday, August 24 |
| » Lost to Cardinals (58-67), 3-2 | Astrodome (35-26) | 55-71 | |
| » W: Scott Terry (2-6) L: Dave Smith (4-5) S: Lee Smith (26) | Fourth | 17 out |
| Saturday, August 25 |
| » Defeated Cardinals (58-68), 6-4 | Astrodome (36-26) | 56-71 | |
| » W: Jim Deshaies (6-11) L: Jose DeLeon (7-13) S: Juan Agosto (2) | Fourth | 17 out |
| Sunday, August 26 |
| » Defeated Cardinals (58-69), 4-2 | Astrodome (37-26) | 57-71 | Won 2 |
| » W: Danny Darwin (10-1) L: Ken Hill (4-2) | Fifth | 17 out |
| Tuesday, August 28 |
| » Lost to Cubs (61-66), 5-2 | Astrodome (37-27) | 57-72 | |
| » W: Greg Maddux (12-11) L: Bill Gullickson (8-12) | Fifth | 18 out |
| Wednesday, August 29 |
| » Defeated Cubs (61-67), 1-0 | Astrodome (38-27) | 58-72 | |
| » W: Mark Portugal (8-9) L: Rick Sutcliffe (0-1) S: Larry Andersen (6) | Fifth | 17 out |
| Friday, August 31 |
| » Defeated Pirates (75-55), 3-2 | Astrodome (39-27) | 59-72 | Won 2 |
| » W: Juan Agosto (6-7) L: Bob Patterson (8-5) | Fifth | 16½ out |
| Saturday, September 1 |
| » Defeated Pirates (75-56), 2-1 | Astrodome (40-27) | 60-72 | Won 3 |
| » W: Dave Smith (5-5) L: Ted Power (1-3) | Fifth | 16½ out |
| Sunday, September 2 |
| » Lost to Pirates (76-56), 7-6 | Astrodome (40-28) | 60-73 | |
| » W: John Smiley (8-7) L: Danny Darwin (10-2) S: Bob Kipper (3) | Fifth | 17½ out |
| » Major-league debuts: Andujar Cedeno and Al Osuna (Astros) |
| Monday, September 3 |
| » Defeated Dodgers (71-63), 7-3 | Dodger Stadium (3-5) | 61-73 | |
| » W: Bill Gullickson (9-12) L: Fernando Valenzuela (12-11) S: Dave Smith (21) | Fifth | 16½ out |
| Tuesday, September 4 |
| » Defeated Dodgers (71-64), 10-8 | Dodger Stadium (4-5) | 62-73 | Won 2 |
| » W: Al Osuna (1-0) L: Jim Gott (2-4) S: Dave Smith (22) | Fourth | 15½ out |
| » Major-league debuts: Luis Gonzalez (Astros) |
| Wednesday, September 5 |
| » Lost to Padres (62-73), 5-2 | San Diego/Jack Murphy Stadium (1-7) | 62-74 | |
| » W: Dennis Rasmussen (9-13) L: Mike Scott (9-13) S: Craig Lefferts (23) | Fifth | 16½ out |
| » Major-league debuts: Mike Simms (Astros) |
| Thursday, September 6 |
| » Lost to Padres (63-73), 3-0 | San Diego/Jack Murphy Stadium (1-8) | 62-75 | Lost 2 |
| » W: Greg Harris (8-7) L: Brian Meyer (0-1) | Fifth | 16½ out |
| » Major-league debuts: Paul Faries (Padres) |
| Friday, September 7 |
| » Defeated Giants (70-68), 2-1 | Candlestick Park (3-4) | 63-75 | |
| » W: Danny Darwin (11-2) L: John Burkett (11-7) S: Dave Smith (23) | Fifth | 15½ out |
| Saturday, September 8 |
| » Lost to Giants (71-68), 2-1 | Candlestick Park (3-5) | 63-76 | |
| » W: Steve Bedrosian (7-8) L: Brian Meyer (0-2) | Fifth | 16½ out |
| Sunday, September 9 |
| » Lost to Giants (72-68), 5-1 | Candlestick Park (3-6) | 63-77 | Lost 2 |
| » W: Mike LaCoss (6-3) L: Mark Portugal (8-10) | Fifth | 16½ out |
| Tuesday, September 11 |
| » Lost to Reds (80-60), 5-3 | Riverfront Stadium (0-4) | 63-78 | Lost 3 |
| » W: Norm Charlton (12-7) L: Jim Deshaies (6-12) S: Randy Myers (29) | Fourth | 17½ out |
| Wednesday, September 12 |
| » Defeated Reds (80-61), 3-1 | Riverfront Stadium (1-4) | 64-78 | |
| » W: Juan Agosto (7-7) L: Tim Layana (5-3) S: Brian Meyer (1) | Fourth | 16½ out |
| Thursday, September 13 |
| » Lost to Reds (81-61), 7-5 | Riverfront Stadium (1-5) | 64-79 | |
| » W: Rob Dibble (7-3) L: Brian Meyer (0-3) | Fourth | 17½ out |
| Friday, September 14 |
| » Defeated Giants (75-69), 2-1 | Astrodome (41-28) | 65-79 | |
| » W: Mark Portugal (9-10) L: Kelly Downs (1-1) S: Juan Agosto (3) | Fifth | 16½ out |
| Saturday, September 15 |
| » Defeated Giants (75-70), 3-2 | Astrodome (42-28) | 66-79 | Won 2 |
| » W: Xavier Hernandez (1-0) L: Steve Bedrosian (8-9) | Fifth | 15½ out |
| Sunday, September 16 |
| » Defeated Giants (75-71), 3-2 | Astrodome (43-28) | 67-79 | Won 3 |
| » W: Juan Agosto (8-7) L: Don Robinson (10-6) | Fifth | 15½ out |
| » Major-league debuts: Andres Santana (Giants) |
| Monday, September 17 |
| » Lost to Padres (69-77), 5-0 | Astrodome (43-29) | 67-80 | |
| » W: Bruce Hurst (10-9) L: Danny Darwin (11-3) | Fifth | 16½ out |
| » Major-league debuts: Randy Hennis (Astros) |
| Tuesday, September 18 |
| » Lost to Padres (70-77), 8-1 | Astrodome (43-30) | 67-81 | Lost 2 |
| » W: Ed Whitson (13-8) L: Bill Gullickson (9-13) | Fifth | 16½ out |
| Wednesday, September 19 |
| » Defeated Reds (83-65), 5-2 | Astrodome (44-30) | 68-81 | |
| » W: Mark Portugal (10-10) L: Danny Jackson (5-6) S: Juan Agosto (4) | Fifth | 15½ out |
| Thursday, September 20 |
| » Defeated Reds (83-66), 3-2 | Astrodome (45-30) | 69-81 | Won 2 |
| » W: Xavier Hernandez (2-0) L: Randy Myers (3-5) | Fifth | |