| Monday, March 14 |
| Former White Sox Zeb Terry dies in Los Angeles, CA at the age of 97. |
| Monday, March 21 |
| Former White Sox Edd Roush dies in Bradenton, FL at the age of 95. |
| Tuesday, March 29 |
| Former White Sox Ted Kluszewski dies in Cincinnati, OH at the age of 64. |
| Monday, April 4 |
| » Defeated Angels (0-1), 8-5 | Comiskey Park I (1-0) | 1-0 | |
| » W: Ricky Horton (1-0) L: Mike Witt (0-1) S: Bobby Thigpen (1) | First | -- |
| Wednesday, April 6 |
| » Lost to Angels (1-1), 4-2 | Comiskey Park I (1-1) | 1-1 | |
| » W: Donnie Moore (1-0) L: Bobby Thigpen (0-1) | Second | ½ out |
| Thursday, April 7 |
| » Defeated Angels (1-2), 2-1 | Comiskey Park I (2-1) | 2-1 | |
| » W: Dave LaPoint (1-0) L: Chuck Finley (0-1) S: Bill Long (1) | First | -- |
| Friday, April 8 |
| » Defeated Mariners (1-3), 3-2 | Comiskey Park I (3-1) | 3-1 | Won 2 |
| » W: John Davis (1-0) L: Bill Wilkinson (0-1) | First | -- |
| Saturday, April 9 |
| » Lost to Mariners (2-3), 3-2 | Comiskey Park I (3-2) | 3-2 | |
| » W: Jerry Reed (1-0) L: Ricky Horton (1-1) | Second | 1 out |
| Sunday, April 10 |
| » Lost to Mariners (3-3), 7-4 | Comiskey Park I (3-3) | 3-3 | Lost 2 |
| » W: Mike Moore (1-1) L: Jerry Reuss (0-1) | Second | 1 out |
| Tuesday, April 12 |
| » Lost to Angels (3-4), 15-6 | Anaheim Stadium (0-1) | 3-4 | Lost 3 |
| » W: Dan Petry (1-0) L: Jack McDowell (0-1) | Third | 1 out |
| Wednesday, April 13 |
| » Lost to Angels (4-4), 5-2 | Anaheim Stadium (0-2) | 3-5 | Lost 4 |
| » W: Chuck Finley (1-1) L: Dave LaPoint (1-1) S: De Wayne Buice (2) | Fourth | 2 out |
| Friday, April 15 |
| » Defeated Athletics (6-4), 11-3 | Oakland-Alameda County Stadium (1-0) | 4-5 | |
| » W: Ricky Horton (2-1) L: Bob Welch (1-2) | Fourth | 2 out |
| Saturday, April 16 |
| » Defeated Athletics (6-5), 5-1 | Oakland-Alameda County Stadium (2-0) | 5-5 | Won 2 |
| » W: Melido Perez (1-0) L: Storm Davis (1-1) S: Bobby Thigpen (2) | Third | 1 out |
| Sunday, April 17 |
| » Defeated Athletics (6-6), 7-6 | Oakland-Alameda County Stadium (3-0) | 6-5 | Won 3 |
| » W: Jack McDowell (1-1) L: Steve Ontiveros (1-1) S: Bobby Thigpen (3) | First | -- |
| Monday, April 18 |
| » Defeated Mariners (5-8), 4-0 | Kingdome (1-0) | 7-5 | Won 4 |
| » W: Dave LaPoint (2-1) L: Mike Campbell (0-2) | First | -- |
| Tuesday, April 19 |
| » Defeated Mariners (5-9), 7-2 | Kingdome (2-0) | 8-5 | Won 5 |
| » W: Jerry Reuss (1-1) L: Mark Langston (0-2) | First | -- |
| Wednesday, April 20 |
| » Lost to Mariners (6-9), 5-4 | Kingdome (2-1) | 8-6 | |
| » W: Mike Moore (2-1) L: Ricky Horton (2-2) | Second | ½ out |
| Thursday, April 21 |
| » Lost to Athletics (10-6), 6-3 | Comiskey Park I (3-4) | 8-7 | Lost 2 |
| » W: Gene Nelson (2-2) L: Bill Long (0-1) S: Dennis Eckersley (7) | Second | 1½ out |
| Friday, April 22 |
| » Defeated Athletics (10-7), 7-5 | Comiskey Park I (4-4) | 9-7 | |
| » W: John Pawlowski (1-0) L: Eric Plunk (1-1) | Second | ½ out |
| Saturday, April 23 |
| » Lost to Athletics (11-7), 3-2 | Comiskey Park I (4-5) | 9-8 | |
| » W: Dave Stewart (5-0) L: John Davis (1-1) | Second | 1½ out |
| Sunday, April 24 |
| » Lost to Athletics (12-7), 5-3 | Comiskey Park I (4-6) | 9-9 | Lost 2 |
| » W: Bob Welch (2-2) L: Ricky Horton (2-3) S: Dennis Eckersley (8) | Third | 2½ out |
| Wednesday, April 27 |
| Former White Sox Tommy Thomas dies in Dallastown, PA at the age of 89. |
| Thursday, April 28 |
| » Defeated Red Sox (12-6), 6-0 | Comiskey Park I (5-6) | 10-9 | |
| » W: Dave LaPoint (3-1) L: Oil Can Boyd (2-1) | Third | 3½ out |
| Friday, April 29 |
| » Lost to Orioles (1-21), 9-0 | Comiskey Park I (5-7) | 10-10 | |
| » W: Mark Williamson (1-0) L: Jack McDowell (1-2) S: Dave Schmidt (1) | Third | 4 out |
| Saturday, April 30 |
| » Defeated Orioles (1-22), 4-1 | Comiskey Park I (6-7) | 11-10 | |
| » W: Ricky Horton (3-3) L: Mark Thurmond (0-5) S: Bobby Thigpen (4) | Third | 4 out |
| Sunday, May 1 |
| » Defeated Orioles (1-23), 7-3 | Comiskey Park I (7-7) | 12-10 | Won 2 |
| » W: Melido Perez (2-0) L: Mike Morgan (0-5) S: John Davis (1) | Second | 4 out |
| Monday, May 2 |
| » Lost to Yankees (17-8), 6-4 | Comiskey Park I (7-8) | 12-11 | |
| » W: Tim Stoddard (2-1) L: Bobby Thigpen (0-2) S: John Candelaria (1) | Third | 5 out |
| Tuesday, May 3 |
| » Lost to Yankees (18-8), 4-1 | Comiskey Park I (7-9) | 12-12 | Lost 2 |
| » W: Charles Hudson (3-1) L: Dave LaPoint (3-2) S: Cecilio Guante (2) | Third | 6 out |
| Wednesday, May 4 |
| » Defeated Red Sox (14-10), 6-2 | Fenway Park (1-0) | 13-12 | |
| » W: Jack McDowell (2-2) L: Roger Clemens (4-1) | Third | 6 out |
| Thursday, May 5 |
| » Lost to Red Sox (15-10), 16-3 | Fenway Park (1-1) | 13-13 | |
| » W: Bruce Hurst (5-0) L: Ricky Horton (3-4) | Third | 7 out |
| Saturday, May 7 |
| » Defeated Orioles (3-25), 11-7 | Memorial Stadium (1-0) | 14-13 | |
| » W: Bill Long (1-1) L: Jose Bautista (0-1) S: Bobby Thigpen (5) | Second | 7 out |
| Sunday, May 8 |
| » Lost to Orioles (4-25), 6-5 | Memorial Stadium (1-1) | 14-14 | |
| » W: Doug Sisk (1-1) L: Bobby Thigpen (0-3) | Second | 8 out |
| Monday, May 9 |
| » Defeated Orioles (4-26), 3-0 | Memorial Stadium (2-1) | 15-14 | |
| » W: Jerry Reuss (2-1) L: Mike Boddicker (0-7) S: Bobby Thigpen (6) | Second | 8 out |
| Tuesday, May 10 |
| » Lost to Yankees (21-11), 17-3 | Yankee Stadium (0-1) | 15-15 | |
| » W: John Candelaria (4-2) L: Ricky Horton (3-5) | Second | 8 out |
| Wednesday, May 11 |
| » Lost to Yankees (22-11), 12-2 | Yankee Stadium (0-2) | 15-16 | Lost 2 |
| » W: Richard Dotson (5-0) L: Jack McDowell (2-3) | Second | 8 out |
| Friday, May 13 |
| » Defeated Blue Jays (15-19), 4-1 | Comiskey Park I (8-9) | 16-16 | |
| » W: Melido Perez (3-0) L: Todd Stottlemyre (1-4) | Third | 7 out |
| Saturday, May 14 |
| » Defeated Blue Jays (15-20), 7-5 | Comiskey Park I (9-9) | 17-16 | Won 2 |
| » W: Dave LaPoint (4-2) L: John Cerutti (1-2) S: Bill Long (2) | Third | 7 out |
| Sunday, May 15 |
| » Defeated Blue Jays (15-21), 6-5 | Comiskey Park I (10-9) | 18-16 | Won 3 |
| » W: Bobby Thigpen (1-3) L: Mark Eichhorn (0-2) | Second | 7 out |
| Monday, May 16 |
| » Lost to Blue Jays (16-21), 5-1 | Comiskey Park I (10-10) | 18-17 | |
| » W: Dave Stieb (5-3) L: Ricky Horton (3-6) | Second | 8 out |
| Tuesday, May 17 |
| » Lost to Indians (23-14), 6-2 | Cleveland Stadium (0-1) | 18-18 | Lost 2 |
| » W: Rich Yett (3-2) L: Jack McDowell (2-4) S: Doug Jones (6) | Third | 9 out |
| Wednesday, May 18 |
| » Lost to Indians (24-14), 2-1 | Cleveland Stadium (0-2) | 18-19 | Lost 3 |
| » W: Tom Candiotti (6-1) L: Melido Perez (3-1) | Third | 9 out |
| Thursday, May 19 |
| » Lost to Indians (25-14), 1-0 | Cleveland Stadium (0-3) | 18-20 | Lost 4 |
| » W: Greg Swindell (8-1) L: Bobby Thigpen (1-4) | Fourth | 9½ out |
| Friday, May 20 |
| » Lost to Tigers (24-15), 14-6 | Comiskey Park I (10-11) | 18-21 | Lost 5 |
| » W: Frank Tanana (7-2) L: Jerry Reuss (2-2) | Fourth | 10½ out |
| Saturday, May 21 |
| » Lost to Tigers (25-15), 3-1 | Comiskey Park I (10-12) | 18-22 | Lost 6 |
| » W: Jack Morris (4-5) L: Jeff Bittiger (0-1) S: Mike Henneman (11) | Fourth | 10½ out |
| Sunday, May 22 |
| » Lost to Tigers (26-15), 3-1 | Comiskey Park I (10-13) | 18-23 | Lost 7 |
| » W: Walt Terrell (2-1) L: Jack McDowell (2-5) | Fifth | 10½ out |
| Monday, May 23 |
| » Defeated Indians (27-16), 3-2 | Comiskey Park I (11-13) | 19-23 | |
| » W: Melido Perez (4-1) L: Tom Candiotti (6-2) S: Bobby Thigpen (7) | Fifth | 9½ out |
| Tuesday, May 24 |
| » Lost to Indians (28-16), 4-3 | Comiskey Park I (11-14) | 19-24 | |
| » W: Greg Swindell (9-1) L: Dave LaPoint (4-3) S: Doug Jones (9) | Sixth | 10½ out |
| Wednesday, May 25 |
| » Lost to Indians (29-16), 5-2 | Comiskey Park I (11-15) | 19-25 | Lost 2 |
| » W: John Farrell (5-3) L: John Davis (1-2) | Sixth | 11½ out |
| Friday, May 27 |
| » Lost to Blue Jays (20-27), 4-3 | Exhibition Stadium (0-1) | 19-26 | Lost 3 |
| » W: Duane Ward (1-0) L: Bobby Thigpen (1-5) | Sixth | 12½ out |
| Saturday, May 28 |
| » Defeated Blue Jays (20-28), 3-2 | Exhibition Stadium (1-1) | 20-26 | |
| » W: Melido Perez (5-1) L: Todd Stottlemyre (1-7) S: Bobby Thigpen (8) | Sixth | 12½ out |
| Sunday, May 29 |
| » Lost to Blue Jays (21-28), 4-2 | Exhibition Stadium (1-2) | 20-27 | |
| » W: John Cerutti (3-2) L: Dave LaPoint (4-4) S: David Wells (3) | Sixth | 13½ out |
| Tuesday, May 31 |
| » Defeated Tigers (28-20), 10-1 | Tiger Stadium (1-0) | 21-27 | |
| » W: Jerry Reuss (3-2) L: Frank Tanana (8-3) | Fifth | 13 out |
| Wednesday, June 1 |
| » Lost to Tigers (29-20), 9-3 | Tiger Stadium (1-1) | 21-28 | |
| » W: Jack Morris (5-6) L: Jeff Bittiger (0-2) S: Willie Hernandez (3) | Sixth | 14 out |
| Thursday, June 2 |
| » Lost to Rangers (26-25), 10-2 | Comiskey Park I (11-16) | 21-29 | Lost 2 |
| » W: Charlie Hough (5-6) L: Melido Perez (5-2) | Sixth | 14½ out |
| Friday, June 3 |
| » Lost to Rangers (27-25), 9-3 | Comiskey Park I (11-17) | 21-30 | Lost 3 |
| » W: Ray Hayward (4-2) L: Dave LaPoint (4-5) | Sixth | 15½ out |
| Saturday, June 4 |
| » Defeated Rangers (27-26), 10-8 | Comiskey Park I (12-17) | 22-30 | |
| » W: Bobby Thigpen (2-5) L: Dale Mohorcic (2-3) | Fifth | 15½ out |
| » Major-league debuts: Steve Rosenberg (White Sox) |
| Sunday, June 5 |
| » Defeated Rangers (27-27), 5-4 | Comiskey Park I (13-17) | 23-30 | Won 2 |
| » W: Jerry Reuss (4-2) L: Paul Kilgus (6-4) S: Bobby Thigpen (9) | Fifth | 14½ out |
| Monday, June 6 |
| » Lost to Twins (28-25), 9-4 | Comiskey Park I (13-18) | 23-31 | |
| » W: Juan Berenguer (6-3) L: Bill Long (1-2) | Fifth | 14½ out |
| Tuesday, June 7 |
| » Defeated Twins (28-26), 10-8 | Comiskey Park I (14-18) | 24-31 | |
| » W: Ricky Horton (4-6) L: Keith Atherton (4-2) S: Bobby Thigpen (10) | Fifth | 13½ out |
| Wednesday, June 8 |
| » Lost to Twins (29-26), 5-2 | Comiskey Park I (14-19) | 24-32 | |
| » W: Juan Berenguer (7-3) L: Dave LaPoint (4-6) | Fifth | 13½ out |
| Friday, June 10 |
| » Defeated Brewers (30-29), 1-0 | Comiskey Park I (15-19) | 25-32 | |
| » W: Bill Long (2-2) L: Teddy Higuera (5-4) | Fifth | 13 out |
| Saturday, June 11 |
| » Defeated Brewers (30-30), 5-3 | Comiskey Park I (16-19) | 26-32 | Won 2 |
| » W: Jerry Reuss (5-2) L: Paul Mirabella (0-2) S: Bobby Thigpen (11) | Fifth | 13 out |
| Sunday, June 12 |
| » Lost to Brewers (31-30), 16-2 | Comiskey Park I (16-20) | 26-33 | |
| » W: Don August (2-1) L: Joel Davis (0-1) | Fifth | 13 out |
| Monday, June 13 |
| » Defeated Twins (32-28), 4-1 | Hubert H. Humphrey Metrodome (1-0) | 27-33 | |
| » W: Melido Perez (6-2) L: Les Straker (2-4) S: Bobby Thigpen (12) | Fifth | 12½ out |
| Tuesday, June 14 |
| » Lost to Twins (33-28), 3-1 | Hubert H. Humphrey Metrodome (1-1) | 27-34 | |
| » W: Bert Blyleven (5-6) L: Dave LaPoint (4-7) S: Jeff Reardon (17) | Fifth | 12½ out |
| Wednesday, June 15 |
| » Lost to Twins (34-28), 5-1 | Hubert H. Humphrey Metrodome (1-2) | 27-35 | Lost 2 |
| » W: Allan Anderson (4-3) L: Jack McDowell (2-6) S: Keith Atherton (2) | Fifth | 12½ out |
| Thursday, June 16 |
| » Defeated Brewers (34-31), 3-1 | County Stadium (1-0) | 28-35 | |
| » W: Jerry Reuss (6-2) L: Chris Bosio (6-7) S: Bobby Thigpen (13) | Fifth | 11½ out |
| Friday, June 17 |
| » Lost to Brewers (35-31), 7-2 | County Stadium (1-1) | 28-36 | |
| » W: Don August (3-1) L: Bill Long (2-3) S: Chuck Crim (3) | Fifth | 12½ out |
| Saturday, June 18 |
| » Lost to Brewers (36-31), 6-3 | County Stadium (1-2) | 28-37 | Lost 2 |
| » W: Bill Wegman (6-5) L: Melido Perez (6-3) S: Dan Plesac (16) | Fifth | 13½ out |
| Sunday, June 19 |
| » Defeated Brewers (36-32), 5-0 | County Stadium (2-2) | 29-37 | |
| » W: Dave LaPoint (5-7) L: Tom Filer (4-1) | Fifth | 12½ out |
| Monday, June 20 |
| » Defeated Royals (36-33), 5-3 | Comiskey Park I (17-20) | 30-37 | Won 2 |
| » W: Bobby Thigpen (3-5) L: Jeff Montgomery (0-1) | Fifth | 12½ out |
| Tuesday, June 21 |
| » Lost to Royals (37-33), 6-2 | Comiskey Park I (17-21) | 30-38 | |
| » W: Mark Gubicza (10-5) L: Jerry Reuss (6-3) | Fifth | 13½ out |
| Wednesday, June 22 |
| » Defeated Royals (37-34), 5-4 | Comiskey Park I (18-21) | 31-38 | |
| » W: Bobby Thigpen (4-5) L: Steve Farr (2-1) | Fifth | 13½ out |
| Former White Sox Hank Edwards dies in Santa Ana, CA at the age of 70. |
| Friday, June 24 |
| » Lost to Rangers (35-36), 5-2 | Arlington Stadium (0-1) | 31-39 | |
| » W: Charlie Hough (7-7) L: Melido Perez (6-4) | Fifth | 13½ out |
| Saturday, June 25 |
| » Defeated Rangers (35-37), 10-5 | Arlington Stadium (1-1) | 32-39 | |
| » W: Dave LaPoint (6-7) L: Ray Hayward (4-5) | Fifth | 13½ out |
| Sunday, June 26 |
| » Defeated Rangers (35-38), 7-5 | Arlington Stadium (2-1) | 33-39 | Won 2 |
| » W: Jack McDowell (3-6) L: Jeff Russell (7-1) S: Bobby Thigpen (14) | Fifth | 12 out |
| Monday, June 27 |
| » Lost to Royals (39-36), 2-1 | Royals Stadium (0-1) | 33-40 | |
| » W: Mark Gubicza (11-5) L: Jerry Reuss (6-4) S: Jerry Don Gleaton (3) | Fifth | 13 out |
| Tuesday, June 28 |
| » Defeated Royals (39-37), 4-3 | Royals Stadium (1-1) | 34-40 | |
| » W: Bill Long (3-3) L: Gene Garber (0-4) S: Bobby Thigpen (15) | Fifth | 12 out |
| Wednesday, June 29 |
| » Lost to Royals (40-37), 9-8 | Royals Stadium (1-2) | 34-41 | |
| » W: Floyd Bannister (8-6) L: Melido Perez (6-5) S: Steve Farr (5) | Fifth | 13 out |
| Thursday, June 30 |
| » Lost to Yankees (45-31), 5-3 | Comiskey Park I (18-22) | 34-42 | Lost 2 |
| » W: Tommy John (6-2) L: Dave LaPoint (6-8) S: Dave Righetti (11) | Fifth | 13½ out |
| Friday, July 1 |
| » Defeated Yankees (45-32), 2-1 | Comiskey Park I (19-22) | 35-42 | |
| » W: Bobby Thigpen (5-5) L: Steve Shields (1-3) | Fifth | 13½ out |
| Saturday, July 2 |
| » Lost to Yankees (46-32), 4-0 | Comiskey Park I (19-23) | 35-43 | |
| » W: John Candelaria (9-4) L: Jerry Reuss (6-5) | Fifth | 14½ out |
| Sunday, July 3 |
| » Defeated Yankees (46-33), 4-3 | Comiskey Park I (20-23) | 36-43 | |
| » W: Jeff Bittiger (1-2) L: Cecilio Guante (4-5) | Fifth | 14½ out |
| Monday, July 4 |
| » Defeated Orioles (24-57), 5-1 | Comiskey Park I (21-23) | 37-43 | Won 2 |
| » W: Melido Perez (7-5) L: Jay Tibbs (3-5) | Fifth | 14½ out |
| Tuesday, July 5 |
| » Lost to Orioles (25-57), 5-1 | Comiskey Park I (21-24) | 37-44 | |
| » W: Jose Bautista (4-6) L: Dave LaPoint (6-9) | Fifth | 14 out |
| Wednesday, July 6 |
| » Defeated Orioles (25-58), 4-1 | Comiskey Park I (22-24) | 38-44 | |
| » W: Jack McDowell (4-6) L: Mike Boddicker (4-11) S: Ricky Horton (1) | Fifth | 13 out |
| Friday, July 8 |
| » Defeated Red Sox (41-40), 6-5 | Comiskey Park I (23-24) | 39-44 | Won 2 |
| » W: John Davis (2-2) L: Mike Smithson (3-3) S: Bobby Thigpen (16) | Fifth | 13 out |
| » Lost to Red Sox (42-40), 10-7 | Comiskey Park I (23-25) | 39-45 | |
| » W: Dennis Lamp (3-3) L: Bill Long (3-4) | Fifth | 13 out |
| Saturday, July 9 |
| » Defeated Red Sox (42-41), 8-7 | Comiskey Park I (24-25) | 40-45 | |
| » W: Melido Perez (8-5) L: Tom Bolton (0-1) S: Bobby Thigpen (17) | Fifth | 12½ out |
| » Lost to Red Sox (43-41), 8-2 | Comiskey Park I (24-26) | 40-46 | |
| » W: Lee Smith (3-4) L: Ricky Horton (4-7) | Fifth | 12½ out |
| » Major-league debuts: Ken Patterson (White Sox) |
| Sunday, July 10 |
| » Defeated Red Sox (43-42), 4-1 | Comiskey Park I (25-26) | 41-46 | |
| » W: Dave LaPoint (7-9) L: Steve Curry (0-1) S: Bobby Thigpen (18) | Fourth | 12½ out |
| Thursday, July 14 |
| » Lost to Yankees (50-36), 7-5 | Yankee Stadium (0-3) | 41-47 | |
| » W: John Candelaria (10-5) L: Jerry Reuss (6-6) S: Cecilio Guante (10) | Fifth | 12½ out |
| Friday, July 15 |
| » Lost to Yankees (51-36), 5-3 | Yankee Stadium (0-4) | 41-48 | Lost 2 |
| » W: Rick Rhoden (5-6) L: Jack McDowell (4-7) S: Cecilio Guante (11) | Fifth | 12½ out |
| Saturday, July 16 |
| » Defeated Yankees (51-37), 7-4 | Yankee Stadium (1-4) | 42-48 | |
| » W: Melido Perez (9-5) L: Tommy John (7-3) S: Bobby Thigpen (19) | Fifth | 12½ out |
| Sunday, July 17 |
| » Lost to Yankees (52-37), 7-3 | Yankee Stadium (1-5) | 42-49 | |
| » W: Ron Guidry (1-1) L: Dave LaPoint (7-10) S: Tim Stoddard (3) | Fifth | 12½ out |
| Tuesday, July 19 |
| » Lost to Orioles (30-63), 6-4 | Memorial Stadium (2-2) | 42-50 | Lost 2 |
| » W: Mike Boddicker (6-11) L: Jerry Reuss (6-7) S: Tom Niedenfuer (10) | Fifth | 14 out |
| » Defeated Orioles (30-64), 2-0 | Memorial Stadium (3-2) | 43-50 | |
| » W: Bill Long (4-4) L: Jay Tibbs (4-7) S: Bobby Thigpen (20) | Fifth | 14 out |
| Thursday, July 21 |
| » Lost to Red Sox (51-42), 6-1 | Fenway Park (1-2) | 43-51 | |
| » W: Oil Can Boyd (8-7) L: Jack McDowell (4-8) S: Bob Stanley (2) | Fifth | 14 out |
| Friday, July 22 |
| » Lost to Red Sox (52-42), 4-3 | Fenway Park (1-3) | 43-52 | Lost 2 |
| » W: Wes Gardner (4-1) L: John Davis (2-3) S: Lee Smith (14) | Fifth | 15 out |
| Saturday, July 23 |
| » Lost to Red Sox (53-42), 11-5 | Fenway Park (1-4) | 43-53 | Lost 3 |
| » W: Mike Smithson (6-3) L: Dave LaPoint (7-11) | Sixth | 16 out |
| Sunday, July 24 |
| » Lost to Red Sox (54-42), 3-2 | Fenway Park (1-5) | 43-54 | Lost 4 |
| » W: Bruce Hurst (10-4) L: Bill Long (4-5) S: Lee Smith (15) | Sixth | 17 out |
| Former White Sox Joe Orengo dies in San Francisco, CA at the age of 74. |
| Monday, July 25 |
| » Defeated Mariners (39-60), 6-5 | Comiskey Park I (26-26) | 44-54 | |
| » W: Jerry Reuss (7-7) L: Mike Moore (4-11) S: Bobby Thigpen (21) | Sixth | 16 out |
| Tuesday, July 26 |
| » Defeated Mariners (39-61), 1-0 | Comiskey Park I (27-26) | 45-54 | Won 2 |
| » W: Ricky Horton (5-7) L: Mike Schooler (2-4) | Sixth | 16 out |
| Wednesday, July 27 |
| » Defeated Mariners (39-62), 6-1 | Comiskey Park I (28-26) | 46-54 | Won 3 |
| » W: Melido Perez (10-5) L: Bill Swift (6-8) | Fourth | 15 out |
| Thursday, July 28 |
| » Lost to Angels (50-51), 7-6 | Comiskey Park I (28-27) | 46-55 | |
| » W: Donnie Moore (5-2) L: Ricky Horton (5-8) | Sixth | 15½ out |
| Friday, July 29 |
| » Lost to Angels (51-51), 4-2 | Comiskey Park I (28-28) | 46-56 | Lost 2 |
| » W: Willie Fraser (7-10) L: Bill Long (4-6) S: Bryan Harvey (11) | Sixth | 15½ out |
| Saturday, July 30 |
| » Lost to Angels (52-51), 15-14 | Comiskey Park I (28-29) | 46-57 | Lost 3 |
| » W: Sherman Corbett (1-0) L: John Davis (2-4) | Sixth | 16½ out |
| Sunday, July 31 |
| » Lost to Angels (53-51), 7-5 | Comiskey Park I (28-30) | 46-58 | Lost 4 |
| » W: Mike Witt (8-10) L: Ricky Horton (5-9) S: Greg Minton (5) | Sixth | 17½ out |
| Monday, August 1 |
| » Lost to Athletics (65-41), 10-2 | Comiskey Park I (28-31) | 46-59 | Lost 5 |
| » W: Todd Burns (4-0) L: Melido Perez (10-6) | Sixth | 18½ out |
| » Major-league debuts: Donn Pall (White Sox) |
| Tuesday, August 2 |
| » Defeated Athletics (65-42), 7-5 | Comiskey Park I (29-31) | 47-59 | |
| » W: Dave LaPoint (8-11) L: Steve Ontiveros (3-4) S: Bobby Thigpen (22) | Fifth | 17½ out |
| Wednesday, August 3 |
| » Lost to Athletics (66-42), 4-3 | Comiskey Park I (29-32) | 47-60 | |
| » W: Gene Nelson (6-3) L: Bobby Thigpen (5-6) S: Dennis Eckersley (31) | Fifth | 18½ out |
| Friday, August 5 |
| » Lost to Angels (56-52), 6-5 | Anaheim Stadium (0-3) | 47-61 | Lost 2 |
| » W: Sherman Corbett (2-0) L: Donn Pall (0-1) | Sixth | 19½ out |
| » Defeated Angels (56-53), 5-4 | Anaheim Stadium (1-3) | 48-61 | |
| » W: Ricky Horton (6-9) L: Greg Minton (3-2) S: Bobby Thigpen (23) | Sixth | 19½ out |
| Saturday, August 6 |
| » Lost to Angels (57-53), 7-5 | Anaheim Stadium (1-4) | 48-62 | |
| » W: Terry Clark (5-0) L: Melido Perez (10-7) S: Greg Minton (6) | Sixth | 20½ out |
| Sunday, August 7 |
| » Defeated Angels (57-54), 6-3 | Anaheim Stadium (2-4) | 49-62 | |
| » W: Dave LaPoint (9-11) L: Chuck Finley (6-10) S: Bobby Thigpen (24) | Sixth | 19½ out |
| Monday, August 8 |
| » Lost to Athletics (70-43), 9-5 | Oakland-Alameda County Stadium (3-1) | 49-63 | |
| » W: Bob Welch (13-6) L: Bill Long (4-7) S: Dennis Eckersley (33) | Sixth | 20½ out |
| Tuesday, August 9 |
| » Lost to Athletics (71-43), 8-1 | Oakland-Alameda County Stadium (3-2) | 49-64 | Lost 2 |
| » W: Dave Stewart (15-10) L: Jeff Bittiger (1-3) | Sixth | 21½ out |
| Wednesday, August 10 |
| » Lost to Athletics (72-43), 2-1 | Oakland-Alameda County Stadium (3-3) | 49-65 | Lost 3 |
| » W: Greg Cadaret (4-1) L: Ricky Horton (6-10) | Sixth | 22½ out |
| Thursday, August 11 |
| » Defeated Mariners (44-71), 4-3 | Kingdome (3-1) | 50-65 | |
| » W: Jerry Reuss (8-7) L: Mike Jackson (6-4) S: Bobby Thigpen (25) | Sixth | 22½ out |
| Friday, August 12 |
| » Defeated Mariners (44-72), 7-2 | Kingdome (4-1) | 51-65 | Won 2 |
| » W: Dave LaPoint (10-11) L: Dennis Powell (1-3) | Sixth | 22½ out |
| Saturday, August 13 |
| » Defeated Mariners (44-73), 7-4 | Kingdome (5-1) | 52-65 | Won 3 |
| » W: Melido Perez (11-7) L: Mark Langston (8-10) S: Ricky Horton (2) | Sixth | 22½ out |
| Sunday, August 14 |
| » Lost to Mariners (45-73), 11-0 | Kingdome (5-2) | 52-66 | |
| » W: Mike Moore (6-13) L: Bill Long (4-8) | Sixth | 22½ out |
| Tuesday, August 16 |
| » Defeated Blue Jays (60-60), 5-4 | Comiskey Park I (30-32) | 53-66 | |
| » W: Jack McDowell (5-8) L: Jimmy Key (7-3) S: Bobby Thigpen (26) | Fifth | 22½ out |
| Wednesday, August 17 |
| » Defeated Blue Jays (60-61), 5-1 | Comiskey Park I (31-32) | 54-66 | Won 2 |
| » W: Jerry Reuss (9-7) L: Jim Clancy (6-13) S: Steve Rosenberg (1) | Fifth | 22½ out |
| Thursday, August 18 |
| » Lost to Tigers (70-50), 6-4 | Tiger Stadium (1-2) | 54-67 | |
| » W: Mike Henneman (6-2) L: Bobby Thigpen (5-7) | Fifth | 22½ out |
| Friday, August 19 |
| » Lost to Tigers (71-50), 5-4 | Tiger Stadium (1-3) | 54-68 | Lost 2 |
| » W: Frank Tanana (14-7) L: Bill Long (4-9) S: Willie Hernandez (6) | Sixth | 22½ out |
| Saturday, August 20 |
| » Lost to Tigers (72-50), 2-1 | Tiger Stadium (1-4) | 54-69 | Lost 3 |
| » W: Walt Terrell (7-10) L: Jeff Bittiger (1-4) S: Willie Hernandez (7) | Sixth | 22½ out |
| Sunday, August 21 |
| » Lost to Tigers (73-50), 5-0 | Tiger Stadium (1-5) | 54-70 | Lost 4 |
| » W: Jack Morris (11-12) L: Jack McDowell (5-9) | Sixth | 23½ out |
| Monday, August 22 |
| » Lost to Blue Jays (62-63), 6-3 | Exhibition Stadium (1-3) | 54-71 | Lost 5 |
| » W: Dave Stieb (12-8) L: Jerry Reuss (9-8) | Sixth | 24½ out |
| Tuesday, August 23 |
| » Lost to Blue Jays (63-63), 7-2 | Exhibition Stadium (1-4) | 54-72 | Lost 6 |
| » W: Jim Clancy (7-13) L: Melido Perez (11-8) S: Duane Ward (10) | Sixth | 24½ out |
| Wednesday, August 24 |
| » Defeated Blue Jays (63-64), 6-4 | Exhibition Stadium (2-4) | 55-72 | |
| » W: Bill Long (5-9) L: Jeff Musselman (5-2) S: Bobby Thigpen (27) | Sixth | 23½ out |
| Friday, August 26 |
| » Lost to Indians (62-66), 7-6 | Comiskey Park I (31-33) | 55-73 | |
| » W: Greg Swindell (14-12) L: Jack McDowell (5-10) S: Doug Jones (30) | Sixth | 24½ out |
| Saturday, August 27 |
| » Defeated Indians (62-67), 4-1 | Comiskey Park I (32-33) | 56-73 | |
| » W: Jerry Reuss (10-8) L: John Farrell (13-9) | Sixth | 24½ out |
| Sunday, August 28 |
| » Lost to Indians (63-67), 5-4 | Comiskey Park I (32-34) | 56-74 | |
| » W: Doug Jones (2-3) L: Barry Jones (1-2) | Sixth | 24½ out |
| Monday, August 29 |
| » Defeated Tigers (74-56), 3-2 | Comiskey Park I (33-34) | 57-74 | |
| » W: Bill Long (6-9) L: Steve Searcy (0-1) S: Bobby Thigpen (28) | Sixth | 24½ out |
| » Major-league debuts: Steve Searcy (Tigers) |
| Tuesday, August 30 |
| » Defeated Tigers (74-57), 4-1 | Comiskey Park I (34-34) | 58-74 | Won 2 |
| » W: Jeff Bittiger (2-4) L: Walt Terrell (7-11) S: Barry Jones (3) | Sixth | 24½ out |
| Wednesday, August 31 |
| » Lost to Tigers (75-57), 9-3 | Comiskey Park I (34-35) | 58-75 | |
| » W: Jack Morris (12-12) L: John Davis (2-5) | Sixth | 25½ out |
| Friday, September 2 |
| » Lost to Indians (65-69), 4-3 | Cleveland Stadium (0-4) | 58-76 | Lost 2 |
| » W: Doug Jones (3-3) L: Ken Patterson (0-1) | Sixth | 25½ out |
| » Major-league debuts: Luis Medina (Indians) Carlos Martinez (White Sox) |
| Saturday, September 3 |
| » Major-league debuts: Gary Sheffield (Brewers) |
| Sunday, September 4 |
| » Lost to Indians (66-69), 3-2 | Cleveland Stadium (0-5) | 58-77 | Lost 3 |
| » W: Brad Havens (2-2) L: Barry Jones (1-3) | Sixth | 26½ out |
| » Defeated Indians (66-70), 5-2 | Cleveland Stadium (1-5) | 59-77 | |
| » W: Bill Long (7-9) L: Doug Jones (3-4) S: Bobby Thigpen (29) | Sixth | 26½ out |
| Monday, September 5 |
| » Lost to Brewers (74-67), 5-2 | County Stadium (2-3) | 59-78 | |
| » W: Don August (9-6) L: Shawn Hillegas (3-5) S: Juan Nieves (1) | Sixth | 27½ out |
| Wednesday, September 7 |
| » Defeated Brewers (74-68), 7-2 | County Stadium (3-3) | 60-78 | |
| » W: Jerry Reuss (11-8) L: Mike Birkbeck (10-7) S: Bobby Thigpen (30) | Sixth | 27 out |
| Friday, September 9 |
| » Lost to Twins (78-62), 1-0 | Comiskey Park I (34-36) | 60-79 | |
| » W: Freddie Toliver (7-3) L: Bill Long (7-10) S: Jeff Reardon (37) | Sixth | 28½ out |
| Saturday, September 10 |
| » Lost to Twins (79-62), 6-5 | Comiskey Park I (34-37) | 60-80 | Lost 2 |
| » W: Mark Portugal (3-2) L: Steve Rosenberg (0-1) S: German Gonzalez (1) | Sixth | 28½ out |
| Sunday, September 11 |
| » Defeated Twins (79-63), 3-2 | Comiskey Park I (35-37) | 61-80 | |
| » W: Shawn Hillegas (4-5) L: Bert Blyleven (9-15) S: Ken Patterson (1) | Sixth | 28½ out |
| Monday, September 12 |
| » Defeated Brewers (76-70), 2-1 | Comiskey Park I (36-37) | 62-80 | Won 2 |
| » W: Barry Jones (2-3) L: Dan Plesac (1-2) | Sixth | 28 out |
| Tuesday, September 13 |
| » Lost to Brewers (77-70), 4-0 | Comiskey Park I (36-38) | 62-81 | |
| » W: Juan Nieves (6-5) L: Ken Patterson (0-2) | Sixth | 29 out |
| Wednesday, September 14 |
| » Lost to Brewers (78-70), 4-2 | Comiskey Park I (36-39) | 62-82 | Lost 2 |
| » W: Bill Wegman (12-11) L: Bill Long (7-11) S: Paul Mirabella (2) | Sixth | 29 out |
| Thursday, September 15 |
| » Lost to Twins (81-65), 10-3 | Hubert H. Humphrey Metrodome (1-3) | 62-83 | Lost 3 |
| » W: Frank Viola (22-6) L: Melido Perez (11-9) | Sixth | 30 out |
| Friday, September 16 |
| » Lost to Twins (82-65), 5-4 | Hubert H. Humphrey Metrodome (1-4) | 62-84 | Lost 4 |
| » W: Bert Blyleven (10-15) L: Shawn Hillegas (4-6) S: Jeff Reardon (39) | Sixth | 30 out |
| Saturday, September 17 |
| » Lost to Twins (83-65), 3-1 | Hubert H. Humphrey Metrodome (1-5) | 62-85 | Lost 5 |
| » W: Allan Anderson (14-9) L: Jerry Reuss (11-9) S: Jeff Reardon (40) | Sixth |