| Monday, April 3 |
| » Major-league debuts: Omar Vizquel (Mariners) |
| Tuesday, April 4 |
| » Defeated Braves (0-1), 10-3 | Astrodome (1-0) | 1-0 | |
| » W: Mike Scott (1-0) L: Zane Smith (0-1) | Second | ½ out |
| Wednesday, April 5 |
| » Lost to Braves (1-1), 8-4 | Astrodome (1-1) | 1-1 | |
| » W: Jose Alvarez (1-0) L: Bob Knepper (0-1) S: Joe Boever (1) | Third | 1 out |
| » Major-league debuts: Geronimo Berroa (Braves) |
| Thursday, April 6 |
| » Lost to Braves (2-1), 3-2 | Astrodome (1-2) | 1-2 | Lost 2 |
| » W: John Smoltz (1-0) L: Jim Deshaies (0-1) S: Joe Boever (2) | Second | 1 out |
| Friday, April 7 |
| » Lost to Padres (2-2), 5-3 | Astrodome (1-3) | 1-3 | Lost 3 |
| » W: Dennis Rasmussen (1-0) L: Rick Rhoden (0-1) S: Mark Davis (2) | Third | 2 out |
| Saturday, April 8 |
| » Defeated Padres (2-3), 6-2 | Astrodome (2-3) | 2-3 | |
| » W: Jim Clancy (1-0) L: Walt Terrell (0-1) | Third | 1½ out |
| Sunday, April 9 |
| » Lost to Padres (3-3), 5-4 | Astrodome (2-4) | 2-4 | |
| » W: Eric Show (1-1) L: Mike Scott (1-1) S: Mark Davis (3) | Fourth | 1½ out |
| » Major-league debuts: Eric Yelding (Astros) |
| Monday, April 10 |
| » Lost to Reds (4-2), 8-3 | Astrodome (2-5) | 2-5 | Lost 2 |
| » W: Tom Browning (2-0) L: Bob Knepper (0-2) S: Rob Dibble (1) | Fourth | 2½ out |
| Tuesday, April 11 |
| » Defeated Reds (4-3), 5-3 | Astrodome (3-5) | 3-5 | |
| » W: Jim Deshaies (1-1) L: Rick Mahler (0-2) S: Dave Smith (1) | Fourth | 2 out |
| Wednesday, April 12 |
| » Lost to Reds (5-3), 3-1 | Astrodome (3-6) | 3-6 | |
| » W: Rob Dibble (1-0) L: Dave Smith (0-1) S: John Franco (3) | Fifth | 2½ out |
| Thursday, April 13 |
| » Defeated Dodgers (3-6), 4-2 | Dodger Stadium (1-0) | 4-6 | |
| » W: Bob Forsch (1-0) L: Ray Searage (0-1) | Fourth | 2 out |
| Friday, April 14 |
| » Defeated Dodgers (3-7), 3-2 | Dodger Stadium (2-0) | 5-6 | Won 2 |
| » W: Mike Scott (2-1) L: Mike Morgan (0-1) | Fifth | 2 out |
| Saturday, April 15 |
| » Lost to Dodgers (4-7), 3-1 | Dodger Stadium (2-1) | 5-7 | |
| » W: Orel Hershiser (2-1) L: Bob Knepper (0-3) S: Alejandro Pena (2) | Fifth | 3 out |
| Sunday, April 16 |
| » Lost to Dodgers (5-7), 2-1 | Dodger Stadium (2-2) | 5-8 | Lost 2 |
| » W: Tim Leary (2-1) L: Jim Deshaies (1-2) | Fifth | 3½ out |
| Tuesday, April 18 |
| » Lost to Braves (7-7), 5-4 | Atlanta-Fulton County Stadium (0-1) | 5-9 | Lost 3 |
| » W: Joe Boever (1-0) L: Dave Smith (0-2) | Sixth | 4 out |
| Wednesday, April 19 |
| » Lost to Braves (8-7), 4-3 | Atlanta-Fulton County Stadium (0-2) | 5-10 | Lost 4 |
| » W: Jose Alvarez (2-0) L: Jim Clancy (1-1) S: Joe Boever (4) | Sixth | 4 out |
| Thursday, April 20 |
| » Defeated Braves (8-8), 4-3 | Atlanta-Fulton County Stadium (1-2) | 6-10 | |
| » W: Danny Darwin (1-0) L: Paul Assenmacher (0-1) S: Dave Smith (2) | Fifth | 3½ out |
| Friday, April 21 |
| » Defeated Reds (8-7), 7-0 | Riverfront Stadium (1-0) | 7-10 | Won 2 |
| » W: Jim Deshaies (2-2) L: Rick Mahler (1-3) | Sixth | 2½ out |
| Saturday, April 22 |
| » Lost to Reds (9-7), 5-4 | Riverfront Stadium (1-1) | 7-11 | |
| » W: Tim Birtsas (2-0) L: Danny Darwin (1-1) | Fifth | 3½ out |
| Sunday, April 23 |
| » Defeated Reds (9-8), 5-2 | Riverfront Stadium (2-1) | 8-11 | |
| » W: Bob Knepper (1-3) L: Danny Jackson (1-4) S: Larry Andersen (1) | Sixth | 2½ out |
| Monday, April 24 |
| » Lost to Phillies (10-8), 8-4 | Astrodome (3-7) | 8-12 | |
| » W: Greg Harris (1-0) L: Bob Forsch (1-1) | Fifth | 3 out |
| Tuesday, April 25 |
| » Defeated Phillies (10-9), 4-1 | Astrodome (4-7) | 9-12 | |
| » W: Mike Scott (3-1) L: Ken Howell (2-1) | Sixth | 3 out |
| Wednesday, April 26 |
| » Defeated Phillies (10-10), 6-5 | Astrodome (5-7) | 10-12 | Won 2 |
| » W: Danny Darwin (2-1) L: Jeff Parrett (1-1) S: Dave Smith (3) | Fourth | 2½ out |
| Friday, April 28 |
| » Lost to Mets (11-9), 7-3 | Astrodome (5-8) | 10-13 | |
| » W: Sid Fernandez (3-0) L: Rick Rhoden (0-2) S: Roger McDowell (3) | Fourth | 3½ out |
| Saturday, April 29 |
| » Lost to Mets (12-9), 5-1 | Astrodome (5-9) | 10-14 | Lost 2 |
| » W: Ron Darling (1-3) L: Bob Knepper (1-4) S: Randy Myers (5) | Fifth | 3½ out |
| Sunday, April 30 |
| » Defeated Mets (12-10), 7-6 | Astrodome (6-9) | 11-14 | |
| » W: Mike Scott (4-1) L: David Cone (2-2) S: Dave Smith (4) | Fifth | 3½ out |
| Monday, May 1 |
| » Major-league debuts: Dwight Smith (Cubs) |
| Tuesday, May 2 |
| » Defeated Phillies (11-13), 12-4 | Veteran's Stadium (1-0) | 12-14 | Won 2 |
| » W: Jim Deshaies (3-2) L: Floyd Youmans (1-3) | Fourth | 3 out |
| Wednesday, May 3 |
| » Lost to Expos (15-12), 6-5 | Stade Olympique (0-1) | 12-15 | |
| » W: Tim Burke (3-1) L: Juan Agosto (0-1) | Fifth | 4 out |
| Thursday, May 4 |
| » Defeated Expos (15-13), 5-4 | Stade Olympique (1-1) | 13-15 | |
| » W: Danny Darwin (3-1) L: Joe Hesketh (3-1) S: Dave Smith (5) | Fourth | 3 out |
| Saturday, May 6 |
| » Lost to Mets (16-11), 2-1 | Shea Stadium (0-1) | 13-16 | |
| » W: David Cone (3-2) L: Jim Clancy (1-2) | Fifth | 3½ out |
| Sunday, May 7 |
| » Defeated Mets (16-12), 5-0 | Shea Stadium (1-1) | 14-16 | |
| » W: Jim Deshaies (4-2) L: Dwight Gooden (5-1) | Sixth | 2½ out |
| Monday, May 8 |
| » Lost to Expos (16-16), 4-1 | Astrodome (6-10) | 14-17 | |
| » W: Kevin Gross (4-2) L: Bob Knepper (1-5) | Sixth | 3½ out |
| Tuesday, May 9 |
| » Lost to Expos (17-16), 4-2 | Astrodome (6-11) | 14-18 | Lost 2 |
| » W: Dennis Martinez (2-1) L: Mike Scott (4-2) S: Tim Burke (7) | Sixth | 3½ out |
| Wednesday, May 10 |
| » Lost to Expos (18-16), 10-1 | Astrodome (6-12) | 14-19 | Lost 3 |
| » W: Bryn Smith (3-1) L: Jim Clancy (1-3) | Sixth | 4 out |
| » Major-league debuts: Steve Frey (Expos) |
| Friday, May 12 |
| » Defeated Cubs (17-16), 3-1 | Wrigley Field (1-0) | 15-19 | |
| » W: Jim Deshaies (5-2) L: Rick Sutcliffe (4-3) | Sixth | 4 out |
| Saturday, May 13 |
| » Defeated Cubs (17-17), 1-0 | Wrigley Field (2-0) | 16-19 | Won 2 |
| » W: Bob Knepper (2-5) L: Greg Maddux (1-5) S: Dave Smith (6) | Fifth | 3½ out |
| Sunday, May 14 |
| » Defeated Cubs (17-18), 5-1 | Wrigley Field (3-0) | 17-19 | Won 3 |
| » W: Mike Scott (5-2) L: Paul Kilgus (3-4) | Fourth | 3½ out |
| Tuesday, May 16 |
| » Defeated Cardinals (19-17), 8-7 | Astrodome (7-12) | 18-19 | Won 4 |
| » W: Dan Schatzeder (1-0) L: Cris Carpenter (1-3) | Fifth | 3 out |
| Wednesday, May 17 |
| » Defeated Cardinals (19-18), 3-2 | Astrodome (8-12) | 19-19 | Won 5 |
| » W: Larry Andersen (1-0) L: Joe Magrane (3-3) | Fourth | 3 out |
| Thursday, May 18 |
| » Lost to Cardinals (20-18), 4-3 | Astrodome (8-13) | 19-20 | |
| » W: Ken Dayley (2-1) L: Larry Andersen (1-1) | Fourth | 3½ out |
| Friday, May 19 |
| » Defeated Pirates (15-23), 3-0 | Astrodome (9-13) | 20-20 | |
| » W: Mike Scott (6-2) L: Bob Walk (4-3) | Fifth | 2½ out |
| Saturday, May 20 |
| » Defeated Pirates (15-24), 5-4 | Astrodome (10-13) | 21-20 | Won 2 |
| » W: Juan Agosto (1-1) L: Bob Kipper (0-1) | Fifth | 1½ out |
| Sunday, May 21 |
| » Lost to Pirates (16-24), 17-5 | Astrodome (10-14) | 21-21 | |
| » W: Neal Heaton (1-4) L: Jim Clancy (1-4) S: Brian Fisher (1) | Fifth | 2½ out |
| Monday, May 22 |
| » Lost to Cubs (23-19), 5-3 | Astrodome (10-15) | 21-22 | Lost 2 |
| » W: Rick Sutcliffe (5-3) L: Jim Deshaies (5-3) S: Calvin Schiraldi (3) | Fifth | 3 out |
| Tuesday, May 23 |
| » Lost to Cubs (24-19), 5-4 | Astrodome (10-16) | 21-23 | Lost 3 |
| » W: Scott Sanderson (5-2) L: Mike Scott (6-3) S: Calvin Schiraldi (4) | Fifth | 4 out |
| Wednesday, May 24 |
| » Lost to Cubs (25-19), 3-1 | Astrodome (10-17) | 21-24 | Lost 4 |
| » W: Greg Maddux (3-5) L: Bob Knepper (2-6) S: Mitch Williams (12) | Fifth | 5 out |
| Friday, May 26 |
| » Defeated Pirates (19-25), 4-2 | Three Rivers Stadium (1-0) | 22-24 | |
| » W: Jim Clancy (2-4) L: Neal Heaton (1-5) S: Dave Smith (7) | Fifth | 5 out |
| Saturday, May 27 |
| » Defeated Pirates (19-26), 5-4 | Three Rivers Stadium (2-0) | 23-24 | Won 2 |
| » W: Dan Schatzeder (2-0) L: Jeff Robinson (2-5) S: Dave Smith (8) | Fifth | 4 out |
| Sunday, May 28 |
| » Defeated Pirates (19-27), 9-2 | Three Rivers Stadium (3-0) | 24-24 | Won 3 |
| » W: Mike Scott (7-3) L: John Smiley (5-2) S: Juan Agosto (1) | Fifth | 3 out |
| Monday, May 29 |
| » Defeated Cardinals (23-23), 3-2 | Busch Stadium II (1-0) | 25-24 | Won 4 |
| » W: Bob Knepper (3-6) L: Ken Hill (2-4) S: Dave Smith (9) | Fifth | 3 out |
| Tuesday, May 30 |
| » Defeated Cardinals (23-24), 8-4 | Busch Stadium II (2-0) | 26-24 | Won 5 |
| » W: Danny Darwin (4-1) L: Scott Terry (4-4) | Fourth | 3 out |
| Wednesday, May 31 |
| » Defeated Cardinals (23-25), 4-3 | Busch Stadium II (3-0) | 27-24 | Won 6 |
| » W: Dan Schatzeder (3-0) L: Cris Carpenter (1-4) S: Dave Smith (10) | Fourth | 2 out |
| Thursday, June 1 |
| » Defeated Dodgers (25-25), 7-2 | Astrodome (11-17) | 28-24 | Won 7 |
| » W: Jim Deshaies (6-3) L: Mike Morgan (4-3) | Third | 1½ out |
| Friday, June 2 |
| » Defeated Dodgers (25-26), 1-0 | Astrodome (12-17) | 29-24 | Won 8 |
| » W: Mike Scott (8-3) L: Fernando Valenzuela (0-5) | Third | 1½ out |
| Saturday, June 3 |
| » Defeated Dodgers (25-27), 5-4 | Astrodome (13-17) | 30-24 | Won 9 |
| » W: Jim Clancy (3-4) L: Jeff Hamilton (0-1) | Third | 1½ out |
| Sunday, June 4 |
| » Defeated Dodgers (25-28), 7-6 | Astrodome (14-17) | 31-24 | Won 10 |
| » W: Mike Scott (9-3) L: Alejandro Pena (2-2) | Third | 1½ out |
| Monday, June 5 |
| » Lost to Padres (30-28), 10-2 | Astrodome (14-18) | 31-25 | |
| » W: Ed Whitson (9-2) L: Mark Portugal (0-1) | Third | 1½ out |
| Tuesday, June 6 |
| » Defeated Padres (30-29), 8-7 | Astrodome (15-18) | 32-25 | |
| » W: Dave Smith (1-2) L: Mark Davis (2-1) | Third | 1 out |
| Wednesday, June 7 |
| » Defeated Padres (30-30), 3-2 | Astrodome (16-18) | 33-25 | Won 2 |
| » W: Mike Scott (10-3) L: Walt Terrell (4-7) S: Dave Smith (11) | Second | 1 out |
| Thursday, June 8 |
| » Defeated Padres (30-31), 7-6 | Astrodome (17-18) | 34-25 | Won 3 |
| » W: Danny Darwin (5-1) L: Mark Davis (2-2) | Second | 1 out |
| Friday, June 9 |
| » Defeated Braves (24-35), 6-5 | Astrodome (18-18) | 35-25 | Won 4 |
| » W: Juan Agosto (2-1) L: Jose Alvarez (3-2) S: Danny Darwin (1) | Second | 1 out |
| Saturday, June 10 |
| » Defeated Braves (24-36), 1-0 | Astrodome (19-18) | 36-25 | Won 5 |
| » W: Jim Clancy (4-4) L: John Smoltz (7-5) S: Dave Smith (12) | Second | 1 out |
| Sunday, June 11 |
| » Defeated Braves (24-37), 10-6 | Astrodome (20-18) | 37-25 | Won 6 |
| » W: Jim Deshaies (7-3) L: Tom Glavine (6-3) S: Danny Darwin (2) | First | -- |
| Tuesday, June 13 |
| » Lost to Dodgers (31-31), 3-2 | Dodger Stadium (2-3) | 37-26 | |
| » W: Fernando Valenzuela (2-5) L: Mike Scott (10-4) S: Jay Howell (13) | First | -- |
| Wednesday, June 14 |
| » Lost to Dodgers (32-31), 3-0 | Dodger Stadium (2-4) | 37-27 | Lost 2 |
| » W: Orel Hershiser (8-5) L: Bob Knepper (3-7) | Second | 1 out |
| Thursday, June 15 |
| » Lost to Dodgers (33-31), 2-1 | Dodger Stadium (2-5) | 37-28 | Lost 3 |
| » W: John Wetteland (1-0) L: Juan Agosto (2-2) | Second | 1 out |
| Friday, June 16 |
| » Defeated Padres (32-36), 3-1 | San Diego/Jack Murphy Stadium (1-0) | 38-28 | |
| » W: Jim Clancy (5-4) L: Ed Whitson (9-4) S: Dave Smith (13) | First | -- |
| Saturday, June 17 |
| » Lost to Padres (33-36), 2-1 | San Diego/Jack Murphy Stadium (1-1) | 38-29 | |
| » W: Greg Harris (3-2) L: Danny Darwin (5-2) | Second | 1 out |
| Sunday, June 18 |
| » Defeated Padres (33-37), 5-2 | San Diego/Jack Murphy Stadium (2-1) | 39-29 | |
| » W: Mike Scott (11-4) L: Walt Terrell (4-9) | Second | 1 out |
| Monday, June 19 |
| » Lost to Giants (41-28), 3-2 | Candlestick Park (0-1) | 39-30 | |
| » W: Don Robinson (6-4) L: Bob Knepper (3-8) S: Steve Bedrosian (7) | Second | 2 out |
| Tuesday, June 20 |
| » Lost to Giants (42-28), 4-0 | Candlestick Park (0-2) | 39-31 | Lost 2 |
| » W: Scott Garrelts (6-2) L: Bob Forsch (1-2) S: Craig Lefferts (14) | Second | 3 out |
| Wednesday, June 21 |
| » Lost to Giants (43-28), 2-0 | Candlestick Park (0-3) | 39-32 | Lost 3 |
| » W: Rick Reuschel (12-2) L: Jim Clancy (5-5) S: Steve Bedrosian (8) | Second | 4 out |
| Friday, June 23 |
| » Defeated Braves (29-42), 5-2 | Atlanta-Fulton County Stadium (2-2) | 40-32 | |
| » W: Danny Darwin (6-2) L: Paul Assenmacher (0-2) S: Dave Smith (14) | Second | 4 out |
| Saturday, June 24 |
| » Defeated Braves (29-43), 5-4 | Atlanta-Fulton County Stadium (3-2) | 41-32 | Won 2 |
| » W: Mike Scott (12-4) L: Jose Alvarez (3-3) S: Dave Smith (15) | Second | 4 out |
| Sunday, June 25 |
| » Defeated Braves (29-44), 12-6 | Atlanta-Fulton County Stadium (4-2) | 42-32 | Won 3 |
| » W: Dan Schatzeder (4-0) L: Jim Acker (0-3) S: Danny Darwin (3) | Second | 3 out |
| Monday, June 26 |
| » Lost to Giants (46-29), 4-3 | Astrodome (20-19) | 42-33 | |
| » W: Craig Lefferts (2-3) L: Juan Agosto (2-3) S: Steve Bedrosian (11) | Second | 4 out |
| Tuesday, June 27 |
| » Defeated Giants (46-30), 7-5 | Astrodome (21-19) | 43-33 | |
| » W: Danny Darwin (7-2) L: Steve Bedrosian (2-4) | Second | 3 out |
| Wednesday, June 28 |
| » Defeated Giants (46-31), 7-3 | Astrodome (22-19) | 44-33 | Won 2 |
| » W: Jim Deshaies (8-3) L: Don Robinson (7-5) | Second | 2 out |
| Thursday, June 29 |
| » Defeated Expos (43-35), 8-3 | Stade Olympique (2-1) | 45-33 | Won 3 |
| » W: Mike Scott (13-4) L: Kevin Gross (7-7) | Second | 2 out |
| Friday, June 30 |
| » Lost to Expos (44-35), 6-1 | Stade Olympique (2-2) | 45-34 | |
| » W: Dennis Martinez (8-1) L: Bob Knepper (3-9) | Second | 2 out |
| Saturday, July 1 |
| » Defeated Expos (44-36), 4-1 | Stade Olympique (3-2) | 46-34 | |
| » W: Larry Andersen (2-1) L: Pascual Perez (4-9) S: Dave Smith (16) | Second | 1 out |
| Sunday, July 2 |
| » Lost to Expos (45-36), 13-2 | Stade Olympique (3-3) | 46-35 | |
| » W: Bryn Smith (8-3) L: Jim Clancy (5-6) | Second | 2 out |
| Monday, July 3 |
| » Lost to Mets (42-36), 3-1 | Astrodome (22-20) | 46-36 | Lost 2 |
| » W: David Cone (5-5) L: Jim Deshaies (8-4) S: Randy Myers (12) | Second | 2½ out |
| Tuesday, July 4 |
| » Defeated Mets (42-37), 10-3 | Astrodome (23-20) | 47-36 | |
| » W: Mike Scott (14-4) L: Bob Ojeda (5-8) | Second | 1½ out |
| » Major-league debuts: Kevin Tapani (Mets) |
| Wednesday, July 5 |
| » Defeated Mets (42-38), 6-5 | Astrodome (24-20) | 48-36 | Won 2 |
| » W: Danny Darwin (8-2) L: Ron Darling (6-6) S: Dave Smith (17) | Second | 1½ out |
| Friday, July 7 |
| » Lost to Expos (48-37), 11-8 | Astrodome (24-21) | 48-37 | |
| » W: Joe Hesketh (5-2) L: Juan Agosto (2-4) S: Zane Smith (1) | Second | 2 out |
| Saturday, July 8 |
| » Defeated Expos (48-38), 3-2 | Astrodome (25-21) | 49-37 | |
| » W: Danny Darwin (9-2) L: Andy McGaffigan (1-4) S: Dave Smith (18) | Second | 2 out |
| Sunday, July 9 |
| » Lost to Expos (49-38), 6-1 | Astrodome (25-22) | 49-38 | |
| » W: Mark Langston (10-7) L: Mike Scott (14-5) | Second | 2 out |
| Thursday, July 13 |
| » Lost to Phillies (33-52), 11-4 | Veteran's Stadium (1-1) | 49-39 | Lost 2 |
| » W: Bruce Ruffin (3-3) L: Bob Knepper (3-10) S: Greg Harris (1) | Second | 2½ out |
| » Defeated Phillies (33-53), 3-0 | Veteran's Stadium (2-1) | 50-39 | |
| » W: Bob Forsch (2-2) L: Dennis Cook (3-3) S: Dave Smith (19) | Second | 2½ out |
| Friday, July 14 |
| » Lost to Phillies (34-53), 4-2 | Veteran's Stadium (2-2) | 50-40 | |
| » W: Jeff Parrett (6-3) L: Larry Andersen (2-2) | Second | 2½ out |
| Saturday, July 15 |
| » Defeated Phillies (34-54), 9-6 | Veteran's Stadium (3-2) | 51-40 | |
| » W: Mark Portugal (1-1) L: Larry McWilliams (2-9) | Second | 2½ out |
| Monday, July 17 |
| » Defeated Mets (47-42), 6-0 | Shea Stadium (2-1) | 52-40 | Won 2 |
| » W: Jim Deshaies (9-4) L: Ron Darling (7-7) | Second | 2½ out |
| » Defeated Mets (47-43), 12-3 | Shea Stadium (3-1) | 53-40 | Won 3 |
| » W: Bob Knepper (4-10) L: David West (0-2) S: Danny Darwin (4) | Second | 2½ out |
| » Major-league debuts: Wally Whitehurst (Mets) |
| Tuesday, July 18 |
| » Lost to Mets (48-43), 9-0 | Shea Stadium (3-2) | 53-41 | |
| » W: Sid Fernandez (8-3) L: Bob Forsch (2-3) | Second | 3½ out |
| Wednesday, July 19 |
| » Lost to Mets (49-43), 8-2 | Shea Stadium (3-3) | 53-42 | Lost 2 |
| » W: David Cone (7-5) L: Jim Clancy (5-7) | Second | 4½ out |
| Friday, July 21 |
| » Defeated Phillies (37-55), 4-2 | Astrodome (26-22) | 54-42 | |
| » W: Mike Scott (15-5) L: Terry Mulholland (1-4) S: Dave Smith (20) | Second | 4 out |
| Saturday, July 22 |
| » Defeated Phillies (37-56), 1-0 | Astrodome (27-22) | 55-42 | Won 2 |
| » W: Jim Deshaies (10-4) L: Ken Howell (8-6) S: Dave Smith (21) | Second | 2½ out |
| » Defeated Phillies (37-57), 4-3 | Astrodome (28-22) | 56-42 | Won 3 |
| » W: Danny Darwin (10-2) L: Larry McWilliams (2-10) | Second | 2½ out |
| Sunday, July 23 |
| » Defeated Phillies (37-58), 3-2 | Astrodome (29-22) | 57-42 | Won 4 |
| » W: Bob Forsch (3-3) L: Bruce Ruffin (3-4) S: Larry Andersen (2) | Second | 1½ out |
| Tuesday, July 25 |
| » Lost to Dodgers (47-54), 6-0 | Astrodome (29-23) | 57-43 | |
| » W: Tim Belcher (7-9) L: Rick Rhoden (0-3) | Second | 3 out |
| Wednesday, July 26 |
| » Defeated Dodgers (47-55), 6-2 | Astrodome (30-23) | 58-43 | |
| » W: Mike Scott (16-5) L: Fernando Valenzuela (5-10) | Second | 2 out |
| Thursday, July 27 |
| » Lost to Dodgers (48-55), 7-5 | Astrodome (30-24) | 58-44 | |
| » W: Mike Morgan (7-11) L: Larry Andersen (2-3) S: Jay Howell (20) | Second | 2 out |
| Friday, July 28 |
| » Lost to Giants (61-42), 3-2 | Astrodome (30-25) | 58-45 | Lost 2 |
| » W: Don Robinson (9-7) L: Jim Clancy (5-8) | Second | 3 out |
| Saturday, July 29 |
| » Defeated Giants (61-43), 8-1 | Astrodome (31-25) | 59-45 | |
| » W: Mark Portugal (2-1) L: Rick Reuschel (13-5) | Second | 2 out |
| » Major-league debuts: Eric Anthony (Astros) |
| Sunday, July 30 |
| » Defeated Giants (61-44), 6-2 | Astrodome (32-25) | 60-45 | Won 2 |
| » W: Mike Scott (17-5) L: Mike LaCoss (5-7) | Second | 1 out |
| Tuesday, August 1 |
| » Defeated Reds (48-57), 5-0 | Riverfront Stadium (3-1) | 61-45 | Won 3 |
| » W: Rick Rhoden (1-3) L: Tim Leary (7-9) | Second | 1 out |
| Wednesday, August 2 |
| » Lost to Reds (49-57), 5-2 | Riverfront Stadium (3-2) | 61-46 | |
| » W: Ron Robinson (1-1) L: Jim Deshaies (10-5) S: John Franco (25) | Second | 1 out |
| Thursday, August 3 |
| » Lost to Reds (50-57), 18-2 | Riverfront Stadium (3-3) | 61-47 | Lost 2 |
| » W: Tom Browning (9-10) L: Jim Clancy (5-9) | Second | 1 out |
| Friday, August 4 |
| » Lost to Giants (63-46), 4-2 | Candlestick Park (0-4) | 61-48 | Lost 3 |
| » W: Don Robinson (10-7) L: Danny Darwin (10-3) | Second | 2 out |
| Saturday, August 5 |
| » Lost to Giants (64-46), 7-0 | Candlestick Park (0-5) | 61-49 | Lost 4 |
| » W: Mike LaCoss (6-7) L: Mike Scott (17-6) | Second | 3 out |
| Sunday, August 6 |
| » Defeated Giants (64-47), 3-2 | Candlestick Park (1-5) | 62-49 | |
| » W: Juan Agosto (3-4) L: Craig Lefferts (2-4) S: Dave Smith (22) | Second | 2 out |
| Monday, August 7 |
| » Lost to Padres (56-56), 5-2 | San Diego/Jack Murphy Stadium (2-2) | 62-50 | |
| » W: Bruce Hurst (11-8) L: Jim Deshaies (10-6) | Second | 2 out |
| Tuesday, August 8 |
| » Defeated Padres (56-57), 12-3 | San Diego/Jack Murphy Stadium (3-2) | 63-50 | |
| » W: Jim Clancy (6-9) L: Don Schulze (3-2) | Second | 1 out |
| Wednesday, August 9 |
| » Lost to Padres (57-57), 2-1 | San Diego/Jack Murphy Stadium (3-3) | 63-51 | |
| » W: Mark Davis (3-3) L: Dave Smith (1-3) | Second | 2 out |
| Thursday, August 10 |
| » Lost to Padres (58-57), 13-3 | San Diego/Jack Murphy Stadium (3-4) | 63-52 | Lost 2 |
| » W: Greg Harris (5-6) L: Bob Forsch (3-4) | Second | 3 out |
| Friday, August 11 |
| » Lost to Reds (55-60), 6-1 | Astrodome (32-26) | 63-53 | Lost 3 |
| » W: Tim Leary (8-9) L: Rick Rhoden (1-4) S: Rob Dibble (2) | Second | 4 out |
| Saturday, August 12 |
| » Defeated Reds (55-61), 6-5 | Astrodome (33-26) | 64-53 | |
| » W: Dave Smith (2-3) L: John Franco (3-5) | Second | 3 out |
| Sunday, August 13 |
| » Lost to Reds (56-61), 5-0 | Astrodome (33-27) | 64-54 | |
| » W: Tom Browning (11-10) L: Jim Clancy (6-10) | Second | 3 out |
| Tuesday, August 15 |
| » Defeated Pirates (50-68), 3-2 | Astrodome (34-27) | 65-54 | |
| » W: Larry Andersen (3-3) L: Mike Smith (0-1) | Second | 3 out |
| Wednesday, August 16 |
| » Lost to Pirates (51-68), 5-4 | Astrodome (34-28) | 65-55 | |
| » W: Neal Heaton (3-7) L: Larry Andersen (3-4) S: Bill Landrum (17) | Second | 3 out |
| Thursday, August 17 |
| » Defeated Pirates (51-69), 5-3 | Astrodome (35-28) | 66-55 | |
| » W: Jim Deshaies (11-6) L: Jeff Robinson (5-11) | Second | 3 out |
| Friday, August 18 |
| » Defeated Cubs (71-51), 6-5 | Astrodome (36-28) | 67-55 | Won 2 |
| » W: Dave Smith (3-3) L: Calvin Schiraldi (3-5) | Second | 3 out |
| Saturday, August 19 |
| » Defeated Cubs (71-52), 8-4 | Astrodome (37-28) | 68-55 | Won 3 |
| » W: Mark Portugal (3-1) L: Greg Maddux (14-9) | Second | 2 out |
| Sunday, August 20 |
| » Defeated Cubs (71-53), 8-4 | Astrodome (38-28) | 69-55 | Won 4 |
| » W: Danny Darwin (11-3) L: Les Lancaster (3-1) | Second | 2 out |
| Tuesday, August 22 |
| » Lost to Pirates (53-71), 4-1 | Three Rivers Stadium (3-1) | 69-56 | |
| » W: John Smiley (10-7) L: Jim Deshaies (11-7) | Second | 2½ out |
| Wednesday, August 23 |
| » Lost to Pirates (54-71), 6-1 | Three Rivers Stadium (3-2) | 69-57 | Lost 2 |
| » W: Bob Walk (11-8) L: Jim Clancy (6-11) | Second | 3½ out |
| Thursday, August 24 |
| » Lost to Pirates (55-71), 3-2 | Three Rivers Stadium (3-3) | 69-58 | Lost 3 |
| » W: Doug Bair (2-2) L: Juan Agosto (3-5) | Second | 4 out |
| Friday, August 25 |
| » Lost to Cardinals (69-58), 7-4 | Astrodome (38-29) | 69-59 | Lost 4 |
| » W: Jose DeLeon (14-11) L: Mike Scott (17-7) | Second | 4 out |
| Saturday, August 26 |
| » Lost to Cardinals (70-58), 5-3 | Astrodome (38-30) | 69-60 | Lost 5 |
| » W: Ken Hill (7-10) L: Rick Rhoden (1-5) S: Todd Worrell (19) | Second | 5 out |
| Sunday, August 27 |
| » Defeated Cardinals (70-59), 6-3 | Astrodome (39-30) | 70-60 | |
| » W: Bob Forsch (4-4) L: Ted Power (5-6) S: Dave Smith (23) | Second | 4 out |
| Monday, August 28 |
| » Lost to Cubs (74-57), 6-1 | Wrigley Field (3-1) | 70-61 | |
| » W: Greg Maddux (15-10) L: Jose Cano (0-1) | Second | 4 out |
| Tuesday, August 29 |
| » Lost to Cubs (75-57), 10-9 | Wrigley Field (3-2) | 70-62 | Lost 2 |
| » W: Paul Assenmacher (2-3) L: Dave Smith (3-4) | Second | 4 out |
| Wednesday, August 30 |
| » Defeated Cubs (75-58), 8-4 | Wrigley Field (4-2) | 71-62 | |
| » W: Mike Scott (18-7) L: Rick Sutcliffe (13-11) | Second | 4 out |
| Friday, September 1 |
| » Defeated Cardinals (72-61), 6-3 | Busch Stadium II (4-0) | 72-62 | Won 2 |
| » W: Jim Deshaies (12-7) L: John Costello (3-3) | Second | 4 out |
| Saturday, September 2 |
| » Lost to Cardinals (73-61), 13-5 | Busch Stadium II (4-1) | 72-63 | |
| » W: Ted Power (6-6) L: Bob Forsch (4-5) | Second | 5 out |
| Sunday, September 3 |
| » Lost to Cardinals (74-61), 4-3 | Busch Stadium II (4-2) | 72-64 | Lost 2 |
| » W: Todd Worrell (3-5) L: Danny Darwin (11-4) | Second | 6 out |
| Monday, September 4 |
| » Lost to Dodgers (65-72), 7-5 | Astrodome (39-31) | 72-65 | Lost 3 |
| » W: Mike Morgan (8-11) L: Mike Scott (18-8) S: Jay Howell (26) | Second | 7 out |
| Tuesday, September 5 |
| » Defeated Dodgers (65-73), 3-2 | Astrodome (40-31) | 73-65 | |
| » W: Juan Agosto (4-5) L: Alejandro Pena (3-3) S: Larry Andersen (3) | Second | 6 out |
| Wednesday, September 6 |
| » Lost to Padres (74-65), 3-2 | Astrodome (40-32) | 73-66 | |
| » W: Calvin Schiraldi (4-6) L: Jim Deshaies (12-8) S: Mark Davis (37) | Third | 7 out |
| Thursday, September 7 |
| » Defeated Padres (74-66), 2-1 | Astrodome (41-32) | 74-66 | |
| » W: Jim Clancy (7-11) L: Bruce Hurst (13-10) S: Dave Smith (24) | Second | 7 out |
| Friday, September 8 |
| » Defeated Giants (81-60), 5-2 | Astrodome (42-32) | 75-66 | Won 2 |
| » W: Mark Portugal (4-1) L: Don Robinson (12-10) S: Danny Darwin (5) | Second | 6 out |
| Saturday, September 9 |
| » Defeated Giants (81-61), 4-1 | Astrodome (43-32) | 76-66 | Won 3 |
| » W: Mike Scott (19-8) L: Kelly Downs (3-6) | Second | 5 out |
| Sunday, September 10 |
| » Lost to Giants (82-61), 5-3 | Astrodome (43-33) | 76-67 | |
| » W: Bob Knepper (7-11) L: Rick Rhoden (1-6) S: Craig Lefferts (20) | Second | 6 out |
| Monday, September 11 |
| » Lost to Padres (77-67), 7-3 | San Diego/Jack Murphy Stadium (3-5) | 76-68 | Lost 2 |
| » W: Calvin Schiraldi (5-6) L: Jim Deshaies (12-9) | Third | 7 out |
| Tuesday, September 12 |
| » Lost to Padres (78-67), 9-0 | San Diego/Jack Murphy Stadium (3-6) | 76-69 | Lost 3 |
| » W: Bruce Hurst (14-10) L: Jim Clancy (7-12) | Third | 7 out |
| Wednesday, September 13 |
| » Defeated Dodgers (69-77), 3-1 | Dodger Stadium (3-5) | 77-69 | |
| » W: Mark Portugal (5-1) L: Orel Hershiser (14-13) S: Danny Darwin (6) | Third | 7 out |
| Thursday, September 14 |
| » Defeated Dodgers (69-78), 11-3 | Dodger Stadium (4-5) | 78-69 | Won 2 |
| » W: Mike Scott (20-8) L: John Wetteland (4-8) | Third | 7 out |
| Friday, September 15 |
| » Defeated Reds (70-78), 4-1 | Astrodome (44-33) | 79-69 | Won 3 |
| » W: Rick Rhoden (2-6) L: Jack Armstrong (2-2) S: Dave Smith (25) | Third | 6 out |
| Saturday, September 16 |
| » Defeated Reds (70-79), 3-1 | Astrodome (45-33) | 80-69 | Won 4 |
| » W: Jim Deshaies (13-9) L: Ron Robinson (4-3) | Third | 5½ out |
| Sunday, September 17 |
| » Defeated Reds (70-80), 1-0 | Astrodome (46-33) | 81-69 | Won 5 |
| » W: Mark Portugal (6-1) L: Tom Browning (15-12) | Second | 5 out |
| Tuesday, September 19 |
| » Lost to Braves (59-92), 3-0 | Atlanta-Fulton County Stadium (4-3) | 81-70 | |
| » W: Gary Eave (1-0) L: Mike Scott (20-9) S: Mike Stanton (5) | Third | 6 out |
| Wednesday, September 20 |
| » Defeated Braves (59-93), 7-6 | Atlanta-Fulton County Stadium (5-3) | 82-70 | |
| » W: Larry Andersen (4-4) L: Joe Boever (4-11) S: Brian Meyer (1) | Third | 6 out |
| Thursday, September 21 |
| » Lost to Braves (60-93), 3-0 | Atlanta-Fulton County Stadium (5-4) | 82-71 | |
| » W: Tommy Greene (1-1) L: Jim Deshaies (13-10) | Third | 7 out |
| Friday, September 22 |
| » Defeated Giants (89-65), 3-1 | Candlestick Park (2-5) | 83-71 | |
|