| Friday, February 24 |
| Former Cub Sparky Adams dies in Pottsville, PA at the age of 95. |
| Monday, April 3 |
| » Major-league debuts: Omar Vizquel (Mariners) |
| Tuesday, April 4 |
| » Defeated Phillies (0-1), 5-4 | Wrigley Field (1-0) | 1-0 | |
| » W: Rick Sutcliffe (1-0) L: Floyd Youmans (0-1) S: Mitch Williams (1) | First | -- |
| » Major-league debuts: Joe Girardi and Jerome Walton (Cubs) |
| Wednesday, April 5 |
| » Lost to Phillies (1-1), 12-4 | Wrigley Field (1-1) | 1-1 | |
| » W: Ken Howell (1-0) L: Greg Maddux (0-1) S: Mike Maddux (1) | First | -- |
| » Major-league debuts: Phil Stephenson (Cubs) |
| Thursday, April 6 |
| » Lost to Phillies (2-1), 8-3 | Wrigley Field (1-2) | 1-2 | Lost 2 |
| » W: Steve Ontiveros (1-0) L: Paul Kilgus (0-1) | Third | 1 out |
| Friday, April 7 |
| » Defeated Pirates (1-3), 6-5 | Wrigley Field (2-2) | 2-2 | |
| » W: Steve Wilson (1-0) L: Dorn Taylor (0-1) S: Mitch Williams (2) | Fourth | 1 out |
| Saturday, April 8 |
| » Defeated Pirates (1-4), 5-3 | Wrigley Field (3-2) | 3-2 | Won 2 |
| » W: Mike Bielecki (1-0) L: Neal Heaton (0-1) S: Calvin Schiraldi (1) | Third | 1 out |
| Sunday, April 9 |
| » Defeated Pirates (1-5), 8-3 | Wrigley Field (4-2) | 4-2 | Won 3 |
| » W: Rick Sutcliffe (2-0) L: Bob Walk (0-1) | First | -- |
| Tuesday, April 11 |
| » Defeated Cardinals (2-3), 5-4 | Wrigley Field (5-2) | 5-2 | Won 4 |
| » W: Calvin Schiraldi (1-0) L: Jose DeLeon (1-1) S: Mitch Williams (3) | First | -- |
| Wednesday, April 12 |
| » Defeated Cardinals (2-4), 3-2 | Wrigley Field (6-2) | 6-2 | Won 5 |
| » W: Paul Kilgus (1-1) L: Scott Terry (0-1) S: Mitch Williams (4) | First | -- |
| Friday, April 14 |
| » Defeated Phillies (6-3), 6-4 | Veteran's Stadium (1-0) | 7-2 | Won 6 |
| » W: Scott Sanderson (1-0) L: Bruce Ruffin (0-2) S: Mitch Williams (5) | First | -- |
| Saturday, April 15 |
| » Major-league debuts: Kent Anderson (Angels) |
| Sunday, April 16 |
| » Defeated Phillies (6-4), 5-3 | Veteran's Stadium (2-0) | 8-2 | Won 7 |
| » W: Rick Sutcliffe (3-0) L: Floyd Youmans (0-2) S: Mitch Williams (6) | First | -- |
| Monday, April 17 |
| » Lost to Expos (7-6), 2-1 | Stade Olympique (0-1) | 8-3 | |
| » W: Kevin Gross (2-1) L: Greg Maddux (0-2) S: Tim Burke (3) | First | -- |
| Tuesday, April 18 |
| » Lost to Expos (8-6), 11-2 | Stade Olympique (0-2) | 8-4 | Lost 2 |
| » W: Bryn Smith (1-0) L: Paul Kilgus (1-2) | First | -- |
| Wednesday, April 19 |
| » Lost to Expos (9-6), 3-2 | Stade Olympique (0-3) | 8-5 | Lost 3 |
| » W: Dennis Martinez (1-0) L: Scott Sanderson (1-1) S: Tim Burke (4) | First | -- |
| Thursday, April 20 |
| » Lost to Mets (6-8), 4-3 | Shea Stadium (0-1) | 8-6 | Lost 4 |
| » W: Dwight Gooden (3-0) L: Mitch Williams (0-1) S: Roger McDowell (1) | First | -- |
| Friday, April 21 |
| » Defeated Mets (6-9), 8-4 | Shea Stadium (1-1) | 9-6 | |
| » W: Rick Sutcliffe (4-0) L: Bob Ojeda (0-3) S: Steve Wilson (1) | First | -- |
| Saturday, April 22 |
| » Lost to Mets (7-9), 3-1 | Shea Stadium (1-2) | 9-7 | |
| » W: Sid Fernandez (2-0) L: Greg Maddux (0-3) S: Roger McDowell (2) | First | -- |
| Sunday, April 23 |
| » Lost to Mets (8-9), 4-2 | Shea Stadium (1-3) | 9-8 | Lost 2 |
| » W: Rick Aguilera (1-0) L: Calvin Schiraldi (1-1) | First | -- |
| Tuesday, April 25 |
| » Lost to Dodgers (10-9), 4-0 | Wrigley Field (6-3) | 9-9 | Lost 3 |
| » W: Tim Belcher (2-1) L: Scott Sanderson (1-2) | Second | ½ out |
| Wednesday, April 26 |
| » Lost to Dodgers (11-9), 3-1 | Wrigley Field (6-4) | 9-10 | Lost 4 |
| » W: Mike Morgan (2-1) L: Rick Sutcliffe (4-1) S: Jay Howell (2) | Fifth | 1 out |
| Thursday, April 27 |
| » Defeated Dodgers (11-10), 1-0 | Wrigley Field (7-4) | 10-10 | |
| » W: Greg Maddux (1-3) L: Orel Hershiser (3-2) | Second | ½ out |
| Friday, April 28 |
| » Defeated Padres (13-11), 3-1 | Wrigley Field (8-4) | 11-10 | Won 2 |
| » W: Paul Kilgus (2-2) L: Dennis Rasmussen (1-4) S: Mitch Williams (7) | Second | ½ out |
| Saturday, April 29 |
| » Lost to Padres (14-11), 5-4 | Wrigley Field (8-5) | 11-11 | |
| » W: Walt Terrell (3-2) L: Mike Bielecki (1-1) S: Mark Davis (11) | Third | 1½ out |
| Sunday, April 30 |
| » Defeated Padres (14-12), 7-3 | Wrigley Field (9-5) | 12-11 | |
| » W: Scott Sanderson (2-2) L: Eric Show (4-2) | Fourth | 1½ out |
| Monday, May 1 |
| » Defeated Giants (12-13), 4-3 | Candlestick Park (1-0) | 13-11 | Won 2 |
| » W: Jeff Pico (1-0) L: Mike LaCoss (1-2) S: Calvin Schiraldi (2) | Third | 1½ out |
| » Major-league debuts: Dwight Smith (Cubs) |
| Tuesday, May 2 |
| » Lost to Giants (13-13), 4-0 | Candlestick Park (1-1) | 13-12 | |
| » W: Rick Reuschel (4-2) L: Greg Maddux (1-4) S: Rich Gossage (1) | Third | 1½ out |
| » Major-league debuts: Greg Litton (Giants) |
| Wednesday, May 3 |
| » Defeated Padres (15-14), 5-4 | San Diego/Jack Murphy Stadium (1-0) | 14-12 | |
| » W: Paul Kilgus (3-2) L: Mark Grant (0-1) S: Mitch Williams (8) | Third | ½ out |
| Thursday, May 4 |
| » Defeated Padres (15-15), 4-0 | San Diego/Jack Murphy Stadium (2-0) | 15-12 | Won 2 |
| » W: Mike Bielecki (2-1) L: Walt Terrell (3-3) | Second | ½ out |
| Friday, May 5 |
| » Defeated Dodgers (14-15), 4-2 | Dodger Stadium (1-0) | 16-12 | Won 3 |
| » W: Scott Sanderson (3-2) L: Tim Belcher (2-3) S: Mitch Williams (9) | Third | ½ out |
| Saturday, May 6 |
| » Lost to Dodgers (15-15), 3-0 | Dodger Stadium (1-1) | 16-13 | |
| » W: Mike Morgan (3-1) L: Rick Sutcliffe (4-2) S: Jay Howell (3) | Third | 1 out |
| Sunday, May 7 |
| » Defeated Dodgers (15-16), 4-2 | Dodger Stadium (2-1) | 17-13 | |
| » W: Steve Wilson (2-0) L: Orel Hershiser (4-3) S: Mitch Williams (10) | Second | 1 out |
| Tuesday, May 9 |
| » Lost to Giants (17-15), 4-2 | Wrigley Field (9-6) | 17-14 | |
| » W: Mike Krukow (2-0) L: Paul Kilgus (3-3) S: Craig Lefferts (5) | Second | ½ out |
| Wednesday, May 10 |
| » Lost to Giants (18-15), 4-3 | Wrigley Field (9-7) | 17-15 | Lost 2 |
| » W: Mike LaCoss (2-3) L: Mitch Williams (0-2) S: Craig Lefferts (6) | Second | 1½ out |
| Friday, May 12 |
| » Lost to Astros (15-19), 3-1 | Wrigley Field (9-8) | 17-16 | Lost 3 |
| » W: Jim Deshaies (5-2) L: Rick Sutcliffe (4-3) | Third | 2 out |
| Saturday, May 13 |
| » Lost to Astros (16-19), 1-0 | Wrigley Field (9-9) | 17-17 | Lost 4 |
| » W: Bob Knepper (2-5) L: Greg Maddux (1-5) S: Dave Smith (6) | Fourth | 2½ out |
| Sunday, May 14 |
| » Lost to Astros (17-19), 5-1 | Wrigley Field (9-10) | 17-18 | Lost 5 |
| » W: Mike Scott (5-2) L: Paul Kilgus (3-4) | Fourth | 3½ out |
| Monday, May 15 |
| » Defeated Braves (18-20), 4-0 | Wrigley Field (10-10) | 18-18 | |
| » W: Mike Bielecki (3-1) L: Derek Lilliquist (2-3) | Fourth | 2½ out |
| Tuesday, May 16 |
| » Defeated Braves (18-21), 4-3 | Wrigley Field (11-10) | 19-18 | Won 2 |
| » W: Scott Sanderson (4-2) L: Tom Glavine (5-1) S: Mitch Williams (11) | Third | 2 out |
| Wednesday, May 17 |
| » Defeated Braves (18-22), 4-0 | Wrigley Field (12-10) | 20-18 | Won 3 |
| » W: Jeff Pico (2-0) L: Zane Smith (1-6) | Second | 1 out |
| Friday, May 19 |
| » Defeated Reds (22-17), 8-2 | Riverfront Stadium (1-0) | 21-18 | Won 4 |
| » W: Greg Maddux (2-5) L: Danny Jackson (2-7) | Second | 1½ out |
| Saturday, May 20 |
| » Defeated Reds (22-18), 7-3 | Riverfront Stadium (2-0) | 22-18 | Won 5 |
| » W: Paul Kilgus (4-4) L: Tom Browning (3-4) S: Pat Perry (1) | Second | ½ out |
| Sunday, May 21 |
| » Lost to Reds (23-18), 7-2 | Riverfront Stadium (2-1) | 22-19 | |
| » W: Rick Mahler (6-4) L: Mike Bielecki (3-2) | Second | ½ out |
| Monday, May 22 |
| » Defeated Astros (21-22), 5-3 | Astrodome (1-0) | 23-19 | |
| » W: Rick Sutcliffe (5-3) L: Jim Deshaies (5-3) S: Calvin Schiraldi (3) | Second | 1 out |
| Tuesday, May 23 |
| » Defeated Astros (21-23), 5-4 | Astrodome (2-0) | 24-19 | Won 2 |
| » W: Scott Sanderson (5-2) L: Mike Scott (6-3) S: Calvin Schiraldi (4) | First | -- |
| Wednesday, May 24 |
| » Defeated Astros (21-24), 3-1 | Astrodome (3-0) | 25-19 | Won 3 |
| » W: Greg Maddux (3-5) L: Bob Knepper (2-6) S: Mitch Williams (12) | First | -- |
| Friday, May 26 |
| » Lost to Reds (26-18), 10-8 | Wrigley Field (12-11) | 25-20 | |
| » W: Rob Dibble (4-1) L: Calvin Schiraldi (1-2) | First | -- |
| Saturday, May 27 |
| » Defeated Reds (26-19), 5-3 | Wrigley Field (13-11) | 26-20 | |
| » W: Rick Sutcliffe (6-3) L: Jose Rijo (4-1) | First | -- |
| Sunday, May 28 |
| » Defeated Reds (26-20), 6-1 | Wrigley Field (14-11) | 27-20 | Won 2 |
| » W: Mike Bielecki (4-2) L: Danny Jackson (3-8) | First | -- |
| Monday, May 29 |
| » Lost to Braves (21-28), 2-1 | Atlanta-Fulton County Stadium (0-1) | 27-21 | |
| » W: Derek Lilliquist (3-3) L: Scott Sanderson (5-3) S: Joe Boever (7) | First | -- |
| Tuesday, May 30 |
| » Defeated Braves (21-29), 3-2 | Atlanta-Fulton County Stadium (1-1) | 28-21 | |
| » W: Greg Maddux (4-5) L: Pete Smith (1-7) S: Mitch Williams (13) | First | -- |
| Wednesday, May 31 |
| » Lost to Braves (22-29), 3-2 | Atlanta-Fulton County Stadium (1-2) | 28-22 | |
| » W: John Smoltz (7-3) L: Paul Kilgus (4-5) S: Joe Boever (8) | First | -- |
| Friday, June 2 |
| » Defeated Cardinals (23-26), 5-2 | Busch Stadium II (1-0) | 29-22 | |
| » W: Rick Sutcliffe (7-3) L: Joe Magrane (3-4) S: Mitch Williams (14) | First | -- |
| Saturday, June 3 |
| » Lost to Cardinals (24-26), 6-5 | Busch Stadium II (1-1) | 29-23 | |
| » W: Dan Quisenberry (2-1) L: Calvin Schiraldi (1-3) | First | -- |
| Sunday, June 4 |
| » Defeated Cardinals (24-27), 11-3 | Busch Stadium II (2-1) | 30-23 | |
| » W: Scott Sanderson (6-3) L: Scott Terry (4-5) | First | -- |
| Monday, June 5 |
| » Defeated Mets (28-25), 15-3 | Wrigley Field (15-11) | 31-23 | Won 2 |
| » W: Greg Maddux (5-5) L: David Cone (3-5) | First | -- |
| Tuesday, June 6 |
| » Defeated Mets (28-26), 8-4 | Wrigley Field (16-11) | 32-23 | Won 3 |
| » W: Paul Kilgus (5-5) L: Bob Ojeda (2-6) | First | -- |
| » Major-league debuts: Jeff McKnight (Mets) |
| Wednesday, June 7 |
| » Lost to Mets (29-26), 10-5 | Wrigley Field (16-12) | 32-24 | |
| » W: Dwight Gooden (7-2) L: Rick Sutcliffe (7-4) S: Rick Aguilera (4) | First | -- |
| Thursday, June 8 |
| » Defeated Mets (29-27), 5-4 | Wrigley Field (17-12) | 33-24 | |
| » W: Mitch Williams (1-2) L: Don Aase (1-2) | First | -- |
| Former Cub Emil Verban dies in Quincy, IL at the age of 74. |
| Friday, June 9 |
| » Lost to Cardinals (28-28), 1-0 | Wrigley Field (17-13) | 33-25 | |
| » W: Jose DeLeon (8-3) L: Scott Sanderson (6-4) S: Todd Worrell (7) | First | -- |
| Saturday, June 10 |
| » Lost to Cardinals (29-28), 6-0 | Wrigley Field (17-14) | 33-26 | Lost 2 |
| » W: Joe Magrane (4-5) L: Greg Maddux (5-6) | First | -- |
| Sunday, June 11 |
| » Lost to Cardinals (30-28), 10-7 | Wrigley Field (17-15) | 33-27 | Lost 3 |
| » W: Cris Carpenter (2-4) L: Calvin Schiraldi (1-4) | First | -- |
| Monday, June 12 |
| » Defeated Cardinals (30-29), 10-3 | Wrigley Field (18-15) | 34-27 | |
| » W: Steve Wilson (3-0) L: Scott Terry (4-6) | First | -- |
| Tuesday, June 13 |
| » Defeated Mets (30-30), 4-2 | Shea Stadium (2-3) | 35-27 | Won 2 |
| » W: Mike Bielecki (5-2) L: Ron Darling (4-5) S: Mitch Williams (15) | First | -- |
| Wednesday, June 14 |
| » Lost to Mets (31-30), 2-0 | Shea Stadium (2-4) | 35-28 | |
| » W: Dwight Gooden (8-2) L: Scott Sanderson (6-5) S: Rick Aguilera (5) | First | -- |
| Thursday, June 15 |
| » Lost to Mets (32-30), 4-3 | Shea Stadium (2-5) | 35-29 | Lost 2 |
| » W: Rick Aguilera (3-1) L: Pat Perry (0-1) | First | -- |
| Friday, June 16 |
| » Lost to Expos (36-30), 8-5 | Stade Olympique (0-4) | 35-30 | Lost 3 |
| » W: Bryn Smith (7-2) L: Paul Kilgus (5-6) S: Tim Burke (14) | Second | ½ out |
| Saturday, June 17 |
| » Defeated Expos (36-31), 3-2 | Stade Olympique (1-4) | 36-30 | |
| » W: Rick Sutcliffe (8-4) L: Pascual Perez (3-8) S: Mitch Williams (16) | First | -- |
| Sunday, June 18 |
| » Defeated Expos (36-32), 5-4 | Stade Olympique (2-4) | 37-30 | Won 2 |
| » W: Mike Bielecki (6-2) L: Mark Langston (6-7) S: Mitch Williams (17) | First | -- |
| Tuesday, June 20 |
| » Defeated Pirates (27-38), 5-4 | Three Rivers Stadium (1-0) | 38-30 | Won 3 |
| » W: Calvin Schiraldi (2-4) L: Miguel Garcia (0-1) S: Paul Kilgus (1) | First | -- |
| Wednesday, June 21 |
| » Defeated Pirates (27-39), 1-0 | Three Rivers Stadium (2-0) | 39-30 | Won 4 |
| » W: Greg Maddux (6-6) L: Doug Bair (0-1) S: Mitch Williams (18) | First | -- |
| Thursday, June 22 |
| » Defeated Pirates (27-40), 8-0 | Three Rivers Stadium (3-0) | 40-30 | Won 5 |
| » W: Rick Sutcliffe (9-4) L: Randy Kramer (1-4) | First | -- |
| Friday, June 23 |
| » Lost to Expos (38-34), 5-1 | Wrigley Field (18-16) | 40-31 | |
| » W: Mark Langston (7-7) L: Mike Bielecki (6-3) S: Tim Burke (15) | First | -- |
| Saturday, June 24 |
| » Lost to Expos (39-34), 5-0 | Wrigley Field (18-17) | 40-32 | Lost 2 |
| » W: Kevin Gross (7-6) L: Paul Kilgus (5-7) | First | -- |
| Sunday, June 25 |
| » Lost to Expos (40-34), 5-0 | Wrigley Field (18-18) | 40-33 | Lost 3 |
| » W: Dennis Martinez (7-1) L: Scott Sanderson (6-6) | Second | 1 out |
| Monday, June 26 |
| » Lost to Pirates (30-41), 2-1 | Wrigley Field (18-19) | 40-34 | Lost 4 |
| » W: Doug Drabek (5-5) L: Greg Maddux (6-7) | Third | ½ out |
| Tuesday, June 27 |
| » Lost to Pirates (31-41), 5-4 | Wrigley Field (18-20) | 40-35 | Lost 5 |
| » W: Randy Kramer (2-4) L: Rick Sutcliffe (9-5) S: Bill Landrum (7) | Third | 1½ out |
| Wednesday, June 28 |
| » Lost to Pirates (32-41), 3-1 | Wrigley Field (18-21) | 40-36 | Lost 6 |
| » W: Jeff Robinson (4-6) L: Mike Bielecki (6-4) S: Bill Landrum (8) | Third | 2½ out |
| Thursday, June 29 |
| » Lost to Giants (47-31), 12-2 | Candlestick Park (1-2) | 40-37 | Lost 7 |
| » W: Jeff Brantley (1-0) L: Paul Kilgus (5-8) | Third | 2½ out |
| Friday, June 30 |
| » Defeated Giants (47-32), 6-4 | Candlestick Park (2-2) | 41-37 | |
| » W: Scott Sanderson (7-6) L: Trevor Wilson (0-1) S: Mitch Williams (19) | Third | 2½ out |
| Saturday, July 1 |
| » Defeated Giants (47-33), 3-2 | Candlestick Park (3-2) | 42-37 | Won 2 |
| » W: Greg Maddux (7-7) L: Rick Reuschel (12-3) S: Mitch Williams (20) | Second | 1½ out |
| Sunday, July 2 |
| » Lost to Giants (48-33), 4-3 | Candlestick Park (3-3) | 42-38 | |
| » W: Jeff Brantley (2-0) L: Rick Sutcliffe (9-6) S: Steve Bedrosian (12) | Third | 2½ out |
| Tuesday, July 4 |
| » Defeated Padres (40-43), 5-1 | Wrigley Field (19-21) | 43-38 | |
| » W: Mike Bielecki (7-4) L: Ed Whitson (10-6) S: Steve Wilson (2) | Third | 2 out |
| Wednesday, July 5 |
| » Defeated Padres (40-44), 5-3 | Wrigley Field (20-21) | 44-38 | Won 2 |
| » W: Scott Sanderson (8-6) L: Dennis Rasmussen (3-6) S: Paul Kilgus (2) | Second | 2 out |
| Thursday, July 6 |
| » Defeated Padres (40-45), 7-3 | Wrigley Field (21-21) | 45-38 | Won 3 |
| » W: Greg Maddux (8-7) L: Walt Terrell (4-12) S: Mitch Williams (21) | Second | 1½ out |
| Friday, July 7 |
| » Defeated Dodgers (39-46), 6-4 | Wrigley Field (22-21) | 46-38 | Won 4 |
| » W: Rick Sutcliffe (10-6) L: John Wetteland (2-2) S: Mitch Williams (22) | Second | 1½ out |
| Saturday, July 8 |
| » Lost to Dodgers (40-46), 8-2 | Wrigley Field (22-22) | 46-39 | |
| » W: Mike Morgan (6-8) L: Jeff Pico (2-1) | Second | 1½ out |
| Sunday, July 9 |
| » Defeated Dodgers (40-47), 11-4 | Wrigley Field (23-22) | 47-39 | |
| » W: Mike Bielecki (8-4) L: Fernando Valenzuela (4-8) | Second | 1½ out |
| Thursday, July 13 |
| » Defeated Padres (42-47), 7-3 | San Diego/Jack Murphy Stadium (3-0) | 48-39 | Won 2 |
| » W: Greg Maddux (9-7) L: Bruce Hurst (7-7) S: Les Lancaster (1) | Second | 1½ out |
| Former Cub Vern Olsen dies in Maywood, IL at the age of 72. |
| Friday, July 14 |
| » Lost to Padres (43-47), 7-4 | San Diego/Jack Murphy Stadium (3-1) | 48-40 | |
| » W: Ed Whitson (12-6) L: Mike Bielecki (8-5) S: Mark Davis (23) | Second | 2½ out |
| Saturday, July 15 |
| » Lost to Padres (44-47), 3-2 | San Diego/Jack Murphy Stadium (3-2) | 48-41 | Lost 2 |
| » W: Walt Terrell (5-12) L: Paul Kilgus (5-9) | Third | 2½ out |
| Sunday, July 16 |
| » Lost to Padres (45-47), 4-3 | San Diego/Jack Murphy Stadium (3-3) | 48-42 | Lost 3 |
| » W: Dennis Rasmussen (4-6) L: Rick Sutcliffe (10-7) S: Mark Davis (24) | Third | 3½ out |
| Monday, July 17 |
| » Defeated Dodgers (42-50), 6-3 | Dodger Stadium (3-1) | 49-42 | |
| » W: Les Lancaster (1-0) L: Tim Leary (6-7) S: Mitch Williams (23) | Second | 3½ out |
| Tuesday, July 18 |
| » Lost to Dodgers (43-50), 4-1 | Dodger Stadium (3-2) | 49-43 | |
| » W: Orel Hershiser (11-7) L: Greg Maddux (9-8) | Second | 3½ out |
| Former Cub Donnie Moore dies in Anaheim, CA at the age of 36. |
| Wednesday, July 19 |
| » Defeated Dodgers (43-51), 4-0 | Dodger Stadium (4-2) | 50-43 | |
| » W: Mike Bielecki (9-5) L: Mike Morgan (6-10) | Second | 2½ out |
| Thursday, July 20 |
| » Defeated Giants (57-38), 4-3 | Wrigley Field (24-22) | 51-43 | Won 2 |
| » W: Les Lancaster (2-0) L: Randy McCament (1-1) | Second | 2½ out |
| Friday, July 21 |
| » Lost to Giants (58-38), 4-3 | Wrigley Field (24-23) | 51-44 | |
| » W: Scott Garrelts (8-3) L: Rick Sutcliffe (10-8) S: Craig Lefferts (17) | Third | 3½ out |
| Saturday, July 22 |
| » Defeated Giants (58-39), 5-2 | Wrigley Field (25-23) | 52-44 | |
| » W: Scott Sanderson (9-6) L: Atlee Hammaker (6-5) S: Les Lancaster (2) | Third | 3½ out |
| Sunday, July 23 |
| » Defeated Giants (58-40), 9-5 | Wrigley Field (26-23) | 53-44 | Won 2 |
| » W: Greg Maddux (10-8) L: Don Robinson (8-7) | Third | 3½ out |
| Monday, July 24 |
| » Defeated Cardinals (50-45), 3-2 | Busch Stadium II (3-1) | 54-44 | Won 3 |
| » W: Mike Bielecki (10-5) L: Scott Terry (7-9) S: Mitch Williams (24) | Third | 3½ out |
| Tuesday, July 25 |
| » Defeated Cardinals (50-46), 4-2 | Busch Stadium II (4-1) | 55-44 | Won 4 |
| » W: Paul Kilgus (6-9) L: Joe Magrane (11-7) S: Mitch Williams (25) | Second | 3½ out |
| Wednesday, July 26 |
| » Lost to Cardinals (51-46), 2-0 | Busch Stadium II (4-2) | 55-45 | |
| » W: Jose DeLeon (10-9) L: Rick Sutcliffe (10-9) S: Todd Worrell (13) | Second | 3½ out |
| Friday, July 28 |
| » Defeated Mets (53-47), 6-5 | Wrigley Field (27-23) | 56-45 | |
| » W: Calvin Schiraldi (3-4) L: Rick Aguilera (6-5) S: Mitch Williams (26) | Second | 2½ out |
| Saturday, July 29 |
| » Defeated Mets (53-48), 10-3 | Wrigley Field (28-23) | 57-45 | Won 2 |
| » W: Greg Maddux (11-8) L: Wally Whitehurst (0-1) | Second | 2½ out |
| Sunday, July 30 |
| » Defeated Mets (53-49), 6-4 | Wrigley Field (29-23) | 58-45 | Won 3 |
| » W: Les Lancaster (3-0) L: Rick Aguilera (6-6) | Second | 1½ out |
| Monday, July 31 |
| » Defeated Phillies (41-62), 10-2 | Veteran's Stadium (3-0) | 59-45 | Won 4 |
| » W: Rick Sutcliffe (11-9) L: Terry Mulholland (1-5) | Second | 2 out |
| » Lost to Phillies (42-62), 7-4 | Veteran's Stadium (3-1) | 59-46 | |
| » W: Don Carman (3-11) L: Paul Kilgus (6-10) S: Jeff Parrett (4) | Second | 2 out |
| Tuesday, August 1 |
| » Defeated Phillies (42-63), 4-1 | Veteran's Stadium (4-1) | 60-46 | |
| » W: Steve Wilson (4-0) L: Larry McWilliams (2-11) S: Mitch Williams (27) | Second | 2 out |
| Wednesday, August 2 |
| » Lost to Phillies (43-63), 6-0 | Veteran's Stadium (4-2) | 60-47 | |
| » W: Ken Howell (9-7) L: Scott Sanderson (9-7) | Second | 3 out |
| Thursday, August 3 |
| » Defeated Phillies (43-64), 2-0 | Veteran's Stadium (5-2) | 61-47 | |
| » W: Greg Maddux (12-8) L: Bruce Ruffin (3-5) S: Les Lancaster (3) | Second | 2 out |
| Friday, August 4 |
| » Defeated Pirates (46-62), 3-2 | Three Rivers Stadium (4-0) | 62-47 | Won 2 |
| » W: Mike Bielecki (11-5) L: Doug Drabek (8-8) S: Mitch Williams (28) | Second | 1 out |
| Saturday, August 5 |
| » Defeated Pirates (46-63), 4-2 | Three Rivers Stadium (5-0) | 63-47 | Won 3 |
| » W: Steve Wilson (5-0) L: Bill Landrum (2-2) S: Les Lancaster (4) | First | -- |
| Sunday, August 6 |
| » Lost to Pirates (47-63), 5-4 | Three Rivers Stadium (5-1) | 63-48 | |
| » W: Doug Drabek (9-8) L: Scott Sanderson (9-8) | First | -- |
| Monday, August 7 |
| » Defeated Expos (63-49), 5-2 | Wrigley Field (30-23) | 64-48 | |
| » W: Greg Maddux (13-8) L: Pascual Perez (6-11) | First | -- |
| Tuesday, August 8 |
| » Defeated Expos (63-50), 4-2 | Wrigley Field (31-23) | 65-48 | Won 2 |
| » W: Mike Bielecki (12-5) L: Dennis Martinez (12-2) S: Les Lancaster (5) | First | -- |
| Wednesday, August 9 |
| » Defeated Expos (63-51), 3-0 | Wrigley Field (32-23) | 66-48 | Won 3 |
| » W: Rick Sutcliffe (12-9) L: Bryn Smith (9-6) S: Mitch Williams (29) | First | -- |
| Thursday, August 10 |
| » Lost to Phillies (46-68), 16-13 | Wrigley Field (32-24) | 66-49 | |
| » W: Jeff Parrett (9-4) L: Steve Wilson (5-1) | First | -- |
| Friday, August 11 |
| » Defeated Phillies (46-69), 9-2 | Wrigley Field (33-24) | 67-49 | |
| » W: Greg Maddux (14-8) L: Don Carman (3-12) | First | -- |
| Saturday, August 12 |
| » Defeated Phillies (46-70), 9-7 | Wrigley Field (34-24) | 68-49 | Won 2 |
| » W: Mike Bielecki (13-5) L: Ken Howell (9-8) S: Mitch Williams (30) | First | -- |
| Sunday, August 13 |
| » Lost to Phillies (47-70), 5-3 | Wrigley Field (34-25) | 68-50 | |
| » W: Jeff Parrett (10-4) L: Steve Wilson (5-2) | First | -- |
| Tuesday, August 15 |
| » Defeated Reds (56-62), 5-2 | Riverfront Stadium (3-1) | 69-50 | |
| » W: Mitch Williams (2-2) L: Mike Roesler (0-1) | First | -- |
| Wednesday, August 16 |
| » Defeated Reds (56-63), 5-1 | Riverfront Stadium (4-1) | 70-50 | Won 2 |
| » W: Mike Bielecki (14-5) L: Tim Leary (8-10) | First | -- |
| Thursday, August 17 |
| » Defeated Reds (56-64), 3-2 | Riverfront Stadium (5-1) | 71-50 | Won 3 |
| » W: Rick Sutcliffe (13-9) L: John Franco (3-6) S: Mitch Williams (31) | First | -- |
| Friday, August 18 |
| » Lost to Astros (67-55), 6-5 | Astrodome (3-1) | 71-51 | |
| » W: Dave Smith (3-3) L: Calvin Schiraldi (3-5) | First | -- |
| Saturday, August 19 |
| » Lost to Astros (68-55), 8-4 | Astrodome (3-2) | 71-52 | Lost 2 |
| » W: Mark Portugal (3-1) L: Greg Maddux (14-9) | First | -- |
| Sunday, August 20 |
| » Lost to Astros (69-55), 8-4 | Astrodome (3-3) | 71-53 | Lost 3 |
| » W: Danny Darwin (11-3) L: Les Lancaster (3-1) | First | -- |
| Monday, August 21 |
| » Lost to Reds (59-66), 6-5 | Wrigley Field (34-26) | 71-54 | Lost 4 |
| » W: Norm Charlton (6-1) L: Calvin Schiraldi (3-6) S: John Franco (26) | First | -- |
| Tuesday, August 22 |
| » Lost to Reds (60-66), 7-2 | Wrigley Field (34-27) | 71-55 | Lost 5 |
| » W: Tom Browning (13-10) L: Joe Kraemer (0-1) | First | -- |
| Wednesday, August 23 |
| » Lost to Reds (61-66), 8-5 | Wrigley Field (34-28) | 71-56 | Lost 6 |
| » W: Scott Scudder (3-5) L: Greg Maddux (14-10) | First | -- |
| Friday, August 25 |
| » Defeated Braves (51-77), 4-3 | Wrigley Field (35-28) | 72-56 | |
| » W: Mitch Williams (3-2) L: Mark Eichhorn (4-4) | First | -- |
| Saturday, August 26 |
| » Lost to Braves (52-77), 5-3 | Wrigley Field (35-29) | 72-57 | |
| » W: Sergio Valdez (1-2) L: Rick Sutcliffe (13-10) S: Joe Boever (21) | First | -- |
| Sunday, August 27 |
| » Defeated Braves (52-78), 3-2 | Wrigley Field (36-29) | 73-57 | |
| » W: Mitch Williams (4-2) L: Mark Eichhorn (4-5) | First | -- |
| Monday, August 28 |
| » Defeated Astros (70-61), 6-1 | Wrigley Field (37-29) | 74-57 | Won 2 |
| » W: Greg Maddux (15-10) L: Jose Cano (0-1) | First | -- |
| Tuesday, August 29 |
| » Defeated Astros (70-62), 10-9 | Wrigley Field (38-29) | 75-57 | Won 3 |
| » W: Paul Assenmacher (2-3) L: Dave Smith (3-4) | First | -- |
| Wednesday, August 30 |
| » Lost to Astros (71-62), 8-4 | Wrigley Field (38-30) | 75-58 | |
| » W: Mike Scott (18-7) L: Rick Sutcliffe (13-11) | First | -- |
| Friday, September 1 |
| » Lost to Braves (54-80), 5-1 | Atlanta-Fulton County Stadium (1-3) | 75-59 | Lost 2 |
| » W: Derek Lilliquist (8-8) L: Steve Wilson (5-3) S: Mike Stanton (2) | First | -- |
| Saturday, September 2 |
| » Defeated Braves (54-81), 10-3 | Atlanta-Fulton County Stadium (2-3) | 76-59 | |
| » W: Greg Maddux (16-10) L: Marty Clary (4-3) | First | -- |
| Sunday, September 3 |
| » Lost to Braves (55-81), 8-5 | Atlanta-Fulton County Stadium (2-4) | 76-60 | |
| » W: Pete Smith (5-13) L: Mike Bielecki (14-6) S: Mike Stanton (3) | First | -- |
| Monday, September 4 |
| » Defeated Mets (72-64), 7-3 | Shea Stadium (3-5) | 77-60 | |
| » W: Rick Sutcliffe (14-11) L: David Cone (12-7) S: Les Lancaster (6) | First | -- |
| Tuesday, September 5 |
| » Lost to Mets (73-64), 3-2 | Shea Stadium (3-6) | 77-61 | |
| » W: Sid Fernandez (11-3) L: Mitch Williams (4-3) | First | -- |
| Wednesday, September 6 |
| » Lost to Phillies (56-82), 9-1 | Veteran's Stadium (5-3) | 77-62 | Lost 2 |
| » W: Bruce Ruffin (5-8) L: Greg Maddux (16-11) | First | -- |
| Thursday, September 7 |
| » Defeated Phillies (56-83), 6-2 | Veteran's Stadium (6-3) | 78-62 | |
| » W: Mike Bielecki (15-6) L: Ken Howell (11-11) | First | -- |
| Friday, September 8 |
| » Lost to Cardinals (77-63), 11-8 | Wrigley Field (38-31) | 78-63 | |
| » W: Cris Carpenter (3-4) L: Mitch Williams (4-4) S: Dan Quisenberry (6) | First | -- |
| Saturday, September 9 |
| » Defeated Cardinals (77-64), 3-2 | Wrigley Field (39-31) | 79-63 | |
| » W: Paul Assenmacher (3-3) L: Ken Dayley (3-2) | First | -- |
| Sunday, September 10 |
| » Defeated Cardinals (77-65), 4-1 | Wrigley Field (40-31) | 80-63 | Won 2 |
| » W: Scott Sanderson (10-8) L: Ken Hill (7-12) S: Mitch Williams (32) | First | -- |
| Monday, September 11 |
| » Defeated Expos (76-68), 4-3 | Wrigley Field (41-31) | 81-63 | Won 3 |
| » W: Greg Maddux (17-11) L: Mark Langston (15-12) S: Mitch Williams (33) | First | -- |
| Tuesday, September 12 |
| » Defeated Expos (76-69), 2-0 | Wrigley Field (42-31) | 82-63 | Won 4 |
| » W: Mike Bielecki (16-6) L: Bryn Smith (10-9) | First | -- |
| Wednesday, September 13 |
| » Defeated Expos (76-70), 3-1 | Wrigley Field (43-31) | 83-63 | Won 5 |
| » W: Scott Sanderson (11-8) L: Kevin Gross (11-11) S: Les Lancaster (7) | First | -- |
| Friday, September 15 |
| » Defeated Pirates (66-80), 7-2 | Three Rivers Stadium (6-1) | 84-63 | Won 6 |
| » W: Rick Sutcliffe (15-11) L: Stan Belinda (0-1) | First | -- |
| Saturday, September 16 |
| » Lost to Pirates (67-80), 8-6 | Three Rivers Stadium (6-2) | 84-64 | |
| » W: John Smiley (12-7) L: Greg Maddux (17-12) | First | -- |
| Sunday, September 17 |
| » Lost to Pirates (68-80), 2-0 | Three Rivers Stadium (6-3) | 84-65 | Lost 2 |
| » W |