| Tuesday, April 4 |
| » Lost to White Sox (1-0), 9-2 | Anaheim Stadium (0-1) | 0-1 | |
| » W: Jerry Reuss (1-0) L: Mike Witt (0-1) S: Donn Pall (1) | Second | 1 out |
| Wednesday, April 5 |
| » Defeated White Sox (1-1), 6-2 | Anaheim Stadium (1-1) | 1-1 | |
| » W: Chuck Finley (1-0) L: Eric King (0-1) S: Greg Minton (1) | Third | 1 out |
| Thursday, April 6 |
| » Lost to White Sox (2-1), 3-2 | Anaheim Stadium (1-2) | 1-2 | |
| » W: Ken Patterson (1-0) L: Willie Fraser (0-1) S: Donn Pall (2) | Fourth | 2 out |
| Friday, April 7 |
| » Defeated Mariners (0-4), 2-1 | Anaheim Stadium (2-2) | 2-2 | |
| » W: Kirk McCaskill (1-0) L: Erik Hanson (0-1) S: Bryan Harvey (1) | Third | 1 out |
| Saturday, April 8 |
| » Lost to Mariners (1-4), 7-0 | Anaheim Stadium (2-3) | 2-3 | |
| » W: Mark Langston (1-1) L: Jim Abbott (0-1) | Fourth | 2 out |
| » Major-league debuts: Jim Abbott (Angels) |
| Sunday, April 9 |
| » Defeated Mariners (1-5), 13-5 | Anaheim Stadium (3-3) | 3-3 | |
| » W: Mike Witt (1-1) L: Steve Trout (0-1) | Third | 1½ out |
| Monday, April 10 |
| » Lost to Athletics (5-2), 4-0 | Anaheim Stadium (3-4) | 3-4 | |
| » W: Bob Welch (2-0) L: Chuck Finley (1-1) | Fifth | 2½ out |
| Tuesday, April 11 |
| » Defeated Athletics (5-3), 7-1 | Anaheim Stadium (4-4) | 4-4 | |
| » W: Bert Blyleven (1-0) L: Storm Davis (1-1) | Fifth | 2 out |
| Wednesday, April 12 |
| » Defeated Athletics (5-4), 5-0 | Anaheim Stadium (5-4) | 5-4 | Won 2 |
| » W: Kirk McCaskill (2-0) L: Curt Young (0-2) | Fourth | 2 out |
| Thursday, April 13 |
| » Lost to Athletics (6-4), 5-0 | Anaheim Stadium (5-5) | 5-5 | |
| » W: Mike Moore (1-1) L: Jim Abbott (0-2) | Sixth | 3 out |
| Friday, April 14 |
| » Lost to Mariners (4-6), 9-5 | Kingdome (0-1) | 5-6 | Lost 2 |
| » W: Mark Langston (2-1) L: Mike Witt (1-2) | Sixth | 4 out |
| Saturday, April 15 |
| » Defeated Mariners (4-7), 9-2 | Kingdome (1-1) | 6-6 | |
| » W: Chuck Finley (2-1) L: Jerry Reed (1-1) | Sixth | 4 out |
| » Major-league debuts: Kent Anderson (Angels) |
| Sunday, April 16 |
| » Defeated Mariners (4-8), 10-0 | Kingdome (2-1) | 7-6 | Won 2 |
| » W: Bert Blyleven (2-0) L: Mike Campbell (0-2) | Fifth | 4 out |
| Monday, April 17 |
| » Defeated White Sox (6-7), 3-0 | Comiskey Park I (1-0) | 8-6 | Won 3 |
| » W: Kirk McCaskill (3-0) L: Shawn Hillegas (0-1) S: Bryan Harvey (2) | Fourth | 3 out |
| Wednesday, April 19 |
| » Defeated White Sox (6-8), 7-2 | Comiskey Park I (2-0) | 9-6 | Won 4 |
| » W: Mike Witt (2-2) L: Bill Long (1-2) S: Greg Minton (2) | Third | 3½ out |
| Friday, April 21 |
| » Lost to Athletics (11-6), 10-6 | Oakland-Alameda County Stadium (0-1) | 9-7 | |
| » W: Bob Welch (3-1) L: Chuck Finley (2-2) S: Rick Honeycutt (1) | Fourth | 3½ out |
| Saturday, April 22 |
| » Lost to Athletics (12-6), 4-3 | Oakland-Alameda County Stadium (0-2) | 9-8 | Lost 2 |
| » W: Curt Young (1-3) L: Bert Blyleven (2-1) S: Dennis Eckersley (5) | Fifth | 3½ out |
| Sunday, April 23 |
| » Lost to Athletics (13-6), 2-0 | Oakland-Alameda County Stadium (0-3) | 9-9 | Lost 3 |
| » W: Mike Moore (2-1) L: Kirk McCaskill (3-1) S: Dennis Eckersley (6) | Fifth | 4½ out |
| Monday, April 24 |
| » Defeated Orioles (9-9), 3-2 | Anaheim Stadium (6-5) | 10-9 | |
| » W: Jim Abbott (1-2) L: Dave Schmidt (1-2) S: Bryan Harvey (3) | Fifth | 4 out |
| Tuesday, April 25 |
| » Lost to Orioles (10-9), 8-1 | Anaheim Stadium (6-6) | 10-10 | |
| » W: Jeff Ballard (4-0) L: Mike Witt (2-3) | Fifth | 5 out |
| » Major-league debuts: Chris Hoiles (Orioles) |
| Wednesday, April 26 |
| » Defeated Tigers (7-11), 1-0 | Anaheim Stadium (7-6) | 11-10 | |
| » W: Chuck Finley (3-2) L: Jack Morris (0-5) S: Bryan Harvey (4) | Fourth | 5 out |
| Thursday, April 27 |
| » Defeated Tigers (7-12), 10-3 | Anaheim Stadium (8-6) | 12-10 | Won 2 |
| » W: Bert Blyleven (3-1) L: Charles Hudson (0-1) | Fourth | 4½ out |
| » Major-league debuts: Ramon Pena (Tigers) |
| Friday, April 28 |
| » Defeated Blue Jays (9-14), 9-0 | Anaheim Stadium (9-6) | 13-10 | Won 3 |
| » W: Kirk McCaskill (4-1) L: Todd Stottlemyre (0-3) | Fourth | 4 out |
| Saturday, April 29 |
| » Defeated Blue Jays (9-15), 4-3 | Anaheim Stadium (10-6) | 14-10 | Won 4 |
| » W: Greg Minton (1-0) L: Duane Ward (1-3) | Fourth | 3½ out |
| Sunday, April 30 |
| » Defeated Blue Jays (9-16), 1-0 | Anaheim Stadium (11-6) | 15-10 | Won 5 |
| » W: Bob McClure (1-0) L: Tom Henke (1-3) | Fourth | 3½ out |
| Tuesday, May 2 |
| » Lost to Orioles (13-12), 4-3 | Memorial Stadium (0-1) | 15-11 | |
| » W: Gregg Olson (3-0) L: Willie Fraser (0-2) | Fourth | 3 out |
| Wednesday, May 3 |
| » Defeated Orioles (13-13), 2-0 | Memorial Stadium (1-1) | 16-11 | |
| » W: Rich Monteleone (1-0) L: Bob Milacki (1-2) | Fourth | 3 out |
| Thursday, May 4 |
| » Defeated Blue Jays (10-18), 3-2 | Exhibition Stadium (1-0) | 17-11 | Won 2 |
| » W: Bryan Harvey (1-0) L: Duane Ward (1-5) S: Greg Minton (3) | Fourth | 2 out |
| Friday, May 5 |
| » Defeated Blue Jays (10-19), 5-3 | Exhibition Stadium (2-0) | 18-11 | Won 3 |
| » W: Jim Abbott (2-2) L: John Cerutti (0-2) S: Bryan Harvey (5) | Fourth | 2 out |
| Saturday, May 6 |
| » Defeated Blue Jays (10-20), 5-4 | Exhibition Stadium (3-0) | 19-11 | Won 4 |
| » W: Bob McClure (2-0) L: Duane Ward (1-6) | Third | 1 out |
| Monday, May 8 |
| » Defeated Tigers (9-20), 9-2 | Tiger Stadium (1-0) | 20-11 | Won 5 |
| » W: Chuck Finley (4-2) L: Doyle Alexander (3-3) | Second | 1½ out |
| Tuesday, May 9 |
| » Defeated Tigers (9-21), 5-1 | Tiger Stadium (2-0) | 21-11 | Won 6 |
| » W: Bert Blyleven (4-1) L: Paul Gibson (1-2) | Second | 1 out |
| Wednesday, May 10 |
| » Lost to Tigers (10-21), 3-2 | Tiger Stadium (2-1) | 21-12 | |
| » W: Willie Hernandez (1-0) L: Bryan Harvey (1-1) | Second | 1½ out |
| Friday, May 12 |
| » Lost to Yankees (17-16), 5-2 | Anaheim Stadium (11-7) | 21-13 | Lost 2 |
| » W: Richard Dotson (1-0) L: Jim Abbott (2-3) S: Lee Guetterman (5) | Second | 2 out |
| Saturday, May 13 |
| » Defeated Yankees (17-17), 6-1 | Anaheim Stadium (12-7) | 22-13 | |
| » W: Mike Witt (3-3) L: Tommy John (2-6) | Second | 2 out |
| Sunday, May 14 |
| » Defeated Yankees (17-18), 5-0 | Anaheim Stadium (13-7) | 23-13 | Won 2 |
| » W: Chuck Finley (5-2) L: Andy Hawkins (3-5) S: Greg Minton (4) | Second | 1 out |
| Monday, May 15 |
| » Defeated Yankees (17-19), 4-3 | Anaheim Stadium (14-7) | 24-13 | Won 3 |
| » W: Willie Fraser (1-2) L: Lance McCullers (1-1) | Second | 1 out |
| Tuesday, May 16 |
| » Defeated Red Sox (17-18), 7-2 | Anaheim Stadium (15-7) | 25-13 | Won 4 |
| » W: Kirk McCaskill (5-1) L: Mike Smithson (1-3) | First | -- |
| Wednesday, May 17 |
| » Defeated Red Sox (17-19), 5-0 | Anaheim Stadium (16-7) | 26-13 | Won 5 |
| » W: Jim Abbott (3-3) L: Roger Clemens (5-2) | First | -- |
| Thursday, May 18 |
| » Lost to Red Sox (18-19), 5-2 | Anaheim Stadium (16-8) | 26-14 | |
| » W: John Dopson (5-2) L: Mike Witt (3-4) S: Rob Murphy (1) | Second | 1 out |
| Friday, May 19 |
| » Defeated Brewers (16-23), 3-1 | Anaheim Stadium (17-8) | 27-14 | |
| » W: Chuck Finley (6-2) L: Bryan Clutterbuck (1-1) | First | -- |
| Saturday, May 20 |
| » Lost to Brewers (17-23), 5-3 | Anaheim Stadium (17-9) | 27-15 | |
| » W: Don August (3-5) L: Bert Blyleven (4-2) S: Dan Plesac (8) | Second | 1 out |
| Sunday, May 21 |
| » Defeated Brewers (17-24), 12-9 | Anaheim Stadium (18-9) | 28-15 | |
| » W: Dan Petry (1-0) L: Bill Wegman (2-6) | Second | 1 out |
| Wednesday, May 24 |
| » Defeated Yankees (20-23), 11-4 | Yankee Stadium (1-0) | 29-15 | Won 2 |
| » W: Jim Abbott (4-3) L: Richard Dotson (1-2) S: Greg Minton (5) | Second | ½ out |
| Thursday, May 25 |
| » Lost to Yankees (21-23), 8-6 | Yankee Stadium (1-1) | 29-16 | |
| » W: Dale Mohorcic (1-1) L: Willie Fraser (1-3) S: Dave Righetti (7) | Second | ½ out |
| Friday, May 26 |
| » Defeated Red Sox (22-22), 5-0 | Fenway Park (1-0) | 30-16 | |
| » W: Chuck Finley (7-2) L: Roger Clemens (5-4) | Second | ½ out |
| Sunday, May 28 |
| » Defeated Red Sox (22-23), 3-0 | Fenway Park (2-0) | 31-16 | Won 2 |
| » W: Kirk McCaskill (6-1) L: John Dopson (5-3) | Second | 1 out |
| Monday, May 29 |
| » Defeated Brewers (21-27), 12-3 | County Stadium (1-0) | 32-16 | Won 3 |
| » W: Bert Blyleven (5-2) L: Mike Birkbeck (0-4) | First | -- |
| Tuesday, May 30 |
| » Defeated Brewers (21-28), 3-2 | County Stadium (2-0) | 33-16 | Won 4 |
| » W: Jim Abbott (5-3) L: Bryan Clutterbuck (2-2) S: Bob McClure (1) | First | -- |
| Wednesday, May 31 |
| » Lost to Brewers (22-28), 4-1 | County Stadium (2-1) | 33-17 | |
| » W: Don August (4-6) L: Mike Witt (3-5) S: Dan Plesac (11) | First | -- |
| Friday, June 2 |
| » Lost to Royals (31-21), 4-0 | Anaheim Stadium (18-10) | 33-18 | Lost 2 |
| » W: Mark Gubicza (5-4) L: Chuck Finley (7-3) | First | -- |
| Saturday, June 3 |
| » Defeated Royals (31-22), 4-3 | Anaheim Stadium (19-10) | 34-18 | |
| » W: Kirk McCaskill (7-1) L: Charlie Leibrandt (3-6) S: Bob McClure (2) | First | -- |
| Sunday, June 4 |
| » Defeated Royals (31-23), 5-1 | Anaheim Stadium (20-10) | 35-18 | Won 2 |
| » W: Bert Blyleven (6-2) L: Kevin Appier (0-1) | First | -- |
| Monday, June 5 |
| » Lost to Indians (27-28), 7-3 | Anaheim Stadium (20-11) | 35-19 | |
| » W: Bud Black (5-6) L: Mike Witt (3-6) | First | -- |
| Tuesday, June 6 |
| » Defeated Indians (27-29), 2-1 | Anaheim Stadium (21-11) | 36-19 | |
| » W: Dan Petry (2-0) L: Rich Yett (4-4) S: Bryan Harvey (6) | First | -- |
| Wednesday, June 7 |
| » Lost to Indians (28-29), 1-0 | Anaheim Stadium (21-12) | 36-20 | |
| » W: Greg Swindell (7-1) L: Chuck Finley (7-4) | Second | 1 out |
| Friday, June 9 |
| » Lost to Royals (34-24), 6-1 | Royals Stadium (0-1) | 36-21 | Lost 2 |
| » W: Charlie Leibrandt (4-6) L: Kirk McCaskill (7-2) | Second | 1 out |
| Saturday, June 10 |
| » Lost to Royals (35-24), 5-4 | Royals Stadium (0-2) | 36-22 | Lost 3 |
| » W: Tom Gordon (7-2) L: Greg Minton (1-1) S: Steve Farr (12) | Second | 2 out |
| Sunday, June 11 |
| » Lost to Royals (36-24), 5-3 | Royals Stadium (0-3) | 36-23 | Lost 4 |
| » W: Terry Leach (1-0) L: Jim Abbott (5-4) S: Steve Farr (13) | Second | 3 out |
| Monday, June 12 |
| » Lost to Rangers (34-27), 4-0 | Arlington Stadium (0-1) | 36-24 | Lost 5 |
| » W: Mike Jeffcoat (2-0) L: Mike Witt (3-7) | Third | 3 out |
| Wednesday, June 14 |
| » Lost to Rangers (35-27), 5-1 | Arlington Stadium (0-2) | 36-25 | Lost 6 |
| » W: Nolan Ryan (8-3) L: Chuck Finley (7-5) S: Jeff Russell (15) | Third | 4 out |
| » Lost to Rangers (36-27), 6-3 | Arlington Stadium (0-3) | 36-26 | Lost 7 |
| » W: Charlie Hough (4-6) L: Kirk McCaskill (7-3) S: Jeff Russell (16) | Third | 4 out |
| Friday, June 16 |
| » Defeated Tigers (25-39), 9-4 | Tiger Stadium (3-1) | 37-26 | |
| » W: Bert Blyleven (7-2) L: Mike Schwabe (1-2) S: Bryan Harvey (7) | Third | 3½ out |
| Saturday, June 17 |
| » Defeated Tigers (25-40), 6-3 | Tiger Stadium (4-1) | 38-26 | Won 2 |
| » W: Jim Abbott (6-4) L: Doyle Alexander (4-7) S: Bob McClure (3) | Second | 2½ out |
| Sunday, June 18 |
| » Defeated Tigers (25-41), 3-1 | Tiger Stadium (5-1) | 39-26 | Won 3 |
| » W: Mike Witt (4-7) L: David Palmer (0-2) S: Bryan Harvey (8) | Second | 1½ out |
| Monday, June 19 |
| » Lost to Blue Jays (32-36), 8-1 | Anaheim Stadium (21-13) | 39-27 | |
| » W: Dave Stieb (7-3) L: Chuck Finley (7-6) | Second | 1½ out |
| Tuesday, June 20 |
| » Lost to Blue Jays (33-36), 6-2 | Anaheim Stadium (21-14) | 39-28 | Lost 2 |
| » W: Jimmy Key (7-6) L: Kirk McCaskill (7-4) | Third | 2½ out |
| Wednesday, June 21 |
| » Lost to Blue Jays (34-36), 6-1 | Anaheim Stadium (21-15) | 39-29 | Lost 3 |
| » W: Tom Henke (6-3) L: Greg Minton (1-2) | Third | 3½ out |
| Thursday, June 22 |
| » Lost to Orioles (41-28), 6-5 | Anaheim Stadium (21-16) | 39-30 | Lost 4 |
| » W: Mark Williamson (5-2) L: Willie Fraser (1-4) S: Gregg Olson (11) | Third | 3½ out |
| Friday, June 23 |
| » Defeated Orioles (41-29), 5-1 | Anaheim Stadium (22-16) | 40-30 | |
| » W: Mike Witt (5-7) L: Dave Schmidt (7-6) | Third | 2½ out |
| Saturday, June 24 |
| » Defeated Orioles (41-30), 8-3 | Anaheim Stadium (23-16) | 41-30 | Won 2 |
| » W: Chuck Finley (8-6) L: Bob Milacki (4-7) | Third | 2½ out |
| Sunday, June 25 |
| » Defeated Orioles (41-31), 7-6 | Anaheim Stadium (24-16) | 42-30 | Won 3 |
| » W: Kirk McCaskill (8-4) L: Jeff Ballard (9-3) S: Bryan Harvey (9) | Second | 2½ out |
| Tuesday, June 27 |
| » Defeated Indians (35-40), 2-1 | Cleveland Stadium (1-0) | 43-30 | Won 4 |
| » W: Rich Monteleone (2-0) L: Neil Allen (0-1) S: Bryan Harvey (10) | Second | 2 out |
| Wednesday, June 28 |
| » Lost to Indians (36-40), 2-1 | Cleveland Stadium (1-1) | 43-31 | |
| » W: Scott Bailes (3-3) L: Jim Abbott (6-5) S: Doug Jones (18) | Second | 2 out |
| Thursday, June 29 |
| » Defeated Twins (40-38), 10-3 | Hubert H. Humphrey Metrodome (1-0) | 44-31 | |
| » W: Mike Witt (6-7) L: Mike Dyer (0-1) | Second | 1½ out |
| » Major-league debuts: Mike Dyer (Twins) |
| Friday, June 30 |
| » Defeated Twins (40-39), 7-2 | Hubert H. Humphrey Metrodome (2-0) | 45-31 | Won 2 |
| » W: Chuck Finley (9-6) L: Allan Anderson (9-5) | Second | 1½ out |
| Saturday, July 1 |
| » Defeated Twins (40-40), 6-1 | Hubert H. Humphrey Metrodome (3-0) | 46-31 | Won 3 |
| » W: Kirk McCaskill (9-4) L: Shane Rawley (4-7) | Second | 1½ out |
| Sunday, July 2 |
| » Lost to Twins (41-40), 2-1 | Hubert H. Humphrey Metrodome (3-1) | 46-32 | |
| » W: Frank Viola (7-8) L: Rich Monteleone (2-1) | Second | 1½ out |
| Monday, July 3 |
| » Defeated Rangers (44-36), 5-2 | Anaheim Stadium (25-16) | 47-32 | |
| » W: Jim Abbott (7-5) L: Mike Jeffcoat (4-2) S: Bryan Harvey (11) | Second | 1½ out |
| Tuesday, July 4 |
| » Defeated Rangers (44-37), 5-2 | Anaheim Stadium (26-16) | 48-32 | Won 2 |
| » W: Willie Fraser (2-4) L: Kevin Brown (7-5) | Second | 1½ out |
| Wednesday, July 5 |
| » Defeated Rangers (44-38), 2-1 | Anaheim Stadium (27-16) | 49-32 | Won 3 |
| » W: Chuck Finley (10-6) L: Charlie Hough (5-9) | First | -- |
| Thursday, July 6 |
| » Lost to Rangers (45-38), 3-0 | Anaheim Stadium (27-17) | 49-33 | |
| » W: Nolan Ryan (10-4) L: Kirk McCaskill (9-5) | Second | 1½ out |
| Friday, July 7 |
| » Defeated Twins (41-44), 5-2 | Anaheim Stadium (28-17) | 50-33 | |
| » W: Bert Blyleven (8-2) L: Frank Viola (7-9) | First | -- |
| Saturday, July 8 |
| » Defeated Twins (41-45), 4-1 | Anaheim Stadium (29-17) | 51-33 | Won 2 |
| » W: Jim Abbott (8-5) L: Roy Smith (4-4) S: Bryan Harvey (12) | First | -- |
| Sunday, July 9 |
| » Defeated Twins (41-46), 9-3 | Anaheim Stadium (30-17) | 52-33 | Won 3 |
| » W: Mike Witt (7-7) L: Allan Anderson (9-7) | First | -- |
| Thursday, July 13 |
| » Defeated Orioles (48-38), 13-5 | Memorial Stadium (2-1) | 53-33 | Won 4 |
| » W: Bert Blyleven (9-2) L: Mark Thurmond (2-3) | First | -- |
| Friday, July 14 |
| » Lost to Orioles (49-38), 6-4 | Memorial Stadium (2-2) | 53-34 | |
| » W: Brian Holton (4-5) L: Kirk McCaskill (9-6) S: Gregg Olson (15) | First | -- |
| Saturday, July 15 |
| » Lost to Orioles (50-38), 11-9 | Memorial Stadium (2-3) | 53-35 | Lost 2 |
| » W: Mark Williamson (6-2) L: Bryan Harvey (1-2) | First | -- |
| Sunday, July 16 |
| » Lost to Orioles (51-38), 3-2 | Memorial Stadium (2-4) | 53-36 | Lost 3 |
| » W: Mike Smith (2-0) L: Willie Fraser (2-5) | First | -- |
| Monday, July 17 |
| » Lost to Blue Jays (45-47), 6-4 | Skydome (0-1) | 53-37 | Lost 4 |
| » W: David Wells (3-4) L: Jim Abbott (8-6) S: Tom Henke (6) | First | -- |
| » Lost to Blue Jays (46-47), 5-4 | Skydome (0-2) | 53-38 | Lost 5 |
| » W: David Wells (4-4) L: Bob McClure (2-1) S: Tom Henke (7) | First | -- |
| Tuesday, July 18 |
| » Defeated Blue Jays (46-48), 1-0 | Skydome (1-2) | 54-38 | |
| » W: Bert Blyleven (10-2) L: Jimmy Key (7-10) | First | -- |
| Former Angel Donnie Moore dies in Anaheim, CA at the age of 36. |
| Thursday, July 20 |
| » Defeated Tigers (33-59), 4-3 | Anaheim Stadium (31-17) | 55-38 | Won 2 |
| » W: Chuck Finley (11-6) L: Mike Henneman (6-3) | First | -- |
| Friday, July 21 |
| » Defeated Tigers (33-60), 8-7 | Anaheim Stadium (32-17) | 56-38 | Won 3 |
| » W: Bryan Harvey (2-2) L: Dave Beard (0-2) | First | -- |
| Saturday, July 22 |
| » Defeated Tigers (33-61), 5-4 | Anaheim Stadium (33-17) | 57-38 | Won 4 |
| » W: Dan Petry (3-0) L: Charles Hudson (1-5) | First | -- |
| Sunday, July 23 |
| » Defeated Tigers (33-62), 5-4 | Anaheim Stadium (34-17) | 58-38 | Won 5 |
| » W: Bob McClure (3-1) L: Mike Henneman (6-4) | First | -- |
| Monday, July 24 |
| » Defeated Athletics (59-40), 5-4 | Oakland-Alameda County Stadium (1-3) | 59-38 | Won 6 |
| » W: Willie Fraser (3-5) L: Gene Nelson (2-5) S: Bryan Harvey (13) | First | -- |
| Tuesday, July 25 |
| » Defeated Athletics (59-41), 4-0 | Oakland-Alameda County Stadium (2-3) | 60-38 | Won 7 |
| » W: Chuck Finley (12-6) L: Dave Stewart (14-6) S: Greg Minton (6) | First | -- |
| Wednesday, July 26 |
| » Lost to Athletics (60-41), 9-5 | Oakland-Alameda County Stadium (2-4) | 60-39 | |
| » W: Matt Young (1-3) L: Mike Witt (7-8) | First | -- |
| Thursday, July 27 |
| » Defeated White Sox (43-58), 8-5 | Anaheim Stadium (35-17) | 61-39 | |
| » W: Jim Abbott (9-6) L: Melido Perez (7-11) S: Bryan Harvey (14) | First | -- |
| Friday, July 28 |
| » Defeated White Sox (43-59), 6-5 | Anaheim Stadium (36-17) | 62-39 | Won 2 |
| » W: Bryan Harvey (3-2) L: Donn Pall (3-2) | First | -- |
| Saturday, July 29 |
| » Defeated White Sox (43-60), 2-1 | Anaheim Stadium (37-17) | 63-39 | Won 3 |
| » W: Kirk McCaskill (10-6) L: Steve Rosenberg (3-7) S: Bryan Harvey (15) | First | -- |
| Sunday, July 30 |
| » Lost to White Sox (44-60), 3-2 | Anaheim Stadium (37-18) | 63-40 | |
| » W: Jerry Reuss (8-5) L: Chuck Finley (12-7) S: Bobby Thigpen (22) | First | -- |
| Monday, July 31 |
| » Lost to Mariners (50-54), 6-5 | Kingdome (2-2) | 63-41 | Lost 2 |
| » W: Keith Comstock (1-0) L: Bryan Harvey (3-3) S: Mike Schooler (21) | First | -- |
| Tuesday, August 1 |
| » Lost to Mariners (51-54), 8-1 | Kingdome (2-3) | 63-42 | Lost 3 |
| » W: Mike Dunne (3-6) L: Jim Abbott (9-7) | Second | ½ out |
| Wednesday, August 2 |
| » Defeated Mariners (51-55), 7-0 | Kingdome (3-3) | 64-42 | |
| » W: Bert Blyleven (11-2) L: Jerry Reed (3-6) | Second | ½ out |
| Thursday, August 3 |
| » Defeated Mariners (51-56), 6-0 | Kingdome (4-3) | 65-42 | Won 2 |
| » W: Kirk McCaskill (11-6) L: Randy Johnson (5-7) | First | -- |
| Friday, August 4 |
| » Defeated Brewers (52-56), 6-2 | County Stadium (3-1) | 66-42 | Won 3 |
| » W: Chuck Finley (13-7) L: Jerry Reuss (8-6) S: Willie Fraser (1) | First | -- |
| Saturday, August 5 |
| » Lost to Brewers (53-56), 5-2 | County Stadium (3-2) | 66-43 | |
| » W: Teddy Higuera (7-4) L: Mike Witt (7-9) | First | -- |
| Sunday, August 6 |
| » Defeated Brewers (53-57), 6-0 | County Stadium (4-2) | 67-43 | |
| » W: Jim Abbott (10-7) L: Jaime Navarro (3-4) | First | -- |
| Tuesday, August 8 |
| » Lost to Mariners (54-58), 6-4 | Anaheim Stadium (37-19) | 67-44 | |
| » W: Jerry Reed (4-6) L: Greg Minton (1-3) S: Mike Schooler (22) | First | -- |
| Wednesday, August 9 |
| » Defeated Mariners (54-59), 4-1 | Anaheim Stadium (38-19) | 68-44 | |
| » W: Kirk McCaskill (12-6) L: Brian Holman (5-7) S: Bryan Harvey (16) | First | -- |
| Thursday, August 10 |
| » Lost to Mariners (55-59), 3-2 | Anaheim Stadium (38-20) | 68-45 | |
| » W: Mike Jackson (4-5) L: Chuck Finley (13-8) S: Mike Schooler (23) | First | -- |
| Friday, August 11 |
| » Lost to Athletics (70-46), 5-0 | Anaheim Stadium (38-21) | 68-46 | Lost 2 |
| » W: Mike Moore (15-6) L: Mike Witt (7-10) | Second | 1 out |
| Saturday, August 12 |
| » Lost to Athletics (71-46), 8-3 | Anaheim Stadium (38-22) | 68-47 | Lost 3 |
| » W: Bob Welch (12-7) L: Jim Abbott (10-8) S: Todd Burns (8) | Second | 2 out |
| » Major-league debuts: Bobby Rose (Angels) |
| Sunday, August 13 |
| » Defeated Athletics (71-47), 4-3 | Anaheim Stadium (39-22) | 69-47 | |
| » W: Bert Blyleven (12-2) L: Dave Stewart (16-7) S: Bryan Harvey (17) | Second | 1 out |
| Monday, August 14 |
| » Lost to Twins (59-59), 6-3 | Anaheim Stadium (39-23) | 69-48 | |
| » W: Allan Anderson (14-9) L: Kirk McCaskill (12-7) S: Jeff Reardon (22) | Second | 1½ out |
| Tuesday, August 15 |
| » Defeated Twins (59-60), 3-2 | Anaheim Stadium (40-23) | 70-48 | |
| » W: Chuck Finley (14-8) L: Mike Dyer (1-3) S: Bryan Harvey (18) | Second | 1½ out |
| Wednesday, August 16 |
| » Defeated Twins (59-61), 7-3 | Anaheim Stadium (41-23) | 71-48 | Won 2 |
| » W: Mike Witt (8-10) L: Shane Rawley (5-11) | Second | ½ out |
| Friday, August 18 |
| » Defeated Indians (58-64), 6-5 | Anaheim Stadium (42-23) | 72-48 | Won 3 |
| » W: Greg Minton (2-3) L: Steve Olin (1-1) S: Bryan Harvey (19) | First | -- |
| Saturday, August 19 |
| » Defeated Indians (58-65), 7-4 | Anaheim Stadium (43-23) | 73-48 | Won 4 |
| » W: Bert Blyleven (13-2) L: Rod Nichols (3-3) S: Greg Minton (7) | First | -- |
| Sunday, August 20 |
| » Defeated Indians (58-66), 1-0 | Anaheim Stadium (44-23) | 74-48 | Won 5 |
| » W: Kirk McCaskill (13-7) L: Bud Black (9-10) | First | -- |
| » Major-league debuts: John Orton (Angels) |
| Monday, August 21 |
| » Lost to Royals (71-53), 4-2 | Royals Stadium (0-4) | 74-49 | |
| » W: Bret Saberhagen (15-5) L: Willie Fraser (3-6) S: Rick Luecken (1) | Second | 1 out |
| Tuesday, August 22 |
| » Lost to Royals (72-53), 4-2 | Royals Stadium (0-5) | 74-50 | Lost 2 |
| » W: Terry Leach (5-3) L: Mike Witt (8-11) S: Jeff Montgomery (12) | Second | 2 out |
| Wednesday, August 23 |
| » Lost to Royals (73-53), 6-4 | Royals Stadium (0-6) | 74-51 | Lost 3 |
| » W: Tom Gordon (16-4) L: Jim Abbott (10-9) S: Jeff Montgomery (13) | Second | 3 out |
| Thursday, August 24 |
| » Defeated Royals (73-54), 5-0 | Royals Stadium (1-6) | 75-51 | |
| » W: Bert Blyleven (14-2) L: Luis Aquino (6-8) | Second | 2 out |
| Friday, August 25 |
| » Defeated Rangers (66-60), 4-1 | Arlington Stadium (1-3) | 76-51 | Won 2 |
| » W: Kirk McCaskill (14-7) L: Bobby Witt (10-11) S: Greg Minton (8) | Second | 1 out |
| Saturday, August 26 |
| » Lost to Rangers (67-60), 3-2 | Arlington Stadium (1-4) | 76-52 | |
| » W: Charlie Hough (9-12) L: Terry Clark (0-1) S: Jeff Russell (29) | Second | 1 out |
| Sunday, August 27 |
| » Defeated Rangers (67-61), 5-4 | Arlington Stadium (2-4) | 77-52 | |
| » W: Bob McClure (4-1) L: Nolan Ryan (14-9) | Second | 1 out |
| Tuesday, August 29 |
| » Lost to Red Sox (66-65), 8-4 | Fenway Park (2-1) | 77-53 | |
| » W: Dennis Lamp (3-1) L: Bert Blyleven (14-3) | Second | 3 out |
| » Lost to Red Sox (67-65), 13-5 | Fenway Park (2-2) | 77-54 | Lost 2 |
| » W: Bob Stanley (5-2) L: Dan Petry (3-1) | Second | 3 out |
| Wednesday, August 30 |
| » Defeated Red Sox (67-66), 4-0 | Fenway Park (3-2) | 78-54 | |
| » W: Jim Abbott (11-9) L: John Dopson (9-6) | Second | 2 out |
| Thursday, August 31 |
| » Lost to Red Sox (68-66), 5-2 | Fenway Park (3-3) | 78-55 | |
| » W: Roger Clemens (14-9) L: Kirk McCaskill (14-8) | Second | 2½ out |
| Friday, September 1 |
| » Lost to Yankees (60-76), 11-5 | Yankee Stadium (1-2) | 78-56 | Lost 2 |
| » W: Walt Terrell (8-17) L: Terry Clark (0-2) S: Lee Guetterman (11) | Third | 2½ out |
| » Major-league debuts: Mike Blowers (Yankees) Mike Fetters (Angels) |
| Saturday, September 2 |
| » Lost to Yankees (61-76), 2-1 | Yankee Stadium (1-3) | 78-57 | Lost 3 |
| » W: Greg Cadaret (5-4) L: Mike Witt (8-12) | Third | 3½ out |
| Sunday, September 3 |
| » Lost to Yankees (62-76), 5-2 | Yankee Stadium (1-4) | 78-58 | Lost 4 |
| » W: Andy Hawkins (14-13) L: Bert Blyleven (14-4) S: Lance McCullers (3) | Third | 4½ out |
| Monday, September 4 |
| » Lost to Yankees (63-76), 2-1 | Yankee Stadium (1-5) | 78-59 | Lost 5 |
| » W: Clay Parker (4-4) L: Jim Abbott (11-10) S: Dave Righetti (21) | Third | 4½ out |
| Tuesday, September 5 |
| » Defeated Brewers (68-72), 8-4 | Anaheim Stadium (45-23) | 79-59 | |
| » W: Kirk McCaskill (15-8) L: Mark Knudson (5-5) S: Willie Fraser (2) | Third | 4½ out |
| Wednesday, September 6 |
| » Lost to Brewers (69-72), 7-4 | Anaheim Stadium (45-24) | 79-60 | |
| » W: Chris Bosio (15-9) L: Dan Petry (3-2) S: Dan Plesac (29) | Third | 5½ out |
| Thursday, September 7 |
| » Lost to Brewers (70-72), 7-1 | Anaheim Stadium (45-25) | 79-61 | Lost 2 |
| » W: Tom Filer (6-3) L: Mike Witt (8-13) | Third | 6 out |
| Friday, September 8 |
| » Defeated Red Sox (70-71), 2-1 | Anaheim Stadium (46-25) | 80-61 | |
| » W: Bert Blyleven (15-4) L: Mike Boddicker (12-10) S: Bryan Harvey (20) | Third | 5 out |
| Saturday, September 9 |
| » Defeated Red Sox (70-72), 8-5 | Anaheim Stadium (47-25) | 81-61 | Won 2 |
| » W: Willie Fraser (4-6) L: Rob Murphy (4-7) S: Bryan Harvey (21) | Third | 5 out |
| Sunday, September 10 |
| » Defeated Red Sox (70-73), 2-1 | Anaheim Stadium (48-25) | 82-61 | Won 3 |
| » W: Bob McClure (5-1) L: Dennis Lamp (4-2) | Third | 5 out |
| Tuesday, September 12 |
| » Defeated Yankees (67-79), 7-6 | Anaheim Stadium (49-25) | 83-61 | Won 4 |
| » W: Bob McClure (6-1) L: Chuck Cary (3-4) | Third | 4 out |
| Wednesday, September 13 |
| » Defeated Yankees (67-80), 4-3 | Anaheim Stadium (50-25) | 84-61 | Won 5 |
| » W: Greg Minton (3-3) L: Dave Righetti (2-6) | Third | 4 out |
| Friday, September 15 |
| » Lost to White Sox (62-84), 3-1 | Comiskey Park I (2-1) | 84-62 | |
| » W: Melido Perez (10-13) L: Jim Abbott (11-11) | Second | 3½ out |
| » Defeated White Sox (62-85), 2-1 | Comiskey Park I (3-1) | 85-62 | |
| » W: Chuck Finley (15-8) L: Richard Dotson (4-10) S: Bryan Harvey (22) | Second | 3½ out |
| Saturday, September 16 |
| » Lost to White Sox (63-85), 2-1 | Comiskey Park I (3-2) | 85-63 | |
| » W: Shawn Hillegas (7-10) L: Kirk McCaskill (15-9) S: Bobby Thigpen (31) | Second | 3½ out |
| Sunday, September 17 |
| » Defeated White Sox (63-86), 6-3 | Comiskey Park I (4-2) | 86-63 | |
| » W: Mike Witt (9-13) L: Eric King (8-10) S: Bryan Harvey (23) | Second | 2½ out |
| Monday, September 18 |
| » Defeated Twins (76-74), 6-3 | Hubert H. Humphrey Metrodome (4-1) | 87-63 | Won 2 |
| » W: Bert Blyleven (16-4) L: David West (3-4) | Second | 2½ out |
| Tuesday, September 19 |
| » Defeated Twins (76-75), 7-3 | Hubert H. Humphrey Metrodome (5-1) | 88-63 | Won 3 |
| » W: Chuck Finley (16-8) L: Kevin Tapani (2-1) S: Bryan Harvey (24) | Second | 2½ out |
| Wednesday, September 20 |
| » Defeated Twins (76-76), 9-1 | Hubert H. Humphrey Metrodome (6-1) | 89-63 | Won 4 |
| » W: Jim Abbott (12-11) L: Mark Guthrie (2-2) | Second | 2½ out |
| Thursday, September 21 |
| » Lost to Indians (68-85), 5-4 | Cleveland Stadium (1-2) | 89-64 | |
| » W: Scott Bailes (5-9) L: Rich Monteleone (2-2) | Second | 3½ out |
| Saturday, September 23 |
|