| Friday, January 13 |
| Former White Sox Ray Morehart dies in Dallas, TX at the age of 90. |
| Tuesday, April 4 |
| » Defeated Angels (0-1), 9-2 | Anaheim Stadium (1-0) | 1-0 | |
| » W: Jerry Reuss (1-0) L: Mike Witt (0-1) S: Donn Pall (1) | First | -- |
| Wednesday, April 5 |
| » Lost to Angels (1-1), 6-2 | Anaheim Stadium (1-1) | 1-1 | |
| » W: Chuck Finley (1-0) L: Eric King (0-1) S: Greg Minton (1) | Third | 1 out |
| Thursday, April 6 |
| » Defeated Angels (1-2), 3-2 | Anaheim Stadium (2-1) | 2-1 | |
| » W: Ken Patterson (1-0) L: Willie Fraser (0-1) S: Donn Pall (2) | Third | 1 out |
| Friday, April 7 |
| » Defeated Athletics (3-1), 7-1 | Oakland-Alameda County Stadium (1-0) | 3-1 | Won 2 |
| » W: Bill Long (1-0) L: Curt Young (0-1) S: Barry Jones (1) | First | -- |
| » Major-league debuts: Jeff Schaefer (White Sox) |
| Saturday, April 8 |
| » Defeated Athletics (3-2), 7-4 | Oakland-Alameda County Stadium (2-0) | 4-1 | Won 3 |
| » W: Melido Perez (1-0) L: Mike Moore (0-1) S: Bobby Thigpen (1) | First | -- |
| Sunday, April 9 |
| » Lost to Athletics (4-2), 4-2 | Oakland-Alameda County Stadium (2-1) | 4-2 | |
| » W: Dave Stewart (2-0) L: Jerry Reuss (1-1) S: Dennis Eckersley (2) | Second | ½ out |
| Monday, April 10 |
| » Lost to Mariners (2-5), 6-5 | Kingdome (0-1) | 4-3 | Lost 2 |
| » W: Jerry Reed (1-0) L: Eric King (0-2) S: Mike Schooler (1) | Fourth | 1½ out |
| Tuesday, April 11 |
| » Defeated Mariners (2-6), 8-6 | Kingdome (1-1) | 5-3 | |
| » W: Barry Jones (1-0) L: Tom Niedenfuer (0-1) S: Bobby Thigpen (2) | Fourth | 1 out |
| Wednesday, April 12 |
| » Lost to Mariners (3-6), 9-1 | Kingdome (1-2) | 5-4 | |
| » W: Erik Hanson (1-1) L: Bill Long (1-1) | Fourth | 2 out |
| » Major-league debuts: Matt Merullo (White Sox) |
| Friday, April 14 |
| » Lost to Athletics (7-4), 7-4 | Comiskey Park I (0-1) | 5-5 | Lost 2 |
| » W: Dave Stewart (3-0) L: Melido Perez (1-1) | Fifth | 3½ out |
| Saturday, April 15 |
| » Defeated Athletics (7-5), 7-4 | Comiskey Park I (1-1) | 6-5 | |
| » W: Jerry Reuss (2-1) L: Bob Welch (2-1) S: Bobby Thigpen (3) | Fifth | 3½ out |
| Sunday, April 16 |
| » Lost to Athletics (8-5), 3-2 | Comiskey Park I (1-2) | 6-6 | |
| » W: Dennis Eckersley (1-0) L: Eric King (0-3) | Sixth | 4½ out |
| Former White Sox Jocko Conlan dies in Scottsdale, AZ at the age of 90. |
| Monday, April 17 |
| » Lost to Angels (8-6), 3-0 | Comiskey Park I (1-3) | 6-7 | Lost 2 |
| » W: Kirk McCaskill (3-0) L: Shawn Hillegas (0-1) S: Bryan Harvey (2) | Fifth | 4½ out |
| Wednesday, April 19 |
| » Lost to Angels (9-6), 7-2 | Comiskey Park I (1-4) | 6-8 | Lost 3 |
| » W: Mike Witt (2-2) L: Bill Long (1-2) S: Greg Minton (2) | Sixth | 6 out |
| Thursday, April 20 |
| » Lost to Mariners (6-10), 5-2 | Comiskey Park I (1-5) | 6-9 | Lost 4 |
| » W: Scott Bankhead (1-1) L: Barry Jones (1-1) | Sixth | 6½ out |
| Friday, April 21 |
| » Lost to Mariners (7-10), 11-1 | Comiskey Park I (1-6) | 6-10 | Lost 5 |
| » W: Mike Campbell (1-2) L: Jerry Reuss (2-2) | Sixth | 6½ out |
| Saturday, April 22 |
| » Defeated Mariners (7-11), 1-0 | Comiskey Park I (2-6) | 7-10 | |
| » W: Eric King (1-3) L: Erik Hanson (2-2) | Sixth | 5½ out |
| Sunday, April 23 |
| » Lost to Mariners (8-11), 10-6 | Comiskey Park I (2-7) | 7-11 | |
| » W: Steve Trout (1-1) L: Shawn Hillegas (0-2) | Seventh | 6½ out |
| Tuesday, April 25 |
| » Lost to Red Sox (8-9), 11-0 | Fenway Park (0-1) | 7-12 | Lost 2 |
| » W: Roger Clemens (3-0) L: Melido Perez (1-2) | Seventh | 7½ out |
| Wednesday, April 26 |
| » Lost to Red Sox (9-9), 5-4 | Fenway Park (0-2) | 7-13 | Lost 3 |
| » W: Bob Stanley (1-1) L: Barry Jones (1-2) | Seventh | 8½ out |
| Thursday, April 27 |
| » Defeated Red Sox (9-10), 3-1 | Fenway Park (1-2) | 8-13 | |
| » W: Donn Pall (1-0) L: Mike Smithson (0-2) | Seventh | 8 out |
| Friday, April 28 |
| » Lost to Yankees (10-12), 3-1 | Yankee Stadium (0-1) | 8-14 | |
| » W: Andy Hawkins (3-2) L: Shawn Hillegas (0-3) S: Dave Righetti (4) | Seventh | 8½ out |
| Saturday, April 29 |
| » Lost to Yankees (11-12), 8-2 | Yankee Stadium (0-2) | 8-15 | Lost 2 |
| » W: Dave LaPoint (3-1) L: Bill Long (1-3) S: Dale Mohorcic (2) | Seventh | 9 out |
| Sunday, April 30 |
| » Lost to Yankees (12-12), 5-2 | Yankee Stadium (0-3) | 8-16 | Lost 3 |
| » W: John Candelaria (3-2) L: Melido Perez (1-3) S: Lance McCullers (1) | Seventh | 10 out |
| Monday, May 1 |
| » Defeated Brewers (10-13), 6-0 | Comiskey Park I (3-7) | 9-16 | |
| » W: Jerry Reuss (3-2) L: Teddy Higuera (0-1) | Seventh | 9 out |
| Tuesday, May 2 |
| » Defeated Brewers (10-14), 6-1 | Comiskey Park I (4-7) | 10-16 | Won 2 |
| » W: Eric King (2-3) L: Chris Bosio (4-1) | Seventh | 8 out |
| Wednesday, May 3 |
| » Lost to Red Sox (13-12), 8-4 | Comiskey Park I (4-8) | 10-17 | |
| » W: Mike Boddicker (2-2) L: Shawn Hillegas (0-4) S: Bob Stanley (3) | Seventh | 9 out |
| Thursday, May 4 |
| » Defeated Red Sox (13-13), 5-4 | Comiskey Park I (5-8) | 11-17 | |
| » W: Bill Long (2-3) L: Wes Gardner (1-2) S: Bobby Thigpen (4) | Sixth | 8 out |
| Friday, May 5 |
| » Lost to Yankees (14-14), 7-5 | Comiskey Park I (5-9) | 11-18 | |
| » W: Lance McCullers (1-0) L: Donn Pall (1-1) S: Lee Guetterman (4) | Seventh | 9 out |
| Saturday, May 6 |
| » Lost to Yankees (15-14), 5-2 | Comiskey Park I (5-10) | 11-19 | Lost 2 |
| » W: Dave Righetti (1-1) L: Steve Rosenberg (0-1) | Seventh | 9 out |
| Sunday, May 7 |
| » Defeated Yankees (15-15), 6-2 | Comiskey Park I (6-10) | 12-19 | |
| » W: Eric King (3-3) L: Tommy John (2-5) S: Bobby Thigpen (5) | Sixth | 9 out |
| Tuesday, May 9 |
| » Defeated Brewers (14-16), 10-1 | County Stadium (1-0) | 13-19 | Won 2 |
| » W: Shawn Hillegas (1-4) L: Bill Wegman (2-4) | Sixth | 9 out |
| Wednesday, May 10 |
| » Defeated Brewers (14-17), 12-2 | County Stadium (2-0) | 14-19 | Won 3 |
| » W: Melido Perez (2-3) L: Teddy Higuera (0-2) | Sixth | 8½ out |
| Friday, May 12 |
| » Lost to Orioles (15-17), 9-6 | Memorial Stadium (0-1) | 14-20 | |
| » W: Mark Thurmond (1-1) L: Tom McCarthy (0-1) S: Kevin Hickey (1) | Sixth | 9 out |
| Saturday, May 13 |
| » Defeated Orioles (15-18), 8-2 | Memorial Stadium (1-1) | 15-20 | |
| » W: Eric King (4-3) L: Bob Milacki (1-4) | Sixth | 9 out |
| Sunday, May 14 |
| » Defeated Orioles (15-19), 8-5 | Memorial Stadium (2-1) | 16-20 | Won 2 |
| » W: Steve Rosenberg (1-1) L: Mark Williamson (0-2) S: Bobby Thigpen (6) | Sixth | 8 out |
| Monday, May 15 |
| » Lost to Tigers (12-23), 3-2 | Tiger Stadium (0-1) | 16-21 | |
| » W: Frank Tanana (3-4) L: Bill Long (2-4) S: Willie Hernandez (7) | Sixth | 9 out |
| Tuesday, May 16 |
| » Lost to Tigers (13-23), 9-7 | Tiger Stadium (0-2) | 16-22 | Lost 2 |
| » W: Frank Williams (2-2) L: Melido Perez (2-4) | Fifth | 9 out |
| Wednesday, May 17 |
| » Defeated Tigers (13-24), 10-7 | Tiger Stadium (1-2) | 17-22 | |
| » W: Ken Patterson (2-0) L: Willie Hernandez (1-1) S: Shawn Hillegas (1) | Sixth | 9 out |
| Friday, May 19 |
| » Lost to Blue Jays (15-25), 9-3 | Comiskey Park I (6-11) | 17-23 | |
| » W: Mike Flanagan (3-3) L: Eric King (4-4) | Sixth | 9½ out |
| Saturday, May 20 |
| » Lost to Blue Jays (16-25), 11-1 | Comiskey Park I (6-12) | 17-24 | Lost 2 |
| » W: Jimmy Key (5-2) L: Shawn Hillegas (1-5) | Seventh | 10½ out |
| Sunday, May 21 |
| » Lost to Blue Jays (17-25), 9-3 | Comiskey Park I (6-13) | 17-25 | Lost 3 |
| » W: John Cerutti (1-2) L: Melido Perez (2-5) S: Duane Ward (3) | Seventh | 11½ out |
| Monday, May 22 |
| » Lost to Orioles (19-21), 5-1 | Comiskey Park I (6-14) | 17-26 | Lost 4 |
| » W: Dave Schmidt (3-4) L: Steve Rosenberg (1-2) | Seventh | 12 out |
| Tuesday, May 23 |
| » Lost to Orioles (20-21), 9-3 | Comiskey Park I (6-15) | 17-27 | Lost 5 |
| » W: Bob Milacki (2-4) L: Bill Long (2-5) | Seventh | 12 out |
| Wednesday, May 24 |
| » Lost to Orioles (21-21), 8-0 | Comiskey Park I (6-16) | 17-28 | Lost 6 |
| » W: Jay Tibbs (1-0) L: Eric King (4-5) S: Mark Williamson (5) | Seventh | 13 out |
| Friday, May 26 |
| » Lost to Blue Jays (19-27), 11-3 | Exhibition Stadium (0-1) | 17-29 | Lost 7 |
| » W: Jimmy Key (6-2) L: Shawn Hillegas (1-6) | Seventh | 13½ out |
| Saturday, May 27 |
| » Defeated Blue Jays (19-28), 5-3 | Exhibition Stadium (1-1) | 18-29 | |
| » W: Melido Perez (3-5) L: John Cerutti (1-3) S: Bobby Thigpen (7) | Seventh | 13½ out |
| Sunday, May 28 |
| » Lost to Blue Jays (20-28), 7-5 | Exhibition Stadium (1-2) | 18-30 | |
| » W: Tom Henke (3-3) L: Bobby Thigpen (0-1) | Seventh | 14½ out |
| Monday, May 29 |
| » Lost to Tigers (20-28), 4-2 | Comiskey Park I (6-17) | 18-31 | Lost 2 |
| » W: Doyle Alexander (4-4) L: Eric King (4-6) S: Willie Hernandez (10) | Seventh | 14½ out |
| Tuesday, May 30 |
| » Lost to Tigers (21-28), 10-3 | Comiskey Park I (6-18) | 18-32 | Lost 3 |
| » W: Frank Tanana (5-4) L: Jeff Bittiger (0-1) S: Frank Williams (1) | Seventh | 15½ out |
| Wednesday, May 31 |
| » Lost to Tigers (22-28), 4-3 | Comiskey Park I (6-19) | 18-33 | Lost 4 |
| » W: Mike Henneman (3-1) L: Bobby Thigpen (0-2) S: Willie Hernandez (11) | Seventh | 15½ out |
| » Major-league debuts: Greg Hibbard (White Sox) |
| Friday, June 2 |
| » Lost to Twins (24-27), 8-0 | Comiskey Park I (6-20) | 18-34 | Lost 5 |
| » W: Allan Anderson (6-3) L: Melido Perez (3-6) | Seventh | 15½ out |
| Saturday, June 3 |
| » Lost to Twins (25-27), 5-4 | Comiskey Park I (6-21) | 18-35 | Lost 6 |
| » W: Frank Viola (4-7) L: Eric King (4-7) S: Jeff Reardon (8) | Seventh | 16 out |
| » Defeated Twins (25-28), 2-1 | Comiskey Park I (7-21) | 19-35 | |
| » W: Shawn Hillegas (2-6) L: Shane Rawley (3-5) S: Bobby Thigpen (8) | Seventh | 16 out |
| Sunday, June 4 |
| » Defeated Twins (25-29), 2-1 | Comiskey Park I (8-21) | 20-35 | Won 2 |
| » W: Jerry Reuss (4-2) L: Roy Smith (4-3) S: Bobby Thigpen (9) | Seventh | 16 out |
| Monday, June 5 |
| » Lost to Rangers (30-24), 4-2 | Arlington Stadium (0-1) | 20-36 | |
| » W: Bobby Witt (5-5) L: Greg Hibbard (0-1) S: Jeff Russell (11) | Seventh | 16 out |
| Tuesday, June 6 |
| » Lost to Rangers (31-24), 3-1 | Arlington Stadium (0-2) | 20-37 | Lost 2 |
| » W: Kevin Brown (5-2) L: Melido Perez (3-7) S: Jeff Russell (12) | Seventh | 17 out |
| Wednesday, June 7 |
| » Defeated Rangers (31-25), 6-4 | Arlington Stadium (1-2) | 21-37 | |
| » W: Ken Patterson (3-0) L: Cecilio Guante (3-3) S: Bobby Thigpen (10) | Seventh | 17 out |
| Thursday, June 8 |
| » Lost to Rangers (32-25), 11-7 | Arlington Stadium (1-3) | 21-38 | |
| » W: Nolan Ryan (7-3) L: Eric King (4-8) S: Jeff Russell (13) | Seventh | 17½ out |
| Former White Sox Bibb Falk dies in Austin, TX at the age of 91. |
| Friday, June 9 |
| » Defeated Twins (26-32), 8-3 | Hubert H. Humphrey Metrodome (1-0) | 22-38 | |
| » W: Jerry Reuss (5-2) L: Shane Rawley (3-6) S: Shawn Hillegas (2) | Seventh | 16½ out |
| Saturday, June 10 |
| » Lost to Twins (27-32), 11-8 | Hubert H. Humphrey Metrodome (1-1) | 22-39 | |
| » W: Juan Berenguer (3-2) L: Bobby Thigpen (0-3) S: Jeff Reardon (10) | Seventh | 17½ out |
| Sunday, June 11 |
| » Lost to Twins (28-32), 5-2 | Hubert H. Humphrey Metrodome (1-2) | 22-40 | Lost 2 |
| » W: Allan Anderson (7-4) L: Melido Perez (3-8) S: Jeff Reardon (11) | Seventh | 18½ out |
| Monday, June 12 |
| » Defeated Indians (29-32), 5-3 | Comiskey Park I (9-21) | 23-40 | |
| » W: Steve Rosenberg (2-2) L: Rich Yett (4-5) S: Bobby Thigpen (11) | Seventh | 17½ out |
| Tuesday, June 13 |
| » Lost to Indians (30-32), 9-6 | Comiskey Park I (9-22) | 23-41 | |
| » W: Greg Swindell (8-1) L: Adam Peterson (0-1) S: Doug Jones (14) | Seventh | 17½ out |
| Wednesday, June 14 |
| » Defeated Indians (30-33), 3-1 | Comiskey Park I (10-22) | 24-41 | |
| » W: Jerry Reuss (6-2) L: Tom Candiotti (7-4) S: Bobby Thigpen (12) | Seventh | 17½ out |
| Friday, June 16 |
| » Lost to Red Sox (29-32), 2-0 | Comiskey Park I (10-23) | 24-42 | |
| » W: Roger Clemens (8-4) L: Ken Patterson (3-1) | Seventh | 18 out |
| Saturday, June 17 |
| » Lost to Red Sox (30-32), 6-1 | Comiskey Park I (10-24) | 24-43 | Lost 2 |
| » W: Mike Smithson (3-4) L: Melido Perez (3-9) | Seventh | 18 out |
| Sunday, June 18 |
| » Lost to Red Sox (31-32), 7-4 | Comiskey Park I (10-25) | 24-44 | Lost 3 |
| » W: Joe Price (2-3) L: Steve Rosenberg (2-3) S: Lee Smith (7) | Seventh | 18 out |
| Monday, June 19 |
| » Defeated Red Sox (31-33), 8-2 | Comiskey Park I (11-25) | 25-44 | |
| » W: Shawn Hillegas (3-6) L: John Dopson (6-5) S: Donn Pall (3) | Seventh | 17 out |
| Tuesday, June 20 |
| » Defeated Yankees (33-35), 13-6 | Yankee Stadium (1-3) | 26-44 | Won 2 |
| » W: Jerry Reuss (7-2) L: Richard Dotson (2-5) S: John Davis (1) | Seventh | 17 out |
| Wednesday, June 21 |
| » Defeated Yankees (33-36), 7-3 | Yankee Stadium (2-3) | 27-44 | Won 3 |
| » W: Donn Pall (2-1) L: Andy Hawkins (7-8) | Seventh | 17 out |
| Thursday, June 22 |
| » Lost to Yankees (34-36), 10-7 | Yankee Stadium (2-4) | 27-45 | |
| » W: Greg Cadaret (1-0) L: Shawn Hillegas (3-7) S: Dave Righetti (12) | Seventh | 17 out |
| Friday, June 23 |
| » Lost to Brewers (34-38), 17-5 | County Stadium (2-1) | 27-46 | Lost 2 |
| » W: Chris Bosio (7-4) L: Steve Rosenberg (2-4) | Seventh | 16½ out |
| » Defeated Brewers (34-39), 6-4 | County Stadium (3-1) | 28-46 | |
| » W: Melido Perez (4-9) L: Bryan Clutterbuck (2-5) S: Bobby Thigpen (13) | Seventh | 16½ out |
| Saturday, June 24 |
| » Defeated Brewers (34-40), 5-3 | County Stadium (4-1) | 29-46 | Won 2 |
| » W: Bill Long (3-5) L: Bill Krueger (3-2) S: Bobby Thigpen (14) | Seventh | 16½ out |
| Sunday, June 25 |
| » Lost to Brewers (35-40), 3-1 | County Stadium (4-2) | 29-47 | |
| » W: Jaime Navarro (1-0) L: Jerry Reuss (7-3) S: Dan Plesac (18) | Seventh | 17½ out |
| Tuesday, June 27 |
| » Lost to Rangers (42-33), 5-1 | Comiskey Park I (11-26) | 29-48 | Lost 2 |
| » W: Kevin Brown (7-4) L: Greg Hibbard (0-2) S: Jeff Russell (18) | Seventh | 17 out |
| Wednesday, June 28 |
| » Lost to Rangers (43-33), 10-5 | Comiskey Park I (11-27) | 29-49 | Lost 3 |
| » W: Mike Jeffcoat (4-1) L: Steve Rosenberg (2-5) | Seventh | 17 out |
| Thursday, June 29 |
| » Defeated Royals (43-33), 12-5 | Comiskey Park I (12-27) | 30-49 | |
| » W: Melido Perez (5-9) L: Terry Leach (1-2) | Seventh | 16½ out |
| Friday, June 30 |
| » Lost to Royals (44-33), 6-3 | Comiskey Park I (12-28) | 30-50 | |
| » W: Charlie Leibrandt (5-8) L: Jerry Reuss (7-4) S: Jeff Montgomery (2) | Seventh | 17½ out |
| Saturday, July 1 |
| » Defeated Royals (44-34), 6-4 | Comiskey Park I (13-28) | 31-50 | |
| » W: Shawn Hillegas (4-7) L: Luis Aquino (3-3) S: Bobby Thigpen (15) | Seventh | 17½ out |
| Sunday, July 2 |
| » Defeated Royals (44-35), 7-3 | Comiskey Park I (14-28) | 32-50 | Won 2 |
| » W: Greg Hibbard (1-2) L: Kevin Appier (1-4) S: Donn Pall (4) | Sixth | 17½ out |
| Monday, July 3 |
| » Lost to Indians (37-43), 4-2 | Cleveland Stadium (0-1) | 32-51 | |
| » W: Bud Black (7-7) L: Shawn Hillegas (4-8) S: Doug Jones (19) | Sixth | 18½ out |
| Tuesday, July 4 |
| » Lost to Indians (38-43), 3-2 | Cleveland Stadium (0-2) | 32-52 | Lost 2 |
| » W: Scott Bailes (4-3) L: Melido Perez (5-10) S: Doug Jones (20) | Seventh | 18½ out |
| Wednesday, July 5 |
| » Lost to Indians (39-43), 4-2 | Cleveland Stadium (0-3) | 32-53 | Lost 3 |
| » W: Greg Swindell (11-2) L: Jerry Reuss (7-5) S: Doug Jones (21) | Seventh | 19 out |
| Friday, July 7 |
| » Lost to Royals (47-37), 4-2 | Royals Stadium (0-1) | 32-54 | Lost 4 |
| » W: Terry Leach (2-2) L: Richard Dotson (2-6) S: Steve Farr (16) | Seventh | 19½ out |
| Saturday, July 8 |
| » Lost to Royals (48-37), 4-3 | Royals Stadium (0-2) | 32-55 | Lost 5 |
| » W: Jeff Montgomery (7-1) L: John Davis (0-1) | Seventh | 20½ out |
| Sunday, July 9 |
| » Lost to Royals (49-37), 5-4 | Royals Stadium (0-3) | 32-56 | Lost 6 |
| » W: Tom Gordon (10-2) L: Shawn Hillegas (4-9) | Seventh | 21½ out |
| Thursday, July 13 |
| » Defeated Brewers (42-46), 5-4 | Comiskey Park I (15-28) | 33-56 | |
| » W: Bobby Thigpen (1-3) L: Tony Fossas (1-1) | Seventh | 21½ out |
| Friday, July 14 |
| » Defeated Brewers (42-47), 6-4 | Comiskey Park I (16-28) | 34-56 | Won 2 |
| » W: Bill Long (4-5) L: Chris Bosio (9-6) S: Donn Pall (5) | Seventh | 20½ out |
| Saturday, July 15 |
| » Defeated Brewers (42-48), 2-1 | Comiskey Park I (17-28) | 35-56 | Won 3 |
| » W: Melido Perez (6-10) L: Teddy Higuera (3-4) S: Bobby Thigpen (16) | Seventh | 19½ out |
| Sunday, July 16 |
| » Defeated Brewers (42-49), 2-0 | Comiskey Park I (18-28) | 36-56 | Won 4 |
| » W: Richard Dotson (3-6) L: Jaime Navarro (1-2) S: Bobby Thigpen (17) | Seventh | 18½ out |
| Monday, July 17 |
| » Defeated Yankees (46-46), 7-3 | Comiskey Park I (19-28) | 37-56 | Won 5 |
| » W: Steve Rosenberg (3-5) L: Dave LaPoint (6-7) S: Shawn Hillegas (3) | Seventh | 17 out |
| Wednesday, July 19 |
| » Defeated Yankees (46-47), 11-5 | Comiskey Park I (20-28) | 38-56 | Won 6 |
| » W: Shawn Hillegas (5-9) L: Lee Guetterman (2-3) S: Bobby Thigpen (18) | Seventh | 17 out |
| Friday, July 21 |
| » Defeated Red Sox (44-47), 1-0 | Fenway Park (2-2) | 39-56 | Won 7 |
| » W: Melido Perez (7-10) L: Eric Hetzel (1-1) S: Bobby Thigpen (19) | Seventh | 17½ out |
| Saturday, July 22 |
| » Defeated Red Sox (44-48), 10-6 | Fenway Park (3-2) | 40-56 | Won 8 |
| » W: Ken Patterson (4-1) L: Rob Murphy (1-5) S: Donn Pall (6) | Seventh | 17½ out |
| Sunday, July 23 |
| » Lost to Red Sox (45-48), 8-2 | Fenway Park (3-3) | 40-57 | |
| » W: Roger Clemens (11-7) L: Steve Rosenberg (3-6) | Seventh | 18½ out |
| Monday, July 24 |
| » Defeated Mariners (48-50), 5-4 | Comiskey Park I (21-28) | 41-57 | |
| » W: Shawn Hillegas (6-9) L: Mike Jackson (3-4) | Sixth | 18½ out |
| Tuesday, July 25 |
| » Defeated Mariners (48-51), 7-6 | Comiskey Park I (22-28) | 42-57 | Won 2 |
| » W: Donn Pall (3-1) L: Mike Jackson (3-5) S: Bobby Thigpen (20) | Sixth | 18½ out |
| Wednesday, July 26 |
| » Defeated Mariners (48-52), 5-3 | Comiskey Park I (23-28) | 43-57 | Won 3 |
| » W: Greg Hibbard (2-2) L: Bill Swift (6-3) S: Bobby Thigpen (21) | Sixth | 17½ out |
| Thursday, July 27 |
| » Lost to Angels (61-39), 8-5 | Anaheim Stadium (2-2) | 43-58 | |
| » W: Jim Abbott (9-6) L: Melido Perez (7-11) S: Bryan Harvey (14) | Seventh | 18½ out |
| Friday, July 28 |
| » Lost to Angels (62-39), 6-5 | Anaheim Stadium (2-3) | 43-59 | Lost 2 |
| » W: Bryan Harvey (3-2) L: Donn Pall (3-2) | Seventh | 19½ out |
| Saturday, July 29 |
| » Lost to Angels (63-39), 2-1 | Anaheim Stadium (2-4) | 43-60 | Lost 3 |
| » W: Kirk McCaskill (10-6) L: Steve Rosenberg (3-7) S: Bryan Harvey (15) | Seventh | 20½ out |
| Sunday, July 30 |
| » Defeated Angels (63-40), 3-2 | Anaheim Stadium (3-4) | 44-60 | |
| » W: Jerry Reuss (8-5) L: Chuck Finley (12-7) S: Bobby Thigpen (22) | Seventh | 19½ out |
| Monday, July 31 |
| » Lost to Athletics (63-42), 3-2 | Oakland-Alameda County Stadium (2-2) | 44-61 | |
| » W: Mike Moore (14-5) L: Bobby Thigpen (1-4) | Seventh | 19½ out |
| Tuesday, August 1 |
| » Lost to Athletics (64-42), 2-0 | Oakland-Alameda County Stadium (2-3) | 44-62 | Lost 2 |
| » W: Curt Young (3-8) L: Greg Hibbard (2-3) S: Dennis Eckersley (19) | Seventh | 20 out |
| Wednesday, August 2 |
| » Lost to Athletics (65-42), 2-0 | Oakland-Alameda County Stadium (2-4) | 44-63 | Lost 3 |
| » W: Storm Davis (10-5) L: Melido Perez (7-12) S: Rick Honeycutt (12) | Seventh | 21 out |
| Thursday, August 3 |
| » Defeated Athletics (65-43), 6-4 | Oakland-Alameda County Stadium (3-4) | 45-63 | |
| » W: Donn Pall (4-2) L: Bob Welch (11-6) S: Bobby Thigpen (23) | Seventh | 20½ out |
| Friday, August 4 |
| » Defeated Tigers (38-69), 5-4 | Comiskey Park I (24-28) | 46-63 | Won 2 |
| » W: Ken Patterson (5-1) L: Paul Gibson (2-7) | Seventh | 20½ out |
| Saturday, August 5 |
| » Defeated Tigers (38-70), 7-6 | Comiskey Park I (25-28) | 47-63 | Won 3 |
| » W: Eric King (5-8) L: Doyle Alexander (5-12) S: Bobby Thigpen (24) | Seventh | 19½ out |
| Sunday, August 6 |
| » Lost to Tigers (39-70), 4-3 | Comiskey Park I (25-29) | 47-64 | |
| » W: Frank Tanana (8-9) L: Greg Hibbard (2-4) | Seventh | 20½ out |
| Tuesday, August 8 |
| » Lost to Athletics (68-45), 3-2 | Comiskey Park I (25-30) | 47-65 | Lost 2 |
| » W: Rick Honeycutt (2-1) L: Donn Pall (4-3) S: Dennis Eckersley (22) | Seventh | 20½ out |
| Wednesday, August 9 |
| » Defeated Athletics (68-46), 3-2 | Comiskey Park I (26-30) | 48-65 | |
| » W: Tom McCarthy (1-1) L: Jim Corsi (0-2) | Seventh | 20½ out |
| Thursday, August 10 |
| » Lost to Athletics (69-46), 4-1 | Comiskey Park I (26-31) | 48-66 | |
| » W: Storm Davis (12-5) L: Steve Rosenberg (3-8) S: Dennis Eckersley (23) | Seventh | 20½ out |
| Friday, August 11 |
| » Defeated Mariners (55-60), 9-6 | Kingdome (2-2) | 49-66 | |
| » W: Bobby Thigpen (2-4) L: Mike Schooler (1-3) | Seventh | 20½ out |
| Saturday, August 12 |
| » Lost to Mariners (56-60), 4-3 | Kingdome (2-3) | 49-67 | |
| » W: Jerry Reed (5-6) L: Donn Pall (4-4) | Seventh | 21½ out |
| Sunday, August 13 |
| » Defeated Mariners (56-61), 6-4 | Kingdome (3-3) | 50-67 | |
| » W: Bill Long (5-5) L: Keith Comstock (1-1) S: Bobby Thigpen (25) | Seventh | 20½ out |
| Monday, August 14 |
| » Defeated Royals (64-53), 4-3 | Comiskey Park I (27-31) | 51-67 | Won 2 |
| » W: Ken Patterson (6-1) L: Luis Aquino (6-7) S: Bobby Thigpen (26) | Seventh | 20 out |
| Tuesday, August 15 |
| » Lost to Royals (65-53), 10-6 | Comiskey Park I (27-32) | 51-68 | |
| » W: Terry Leach (3-3) L: Tom McCarthy (1-2) | Seventh | 21 out |
| Wednesday, August 16 |
| » Lost to Royals (66-53), 5-4 | Comiskey Park I (27-33) | 51-69 | Lost 2 |
| » W: Bret Saberhagen (14-5) L: Bobby Thigpen (2-5) S: Jeff Montgomery (8) | Seventh | 21 out |
| Thursday, August 17 |
| » Defeated Rangers (62-57), 6-1 | Comiskey Park I (28-33) | 52-69 | |
| » W: Greg Hibbard (3-4) L: Kevin Brown (11-7) | Seventh | 21 out |
| Friday, August 18 |
| » Lost to Rangers (63-57), 6-5 | Comiskey Park I (28-34) | 52-70 | |
| » W: Mike Jeffcoat (6-5) L: Melido Perez (7-13) S: Jeff Russell (27) | Seventh | 21 out |
| Saturday, August 19 |
| » Lost to Rangers (64-57), 7-6 | Comiskey Park I (28-35) | 52-71 | Lost 2 |
| » W: Bobby Witt (10-10) L: Richard Dotson (3-7) S: Jeff Russell (28) | Seventh | 22 out |
| Sunday, August 20 |
| » Lost to Rangers (65-57), 7-1 | Comiskey Park I (28-36) | 52-72 | Lost 3 |
| » W: Charlie Hough (8-12) L: Steve Rosenberg (3-9) | Seventh | 23 out |
| Tuesday, August 22 |
| » Defeated Twins (60-64), 10-2 | Hubert H. Humphrey Metrodome (2-2) | 53-72 | |
| » W: Eric King (6-8) L: Shane Rawley (5-12) | Seventh | 23½ out |
| Wednesday, August 23 |
| » Lost to Twins (61-64), 8-7 | Hubert H. Humphrey Metrodome (2-3) | 53-73 | |
| » W: Roy Smith (10-4) L: Greg Hibbard (3-5) | Seventh | 24½ out |
| Thursday, August 24 |
| » Lost to Twins (62-64), 6-4 | Hubert H. Humphrey Metrodome (2-4) | 53-74 | Lost 2 |
| » W: Juan Berenguer (8-3) L: Shawn Hillegas (6-10) S: Jeff Reardon (24) | Seventh | 24½ out |
| Friday, August 25 |
| » Defeated Indians (61-67), 5-4 | Cleveland Stadium (1-3) | 54-74 | |
| » W: Richard Dotson (4-7) L: Jesse Orosco (1-4) S: Bobby Thigpen (27) | Seventh | 23½ out |
| Former White Sox Jim Brideweser dies in ElToro, CA at the age of 63. |
| Saturday, August 26 |
| » Defeated Indians (61-68), 4-3 | Cleveland Stadium (2-3) | 55-74 | Won 2 |
| » W: Steve Rosenberg (4-9) L: Bud Black (9-11) S: Bobby Thigpen (28) | Seventh | 22½ out |
| Sunday, August 27 |
| » Defeated Indians (61-69), 9-3 | Cleveland Stadium (3-3) | 56-74 | Won 3 |
| » W: Greg Hibbard (4-5) L: John Farrell (7-13) | Seventh | 22½ out |
| Tuesday, August 29 |
| » Lost to Blue Jays (70-62), 3-2 | Skydome (0-1) | 56-75 | |
| » W: Mike Flanagan (8-8) L: Donn Pall (4-5) S: Tom Henke (14) | Seventh | 24 out |
| Wednesday, August 30 |
| » Lost to Blue Jays (71-62), 2-1 | Skydome (0-2) | 56-76 | Lost 2 |
| » W: Jimmy Key (10-13) L: Richard Dotson (4-8) S: Duane Ward (14) | Seventh | 24 out |
| Thursday, August 31 |
| » Lost to Blue Jays (72-62), 5-1 | Skydome (0-3) | 56-77 | Lost 3 |
| » W: Dave Stieb (14-8) L: Steve Rosenberg (4-10) | Sixth | 24½ out |
| Friday, September 1 |
| » Defeated Orioles (72-63), 10-1 | Comiskey Park I (29-36) | 57-77 | |
| » W: Eric King (7-8) L: Bob Milacki (9-12) | Seventh | 23½ out |
| Saturday, September 2 |
| » Lost to Orioles (73-63), 2-1 | Comiskey Park I (29-37) | 57-78 | |
| » W: Brian Holton (5-6) L: Greg Hibbard (4-6) S: Gregg Olson (23) | Seventh | 24½ out |
| Sunday, September 3 |
| » Defeated Orioles (73-64), 4-2 | Comiskey Park I (30-37) | 58-78 | |
| » W: Melido Perez (8-13) L: Jeff Ballard (15-7) S: Bobby Thigpen (29) | Seventh | 24½ out |
| Monday, September 4 |
| » Lost to Blue Jays (75-63), 5-2 | Comiskey Park I (30-38) | 58-79 | |
| » W: Jimmy Key (11-13) L: Richard Dotson (4-9) S: Tom Henke (16) | Seventh | 24½ out |
| Tuesday, September 5 |
| » Lost to Blue Jays (76-63), 6-1 | Comiskey Park I (30-39) | 58-80 | Lost 2 |
| » W: Dave Stieb (15-8) L: Steve Rosenberg (4-11) | Seventh | 25½ out |
| Wednesday, September 6 |
| » Lost to Blue Jays (77-63), 4-2 | Comiskey Park I (30-40) | 58-81 | Lost 3 |
| » W: Todd Stottlemyre (7-5) L: Eric King (7-9) S: Duane Ward (15) | Seventh | 26½ out |
| Friday, September 8 |
| » Lost to Tigers (54-89), 7-5 | Tiger Stadium (1-3) | 58-82 | Lost 4 |
| » W: Jack Morris (5-11) L: Greg Hibbard (4-7) S: Mike Henneman (7) | Seventh | 26½ out |
| Saturday, September 9 |
| » Defeated Tigers (54-90), 13-3 | Tiger Stadium (2-3) | 59-82 | |
| » W: Melido Perez (9-13) L: Jeff Robinson (4-5) | Seventh | 26½ out |
| Sunday, September 10 |
| » Lost to Tigers (55-90), 6-5 | Tiger Stadium (2-4) | 59-83 | |
| » W: Mike Henneman (10-4) L: Bobby Thigpen (2-6) | Seventh | 27½ out |
| Monday, September 11 |
| » Lost to Orioles (79-67), 6-3 | Memorial Stadium (2-2) | 59-84 | Lost 2 |
| » W: Jeff Ballard (17-7) L: Steve Rosenberg (4-12) S: Gregg Olson (25) | Seventh | 28 out |
| » Major-league debuts: Wayne Edwards (White Sox) |
| Tuesday, September 12 |
| » Defeated Orioles (79-68), 11-1 | Memorial Stadium (3-2) | 60-84 | |
| » W: Eric King (8-9) L: Pete Harnisch (4-9) | Seventh | 27 out |
| » Major-league debuts: Robin Ventura (White Sox) |
| Wednesday, September 13 |
| » Defeated Orioles (79-69), 3-0 | Memorial Stadium (4-2) | 61-84 | Won 2 |
| » W: Greg Hibbard (5-7) L: Dave Johnson (4-5) S: Bobby Thigpen (30) | Seventh | 27 out |
| Friday, September 15 |
| » Defeated Angels (84-62), 3-1 | Comiskey Park I (31-40) | 62-84 | Won 3 |
| » W: Melido Perez (10-13) L: Jim Abbott (11-11) | Sixth | |