| Tuesday, April 5 |
| » Lost to Yankees (1-0), 8-0 | Yankee Stadium (0-1) | 0-1 | |
| » W: Rick Rhoden (1-0) L: Frank Viola (0-1) | Third | 1½ out |
| Wednesday, April 6 |
| » Lost to Yankees (2-0), 5-3 | Yankee Stadium (0-2) | 0-2 | Lost 2 |
| » W: Cecilio Guante (1-0) L: Juan Berenguer (0-1) S: Dave Righetti (1) | Fourth | 1½ out |
| Friday, April 8 |
| » Defeated Blue Jays (2-2), 6-3 | Hubert H. Humphrey Metrodome (1-0) | 1-2 | |
| » W: Bert Blyleven (1-0) L: Dave Stieb (0-1) S: Jeff Reardon (1) | Third | 1½ out |
| Saturday, April 9 |
| » Lost to Blue Jays (3-2), 10-0 | Hubert H. Humphrey Metrodome (1-1) | 1-3 | |
| » W: Jimmy Key (2-0) L: Charlie Lea (0-1) S: Duane Ward (1) | Fourth | 2½ out |
| Sunday, April 10 |
| » Defeated Blue Jays (3-3), 4-2 | Hubert H. Humphrey Metrodome (2-1) | 2-3 | |
| » W: Frank Viola (1-1) L: Todd Stottlemyre (0-1) S: Jeff Reardon (2) | Third | 1½ out |
| Tuesday, April 12 |
| » Defeated Indians (6-2), 7-6 | Cleveland Stadium (1-0) | 3-3 | Won 2 |
| » W: Joe Niekro (1-0) L: Chris Codiroli (0-2) S: Jeff Reardon (3) | Second | ½ out |
| Wednesday, April 13 |
| » Lost to Indians (7-2), 6-3 | Cleveland Stadium (1-1) | 3-4 | |
| » W: Jeff Dedmon (1-0) L: Juan Berenguer (0-2) | Third | 1½ out |
| Thursday, April 14 |
| » Lost to Indians (8-2), 3-1 | Cleveland Stadium (1-2) | 3-5 | Lost 2 |
| » W: Tom Candiotti (2-0) L: Charlie Lea (0-2) | Fourth | 2½ out |
| Saturday, April 16 |
| » Defeated Blue Jays (4-7), 3-2 | Exhibition Stadium (1-0) | 4-5 | |
| » W: Juan Berenguer (1-2) L: David Wells (1-1) S: Jeff Reardon (4) | Fifth | 1½ out |
| Sunday, April 17 |
| » Lost to Blue Jays (5-7), 2-0 | Exhibition Stadium (1-1) | 4-6 | |
| » W: Mike Flanagan (2-0) L: Les Straker (0-1) S: Tom Henke (2) | Fifth | 1½ out |
| Monday, April 18 |
| » Lost to Yankees (10-3), 18-5 | Hubert H. Humphrey Metrodome (2-2) | 4-7 | Lost 2 |
| » W: Charles Hudson (1-0) L: Bert Blyleven (1-1) | Sixth | 2½ out |
| Tuesday, April 19 |
| » Lost to Yankees (11-3), 7-6 | Hubert H. Humphrey Metrodome (2-3) | 4-8 | Lost 3 |
| » W: Al Leiter (3-0) L: Joe Niekro (1-1) S: Dave Righetti (4) | Fifth | 3½ out |
| Wednesday, April 20 |
| » Lost to Yankees (12-3), 7-6 | Hubert H. Humphrey Metrodome (2-4) | 4-9 | Lost 4 |
| » W: Dave Righetti (1-0) L: Jeff Reardon (0-1) | Fifth | 4 out |
| Friday, April 22 |
| » Lost to Indians (13-3), 11-6 | Hubert H. Humphrey Metrodome (2-5) | 4-10 | Lost 5 |
| » W: Greg Swindell (4-0) L: Bert Blyleven (1-2) S: Doug Jones (3) | Seventh | 4½ out |
| Saturday, April 23 |
| » Lost to Indians (14-3), 10-2 | Hubert H. Humphrey Metrodome (2-6) | 4-11 | Lost 6 |
| » W: John Farrell (3-0) L: Steve Carlton (0-1) | Seventh | 5½ out |
| Sunday, April 24 |
| » Defeated Indians (14-4), 13-7 | Hubert H. Humphrey Metrodome (3-6) | 5-11 | |
| » W: Juan Berenguer (2-2) L: Scott Bailes (1-2) | Seventh | 5½ out |
| Tuesday, April 26 |
| » Defeated Orioles (0-19), 4-2 | Hubert H. Humphrey Metrodome (4-6) | 6-11 | Won 2 |
| » W: Frank Viola (2-1) L: Mike Morgan (0-4) S: Jeff Reardon (5) | Sixth | 5½ out |
| » Major-league debuts: Craig Worthington (Orioles) |
| Wednesday, April 27 |
| » Defeated Orioles (0-20), 7-6 | Hubert H. Humphrey Metrodome (5-6) | 7-11 | Won 3 |
| » W: Juan Berenguer (3-2) L: Bill Scherrer (0-1) S: Keith Atherton (1) | Seventh | 5½ out |
| Thursday, April 28 |
| » Defeated Orioles (0-21), 4-2 | Hubert H. Humphrey Metrodome (6-6) | 8-11 | Won 4 |
| » W: Allan Anderson (1-0) L: Mike Boddicker (0-5) S: Mark Portugal (1) | Fifth | 5½ out |
| Friday, April 29 |
| » Lost to Red Sox (13-6), 6-5 | Fenway Park (0-1) | 8-12 | |
| » W: Lee Smith (2-1) L: Juan Berenguer (3-3) | Sixth | 6 out |
| Saturday, April 30 |
| » Lost to Red Sox (14-6), 8-3 | Fenway Park (0-2) | 8-13 | Lost 2 |
| » W: Bruce Hurst (4-0) L: Charlie Lea (0-3) S: Wes Gardner (1) | Sixth | 7 out |
| Sunday, May 1 |
| » Defeated Red Sox (14-7), 2-0 | Fenway Park (1-2) | 9-13 | |
| » W: Frank Viola (3-1) L: Jeff Sellers (0-2) | Fifth | 7 out |
| Monday, May 2 |
| » Lost to Brewers (11-11), 4-3 | County Stadium (0-1) | 9-14 | |
| » W: Juan Nieves (3-2) L: Bert Blyleven (1-3) S: Odell Jones (1) | Sixth | 8 out |
| Tuesday, May 3 |
| » Lost to Brewers (12-11), 4-3 | County Stadium (0-2) | 9-15 | Lost 2 |
| » W: Teddy Higuera (3-1) L: Allan Anderson (1-1) | Seventh | 9 out |
| Wednesday, May 4 |
| » Lost to Orioles (3-24), 4-3 | Memorial Stadium (0-1) | 9-16 | Lost 3 |
| » W: Dave Schmidt (1-1) L: Keith Atherton (0-1) | Seventh | 10 out |
| Friday, May 6 |
| » Defeated Red Sox (15-11), 5-0 | Hubert H. Humphrey Metrodome (7-6) | 10-16 | |
| » W: Frank Viola (4-1) L: Jeff Sellers (0-3) | Sixth | 10 out |
| Saturday, May 7 |
| » Defeated Red Sox (15-12), 5-2 | Hubert H. Humphrey Metrodome (8-6) | 11-16 | Won 2 |
| » W: Bert Blyleven (2-3) L: Steve Ellsworth (1-4) | Sixth | 10 out |
| Sunday, May 8 |
| » Lost to Red Sox (16-12), 10-6 | Hubert H. Humphrey Metrodome (8-7) | 11-17 | |
| » W: Oil Can Boyd (3-2) L: Mike Mason (0-1) | Sixth | 11 out |
| Monday, May 9 |
| » Lost to Brewers (18-11), 9-6 | Hubert H. Humphrey Metrodome (8-8) | 11-18 | Lost 2 |
| » W: Odell Jones (1-0) L: Jeff Reardon (0-2) S: Chuck Crim (2) | Seventh | 12 out |
| Tuesday, May 10 |
| » Defeated Brewers (18-12), 9-3 | Hubert H. Humphrey Metrodome (9-8) | 12-18 | |
| » W: Frank Viola (5-1) L: Bill Wegman (3-4) | Sixth | 11 out |
| Wednesday, May 11 |
| » Defeated Brewers (18-13), 2-1 | Hubert H. Humphrey Metrodome (10-8) | 13-18 | Won 2 |
| » W: Keith Atherton (1-1) L: Chris Bosio (5-3) S: Jeff Reardon (6) | Fifth | 10 out |
| Friday, May 13 |
| » Lost to Tigers (21-12), 7-0 | Tiger Stadium (0-1) | 13-19 | |
| » W: Doyle Alexander (3-2) L: Allan Anderson (1-2) | Sixth | 10 out |
| Saturday, May 14 |
| » Defeated Tigers (21-13), 7-0 | Tiger Stadium (1-1) | 14-19 | |
| » W: Les Straker (1-1) L: Frank Tanana (6-2) | Fifth | 10 out |
| Sunday, May 15 |
| » Defeated Tigers (21-14), 10-2 | Tiger Stadium (2-1) | 15-19 | Won 2 |
| » W: Frank Viola (6-1) L: Jack Morris (3-5) | Fifth | 10 out |
| Tuesday, May 17 |
| » Defeated Royals (17-20), 6-5 | Hubert H. Humphrey Metrodome (11-8) | 16-19 | Won 3 |
| » W: Juan Berenguer (4-3) L: Gene Garber (0-1) | Fifth | 10½ out |
| Wednesday, May 18 |
| » Lost to Royals (18-20), 8-2 | Hubert H. Humphrey Metrodome (11-9) | 16-20 | |
| » W: Bret Saberhagen (5-4) L: Allan Anderson (1-3) | Fifth | 10½ out |
| Thursday, May 19 |
| » Lost to Royals (19-20), 14-1 | Hubert H. Humphrey Metrodome (11-10) | 16-21 | Lost 2 |
| » W: Charlie Leibrandt (2-6) L: Les Straker (1-2) | Fifth | 11 out |
| Saturday, May 21 |
| » Lost to Rangers (21-18), 3-0 | Arlington Stadium (0-1) | 16-22 | Lost 3 |
| » W: Paul Kilgus (6-3) L: Bert Blyleven (2-4) | Sixth | 11½ out |
| Sunday, May 22 |
| » Defeated Rangers (21-19), 15-5 | Arlington Stadium (1-1) | 17-22 | |
| » W: Les Straker (2-2) L: Charlie Hough (4-6) | Fourth | 10 out |
| » Defeated Rangers (21-20), 4-2 | Arlington Stadium (2-1) | 18-22 | Won 2 |
| » W: Frank Viola (7-1) L: Jose Guzman (4-3) S: Jeff Reardon (7) | Fourth | 10 out |
| Monday, May 23 |
| » Defeated Royals (20-23), 7-5 | Royals Stadium (1-0) | 19-22 | Won 3 |
| » W: Keith Atherton (2-1) L: Bret Saberhagen (5-5) S: Jeff Reardon (8) | Fourth | 9 out |
| Tuesday, May 24 |
| » Defeated Royals (20-24), 6-5 | Royals Stadium (2-0) | 20-22 | Won 4 |
| » W: Charlie Lea (1-3) L: Charlie Leibrandt (2-7) S: Jeff Reardon (9) | Third | 9 out |
| Wednesday, May 25 |
| » Defeated Royals (20-25), 4-2 | Royals Stadium (3-0) | 21-22 | Won 5 |
| » W: Bert Blyleven (3-4) L: Mark Gubicza (5-5) S: Jeff Reardon (10) | Third | 9 out |
| Friday, May 27 |
| » Defeated Tigers (28-17), 7-1 | Hubert H. Humphrey Metrodome (12-10) | 22-22 | Won 6 |
| » W: Frank Viola (8-1) L: Jack Morris (4-6) | Third | 9 out |
| Saturday, May 28 |
| » Defeated Tigers (28-18), 5-2 | Hubert H. Humphrey Metrodome (13-10) | 23-22 | Won 7 |
| » W: Keith Atherton (3-1) L: Walt Terrell (2-2) S: Jeff Reardon (11) | Third | 9 out |
| Sunday, May 29 |
| » Defeated Tigers (28-19), 6-3 | Hubert H. Humphrey Metrodome (14-10) | 24-22 | Won 8 |
| » W: Allan Anderson (2-3) L: Doyle Alexander (4-4) S: Jeff Reardon (12) | Second | 9 out |
| Monday, May 30 |
| » Lost to Rangers (25-23), 6-1 | Hubert H. Humphrey Metrodome (14-11) | 24-23 | |
| » W: Jeff Russell (4-0) L: Bert Blyleven (3-5) | Third | 10 out |
| Tuesday, May 31 |
| » Defeated Rangers (25-24), 8-6 | Hubert H. Humphrey Metrodome (15-11) | 25-23 | |
| » W: Juan Berenguer (5-3) L: Dale Mohorcic (2-2) S: Jeff Reardon (13) | Second | 9 out |
| Wednesday, June 1 |
| » Defeated Rangers (25-25), 7-1 | Hubert H. Humphrey Metrodome (16-11) | 26-23 | Won 2 |
| » W: Frank Viola (9-1) L: Jose Guzman (5-4) | Second | 9 out |
| Friday, June 3 |
| » Lost to Athletics (37-15), 8-5 | Hubert H. Humphrey Metrodome (16-12) | 26-24 | |
| » W: Dave Stewart (9-3) L: Les Straker (2-3) S: Dennis Eckersley (18) | Second | 10 out |
| Saturday, June 4 |
| » Lost to Athletics (38-15), 6-4 | Hubert H. Humphrey Metrodome (16-13) | 26-25 | Lost 2 |
| » W: Storm Davis (5-2) L: Bert Blyleven (3-6) S: Dennis Eckersley (19) | Second | 11 out |
| Sunday, June 5 |
| » Defeated Athletics (38-16), 4-3 | Hubert H. Humphrey Metrodome (17-13) | 27-25 | |
| » W: Keith Atherton (4-1) L: Bob Welch (8-3) S: Jeff Reardon (14) | Second | 10 out |
| Monday, June 6 |
| » Defeated White Sox (23-31), 9-4 | Comiskey Park I (1-0) | 28-25 | Won 2 |
| » W: Juan Berenguer (6-3) L: Bill Long (1-2) | Second | 9 out |
| Tuesday, June 7 |
| » Lost to White Sox (24-31), 10-8 | Comiskey Park I (1-1) | 28-26 | |
| » W: Ricky Horton (4-6) L: Keith Atherton (4-2) S: Bobby Thigpen (10) | Second | 9 out |
| Wednesday, June 8 |
| » Defeated White Sox (24-32), 5-2 | Comiskey Park I (2-1) | 29-26 | |
| » W: Juan Berenguer (7-3) L: Dave LaPoint (4-6) | Second | 8 out |
| Thursday, June 9 |
| » Defeated Mariners (25-35), 7-5 | Kingdome (1-0) | 30-26 | Won 2 |
| » W: Bert Blyleven (4-6) L: Mark Langston (5-6) S: Jeff Reardon (15) | Second | 7 out |
| Friday, June 10 |
| » Defeated Mariners (25-36), 3-1 | Kingdome (2-0) | 31-26 | Won 3 |
| » W: Allan Anderson (3-3) L: Edwin Nunez (1-4) S: Jeff Reardon (16) | Second | 7 out |
| » Major-league debuts: Mike Schooler (Mariners) |
| Saturday, June 11 |
| » Lost to Mariners (26-36), 3-2 | Kingdome (2-1) | 31-27 | |
| » W: Mike Jackson (3-2) L: Frank Viola (9-2) S: Mike Schooler (1) | Second | 8 out |
| Sunday, June 12 |
| » Defeated Mariners (26-37), 6-2 | Kingdome (3-1) | 32-27 | |
| » W: Charlie Lea (2-3) L: Bill Swift (5-3) | Second | 7 out |
| Monday, June 13 |
| » Lost to White Sox (27-33), 4-1 | Hubert H. Humphrey Metrodome (17-14) | 32-28 | |
| » W: Melido Perez (6-2) L: Les Straker (2-4) S: Bobby Thigpen (12) | Second | 7½ out |
| Tuesday, June 14 |
| » Defeated White Sox (27-34), 3-1 | Hubert H. Humphrey Metrodome (18-14) | 33-28 | |
| » W: Bert Blyleven (5-6) L: Dave LaPoint (4-7) S: Jeff Reardon (17) | Second | 6½ out |
| Wednesday, June 15 |
| » Defeated White Sox (27-35), 5-1 | Hubert H. Humphrey Metrodome (19-14) | 34-28 | Won 2 |
| » W: Allan Anderson (4-3) L: Jack McDowell (2-6) S: Keith Atherton (2) | Second | 5½ out |
| Friday, June 17 |
| » Defeated Mariners (26-41), 4-1 | Hubert H. Humphrey Metrodome (20-14) | 35-28 | Won 3 |
| » W: Frank Viola (10-2) L: Scott Bankhead (1-3) S: Jeff Reardon (18) | Second | 5 out |
| Saturday, June 18 |
| » Defeated Mariners (26-42), 6-2 | Hubert H. Humphrey Metrodome (21-14) | 36-28 | Won 4 |
| » W: Charlie Lea (3-3) L: Bill Swift (5-4) S: Jeff Reardon (19) | Second | 5 out |
| Sunday, June 19 |
| » Defeated Mariners (26-43), 3-1 | Hubert H. Humphrey Metrodome (22-14) | 37-28 | Won 5 |
| » W: Bert Blyleven (6-6) L: Mike Moore (3-8) S: Jeff Reardon (20) | Second | 4 out |
| Monday, June 20 |
| » Lost to Angels (29-40), 6-5 | Hubert H. Humphrey Metrodome (22-15) | 37-29 | |
| » W: Donnie Moore (3-2) L: Allan Anderson (4-4) | Second | 5 out |
| Tuesday, June 21 |
| » Lost to Angels (30-40), 5-4 | Hubert H. Humphrey Metrodome (22-16) | 37-30 | Lost 2 |
| » W: Greg Minton (2-1) L: Mark Portugal (0-1) S: Bryan Harvey (6) | Second | 6 out |
| Wednesday, June 22 |
| » Defeated Angels (30-41), 3-1 | Hubert H. Humphrey Metrodome (23-16) | 38-30 | |
| » W: Frank Viola (11-2) L: Willie Fraser (4-7) | Second | 6 out |
| Friday, June 24 |
| » Defeated Athletics (45-26), 11-5 | Oakland-Alameda County Stadium (1-0) | 39-30 | Won 2 |
| » W: Keith Atherton (5-2) L: Gene Nelson (5-3) | Second | 5 out |
| Saturday, June 25 |
| » Lost to Athletics (46-26), 4-3 | Oakland-Alameda County Stadium (1-1) | 39-31 | |
| » W: Bob Welch (9-4) L: Allan Anderson (4-5) S: Dennis Eckersley (23) | Second | 6 out |
| » Major-league debuts: Kelvin Torve (Twins) |
| Sunday, June 26 |
| » Defeated Athletics (46-27), 11-0 | Oakland-Alameda County Stadium (2-1) | 40-31 | |
| » W: Charlie Lea (4-3) L: Curt Young (5-5) S: Juan Berenguer (1) | Second | 4 out |
| » Defeated Athletics (46-28), 5-0 | Oakland-Alameda County Stadium (3-1) | 41-31 | Won 2 |
| » W: Frank Viola (12-2) L: Dave Stewart (10-6) S: Keith Atherton (3) | Second | 4 out |
| Monday, June 27 |
| » Lost to Angels (33-42), 16-7 | Anaheim Stadium (0-1) | 41-32 | |
| » W: Kirk McCaskill (4-5) L: Freddie Toliver (0-1) | Second | 5 out |
| Tuesday, June 28 |
| » Defeated Angels (33-43), 8-2 | Anaheim Stadium (1-1) | 42-32 | |
| » W: Bert Blyleven (7-6) L: Jack Lazorko (0-1) | Second | 4 out |
| Wednesday, June 29 |
| » Lost to Angels (34-43), 2-1 | Anaheim Stadium (1-2) | 42-33 | |
| » W: Chuck Finley (5-8) L: Allan Anderson (4-6) S: Bryan Harvey (8) | Second | 5 out |
| Friday, July 1 |
| » Defeated Brewers (38-40), 5-4 | County Stadium (1-2) | 43-33 | |
| » W: Frank Viola (13-2) L: Tom Filer (4-3) S: Jeff Reardon (21) | Second | 5 out |
| Saturday, July 2 |
| » Defeated Brewers (38-41), 8-2 | County Stadium (2-2) | 44-33 | Won 2 |
| » W: Charlie Lea (5-3) L: Chris Bosio (6-9) | Second | 5 out |
| Sunday, July 3 |
| » Lost to Brewers (39-41), 4-3 | County Stadium (2-3) | 44-34 | |
| » W: Bill Wegman (7-6) L: Keith Atherton (5-3) S: Dan Plesac (17) | Second | 6 out |
| Monday, July 4 |
| » Defeated Brewers (39-42), 3-1 | County Stadium (3-3) | 45-34 | |
| » W: Allan Anderson (5-6) L: Don August (4-3) S: Jeff Reardon (22) | Second | 6 out |
| Tuesday, July 5 |
| » Defeated Red Sox (40-38), 6-4 | Hubert H. Humphrey Metrodome (24-16) | 46-34 | Won 2 |
| » W: Juan Berenguer (8-3) L: Lee Smith (2-4) S: Jeff Reardon (23) | Second | 4½ out |
| Wednesday, July 6 |
| » Defeated Red Sox (40-39), 8-1 | Hubert H. Humphrey Metrodome (25-16) | 47-34 | Won 3 |
| » W: Frank Viola (14-2) L: Bruce Hurst (9-4) | Second | 3½ out |
| Thursday, July 7 |
| » Lost to Red Sox (41-39), 4-3 | Hubert H. Humphrey Metrodome (25-17) | 47-35 | |
| » W: Oil Can Boyd (7-7) L: Charlie Lea (5-4) S: Bob Stanley (1) | Second | 3½ out |
| Friday, July 8 |
| » Lost to Brewers (42-43), 5-3 | Hubert H. Humphrey Metrodome (25-18) | 47-36 | Lost 2 |
| » W: Bill Wegman (8-6) L: Bert Blyleven (7-7) S: Dan Plesac (20) | Second | 4½ out |
| Saturday, July 9 |
| » Lost to Brewers (43-43), 5-4 | Hubert H. Humphrey Metrodome (25-19) | 47-37 | Lost 3 |
| » W: Chuck Crim (1-4) L: Jeff Reardon (0-3) S: Dan Plesac (21) | Second | 4½ out |
| Sunday, July 10 |
| » Lost to Brewers (44-43), 3-2 | Hubert H. Humphrey Metrodome (25-20) | 47-38 | Lost 4 |
| » W: Chuck Crim (2-4) L: Keith Atherton (5-4) S: Dan Plesac (22) | Second | 5½ out |
| Thursday, July 14 |
| » Lost to Orioles (29-59), 7-1 | Memorial Stadium (0-2) | 47-39 | Lost 5 |
| » W: Mike Boddicker (5-11) L: Bert Blyleven (7-8) | Second | 5 out |
| » Defeated Orioles (29-60), 8-2 | Memorial Stadium (1-2) | 48-39 | |
| » W: Allan Anderson (6-6) L: Jay Tibbs (4-6) | Second | 5 out |
| Friday, July 15 |
| » Defeated Orioles (29-61), 4-2 | Memorial Stadium (2-2) | 49-39 | Won 2 |
| » W: Charlie Lea (6-4) L: Jeff Ballard (4-7) S: Jeff Reardon (24) | Second | 4 out |
| Saturday, July 16 |
| » Defeated Orioles (29-62), 4-3 | Memorial Stadium (3-2) | 50-39 | Won 3 |
| » W: Freddie Toliver (1-1) L: Oswaldo Peraza (2-4) S: Jeff Reardon (25) | Second | 4 out |
| Sunday, July 17 |
| » Defeated Orioles (29-63), 7-2 | Memorial Stadium (4-2) | 51-39 | Won 4 |
| » W: Frank Viola (15-2) L: Jose Bautista (5-7) S: Mark Portugal (2) | Second | 3 out |
| Monday, July 18 |
| » Lost to Red Sox (48-42), 6-5 | Fenway Park (1-3) | 51-40 | |
| » W: Dennis Lamp (4-3) L: Bert Blyleven (7-9) S: Lee Smith (13) | Second | 4 out |
| Tuesday, July 19 |
| » Lost to Red Sox (49-42), 5-0 | Fenway Park (1-4) | 51-41 | Lost 2 |
| » W: Mike Smithson (5-3) L: Allan Anderson (6-7) | Second | 5½ out |
| Wednesday, July 20 |
| » Lost to Red Sox (50-42), 9-7 | Fenway Park (1-5) | 51-42 | Lost 3 |
| » W: Tom Bolton (1-1) L: Keith Atherton (5-5) | Second | 5½ out |
| Friday, July 22 |
| » Defeated Orioles (30-65), 6-1 | Hubert H. Humphrey Metrodome (26-20) | 52-42 | |
| » W: Frank Viola (16-2) L: Jeff Ballard (4-8) | Second | 5½ out |
| Saturday, July 23 |
| » Lost to Orioles (31-65), 11-8 | Hubert H. Humphrey Metrodome (26-21) | 52-43 | |
| » W: Mike Morgan (1-5) L: Bert Blyleven (7-10) S: Tom Niedenfuer (11) | Second | 6½ out |
| Sunday, July 24 |
| » Defeated Orioles (31-66), 6-1 | Hubert H. Humphrey Metrodome (27-21) | 53-43 | |
| » W: Allan Anderson (7-7) L: Mike Boddicker (6-12) | Second | 6½ out |
| Monday, July 25 |
| » Defeated Blue Jays (49-51), 5-4 | Hubert H. Humphrey Metrodome (28-21) | 54-43 | Won 2 |
| » W: Jim Winn (1-0) L: Tom Henke (1-3) | Second | 5½ out |
| Tuesday, July 26 |
| » Defeated Blue Jays (49-52), 6-3 | Hubert H. Humphrey Metrodome (29-21) | 55-43 | Won 3 |
| » W: Mark Portugal (1-1) L: Duane Ward (6-1) S: Jeff Reardon (26) | Second | 5½ out |
| Wednesday, July 27 |
| » Lost to Blue Jays (50-52), 4-1 | Hubert H. Humphrey Metrodome (29-22) | 55-44 | |
| » W: John Cerutti (5-6) L: Frank Viola (16-3) S: Tom Henke (18) | Second | 5½ out |
| Friday, July 29 |
| » Lost to Indians (52-51), 7-0 | Cleveland Stadium (1-3) | 55-45 | Lost 2 |
| » W: Greg Swindell (12-9) L: Bert Blyleven (7-11) | Second | 5½ out |
| Saturday, July 30 |
| » Defeated Indians (52-52), 4-2 | Cleveland Stadium (2-3) | 56-45 | |
| » W: Allan Anderson (8-7) L: Rod Nichols (0-1) | Second | 5½ out |
| » Major-league debuts: Rod Nichols (Indians) |
| Sunday, July 31 |
| » Defeated Indians (52-53), 12-4 | Cleveland Stadium (3-3) | 57-45 | Won 2 |
| » W: Freddie Toliver (2-1) L: John Farrell (11-7) S: Mark Portugal (3) | Second | 5½ out |
| Monday, August 1 |
| » Lost to Blue Jays (52-54), 3-1 | Exhibition Stadium (1-2) | 57-46 | |
| » W: Dave Stieb (11-7) L: Frank Viola (16-4) S: Tom Henke (19) | Second | 6½ out |
| Tuesday, August 2 |
| » Lost to Blue Jays (53-54), 11-1 | Exhibition Stadium (1-3) | 57-47 | Lost 2 |
| » W: Jim Clancy (5-11) L: Charlie Lea (6-5) | Second | 6½ out |
| Wednesday, August 3 |
| » Defeated Blue Jays (53-55), 8-3 | Exhibition Stadium (2-3) | 58-47 | |
| » W: Keith Atherton (6-5) L: Jeff Musselman (3-1) S: Jeff Reardon (27) | Second | 6½ out |
| Thursday, August 4 |
| » Defeated Blue Jays (53-56), 2-1 | Exhibition Stadium (3-3) | 59-47 | Won 2 |
| » W: Allan Anderson (9-7) L: Mike Flanagan (10-8) | Second | 6½ out |
| Friday, August 5 |
| » Defeated Yankees (60-45), 7-5 | Yankee Stadium (1-2) | 60-47 | Won 3 |
| » W: Freddie Toliver (3-1) L: Rick Rhoden (7-7) S: Jeff Reardon (28) | Second | 6 out |
| » Defeated Yankees (60-46), 11-2 | Yankee Stadium (2-2) | 61-47 | Won 4 |
| » W: Frank Viola (17-4) L: Lee Guetterman (0-1) | Second | 6 out |
| Saturday, August 6 |
| » Lost to Yankees (61-46), 5-3 | Yankee Stadium (2-3) | 61-48 | |
| » W: Steve Shields (2-3) L: Mark Portugal (1-2) S: Dave Righetti (17) | Second | 7 out |
| Sunday, August 7 |
| » Lost to Yankees (62-46), 5-1 | Yankee Stadium (2-4) | 61-49 | Lost 2 |
| » W: Richard Dotson (9-4) L: Charlie Lea (6-6) | Second | 7 out |
| Monday, August 8 |
| » Defeated Indians (53-59), 7-2 | Hubert H. Humphrey Metrodome (30-22) | 62-49 | |
| » W: Allan Anderson (10-7) L: Chris Codiroli (0-3) S: Jeff Reardon (29) | Second | 7 out |
| Tuesday, August 9 |
| » Defeated Indians (53-60), 4-3 | Hubert H. Humphrey Metrodome (31-22) | 63-49 | Won 2 |
| » W: Freddie Toliver (4-1) L: Greg Swindell (12-11) S: Jeff Reardon (30) | Second | 7 out |
| Wednesday, August 10 |
| » Defeated Indians (53-61), 10-4 | Hubert H. Humphrey Metrodome (32-22) | 64-49 | Won 3 |
| » W: Frank Viola (18-4) L: Rod Nichols (0-3) | Second | 7 out |
| Friday, August 12 |
| » Lost to Yankees (63-49), 6-4 | Hubert H. Humphrey Metrodome (32-23) | 64-50 | |
| » W: Steve Shields (3-3) L: Jeff Reardon (0-4) S: Dave Righetti (18) | Second | 8½ out |
| Saturday, August 13 |
| » Defeated Yankees (63-50), 12-2 | Hubert H. Humphrey Metrodome (33-23) | 65-50 | |
| » W: Roy Smith (1-0) L: Richard Dotson (9-5) | Second | 8½ out |
| Sunday, August 14 |
| » Lost to Yankees (64-50), 9-6 | Hubert H. Humphrey Metrodome (33-24) | 65-51 | |
| » W: John Candelaria (13-7) L: Freddie Toliver (4-2) | Second | 8½ out |
| Monday, August 15 |
| » Defeated Tigers (69-48), 2-1 | Tiger Stadium (3-1) | 66-51 | |
| » W: Frank Viola (19-4) L: Walt Terrell (6-10) | Second | 8 out |
| Tuesday, August 16 |
| » Defeated Tigers (69-49), 4-1 | Tiger Stadium (4-1) | 67-51 | Won 2 |
| » W: Bert Blyleven (8-11) L: Jack Morris (10-12) S: Jeff Reardon (31) | Second | 8 out |
| Wednesday, August 17 |
| » Defeated Tigers (69-50), 2-1 | Tiger Stadium (5-1) | 68-51 | Won 3 |
| » W: Allan Anderson (11-7) L: Doyle Alexander (11-8) S: Jeff Reardon (32) | Second | 8 out |
| Thursday, August 18 |
| » Lost to Rangers (53-66), 4-2 | Hubert H. Humphrey Metrodome (33-25) | 68-52 | |
| » W: Jeff Russell (10-5) L: Charlie Lea (6-7) | Second | 8 out |
| Friday, August 19 |
| » Lost to Rangers (54-66), 5-0 | Hubert H. Humphrey Metrodome (33-26) | 68-53 | Lost 2 |
| » W: Bobby Witt (5-8) L: Freddie Toliver (4-3) | Second | 8 out |
| Saturday, August 20 |
| » Lost to Rangers (55-66), 3-2 | Hubert H. Humphrey Metrodome (33-27) | 68-54 | Lost 3 |
| » W: Paul Kilgus (10-11) L: Frank Viola (19-5) S: Mitch Williams (16) | Second | 8 out |
| Sunday, August 21 |
| » Defeated Rangers (55-67), 12-2 | Hubert H. Humphrey Metrodome (34-27) | 69-54 | |
| » W: Bert Blyleven (9-11) L: Charlie Hough (10-14) | Second | 8 out |
| Monday, August 22 |
| » Defeated Tigers (73-51), 7-0 | Hubert H. Humphrey Metrodome (35-27) | 70-54 | Won 2 |
| » W: Allan Anderson (12-7) L: Doyle Alexander (11-9) | Second | 8 out |
| Tuesday, August 23 |
| » Defeated Tigers (73-52), 7-5 | Hubert H. Humphrey Metrodome (36-27) | 71-54 | Won 3 |
| » W: Jeff Reardon (1-4) L: Mike Henneman (6-3) | Second | 7 out |
| Wednesday, August 24 |
| » Defeated Tigers (73-53), 8-2 | Hubert H. Humphrey Metrodome (37-27) | 72-54 | Won 4 |
| » W: Freddie Toliver (5-3) L: Frank Tanana (14-8) | Second | 6 out |
| Friday, August 26 |
| » Lost to Royals (66-61), 4-3 | Royals Stadium (3-1) | 72-55 | |
| » W: Charlie Leibrandt (9-11) L: Frank Viola (19-6) | Second | 7 out |
| Saturday, August 27 |
| » Lost to Royals (67-61), 4-1 | Royals Stadium (3-2) | 72-56 | Lost 2 |
| » W: Mark Gubicza (16-7) L: Bert Blyleven (9-12) | Second | 8 out |
| Sunday, August 28 |
| » Lost to Royals (68-61), 12-3 | Royals Stadium (3-3) | 72-57 | Lost 3 |
| » W: Jeff Montgomery (7-2) L: Allan Anderson (12-8) | Second | 8 out |
| Monday, August 29 |
| » Defeated Rangers (59-70), 3-2 | Arlington Stadium (3-1) | 73-57 | |
| » W: Freddie Toliver (6-3) L: Jeff Russell (10-6) S: Jeff Reardon (33) | Second | 8 out |
| Tuesday, August 30 |
| » Lost to Rangers (60-70), 8-6 | Arlington Stadium (3-2) | 73-58 | |
| » W: Ed Vande Berg (1-1) L: Juan Berenguer (8-4) | Second | 9 out |
| Wednesday, August 31 |
| » Defeated Rangers (60-71), 10-1 | Arlington Stadium (4-2) | 74-58 | |
| » W: Frank Viola (20-6) L: Paul Kilgus (11-12) | Second | 9 out |
| Thursday, September 1 |
| » Lost to Royals (71-62), 5-2 | Hubert H. Humphrey Metrodome (37-28) | 74-59 | |
| » W: Mark Gubicza (17-7) L: Bert Blyleven (9-13) | Second | 9½ out |
| Friday, September 2 |
| » Defeated Royals (71-63), 6-3 | Hubert H. Humphrey Metrodome (38-28) | 75-59 | |
| » W: Allan Anderson (13-8) L: Floyd Bannister (9-12) S: Jeff Reardon (34) | Second | 8½ out |
| Saturday, September 3 |
| » Defeated Royals (71-64), 8-6 | Hubert H. Humphrey Metrodome (39-28) | 76-59 | Won 2 |
| » W: Mark Portugal (2-2) L: Jerry Don Gleaton (0-3) S: Jeff Reardon (35) | Second | 8½ out |
| Sunday, September 4 |
| » Lost to Royals (72-64), 3-2 | Hubert H. Humphrey Metrodome (39-29) | 76-60 | |
| » W: Israel Sanchez (2-1) L: Les Straker (2-5) S: Steve Farr (17) | Second | 9½ out |
| Monday, September 5 |
| » Defeated Mariners (55-83), 2-0 | Hubert H. Humphrey Metrodome (40-29) | 77-60 | |
| » W: Frank Viola (21-6) L: Erik Hanson (0-1) S: Jeff Reardon (36) | Second | 9½ out |
| » Major-league debuts: Erik Hanson (Mariners) |
| Tuesday, September 6 |
| » Lost to Mariners (56-83), 8-3 | Hubert H. Humphrey Metrodome (40-30) | 77-61 | |
| » W: Mike Campbell (6-8) L: Bert Blyleven (9-14) S: Mike Schooler (11) | Second | 9½ out |
| Wednesday, September 7 |
| » Lost to Mariners (57-83), 2-1 | Hubert H. Humphrey Metrodome (40-31) | 77-62 | Lost 2 |
| » W: Bill Swift (7-10) L: Dan Schatzeder (0-3) | Second | 10½ out |
| Friday, September 9 |
| » Defeated White Sox (60-79), 1-0 | Comiskey Park I (3-1) | 78-62 | |
| » W: Freddie Toliver (7-3) L: Bill Long (7-10) S: Jeff Reardon (37) | Second | 11 out |
| Saturday, September 10 |
| » Defeated White Sox (60-80), 6-5 | Comiskey Park I (4-1) | 79-62 | Won 2 |
| » W: Mark Portugal (3-2) L: Steve Rosenberg (0-1) S: German Gonzalez (1) | Second | 10 out |
| Sunday, September 11 |
| » Lost to White Sox (61-80), 3-2 | Comiskey Park I (4-2) | 79-63 | |
| » W: Shawn Hillegas (4-5) L: Bert Blyleven (9-15) S: Ken Patterson (1) | Second | 11 out |
| Monday, September 12 |
| » Lost to Mariners (59-85), 3-1 | Kingdome (3-2) | 79-64 | Lost 2 |
| » W: Mike Moore (8-14) L: Allan Anderson (13-9) | Second | 11½ out |
| Tuesday, September 13 |
| » Defeated Mariners (59-86), 2-1 | Kingdome (4-2) | 80-64 | |
| » W: Keith Atherton (7-5) L: Bill Swift (7-11) S: Jeff Reardon (38) | Second | 11½ out |
| Wednesday, September 14 |
| » Lost to Mariners (60-86), 2-0 | Kingdome (4-3) | 80-65 | |
| » W: Mark Langston (12-11) L: Freddie Toliver (7-4) S: Mike Schooler (13) | Second | 11½ out |
| Thursday, September 15 |
| » Defeated White Sox (62-83), 10-3 | Hubert H. Humphrey Metrodome (41-31) | 81-65 | |
| » W: Frank Viola (22-6) L: Melido Perez (11-9) | Second | 11½ out |
| Friday, September 16 |
| » Defeated White Sox (62-84), 5-4 | Hubert H. Humphrey Metrodome (42-31) | 82-65 | Won 2 |
| » W: Bert Blyleven (10-15) L: Shawn Hillegas (4-6) S: Jeff Reardon (39) | Second | 10½ out |
| Saturday, September 17 |
| » Defeated White Sox (62-85), 3-1 | Hubert H. Humphrey Metrodome (43-31) | 83-65 | Won 3 |
| » W: Allan Anderson (14-9) L: Jerry Reuss (11-9) S: Jeff Reardon (40) | Second | 10½ out |
| Sunday, September 18 |
| » Lost to White Sox (63-85), 8-5 | Hubert H. Humphrey Metrodome (43-32) | 83-66 | |
| » W: Tom McCarthy (1-0) L: Mark Portugal (3-3) S: Bobby Thigpen (31) | Second | 11½ out |
| Monday, September 19 |
| » Lost to Athletics (96-55), 5-3 | Oakland-Alameda County Stadium (3-2) | 83-67 | Lost 2 |
| » W: Dave Stewart (19-12) L: Freddie Toliver (7-5) S: Dennis Eckersley (42) | Second | 12½ out |
| Tuesday, September 20 |
|