| Monday, April 3 |
| » Lost to Athletics (1-0), 3-2 | Oakland-Alameda County Stadium (0-1) | 0-1 | |
| » W: Dave Stewart (1-0) L: Mark Langston (0-1) S: Dennis Eckersley (1) | Third | 1 out |
| » Major-league debuts: Omar Vizquel (Mariners) |
| Wednesday, April 5 |
| » Lost to Athletics (2-0), 11-1 | Oakland-Alameda County Stadium (0-2) | 0-2 | Lost 2 |
| » W: Bob Welch (1-0) L: Scott Bankhead (0-1) | Fourth | 2 out |
| Thursday, April 6 |
| » Lost to Athletics (3-0), 11-3 | Oakland-Alameda County Stadium (0-3) | 0-3 | Lost 3 |
| » W: Storm Davis (1-0) L: Mike Campbell (0-1) S: Todd Burns (1) | Fifth | 3 out |
| Friday, April 7 |
| » Lost to Angels (2-2), 2-1 | Anaheim Stadium (0-1) | 0-4 | Lost 4 |
| » W: Kirk McCaskill (1-0) L: Erik Hanson (0-1) S: Bryan Harvey (1) | Fourth | 3 out |
| Saturday, April 8 |
| » Defeated Angels (2-3), 7-0 | Anaheim Stadium (1-1) | 1-4 | |
| » W: Mark Langston (1-1) L: Jim Abbott (0-1) | Fifth | 3 out |
| » Major-league debuts: Jim Abbott (Angels) |
| Sunday, April 9 |
| » Lost to Angels (3-3), 13-5 | Anaheim Stadium (1-2) | 1-5 | |
| » W: Mike Witt (1-1) L: Steve Trout (0-1) | Fourth | 3½ out |
| Monday, April 10 |
| » Defeated White Sox (4-3), 6-5 | Kingdome (1-0) | 2-5 | |
| » W: Jerry Reed (1-0) L: Eric King (0-2) S: Mike Schooler (1) | Sixth | 3½ out |
| Tuesday, April 11 |
| » Lost to White Sox (5-3), 8-6 | Kingdome (1-1) | 2-6 | |
| » W: Barry Jones (1-0) L: Tom Niedenfuer (0-1) S: Bobby Thigpen (2) | Sixth | 4 out |
| Wednesday, April 12 |
| » Defeated White Sox (5-4), 9-1 | Kingdome (2-1) | 3-6 | |
| » W: Erik Hanson (1-1) L: Bill Long (1-1) | Fifth | 4 out |
| » Major-league debuts: Matt Merullo (White Sox) |
| Friday, April 14 |
| » Defeated Angels (5-6), 9-5 | Kingdome (3-1) | 4-6 | Won 2 |
| » W: Mark Langston (2-1) L: Mike Witt (1-2) | Seventh | 4½ out |
| Saturday, April 15 |
| » Lost to Angels (6-6), 9-2 | Kingdome (3-2) | 4-7 | |
| » W: Chuck Finley (2-1) L: Jerry Reed (1-1) | Seventh | 5½ out |
| » Major-league debuts: Kent Anderson (Angels) |
| Sunday, April 16 |
| » Lost to Angels (7-6), 10-0 | Kingdome (3-3) | 4-8 | Lost 2 |
| » W: Bert Blyleven (2-0) L: Mike Campbell (0-2) | Seventh | 6½ out |
| Monday, April 17 |
| » Defeated Athletics (8-6), 7-2 | Kingdome (4-3) | 5-8 | |
| » W: Erik Hanson (2-1) L: Curt Young (0-3) | Sixth | 5½ out |
| Tuesday, April 18 |
| » Lost to Athletics (9-6), 5-3 | Kingdome (4-4) | 5-9 | |
| » W: Eric Plunk (1-0) L: Jerry Reed (1-2) S: Dennis Eckersley (3) | Seventh | 6½ out |
| Wednesday, April 19 |
| » Lost to Athletics (10-6), 7-5 | Kingdome (4-5) | 5-10 | Lost 2 |
| » W: Dave Stewart (4-0) L: Mark Langston (2-2) S: Dennis Eckersley (4) | Seventh | 7½ out |
| Thursday, April 20 |
| » Defeated White Sox (6-9), 5-2 | Comiskey Park I (1-0) | 6-10 | |
| » W: Scott Bankhead (1-1) L: Barry Jones (1-1) | Seventh | 7 out |
| Friday, April 21 |
| » Defeated White Sox (6-10), 11-1 | Comiskey Park I (2-0) | 7-10 | Won 2 |
| » W: Mike Campbell (1-2) L: Jerry Reuss (2-2) | Fifth | 6 out |
| Saturday, April 22 |
| » Lost to White Sox (7-10), 1-0 | Comiskey Park I (2-1) | 7-11 | |
| » W: Eric King (1-3) L: Erik Hanson (2-2) | Seventh | 6 out |
| Sunday, April 23 |
| » Defeated White Sox (7-11), 10-6 | Comiskey Park I (3-1) | 8-11 | |
| » W: Steve Trout (1-1) L: Shawn Hillegas (0-2) | Sixth | 6 out |
| Monday, April 24 |
| » Lost to Tigers (6-10), 1-0 | Tiger Stadium (0-1) | 8-12 | |
| » W: Doyle Alexander (3-0) L: Mark Langston (2-3) | Sixth | 6½ out |
| Tuesday, April 25 |
| » Lost to Tigers (7-10), 5-2 | Tiger Stadium (0-2) | 8-13 | Lost 2 |
| » W: Frank Tanana (1-3) L: Scott Bankhead (1-2) S: Willie Hernandez (4) | Sixth | 7½ out |
| Wednesday, April 26 |
| » Defeated Blue Jays (8-13), 7-6 | Kingdome (5-5) | 9-13 | |
| » W: Steve Trout (2-1) L: David Wells (1-1) S: Mike Jackson (1) | Sixth | 7½ out |
| Thursday, April 27 |
| » Lost to Blue Jays (9-13), 6-1 | Kingdome (5-6) | 9-14 | |
| » W: Mike Flanagan (1-1) L: Mike Dunne (1-2) | Sixth | 8 out |
| Friday, April 28 |
| » Defeated Orioles (11-11), 11-5 | Kingdome (6-6) | 10-14 | |
| » W: Jerry Reed (2-2) L: Brian Holton (1-3) | Sixth | 7½ out |
| Saturday, April 29 |
| » Defeated Orioles (11-12), 4-3 | Kingdome (7-6) | 11-14 | Won 2 |
| » W: Mark Langston (3-3) L: Dave Schmidt (1-3) S: Mike Schooler (2) | Fifth | 7 out |
| Sunday, April 30 |
| » Lost to Orioles (12-12), 4-3 | Kingdome (7-7) | 11-15 | |
| » W: Jeff Ballard (5-0) L: Steve Trout (2-2) S: Mark Williamson (4) | Sixth | 8 out |
| Monday, May 1 |
| » Defeated Tigers (8-15), 5-3 | Kingdome (8-7) | 12-15 | |
| » W: Dennis Powell (1-0) L: Jack Morris (0-6) S: Mike Schooler (3) | Fifth | 7 out |
| Tuesday, May 2 |
| » Defeated Tigers (8-16), 7-2 | Kingdome (9-7) | 13-15 | Won 2 |
| » W: Mike Dunne (2-2) L: Charles Hudson (0-2) S: Mike Jackson (2) | Fifth | 6 out |
| Wednesday, May 3 |
| » Defeated Tigers (8-17), 3-2 | Kingdome (10-7) | 14-15 | Won 3 |
| » W: Erik Hanson (3-2) L: Doyle Alexander (3-2) S: Mike Schooler (4) | Fifth | 6 out |
| Saturday, May 6 |
| » Defeated Orioles (13-14), 2-1 | Memorial Stadium (1-0) | 15-15 | Won 4 |
| » W: Mark Langston (4-3) L: Dave Schmidt (1-4) S: Mike Schooler (5) | Fifth | 4½ out |
| » Defeated Orioles (13-15), 6-5 | Memorial Stadium (2-0) | 16-15 | Won 5 |
| » W: Scott Bankhead (2-2) L: Jeff Ballard (5-1) S: Mike Schooler (6) | Fifth | 4½ out |
| Sunday, May 7 |
| » Defeated Orioles (13-16), 5-3 | Memorial Stadium (3-0) | 17-15 | Won 6 |
| » W: Bill Swift (1-0) L: Jose Bautista (2-3) S: Dennis Powell (1) | Fifth | 4½ out |
| Monday, May 8 |
| » Lost to Blue Jays (11-20), 10-1 | Exhibition Stadium (0-1) | 17-16 | |
| » W: Dave Stieb (3-0) L: Mike Dunne (2-3) | Fifth | 5½ out |
| Tuesday, May 9 |
| » Defeated Blue Jays (11-21), 4-3 | Exhibition Stadium (1-1) | 18-16 | |
| » W: Erik Hanson (4-2) L: Mike Flanagan (2-2) S: Mike Schooler (7) | Fourth | 5 out |
| Wednesday, May 10 |
| » Lost to Blue Jays (12-21), 3-2 | Exhibition Stadium (1-2) | 18-17 | |
| » W: Jimmy Key (3-2) L: Mark Langston (4-4) | Fifth | 5½ out |
| Friday, May 12 |
| » Lost to Red Sox (17-15), 2-0 | Kingdome (10-8) | 18-18 | Lost 2 |
| » W: Roger Clemens (5-1) L: Scott Bankhead (2-3) | Fourth | 6 out |
| Saturday, May 13 |
| » Defeated Red Sox (17-16), 14-6 | Kingdome (11-8) | 19-18 | |
| » W: Jerry Reed (3-2) L: John Dopson (4-2) | Fourth | 6 out |
| Sunday, May 14 |
| » Defeated Red Sox (17-17), 4-3 | Kingdome (12-8) | 20-18 | Won 2 |
| » W: Steve Trout (3-2) L: Mike Boddicker (2-4) S: Mike Schooler (8) | Fourth | 5 out |
| Tuesday, May 16 |
| » Defeated Brewers (15-21), 6-5 | Kingdome (13-8) | 21-18 | Won 3 |
| » W: Mike Jackson (1-0) L: Bill Wegman (2-5) S: Mike Schooler (9) | Third | 4½ out |
| Wednesday, May 17 |
| » Lost to Brewers (16-21), 9-6 | Kingdome (13-9) | 21-19 | |
| » W: Chuck Crim (3-2) L: Scott Bankhead (2-4) S: Dan Plesac (7) | Fourth | 5½ out |
| Thursday, May 18 |
| » Defeated Brewers (16-22), 9-5 | Kingdome (14-9) | 22-19 | |
| » W: Bill Swift (2-0) L: Chris Bosio (5-3) S: Mike Schooler (10) | Fifth | 5½ out |
| Friday, May 19 |
| » Lost to Yankees (19-21), 9-5 | Kingdome (14-10) | 22-20 | |
| » W: Andy Hawkins (4-5) L: Erik Hanson (4-3) S: Lee Guetterman (6) | Fourth | 5½ out |
| Saturday, May 20 |
| » Defeated Yankees (19-22), 6-4 | Kingdome (15-10) | 23-20 | |
| » W: Steve Trout (4-2) L: Dave LaPoint (5-2) S: Mike Schooler (11) | Fifth | 5½ out |
| Sunday, May 21 |
| » Lost to Yankees (20-22), 6-2 | Kingdome (15-11) | 23-21 | |
| » W: Clay Parker (2-0) L: Mark Langston (4-5) | Fifth | 6½ out |
| Tuesday, May 23 |
| » Lost to Red Sox (20-21), 6-5 | Fenway Park (0-1) | 23-22 | Lost 2 |
| » W: Lee Smith (2-1) L: Jerry Reed (3-3) | Fifth | 6½ out |
| Wednesday, May 24 |
| » Lost to Red Sox (21-21), 6-5 | Fenway Park (0-2) | 23-23 | Lost 3 |
| » W: Mike Boddicker (3-4) L: Erik Hanson (4-4) S: Lee Smith (5) | Fifth | 7½ out |
| Thursday, May 25 |
| » Lost to Red Sox (22-21), 10-0 | Fenway Park (0-3) | 23-24 | Lost 4 |
| » W: Mike Smithson (2-3) L: Mike Dunne (2-4) | Fifth | 7½ out |
| Friday, May 26 |
| » Defeated Brewers (19-26), 7-2 | County Stadium (1-0) | 24-24 | |
| » W: Mike Jackson (2-0) L: Don August (3-6) | Fifth | 7½ out |
| Saturday, May 27 |
| » Lost to Brewers (20-26), 3-2 | County Stadium (1-1) | 24-25 | |
| » W: Dan Plesac (2-2) L: Brian Holman (1-3) | Fifth | 8½ out |
| Sunday, May 28 |
| » Lost to Brewers (21-26), 6-4 | County Stadium (1-2) | 24-26 | Lost 2 |
| » W: Chuck Crim (4-2) L: Dennis Powell (1-1) S: Dan Plesac (10) | Fifth | 9½ out |
| Monday, May 29 |
| » Lost to Yankees (22-26), 6-3 | Yankee Stadium (0-1) | 24-27 | Lost 3 |
| » W: Richard Dotson (2-2) L: Dennis Powell (1-2) S: Dave Righetti (8) | Fifth | 9½ out |
| Tuesday, May 30 |
| » Defeated Yankees (22-27), 3-2 | Yankee Stadium (1-1) | 25-27 | |
| » W: Randy Johnson (1-4) L: Jimmy Jones (0-1) S: Mike Schooler (12) | Fifth | 9½ out |
| Wednesday, May 31 |
| » Lost to Yankees (23-27), 9-5 | Yankee Stadium (1-2) | 25-28 | |
| » W: Andy Hawkins (5-6) L: Steve Trout (4-3) S: Lee Guetterman (7) | Fifth | 9½ out |
| » Major-league debuts: Deion Sanders (Yankees) |
| Thursday, June 1 |
| » Defeated Rangers (27-23), 3-2 | Kingdome (16-11) | 26-28 | |
| » W: Mike Schooler (1-0) L: Kevin Brown (4-2) | Fifth | 9 out |
| Friday, June 2 |
| » Lost to Rangers (28-23), 9-5 | Kingdome (16-12) | 26-29 | |
| » W: Mike Jeffcoat (1-0) L: Bill Swift (2-1) S: Cecilio Guante (3) | Fifth | 9 out |
| Saturday, June 3 |
| » Lost to Rangers (29-23), 6-1 | Kingdome (16-13) | 26-30 | Lost 2 |
| » W: Nolan Ryan (6-3) L: Clint Zavaras (0-1) | Sixth | 10 out |
| » Major-league debuts: Clint Zavaras (Mariners) |
| Sunday, June 4 |
| » Defeated Rangers (29-24), 2-1 | Kingdome (17-13) | 27-30 | |
| » W: Randy Johnson (2-4) L: Charlie Hough (3-6) S: Mike Schooler (13) | Fifth | 10 out |
| Monday, June 5 |
| » Lost to Royals (32-23), 5-3 | Kingdome (17-14) | 27-31 | |
| » W: Tom Gordon (6-2) L: Tom Niedenfuer (0-2) | Sixth | 10 out |
| Tuesday, June 6 |
| » Defeated Royals (32-24), 5-2 | Kingdome (18-14) | 28-31 | |
| » W: Scott Bankhead (3-4) L: Stan Clarke (0-2) | Fifth | 10 out |
| » Major-league debuts: Rick Luecken (Royals) |
| Wednesday, June 7 |
| » Lost to Royals (33-24), 9-6 | Kingdome (18-15) | 28-32 | |
| » W: Mark Gubicza (6-4) L: Bill Swift (2-2) S: Jeff Montgomery (1) | Fifth | 11 out |
| Friday, June 9 |
| » Lost to Indians (29-29), 5-4 | Cleveland Stadium (0-1) | 28-33 | Lost 2 |
| » W: Tom Candiotti (7-3) L: Clint Zavaras (0-2) S: Doug Jones (13) | Fifth | 11 out |
| Saturday, June 10 |
| » Defeated Indians (29-30), 3-1 | Cleveland Stadium (1-1) | 29-33 | |
| » W: Randy Johnson (3-4) L: John Farrell (3-7) S: Mike Schooler (14) | Fifth | 11 out |
| Sunday, June 11 |
| » Defeated Indians (29-31), 6-3 | Cleveland Stadium (2-1) | 30-33 | Won 2 |
| » W: Brian Holman (2-3) L: Bud Black (5-7) S: Gene Harris (1) | Fifth | 11 out |
| Tuesday, June 13 |
| » Lost to Twins (29-32), 4-3 | Hubert H. Humphrey Metrodome (0-1) | 30-34 | |
| » W: Gary Wayne (1-0) L: Jerry Reed (3-4) | Sixth | 10½ out |
| Wednesday, June 14 |
| » Lost to Twins (30-32), 10-8 | Hubert H. Humphrey Metrodome (0-2) | 30-35 | Lost 2 |
| » W: Juan Berenguer (4-2) L: Tom Niedenfuer (0-3) S: Jeff Reardon (12) | Sixth | 11½ out |
| Thursday, June 15 |
| » Defeated Twins (30-33), 9-5 | Hubert H. Humphrey Metrodome (1-2) | 31-35 | |
| » W: Dennis Powell (2-2) L: Steve Shields (0-1) S: Mike Jackson (3) | Sixth | 11 out |
| Friday, June 16 |
| » Lost to Blue Jays (30-35), 4-3 | Skydome (0-1) | 31-36 | |
| » W: Tom Henke (5-3) L: Mike Schooler (1-1) | Sixth | 11½ out |
| Saturday, June 17 |
| » Lost to Blue Jays (31-35), 3-2 | Skydome (0-2) | 31-37 | Lost 2 |
| » W: Duane Ward (4-7) L: Mike Jackson (2-1) | Sixth | 11½ out |
| Sunday, June 18 |
| » Defeated Blue Jays (31-36), 8-2 | Skydome (1-2) | 32-37 | |
| » W: Scott Bankhead (4-4) L: Frank Wills (0-1) | Sixth | 10½ out |
| Monday, June 19 |
| » Lost to Orioles (38-28), 9-5 | Kingdome (18-16) | 32-38 | |
| » W: Bob Milacki (4-6) L: Mike Jackson (2-2) S: Mark Thurmond (2) | Sixth | 10½ out |
| Tuesday, June 20 |
| » Lost to Orioles (39-28), 8-6 | Kingdome (18-17) | 32-39 | Lost 2 |
| » W: Mickey Weston (1-0) L: Jerry Reed (3-5) S: Gregg Olson (9) | Sixth | 11½ out |
| Wednesday, June 21 |
| » Lost to Orioles (40-28), 8-6 | Kingdome (18-18) | 32-40 | Lost 3 |
| » W: Jay Tibbs (4-0) L: Brian Holman (2-4) S: Gregg Olson (10) | Sixth | 12½ out |
| Friday, June 23 |
| » Lost to Tigers (27-43), 5-4 | Kingdome (18-19) | 32-41 | Lost 4 |
| » W: Mike Henneman (4-1) L: Mike Schooler (1-2) | Sixth | 12 out |
| Former Mariner Rick Anderson dies in Wilmington, CA at the age of 36. |
| Saturday, June 24 |
| » Defeated Tigers (27-44), 3-1 | Kingdome (19-19) | 33-41 | |
| » W: Scott Bankhead (5-4) L: Frank Tanana (7-7) S: Mike Schooler (15) | Sixth | 12 out |
| Sunday, June 25 |
| » Defeated Tigers (27-45), 5-3 | Kingdome (20-19) | 34-41 | Won 2 |
| » W: Bill Swift (3-2) L: David Palmer (0-3) S: Mike Jackson (4) | Sixth | 12 out |
| Tuesday, June 27 |
| » Defeated Royals (42-32), 8-0 | Royals Stadium (1-0) | 35-41 | Won 3 |
| » W: Brian Holman (3-4) L: Luis Aquino (3-2) | Sixth | 10½ out |
| Wednesday, June 28 |
| » Lost to Royals (43-32), 12-7 | Royals Stadium (1-1) | 35-42 | |
| » W: Mark Gubicza (8-5) L: Gene Harris (1-2) | Sixth | 10½ out |
| Thursday, June 29 |
| » Defeated Rangers (43-34), 2-0 | Arlington Stadium (1-0) | 36-42 | |
| » W: Scott Bankhead (6-4) L: Charlie Hough (5-8) S: Mike Schooler (16) | Sixth | 10 out |
| Friday, June 30 |
| » Defeated Rangers (43-35), 4-3 | Arlington Stadium (2-0) | 37-42 | Won 2 |
| » W: Bill Swift (4-2) L: Nolan Ryan (9-4) S: Mike Schooler (17) | Sixth | 10 out |
| Saturday, July 1 |
| » Lost to Rangers (44-35), 1-0 | Arlington Stadium (2-1) | 37-43 | |
| » W: Bobby Witt (6-8) L: Randy Johnson (3-5) S: Jeff Russell (19) | Sixth | 11 out |
| Tuesday, July 4 |
| » Defeated Twins (41-41), 3-2 | Kingdome (21-19) | 38-43 | |
| » W: Scott Bankhead (7-4) L: Allan Anderson (9-6) S: Mike Schooler (18) | Sixth | 11 out |
| Wednesday, July 5 |
| » Defeated Twins (41-42), 7-3 | Kingdome (22-19) | 39-43 | Won 2 |
| » W: Gene Harris (2-2) L: Mike Dyer (0-2) S: Mike Schooler (19) | Sixth | 10½ out |
| Thursday, July 6 |
| » Defeated Twins (41-43), 7-5 | Kingdome (23-19) | 40-43 | Won 3 |
| » W: Mike Jackson (3-2) L: Gary Wayne (3-1) S: Mike Schooler (20) | Sixth | 10 out |
| Friday, July 7 |
| » Lost to Indians (40-43), 4-3 | Kingdome (23-20) | 40-44 | |
| » W: Doug Jones (3-3) L: Mike Jackson (3-3) | Sixth | 10½ out |
| Saturday, July 8 |
| » Defeated Indians (40-44), 4-3 | Kingdome (24-20) | 41-44 | |
| » W: Bill Swift (5-2) L: Jesse Orosco (0-2) | Fifth | 10½ out |
| Sunday, July 9 |
| » Defeated Indians (40-45), 8-0 | Kingdome (25-20) | 42-44 | Won 2 |
| » W: Scott Bankhead (8-4) L: Scott Bailes (4-4) | Fifth | 10½ out |
| Thursday, July 13 |
| » Defeated Tigers (31-55), 5-4 | Tiger Stadium (1-2) | 43-44 | Won 3 |
| » W: Bill Swift (6-2) L: Mike Schwabe (2-4) | Fifth | 10½ out |
| » Major-league debuts: Doug Strange (Tigers) |
| Friday, July 14 |
| » Defeated Tigers (31-56), 13-0 | Tiger Stadium (2-2) | 44-44 | Won 4 |
| » W: Brian Holman (4-4) L: Doyle Alexander (4-10) | Fifth | 9½ out |
| Saturday, July 15 |
| » Defeated Tigers (31-57), 9-3 | Tiger Stadium (3-2) | 45-44 | Won 5 |
| » W: Scott Bankhead (9-4) L: Kevin Ritz (0-1) | Fifth | 8½ out |
| » Major-league debuts: Kevin Ritz (Tigers) |
| Sunday, July 16 |
| » Lost to Tigers (32-57), 8-5 | Tiger Stadium (3-3) | 45-45 | |
| » W: Charles Hudson (1-4) L: Gene Harris (2-3) S: Edwin Nunez (1) | Fifth | 8½ out |
| Monday, July 17 |
| » Lost to Orioles (52-38), 8-4 | Memorial Stadium (3-1) | 45-46 | Lost 2 |
| » W: Pete Harnisch (1-2) L: Mike Dunne (2-5) | Fifth | 8 out |
| Tuesday, July 18 |
| » Lost to Orioles (53-38), 4-3 | Memorial Stadium (3-2) | 45-47 | Lost 3 |
| » W: Jeff Ballard (11-4) L: Randy Johnson (3-6) S: Gregg Olson (16) | Fifth | 9 out |
| Wednesday, July 19 |
| » Defeated Orioles (53-39), 7-0 | Memorial Stadium (4-2) | 46-47 | |
| » W: Brian Holman (5-4) L: Brian Holton (4-6) | Fifth | 8½ out |
| Thursday, July 20 |
| » Defeated Blue Jays (46-49), 5-2 | Kingdome (26-20) | 47-47 | Won 2 |
| » W: Scott Bankhead (10-4) L: Dave Stieb (9-6) S: Dennis Powell (2) | Fifth | 8½ out |
| Friday, July 21 |
| » Lost to Blue Jays (47-49), 8-1 | Kingdome (26-21) | 47-48 | |
| » W: Mike Flanagan (6-6) L: Gene Harris (2-4) | Fifth | 9½ out |
| Saturday, July 22 |
| » Lost to Blue Jays (48-49), 7-1 | Kingdome (26-22) | 47-49 | Lost 2 |
| » W: John Cerutti (6-5) L: Mike Dunne (2-6) S: Duane Ward (10) | Fifth | 10½ out |
| Sunday, July 23 |
| » Defeated Blue Jays (48-50), 5-2 | Kingdome (27-22) | 48-49 | |
| » W: Randy Johnson (4-6) L: Jimmy Key (7-11) | Fifth | 10½ out |
| Monday, July 24 |
| » Lost to White Sox (41-57), 5-4 | Comiskey Park I (3-2) | 48-50 | |
| » W: Shawn Hillegas (6-9) L: Mike Jackson (3-4) | Fourth | 11½ out |
| Tuesday, July 25 |
| » Lost to White Sox (42-57), 7-6 | Comiskey Park I (3-3) | 48-51 | Lost 2 |
| » W: Donn Pall (3-1) L: Mike Jackson (3-5) S: Bobby Thigpen (20) | Fourth | 12½ out |
| Wednesday, July 26 |
| » Lost to White Sox (43-57), 5-3 | Comiskey Park I (3-4) | 48-52 | Lost 3 |
| » W: Greg Hibbard (2-2) L: Bill Swift (6-3) S: Bobby Thigpen (21) | Fifth | 12½ out |
| Friday, July 28 |
| » Lost to Athletics (61-41), 8-7 | Oakland-Alameda County Stadium (0-4) | 48-53 | Lost 4 |
| » W: Todd Burns (6-2) L: Gene Harris (2-5) | Sixth | 14 out |
| Saturday, July 29 |
| » Defeated Athletics (61-42), 14-6 | Oakland-Alameda County Stadium (1-4) | 49-53 | |
| » W: Randy Johnson (5-6) L: Storm Davis (9-5) S: Bill Swift (1) | Sixth | 14 out |
| Sunday, July 30 |
| » Lost to Athletics (62-42), 5-3 | Oakland-Alameda County Stadium (1-5) | 49-54 | |
| » W: Dave Stewart (15-6) L: Brian Holman (5-5) S: Dennis Eckersley (18) | Sixth | 14 out |
| Monday, July 31 |
| » Defeated Angels (63-41), 6-5 | Kingdome (28-22) | 50-54 | |
| » W: Keith Comstock (1-0) L: Bryan Harvey (3-3) S: Mike Schooler (21) | Sixth | 13 out |
| Tuesday, August 1 |
| » Defeated Angels (63-42), 8-1 | Kingdome (29-22) | 51-54 | Won 2 |
| » W: Mike Dunne (3-6) L: Jim Abbott (9-7) | Sixth | 12½ out |
| Wednesday, August 2 |
| » Lost to Angels (64-42), 7-0 | Kingdome (29-23) | 51-55 | |
| » W: Bert Blyleven (11-2) L: Jerry Reed (3-6) | Sixth | 13½ out |
| Thursday, August 3 |
| » Lost to Angels (65-42), 6-0 | Kingdome (29-24) | 51-56 | Lost 2 |
| » W: Kirk McCaskill (11-6) L: Randy Johnson (5-7) | Sixth | 14 out |
| Friday, August 4 |
| » Lost to Athletics (66-43), 5-3 | Kingdome (29-25) | 51-57 | Lost 3 |
| » W: Dave Stewart (16-6) L: Brian Holman (5-6) S: Dennis Eckersley (20) | Sixth | 15 out |
| Saturday, August 5 |
| » Defeated Athletics (66-44), 11-5 | Kingdome (30-25) | 52-57 | |
| » W: Scott Bankhead (11-4) L: Mike Moore (14-6) S: Mike Jackson (5) | Sixth | 14 out |
| Sunday, August 6 |
| » Lost to Athletics (67-44), 2-1 | Kingdome (30-26) | 52-58 | |
| » W: Storm Davis (11-5) L: Mike Dunne (3-7) S: Dennis Eckersley (21) | Sixth | 15 out |
| Monday, August 7 |
| » Defeated Athletics (67-45), 5-1 | Kingdome (31-26) | 53-58 | |
| » W: Clint Zavaras (1-2) L: Bob Welch (11-7) | Sixth | 14½ out |
| Tuesday, August 8 |
| » Defeated Angels (67-44), 6-4 | Anaheim Stadium (2-2) | 54-58 | Won 2 |
| » W: Jerry Reed (4-6) L: Greg Minton (1-3) S: Mike Schooler (22) | Sixth | 13½ out |
| Wednesday, August 9 |
| » Lost to Angels (68-44), 4-1 | Anaheim Stadium (2-3) | 54-59 | |
| » W: Kirk McCaskill (12-6) L: Brian Holman (5-7) S: Bryan Harvey (16) | Sixth | 14½ out |
| Thursday, August 10 |
| » Defeated Angels (68-45), 3-2 | Anaheim Stadium (3-3) | 55-59 | |
| » W: Mike Jackson (4-5) L: Chuck Finley (13-8) S: Mike Schooler (23) | Sixth | 13½ out |
| Friday, August 11 |
| » Lost to White Sox (49-66), 9-6 | Kingdome (31-27) | 55-60 | |
| » W: Bobby Thigpen (2-4) L: Mike Schooler (1-3) | Sixth | 14½ out |
| Saturday, August 12 |
| » Defeated White Sox (49-67), 4-3 | Kingdome (32-27) | 56-60 | |
| » W: Jerry Reed (5-6) L: Donn Pall (4-4) | Sixth | 14½ out |
| Sunday, August 13 |
| » Lost to White Sox (50-67), 6-4 | Kingdome (32-28) | 56-61 | |
| » W: Bill Long (5-5) L: Keith Comstock (1-1) S: Bobby Thigpen (25) | Sixth | 14½ out |
| Tuesday, August 15 |
| » Defeated Rangers (61-56), 2-0 | Kingdome (33-28) | 57-61 | |
| » W: Brian Holman (6-7) L: Charlie Hough (7-12) S: Mike Schooler (24) | Sixth | 14½ out |
| Wednesday, August 16 |
| » Lost to Rangers (62-56), 3-1 | Kingdome (33-29) | 57-62 | |
| » W: Nolan Ryan (14-7) L: Scott Bankhead (11-5) S: Jeff Russell (26) | Sixth | 14½ out |
| Thursday, August 17 |
| » Lost to Royals (67-53), 4-2 | Kingdome (33-30) | 57-63 | Lost 2 |
| » W: Mark Gubicza (11-10) L: Mike Dunne (3-8) S: Jeff Montgomery (9) | Sixth | 15½ out |
| Friday, August 18 |
| » Lost to Royals (68-53), 3-1 | Kingdome (33-31) | 57-64 | Lost 3 |
| » W: Tom Gordon (15-4) L: Clint Zavaras (1-3) S: Jeff Montgomery (10) | Sixth | 15½ out |
| Saturday, August 19 |
| » Lost to Royals (69-53), 13-5 | Kingdome (33-32) | 57-65 | Lost 4 |
| » W: Terry Leach (4-3) L: Randy Johnson (5-8) | Sixth | 16½ out |
| Sunday, August 20 |
| » Lost to Royals (70-53), 5-4 | Kingdome (33-33) | 57-66 | Lost 5 |
| » W: Steve Crawford (2-0) L: Brian Holman (6-8) S: Jeff Montgomery (11) | Sixth | 17½ out |
| Tuesday, August 22 |
| » Lost to Indians (59-66), 3-2 | Cleveland Stadium (2-2) | 57-67 | Lost 6 |
| » W: Doug Jones (5-7) L: Mike Schooler (1-4) | Sixth | 19 out |
| Wednesday, August 23 |
| » Lost to Indians (60-66), 5-3 | Cleveland Stadium (2-3) | 57-68 | Lost 7 |
| » W: Tom Candiotti (12-6) L: Mike Dunne (3-9) S: Doug Jones (29) | Sixth | 20 out |
| Thursday, August 24 |
| » Lost to Indians (61-66), 5-2 | Cleveland Stadium (2-4) | 57-69 | Lost 8 |
| » W: Steve Davis (1-0) L: Clint Zavaras (1-4) S: Doug Jones (30) | Sixth | 20 out |
| Friday, August 25 |
| » Lost to Twins (63-64), 2-1 | Hubert H. Humphrey Metrodome (1-3) | 57-70 | Lost 9 |
| » W: Mike Dyer (2-3) L: Randy Johnson (5-9) S: Jeff Reardon (25) | Sixth | 20 out |
| Saturday, August 26 |
| » Lost to Twins (64-64), 1-0 | Hubert H. Humphrey Metrodome (1-4) | 57-71 | Lost 10 |
| » W: David West (1-2) L: Brian Holman (6-9) S: Jeff Reardon (26) | Sixth | 20 out |
| Sunday, August 27 |
| » Lost to Twins (65-64), 8-5 | Hubert H. Humphrey Metrodome (1-5) | 57-72 | Lost 11 |
| » W: Mark Guthrie (1-0) L: Scott Bankhead (11-6) S: Juan Berenguer (3) | Sixth | 21 out |
| » Major-league debuts: Chip Hale (Twins) |
| Monday, August 28 |
| » Lost to Twins (66-64), 5-4 | Hubert H. Humphrey Metrodome (1-6) | 57-73 | Lost 12 |
| » W: Jeff Reardon (5-3) L: Mike Schooler (1-5) | Sixth | 22 out |
| Tuesday, August 29 |
| » Defeated Brewers (66-68), 5-3 | County Stadium (2-2) | 58-73 | |
| » W: Erik Hanson (5-4) L: Jaime Navarro (4-6) S: Mike Schooler (25) | Sixth | 22 out |
| Wednesday, August 30 |
| » Defeated Brewers (66-69), 7-3 | County Stadium (3-2) | 59-73 | Won 2 |
| » W: Randy Johnson (6-9) L: Jeff Peterek (0-2) S: Mike Jackson (6) | Sixth | 21 out |
| Thursday, August 31 |
| » Lost to Brewers (67-69), 6-1 | County Stadium (3-3) | 59-74 | |
| » W: Mark Knudson (5-4) L: Brian Holman (6-10) | Fifth | 21½ out |
| Friday, September 1 |
| » Defeated Red Sox (68-67), 7-2 | Fenway Park (1-3) | 60-74 | |
| » W: Scott Bankhead (12-6) L: Mike Smithson (7-13) S: Mike Jackson (7) | Sixth | 20½ out |
| Saturday, September 2 |
| » Lost to Red Sox (69-67), 6-5 | Fenway Park (1-4) | 60-75 | |
| » W: Dennis Lamp (4-1) L: Mike Dunne (3-10) S: Lee Smith (20) | Sixth | 21½ out |
| Sunday, September 3 |
| » Defeated Red Sox (69-68), 3-2 | Fenway Park (2-4) | 61-75 | |
| » W: Erik Hanson (6-4) L: Oil Can Boyd (2-2) S: Mike Schooler (26) | Sixth | 21½ out |
| Tuesday, September 5 |
| » Lost to Yankees (64-76), 12-2 | Kingdome (33-34) | 61-76 | |
| » W: Eric Plunk (6-4) L: Randy Johnson (6-10) | Sixth | 22 out |
| Wednesday, September 6 |
| » Lost to Yankees (65-76), 5-3 | Kingdome (33-35) | 61-77 | Lost 2 |
| » W: Walt Terrell (9-17) L: Brian Holman (6-11) S: Dave Righetti (22) | Sixth | 23 out |
| Thursday, September 7 |
| » Lost to Yankees (66-76), 6-4 | Kingdome (33-36) | 61-78 | Lost 3 |
| » W: Rich Gossage (3-1) L: Mike Schooler (1-6) S: Dave Righetti (23) | Sixth | 23½ out |
| Friday, September 8 |
| » Lost to Brewers (71-72), 7-3 | Kingdome (33-37) | 61-79 | Lost 4 |
| » W: Jaime Navarro (5-7) L: Clint Zavaras (1-5) | Sixth | 23½ out |
| Saturday, September 9 |
| » Lost to Brewers (72-72), 7-3 | Kingdome (33-38) | 61-80 | Lost 5 |
| » W: Jerry Reuss (9-7) L: Erik Hanson (6-5) | Sixth | 24½ out |
| Sunday, September 10 |
| » Lost to Brewers (73-72), 7-1 | Kingdome (33-39) | 61-81 | Lost 6 |
| » W: Mark Knudson (6-5) L: Randy Johnson (6-11) | Sixth | 25½ out |
| Monday, September 11 |
| » Defeated Red Sox (70-74), 2-1 | Kingdome (34-39) | 62-81 | |
| » W: Brian Holman (7-11) L: John Dopson (10-7) S: Mike Schooler (27) | Sixth | 25 out |
| Tuesday, September 12 |
| » Defeated Red Sox (70-75), 5-3 | Kingdome (35-39) | 63-81 | Won 2 |
| » W: Scott Bankhead (13-6) L: Eric Hetzel (1-3) S: Mike Schooler (28) | Sixth | 24 out |
| Wednesday, September 13 |
| » Defeated Red Sox (70-76), 7-4 | Kingdome (36-39) | 64-81 | Won 3 |
| » W: Jerry Reed (6-6) L: Mike Boddicker (12-11) S: Mike Schooler (29) | Sixth | 24 out |
| Friday, September 15 |
| » Defeated Yankees (67-81), 3-1 | Yankee Stadium (2-2) | 65-81 | Won 4 |
| » W: Erik Hanson (7-5) L: Andy Hawkins (14-14) | Fifth | 23 out |
| Saturday, September 16 |
| » Lost to Yankees (68-81), 4-1 | Yankee Stadium (2-3) | 65-82 | |
| » W: Eric Plunk (7-5) L: Randy Johnson (6-12) S: Lee Guetterman (12) | Fifth | 23 out |
| Sunday, September 17 |
| » Defeated Yankees (68-82), 3-0 | Yankee Stadium (3-3) | 66-82 | |
| » W: Brian Holman (8-11) L: Walt Terrell (9-18) S: Mike Schooler (30) | Fifth | 22 out |
| Monday, September 18 |
| » Lost to Rangers (76-73), 5-2 | Arlington Stadium (2-2) | 66-83 | |
| » W: Cecilio Guante (6-5) L: Mike Jackson (4-6) | Sixth | 23 out |
| Tuesday, September 19 |
| » Lost to Rangers (77-73), 5-3 | Arlington Stadium (2-3) | 66-84 | Lost 2 |
| » W: Brad Arnsberg (2-0) L: Jerry Reed (6-7) S: Jeff Russell (35) | Sixth | 24 out |
| Wednesday, September 20 |
| » Lost to Rangers (78-73), 3-2 | Arlington Stadium (2-4) | 66-85 | Lost 3 |
| » W: Mike Jeffcoat (9-5) L: Keith Comstock (1-2) S: Jeff Russell (36) | Sixth | 25 out |
| Thursday, September 21 |
|