| Monday, January 9 |
| Former Giant Bill Terry dies in Jacksonville, FL at the age of 91. |
| Sunday, February 12 |
| Former Giant Euel Moore dies in Tishomingo, OK at the age of 81. |
| Monday, April 3 |
| » Defeated Padres (0-1), 5-3 | San Diego/Jack Murphy Stadium (1-0) | 1-0 | |
| » W: Rick Reuschel (1-0) L: Eric Show (0-1) S: Mike LaCoss (1) | First | -- |
| Tuesday, April 4 |
| » Defeated Padres (0-2), 8-3 | San Diego/Jack Murphy Stadium (2-0) | 2-0 | Won 2 |
| » W: Kelly Downs (1-0) L: Bruce Hurst (0-1) | First | -- |
| Wednesday, April 5 |
| » Lost to Padres (1-2), 4-3 | San Diego/Jack Murphy Stadium (2-1) | 2-1 | |
| » W: Ed Whitson (1-0) L: Don Robinson (0-1) S: Mark Davis (1) | Second | ½ out |
| Friday, April 7 |
| » Lost to Reds (3-1), 4-3 | Riverfront Stadium (0-1) | 2-2 | Lost 2 |
| » W: Tim Birtsas (1-0) L: Joe Price (0-1) | Second | 1 out |
| Sunday, April 9 |
| » Defeated Reds (3-2), 9-1 | Riverfront Stadium (1-1) | 3-2 | |
| » W: Rick Reuschel (2-0) L: Danny Jackson (1-1) | First | -- |
| Monday, April 10 |
| » Lost to Dodgers (3-3), 7-4 | Candlestick Park (0-1) | 3-3 | |
| » W: Orel Hershiser (1-1) L: Mike LaCoss (0-1) S: Alejandro Pena (1) | Third | 1 out |
| Tuesday, April 11 |
| » Defeated Dodgers (3-4), 8-3 | Candlestick Park (1-1) | 4-3 | |
| » W: Kelly Downs (2-0) L: Tim Leary (1-1) S: Craig Lefferts (1) | Second | ½ out |
| Wednesday, April 12 |
| » Defeated Dodgers (3-5), 3-1 | Candlestick Park (2-1) | 5-3 | Won 2 |
| » W: Scott Garrelts (1-0) L: Fernando Valenzuela (0-2) S: Mike LaCoss (2) | First | -- |
| Thursday, April 13 |
| » Major-league debuts: Derek Lilliquist (Braves) |
| Friday, April 14 |
| » Defeated Braves (5-5), 7-5 | Candlestick Park (3-1) | 6-3 | Won 3 |
| » W: Rick Reuschel (3-0) L: Zane Smith (0-2) S: Craig Lefferts (2) | First | -- |
| Saturday, April 15 |
| » Defeated Braves (5-6), 1-0 | Candlestick Park (4-1) | 7-3 | Won 4 |
| » W: Atlee Hammaker (1-0) L: Pete Smith (0-2) | First | -- |
| Sunday, April 16 |
| » Lost to Braves (6-6), 7-2 | Candlestick Park (4-2) | 7-4 | |
| » W: John Smoltz (2-1) L: Kelly Downs (2-1) S: Jose Alvarez (1) | First | -- |
| » Defeated Braves (6-7), 6-1 | Candlestick Park (5-2) | 8-4 | |
| » W: Joe Price (1-1) L: Charlie Puleo (0-1) | First | -- |
| Monday, April 17 |
| » Defeated Padres (6-8), 9-0 | Candlestick Park (6-2) | 9-4 | Won 2 |
| » W: Scott Garrelts (2-0) L: Dennis Rasmussen (1-2) | First | -- |
| Tuesday, April 18 |
| » Lost to Padres (7-8), 4-2 | Candlestick Park (6-3) | 9-5 | |
| » W: Walt Terrell (1-2) L: Rick Reuschel (3-1) S: Mark Davis (6) | First | -- |
| Wednesday, April 19 |
| » Lost to Padres (8-8), 4-3 | Candlestick Park (6-4) | 9-6 | Lost 2 |
| » W: Eric Show (3-1) L: Atlee Hammaker (1-1) S: Mark Davis (7) | First | -- |
| Friday, April 21 |
| » Lost to Dodgers (8-8), 8-2 | Dodger Stadium (0-1) | 9-7 | Lost 3 |
| » W: Orel Hershiser (3-1) L: Kelly Downs (2-2) | First | -- |
| Saturday, April 22 |
| » Defeated Dodgers (8-9), 5-4 | Dodger Stadium (1-1) | 10-7 | |
| » W: Craig Lefferts (1-0) L: Jay Howell (0-2) | First | -- |
| Sunday, April 23 |
| » Lost to Dodgers (9-9), 7-6 | Dodger Stadium (1-2) | 10-8 | |
| » W: Jay Howell (1-2) L: Atlee Hammaker (1-2) | First | -- |
| Tuesday, April 25 |
| » Defeated Cardinals (8-9), 4-0 | Busch Stadium II (1-0) | 11-8 | |
| » W: Don Robinson (1-1) L: Ken Hill (1-1) S: Craig Lefferts (3) | First | -- |
| Wednesday, April 26 |
| » Lost to Cardinals (9-9), 3-1 | Busch Stadium II (1-1) | 11-9 | |
| » W: Jose DeLeon (4-1) L: Kelly Downs (2-3) S: Ken Dayley (1) | Second | ½ out |
| Thursday, April 27 |
| » Lost to Cardinals (10-9), 10-1 | Busch Stadium II (1-2) | 11-10 | Lost 2 |
| » W: Scott Terry (3-1) L: Scott Garrelts (2-1) | Third | 1 out |
| Friday, April 28 |
| » Lost to Pirates (9-13), 1-0 | Three Rivers Stadium (0-1) | 11-11 | Lost 3 |
| » W: John Smiley (2-1) L: Rick Reuschel (3-2) | Third | 2 out |
| Saturday, April 29 |
| » Defeated Pirates (9-14), 4-3 | Three Rivers Stadium (1-1) | 12-11 | |
| » W: Mike LaCoss (1-1) L: Jeff Robinson (2-3) | Third | 1 out |
| Sunday, April 30 |
| » Lost to Pirates (10-14), 11-1 | Three Rivers Stadium (1-2) | 12-12 | |
| » W: Bob Walk (2-2) L: Don Robinson (1-2) | Third | 2 out |
| Monday, May 1 |
| » Lost to Cubs (13-11), 4-3 | Candlestick Park (6-5) | 12-13 | Lost 2 |
| » W: Jeff Pico (1-0) L: Mike LaCoss (1-2) S: Calvin Schiraldi (2) | Third | 3 out |
| » Major-league debuts: Dwight Smith (Cubs) |
| Tuesday, May 2 |
| » Defeated Cubs (13-12), 4-0 | Candlestick Park (7-5) | 13-13 | |
| » W: Rick Reuschel (4-2) L: Greg Maddux (1-4) S: Rich Gossage (1) | Third | 2 out |
| » Major-league debuts: Greg Litton (Giants) |
| Wednesday, May 3 |
| » Lost to Pirates (11-16), 5-3 | Candlestick Park (7-6) | 13-14 | |
| » W: John Smiley (3-1) L: Don Robinson (1-3) S: Logan Easley (1) | Fourth | 3 out |
| Thursday, May 4 |
| » Defeated Pirates (11-17), 6-3 | Candlestick Park (8-6) | 14-14 | |
| » W: Mike Krukow (1-0) L: Randy Kramer (0-1) S: Craig Lefferts (4) | Second | 2 out |
| Friday, May 5 |
| » Lost to Cardinals (16-11), 3-1 | Candlestick Park (8-7) | 14-15 | |
| » W: Frank DiPino (1-0) L: Mike LaCoss (1-3) S: Todd Worrell (4) | Third | 2 out |
| Saturday, May 6 |
| » Defeated Cardinals (16-12), 9-0 | Candlestick Park (9-7) | 15-15 | |
| » W: Rick Reuschel (5-2) L: Jose DeLeon (5-2) S: Mike LaCoss (3) | Second | 2 out |
| Sunday, May 7 |
| » Defeated Cardinals (16-13), 5-1 | Candlestick Park (10-7) | 16-15 | Won 2 |
| » W: Don Robinson (2-3) L: Scott Terry (3-3) | Second | 1 out |
| Former Giant Howie Moss dies in Baltimore, MD at the age of 70. |
| Tuesday, May 9 |
| » Defeated Cubs (17-14), 4-2 | Wrigley Field (1-0) | 17-15 | Won 3 |
| » W: Mike Krukow (2-0) L: Paul Kilgus (3-3) S: Craig Lefferts (5) | Second | ½ out |
| Wednesday, May 10 |
| » Defeated Cubs (17-15), 4-3 | Wrigley Field (2-0) | 18-15 | Won 4 |
| » W: Mike LaCoss (2-3) L: Mitch Williams (0-2) S: Craig Lefferts (6) | First | -- |
| Friday, May 12 |
| » Defeated Expos (18-17), 2-1 | Stade Olympique (1-0) | 19-15 | Won 5 |
| » W: Rick Reuschel (6-2) L: Pascual Perez (0-5) S: Rich Gossage (2) | First | -- |
| Saturday, May 13 |
| » Lost to Expos (19-17), 5-4 | Stade Olympique (1-1) | 19-16 | |
| » W: Tim Burke (4-1) L: Atlee Hammaker (1-3) | Second | ½ out |
| Sunday, May 14 |
| » Lost to Expos (20-17), 4-3 | Stade Olympique (1-2) | 19-17 | Lost 2 |
| » W: Dennis Martinez (3-1) L: Mike Krukow (2-1) S: Tim Burke (8) | Second | 1½ out |
| Monday, May 15 |
| » Lost to Phillies (16-19), 3-2 | Veteran's Stadium (0-1) | 19-18 | Lost 3 |
| » W: Steve Bedrosian (2-2) L: Craig Lefferts (1-1) | Second | 2½ out |
| Tuesday, May 16 |
| » Defeated Phillies (16-20), 13-5 | Veteran's Stadium (1-1) | 20-18 | |
| » W: Atlee Hammaker (2-3) L: Mike Maddux (1-2) | Second | 1½ out |
| Wednesday, May 17 |
| » Defeated Phillies (16-21), 6-0 | Veteran's Stadium (2-1) | 21-18 | Won 2 |
| » W: Rick Reuschel (7-2) L: Ken Howell (4-2) | Second | 1½ out |
| Friday, May 19 |
| » Lost to Mets (22-16), 3-2 | Shea Stadium (0-1) | 21-19 | |
| » W: Randy Myers (4-1) L: Craig Lefferts (1-2) | Second | 1½ out |
| Saturday, May 20 |
| » Defeated Mets (22-17), 3-0 | Shea Stadium (1-1) | 22-19 | |
| » W: Mike Krukow (3-1) L: Bob Ojeda (1-5) S: Mike LaCoss (4) | Second | ½ out |
| Sunday, May 21 |
| » Defeated Mets (22-18), 10-6 | Shea Stadium (2-1) | 23-19 | Won 2 |
| » W: Atlee Hammaker (3-3) L: Roger McDowell (1-3) S: Craig Lefferts (7) | Second | ½ out |
| Tuesday, May 23 |
| » Defeated Expos (21-23), 4-2 | Candlestick Park (11-7) | 24-19 | Won 3 |
| » W: Rick Reuschel (8-2) L: Brian Holman (1-2) S: Mike LaCoss (5) | Second | ½ out |
| Wednesday, May 24 |
| » Lost to Expos (22-23), 1-0 | Candlestick Park (11-8) | 24-20 | |
| » W: Kevin Gross (5-3) L: Don Robinson (2-4) | Second | 1½ out |
| Thursday, May 25 |
| » Lost to Expos (23-23), 2-0 | Candlestick Park (11-9) | 24-21 | Lost 2 |
| » W: Dennis Martinez (4-1) L: Mike Krukow (3-2) S: Tim Burke (9) | Second | 2 out |
| Friday, May 26 |
| » Defeated Phillies (18-26), 6-1 | Candlestick Park (12-9) | 25-21 | |
| » W: Scott Garrelts (3-1) L: Bob Sebra (1-1) | Second | 2 out |
| Saturday, May 27 |
| » Defeated Phillies (18-27), 6-2 | Candlestick Park (13-9) | 26-21 | Won 2 |
| » W: Atlee Hammaker (4-3) L: Alex Madrid (1-2) S: Craig Lefferts (8) | Second | 1 out |
| Sunday, May 28 |
| » Defeated Phillies (18-28), 8-5 | Candlestick Park (14-9) | 27-21 | Won 3 |
| » W: Rick Reuschel (9-2) L: Ken Howell (5-3) S: Mike LaCoss (6) | Second | 1 out |
| Monday, May 29 |
| » Defeated Mets (24-23), 3-2 | Candlestick Park (15-9) | 28-21 | Won 4 |
| » W: Don Robinson (3-4) L: Ron Darling (3-4) S: Craig Lefferts (9) | First | -- |
| Tuesday, May 30 |
| » Defeated Mets (24-24), 10-3 | Candlestick Park (16-9) | 29-21 | Won 5 |
| » W: Mike Krukow (4-2) L: David Cone (3-4) | First | -- |
| Wednesday, May 31 |
| » Lost to Mets (25-24), 3-1 | Candlestick Park (16-10) | 29-22 | |
| » W: Randy Myers (5-1) L: Craig Lefferts (1-3) S: Rick Aguilera (3) | First | -- |
| Friday, June 2 |
| » Defeated Braves (22-30), 7-6 | Atlanta-Fulton County Stadium (1-0) | 30-22 | |
| » W: Rick Reuschel (10-2) L: Tom Glavine (5-2) S: Rich Gossage (3) | First | -- |
| Saturday, June 3 |
| » Defeated Braves (22-31), 4-0 | Atlanta-Fulton County Stadium (2-0) | 31-22 | Won 2 |
| » W: Atlee Hammaker (5-3) L: Zane Smith (1-8) | First | -- |
| Sunday, June 4 |
| » Lost to Braves (23-31), 6-3 | Atlanta-Fulton County Stadium (2-1) | 31-23 | |
| » W: Derek Lilliquist (4-3) L: Mike Krukow (4-3) S: Joe Boever (9) | Second | 1 out |
| Monday, June 5 |
| » Defeated Reds (30-23), 11-8 | Riverfront Stadium (2-1) | 32-23 | |
| » W: Scott Garrelts (4-1) L: Jose Rijo (5-2) | First | -- |
| Tuesday, June 6 |
| » Lost to Reds (31-23), 4-3 | Riverfront Stadium (2-2) | 32-24 | |
| » W: John Franco (2-0) L: Mike LaCoss (2-4) | First | -- |
| » Defeated Reds (31-24), 3-2 | Riverfront Stadium (3-2) | 33-24 | |
| » W: Rick Reuschel (11-2) L: Rob Dibble (4-2) S: Craig Lefferts (10) | First | -- |
| » Major-league debuts: Scott Scudder (Reds) |
| Wednesday, June 7 |
| » Lost to Reds (32-24), 12-5 | Riverfront Stadium (3-3) | 33-25 | |
| » W: Rick Mahler (8-5) L: Atlee Hammaker (5-4) | Second | 1 out |
| Thursday, June 8 |
| » Lost to Reds (33-24), 3-2 | Riverfront Stadium (3-4) | 33-26 | Lost 2 |
| » W: Rob Dibble (5-2) L: Mike LaCoss (2-5) S: John Franco (17) | Third | 1 out |
| Friday, June 9 |
| » Defeated Padres (30-32), 12-2 | Candlestick Park (17-10) | 34-26 | |
| » W: Don Robinson (4-4) L: Bruce Hurst (5-5) | Third | 1 out |
| Saturday, June 10 |
| » Defeated Padres (30-33), 1-0 | Candlestick Park (18-10) | 35-26 | Won 2 |
| » W: Scott Garrelts (5-1) L: Ed Whitson (9-3) S: Craig Lefferts (11) | Third | 1 out |
| Sunday, June 11 |
| » Defeated Padres (30-34), 3-1 | Candlestick Park (19-10) | 36-26 | Won 3 |
| » W: Rich Gossage (1-0) L: Mark Davis (2-3) | Third | 1 out |
| Tuesday, June 13 |
| » Defeated Braves (24-38), 3-2 | Candlestick Park (20-10) | 37-26 | Won 4 |
| » W: Atlee Hammaker (6-4) L: Zane Smith (1-10) S: Craig Lefferts (12) | First | -- |
| Wednesday, June 14 |
| » Defeated Braves (24-39), 10-1 | Candlestick Park (21-10) | 38-26 | Won 5 |
| » W: Don Robinson (5-4) L: Derek Lilliquist (4-4) | First | -- |
| Thursday, June 15 |
| » Lost to Braves (25-39), 2-1 | Candlestick Park (21-11) | 38-27 | |
| » W: John Smoltz (8-5) L: Scott Garrelts (5-2) | First | -- |
| Friday, June 16 |
| » Lost to Reds (37-28), 5-4 | Candlestick Park (21-12) | 38-28 | Lost 2 |
| » W: Norm Charlton (3-0) L: Rich Gossage (1-1) S: John Franco (18) | First | -- |
| Saturday, June 17 |
| » Defeated Reds (37-29), 8-1 | Candlestick Park (22-12) | 39-28 | |
| » W: Dennis Cook (1-0) L: Danny Jackson (5-9) | First | -- |
| Sunday, June 18 |
| » Defeated Reds (37-30), 2-1 | Candlestick Park (23-12) | 40-28 | Won 2 |
| » W: Mike LaCoss (3-5) L: Jose Rijo (6-4) S: Craig Lefferts (13) | First | -- |
| Monday, June 19 |
| » Defeated Astros (39-30), 3-2 | Candlestick Park (24-12) | 41-28 | Won 3 |
| » W: Don Robinson (6-4) L: Bob Knepper (3-8) S: Steve Bedrosian (7) | First | -- |
| Tuesday, June 20 |
| » Defeated Astros (39-31), 4-0 | Candlestick Park (25-12) | 42-28 | Won 4 |
| » W: Scott Garrelts (6-2) L: Bob Forsch (1-2) S: Craig Lefferts (14) | First | -- |
| Wednesday, June 21 |
| » Defeated Astros (39-32), 2-0 | Candlestick Park (26-12) | 43-28 | Won 5 |
| » W: Rick Reuschel (12-2) L: Jim Clancy (5-5) S: Steve Bedrosian (8) | First | -- |
| Friday, June 23 |
| » Defeated Padres (35-39), 8-7 | San Diego/Jack Murphy Stadium (3-1) | 44-28 | Won 6 |
| » W: Rich Gossage (2-1) L: Greg Harris (3-3) S: Steve Bedrosian (9) | First | -- |
| Saturday, June 24 |
| » Defeated Padres (35-40), 3-1 | San Diego/Jack Murphy Stadium (4-1) | 45-28 | Won 7 |
| » W: Don Robinson (7-4) L: Walt Terrell (4-10) S: Steve Bedrosian (10) | First | -- |
| Sunday, June 25 |
| » Lost to Padres (36-40), 10-7 | San Diego/Jack Murphy Stadium (4-2) | 45-29 | |
| » W: Mark Grant (2-1) L: Scott Garrelts (6-3) S: Mark Davis (19) | First | -- |
| Monday, June 26 |
| » Defeated Astros (42-33), 4-3 | Astrodome (1-0) | 46-29 | |
| » W: Craig Lefferts (2-3) L: Juan Agosto (2-3) S: Steve Bedrosian (11) | First | -- |
| Tuesday, June 27 |
| » Lost to Astros (43-33), 7-5 | Astrodome (1-1) | 46-30 | |
| » W: Danny Darwin (7-2) L: Steve Bedrosian (2-4) | First | -- |
| Wednesday, June 28 |
| » Lost to Astros (44-33), 7-3 | Astrodome (1-2) | 46-31 | Lost 2 |
| » W: Jim Deshaies (8-3) L: Don Robinson (7-5) | First | -- |
| Thursday, June 29 |
| » Defeated Cubs (40-37), 12-2 | Candlestick Park (27-12) | 47-31 | |
| » W: Jeff Brantley (1-0) L: Paul Kilgus (5-8) | First | -- |
| Friday, June 30 |
| » Lost to Cubs (41-37), 6-4 | Candlestick Park (27-13) | 47-32 | |
| » W: Scott Sanderson (7-6) L: Trevor Wilson (0-1) S: Mitch Williams (19) | First | -- |
| Saturday, July 1 |
| » Lost to Cubs (42-37), 3-2 | Candlestick Park (27-14) | 47-33 | Lost 2 |
| » W: Greg Maddux (7-7) L: Rick Reuschel (12-3) S: Mitch Williams (20) | First | -- |
| Sunday, July 2 |
| » Defeated Cubs (42-38), 4-3 | Candlestick Park (28-14) | 48-33 | |
| » W: Jeff Brantley (2-0) L: Rick Sutcliffe (9-6) S: Steve Bedrosian (12) | First | -- |
| Tuesday, July 4 |
| » Lost to Pirates (35-43), 5-3 | Three Rivers Stadium (1-3) | 48-34 | |
| » W: Randy Kramer (3-4) L: Don Robinson (7-6) S: Bill Landrum (11) | First | -- |
| Wednesday, July 5 |
| » Defeated Pirates (35-44), 6-4 | Three Rivers Stadium (2-3) | 49-34 | |
| » W: Trevor Wilson (1-1) L: Bob Walk (7-5) | First | -- |
| Thursday, July 6 |
| » Defeated Pirates (35-45), 2-1 | Three Rivers Stadium (3-3) | 50-34 | Won 2 |
| » W: Jeff Brantley (3-0) L: John Smiley (7-4) S: Craig Lefferts (15) | First | -- |
| Friday, July 7 |
| » Lost to Cardinals (43-38), 6-4 | Busch Stadium II (1-3) | 50-35 | |
| » W: Frank DiPino (5-0) L: Mike LaCoss (3-6) S: Ken Dayley (6) | First | -- |
| » Major-league debuts: Mike Benjamin (Giants) |
| Saturday, July 8 |
| » Defeated Cardinals (43-39), 8-5 | Busch Stadium II (2-3) | 51-35 | |
| » W: Jeff Brantley (4-0) L: Ted Power (1-3) | First | -- |
| Sunday, July 9 |
| » Lost to Cardinals (44-39), 6-4 | Busch Stadium II (2-4) | 51-36 | |
| » W: Joe Magrane (9-6) L: Trevor Wilson (1-2) S: Ken Dayley (7) | First | -- |
| Thursday, July 13 |
| » Defeated Pirates (36-48), 3-2 | Candlestick Park (29-14) | 52-36 | |
| » W: Jeff Brantley (5-0) L: Miguel Garcia (0-2) | First | -- |
| Friday, July 14 |
| » Lost to Pirates (37-48), 7-4 | Candlestick Park (29-15) | 52-37 | |
| » W: Doug Drabek (7-6) L: Rick Reuschel (12-4) S: Bill Landrum (12) | First | -- |
| Saturday, July 15 |
| » Defeated Pirates (37-49), 8-3 | Candlestick Park (30-15) | 53-37 | |
| » W: Mike LaCoss (4-6) L: John Smiley (7-5) | First | -- |
| Sunday, July 16 |
| » Defeated Pirates (37-50), 3-1 | Candlestick Park (31-15) | 54-37 | Won 2 |
| » W: Scott Garrelts (7-3) L: Jeff Robinson (5-8) S: Steve Bedrosian (13) | First | -- |
| Monday, July 17 |
| » Defeated Cardinals (46-42), 8-4 | Candlestick Park (32-15) | 55-37 | Won 3 |
| » W: Randy McCament (1-0) L: Ted Power (1-4) S: Rich Gossage (4) | First | -- |
| Tuesday, July 18 |
| » Defeated Cardinals (46-43), 7-3 | Candlestick Park (33-15) | 56-37 | Won 4 |
| » W: Don Robinson (8-6) L: Ken Hill (5-6) | First | -- |
| Wednesday, July 19 |
| » Defeated Cardinals (46-44), 7-5 | Candlestick Park (34-15) | 57-37 | Won 5 |
| » W: Jeff Brantley (6-0) L: Scott Terry (7-8) S: Craig Lefferts (16) | First | -- |
| Thursday, July 20 |
| » Lost to Cubs (51-43), 4-3 | Wrigley Field (2-1) | 57-38 | |
| » W: Les Lancaster (2-0) L: Randy McCament (1-1) | First | -- |
| Friday, July 21 |
| » Defeated Cubs (51-44), 4-3 | Wrigley Field (3-1) | 58-38 | |
| » W: Scott Garrelts (8-3) L: Rick Sutcliffe (10-8) S: Craig Lefferts (17) | First | -- |
| Saturday, July 22 |
| » Lost to Cubs (52-44), 5-2 | Wrigley Field (3-2) | 58-39 | |
| » W: Scott Sanderson (9-6) L: Atlee Hammaker (6-5) S: Les Lancaster (2) | First | -- |
| Sunday, July 23 |
| » Lost to Cubs (53-44), 9-5 | Wrigley Field (3-3) | 58-40 | Lost 2 |
| » W: Greg Maddux (10-8) L: Don Robinson (8-7) | First | -- |
| Monday, July 24 |
| » Defeated Braves (40-59), 2-0 | Atlanta-Fulton County Stadium (3-1) | 59-40 | |
| » W: Rick Reuschel (13-4) L: John Smoltz (11-7) S: Steve Bedrosian (14) | First | -- |
| Tuesday, July 25 |
| » Defeated Braves (40-60), 5-4 | Atlanta-Fulton County Stadium (4-1) | 60-40 | Won 2 |
| » W: Mike LaCoss (5-6) L: Derek Lilliquist (5-6) S: Craig Lefferts (18) | First | -- |
| Wednesday, July 26 |
| » Lost to Braves (41-60), 5-4 | Atlanta-Fulton County Stadium (4-2) | 60-41 | |
| » W: Joe Boever (4-3) L: Steve Bedrosian (2-5) | First | -- |
| Thursday, July 27 |
| » Lost to Braves (42-60), 10-1 | Atlanta-Fulton County Stadium (4-3) | 60-42 | Lost 2 |
| » W: Tom Glavine (9-6) L: Atlee Hammaker (6-6) | First | -- |
| Friday, July 28 |
| » Defeated Astros (58-45), 3-2 | Astrodome (2-2) | 61-42 | |
| » W: Don Robinson (9-7) L: Jim Clancy (5-8) | First | -- |
| Saturday, July 29 |
| » Lost to Astros (59-45), 8-1 | Astrodome (2-3) | 61-43 | |
| » W: Mark Portugal (2-1) L: Rick Reuschel (13-5) | First | -- |
| » Major-league debuts: Eric Anthony (Astros) |
| Sunday, July 30 |
| » Lost to Astros (60-45), 6-2 | Astrodome (2-4) | 61-44 | Lost 2 |
| » W: Mike Scott (17-5) L: Mike LaCoss (5-7) | First | -- |
| Tuesday, August 1 |
| » Defeated Dodgers (49-58), 5-2 | Dodger Stadium (2-2) | 62-44 | |
| » W: Scott Garrelts (9-3) L: Fernando Valenzuela (5-11) S: Craig Lefferts (19) | First | -- |
| Wednesday, August 2 |
| » Lost to Dodgers (50-58), 7-4 | Dodger Stadium (2-3) | 62-45 | |
| » W: Ramon Martinez (3-0) L: Trevor Wilson (1-3) S: Jay Howell (21) | First | -- |
| Thursday, August 3 |
| » Lost to Dodgers (51-58), 6-3 | Dodger Stadium (2-4) | 62-46 | Lost 2 |
| » W: Orel Hershiser (13-8) L: Russ Swan (0-1) S: Jay Howell (22) | First | -- |
| » Major-league debuts: Russ Swan (Giants) |
| Friday, August 4 |
| » Defeated Astros (61-48), 4-2 | Candlestick Park (35-15) | 63-46 | |
| » W: Don Robinson (10-7) L: Danny Darwin (10-3) | First | -- |
| Saturday, August 5 |
| » Defeated Astros (61-49), 7-0 | Candlestick Park (36-15) | 64-46 | Won 2 |
| » W: Mike LaCoss (6-7) L: Mike Scott (17-6) | First | -- |
| Sunday, August 6 |
| » Lost to Astros (62-49), 3-2 | Candlestick Park (36-16) | 64-47 | |
| » W: Juan Agosto (3-4) L: Craig Lefferts (2-4) S: Dave Smith (22) | First | -- |
| Monday, August 7 |
| » Lost to Reds (53-58), 10-2 | Candlestick Park (36-17) | 64-48 | Lost 2 |
| » W: Ron Robinson (2-1) L: Jeff Brantley (6-1) S: Tim Birtsas (1) | First | -- |
| Tuesday, August 8 |
| » Lost to Reds (54-58), 10-4 | Candlestick Park (36-18) | 64-49 | Lost 3 |
| » W: Tom Browning (10-10) L: Russ Swan (0-2) | First | -- |
| Wednesday, August 9 |
| » Defeated Reds (54-59), 10-1 | Candlestick Park (37-18) | 65-49 | |
| » W: Don Robinson (11-7) L: Rick Mahler (9-11) | First | -- |
| Thursday, August 10 |
| » Defeated Reds (54-60), 4-3 | Candlestick Park (38-18) | 66-49 | Won 2 |
| » W: Dave Dravecky (1-0) L: Scott Scudder (2-5) S: Steve Bedrosian (15) | First | -- |
| Friday, August 11 |
| » Defeated Dodgers (54-62), 10-2 | Candlestick Park (39-18) | 67-49 | Won 3 |
| » W: Mike LaCoss (7-7) L: Tim Belcher (8-11) | First | -- |
| Saturday, August 12 |
| » Lost to Dodgers (55-62), 5-1 | Candlestick Park (39-19) | 67-50 | |
| » W: Fernando Valenzuela (7-11) L: Bob Knepper (4-11) | First | -- |
| Sunday, August 13 |
| » Lost to Dodgers (56-62), 3-2 | Candlestick Park (39-20) | 67-51 | Lost 2 |
| » W: Jay Howell (3-3) L: Don Robinson (11-8) S: Alejandro Pena (3) | First | -- |
| Tuesday, August 15 |
| » Defeated Expos (65-54), 3-2 | Stade Olympique (2-2) | 68-51 | |
| » W: Dave Dravecky (2-0) L: Bryn Smith (9-7) S: Steve Bedrosian (16) | First | -- |
| Wednesday, August 16 |
| » Lost to Expos (66-54), 4-2 | Stade Olympique (2-3) | 68-52 | |
| » W: Tim Burke (7-2) L: Steve Bedrosian (2-6) | First | -- |
| » Major-league debuts: Larry Walker (Expos) |
| Thursday, August 17 |
| » Defeated Expos (66-55), 10-5 | Stade Olympique (3-3) | 69-52 | |
| » W: Bob Knepper (5-11) L: Joe Hesketh (5-4) | First | -- |
| Friday, August 18 |
| » Defeated Phillies (49-72), 5-2 | Veteran's Stadium (3-1) | 70-52 | Won 2 |
| » W: Rick Reuschel (14-5) L: Bruce Ruffin (3-7) S: Steve Bedrosian (17) | First | -- |
| Saturday, August 19 |
| » Lost to Phillies (50-72), 1-0 | Veteran's Stadium (3-2) | 70-53 | |
| » W: Terry Mulholland (3-5) L: Kelly Downs (2-4) | First | -- |
| Sunday, August 20 |
| » Defeated Phillies (50-73), 5-2 | Veteran's Stadium (4-2) | 71-53 | |
| » W: Jeff Brantley (7-1) L: Roger McDowell (3-6) | First | -- |
| Monday, August 21 |
| » Lost to Mets (69-55), 4-1 | Shea Stadium (2-2) | 71-54 | |
| » W: Ron Darling (12-9) L: Mike LaCoss (7-8) S: Randy Myers (22) | First | -- |
| Tuesday, August 22 |
| » Defeated Mets (69-56), 5-0 | Shea Stadium (3-2) | 72-54 | |
| » W: Bob Knepper (6-11) L: Frank Viola (9-15) | First | -- |
| Wednesday, August 23 |
| » Defeated Mets (69-57), 5-0 | Shea Stadium (4-2) | 73-54 | Won 2 |
| » W: Rick Reuschel (15-5) L: David Cone (11-6) | First | -- |
| Thursday, August 24 |
| » Major-league debuts: Mike Stanton (Braves) |
| Friday, August 25 |
| » Lost to Expos (70-58), 12-2 | Candlestick Park (39-21) | 73-55 | |
| » W: Dennis Martinez (14-4) L: Kelly Downs (2-5) | First | -- |
| Saturday, August 26 |
| » Defeated Expos (70-59), 8-3 | Candlestick Park (40-21) | 74-55 | |
| » W: Scott Garrelts (10-3) L: Mark Langston (14-10) | First | -- |
| Sunday, August 27 |
| » Lost to Expos (71-59), 6-3 | Candlestick Park (40-22) | 74-56 | |
| » W: Bryn Smith (10-8) L: Mike LaCoss (7-9) S: Tim Burke (26) | First | -- |
| Monday, August 28 |
| » Lost to Phillies (53-77), 9-1 | Candlestick Park (40-23) | 74-57 | Lost 2 |
| » W: Ken Howell (11-9) L: Rick Reuschel (15-6) | First | -- |
| Tuesday, August 29 |
| » Lost to Phillies (54-77), 6-1 | Candlestick Park (40-24) | 74-58 | Lost 3 |
| » W: Bruce Ruffin (4-8) L: Don Robinson (11-9) S: Roger McDowell (16) | First | -- |
| Wednesday, August 30 |
| » Defeated Phillies (54-78), 3-2 | Candlestick Park (41-24) | 75-58 | |
| » W: Kelly Downs (3-5) L: Terry Mulholland (4-6) S: Steve Bedrosian (18) | First | -- |
| Friday, September 1 |
| » Defeated Mets (72-61), 7-1 | Candlestick Park (42-24) | 76-58 | Won 2 |
| » W: Scott Garrelts (11-3) L: Ron Darling (12-11) | First | -- |
| Saturday, September 2 |
| » Defeated Mets (72-62), 6-2 | Candlestick Park (43-24) | 77-58 | Won 3 |
| » W: Rick Reuschel (16-6) L: Frank Viola (10-16) | First | -- |
| Sunday, September 3 |
| » Defeated Mets (72-63), 4-0 | Candlestick Park (44-24) | 78-58 | Won 4 |
| » W: Don Robinson (12-9) L: Bob Ojeda (10-10) | First | -- |
| Monday, September 4 |
| » Defeated Reds (66-71), 9-8 | Riverfront Stadium (4-4) | 79-58 | Won 5 |
| » W: Ernie Camacho (1-0) L: John Franco (3-7) S: Steve Bedrosian (19) | First | -- |
| Tuesday, September 5 |
| » Lost to Reds (67-71), 6-5 | Riverfront Stadium (4-5) | 79-59 | |
| » W: Jack Armstrong (2-1) L: Mike LaCoss (7-10) S: John Franco (30) | First | -- |
| Wednesday, September 6 |
| » Defeated Braves (55-84), 7-2 | Atlanta-Fulton County Stadium (5-3) | 80-59 | |
| » W: Scott Garrelts (12-3) L: Derek Lilliquist (8-9) | First | -- |
| Thursday, September 7 |
| » Defeated Braves (55-85), 7-5 | Atlanta-Fulton County Stadium (6-3) | 81-59 | Won 2 |
| » W: Steve Bedrosian (3-6) L: Mike Stanton (0-1) | First | -- |
| Friday, September 8 |
| » Lost to Astros (75-66), 5-2 | Astrodome (2-5) | 81-60 | |
| » W: Mark Portugal (4-1) L: Don Robinson (12-10) S: Danny Darwin (5) | First | -- |
| Saturday, September 9 |
| » Lost to Astros (76-66), 4-1 | Astrodome (2-6) | 81-61 | Lost 2 |
| » W: Mike Scott (19-8) L: Kelly Downs (3-6) | First | -- |
| Sunday, September 10 |
| » Defeated Astros (76-67), 5-3 | Astrodome (3-6) | 82-61 | |
| » W: Bob Knepper (7-11) L: Rick Rhoden (1-6) S: Craig Lefferts (20) | First | -- |
| Monday, September 11 |
| » Defeated Braves (56-88), 3-2 | Candlestick Park (45-24) | 83-61 | Won 2 |
| » W: Scott Garrelts (13-3) L: Tony Castillo (1-2) S: Steve Bedrosian (20) | First | -- |
| Tuesday, September 12 |
| » Lost to Braves (57-88), 6-5 | Candlestick Park (45-25) | 83-62 | |
| » W: Jay Aldrich (2-0) L: Steve Bedrosian (3-7) S: Mike Stanton (4) | First | -- |
| Wednesday, September 13 |
| » Defeated Reds (70-76), 8-7 | Candlestick Park (46-25) | 84-62 | |
| » W: Ernie Camacho (2-0) L: Rosario Rodriguez (1-1) | First | -- |
| Thursday, September 14 |
| » Defeated Reds (70-77), 4-3 | Candlestick Park (47-25) | 85-62 | Won 2 |
| » W: Ernie Camacho (3-0) L: Norm Charlton (6-2) | First | -- |
| Friday, September 15 |
| » Lost to Padres (80-68), 5-3 | Candlestick Park (47-26) | 85-63 | |
| » W: Dennis Rasmussen (9-10) L: Bob Knepper (7-12) S: Greg Harris (5) | First | -- |
| Saturday, September 16 |
| » Major-league debuts: Blaine Beatty (Mets) |
| Sunday, September 17 |
| » Defeated Padres (80-69), 5-3 | Candlestick Park (48-26) | 86-63 | |
| » W: Scott Garrelts (14-3) L: Greg Harris (6-8) S: Steve Bedrosian (21) | First | -- |
| » Lost to Padres (81-69), 6-1 | Candlestick Park (48-27) | 86-64 | |
| » W: Bruce Hurst (15-10) L: Rick Reuschel (16-7) | First | -- |
| Tuesday, September 19 |
| » Defeated Dodgers (72-79), 3-2 | Candlestick Park (49-27) | 87-64 | |
| » W: Mike LaCoss (8-10) L: Orel Hershiser (14-14) S: Steve Bedrosian (22)< |
