| Monday, January 23 |
| Former Indian George Case dies in Trenton, NJ at the age of 74. |
| Monday, April 3 |
| » Defeated Brewers (0-1), 2-1 | Cleveland Stadium (1-0) | 1-0 | |
| » W: Greg Swindell (1-0) L: Don August (0-1) S: Doug Jones (1) | First | -- |
| Thursday, April 6 |
| » Lost to Brewers (1-1), 3-0 | Cleveland Stadium (1-1) | 1-1 | |
| » W: Chris Bosio (1-0) L: Bud Black (0-1) | Second | 1 out |
| Friday, April 7 |
| » Defeated Yankees (1-3), 4-2 | Yankee Stadium (1-0) | 2-1 | |
| » W: Rich Yett (1-0) L: John Candelaria (0-1) S: Doug Jones (2) | First | -- |
| Saturday, April 8 |
| » Defeated Yankees (1-4), 11-1 | Yankee Stadium (2-0) | 3-1 | Won 2 |
| » W: Greg Swindell (2-0) L: Al Leiter (0-1) | First | -- |
| Sunday, April 9 |
| » Defeated Yankees (1-5), 4-3 | Yankee Stadium (3-0) | 4-1 | Won 3 |
| » W: Tom Candiotti (1-0) L: Tommy John (1-1) S: Doug Jones (3) | First | -- |
| Monday, April 10 |
| » Lost to Red Sox (2-4), 5-2 | Fenway Park (0-1) | 4-2 | |
| » W: Mike Boddicker (1-0) L: Joe Skalski (0-1) S: Mike Smithson (2) | First | -- |
| Wednesday, April 12 |
| » Defeated Red Sox (2-5), 10-6 | Fenway Park (1-1) | 5-2 | |
| » W: Bud Black (1-1) L: Oil Can Boyd (0-1) S: Keith Atherton (1) | First | -- |
| Thursday, April 13 |
| » Lost to Red Sox (3-5), 9-1 | Fenway Park (1-2) | 5-3 | |
| » W: Roger Clemens (1-0) L: Rich Yett (1-1) | First | -- |
| Friday, April 14 |
| » Lost to Brewers (3-5), 8-4 | County Stadium (0-1) | 5-4 | Lost 2 |
| » W: Mark Knudson (1-0) L: Joe Skalski (0-2) S: Dan Plesac (2) | First | -- |
| Saturday, April 15 |
| » Lost to Brewers (4-5), 5-1 | County Stadium (0-2) | 5-5 | Lost 3 |
| » W: Chris Bosio (2-0) L: Tom Candiotti (1-1) S: Chuck Crim (1) | First | -- |
| Sunday, April 16 |
| » Lost to Brewers (5-5), 4-3 | County Stadium (0-3) | 5-6 | Lost 4 |
| » W: Chuck Crim (1-1) L: Keith Atherton (0-1) | Third | ½ out |
| Wednesday, April 19 |
| » Lost to Red Sox (6-6), 8-4 | Cleveland Stadium (1-2) | 5-7 | Lost 5 |
| » W: Roger Clemens (2-0) L: Bud Black (1-2) | Fourth | 1 out |
| Thursday, April 20 |
| » Lost to Red Sox (7-6), 5-2 | Cleveland Stadium (1-3) | 5-8 | Lost 6 |
| » W: Oil Can Boyd (1-1) L: Rich Yett (1-2) S: Lee Smith (1) | Sixth | 2 out |
| Friday, April 21 |
| » Defeated Yankees (6-9), 6-5 | Cleveland Stadium (2-3) | 6-8 | |
| » W: Doug Jones (1-0) L: Dale Mohorcic (0-1) | Fourth | 1 out |
| Saturday, April 22 |
| » Defeated Yankees (6-10), 3-1 | Cleveland Stadium (3-3) | 7-8 | Won 2 |
| » W: Scott Bailes (1-0) L: Tommy John (1-3) | Third | ½ out |
| Sunday, April 23 |
| » Lost to Yankees (7-10), 5-0 | Cleveland Stadium (3-4) | 7-9 | |
| » W: Andy Hawkins (2-2) L: John Farrell (0-1) | Third | 1½ out |
| Monday, April 24 |
| » Lost to Yankees (8-10), 6-3 | Cleveland Stadium (3-5) | 7-10 | Lost 2 |
| » W: Dave LaPoint (2-1) L: Bud Black (1-3) S: Dave Righetti (2) | Sixth | 1½ out |
| Tuesday, April 25 |
| » Lost to Rangers (14-4), 11-7 | Cleveland Stadium (3-6) | 7-11 | Lost 3 |
| » W: Bobby Witt (3-0) L: Scott Bailes (1-1) S: Brad Arnsberg (1) | Seventh | 2½ out |
| Wednesday, April 26 |
| » Lost to Rangers (15-4), 3-2 | Cleveland Stadium (3-7) | 7-12 | Lost 4 |
| » W: Jeff Russell (2-0) L: Doug Jones (1-1) | Seventh | 3½ out |
| Friday, April 28 |
| » Defeated Twins (9-11), 9-7 | Hubert H. Humphrey Metrodome (1-0) | 8-12 | |
| » W: Tom Candiotti (2-1) L: Shane Rawley (1-3) S: Doug Jones (4) | Fifth | 2 out |
| Saturday, April 29 |
| » Defeated Twins (9-12), 4-1 | Hubert H. Humphrey Metrodome (2-0) | 9-12 | Won 2 |
| » W: John Farrell (1-1) L: Frank Viola (0-4) S: Doug Jones (5) | Third | 1 out |
| Sunday, April 30 |
| » Lost to Twins (10-12), 2-1 | Hubert H. Humphrey Metrodome (2-1) | 9-13 | |
| » W: Roy Smith (2-1) L: Bud Black (1-4) S: Jeff Reardon (3) | Third | 2 out |
| Monday, May 1 |
| » Defeated Rangers (17-6), 11-1 | Arlington Stadium (1-0) | 10-13 | |
| » W: Rich Yett (2-2) L: Bobby Witt (3-1) S: Keith Atherton (2) | Third | 1½ out |
| Tuesday, May 2 |
| » Defeated Rangers (17-7), 8-3 | Arlington Stadium (2-0) | 11-13 | Won 2 |
| » W: Greg Swindell (3-0) L: Jamie Moyer (3-1) | Fourth | 1½ out |
| Wednesday, May 3 |
| » Defeated Royals (17-9), 6-2 | Cleveland Stadium (4-7) | 12-13 | Won 3 |
| » W: Tom Candiotti (3-1) L: Charlie Leibrandt (2-3) | Third | 1 out |
| Thursday, May 4 |
| » Defeated Royals (17-10), 3-1 | Cleveland Stadium (5-7) | 13-13 | Won 4 |
| » W: John Farrell (2-1) L: Bret Saberhagen (2-3) S: Doug Jones (6) | First | -- |
| Friday, May 5 |
| » Lost to Twins (11-16), 3-2 | Cleveland Stadium (5-8) | 13-14 | |
| » W: German Gonzalez (3-1) L: Doug Jones (1-2) | Fourth | 1 out |
| Sunday, May 7 |
| » Defeated Twins (11-17), 5-4 | Cleveland Stadium (6-8) | 14-14 | |
| » W: Doug Jones (2-2) L: Francisco Oliveras (0-1) | Second | 1 out |
| » Defeated Twins (11-18), 12-1 | Cleveland Stadium (7-8) | 15-14 | Won 2 |
| » W: Rich Yett (3-2) L: Freddie Toliver (1-2) | Second | 1 out |
| Former Indian Howie Moss dies in Baltimore, MD at the age of 70. |
| Tuesday, May 9 |
| » Lost to Royals (19-12), 3-1 | Royals Stadium (0-1) | 15-15 | |
| » W: Bret Saberhagen (3-3) L: Tom Candiotti (3-2) | Second | ½ out |
| Wednesday, May 10 |
| » Lost to Royals (20-12), 3-2 | Royals Stadium (0-2) | 15-16 | Lost 2 |
| » W: Jeff Montgomery (4-1) L: John Farrell (2-2) S: Steve Farr (7) | Third | 1 out |
| Friday, May 12 |
| » Lost to Tigers (11-21), 6-3 | Cleveland Stadium (7-9) | 15-17 | Lost 3 |
| » W: Jack Morris (2-6) L: Bud Black (1-5) | Third | 2 out |
| Saturday, May 13 |
| » Defeated Tigers (11-22), 3-1 | Cleveland Stadium (8-9) | 16-17 | |
| » W: Greg Swindell (4-0) L: Doyle Alexander (3-4) | Third | 1 out |
| Sunday, May 14 |
| » Defeated Tigers (11-23), 8-3 | Cleveland Stadium (9-9) | 17-17 | Won 2 |
| » W: Tom Candiotti (4-2) L: Paul Gibson (1-3) | First | -- |
| Monday, May 15 |
| » Lost to Blue Jays (13-24), 5-3 | Exhibition Stadium (0-1) | 17-18 | |
| » W: Jimmy Key (4-2) L: John Farrell (2-3) | Second | ½ out |
| Tuesday, May 16 |
| » Lost to Blue Jays (14-24), 7-6 | Exhibition Stadium (0-2) | 17-19 | Lost 2 |
| » W: Tom Henke (2-3) L: Keith Atherton (0-2) S: Duane Ward (2) | Third | ½ out |
| Wednesday, May 17 |
| » Defeated Blue Jays (14-25), 6-3 | Exhibition Stadium (1-2) | 18-19 | |
| » W: Bud Black (2-5) L: Dave Stieb (3-2) S: Doug Jones (7) | First | -- |
| Thursday, May 18 |
| » Lost to Orioles (17-19), 3-2 | Memorial Stadium (0-1) | 18-20 | |
| » W: Mark Williamson (1-2) L: Keith Atherton (0-3) | Second | ½ out |
| Friday, May 19 |
| » Defeated Orioles (17-20), 4-1 | Memorial Stadium (1-1) | 19-20 | |
| » W: Tom Candiotti (5-2) L: Jose Bautista (2-4) S: Doug Jones (8) | Second | ½ out |
| Saturday, May 20 |
| » Lost to Orioles (18-20), 5-1 | Memorial Stadium (1-2) | 19-21 | |
| » W: Jeff Ballard (7-1) L: John Farrell (2-4) | Second | ½ out |
| Sunday, May 21 |
| » Defeated Orioles (18-21), 2-0 | Memorial Stadium (2-2) | 20-21 | |
| » W: Rich Yett (4-2) L: Brian Holton (1-4) S: Doug Jones (9) | First | -- |
| Monday, May 22 |
| » Defeated Tigers (16-25), 7-3 | Tiger Stadium (1-0) | 21-21 | Won 2 |
| » W: Bud Black (3-5) L: Jack Morris (2-7) S: Jesse Orosco (1) | First | -- |
| Tuesday, May 23 |
| » Lost to Tigers (17-25), 7-2 | Tiger Stadium (1-1) | 21-22 | |
| » W: Mike Trujillo (1-0) L: Greg Swindell (4-1) | Second | 1 out |
| Wednesday, May 24 |
| » Lost to Tigers (18-25), 2-1 | Tiger Stadium (1-2) | 21-23 | Lost 2 |
| » W: Willie Hernandez (2-1) L: Scott Bailes (1-2) | Second | 1 out |
| Thursday, May 25 |
| » Lost to Tigers (19-25), 9-5 | Tiger Stadium (1-3) | 21-24 | Lost 3 |
| » W: Frank Tanana (4-4) L: John Farrell (2-5) S: Willie Hernandez (9) | Fourth | 2 out |
| Friday, May 26 |
| » Lost to Orioles (22-21), 5-2 | Cleveland Stadium (9-10) | 21-25 | Lost 4 |
| » W: Jeff Ballard (8-1) L: Rich Yett (4-3) S: Gregg Olson (3) | Fourth | 2½ out |
| Saturday, May 27 |
| » Lost to Orioles (23-21), 5-1 | Cleveland Stadium (9-11) | 21-26 | Lost 5 |
| » W: Dave Schmidt (4-4) L: Bud Black (3-6) S: Mark Huismann (1) | Fourth | 3½ out |
| Sunday, May 28 |
| » Defeated Orioles (23-22), 1-0 | Cleveland Stadium (10-11) | 22-26 | |
| » W: Greg Swindell (5-1) L: Bob Milacki (2-5) | Third | 2½ out |
| Monday, May 29 |
| » Defeated Blue Jays (20-29), 5-3 | Cleveland Stadium (11-11) | 23-26 | Won 2 |
| » W: Tom Candiotti (6-2) L: Mike Flanagan (3-5) S: Doug Jones (10) | Third | 2½ out |
| Tuesday, May 30 |
| » Defeated Blue Jays (20-30), 6-2 | Cleveland Stadium (12-11) | 24-26 | Won 3 |
| » W: John Farrell (3-5) L: Alex Sanchez (0-1) | Third | 2½ out |
| Wednesday, May 31 |
| » Defeated Blue Jays (20-31), 7-4 | Cleveland Stadium (13-11) | 25-26 | Won 4 |
| » W: Bud Black (4-6) L: Jimmy Key (6-3) S: Doug Jones (11) | Third | 2½ out |
| Friday, June 2 |
| » Defeated Athletics (34-19), 5-3 | Oakland-Alameda County Stadium (1-0) | 26-26 | Won 5 |
| » W: Greg Swindell (6-1) L: Mike Moore (6-4) S: Doug Jones (12) | Second | 3 out |
| Saturday, June 3 |
| » Lost to Athletics (35-19), 7-0 | Oakland-Alameda County Stadium (1-1) | 26-27 | |
| » W: Bob Welch (7-4) L: Tom Candiotti (6-3) | Second | 4 out |
| Sunday, June 4 |
| » Lost to Athletics (36-19), 4-0 | Oakland-Alameda County Stadium (1-2) | 26-28 | Lost 2 |
| » W: Dave Stewart (10-2) L: John Farrell (3-6) | Second | 5 out |
| Monday, June 5 |
| » Defeated Angels (35-19), 7-3 | Anaheim Stadium (1-0) | 27-28 | |
| » W: Bud Black (5-6) L: Mike Witt (3-6) | Second | 5 out |
| Tuesday, June 6 |
| » Lost to Angels (36-19), 2-1 | Anaheim Stadium (1-1) | 27-29 | |
| » W: Dan Petry (2-0) L: Rich Yett (4-4) S: Bryan Harvey (6) | Second | 5 out |
| Wednesday, June 7 |
| » Defeated Angels (36-20), 1-0 | Anaheim Stadium (2-1) | 28-29 | |
| » W: Greg Swindell (7-1) L: Chuck Finley (7-4) | Second | 4½ out |
| Thursday, June 8 |
| Former Indian Bibb Falk dies in Austin, TX at the age of 91. |
| Friday, June 9 |
| » Defeated Mariners (28-33), 5-4 | Cleveland Stadium (14-11) | 29-29 | Won 2 |
| » W: Tom Candiotti (7-3) L: Clint Zavaras (0-2) S: Doug Jones (13) | Second | 4 out |
| Saturday, June 10 |
| » Lost to Mariners (29-33), 3-1 | Cleveland Stadium (14-12) | 29-30 | |
| » W: Randy Johnson (3-4) L: John Farrell (3-7) S: Mike Schooler (14) | Second | 4 out |
| Sunday, June 11 |
| » Lost to Mariners (30-33), 6-3 | Cleveland Stadium (14-13) | 29-31 | Lost 2 |
| » W: Brian Holman (2-3) L: Bud Black (5-7) S: Gene Harris (1) | Second | 4 out |
| Monday, June 12 |
| » Lost to White Sox (23-40), 5-3 | Comiskey Park I (0-1) | 29-32 | Lost 3 |
| » W: Steve Rosenberg (2-2) L: Rich Yett (4-5) S: Bobby Thigpen (11) | Third | 4½ out |
| Tuesday, June 13 |
| » Defeated White Sox (23-41), 9-6 | Comiskey Park I (1-1) | 30-32 | |
| » W: Greg Swindell (8-1) L: Adam Peterson (0-1) S: Doug Jones (14) | Second | 4½ out |
| Wednesday, June 14 |
| » Lost to White Sox (24-41), 3-1 | Comiskey Park I (1-2) | 30-33 | |
| » W: Jerry Reuss (6-2) L: Tom Candiotti (7-4) S: Bobby Thigpen (12) | Third | 4½ out |
| Thursday, June 15 |
| » Lost to Royals (39-25), 5-4 | Cleveland Stadium (14-14) | 30-34 | Lost 2 |
| » W: Bret Saberhagen (6-4) L: Doug Jones (2-3) S: Steve Farr (15) | Third | 5½ out |
| Friday, June 16 |
| » Defeated Royals (39-26), 1-0 | Cleveland Stadium (15-14) | 31-34 | |
| » W: Bud Black (6-7) L: Terry Leach (1-1) | Third | 5 out |
| Saturday, June 17 |
| » Defeated Royals (39-27), 4-3 | Cleveland Stadium (16-14) | 32-34 | Won 2 |
| » W: Scott Bailes (2-2) L: Mark Gubicza (6-5) S: Doug Jones (15) | Third | 5 out |
| Sunday, June 18 |
| » Defeated Royals (39-28), 4-1 | Cleveland Stadium (17-14) | 33-34 | Won 3 |
| » W: Greg Swindell (9-1) L: Kevin Appier (1-2) | Second | 5 out |
| Tuesday, June 20 |
| » Lost to Twins (33-35), 7-4 | Cleveland Stadium (17-15) | 33-35 | |
| » W: Allan Anderson (8-4) L: Tom Candiotti (7-5) S: Jeff Reardon (13) | Third | 6½ out |
| Wednesday, June 21 |
| » Lost to Twins (34-35), 5-1 | Cleveland Stadium (17-16) | 33-36 | Lost 2 |
| » W: Shane Rawley (4-6) L: John Farrell (3-8) S: Randy St.claire (1) | Fourth | 7½ out |
| Thursday, June 22 |
| » Lost to Twins (35-35), 9-8 | Cleveland Stadium (17-17) | 33-37 | Lost 3 |
| » W: Gary Wayne (2-0) L: Jesse Orosco (0-1) S: Jeff Reardon (14) | Fifth | 8½ out |
| Friday, June 23 |
| » Lost to Rangers (40-31), 4-0 | Arlington Stadium (2-1) | 33-38 | Lost 4 |
| » W: Mike Jeffcoat (3-1) L: Scott Bailes (2-3) | Sixth | 8½ out |
| Saturday, June 24 |
| » Defeated Rangers (40-32), 7-3 | Arlington Stadium (3-1) | 34-38 | |
| » W: Greg Swindell (10-1) L: Charlie Hough (5-7) S: Doug Jones (16) | Fifth | 7½ out |
| Sunday, June 25 |
| » Lost to Rangers (41-32), 4-2 | Arlington Stadium (3-2) | 34-39 | |
| » W: Nolan Ryan (9-3) L: Tom Candiotti (7-6) S: Jeff Russell (17) | Sixth | 7½ out |
| Monday, June 26 |
| » Defeated Rangers (41-33), 4-3 | Arlington Stadium (4-2) | 35-39 | |
| » W: John Farrell (4-8) L: Bobby Witt (5-8) S: Doug Jones (17) | Fifth | 7 out |
| Tuesday, June 27 |
| » Lost to Angels (43-30), 2-1 | Cleveland Stadium (17-18) | 35-40 | |
| » W: Rich Monteleone (2-0) L: Neil Allen (0-1) S: Bryan Harvey (10) | Sixth | 8 out |
| Wednesday, June 28 |
| » Defeated Angels (43-31), 2-1 | Cleveland Stadium (18-18) | 36-40 | |
| » W: Scott Bailes (3-3) L: Jim Abbott (6-5) S: Doug Jones (18) | Fourth | 8 out |
| Friday, June 30 |
| » Lost to Athletics (47-32), 5-0 | Cleveland Stadium (18-19) | 36-41 | |
| » W: Bob Welch (9-4) L: Greg Swindell (10-2) S: Rick Honeycutt (9) | Fifth | 7½ out |
| Saturday, July 1 |
| » Lost to Athletics (48-32), 6-4 | Cleveland Stadium (18-20) | 36-42 | Lost 2 |
| » W: Mike Moore (10-5) L: Rich Yett (4-6) S: Todd Burns (5) | Fifth | 8½ out |
| Sunday, July 2 |
| » Lost to Athletics (49-32), 11-3 | Cleveland Stadium (18-21) | 36-43 | Lost 3 |
| » W: Storm Davis (7-3) L: John Farrell (4-9) | Sixth | 8½ out |
| Monday, July 3 |
| » Defeated White Sox (32-51), 4-2 | Cleveland Stadium (19-21) | 37-43 | |
| » W: Bud Black (7-7) L: Shawn Hillegas (4-8) S: Doug Jones (19) | Sixth | 8½ out |
| Tuesday, July 4 |
| » Defeated White Sox (32-52), 3-2 | Cleveland Stadium (20-21) | 38-43 | Won 2 |
| » W: Scott Bailes (4-3) L: Melido Perez (5-10) S: Doug Jones (20) | Fifth | 8½ out |
| Wednesday, July 5 |
| » Defeated White Sox (32-53), 4-2 | Cleveland Stadium (21-21) | 39-43 | Won 3 |
| » W: Greg Swindell (11-2) L: Jerry Reuss (7-5) S: Doug Jones (21) | Fifth | 8½ out |
| Friday, July 7 |
| » Defeated Mariners (40-44), 4-3 | Kingdome (1-0) | 40-43 | Won 4 |
| » W: Doug Jones (3-3) L: Mike Jackson (3-3) | Fourth | 7 out |
| Saturday, July 8 |
| » Lost to Mariners (41-44), 4-3 | Kingdome (1-1) | 40-44 | |
| » W: Bill Swift (5-2) L: Jesse Orosco (0-2) | Fifth | 8 out |
| Sunday, July 9 |
| » Lost to Mariners (42-44), 8-0 | Kingdome (1-2) | 40-45 | Lost 2 |
| » W: Scott Bankhead (8-4) L: Scott Bailes (4-4) | Fifth | 8 out |
| Thursday, July 13 |
| » Lost to Rangers (48-39), 9-3 | Cleveland Stadium (21-22) | 40-46 | Lost 3 |
| » W: Jeff Russell (5-2) L: Rod Nichols (0-1) | Fifth | 8 out |
| Friday, July 14 |
| » Defeated Rangers (48-40), 11-5 | Cleveland Stadium (22-22) | 41-46 | |
| » W: Jesse Orosco (1-2) L: Cecilio Guante (4-4) S: Doug Jones (22) | Sixth | 8 out |
| Saturday, July 15 |
| » Defeated Rangers (48-41), 7-1 | Cleveland Stadium (23-22) | 42-46 | Won 2 |
| » W: Greg Swindell (12-2) L: Nolan Ryan (10-5) | Fifth | 8 out |
| » Major-league debuts: Albert Belle (Indians) |
| Sunday, July 16 |
| » Defeated Rangers (48-42), 11-5 | Cleveland Stadium (24-22) | 43-46 | Won 3 |
| » W: Rich Yett (5-6) L: Kevin Brown (7-6) | Fifth | 8 out |
| Monday, July 17 |
| » Lost to Twins (44-48), 5-2 | Hubert H. Humphrey Metrodome (2-2) | 43-47 | |
| » W: Juan Berenguer (6-3) L: Doug Jones (3-4) S: Jeff Reardon (16) | Fifth | 9 out |
| Tuesday, July 18 |
| » Lost to Twins (45-48), 5-4 | Hubert H. Humphrey Metrodome (2-3) | 43-48 | Lost 2 |
| » W: Frank Viola (8-10) L: Doug Jones (3-5) | Fifth | 10 out |
| Wednesday, July 19 |
| » Defeated Twins (45-49), 10-1 | Hubert H. Humphrey Metrodome (3-3) | 44-48 | |
| » W: John Farrell (5-9) L: Allan Anderson (9-9) | Fifth | 9 out |
| Thursday, July 20 |
| » Defeated Royals (53-42), 4-0 | Royals Stadium (1-2) | 45-48 | Won 2 |
| » W: Greg Swindell (13-2) L: Bret Saberhagen (9-5) | Fourth | 8 out |
| Friday, July 21 |
| » Lost to Royals (54-42), 6-1 | Royals Stadium (1-3) | 45-49 | |
| » W: Luis Aquino (5-4) L: Scott Bailes (4-5) S: Jeff Montgomery (4) | Fifth | 8 out |
| Saturday, July 22 |
| » Defeated Royals (54-43), 1-0 | Royals Stadium (2-3) | 46-49 | |
| » W: Tom Candiotti (8-6) L: Tom Gordon (11-3) S: Doug Jones (23) | Third | 7 out |
| Sunday, July 23 |
| » Defeated Royals (54-44), 17-5 | Royals Stadium (3-3) | 47-49 | Won 2 |
| » W: Bud Black (8-7) L: Mark Gubicza (9-8) | Second | 6 out |
| Monday, July 24 |
| » Defeated Yankees (46-52), 7-3 | Cleveland Stadium (25-22) | 48-49 | Won 3 |
| » W: John Farrell (6-9) L: Lee Guetterman (2-4) | Second | 5½ out |
| Tuesday, July 25 |
| » Lost to Yankees (47-52), 5-1 | Cleveland Stadium (25-23) | 48-50 | |
| » W: Andy Hawkins (12-9) L: Greg Swindell (13-3) | Third | 5½ out |
| Wednesday, July 26 |
| » Defeated Yankees (47-53), 9-7 | Cleveland Stadium (26-23) | 49-50 | |
| » W: Doug Jones (4-5) L: Lee Guetterman (2-5) | Second | 4½ out |
| Friday, July 28 |
| » Defeated Red Sox (47-50), 3-2 | Cleveland Stadium (27-23) | 50-50 | Won 2 |
| » W: Tom Candiotti (9-6) L: Roger Clemens (11-8) | Second | 3½ out |
| » Defeated Red Sox (47-51), 2-1 | Cleveland Stadium (28-23) | 51-50 | Won 3 |
| » W: Rod Nichols (1-1) L: Wes Gardner (2-6) S: Doug Jones (24) | Second | 3½ out |
| Saturday, July 29 |
| » Lost to Red Sox (48-51), 5-0 | Cleveland Stadium (28-24) | 51-51 | |
| » W: Mike Smithson (5-9) L: Bud Black (8-8) | Second | 3½ out |
| » Major-league debuts: Steve Olin (Indians) |
| Sunday, July 30 |
| » Lost to Red Sox (49-51), 5-2 | Cleveland Stadium (28-25) | 51-52 | Lost 2 |
| » W: Dennis Lamp (1-1) L: John Farrell (6-10) S: Rob Murphy (6) | Second | 3½ out |
| Monday, July 31 |
| » Lost to Brewers (51-54), 6-1 | County Stadium (0-4) | 51-53 | Lost 3 |
| » W: Teddy Higuera (6-4) L: Scott Bailes (4-6) S: Chuck Crim (5) | Fourth | 3½ out |
| Tuesday, August 1 |
| » Lost to Brewers (52-54), 4-2 | County Stadium (0-5) | 51-54 | Lost 4 |
| » W: Jaime Navarro (3-3) L: Doug Jones (4-6) S: Dan Plesac (25) | Fourth | 3 out |
| Wednesday, August 2 |
| » Defeated Brewers (52-55), 1-0 | County Stadium (1-5) | 52-54 | |
| » W: Tom Candiotti (10-6) L: Chris Bosio (12-7) S: Jesse Orosco (2) | Fourth | 3 out |
| Thursday, August 3 |
| » Defeated Red Sox (52-53), 4-2 | Fenway Park (2-2) | 53-54 | Won 2 |
| » W: Rod Nichols (2-1) L: Tom Bolton (0-1) S: Doug Jones (25) | Third | 2½ out |
| Friday, August 4 |
| » Defeated Red Sox (52-54), 4-3 | Fenway Park (3-2) | 54-54 | Won 3 |
| » W: Bud Black (9-8) L: Mike Boddicker (9-8) S: Doug Jones (26) | Second | 1½ out |
| Saturday, August 5 |
| » Lost to Red Sox (53-54), 10-2 | Fenway Park (3-3) | 54-55 | |
| » W: Mike Smithson (6-9) L: John Farrell (6-11) | Third | 2½ out |
| Sunday, August 6 |
| » Lost to Red Sox (54-54), 6-4 | Fenway Park (3-4) | 54-56 | Lost 2 |
| » W: Rob Murphy (3-5) L: Jesse Orosco (1-3) | Fourth | 3½ out |
| Monday, August 7 |
| » Lost to Yankees (53-59), 9-0 | Yankee Stadium (3-1) | 54-57 | Lost 3 |
| » W: Greg Cadaret (3-2) L: Scott Bailes (4-7) | Fourth | 3½ out |
| Tuesday, August 8 |
| » Defeated Yankees (53-60), 3-1 | Yankee Stadium (4-1) | 55-57 | |
| » W: Tom Candiotti (11-6) L: Chuck Cary (2-1) S: Doug Jones (27) | Fourth | 3½ out |
| Wednesday, August 9 |
| » Defeated Yankees (53-61), 7-4 | Yankee Stadium (5-1) | 56-57 | Won 2 |
| » W: Rod Nichols (3-1) L: Andy Hawkins (13-11) S: Steve Olin (1) | Third | 2½ out |
| Thursday, August 10 |
| » Lost to Brewers (56-59), 10-3 | Cleveland Stadium (28-26) | 56-58 | |
| » W: Teddy Higuera (8-4) L: Bud Black (9-9) | Fourth | 3 out |
| » Major-league debuts: Kevin Wickander (Indians) Greg Vaughn (Brewers) |
| Friday, August 11 |
| » Defeated Brewers (56-60), 5-0 | Cleveland Stadium (29-26) | 57-58 | |
| » W: John Farrell (7-11) L: Jaime Navarro (3-5) | Fourth | 3 out |
| » Lost to Brewers (57-60), 8-7 | Cleveland Stadium (29-27) | 57-59 | |
| » W: Mark Knudson (3-3) L: Ed Wojna (0-1) S: Dan Plesac (28) | Fourth | 3 out |
| Saturday, August 12 |
| » Lost to Brewers (58-60), 5-1 | Cleveland Stadium (29-28) | 57-60 | Lost 2 |
| » W: Chris Bosio (13-7) L: Scott Bailes (4-8) | Fifth | 3 out |
| Sunday, August 13 |
| » Lost to Brewers (59-60), 5-4 | Cleveland Stadium (29-29) | 57-61 | Lost 3 |
| » W: Dan Plesac (3-3) L: Doug Jones (4-7) | Fifth | 4 out |
| Tuesday, August 15 |
| » Lost to Athletics (72-47), 5-2 | Oakland-Alameda County Stadium (1-3) | 57-62 | Lost 4 |
| » W: Storm Davis (13-5) L: Rod Nichols (3-2) S: Dennis Eckersley (24) | Fifth | 5½ out |
| Wednesday, August 16 |
| » Defeated Athletics (72-48), 6-3 | Oakland-Alameda County Stadium (2-3) | 58-62 | |
| » W: Steve Olin (1-0) L: Rick Honeycutt (2-2) S: Doug Jones (28) | Fifth | 4½ out |
| Thursday, August 17 |
| » Lost to Athletics (73-48), 1-0 | Oakland-Alameda County Stadium (2-4) | 58-63 | |
| » W: Bob Welch (13-7) L: John Farrell (7-12) S: Dennis Eckersley (25) | Fifth | 5½ out |
| Friday, August 18 |
| » Lost to Angels (72-48), 6-5 | Anaheim Stadium (2-2) | 58-64 | Lost 2 |
| » W: Greg Minton (2-3) L: Steve Olin (1-1) S: Bryan Harvey (19) | Fifth | 5½ out |
| Saturday, August 19 |
| » Lost to Angels (73-48), 7-4 | Anaheim Stadium (2-3) | 58-65 | Lost 3 |
| » W: Bert Blyleven (13-2) L: Rod Nichols (3-3) S: Greg Minton (7) | Fifth | 5½ out |
| Sunday, August 20 |
| » Lost to Angels (74-48), 1-0 | Anaheim Stadium (2-4) | 58-66 | Lost 4 |
| » W: Kirk McCaskill (13-7) L: Bud Black (9-10) | Fifth | 6½ out |
| » Major-league debuts: John Orton (Angels) |
| Monday, August 21 |
| Former Indian Ted Wilks dies in Houston, TX at the age of 74. |
| Tuesday, August 22 |
| » Defeated Mariners (57-67), 3-2 | Cleveland Stadium (30-29) | 59-66 | |
| » W: Doug Jones (5-7) L: Mike Schooler (1-4) | Fifth | 7 out |
| Wednesday, August 23 |
| » Defeated Mariners (57-68), 5-3 | Cleveland Stadium (31-29) | 60-66 | Won 2 |
| » W: Tom Candiotti (12-6) L: Mike Dunne (3-9) S: Doug Jones (29) | Fifth | 7 out |
| Thursday, August 24 |
| » Defeated Mariners (57-69), 5-2 | Cleveland Stadium (32-29) | 61-66 | Won 3 |
| » W: Steve Davis (1-0) L: Clint Zavaras (1-4) S: Doug Jones (30) | Fifth | 6½ out |
| Friday, August 25 |
| » Lost to White Sox (54-74), 5-4 | Cleveland Stadium (32-30) | 61-67 | |
| » W: Richard Dotson (4-7) L: Jesse Orosco (1-4) S: Bobby Thigpen (27) | Fifth | 7½ out |
| Saturday, August 26 |
| » Lost to White Sox (55-74), 4-3 | Cleveland Stadium (32-31) | 61-68 | Lost 2 |
| » W: Steve Rosenberg (4-9) L: Bud Black (9-11) S: Bobby Thigpen (28) | Fifth | 8½ out |
| Sunday, August 27 |
| » Lost to White Sox (56-74), 9-3 | Cleveland Stadium (32-32) | 61-69 | Lost 3 |
| » W: Greg Hibbard (4-5) L: John Farrell (7-13) | Fifth | 9½ out |
| Tuesday, August 29 |
| » Defeated Orioles (71-61), 3-1 | Cleveland Stadium (33-32) | 62-69 | |
| » W: Doug Jones (6-7) L: Pete Harnisch (3-8) | Fifth | 8½ out |
| Wednesday, August 30 |
| » Lost to Orioles (72-61), 7-4 | Cleveland Stadium (33-33) | 62-70 | |
| » W: Jeff Ballard (15-6) L: Greg Swindell (13-4) S: Gregg Olson (22) | Fifth | 9½ out |
| Thursday, August 31 |
| » Defeated Orioles (72-62), 11-0 | Cleveland Stadium (34-33) | 63-70 | |
| » W: John Farrell (8-13) L: Dave Johnson (4-3) | Fourth | 8½ out |
| Friday, September 1 |
| » Lost to Tigers (48-89), 2-1 | Tiger Stadium (1-4) | 63-71 | |
| » W: Paul Gibson (4-8) L: Doug Jones (6-8) | Fifth | 9½ out |
| Saturday, September 2 |
| » Lost to Tigers (49-89), 10-4 | Tiger Stadium (1-5) | 63-72 | Lost 2 |
| » W: Jeff Robinson (4-4) L: Steve Davis (1-1) | Fifth | 10½ out |
| Sunday, September 3 |
| » Lost to Tigers (50-89), 12-3 | Tiger Stadium (1-6) | 63-73 | Lost 3 |
| » W: Jack Morris (4-11) L: Tom Candiotti (12-7) | Fifth | 10½ out |
| Monday, September 4 |
| » Lost to Orioles (74-64), 5-4 | Memorial Stadium (2-3) | 63-74 | Lost 4 |
| » W: Mark Williamson (10-3) L: Rod Nichols (3-4) | Fifth | 11½ out |
| Tuesday, September 5 |
| » Lost to Orioles (75-64), 3-1 | Memorial Stadium (2-4) | 63-75 | Lost 5 |
| » W: Bob Milacki (10-12) L: John Farrell (8-14) S: Gregg Olson (24) | Fifth | 12½ out |
| Wednesday, September 6 |
| » Defeated Orioles (75-65), 9-0 | Memorial Stadium (3-4) | 64-75 | |
| » W: Bud Black (10-11) L: Curt Schilling (0-1) | Sixth | 12½ out |
| » Major-league debuts: Juan Bell and Ben McDonald (Orioles) |
| Thursday, September 7 |
| » Lost to Blue Jays (78-63), 12-4 | Cleveland Stadium (34-34) | 64-76 | |
| » W: John Cerutti (11-8) L: Tom Candiotti (12-8) | Sixth | 13½ out |
| Friday, September 8 |
| » Defeated Blue Jays (78-64), 5-4 | Cleveland Stadium (35-34) | 65-76 | |
| » W: Doug Jones (7-8) L: Jim Acker (0-7) | Sixth | 12½ out |
| Saturday, September 9 |
| » Lost to Blue Jays (79-64), 7-5 | Cleveland Stadium (35-35) | 65-77 | |
| » W: Frank Wills (2-1) L: Jeff Kaiser (0-1) | Sixth | 13½ out |
| Sunday, September 10 |
| » Lost to Blue Jays (80-64), 5-4 | Cleveland Stadium (35-36) | 65-78 | Lost 2 |
| » W: Jim Acker (1-7) L: Steve Olin (1-2) | Sixth | 14½ out |
| Tuesday, September 12 |
| » Defeated Tigers (55-91), 1-0 | Cleveland Stadium (36-36) | 66-78 | |
| » Manager: John Hart |
| » W: Bud Black (11-11) L: Frank Tanana (9-13) | Sixth | 13½ out |
| Wednesday, September 13 |
| » Lost to Tigers (56-91), 3-1 | Cleveland Stadium (36-37) | 66-79 | |
| » W: Jack Morris (6-11) L: Tom Candiotti (12-9) | Sixth | 13½ out |
| Thursday, September 14 |
| » Defeated Tigers (56-92), 4-0 | Cleveland Stadium (37-37) | 67-79 | |
| » W: Rod Nichols (4-4) L: Kevin Ritz (4-4) S: Jesse Orosco (3) | Fifth | 12½ out |
| Friday, September 15 |
| » Lost to Blue Jays (81-67), 5-2 | Skydome (0-1) | 67-80 | |
| » W: Jimmy Key (12-13) L: Greg Swindell (13-5) S: Tom Henke (17) | Fifth | |