| Monday, April 3 |
| » Defeated Red Sox (0-1), 5-4 | Memorial Stadium (1-0) | 1-0 | |
| » W: Brian Holton (1-0) L: Bob Stanley (0-1) | First | -- |
| » Major-league debuts: Steve Finley (Orioles) |
| Thursday, April 6 |
| » Defeated Red Sox (0-2), 6-4 | Memorial Stadium (2-0) | 2-0 | Won 2 |
| » W: Jose Bautista (1-0) L: Mike Smithson (0-1) S: Mark Williamson (1) | First | -- |
| Friday, April 7 |
| » Lost to Twins (3-1), 8-3 | Hubert H. Humphrey Metrodome (0-1) | 2-1 | |
| » W: Roy Smith (1-0) L: Bob Milacki (0-1) | First | -- |
| » Major-league debuts: Gary Wayne (Twins) |
| Saturday, April 8 |
| » Lost to Twins (4-1), 6-5 | Hubert H. Humphrey Metrodome (0-2) | 2-2 | Lost 2 |
| » W: German Gonzalez (1-0) L: Brian Holton (1-1) S: Jeff Reardon (1) | Second | 1 out |
| Sunday, April 9 |
| » Defeated Twins (4-2), 8-1 | Hubert H. Humphrey Metrodome (1-2) | 3-2 | |
| » W: Jeff Ballard (1-0) L: Frank Viola (0-2) | Second | 1 out |
| Monday, April 10 |
| » Lost to Royals (5-2), 3-0 | Royals Stadium (0-1) | 3-3 | |
| » W: Bret Saberhagen (1-0) L: Pete Harnisch (0-1) | Second | 1 out |
| Tuesday, April 11 |
| » Lost to Royals (6-2), 6-5 | Royals Stadium (0-2) | 3-4 | Lost 2 |
| » W: Floyd Bannister (1-0) L: Jose Bautista (1-1) S: Steve Farr (2) | Third | 1½ out |
| Wednesday, April 12 |
| » Defeated Royals (6-3), 5-4 | Royals Stadium (1-2) | 4-4 | |
| » W: Gregg Olson (1-0) L: Steve Farr (0-1) | Second | 1½ out |
| Thursday, April 13 |
| » Major-league debuts: Derek Lilliquist (Braves) |
| Friday, April 14 |
| » Lost to Red Sox (4-5), 7-4 | Fenway Park (0-1) | 4-5 | |
| » W: John Dopson (2-0) L: Dave Schmidt (0-1) S: Bob Stanley (1) | Third | 1 out |
| Saturday, April 15 |
| » Defeated Red Sox (4-6), 12-4 | Fenway Park (1-1) | 5-5 | |
| » W: Jeff Ballard (2-0) L: Mike Boddicker (1-1) S: Gregg Olson (1) | First | -- |
| Monday, April 17 |
| » Lost to Red Sox (5-6), 6-4 | Fenway Park (1-2) | 5-6 | |
| » W: Lee Smith (1-1) L: Brian Holton (1-2) S: Bob Stanley (2) | Third | 1 out |
| Tuesday, April 18 |
| » Lost to Royals (8-5), 7-4 | Memorial Stadium (2-1) | 5-7 | Lost 2 |
| » W: Tom Gordon (2-0) L: Mark Williamson (0-1) S: Steve Farr (3) | Fourth | 1 out |
| Wednesday, April 19 |
| » Defeated Royals (8-6), 6-5 | Memorial Stadium (3-1) | 6-7 | |
| » W: Dave Schmidt (1-1) L: Charlie Leibrandt (0-2) S: Mark Williamson (2) | Second | ½ out |
| Thursday, April 20 |
| » Defeated Royals (8-7), 2-0 | Memorial Stadium (4-1) | 7-7 | Won 2 |
| » W: Jeff Ballard (3-0) L: Bret Saberhagen (1-2) S: Mark Williamson (3) | Second | ½ out |
| Friday, April 21 |
| » Lost to Twins (9-5), 7-1 | Memorial Stadium (4-2) | 7-8 | |
| » W: Allan Anderson (4-0) L: Jose Bautista (1-2) | Second | ½ out |
| Saturday, April 22 |
| » Defeated Twins (9-6), 4-1 | Memorial Stadium (5-2) | 8-8 | |
| » W: Gregg Olson (2-0) L: Freddie Toliver (1-1) | First | -- |
| Sunday, April 23 |
| » Defeated Twins (9-7), 3-0 | Memorial Stadium (6-2) | 9-8 | Won 2 |
| » W: Bob Milacki (1-1) L: Shane Rawley (1-2) | First | -- |
| Monday, April 24 |
| » Lost to Angels (10-9), 3-2 | Anaheim Stadium (0-1) | 9-9 | |
| » W: Jim Abbott (1-2) L: Dave Schmidt (1-2) S: Bryan Harvey (3) | First | -- |
| Tuesday, April 25 |
| » Defeated Angels (10-10), 8-1 | Anaheim Stadium (1-1) | 10-9 | |
| » W: Jeff Ballard (4-0) L: Mike Witt (2-3) | First | -- |
| » Major-league debuts: Chris Hoiles (Orioles) |
| Wednesday, April 26 |
| » Defeated Athletics (15-7), 2-1 | Oakland-Alameda County Stadium (1-0) | 11-9 | Won 2 |
| » W: Jose Bautista (2-2) L: Bob Welch (3-2) S: Gregg Olson (2) | First | -- |
| Thursday, April 27 |
| » Lost to Athletics (16-7), 9-4 | Oakland-Alameda County Stadium (1-1) | 11-10 | |
| » W: Todd Burns (1-0) L: Mark Thurmond (0-1) | Second | 1 out |
| Friday, April 28 |
| » Lost to Mariners (10-14), 11-5 | Kingdome (0-1) | 11-11 | Lost 2 |
| » W: Jerry Reed (2-2) L: Brian Holton (1-3) | Second | 1 out |
| Saturday, April 29 |
| » Lost to Mariners (11-14), 4-3 | Kingdome (0-2) | 11-12 | Lost 3 |
| » W: Mark Langston (3-3) L: Dave Schmidt (1-3) S: Mike Schooler (2) | First | -- |
| Sunday, April 30 |
| » Defeated Mariners (11-15), 4-3 | Kingdome (1-2) | 12-12 | |
| » W: Jeff Ballard (5-0) L: Steve Trout (2-2) S: Mark Williamson (4) | First | -- |
| Monday, May 1 |
| » Major-league debuts: Dwight Smith (Cubs) |
| Tuesday, May 2 |
| » Defeated Angels (15-11), 4-3 | Memorial Stadium (7-2) | 13-12 | Won 2 |
| » W: Gregg Olson (3-0) L: Willie Fraser (0-2) | First | -- |
| Wednesday, May 3 |
| » Lost to Angels (16-11), 2-0 | Memorial Stadium (7-3) | 13-13 | |
| » W: Rich Monteleone (1-0) L: Bob Milacki (1-2) | Second | ½ out |
| Saturday, May 6 |
| » Lost to Mariners (15-15), 2-1 | Memorial Stadium (7-4) | 13-14 | Lost 2 |
| » W: Mark Langston (4-3) L: Dave Schmidt (1-4) S: Mike Schooler (5) | Fourth | 2 out |
| » Lost to Mariners (16-15), 6-5 | Memorial Stadium (7-5) | 13-15 | Lost 3 |
| » W: Scott Bankhead (2-2) L: Jeff Ballard (5-1) S: Mike Schooler (6) | Fourth | 2 out |
| Sunday, May 7 |
| » Lost to Mariners (17-15), 5-3 | Memorial Stadium (7-6) | 13-16 | Lost 4 |
| » W: Bill Swift (1-0) L: Jose Bautista (2-3) S: Dennis Powell (1) | Fifth | 3 out |
| Monday, May 8 |
| » Lost to Athletics (22-10), 6-1 | Memorial Stadium (7-7) | 13-17 | Lost 5 |
| » W: Mike Moore (4-2) L: Bob Milacki (1-3) | Fifth | 3 out |
| Thursday, May 11 |
| » Defeated Athletics (22-11), 6-2 | Memorial Stadium (8-7) | 14-17 | |
| » W: Jeff Ballard (6-1) L: Dave Stewart (6-1) | Fourth | 2 out |
| Friday, May 12 |
| » Defeated White Sox (14-20), 9-6 | Memorial Stadium (9-7) | 15-17 | Won 2 |
| » W: Mark Thurmond (1-1) L: Tom McCarthy (0-1) S: Kevin Hickey (1) | Third | 2 out |
| Saturday, May 13 |
| » Lost to White Sox (15-20), 8-2 | Memorial Stadium (9-8) | 15-18 | |
| » W: Eric King (4-3) L: Bob Milacki (1-4) | Fourth | 2 out |
| Sunday, May 14 |
| » Lost to White Sox (16-20), 8-5 | Memorial Stadium (9-9) | 15-19 | Lost 2 |
| » W: Steve Rosenberg (1-1) L: Mark Williamson (0-2) S: Bobby Thigpen (6) | Third | 2 out |
| Wednesday, May 17 |
| » Defeated Rangers (20-16), 8-2 | Arlington Stadium (1-0) | 16-19 | |
| » W: Dave Schmidt (2-4) L: Charlie Hough (2-5) | Fourth | 1 out |
| Thursday, May 18 |
| » Defeated Indians (18-20), 3-2 | Memorial Stadium (10-9) | 17-19 | Won 2 |
| » W: Mark Williamson (1-2) L: Keith Atherton (0-3) | Third | ½ out |
| Friday, May 19 |
| » Lost to Indians (19-20), 4-1 | Memorial Stadium (10-10) | 17-20 | |
| » W: Tom Candiotti (5-2) L: Jose Bautista (2-4) S: Doug Jones (8) | Fourth | 1½ out |
| Saturday, May 20 |
| » Defeated Indians (19-21), 5-1 | Memorial Stadium (11-10) | 18-20 | |
| » W: Jeff Ballard (7-1) L: John Farrell (2-4) | Third | ½ out |
| Sunday, May 21 |
| » Lost to Indians (20-21), 2-0 | Memorial Stadium (11-11) | 18-21 | |
| » W: Rich Yett (4-2) L: Brian Holton (1-4) S: Doug Jones (9) | Fourth | 1 out |
| Monday, May 22 |
| » Defeated White Sox (17-26), 5-1 | Comiskey Park I (1-0) | 19-21 | |
| » W: Dave Schmidt (3-4) L: Steve Rosenberg (1-2) | Third | 1 out |
| Tuesday, May 23 |
| » Defeated White Sox (17-27), 9-3 | Comiskey Park I (2-0) | 20-21 | Won 2 |
| » W: Bob Milacki (2-4) L: Bill Long (2-5) | First | -- |
| Wednesday, May 24 |
| » Defeated White Sox (17-28), 8-0 | Comiskey Park I (3-0) | 21-21 | Won 3 |
| » W: Jay Tibbs (1-0) L: Eric King (4-5) S: Mark Williamson (5) | First | -- |
| Friday, May 26 |
| » Defeated Indians (21-25), 5-2 | Cleveland Stadium (1-0) | 22-21 | Won 4 |
| » W: Jeff Ballard (8-1) L: Rich Yett (4-3) S: Gregg Olson (3) | First | -- |
| Saturday, May 27 |
| » Defeated Indians (21-26), 5-1 | Cleveland Stadium (2-0) | 23-21 | Won 5 |
| » W: Dave Schmidt (4-4) L: Bud Black (3-6) S: Mark Huismann (1) | First | -- |
| Sunday, May 28 |
| » Lost to Indians (22-26), 1-0 | Cleveland Stadium (2-1) | 23-22 | |
| » W: Greg Swindell (5-1) L: Bob Milacki (2-5) | First | -- |
| Monday, May 29 |
| » Defeated Rangers (27-20), 6-1 | Memorial Stadium (12-11) | 24-22 | |
| » W: Brian Holton (2-4) L: Nolan Ryan (5-3) | First | -- |
| Tuesday, May 30 |
| » Defeated Rangers (27-21), 6-2 | Memorial Stadium (13-11) | 25-22 | Won 2 |
| » W: Mark Williamson (2-2) L: Jamie Moyer (3-5) S: Gregg Olson (4) | First | -- |
| Wednesday, May 31 |
| » Defeated Rangers (27-22), 8-5 | Memorial Stadium (14-11) | 26-22 | Won 3 |
| » W: Mark Williamson (3-2) L: Bobby Witt (4-5) S: Gregg Olson (5) | First | -- |
| Thursday, June 1 |
| » Defeated Tigers (22-29), 8-3 | Tiger Stadium (1-0) | 27-22 | Won 4 |
| » W: Dave Schmidt (5-4) L: Randy Nosek (0-2) S: Mark Thurmond (1) | First | -- |
| Friday, June 2 |
| » Defeated Tigers (22-30), 4-1 | Tiger Stadium (2-0) | 28-22 | Won 5 |
| » W: Bob Milacki (3-5) L: Mike Trujillo (1-2) S: Kevin Hickey (2) | First | -- |
| Saturday, June 3 |
| » Defeated Tigers (22-31), 4-2 | Tiger Stadium (3-0) | 29-22 | Won 6 |
| » W: Kevin Hickey (1-0) L: Doyle Alexander (4-5) S: Gregg Olson (6) | First | -- |
| Sunday, June 4 |
| » Defeated Tigers (22-32), 7-4 | Tiger Stadium (4-0) | 30-22 | Won 7 |
| » W: Jay Tibbs (2-0) L: Frank Tanana (5-5) S: Mark Williamson (6) | First | -- |
| Monday, June 5 |
| » Defeated Yankees (25-30), 16-3 | Yankee Stadium (1-0) | 31-22 | Won 8 |
| » W: Jeff Ballard (9-1) L: Andy Hawkins (5-7) | First | -- |
| Tuesday, June 6 |
| » Lost to Yankees (26-30), 4-0 | Yankee Stadium (1-1) | 31-23 | |
| » W: Dave LaPoint (6-4) L: Dave Schmidt (5-5) | First | -- |
| Thursday, June 8 |
| » Lost to Brewers (27-31), 6-2 | Memorial Stadium (14-12) | 31-24 | Lost 2 |
| » W: Mark Knudson (2-1) L: Bob Milacki (3-6) | First | -- |
| Friday, June 9 |
| » Defeated Brewers (27-32), 7-1 | Memorial Stadium (15-12) | 32-24 | |
| » W: Mark Williamson (4-2) L: Bryan Clutterbuck (2-4) | First | -- |
| Saturday, June 10 |
| » Lost to Brewers (28-32), 6-0 | Memorial Stadium (15-13) | 32-25 | |
| » W: Don August (6-6) L: Jeff Ballard (9-2) | First | -- |
| Sunday, June 11 |
| » Lost to Brewers (29-32), 3-1 | Memorial Stadium (15-14) | 32-26 | Lost 2 |
| » W: Chuck Crim (5-3) L: Kevin Hickey (1-1) S: Dan Plesac (14) | First | -- |
| Tuesday, June 13 |
| » Defeated Yankees (29-32), 5-2 | Memorial Stadium (16-14) | 33-26 | |
| » W: Dave Schmidt (6-5) L: Dave LaPoint (6-5) S: Gregg Olson (7) | First | -- |
| Wednesday, June 14 |
| » Lost to Yankees (30-32), 2-1 | Memorial Stadium (16-15) | 33-27 | |
| » W: Lee Guetterman (1-0) L: Kevin Hickey (1-2) S: Dave Righetti (10) | First | -- |
| Thursday, June 15 |
| » Defeated Yankees (30-33), 3-2 | Memorial Stadium (17-15) | 34-27 | |
| » W: Mark Thurmond (2-1) L: Lance McCullers (2-2) | First | -- |
| Friday, June 16 |
| » Lost to Athletics (42-23), 7-5 | Memorial Stadium (17-16) | 34-28 | |
| » W: Storm Davis (5-3) L: Brian Holton (2-5) S: Rick Honeycutt (6) | First | -- |
| » Defeated Athletics (42-24), 5-1 | Memorial Stadium (18-16) | 35-28 | |
| » W: Jay Tibbs (3-0) L: Mike Moore (8-5) | First | -- |
| Saturday, June 17 |
| » Defeated Athletics (42-25), 4-2 | Memorial Stadium (19-16) | 36-28 | Won 2 |
| » W: Jose Bautista (3-4) L: Matt Young (0-1) S: Gregg Olson (8) | First | -- |
| Sunday, June 18 |
| » Defeated Athletics (42-26), 4-2 | Memorial Stadium (20-16) | 37-28 | Won 3 |
| » W: Dave Schmidt (7-5) L: Curt Young (2-7) S: Mickey Weston (1) | First | -- |
| » Major-league debuts: Mickey Weston (Orioles) |
| Monday, June 19 |
| » Defeated Mariners (32-38), 9-5 | Kingdome (2-2) | 38-28 | Won 4 |
| » W: Bob Milacki (4-6) L: Mike Jackson (2-2) S: Mark Thurmond (2) | First | -- |
| Tuesday, June 20 |
| » Defeated Mariners (32-39), 8-6 | Kingdome (3-2) | 39-28 | Won 5 |
| » W: Mickey Weston (1-0) L: Jerry Reed (3-5) S: Gregg Olson (9) | First | -- |
| Wednesday, June 21 |
| » Defeated Mariners (32-40), 8-6 | Kingdome (4-2) | 40-28 | Won 6 |
| » W: Jay Tibbs (4-0) L: Brian Holman (2-4) S: Gregg Olson (10) | First | -- |
| Thursday, June 22 |
| » Defeated Angels (39-30), 6-5 | Anaheim Stadium (2-1) | 41-28 | Won 7 |
| » W: Mark Williamson (5-2) L: Willie Fraser (1-4) S: Gregg Olson (11) | First | -- |
| Friday, June 23 |
| » Lost to Angels (40-30), 5-1 | Anaheim Stadium (2-2) | 41-29 | |
| » W: Mike Witt (5-7) L: Dave Schmidt (7-6) | First | -- |
| Saturday, June 24 |
| » Lost to Angels (41-30), 8-3 | Anaheim Stadium (2-3) | 41-30 | Lost 2 |
| » W: Chuck Finley (8-6) L: Bob Milacki (4-7) | First | -- |
| Sunday, June 25 |
| » Lost to Angels (42-30), 7-6 | Anaheim Stadium (2-4) | 41-31 | Lost 3 |
| » W: Kirk McCaskill (8-4) L: Jeff Ballard (9-3) S: Bryan Harvey (9) | First | -- |
| Tuesday, June 27 |
| » Defeated Blue Jays (36-39), 16-6 | Memorial Stadium (21-16) | 42-31 | |
| » W: Jay Tibbs (5-0) L: Mike Flanagan (4-6) | First | -- |
| Wednesday, June 28 |
| » Defeated Blue Jays (36-40), 2-1 | Memorial Stadium (22-16) | 43-31 | Won 2 |
| » W: Kevin Hickey (2-2) L: John Cerutti (3-4) S: Gregg Olson (12) | First | -- |
| Thursday, June 29 |
| » Lost to Blue Jays (37-40), 11-1 | Memorial Stadium (22-17) | 43-32 | |
| » W: Steve Cummings (1-0) L: Dave Schmidt (7-7) | First | -- |
| Friday, June 30 |
| » Lost to Tigers (30-46), 16-5 | Memorial Stadium (22-18) | 43-33 | Lost 2 |
| » W: Mike Schwabe (2-3) L: Bob Milacki (4-8) | First | -- |
| » Major-league debuts: Mike Smith (Orioles) |
| Saturday, July 1 |
| » Defeated Tigers (30-47), 8-1 | Memorial Stadium (23-18) | 44-33 | |
| » W: Jeff Ballard (10-3) L: Charles Hudson (0-4) | First | -- |
| Sunday, July 2 |
| » Lost to Tigers (31-47), 7-3 | Memorial Stadium (23-19) | 44-34 | |
| » W: Edwin Nunez (1-1) L: Mark Thurmond (2-2) S: Mike Henneman (2) | First | -- |
| Monday, July 3 |
| » Defeated Tigers (31-48), 11-4 | Memorial Stadium (24-19) | 45-34 | |
| » W: Mike Smith (1-0) L: Doyle Alexander (4-8) | First | -- |
| Tuesday, July 4 |
| » Defeated Blue Jays (38-44), 8-0 | Skydome (1-0) | 46-34 | Won 2 |
| » W: Dave Schmidt (8-7) L: Dave Stieb (7-5) S: Mark Williamson (7) | First | -- |
| Wednesday, July 5 |
| » Defeated Blue Jays (38-45), 5-4 | Skydome (2-0) | 47-34 | Won 3 |
| » W: Bob Milacki (5-8) L: Jimmy Key (7-8) S: Gregg Olson (13) | First | -- |
| Thursday, July 6 |
| » Lost to Blue Jays (39-45), 4-1 | Skydome (2-1) | 47-35 | |
| » W: Todd Stottlemyre (1-4) L: Jeff Ballard (10-4) S: Duane Ward (7) | First | -- |
| Friday, July 7 |
| » Lost to Brewers (41-44), 6-4 | County Stadium (0-1) | 47-36 | Lost 2 |
| » W: Don August (9-7) L: Pete Harnisch (0-2) S: Dan Plesac (22) | First | -- |
| Saturday, July 8 |
| » Defeated Brewers (41-45), 5-2 | County Stadium (1-1) | 48-36 | |
| » W: Brian Holton (3-5) L: Teddy Higuera (3-3) S: Gregg Olson (14) | First | -- |
| Sunday, July 9 |
| » Lost to Brewers (42-45), 7-2 | County Stadium (1-2) | 48-37 | |
| » W: Chris Bosio (9-5) L: Dave Schmidt (8-8) | First | -- |
| Thursday, July 13 |
| » Lost to Angels (53-33), 13-5 | Memorial Stadium (24-20) | 48-38 | Lost 2 |
| » W: Bert Blyleven (9-2) L: Mark Thurmond (2-3) | First | -- |
| Friday, July 14 |
| » Defeated Angels (53-34), 6-4 | Memorial Stadium (25-20) | 49-38 | |
| » W: Brian Holton (4-5) L: Kirk McCaskill (9-6) S: Gregg Olson (15) | First | -- |
| Saturday, July 15 |
| » Defeated Angels (53-35), 11-9 | Memorial Stadium (26-20) | 50-38 | Won 2 |
| » W: Mark Williamson (6-2) L: Bryan Harvey (1-2) | First | -- |
| Sunday, July 16 |
| » Defeated Angels (53-36), 3-2 | Memorial Stadium (27-20) | 51-38 | Won 3 |
| » W: Mike Smith (2-0) L: Willie Fraser (2-5) | First | -- |
| Monday, July 17 |
| » Defeated Mariners (45-46), 8-4 | Memorial Stadium (28-20) | 52-38 | Won 4 |
| » W: Pete Harnisch (1-2) L: Mike Dunne (2-5) | First | -- |
| Tuesday, July 18 |
| » Defeated Mariners (45-47), 4-3 | Memorial Stadium (29-20) | 53-38 | Won 5 |
| » W: Jeff Ballard (11-4) L: Randy Johnson (3-6) S: Gregg Olson (16) | First | -- |
| Wednesday, July 19 |
| » Lost to Mariners (46-47), 7-0 | Memorial Stadium (29-21) | 53-39 | |
| » W: Brian Holman (5-4) L: Brian Holton (4-6) | First | -- |
| Thursday, July 20 |
| » Lost to Athletics (56-39), 5-2 | Oakland-Alameda County Stadium (1-2) | 53-40 | Lost 2 |
| » W: Dave Stewart (14-5) L: Dave Schmidt (8-9) S: Dennis Eckersley (15) | First | -- |
| Friday, July 21 |
| » Lost to Athletics (57-39), 3-2 | Oakland-Alameda County Stadium (1-3) | 53-41 | Lost 3 |
| » W: Mike Moore (13-5) L: Gregg Olson (3-1) | First | -- |
| Saturday, July 22 |
| » Lost to Athletics (58-39), 3-1 | Oakland-Alameda County Stadium (1-4) | 53-42 | Lost 4 |
| » W: Bob Welch (11-5) L: Pete Harnisch (1-3) S: Dennis Eckersley (16) | First | -- |
| Sunday, July 23 |
| » Lost to Athletics (59-39), 3-2 | Oakland-Alameda County Stadium (1-5) | 53-43 | Lost 5 |
| » W: Storm Davis (9-4) L: Jeff Ballard (11-5) S: Dennis Eckersley (17) | First | -- |
| Tuesday, July 25 |
| » Lost to Twins (47-51), 9-3 | Hubert H. Humphrey Metrodome (1-3) | 53-44 | Lost 6 |
| » W: Allan Anderson (10-9) L: Dave Schmidt (8-10) | First | -- |
| » Major-league debuts: Mark Guthrie (Twins) |
| Wednesday, July 26 |
| » Lost to Twins (48-51), 5-4 | Hubert H. Humphrey Metrodome (1-4) | 53-45 | Lost 7 |
| » W: Jeff Reardon (3-2) L: Mark Williamson (6-3) | First | -- |
| Thursday, July 27 |
| » Lost to Twins (49-51), 10-6 | Hubert H. Humphrey Metrodome (1-5) | 53-46 | Lost 8 |
| » W: Roy Smith (6-4) L: Pete Harnisch (1-4) | First | -- |
| Friday, July 28 |
| » Defeated Royals (55-47), 4-3 | Royals Stadium (2-2) | 54-46 | |
| » W: Mark Williamson (7-3) L: Jeff Montgomery (7-2) | First | -- |
| Saturday, July 29 |
| » Lost to Royals (56-47), 5-0 | Royals Stadium (2-3) | 54-47 | |
| » W: Luis Aquino (6-4) L: Dave Schmidt (8-11) | First | -- |
| Sunday, July 30 |
| » Lost to Royals (57-47), 7-6 | Royals Stadium (2-4) | 54-48 | Lost 2 |
| » W: Steve Farr (1-4) L: Gregg Olson (3-2) S: Jeff Montgomery (6) | First | -- |
| Monday, July 31 |
| » Lost to Red Sox (50-51), 9-6 | Fenway Park (1-3) | 54-49 | Lost 3 |
| » W: Bob Stanley (3-2) L: Bob Milacki (5-9) S: Lee Smith (14) | First | -- |
| Tuesday, August 1 |
| » Lost to Red Sox (51-51), 5-3 | Fenway Park (1-4) | 54-50 | Lost 4 |
| » W: Rob Murphy (2-5) L: Pete Harnisch (1-5) S: Lee Smith (15) | First | -- |
| » Lost to Red Sox (52-51), 6-2 | Fenway Park (1-5) | 54-51 | Lost 5 |
| » W: Wes Gardner (3-6) L: Dave Johnson (0-1) | First | -- |
| Wednesday, August 2 |
| » Defeated Red Sox (52-52), 9-8 | Fenway Park (2-5) | 55-51 | |
| » W: Mark Williamson (8-3) L: Eric Hetzel (1-2) S: Mark Thurmond (3) | First | -- |
| Thursday, August 3 |
| » Major-league debuts: Russ Swan (Giants) |
| Friday, August 4 |
| » Lost to Rangers (58-49), 6-4 | Memorial Stadium (29-22) | 55-52 | |
| » W: Charlie Hough (6-11) L: Dave Schmidt (8-12) S: Jeff Russell (23) | First | -- |
| Saturday, August 5 |
| » Defeated Rangers (58-50), 5-2 | Memorial Stadium (30-22) | 56-52 | |
| » W: Bob Milacki (6-9) L: Nolan Ryan (12-7) S: Gregg Olson (17) | First | -- |
| Sunday, August 6 |
| » Defeated Rangers (58-51), 3-2 | Memorial Stadium (31-22) | 57-52 | Won 2 |
| » W: Mark Williamson (9-3) L: Jeff Russell (5-3) | First | -- |
| Monday, August 7 |
| » Lost to Twins (56-56), 4-2 | Memorial Stadium (31-23) | 57-53 | |
| » W: Roy Smith (7-4) L: Jeff Ballard (11-6) S: Jeff Reardon (20) | First | -- |
| Tuesday, August 8 |
| » Defeated Twins (56-57), 6-1 | Memorial Stadium (32-23) | 58-53 | |
| » W: Dave Johnson (1-1) L: Rick Aguilera (6-8) | First | -- |
| Wednesday, August 9 |
| » Lost to Twins (57-57), 7-0 | Memorial Stadium (32-24) | 58-54 | |
| » W: Allan Anderson (13-9) L: Mark Thurmond (2-4) | First | -- |
| Friday, August 11 |
| » Lost to Red Sox (56-56), 6-4 | Memorial Stadium (32-25) | 58-55 | Lost 2 |
| » W: Roger Clemens (12-8) L: Bob Milacki (6-10) | First | -- |
| » Defeated Red Sox (56-57), 4-1 | Memorial Stadium (33-25) | 59-55 | |
| » W: Pete Harnisch (2-5) L: Mike Smithson (6-10) | First | -- |
| Saturday, August 12 |
| » Lost to Red Sox (57-57), 10-8 | Memorial Stadium (33-26) | 59-56 | |
| » W: Bob Stanley (4-2) L: Kevin Hickey (2-3) | First | -- |
| Sunday, August 13 |
| » Defeated Red Sox (57-58), 6-1 | Memorial Stadium (34-26) | 60-56 | |
| » W: Dave Johnson (2-1) L: Tom Bolton (0-3) | First | -- |
| Monday, August 14 |
| » Defeated Tigers (43-75), 4-1 | Tiger Stadium (5-0) | 61-56 | Won 2 |
| » W: Dave Schmidt (9-12) L: Jack Morris (2-10) S: Gregg Olson (18) | First | -- |
| Tuesday, August 15 |
| » Defeated Tigers (43-76), 2-0 | Tiger Stadium (6-0) | 62-56 | Won 3 |
| » W: Bob Milacki (7-10) L: Doyle Alexander (5-14) | First | -- |
| Wednesday, August 16 |
| » Lost to Tigers (44-76), 4-0 | Tiger Stadium (6-1) | 62-57 | |
| » W: Frank Tanana (9-10) L: Pete Harnisch (2-6) | First | -- |
| Thursday, August 17 |
| » Defeated Blue Jays (61-60), 11-6 | Memorial Stadium (35-26) | 63-57 | |
| » W: Jeff Ballard (12-6) L: John Cerutti (9-7) | First | -- |
| Friday, August 18 |
| » Lost to Blue Jays (62-60), 9-2 | Memorial Stadium (35-27) | 63-58 | |
| » W: Mauro Gozzo (3-0) L: Dave Johnson (2-2) | First | -- |
| Saturday, August 19 |
| » Lost to Blue Jays (63-60), 5-1 | Memorial Stadium (35-28) | 63-59 | Lost 2 |
| » W: Jimmy Key (8-13) L: Bob Milacki (7-11) | First | -- |
| Sunday, August 20 |
| » Defeated Blue Jays (63-61), 7-2 | Memorial Stadium (36-28) | 64-59 | |
| » W: Pete Harnisch (3-6) L: Dave Stieb (12-8) S: Mark Thurmond (4) | First | -- |
| Monday, August 21 |
| » Defeated Brewers (65-62), 5-0 | Memorial Stadium (37-28) | 65-59 | Won 2 |
| » W: Jeff Ballard (13-6) L: Jerry Reuss (8-7) | First | -- |
| Tuesday, August 22 |
| » Defeated Brewers (65-63), 4-2 | Memorial Stadium (38-28) | 66-59 | Won 3 |
| » W: Dave Johnson (3-2) L: Chris Bosio (14-8) | First | -- |
| Wednesday, August 23 |
| » Defeated Brewers (65-64), 3-1 | Memorial Stadium (39-28) | 67-59 | Won 4 |
| » W: Bob Milacki (8-11) L: Tom Filer (4-2) S: Gregg Olson (19) | First | -- |
| Thursday, August 24 |
| » Lost to Yankees (58-70), 5-1 | Yankee Stadium (1-2) | 67-60 | |
| » W: Chuck Cary (3-2) L: Pete Harnisch (3-7) | First | -- |
| » Defeated Yankees (58-71), 9-2 | Yankee Stadium (2-2) | 68-60 | |
| » W: Dave Schmidt (10-12) L: Eric Plunk (4-4) | First | -- |
| Friday, August 25 |
| » Defeated Yankees (58-72), 3-1 | Yankee Stadium (3-2) | 69-60 | Won 2 |
| » W: Jeff Ballard (14-6) L: Clay Parker (3-4) S: Gregg Olson (20) | First | -- |
| Former Oriole Jim Brideweser dies in ElToro, CA at the age of 63. |
| Saturday, August 26 |
| » Defeated Yankees (58-73), 6-4 | Yankee Stadium (4-2) | 70-60 | Won 3 |
| » W: Dave Johnson (4-2) L: Walt Terrell (7-17) S: Gregg Olson (21) | First | -- |
| Sunday, August 27 |
| » Defeated Yankees (58-74), 8-5 | Yankee Stadium (5-2) | 71-60 | Won 4 |
| » W: Bob Milacki (9-11) L: Greg Cadaret (4-4) | First | -- |
| Tuesday, August 29 |
| » Lost to Indians (62-69), 3-1 | Cleveland Stadium (2-2) | 71-61 | |
| » W: Doug Jones (6-7) L: Pete Harnisch (3-8) | First | -- |
| Wednesday, August 30 |
| » Defeated Indians (62-70), 7-4 | Cleveland Stadium (3-2) | 72-61 | |
| » W: Jeff Ballard (15-6) L: Greg Swindell (13-4) S: Gregg Olson (22) | First | -- |
| Thursday, August 31 |
| » Lost to Indians (63-70), 11-0 | Cleveland Stadium (3-3) | 72-62 | |
| » W: John Farrell (8-13) L: Dave Johnson (4-3) | First | -- |
| Friday, September 1 |
| » Lost to White Sox (57-77), 10-1 | Comiskey Park I (3-1) | 72-63 | Lost 2 |
| » W: Eric King (7-8) L: Bob Milacki (9-12) | Second | 1 out |
| Saturday, September 2 |
| » Defeated White Sox (57-78), 2-1 | Comiskey Park I (4-1) | 73-63 | |
| » W: Brian Holton (5-6) L: Greg Hibbard (4-6) S: Gregg Olson (23) | Second | 1 out |
| Sunday, September 3 |
| » Lost to White Sox (58-78), 4-2 | Comiskey Park I (4-2) | 73-64 | |
| » W: Melido Perez (8-13) L: Jeff Ballard (15-7) S: Bobby Thigpen (29) | Second | 1 out |
| Monday, September 4 |
| » Defeated Indians (63-74), 5-4 | Memorial Stadium (40-28) | 74-64 | |
| » W: Mark Williamson (10-3) L: Rod Nichols (3-4) | Second | 1 out |
| Tuesday, September 5 |
| » Defeated Indians (63-75), 3-1 | Memorial Stadium (41-28) | 75-64 | Won 2 |
| » W: Bob Milacki (10-12) L: John Farrell (8-14) S: Gregg Olson (24) | Second | 1 out |
| Wednesday, September 6 |
| » Lost to Indians (64-75), 9-0 | Memorial Stadium (41-29) | 75-65 | |
| » W: Bud Black (10-11) L: Curt Schilling (0-1) | Second | 2 out |
| » Major-league debuts: Juan Bell and Ben McDonald (Orioles) |
| Thursday, September 7 |
| » Defeated Rangers (71-67), 8-3 | Arlington Stadium (2-0) | 76-65 | |
| » W: Jeff Ballard (16-7) L: Nolan Ryan (15-10) S: Mark Williamson (8) | Second | 1½ out |
| » Defeated Rangers (71-68), 9-6 | Arlington Stadium (3-0) | 77-65 | Won 2 |
| » W: Pete Harnisch (4-8) L: Bobby Witt (10-13) | Second | 1½ out |
| » Major-league debuts: John Barfield (Rangers) |
| Friday, September 8 |
| » Lost to Rangers (72-68), 3-1 | Arlington Stadium (3-1) | 77-66 | |
| » W: Kevin Brown (12-9) L: Dave Johnson (4-4) S: Jeff Russell (34) | Second | 1½ out |
| Saturday, September 9 |
| » Defeated Rangers (72-69), 4-2 | Arlington Stadium (4-1) | 78-66 | |
| » W: Gregg Olson (4-2) L: Drew Hall (1-1) | Second | 1½ out |
| Sunday, September 10 |
| » Lost to Rangers (73-69), 8-1 | Arlington Stadium (4-2) | 78-67 | |
| » W: Jamie Moyer (4-6) L: Dave Schmidt (10-13) | Second | 2½ out |
| Monday, September 11 |
| » Defeated White Sox (59-84), 6-3 | Memorial Stadium (42-29) | 79-67 | |
| » W: Jeff Ballard (17-7) L: Steve Rosenberg (4-12) S: Gregg Olson (25) | Second | 2 out |
| » Major-league debuts: Wayne Edwards (White Sox) |
| Tuesday, September 12 |
| » Lost to White Sox (60-84), 11-1 | Memorial Stadium (42-30) | 79-68 | |
| » W: Eric King (8-9) L: Pete Harnisch (4-9) | Second | 2 out |
| » Major-league debuts: Robin Ventura (White Sox) |
| Wednesday, September 13 |
| » Lost to White Sox (61-84), 3-0 | Memorial Stadium (42-31) | 79-69 | Lost 2 |
| » W: Greg Hibbard (5-7) L: Dave Johnson (4-5) S: Bobby Thigpen (30) | Second | 2 out |
| Friday, September 15 |
| » Defeated Royals (85-62), 5-2 | Memorial Stadium (43-31) | 80-69 | |
| » W: Bob Milacki (11-12) L: Steve Crawford (3-1) S: Gregg Olson (26) | Second | 1½ out |
| Saturday, September 16 |
| » Defeated Royals (85-63), 7-5 | Memorial Stadium (44-31) |