| Friday, February 24 |
| Former Cardinal Sparky Adams dies in Pottsville, PA at the age of 95. |
| Monday, April 3 |
| » Lost to Mets (1-0), 8-4 | Shea Stadium (0-1) | 0-1 | |
| » W: Dwight Gooden (1-0) L: Joe Magrane (0-1) S: Don Aase (1) | Third | 1 out |
| Wednesday, April 5 |
| » Defeated Mets (1-1), 3-1 | Shea Stadium (1-1) | 1-1 | |
| » W: Jose DeLeon (1-0) L: Bob Ojeda (0-1) S: Todd Worrell (1) | First | -- |
| Saturday, April 8 |
| » Lost to Phillies (3-1), 5-4 | Veteran's Stadium (0-1) | 1-2 | |
| » W: Jeff Parrett (1-0) L: John Costello (0-1) | Fourth | 2 out |
| Sunday, April 9 |
| » Defeated Phillies (3-2), 15-3 | Veteran's Stadium (1-1) | 2-2 | |
| » W: Joe Magrane (1-1) L: Bruce Ruffin (0-1) | Third | 1 out |
| Tuesday, April 11 |
| » Lost to Cubs (5-2), 5-4 | Wrigley Field (0-1) | 2-3 | |
| » W: Calvin Schiraldi (1-0) L: Jose DeLeon (1-1) S: Mitch Williams (3) | Third | 2 out |
| Wednesday, April 12 |
| » Lost to Cubs (6-2), 3-2 | Wrigley Field (0-2) | 2-4 | Lost 2 |
| » W: Paul Kilgus (1-1) L: Scott Terry (0-1) S: Mitch Williams (4) | Third | 3 out |
| Friday, April 14 |
| » Lost to Mets (3-5), 9-4 | Busch Stadium II (0-1) | 2-5 | Lost 3 |
| » W: David Cone (1-1) L: Joe Magrane (1-2) | Sixth | 4 out |
| Saturday, April 15 |
| » Defeated Mets (3-6), 3-2 | Busch Stadium II (1-1) | 3-5 | |
| » W: Dan Quisenberry (1-0) L: Don Aase (0-1) | Fifth | 3½ out |
| Sunday, April 16 |
| » Defeated Mets (3-7), 5-3 | Busch Stadium II (2-1) | 4-5 | Won 2 |
| » W: Jose DeLeon (2-1) L: Bob Ojeda (0-2) | Fourth | 3½ out |
| Monday, April 17 |
| » Defeated Pirates (4-8), 4-2 | Busch Stadium II (3-1) | 5-5 | Won 3 |
| » W: Scott Terry (1-1) L: Brian Fisher (0-1) S: Todd Worrell (2) | Fourth | 2½ out |
| Tuesday, April 18 |
| » Lost to Pirates (5-8), 4-3 | Busch Stadium II (3-2) | 5-6 | |
| » W: Morris Madden (1-0) L: Todd Worrell (0-1) S: Jeff Robinson (3) | Fourth | 2½ out |
| Wednesday, April 19 |
| » Lost to Pirates (6-8), 7-5 | Busch Stadium II (3-3) | 5-7 | Lost 2 |
| » W: Bob Walk (1-1) L: Don Heinkel (0-1) S: Jeff Robinson (4) | Fifth | 2½ out |
| Thursday, April 20 |
| » Defeated Expos (9-7), 5-2 | Busch Stadium II (4-3) | 6-7 | |
| » W: Ken Hill (1-0) L: Randy Johnson (0-3) S: Todd Worrell (3) | Third | 1½ out |
| Friday, April 21 |
| » Defeated Expos (9-8), 1-0 | Busch Stadium II (5-3) | 7-7 | Won 2 |
| » W: Jose DeLeon (3-1) L: Tim Burke (1-1) | Third | 1½ out |
| Saturday, April 22 |
| » Defeated Expos (9-9), 5-2 | Busch Stadium II (6-3) | 8-7 | Won 3 |
| » W: Scott Terry (2-1) L: Kevin Gross (2-2) | Second | ½ out |
| Sunday, April 23 |
| » Lost to Expos (10-9), 9-3 | Busch Stadium II (6-4) | 8-8 | |
| » W: Bryn Smith (2-0) L: Cris Carpenter (0-1) | Third | ½ out |
| Former Cardinal Howie Krist dies in Buffalo, NY at the age of 74. |
| Tuesday, April 25 |
| » Lost to Giants (11-8), 4-0 | Busch Stadium II (6-5) | 8-9 | Lost 2 |
| » W: Don Robinson (1-1) L: Ken Hill (1-1) S: Craig Lefferts (3) | Fourth | 1 out |
| Wednesday, April 26 |
| » Defeated Giants (11-9), 3-1 | Busch Stadium II (7-5) | 9-9 | |
| » W: Jose DeLeon (4-1) L: Kelly Downs (2-3) S: Ken Dayley (1) | Second | ½ out |
| Thursday, April 27 |
| » Defeated Giants (11-10), 10-1 | Busch Stadium II (8-5) | 10-9 | Won 2 |
| » W: Scott Terry (3-1) L: Scott Garrelts (2-1) | First | -- |
| Friday, April 28 |
| » Defeated Dodgers (11-11), 6-3 | Busch Stadium II (9-5) | 11-9 | Won 3 |
| » W: Don Heinkel (1-1) L: Tim Leary (2-2) | First | -- |
| Saturday, April 29 |
| » Defeated Dodgers (11-12), 1-0 | Busch Stadium II (10-5) | 12-9 | Won 4 |
| » W: Cris Carpenter (1-1) L: Ray Searage (0-2) | First | -- |
| Sunday, April 30 |
| » Defeated Dodgers (11-13), 4-3 | Busch Stadium II (11-5) | 13-9 | Won 5 |
| » W: Joe Magrane (2-2) L: Tim Belcher (2-2) S: Ken Dayley (2) | First | -- |
| Monday, May 1 |
| » Defeated Padres (14-13), 6-0 | San Diego/Jack Murphy Stadium (1-0) | 14-9 | Won 6 |
| » W: Jose DeLeon (5-1) L: Bruce Hurst (3-2) | First | -- |
| Tuesday, May 2 |
| » Lost to Padres (15-13), 7-1 | San Diego/Jack Murphy Stadium (1-1) | 14-10 | |
| » W: Ed Whitson (4-2) L: Scott Terry (3-2) | First | -- |
| Former Cardinal Virgil Stallcup dies in Greenville, SC at the age of 68. |
| Wednesday, May 3 |
| » Lost to Dodgers (14-13), 4-3 | Dodger Stadium (0-1) | 14-11 | Lost 2 |
| » W: Ray Searage (1-2) L: Ken Dayley (0-1) | First | -- |
| Thursday, May 4 |
| » Defeated Dodgers (14-14), 12-0 | Dodger Stadium (1-1) | 15-11 | |
| » W: Ken Hill (2-1) L: Fernando Valenzuela (0-3) | First | -- |
| Friday, May 5 |
| » Defeated Giants (14-15), 3-1 | Candlestick Park (1-0) | 16-11 | Won 2 |
| » W: Frank DiPino (1-0) L: Mike LaCoss (1-3) S: Todd Worrell (4) | First | -- |
| Saturday, May 6 |
| » Lost to Giants (15-15), 9-0 | Candlestick Park (1-1) | 16-12 | |
| » W: Rick Reuschel (5-2) L: Jose DeLeon (5-2) S: Mike LaCoss (3) | Second | ½ out |
| Sunday, May 7 |
| » Lost to Giants (16-15), 5-1 | Candlestick Park (1-2) | 16-13 | Lost 2 |
| » W: Don Robinson (2-3) L: Scott Terry (3-3) | Third | ½ out |
| Tuesday, May 9 |
| » Defeated Padres (17-17), 4-3 | Busch Stadium II (12-5) | 17-13 | |
| » W: Ken Dayley (1-1) L: Greg Harris (0-1) S: Todd Worrell (5) | First | -- |
| Wednesday, May 10 |
| » Defeated Padres (17-18), 3-1 | Busch Stadium II (13-5) | 18-13 | Won 2 |
| » W: Joe Magrane (3-2) L: Walt Terrell (3-4) S: Todd Worrell (6) | First | -- |
| Thursday, May 11 |
| » Defeated Padres (17-19), 6-5 | Busch Stadium II (14-5) | 19-13 | Won 3 |
| » W: Jose DeLeon (6-2) L: Eric Show (4-4) S: Dan Quisenberry (1) | First | -- |
| Friday, May 12 |
| » Lost to Reds (18-15), 5-0 | Busch Stadium II (14-6) | 19-14 | |
| » W: Rick Mahler (5-3) L: Ted Power (0-1) | First | -- |
| Saturday, May 13 |
| » Lost to Reds (19-15), 3-2 | Busch Stadium II (14-7) | 19-15 | Lost 2 |
| » W: Jose Rijo (4-0) L: Cris Carpenter (1-2) S: John Franco (12) | Second | ½ out |
| Sunday, May 14 |
| » Lost to Reds (20-15), 5-2 | Busch Stadium II (14-8) | 19-16 | Lost 3 |
| » W: Danny Jackson (2-6) L: Ken Hill (2-2) S: John Franco (13) | Second | 1½ out |
| Tuesday, May 16 |
| » Lost to Astros (18-19), 8-7 | Astrodome (0-1) | 19-17 | Lost 4 |
| » W: Dan Schatzeder (1-0) L: Cris Carpenter (1-3) | Second | 1½ out |
| Wednesday, May 17 |
| » Lost to Astros (19-19), 3-2 | Astrodome (0-2) | 19-18 | Lost 5 |
| » W: Larry Andersen (1-0) L: Joe Magrane (3-3) | Third | 1½ out |
| Former Cardinal Specs Toporcer dies in Huntington Station, NY at the age of 91. |
| Thursday, May 18 |
| » Defeated Astros (19-20), 4-3 | Astrodome (1-2) | 20-18 | |
| » W: Ken Dayley (2-1) L: Larry Andersen (1-1) | Second | 1½ out |
| Friday, May 19 |
| » Lost to Braves (19-22), 3-2 | Atlanta-Fulton County Stadium (0-1) | 20-19 | |
| » W: Joe Boever (2-1) L: Dan Quisenberry (1-1) | Third | 2½ out |
| Saturday, May 20 |
| » Defeated Braves (19-23), 1-0 | Atlanta-Fulton County Stadium (1-1) | 21-19 | |
| » W: Ken Dayley (3-1) L: Joe Boever (2-2) S: Dan Quisenberry (2) | Third | 1½ out |
| Sunday, May 21 |
| » Defeated Braves (19-24), 6-1 | Atlanta-Fulton County Stadium (2-1) | 22-19 | Won 2 |
| » W: Frank DiPino (2-0) L: Jose Alvarez (2-1) | Second | ½ out |
| Tuesday, May 23 |
| » Lost to Reds (24-18), 6-4 | Riverfront Stadium (0-1) | 22-20 | |
| » W: Danny Jackson (3-7) L: Matt Kinzer (0-1) S: John Franco (14) | Third | 1½ out |
| Wednesday, May 24 |
| » Lost to Reds (25-18), 5-1 | Riverfront Stadium (0-2) | 22-21 | Lost 2 |
| » W: Tom Browning (4-4) L: Ken Hill (2-3) | Third | 2½ out |
| Friday, May 26 |
| » Defeated Braves (19-28), 3-0 | Busch Stadium II (15-8) | 23-21 | |
| » W: Scott Terry (4-3) L: John Smoltz (6-3) S: Dan Quisenberry (3) | Third | 1½ out |
| Saturday, May 27 |
| » Lost to Braves (20-28), 4-1 | Busch Stadium II (15-9) | 23-22 | |
| » W: Jose Alvarez (3-1) L: Jose DeLeon (6-3) S: Joe Boever (6) | Third | 2½ out |
| Sunday, May 28 |
| » Tied Braves, 3-3 | Busch Stadium II (15-9) | 23-22 | |
| » Starters: Zane Smith vs Joe Magrane | Third | 3 out |
| Monday, May 29 |
| » Lost to Astros (25-24), 3-2 | Busch Stadium II (15-10) | 23-23 | Lost 2 |
| » W: Bob Knepper (3-6) L: Ken Hill (2-4) S: Dave Smith (9) | Fourth | 3 out |
| Tuesday, May 30 |
| » Lost to Astros (26-24), 8-4 | Busch Stadium II (15-11) | 23-24 | Lost 3 |
| » W: Danny Darwin (4-1) L: Scott Terry (4-4) | Fourth | 4 out |
| Wednesday, May 31 |
| » Lost to Astros (27-24), 4-3 | Busch Stadium II (15-12) | 23-25 | Lost 4 |
| » W: Dan Schatzeder (3-0) L: Cris Carpenter (1-4) S: Dave Smith (10) | Fourth | 4 out |
| Friday, June 2 |
| » Lost to Cubs (29-22), 5-2 | Busch Stadium II (15-13) | 23-26 | Lost 5 |
| » W: Rick Sutcliffe (7-3) L: Joe Magrane (3-4) S: Mitch Williams (14) | Fourth | 5 out |
| Saturday, June 3 |
| » Defeated Cubs (29-23), 6-5 | Busch Stadium II (16-13) | 24-26 | |
| » W: Dan Quisenberry (2-1) L: Calvin Schiraldi (1-3) | Fourth | 4 out |
| Sunday, June 4 |
| » Lost to Cubs (30-23), 11-3 | Busch Stadium II (16-14) | 24-27 | |
| » W: Scott Sanderson (6-3) L: Scott Terry (4-5) | Fourth | 5 out |
| Monday, June 5 |
| » Defeated Expos (30-26), 5-4 | Stade Olympique (1-0) | 25-27 | |
| » W: Jose DeLeon (7-3) L: Bryn Smith (5-2) S: John Costello (1) | Fourth | 5 out |
| Tuesday, June 6 |
| » Lost to Expos (31-26), 3-2 | Stade Olympique (1-1) | 25-28 | |
| » W: Pascual Perez (2-7) L: Joe Magrane (3-5) S: Tim Burke (13) | Fourth | 6 out |
| Wednesday, June 7 |
| » Defeated Expos (31-27), 5-2 | Stade Olympique (2-1) | 26-28 | |
| » W: Ken Hill (3-4) L: Mark Langston (5-6) S: Ken Dayley (3) | Fourth | 5 out |
| Thursday, June 8 |
| » Defeated Expos (31-28), 7-2 | Stade Olympique (3-1) | 27-28 | Won 2 |
| » W: Frank DiPino (3-0) L: Kevin Gross (6-4) | Fourth | 5 out |
| Former Cardinal Emil Verban dies in Quincy, IL at the age of 74. |
| Friday, June 9 |
| » Defeated Cubs (33-25), 1-0 | Wrigley Field (1-2) | 28-28 | Won 3 |
| » W: Jose DeLeon (8-3) L: Scott Sanderson (6-4) S: Todd Worrell (7) | Fourth | 4 out |
| Saturday, June 10 |
| » Defeated Cubs (33-26), 6-0 | Wrigley Field (2-2) | 29-28 | Won 4 |
| » W: Joe Magrane (4-5) L: Greg Maddux (5-6) | Third | 3 out |
| Former Cardinal Joe Stripp dies in Orlando, FL at the age of 87. |
| Sunday, June 11 |
| » Defeated Cubs (33-27), 10-7 | Wrigley Field (3-2) | 30-28 | Won 5 |
| » W: Cris Carpenter (2-4) L: Calvin Schiraldi (1-4) | Third | 2 out |
| Monday, June 12 |
| » Lost to Cubs (34-27), 10-3 | Wrigley Field (3-3) | 30-29 | |
| » W: Steve Wilson (3-0) L: Scott Terry (4-6) | Third | 3 out |
| Tuesday, June 13 |
| » Lost to Expos (35-28), 2-0 | Busch Stadium II (16-15) | 30-30 | Lost 2 |
| » W: Mark Langston (6-6) L: Jose DeLeon (8-4) | Third | 4 out |
| Wednesday, June 14 |
| » Defeated Expos (35-29), 10-0 | Busch Stadium II (17-15) | 31-30 | |
| » W: Joe Magrane (5-5) L: Kevin Gross (6-5) | Third | 3 out |
| Thursday, June 15 |
| » Defeated Expos (35-30), 4-3 | Busch Stadium II (18-15) | 32-30 | Won 2 |
| » W: Todd Worrell (1-1) L: Andy McGaffigan (1-3) | Third | 2 out |
| Friday, June 16 |
| » Defeated Pirates (25-37), 6-2 | Busch Stadium II (19-15) | 33-30 | Won 3 |
| » W: Scott Terry (5-6) L: Randy Kramer (1-3) S: Ken Dayley (4) | Third | 1½ out |
| Saturday, June 17 |
| » Lost to Pirates (26-37), 7-2 | Busch Stadium II (19-16) | 33-31 | |
| » W: Jeff Robinson (3-6) L: Jose DeLeon (8-5) S: Bob Kipper (2) | Fourth | 2 out |
| Sunday, June 18 |
| » Lost to Pirates (27-37), 12-4 | Busch Stadium II (19-17) | 33-32 | Lost 2 |
| » W: Morris Madden (2-1) L: Joe Magrane (5-6) S: Bill Landrum (4) | Fourth | 3 out |
| Tuesday, June 20 |
| » Defeated Phillies (23-42), 6-4 | Veteran's Stadium (2-1) | 34-32 | |
| » W: Ken Hill (4-4) L: Terry Mulholland (0-1) S: Ken Dayley (5) | Third | 2½ out |
| » Defeated Phillies (23-43), 5-3 | Veteran's Stadium (3-1) | 35-32 | Won 2 |
| » W: Frank DiPino (4-0) L: Steve Ontiveros (2-1) S: Todd Worrell (8) | Third | 2½ out |
| Thursday, June 22 |
| » Lost to Phillies (24-43), 11-2 | Veteran's Stadium (3-2) | 35-33 | |
| » W: Dennis Cook (2-0) L: Jose DeLeon (8-6) | Fourth | 4 out |
| Friday, June 23 |
| » Defeated Pirates (27-41), 3-2 | Three Rivers Stadium (1-0) | 36-33 | |
| » W: Joe Magrane (6-6) L: Morris Madden (2-2) S: Todd Worrell (9) | Fourth | 3 out |
| Saturday, June 24 |
| » Lost to Pirates (28-41), 5-2 | Three Rivers Stadium (1-1) | 36-34 | |
| » W: Bob Walk (6-4) L: Scott Terry (5-7) S: Bill Landrum (5) | Fourth | 3 out |
| Sunday, June 25 |
| » Lost to Pirates (29-41), 5-3 | Three Rivers Stadium (1-2) | 36-35 | Lost 2 |
| » W: John Smiley (7-2) L: Ted Power (0-2) S: Bill Landrum (6) | Fourth | 3 out |
| Monday, June 26 |
| » Lost to Phillies (25-46), 5-4 | Busch Stadium II (19-18) | 36-36 | Lost 3 |
| » W: Jeff Parrett (4-2) L: Todd Worrell (1-2) S: Roger McDowell (5) | Fourth | 3½ out |
| Tuesday, June 27 |
| » Lost to Phillies (26-46), 4-2 | Busch Stadium II (19-19) | 36-37 | Lost 4 |
| » W: Dennis Cook (3-0) L: Jose DeLeon (8-7) S: Roger McDowell (6) | Fourth | 4½ out |
| Wednesday, June 28 |
| » Defeated Phillies (26-47), 2-1 | Busch Stadium II (20-19) | 37-37 | |
| » W: Joe Magrane (7-6) L: Ken Howell (6-5) | Fourth | 4½ out |
| Friday, June 30 |
| » Defeated Padres (39-41), 4-3 | Busch Stadium II (21-19) | 38-37 | Won 2 |
| » W: Scott Terry (6-7) L: Walt Terrell (4-11) S: Todd Worrell (10) | Fourth | 4 out |
| Saturday, July 1 |
| » Defeated Padres (39-42), 9-3 | Busch Stadium II (22-19) | 39-37 | Won 3 |
| » W: Ted Power (1-2) L: Pat Clements (1-1) | Fourth | 3 out |
| Sunday, July 2 |
| » Lost to Padres (40-42), 5-2 | Busch Stadium II (22-20) | 39-38 | |
| » W: Bruce Hurst (7-5) L: Jose DeLeon (8-8) | Fourth | 4 out |
| Tuesday, July 4 |
| » Defeated Dodgers (39-43), 2-1 | Busch Stadium II (23-20) | 40-38 | |
| » W: Joe Magrane (8-6) L: Fernando Valenzuela (4-7) | Fourth | 3½ out |
| Wednesday, July 5 |
| » Defeated Dodgers (39-44), 3-2 | Busch Stadium II (24-20) | 41-38 | Won 2 |
| » W: John Costello (1-1) L: John Wetteland (2-1) S: Todd Worrell (11) | Fourth | 3½ out |
| Thursday, July 6 |
| » Defeated Dodgers (39-45), 14-2 | Busch Stadium II (25-20) | 42-38 | Won 3 |
| » W: Ken Hill (5-4) L: Tim Leary (6-6) S: Dan Quisenberry (4) | Third | 3 out |
| Friday, July 7 |
| » Defeated Giants (50-35), 6-4 | Busch Stadium II (26-20) | 43-38 | Won 4 |
| » W: Frank DiPino (5-0) L: Mike LaCoss (3-6) S: Ken Dayley (6) | Third | 3 out |
| » Major-league debuts: Mike Benjamin (Giants) |
| Saturday, July 8 |
| » Lost to Giants (51-35), 8-5 | Busch Stadium II (26-21) | 43-39 | |
| » W: Jeff Brantley (4-0) L: Ted Power (1-3) | Fourth | 3 out |
| Sunday, July 9 |
| » Defeated Giants (51-36), 6-4 | Busch Stadium II (27-21) | 44-39 | |
| » W: Joe Magrane (9-6) L: Trevor Wilson (1-2) S: Ken Dayley (7) | Fourth | 3 out |
| Thursday, July 13 |
| » Lost to Dodgers (41-47), 3-2 | Dodger Stadium (1-2) | 44-40 | |
| » W: Orel Hershiser (10-7) L: Ken Hill (5-5) S: Jay Howell (16) | Fourth | 4 out |
| Friday, July 14 |
| » Defeated Dodgers (41-48), 7-2 | Dodger Stadium (2-2) | 45-40 | |
| » W: Scott Terry (7-7) L: Mike Morgan (6-9) | Fourth | 4 out |
| Saturday, July 15 |
| » Defeated Dodgers (41-49), 2-0 | Dodger Stadium (3-2) | 46-40 | Won 2 |
| » W: Joe Magrane (10-6) L: Fernando Valenzuela (4-9) | Fourth | 3 out |
| Sunday, July 16 |
| » Lost to Dodgers (42-49), 3-2 | Dodger Stadium (3-3) | 46-41 | |
| » W: Tim Belcher (6-8) L: Jose DeLeon (8-9) S: Jay Howell (17) | Fourth | 4 out |
| Monday, July 17 |
| » Lost to Giants (55-37), 8-4 | Candlestick Park (1-3) | 46-42 | Lost 2 |
| » W: Randy McCament (1-0) L: Ted Power (1-4) S: Rich Gossage (4) | Third | 5 out |
| Tuesday, July 18 |
| » Lost to Giants (56-37), 7-3 | Candlestick Park (1-4) | 46-43 | Lost 3 |
| » W: Don Robinson (8-6) L: Ken Hill (5-6) | Fourth | 5 out |
| Former Cardinal Donnie Moore dies in Anaheim, CA at the age of 36. |
| Wednesday, July 19 |
| » Lost to Giants (57-37), 7-5 | Candlestick Park (1-5) | 46-44 | Lost 4 |
| » W: Jeff Brantley (6-0) L: Scott Terry (7-8) S: Craig Lefferts (16) | Fourth | 5 out |
| Thursday, July 20 |
| » Defeated Padres (47-49), 7-1 | San Diego/Jack Murphy Stadium (2-1) | 47-44 | |
| » W: Joe Magrane (11-6) L: Walt Terrell (5-13) | Fourth | 5 out |
| Friday, July 21 |
| » Defeated Padres (47-50), 5-0 | San Diego/Jack Murphy Stadium (3-1) | 48-44 | Won 2 |
| » W: Jose DeLeon (9-9) L: Dennis Rasmussen (4-7) | Fourth | 5 out |
| Saturday, July 22 |
| » Defeated Padres (47-51), 5-2 | San Diego/Jack Murphy Stadium (4-1) | 49-44 | Won 3 |
| » W: Ted Power (2-4) L: Greg Harris (3-5) | Fourth | 5 out |
| Sunday, July 23 |
| » Defeated Padres (47-52), 3-2 | San Diego/Jack Murphy Stadium (5-1) | 50-44 | Won 4 |
| » W: Ken Hill (6-6) L: Bruce Hurst (8-8) S: Todd Worrell (12) | Fourth | 5 out |
| Monday, July 24 |
| » Lost to Cubs (54-44), 3-2 | Busch Stadium II (27-22) | 50-45 | |
| » W: Mike Bielecki (10-5) L: Scott Terry (7-9) S: Mitch Williams (24) | Fourth | 6 out |
| Tuesday, July 25 |
| » Lost to Cubs (55-44), 4-2 | Busch Stadium II (27-23) | 50-46 | Lost 2 |
| » W: Paul Kilgus (6-9) L: Joe Magrane (11-7) S: Mitch Williams (25) | Fourth | 7 out |
| Wednesday, July 26 |
| » Defeated Cubs (55-45), 2-0 | Busch Stadium II (28-23) | 51-46 | |
| » W: Jose DeLeon (10-9) L: Rick Sutcliffe (10-9) S: Todd Worrell (13) | Fourth | 6 out |
| Friday, July 28 |
| » Defeated Expos (59-43), 2-0 | Stade Olympique (4-1) | 52-46 | Won 2 |
| » W: Ted Power (3-4) L: Pascual Perez (5-10) S: Todd Worrell (14) | Third | 5 out |
| Saturday, July 29 |
| » Lost to Expos (60-43), 2-0 | Stade Olympique (4-2) | 52-47 | |
| » W: Dennis Martinez (12-1) L: Ken Hill (6-7) | Fourth | 6 out |
| Sunday, July 30 |
| » Defeated Expos (60-44), 8-3 | Stade Olympique (5-2) | 53-47 | |
| » W: Joe Magrane (12-7) L: Bryn Smith (9-4) | Third | 5 out |
| Monday, July 31 |
| » Defeated Mets (53-50), 3-2 | Busch Stadium II (29-23) | 54-47 | Won 2 |
| » W: Jose DeLeon (11-9) L: Ron Darling (8-9) S: Todd Worrell (15) | Third | 5 out |
| Tuesday, August 1 |
| » Lost to Mets (54-50), 11-0 | Busch Stadium II (29-24) | 54-48 | |
| » W: Sid Fernandez (9-3) L: Scott Terry (7-10) | Third | 6 out |
| Wednesday, August 2 |
| » Lost to Mets (55-50), 4-3 | Busch Stadium II (29-25) | 54-49 | Lost 2 |
| » W: Frank Viola (9-12) L: Todd Worrell (1-3) S: Randy Myers (16) | Fourth | 7 out |
| Thursday, August 3 |
| » Defeated Mets (55-51), 6-5 | Busch Stadium II (30-25) | 55-49 | |
| » W: Dan Quisenberry (3-1) L: Jeff Musselman (0-2) S: Ken Dayley (8) | Third | 6 out |
| Friday, August 4 |
| » Defeated Phillies (43-65), 6-3 | Busch Stadium II (31-25) | 56-49 | Won 2 |
| » W: Joe Magrane (13-7) L: Dennis Cook (5-4) S: Todd Worrell (16) | Third | 5 out |
| Saturday, August 5 |
| » Lost to Phillies (44-65), 7-3 | Busch Stadium II (31-26) | 56-50 | |
| » W: Terry Mulholland (2-5) L: Jose DeLeon (11-10) S: Jeff Parrett (5) | Third | 5 out |
| Former Cardinal Max Macon dies in Jupiter, FL at the age of 74. |
| Sunday, August 6 |
| » Defeated Phillies (44-66), 5-4 | Busch Stadium II (32-26) | 57-50 | |
| » W: Todd Worrell (2-3) L: Jeff Parrett (8-4) | Second | 4 out |
| Monday, August 7 |
| » Defeated Pirates (47-64), 4-0 | Three Rivers Stadium (2-2) | 58-50 | Won 2 |
| » W: Ted Power (4-4) L: Rick Reed (0-3) | Third | 4 out |
| Tuesday, August 8 |
| » Lost to Pirates (48-64), 7-3 | Three Rivers Stadium (2-3) | 58-51 | |
| » W: Bob Walk (9-7) L: Ken Hill (6-8) | Fourth | 5 out |
| Wednesday, August 9 |
| » Defeated Pirates (48-65), 5-2 | Three Rivers Stadium (3-3) | 59-51 | |
| » W: Joe Magrane (14-7) L: Doug Drabek (9-9) | Fourth | 5 out |
| Thursday, August 10 |
| » Lost to Mets (61-52), 5-1 | Shea Stadium (1-2) | 59-52 | |
| » W: Ron Darling (10-9) L: Jose DeLeon (11-11) | Fourth | 5½ out |
| » Lost to Mets (62-52), 6-4 | Shea Stadium (1-3) | 59-53 | Lost 2 |
| » W: Jeff Musselman (2-3) L: John Costello (1-2) S: Randy Myers (17) | Fourth | 5½ out |
| Friday, August 11 |
| » Defeated Mets (62-53), 3-0 | Shea Stadium (2-3) | 60-53 | |
| » W: Scott Terry (8-10) L: Frank Viola (9-13) S: Ken Dayley (9) | Fourth | 5½ out |
| Saturday, August 12 |
| » Lost to Mets (63-53), 3-1 | Shea Stadium (2-4) | 60-54 | |
| » W: David Cone (10-5) L: Ted Power (4-5) S: Randy Myers (18) | Fourth | 6½ out |
| Sunday, August 13 |
| » Lost to Mets (64-53), 3-2 | Shea Stadium (2-5) | 60-55 | Lost 2 |
| » W: Bob Ojeda (9-9) L: Ken Hill (6-9) S: Randy Myers (19) | Fourth | 6½ out |
| Monday, August 14 |
| » Defeated Braves (48-70), 7-4 | Busch Stadium II (33-26) | 61-55 | |
| » W: Joe Magrane (15-7) L: John Smoltz (11-11) S: Todd Worrell (17) | Fourth | 5½ out |
| » Defeated Braves (48-71), 5-2 | Busch Stadium II (34-26) | 62-55 | Won 2 |
| » W: John Costello (2-2) L: Pete Smith (3-12) S: Ken Dayley (10) | Fourth | 5½ out |
| Tuesday, August 15 |
| » Defeated Braves (48-72), 9-1 | Busch Stadium II (35-26) | 63-55 | Won 3 |
| » W: Jose DeLeon (12-11) L: Derek Lilliquist (7-7) | Fourth | 5½ out |
| Wednesday, August 16 |
| » Defeated Braves (48-73), 3-2 | Busch Stadium II (36-26) | 64-55 | Won 4 |
| » W: Frank DiPino (6-0) L: Jim Acker (0-6) S: Todd Worrell (18) | Fourth | 5½ out |
| Thursday, August 17 |
| Former Cardinal Fred Frankhouse dies in Port Royal, PA at the age of 86. |
| Friday, August 18 |
| » Lost to Reds (57-64), 6-2 | Riverfront Stadium (0-3) | 64-56 | |
| » W: Tom Browning (12-10) L: Ken Hill (6-10) | Fourth | 6½ out |
| » Lost to Reds (58-64), 8-3 | Riverfront Stadium (0-4) | 64-57 | Lost 2 |
| » W: Rob Dibble (7-3) L: Todd Worrell (2-4) | Fourth | 6½ out |
| » Major-league debuts: Todd Zeile (Cardinals) |
| Saturday, August 19 |
| » Defeated Reds (58-65), 5-1 | Riverfront Stadium (1-4) | 65-57 | |
| » W: Joe Magrane (16-7) L: Rick Mahler (9-12) | Fourth | 5½ out |
| Sunday, August 20 |
| » Defeated Reds (58-66), 8-1 | Riverfront Stadium (2-4) | 66-57 | Won 2 |
| » W: Jose DeLeon (13-11) L: Tim Leary (8-11) | Fourth | 4½ out |
| Monday, August 21 |
| Former Cardinal Ted Wilks dies in Houston, TX at the age of 74. |
| Tuesday, August 22 |
| » Defeated Braves (50-75), 10-5 | Atlanta-Fulton County Stadium (3-1) | 67-57 | Won 3 |
| » W: Ted Power (5-5) L: Derek Lilliquist (7-8) | Fourth | 3 out |
| Wednesday, August 23 |
| » Lost to Braves (51-75), 3-0 | Atlanta-Fulton County Stadium (3-2) | 67-58 | |
| » W: Marty Clary (4-2) L: Ricky Horton (0-1) | Fourth | 3 out |
| Thursday, August 24 |
| » Defeated Braves (51-76), 4-1 | Atlanta-Fulton County Stadium (4-2) | 68-58 | |
| » W: Joe Magrane (17-7) L: Tom Glavine (12-7) | Fourth | 2½ out |
| » Major-league debuts: Mike Stanton (Braves) |
| Friday, August 25 |
| » Defeated Astros (69-59), 7-4 | Astrodome (2-2) | 69-58 | Won 2 |
| » W: Jose DeLeon (14-11) L: Mike Scott (17-7) | Third | 2½ out |
| Saturday, August 26 |
| » Defeated Astros (69-60), 5-3 | Astrodome (3-2) | 70-58 | Won 3 |
| » W: Ken Hill (7-10) L: Rick Rhoden (1-5) S: Todd Worrell (19) | Second | 1½ out |
| Sunday, August 27 |
| » Lost to Astros (70-60), 6-3 | Astrodome (3-3) | 70-59 | |
| » W: Bob Forsch (4-4) L: Ted Power (5-6) S: Dave Smith (23) | Third | 2½ out |
| Monday, August 28 |
| » Defeated Reds (63-68), 3-2 | Busch Stadium II (37-26) | 71-59 | |
| » W: John Costello (3-2) L: Rob Dibble (7-4) S: Todd Worrell (20) | Second | 2½ out |
| Tuesday, August 29 |
| » Defeated Reds (63-69), 4-2 | Busch Stadium II (38-26) | 72-59 | Won 2 |
| » W: Joe Magrane (18-7) L: Tim Leary (8-12) | Second | 2½ out |
| Wednesday, August 30 |
| » Lost to Reds (64-69), 2-0 | Busch Stadium II (38-27) | 72-60 | |
| » W: Rob Dibble (8-4) L: Todd Worrell (2-5) S: John Franco (29) | Second | 2½ out |
| Friday, September 1 |
| » Lost to Astros (72-62), 6-3 | Busch Stadium II (38-28) | 72-61 | Lost 2 |
| » W: Jim Deshaies (12-7) L: John Costello (3-3) | Second | 2½ out |
| Saturday, September 2 |
| » Defeated Astros (72-63), 13-5 | Busch Stadium II (39-28) | 73-61 | |
| » W: Ted Power (6-6) L: Bob Forsch (4-5) | Second | 2½ out |
| Sunday, September 3 |
| » Defeated Astros (72-64), 4-3 | Busch Stadium II (40-28) | 74-61 | Won 2 |
| » W: Todd Worrell (3-5) L: Danny Darwin (11-4) | Second | 1½ out |
| Monday, September 4 |
| » Defeated Expos (73-64), 4-1 | Busch Stadium II (41-28) | 75-61 | Won 3 |
| » W: Jose DeLeon (15-11) L: Dennis Martinez (15-5) S: Dan Quisenberry (5) | Second | 1½ out |
| Tuesday, September 5 |
| » Lost to Expos (74-64), 6-2 | Busch Stadium II (41-29) | 75-62 | |
| » W: Pascual Perez (8-12) L: Ken Hill (7-11) | Second | 1½ out |
| Wednesday, September 6 |
| » Defeated Mets (73-65), 3-2 | Shea Stadium (3-5) | 76-62 | |
| » W: Frank DiPino (7-0) L: Ron Darling (12-12) S: Ken Dayley (11) | Second | ½ out |
| Thursday, September 7 |
| » Lost to Mets (74-65), 13-1 | Shea Stadium (3-6) | 76-63 | |
| » W: Frank Viola (11-16) L: Ted Power (6-7) | Second | 1½ out |
| » Major-league debuts: Julio Machado (Mets) |
| Friday, September 8 |
| » Defeated Cubs (78-63), 11-8 | Wrigley Field (4-3) | 77-63 | |
| » W: Cris Carpenter (3-4) L: Mitch Williams (4-4) S: Dan Quisenberry (6) | Second | ½ out |
| Saturday, September 9 |
| » Lost to Cubs (79-63), 3-2 | Wrigley Field (4-4) | 77-64 | |
| » W: Paul Assenmacher (3-3) L: Ken Dayley (3-2) | Second | 1½ out |
| Sunday, September 10 |
| » Lost to Cubs (80-63), 4-1 | Wrigley Field (4-5) | 77-65 | Lost 2 |
| » W: Scott Sanderson (10-8) L: Ken Hill (7-12) S: Mitch Williams (32) | Second | 2½ out |
| Monday, September 11 |
| » Lost to Pirates (64-79), 3-1 | Busch Stadium II (41-30) | 77-66 | Lost 3 |
| » W: Neal Heaton (4-7) L: Ricky Horton (0-2) S: Doug Bair (1) | Second | 3½ out |
| Tuesday, September 12 |
| » Lost to Pirates (65-79), 5-2 | Busch Stadium II (41-31) | 77-67 | Lost 4 |
| » W: Bob Walk (13-10) L: Joe Magrane (18-8) | Second | 4½ out |
| Wednesday, September 13 |
| » Tied Pirates, 0-0 | Busch Stadium II (41-31) | 77-67 | |
| » Starters: Doug Drabek vs Jose DeLeon | Second | 5 out |
| Thursday, September 14 |
| » Lost to Pirates (66-79), 4-3 | Busch Stadium II (41-32) | 77-68 | Lost 5 |
| » W: Bob Patterson (2-2) L: Ken Dayley (3-3) S: Bob Kipper (4) | Second | 5½ out |
| Friday, September 15 |
| » Lost to Phillies (60-86), 2-0 | Veteran's Stadium (3-3) | 77-69 | Lost 6 |
| » W: Pat Combs (2-0) L: Ken Hill (7-13) | Third | 6 out |
| » Defeated Phillies (60-87), 7-6 | Veteran's Stadium (4-3) | 78-69 | |
| » W: John Costello (4-3) L: Roger McDowell (4-7) | Third | 6 out |
| Saturday, September 16< |