| Monday, April 3 |
| » Defeated Royals (0-1), 4-3 | Royals Stadium (1-0) | 1-0 | |
| » W: Jimmy Key (1-0) L: Mark Gubicza (0-1) S: Tom Henke (1) | First | -- |
| Wednesday, April 5 |
| » Lost to Royals (1-1), 2-1 | Royals Stadium (1-1) | 1-1 | |
| » W: Tom Gordon (1-0) L: Todd Stottlemyre (0-1) | Second | ½ out |
| Thursday, April 6 |
| » Lost to Royals (2-1), 3-2 | Royals Stadium (1-2) | 1-2 | Lost 2 |
| » W: Jeff Montgomery (1-0) L: Duane Ward (0-1) S: Steve Farr (1) | Third | 1½ out |
| Friday, April 7 |
| » Defeated Rangers (2-1), 10-9 | Arlington Stadium (1-0) | 2-2 | |
| » W: Tony Castillo (1-0) L: Cecilio Guante (1-1) S: Tom Henke (2) | Second | ½ out |
| Saturday, April 8 |
| » Lost to Rangers (3-1), 5-4 | Arlington Stadium (1-1) | 2-3 | |
| » W: Jamie Moyer (1-0) L: Jimmy Key (1-1) S: Jeff Russell (2) | Third | 1½ out |
| Sunday, April 9 |
| » Lost to Rangers (4-1), 3-2 | Arlington Stadium (1-2) | 2-4 | Lost 2 |
| » W: Kenny Rogers (1-0) L: Tom Henke (0-1) | Fourth | 2½ out |
| Monday, April 10 |
| » Defeated Yankees (1-6), 8-0 | Yankee Stadium (1-0) | 3-4 | |
| » W: Dave Stieb (1-0) L: Andy Hawkins (0-2) | Third | 1½ out |
| Tuesday, April 11 |
| » Defeated Yankees (1-7), 11-6 | Yankee Stadium (2-0) | 4-4 | Won 2 |
| » W: Tom Henke (1-1) L: Dave Righetti (0-1) | Second | 1 out |
| Wednesday, April 12 |
| » Lost to Yankees (2-7), 5-3 | Yankee Stadium (2-1) | 4-5 | |
| » W: John Candelaria (1-1) L: Tony Castillo (1-1) S: Lee Guetterman (1) | Third | 2 out |
| Friday, April 14 |
| » Defeated Royals (6-4), 3-0 | Exhibition Stadium (1-0) | 5-5 | |
| » W: Jimmy Key (2-1) L: Charlie Leibrandt (0-1) | Second | ½ out |
| Saturday, April 15 |
| » Lost to Royals (7-4), 10-5 | Exhibition Stadium (1-1) | 5-6 | |
| » W: Luis Aquino (2-0) L: Duane Ward (0-2) | Second | ½ out |
| Sunday, April 16 |
| » Defeated Royals (7-5), 15-8 | Exhibition Stadium (2-1) | 6-6 | |
| » W: David Wells (1-0) L: Bret Saberhagen (1-1) S: Tony Castillo (1) | Second | 1 out |
| Monday, April 17 |
| » Lost to Yankees (4-8), 7-2 | Exhibition Stadium (2-2) | 6-7 | |
| » W: Andy Hawkins (1-2) L: Mike Flanagan (0-1) | Second | 1 out |
| Tuesday, April 18 |
| » Lost to Yankees (5-8), 2-0 | Exhibition Stadium (2-3) | 6-8 | Lost 2 |
| » W: Dave LaPoint (1-1) L: Jeff Musselman (0-1) S: Dave Righetti (1) | Third | 1 out |
| Wednesday, April 19 |
| » Lost to Yankees (6-8), 4-2 | Exhibition Stadium (2-4) | 6-9 | Lost 3 |
| » W: John Candelaria (2-1) L: Jimmy Key (2-2) S: Lee Guetterman (3) | Fifth | 1½ out |
| Friday, April 21 |
| » Defeated Rangers (12-3), 6-3 | Exhibition Stadium (3-4) | 7-9 | |
| » W: Dave Stieb (2-0) L: Kevin Brown (1-1) S: Duane Ward (1) | Third | 1 out |
| Saturday, April 22 |
| » Defeated Rangers (12-4), 4-2 | Exhibition Stadium (4-4) | 8-9 | Won 2 |
| » W: Duane Ward (1-2) L: Charlie Hough (2-1) | Second | ½ out |
| Sunday, April 23 |
| » Lost to Rangers (13-4), 4-1 | Exhibition Stadium (4-5) | 8-10 | |
| » W: Nolan Ryan (2-1) L: Todd Stottlemyre (0-2) | Second | 1½ out |
| Monday, April 24 |
| » Lost to Athletics (14-6), 5-4 | Oakland-Alameda County Stadium (0-1) | 8-11 | Lost 2 |
| » W: Gene Nelson (1-0) L: Tom Henke (1-2) | Fifth | 1½ out |
| Tuesday, April 25 |
| » Lost to Athletics (15-6), 3-1 | Oakland-Alameda County Stadium (0-2) | 8-12 | Lost 3 |
| » W: Storm Davis (2-1) L: John Cerutti (0-1) S: Dennis Eckersley (7) | Sixth | 2½ out |
| Wednesday, April 26 |
| » Lost to Mariners (9-13), 7-6 | Kingdome (0-1) | 8-13 | Lost 4 |
| » W: Steve Trout (2-1) L: David Wells (1-1) S: Mike Jackson (1) | Sixth | 3½ out |
| Thursday, April 27 |
| » Defeated Mariners (9-14), 6-1 | Kingdome (1-1) | 9-13 | |
| » W: Mike Flanagan (1-1) L: Mike Dunne (1-2) | Fifth | 2½ out |
| Friday, April 28 |
| » Lost to Angels (13-10), 9-0 | Anaheim Stadium (0-1) | 9-14 | |
| » W: Kirk McCaskill (4-1) L: Todd Stottlemyre (0-3) | Sixth | 2½ out |
| Saturday, April 29 |
| » Lost to Angels (14-10), 4-3 | Anaheim Stadium (0-2) | 9-15 | Lost 2 |
| » W: Greg Minton (1-0) L: Duane Ward (1-3) | Fourth | 2½ out |
| Sunday, April 30 |
| » Lost to Angels (15-10), 1-0 | Anaheim Stadium (0-3) | 9-16 | Lost 3 |
| » W: Bob McClure (1-0) L: Tom Henke (1-3) | Fifth | 3½ out |
| Tuesday, May 2 |
| » Lost to Athletics (19-8), 8-5 | Exhibition Stadium (4-6) | 9-17 | Lost 4 |
| » W: Rick Honeycutt (1-0) L: Duane Ward (1-4) S: Eric Plunk (1) | Sixth | 4½ out |
| Wednesday, May 3 |
| » Defeated Athletics (19-9), 2-0 | Exhibition Stadium (5-6) | 10-17 | |
| » W: Mike Flanagan (2-1) L: Mike Moore (3-2) | Sixth | 4 out |
| » Major-league debuts: Junior Felix (Blue Jays) |
| Thursday, May 4 |
| » Lost to Angels (17-11), 3-2 | Exhibition Stadium (5-7) | 10-18 | |
| » W: Bryan Harvey (1-0) L: Duane Ward (1-5) S: Greg Minton (3) | Fourth | 4 out |
| Friday, May 5 |
| » Lost to Angels (18-11), 5-3 | Exhibition Stadium (5-8) | 10-19 | Lost 2 |
| » W: Jim Abbott (2-2) L: John Cerutti (0-2) S: Bryan Harvey (5) | Sixth | 5 out |
| Saturday, May 6 |
| » Lost to Angels (19-11), 5-4 | Exhibition Stadium (5-9) | 10-20 | Lost 3 |
| » W: Bob McClure (2-0) L: Duane Ward (1-6) | Sixth | 6 out |
| Monday, May 8 |
| » Defeated Mariners (17-16), 10-1 | Exhibition Stadium (6-9) | 11-20 | |
| » W: Dave Stieb (3-0) L: Mike Dunne (2-3) | Sixth | 5½ out |
| Tuesday, May 9 |
| » Lost to Mariners (18-16), 4-3 | Exhibition Stadium (6-10) | 11-21 | |
| » W: Erik Hanson (4-2) L: Mike Flanagan (2-2) S: Mike Schooler (7) | Sixth | 5½ out |
| Wednesday, May 10 |
| » Defeated Mariners (18-17), 3-2 | Exhibition Stadium (7-10) | 12-21 | |
| » W: Jimmy Key (3-2) L: Mark Langston (4-4) | Sixth | 5 out |
| Friday, May 12 |
| » Lost to Twins (14-18), 6-5 | Hubert H. Humphrey Metrodome (0-1) | 12-22 | |
| » W: Juan Berenguer (1-0) L: David Wells (1-2) S: Jeff Reardon (6) | Fifth | 6 out |
| Saturday, May 13 |
| » Lost to Twins (15-18), 10-8 | Hubert H. Humphrey Metrodome (0-2) | 12-23 | Lost 2 |
| » W: Shane Rawley (3-4) L: Dave Stieb (3-1) S: Jeff Reardon (7) | Sixth | 6 out |
| Sunday, May 14 |
| » Lost to Twins (16-18), 13-1 | Hubert H. Humphrey Metrodome (0-3) | 12-24 | Lost 3 |
| » W: Frank Viola (2-5) L: Mike Flanagan (2-3) | Fourth | 6 out |
| Monday, May 15 |
| » Defeated Indians (17-18), 5-3 | Exhibition Stadium (8-10) | 13-24 | |
| » Manager: Cito Gaston |
| » W: Jimmy Key (4-2) L: John Farrell (2-3) | Sixth | 5½ out |
| Tuesday, May 16 |
| » Defeated Indians (17-19), 7-6 | Exhibition Stadium (9-10) | 14-24 | Won 2 |
| » W: Tom Henke (2-3) L: Keith Atherton (0-2) S: Duane Ward (2) | Sixth | 4½ out |
| Wednesday, May 17 |
| » Lost to Indians (18-19), 6-3 | Exhibition Stadium (9-11) | 14-25 | |
| » W: Bud Black (2-5) L: Dave Stieb (3-2) S: Doug Jones (7) | Sixth | 5 out |
| Friday, May 19 |
| » Defeated White Sox (17-23), 9-3 | Comiskey Park I (1-0) | 15-25 | |
| » W: Mike Flanagan (3-3) L: Eric King (4-4) | Sixth | 5 out |
| Saturday, May 20 |
| » Defeated White Sox (17-24), 11-1 | Comiskey Park I (2-0) | 16-25 | Won 2 |
| » W: Jimmy Key (5-2) L: Shawn Hillegas (1-5) | Sixth | 4 out |
| Sunday, May 21 |
| » Defeated White Sox (17-25), 9-3 | Comiskey Park I (3-0) | 17-25 | Won 3 |
| » W: John Cerutti (1-2) L: Melido Perez (2-5) S: Duane Ward (3) | Sixth | 3½ out |
| Monday, May 22 |
| » Lost to Twins (20-22), 6-2 | Exhibition Stadium (9-12) | 17-26 | |
| » W: Allan Anderson (5-2) L: Dave Stieb (3-3) | Fifth | 4½ out |
| Tuesday, May 23 |
| » Defeated Twins (20-23), 2-1 | Exhibition Stadium (10-12) | 18-26 | |
| » W: David Wells (2-2) L: Juan Berenguer (2-2) | Fifth | 3½ out |
| » Major-league debuts: Alex Sanchez (Blue Jays) |
| Wednesday, May 24 |
| » Lost to Twins (21-23), 10-4 | Exhibition Stadium (10-13) | 18-27 | |
| » W: Frank Viola (3-6) L: Mike Flanagan (3-4) | Fifth | 4½ out |
| Friday, May 26 |
| » Defeated White Sox (17-29), 11-3 | Exhibition Stadium (11-13) | 19-27 | |
| » W: Jimmy Key (6-2) L: Shawn Hillegas (1-6) | Sixth | 4½ out |
| Saturday, May 27 |
| » Lost to White Sox (18-29), 5-3 | Exhibition Stadium (11-14) | 19-28 | |
| » W: Melido Perez (3-5) L: John Cerutti (1-3) S: Bobby Thigpen (7) | Seventh | 5½ out |
| Sunday, May 28 |
| » Defeated White Sox (18-30), 7-5 | Exhibition Stadium (12-14) | 20-28 | |
| » W: Tom Henke (3-3) L: Bobby Thigpen (0-1) | Fifth | 4½ out |
| Monday, May 29 |
| » Lost to Indians (23-26), 5-3 | Cleveland Stadium (0-1) | 20-29 | |
| » W: Tom Candiotti (6-2) L: Mike Flanagan (3-5) S: Doug Jones (10) | Seventh | 5½ out |
| Tuesday, May 30 |
| » Lost to Indians (24-26), 6-2 | Cleveland Stadium (0-2) | 20-30 | Lost 2 |
| » W: John Farrell (3-5) L: Alex Sanchez (0-1) | Sixth | 6½ out |
| Wednesday, May 31 |
| » Lost to Indians (25-26), 7-4 | Cleveland Stadium (0-3) | 20-31 | Lost 3 |
| » W: Bud Black (4-6) L: Jimmy Key (6-3) S: Doug Jones (11) | Sixth | 7½ out |
| Friday, June 2 |
| » Defeated Red Sox (24-25), 7-2 | Fenway Park (1-0) | 21-31 | |
| » W: John Cerutti (2-3) L: John Dopson (5-4) S: Duane Ward (4) | Seventh | 8 out |
| Saturday, June 3 |
| » Defeated Red Sox (24-26), 10-2 | Fenway Park (2-0) | 22-31 | Won 2 |
| » W: Dave Stieb (4-3) L: Mike Boddicker (3-5) | Fifth | 8 out |
| Sunday, June 4 |
| » Defeated Red Sox (24-27), 13-11 | Fenway Park (3-0) | 23-31 | Won 3 |
| » W: Duane Ward (2-6) L: Dennis Lamp (0-1) | Sixth | 8 out |
| » Major-league debuts: Xavier Hernandez (Blue Jays) |
| Monday, June 5 |
| » Lost to Brewers (25-30), 5-3 | Skydome (0-1) | 23-32 | |
| » W: Don August (5-6) L: Jimmy Key (6-4) S: Dan Plesac (13) | Fifth | 9 out |
| Tuesday, June 6 |
| » Lost to Brewers (26-30), 6-4 | Skydome (0-2) | 23-33 | Lost 2 |
| » W: Jay Aldrich (1-0) L: Duane Ward (2-7) S: Chuck Crim (3) | Fifth | 9 out |
| Wednesday, June 7 |
| » Defeated Brewers (26-31), 4-2 | Skydome (1-2) | 24-33 | |
| » W: John Cerutti (3-3) L: Chris Bosio (6-4) | Sixth | 8½ out |
| Friday, June 9 |
| » Defeated Tigers (23-35), 2-0 | Skydome (2-2) | 25-33 | Won 2 |
| » W: Dave Stieb (5-3) L: Frank Tanana (5-6) S: David Wells (1) | Sixth | 8 out |
| Saturday, June 10 |
| » Lost to Tigers (24-35), 11-8 | Skydome (2-3) | 25-34 | |
| » W: Frank Williams (3-2) L: Jimmy Key (6-5) | Sixth | 8 out |
| Sunday, June 11 |
| » Defeated Tigers (24-36), 4-0 | Skydome (3-3) | 26-34 | |
| » W: Mike Flanagan (4-5) L: Mike Schwabe (1-1) S: Duane Ward (5) | Fifth | 7 out |
| Monday, June 12 |
| » Defeated Tigers (24-37), 5-4 | Skydome (4-3) | 27-34 | Won 2 |
| » W: Tom Henke (4-3) L: Paul Gibson (2-4) | Fifth | 6½ out |
| Tuesday, June 13 |
| » Defeated Brewers (29-33), 4-3 | County Stadium (1-0) | 28-34 | Won 3 |
| » W: Duane Ward (3-7) L: Dan Plesac (2-3) | Sixth | 6½ out |
| Wednesday, June 14 |
| » Defeated Brewers (29-34), 6-1 | County Stadium (2-0) | 29-34 | Won 4 |
| » W: Dave Stieb (6-3) L: Bill Krueger (2-1) | Fifth | 5½ out |
| Thursday, June 15 |
| » Lost to Brewers (30-34), 6-4 | County Stadium (2-1) | 29-35 | |
| » W: Tony Fossas (1-0) L: Jimmy Key (6-6) S: Dan Plesac (15) | Fifth | 6½ out |
| Friday, June 16 |
| » Defeated Mariners (31-36), 4-3 | Skydome (5-3) | 30-35 | |
| » W: Tom Henke (5-3) L: Mike Schooler (1-1) | Fifth | 6 out |
| Saturday, June 17 |
| » Defeated Mariners (31-37), 3-2 | Skydome (6-3) | 31-35 | Won 2 |
| » W: Duane Ward (4-7) L: Mike Jackson (2-1) | Fifth | 6 out |
| Sunday, June 18 |
| » Lost to Mariners (32-37), 8-2 | Skydome (6-4) | 31-36 | |
| » W: Scott Bankhead (4-4) L: Frank Wills (0-1) | Fourth | 7 out |
| Monday, June 19 |
| » Defeated Angels (39-27), 8-1 | Anaheim Stadium (1-3) | 32-36 | |
| » W: Dave Stieb (7-3) L: Chuck Finley (7-6) | Fourth | 7 out |
| Tuesday, June 20 |
| » Defeated Angels (39-28), 6-2 | Anaheim Stadium (2-3) | 33-36 | Won 2 |
| » W: Jimmy Key (7-6) L: Kirk McCaskill (7-4) | Fourth | 7 out |
| Wednesday, June 21 |
| » Defeated Angels (39-29), 6-1 | Anaheim Stadium (3-3) | 34-36 | Won 3 |
| » W: Tom Henke (6-3) L: Greg Minton (1-2) | Second | 7 out |
| Thursday, June 22 |
| » Defeated Athletics (44-28), 4-2 | Oakland-Alameda County Stadium (1-2) | 35-36 | Won 4 |
| » W: Xavier Hernandez (1-0) L: Jim Corsi (0-1) S: David Wells (2) | Second | 7 out |
| Friday, June 23 |
| » Defeated Athletics (44-29), 10-8 | Oakland-Alameda County Stadium (2-2) | 36-36 | Won 5 |
| » W: De Wayne Buice (1-0) L: Curt Young (2-8) S: Tom Henke (3) | Second | 6 out |
| Saturday, June 24 |
| » Lost to Athletics (45-29), 7-1 | Oakland-Alameda County Stadium (2-3) | 36-37 | |
| » W: Dave Stewart (12-3) L: Dave Stieb (7-4) | Second | 6 out |
| » Major-league debuts: Steve Cummings (Blue Jays) |
| Sunday, June 25 |
| » Lost to Athletics (46-29), 6-3 | Oakland-Alameda County Stadium (2-4) | 36-38 | Lost 2 |
| » W: Storm Davis (6-3) L: Jimmy Key (7-7) S: Rick Honeycutt (8) | Third | 6 out |
| Tuesday, June 27 |
| » Lost to Orioles (42-31), 16-6 | Memorial Stadium (0-1) | 36-39 | Lost 3 |
| » W: Jay Tibbs (5-0) L: Mike Flanagan (4-6) | Third | 7 out |
| Wednesday, June 28 |
| » Lost to Orioles (43-31), 2-1 | Memorial Stadium (0-2) | 36-40 | Lost 4 |
| » W: Kevin Hickey (2-2) L: John Cerutti (3-4) S: Gregg Olson (12) | Fourth | 8 out |
| Thursday, June 29 |
| » Defeated Orioles (43-32), 11-1 | Memorial Stadium (1-2) | 37-40 | |
| » W: Steve Cummings (1-0) L: Dave Schmidt (7-7) | Third | 7 out |
| Friday, June 30 |
| » Lost to Red Sox (36-39), 3-1 | Skydome (6-5) | 37-41 | |
| » W: Mike Boddicker (5-7) L: David Wells (2-3) S: Rob Murphy (3) | Fourth | 7 out |
| Saturday, July 1 |
| » Lost to Red Sox (37-39), 3-1 | Skydome (6-6) | 37-42 | Lost 2 |
| » W: Eric Hetzel (1-0) L: Todd Stottlemyre (0-4) S: Lee Smith (10) | Fourth | 8 out |
| » Major-league debuts: Eric Hetzel (Red Sox) |
| Sunday, July 2 |
| » Lost to Red Sox (38-39), 4-1 | Skydome (6-7) | 37-43 | Lost 3 |
| » W: Rob Murphy (1-3) L: David Wells (2-4) S: Lee Smith (11) | Fifth | 8 out |
| Monday, July 3 |
| » Defeated Red Sox (38-40), 3-2 | Skydome (7-7) | 38-43 | |
| » W: John Cerutti (4-4) L: Mike Smithson (4-7) S: Duane Ward (6) | Fifth | 8 out |
| Tuesday, July 4 |
| » Lost to Orioles (46-34), 8-0 | Skydome (7-8) | 38-44 | |
| » W: Dave Schmidt (8-7) L: Dave Stieb (7-5) S: Mark Williamson (7) | Sixth | 9 out |
| Wednesday, July 5 |
| » Lost to Orioles (47-34), 5-4 | Skydome (7-9) | 38-45 | Lost 2 |
| » W: Bob Milacki (5-8) L: Jimmy Key (7-8) S: Gregg Olson (13) | Sixth | 10 out |
| Thursday, July 6 |
| » Defeated Orioles (47-35), 4-1 | Skydome (8-9) | 39-45 | |
| » W: Todd Stottlemyre (1-4) L: Jeff Ballard (10-4) S: Duane Ward (7) | Sixth | 9 out |
| Friday, July 7 |
| » Defeated Tigers (31-52), 6-4 | Tiger Stadium (1-0) | 40-45 | Won 2 |
| » W: Steve Cummings (2-0) L: Willie Hernandez (2-2) S: Tom Henke (4) | Sixth | 8 out |
| Saturday, July 8 |
| » Defeated Tigers (31-53), 8-3 | Tiger Stadium (2-0) | 41-45 | Won 3 |
| » W: John Cerutti (5-4) L: Doyle Alexander (4-9) S: Duane Ward (8) | Fourth | 8 out |
| Sunday, July 9 |
| » Defeated Tigers (31-54), 2-0 | Tiger Stadium (3-0) | 42-45 | Won 4 |
| » W: Dave Stieb (8-5) L: Frank Tanana (7-9) S: Tom Henke (5) | Fourth | 7 out |
| Thursday, July 13 |
| » Lost to Athletics (53-36), 11-7 | Skydome (8-10) | 42-46 | |
| » W: Todd Burns (5-2) L: Jimmy Key (7-9) | Fourth | 7 out |
| Friday, July 14 |
| » Defeated Athletics (53-37), 4-1 | Skydome (9-10) | 43-46 | |
| » W: Dave Stieb (9-5) L: Bob Welch (10-5) S: Duane Ward (9) | Fourth | 7 out |
| Saturday, July 15 |
| » Defeated Athletics (53-38), 6-1 | Skydome (10-10) | 44-46 | Won 2 |
| » W: Mike Flanagan (5-6) L: Dave Stewart (13-5) | Fourth | 7 out |
| Sunday, July 16 |
| » Lost to Athletics (54-38), 6-2 | Skydome (10-11) | 44-47 | |
| » W: Mike Moore (12-5) L: John Cerutti (5-5) S: Todd Burns (7) | Fourth | 8 out |
| Monday, July 17 |
| » Defeated Angels (53-37), 6-4 | Skydome (11-11) | 45-47 | |
| » W: David Wells (3-4) L: Jim Abbott (8-6) S: Tom Henke (6) | Third | 7½ out |
| » Defeated Angels (53-38), 5-4 | Skydome (12-11) | 46-47 | Won 2 |
| » W: David Wells (4-4) L: Bob McClure (2-1) S: Tom Henke (7) | Third | 7½ out |
| Tuesday, July 18 |
| » Lost to Angels (54-38), 1-0 | Skydome (12-12) | 46-48 | |
| » W: Bert Blyleven (10-2) L: Jimmy Key (7-10) | Third | 8½ out |
| Thursday, July 20 |
| » Lost to Mariners (47-47), 5-2 | Kingdome (1-2) | 46-49 | Lost 2 |
| » W: Scott Bankhead (10-4) L: Dave Stieb (9-6) S: Dennis Powell (2) | Fifth | 8 out |
| Friday, July 21 |
| » Defeated Mariners (47-48), 8-1 | Kingdome (2-2) | 47-49 | |
| » W: Mike Flanagan (6-6) L: Gene Harris (2-4) | Second | 7 out |
| Saturday, July 22 |
| » Defeated Mariners (47-49), 7-1 | Kingdome (3-2) | 48-49 | Won 2 |
| » W: John Cerutti (6-5) L: Mike Dunne (2-6) S: Duane Ward (10) | Second | 6 out |
| Sunday, July 23 |
| » Lost to Mariners (48-49), 5-2 | Kingdome (3-3) | 48-50 | |
| » W: Randy Johnson (4-6) L: Jimmy Key (7-11) | Third | 6 out |
| Monday, July 24 |
| » Defeated Rangers (54-44), 6-3 | Arlington Stadium (2-2) | 49-50 | |
| » W: Todd Stottlemyre (2-4) L: Wilson Alvarez (0-1) S: Tom Henke (8) | Third | 5½ out |
| » Major-league debuts: Wilson Alvarez (Rangers) Francisco Cabrera (Blue Jays) |
| Tuesday, July 25 |
| » Defeated Rangers (54-45), 4-0 | Arlington Stadium (3-2) | 50-50 | Won 2 |
| » W: Dave Stieb (10-6) L: Nolan Ryan (11-6) S: Duane Ward (11) | Second | 4½ out |
| Wednesday, July 26 |
| » Lost to Rangers (55-45), 11-1 | Arlington Stadium (3-3) | 50-51 | |
| » W: Kevin Brown (9-6) L: Mike Flanagan (6-7) | Third | 4½ out |
| Friday, July 28 |
| » Defeated Yankees (47-54), 6-2 | Yankee Stadium (3-1) | 51-51 | |
| » W: John Cerutti (7-5) L: Dave LaPoint (6-9) | Third | 4 out |
| Saturday, July 29 |
| » Lost to Yankees (48-54), 7-2 | Yankee Stadium (3-2) | 51-52 | |
| » W: Chuck Cary (1-0) L: Jimmy Key (7-12) | Third | 4 out |
| Sunday, July 30 |
| » Lost to Yankees (49-54), 7-6 | Yankee Stadium (3-3) | 51-53 | Lost 2 |
| » W: Lee Guetterman (3-5) L: Duane Ward (4-8) | Fourth | 4 out |
| Monday, July 31 |
| » Defeated Yankees (49-55), 6-5 | Yankee Stadium (4-3) | 52-53 | |
| » W: David Wells (5-4) L: Andy Hawkins (12-10) S: Tom Henke (9) | Third | 3 out |
| Tuesday, August 1 |
| » Lost to Royals (58-47), 2-1 | Skydome (12-13) | 52-54 | |
| » W: Bret Saberhagen (11-5) L: Todd Stottlemyre (2-5) | Third | 2½ out |
| Wednesday, August 2 |
| » Defeated Royals (58-48), 8-0 | Skydome (13-13) | 53-54 | |
| » W: John Cerutti (8-5) L: Mark Gubicza (9-9) | Third | 2½ out |
| Thursday, August 3 |
| » Lost to Royals (59-48), 5-0 | Skydome (13-14) | 53-55 | |
| » W: Tom Gordon (12-4) L: Jimmy Key (7-13) | Fourth | 3 out |
| Friday, August 4 |
| » Defeated Yankees (51-58), 2-1 | Skydome (14-14) | 54-55 | |
| » W: Dave Stieb (11-6) L: Clay Parker (3-2) | Third | 2 out |
| Saturday, August 5 |
| » Lost to Yankees (52-58), 5-4 | Skydome (14-15) | 54-56 | |
| » W: Andy Hawkins (13-10) L: Duane Ward (4-9) S: Dave Righetti (18) | Fourth | 3 out |
| Sunday, August 6 |
| » Defeated Yankees (52-59), 6-5 | Skydome (15-15) | 55-56 | |
| » W: Todd Stottlemyre (3-5) L: Walt Terrell (5-15) | Third | 3 out |
| Monday, August 7 |
| » Defeated Rangers (58-52), 2-1 | Skydome (16-15) | 56-56 | Won 2 |
| » W: John Cerutti (9-5) L: Mike Jeffcoat (5-5) | Second | 2 out |
| Tuesday, August 8 |
| » Defeated Rangers (58-53), 7-0 | Skydome (17-15) | 57-56 | Won 3 |
| » W: Mauro Gozzo (1-0) L: Bobby Witt (9-10) | Second | 2 out |
| » Major-league debuts: Mauro Gozzo (Blue Jays) |
| Wednesday, August 9 |
| » Lost to Rangers (59-53), 4-3 | Skydome (17-16) | 57-57 | |
| » W: Charlie Hough (7-11) L: Dave Stieb (11-7) S: Jeff Russell (24) | Second | 2 out |
| Thursday, August 10 |
| » Major-league debuts: Kevin Wickander (Indians) Greg Vaughn (Brewers) |
| Friday, August 11 |
| » Lost to Royals (63-51), 6-2 | Royals Stadium (1-3) | 57-58 | Lost 2 |
| » W: Bret Saberhagen (13-5) L: Mike Flanagan (6-8) | Third | 2½ out |
| Saturday, August 12 |
| » Defeated Royals (63-52), 2-0 | Royals Stadium (2-3) | 58-58 | |
| » W: Todd Stottlemyre (4-5) L: Mark Gubicza (10-10) S: Tom Henke (10) | Third | 1½ out |
| Sunday, August 13 |
| » Lost to Royals (64-52), 8-3 | Royals Stadium (2-4) | 58-59 | |
| » W: Tom Gordon (14-4) L: John Cerutti (9-6) | Third | 2½ out |
| Monday, August 14 |
| » Defeated Red Sox (57-59), 4-2 | Fenway Park (4-0) | 59-59 | |
| » W: Mauro Gozzo (2-0) L: Mike Boddicker (10-9) S: Tom Henke (11) | Second | 2½ out |
| Tuesday, August 15 |
| » Defeated Red Sox (57-60), 7-2 | Fenway Park (5-0) | 60-59 | Won 2 |
| » W: Dave Stieb (12-7) L: Mike Smithson (6-11) S: Duane Ward (12) | Third | 2½ out |
| Wednesday, August 16 |
| » Defeated Red Sox (57-61), 7-3 | Fenway Park (6-0) | 61-59 | Won 3 |
| » W: David Wells (6-4) L: Rob Murphy (3-6) S: Tom Henke (12) | Third | 1½ out |
| Thursday, August 17 |
| » Lost to Orioles (63-57), 11-6 | Memorial Stadium (1-3) | 61-60 | |
| » W: Jeff Ballard (12-6) L: John Cerutti (9-7) | Third | 2½ out |
| Friday, August 18 |
| » Defeated Orioles (63-58), 9-2 | Memorial Stadium (2-3) | 62-60 | |
| » W: Mauro Gozzo (3-0) L: Dave Johnson (2-2) | Third | 1½ out |
| Saturday, August 19 |
| » Defeated Orioles (63-59), 5-1 | Memorial Stadium (3-3) | 63-60 | Won 2 |
| » W: Jimmy Key (8-13) L: Bob Milacki (7-11) | Third | ½ out |
| Sunday, August 20 |
| » Lost to Orioles (64-59), 7-2 | Memorial Stadium (3-4) | 63-61 | |
| » W: Pete Harnisch (3-6) L: Dave Stieb (12-8) S: Mark Thurmond (4) | Third | 1½ out |
| Tuesday, August 22 |
| » Defeated Tigers (47-79), 3-2 | Skydome (18-16) | 64-61 | |
| » W: Mauro Gozzo (4-0) L: Edwin Nunez (2-3) | Second | 2 out |
| Wednesday, August 23 |
| » Defeated Tigers (47-80), 11-4 | Skydome (19-16) | 65-61 | Won 2 |
| » W: Frank Wills (1-1) L: Jeff Robinson (3-3) | Second | 2 out |
| Thursday, August 24 |
| » Defeated Tigers (47-81), 11-3 | Skydome (20-16) | 66-61 | Won 3 |
| » W: Mike Flanagan (7-8) L: Jack Morris (3-11) | Second | 1½ out |
| Friday, August 25 |
| » Defeated Brewers (65-65), 3-1 | Skydome (21-16) | 67-61 | Won 4 |
| » W: Jimmy Key (9-13) L: Jeff Peterek (0-1) S: Tom Henke (13) | Second | 1½ out |
| Saturday, August 26 |
| » Defeated Brewers (65-66), 7-0 | Skydome (22-16) | 68-61 | Won 5 |
| » W: Dave Stieb (13-8) L: Teddy Higuera (9-5) | Second | 1½ out |
| Sunday, August 27 |
| » Defeated Brewers (65-67), 5-4 | Skydome (23-16) | 69-61 | Won 6 |
| » W: Todd Stottlemyre (5-5) L: Chris Bosio (14-9) S: Duane Ward (13) | Second | 1½ out |
| Monday, August 28 |
| » Lost to Brewers (66-67), 8-2 | Skydome (23-17) | 69-62 | |
| » W: Tom Filer (5-2) L: John Cerutti (9-8) S: Bill Krueger (3) | Second | 2 out |
| Tuesday, August 29 |
| » Defeated White Sox (56-75), 3-2 | Skydome (24-17) | 70-62 | |
| » W: Mike Flanagan (8-8) L: Donn Pall (4-5) S: Tom Henke (14) | Second | 1 out |
| Wednesday, August 30 |
| » Defeated White Sox (56-76), 2-1 | Skydome (25-17) | 71-62 | Won 2 |
| » W: Jimmy Key (10-13) L: Richard Dotson (4-8) S: Duane Ward (14) | Second | 1 out |
| Thursday, August 31 |
| » Defeated White Sox (56-77), 5-1 | Skydome (26-17) | 72-62 | Won 3 |
| » W: Dave Stieb (14-8) L: Steve Rosenberg (4-10) | First | -- |
| Friday, September 1 |
| » Defeated Twins (68-66), 7-3 | Skydome (27-17) | 73-62 | Won 4 |
| » W: Todd Stottlemyre (6-5) L: Mark Guthrie (1-1) | First | -- |
| » Major-league debuts: Glenallen Hill (Blue Jays) Lenny Webster (Twins) |
| Saturday, September 2 |
| » Defeated Twins (68-67), 4-2 | Skydome (28-17) | 74-62 | Won 5 |
| » W: John Cerutti (10-8) L: Roy Smith (10-5) S: Tom Henke (15) | First | -- |
| Sunday, September 3 |
| » Lost to Twins (69-67), 9-4 | Skydome (28-18) | 74-63 | |
| » W: Rick Aguilera (7-9) L: Mike Flanagan (8-9) | First | -- |
| » Major-league debuts: John Olerud (Blue Jays) |
| Monday, September 4 |
| » Defeated White Sox (58-79), 5-2 | Comiskey Park I (4-0) | 75-63 | |
| » W: Jimmy Key (11-13) L: Richard Dotson (4-9) S: Tom Henke (16) | First | -- |
| Tuesday, September 5 |
| » Defeated White Sox (58-80), 6-1 | Comiskey Park I (5-0) | 76-63 | Won 2 |
| » W: Dave Stieb (15-8) L: Steve Rosenberg (4-11) | First | -- |
| Wednesday, September 6 |
| » Defeated White Sox (58-81), 4-2 | Comiskey Park I (6-0) | 77-63 | Won 3 |
| » W: Todd Stottlemyre (7-5) L: Eric King (7-9) S: Duane Ward (15) | First | -- |
| Thursday, September 7 |
| » Defeated Indians (64-76), 12-4 | Cleveland Stadium (1-3) | 78-63 | Won 4 |
| » W: John Cerutti (11-8) L: Tom Candiotti (12-8) | First | -- |
| Friday, September 8 |
| » Lost to Indians (65-76), 5-4 | Cleveland Stadium (1-4) | 78-64 | |
| » W: Doug Jones (7-8) L: Jim Acker (0-7) | First | -- |
| Saturday, September 9 |
| » Defeated Indians (65-77), 7-5 | Cleveland Stadium (2-4) | 79-64 | |
| » W: Frank Wills (2-1) L: Jeff Kaiser (0-1) | First | -- |
| Sunday, September 10 |
| » Defeated Indians (65-78), 5-4 | Cleveland Stadium (3-4) | 80-64 | Won 2 |
| » W: Jim Acker (1-7) L: Steve Olin (1-2) | First | -- |
| Tuesday, September 12 |
| » Lost to Twins (72-72), 8-2 | Hubert H. Humphrey Metrodome (0-4) | 80-65 | |
| » W: David West (3-3) L: Todd Stottlemyre (7-6) | First | -- |
| Wednesday, September 13 |
| » Lost to Twins (73-72), 3-2 | Hubert H. Humphrey Metrodome (0-5) | 80-66 | Lost 2 |
| » W: Kevin Tapani (2-0) L: John Cerutti (11-9) S: Jeff Reardon (29) | First | -- |
| Thursday, September 14 |
| » Lost to Twins (74-72), 2-0 | Hubert H. Humphrey Metrodome (0-6) | 80-67 | Lost 3 |
| » W: Mark Guthrie (2-1) L: Mike Flanagan (8-10) S: Jeff Reardon (30) | First | -- |
| Friday, September 15 |
| » Defeated Indians (67-80), 5-2 | Skydome (29-18) | 81-67 | |
| » W: Jimmy Key (12-13) L: Greg Swindell (13-5) S: Tom Henke (17) | First | -- |
| Saturday, September 16 |
| » Defeated Indians (67-81), 3-2 | Skydome (30-18) | 82-67 | Won 2 |
| » W: David Wells (7-4) L: Doug Jones (7-9) | First | -- |
| Sunday, September 17 |
| » Defeated Indians (67-82), 2-1 | Skydome (31-18) | 83-67 | Won 3 |
| » W: Jim Acker (2-7) L: Scott Bailes (4-9) | First | -- |
| Monday, September 18 |
| » Lost to Red Sox (74-76), 6-3 | Skydome (31-19) | 83-68 | |
| » W: Mike Boddicker (13-11) L: John Cerutti (11-10) S: Rob Murphy (8) | First | -- |
| Tuesday, September 19 |
| » Defeated Red Sox (74-77), 6-5 | |