| Saturday, January 23 |
| Former Pirate Johnny Gee dies in Cortland, NY at the age of 73. |
| Monday, March 14 |
| Former Pirate Zeb Terry dies in Los Angeles, CA at the age of 97. |
| Tuesday, March 29 |
| Former Pirate Ted Kluszewski dies in Cincinnati, OH at the age of 64. |
| Tuesday, April 5 |
| » Defeated Phillies (0-1), 5-3 | Veteran's Stadium (1-0) | 1-0 | |
| » W: Mike Dunne (1-0) L: Shane Rawley (0-1) S: Jeff Robinson (1) | First | -- |
| Wednesday, April 6 |
| » Lost to Phillies (1-1), 6-5 | Veteran's Stadium (1-1) | 1-1 | |
| » W: Mike Maddux (1-0) L: Bob Kipper (0-1) | Second | 1 out |
| Friday, April 8 |
| » Defeated Cardinals (0-3), 4-3 | Busch Stadium II (1-0) | 2-1 | |
| » W: Brian Fisher (1-0) L: Danny Cox (0-1) S: Jeff Robinson (2) | Second | 1 out |
| Saturday, April 9 |
| » Lost to Cardinals (1-3), 3-0 | Busch Stadium II (1-1) | 2-2 | |
| » W: Greg Mathews (1-0) L: Bob Walk (0-1) S: Todd Worrell (1) | Second | 1 out |
| Sunday, April 10 |
| » Defeated Cardinals (1-4), 5-3 | Busch Stadium II (2-1) | 3-2 | |
| » W: Bob Kipper (1-1) L: Todd Worrell (0-1) S: Jim Gott (1) | Second | 1 out |
| Monday, April 11 |
| » Defeated Phillies (3-3), 5-1 | Three Rivers Stadium (1-0) | 4-2 | Won 2 |
| » W: Doug Drabek (1-0) L: Kevin Gross (0-1) | Second | 1 out |
| Wednesday, April 13 |
| » Defeated Phillies (3-4), 7-0 | Three Rivers Stadium (2-0) | 5-2 | Won 3 |
| » W: Brian Fisher (2-0) L: Bruce Ruffin (1-1) | First | -- |
| Thursday, April 14 |
| » Defeated Phillies (3-5), 4-2 | Three Rivers Stadium (3-0) | 6-2 | Won 4 |
| » W: Bob Walk (1-1) L: Don Carman (1-1) S: Jeff Robinson (3) | First | -- |
| Friday, April 15 |
| » Lost to Cubs (6-3), 6-0 | Wrigley Field (0-1) | 6-3 | |
| » W: Rick Sutcliffe (1-0) L: John Smiley (0-1) | First | -- |
| Saturday, April 16 |
| » Defeated Cubs (6-4), 4-0 | Wrigley Field (1-1) | 7-3 | |
| » W: Doug Drabek (2-0) L: Greg Maddux (2-1) | First | -- |
| Sunday, April 17 |
| » Defeated Cubs (6-5), 12-7 | Wrigley Field (2-1) | 8-3 | Won 2 |
| » W: Jeff Robinson (1-0) L: Calvin Schiraldi (0-2) | First | -- |
| Tuesday, April 19 |
| » Defeated Cardinals (3-9), 3-0 | Three Rivers Stadium (4-0) | 9-3 | Won 3 |
| » W: Brian Fisher (3-0) L: Danny Cox (1-2) | First | -- |
| Wednesday, April 20 |
| » Defeated Cardinals (3-10), 8-1 | Three Rivers Stadium (5-0) | 10-3 | Won 4 |
| » W: Bob Walk (2-1) L: Greg Mathews (1-2) | First | -- |
| Thursday, April 21 |
| » Lost to Cardinals (4-10), 9-3 | Three Rivers Stadium (5-1) | 10-4 | |
| » W: Randy O'Neal (1-0) L: John Smiley (0-2) | First | -- |
| Friday, April 22 |
| » Defeated Cubs (7-8), 8-4 | Three Rivers Stadium (6-1) | 11-4 | |
| » W: Doug Drabek (3-0) L: Les Lancaster (0-2) | First | -- |
| Saturday, April 23 |
| » Defeated Cubs (7-9), 5-4 | Three Rivers Stadium (7-1) | 12-4 | Won 2 |
| » W: Jim Gott (1-0) L: Rich Gossage (1-1) | First | -- |
| Sunday, April 24 |
| » Defeated Cubs (7-10), 4-2 | Three Rivers Stadium (8-1) | 13-4 | Won 3 |
| » W: Bob Walk (3-1) L: Rick Sutcliffe (1-2) S: Jeff Robinson (4) | First | -- |
| Tuesday, April 26 |
| » Defeated Giants (9-10), 2-0 | Candlestick Park (1-0) | 14-4 | Won 4 |
| » W: John Smiley (1-2) L: Rick Reuschel (3-1) S: Jim Gott (2) | First | -- |
| Wednesday, April 27 |
| » Lost to Giants (10-10), 6-4 | Candlestick Park (1-1) | 14-5 | |
| » W: Dave Dravecky (2-1) L: Doug Drabek (3-1) S: Joe Price (2) | First | -- |
| Thursday, April 28 |
| » Defeated Giants (10-11), 2-1 | Candlestick Park (2-1) | 15-5 | |
| » W: Jeff Robinson (2-0) L: Craig Lefferts (1-1) S: Jim Gott (3) | First | -- |
| Friday, April 29 |
| » Lost to Padres (9-11), 6-3 | San Diego/Jack Murphy Stadium (0-1) | 15-6 | |
| » W: Andy Hawkins (3-1) L: Vicente Palacios (0-1) S: Mark Davis (3) | First | -- |
| Saturday, April 30 |
| » Defeated Padres (9-12), 5-1 | San Diego/Jack Murphy Stadium (1-1) | 16-6 | |
| » W: Bob Walk (4-1) L: Mark Grant (0-3) | First | -- |
| Sunday, May 1 |
| » Defeated Padres (9-13), 4-2 | San Diego/Jack Murphy Stadium (2-1) | 17-6 | Won 2 |
| » W: John Smiley (2-2) L: Eric Show (1-4) S: Jim Gott (4) | First | -- |
| Monday, May 2 |
| » Lost to Dodgers (14-8), 6-3 | Dodger Stadium (0-1) | 17-7 | |
| » W: Jesse Orosco (1-0) L: Doug Drabek (3-2) | First | -- |
| Tuesday, May 3 |
| » Lost to Dodgers (15-8), 14-6 | Dodger Stadium (0-2) | 17-8 | Lost 2 |
| » W: Tim Belcher (2-1) L: Mike Dunne (1-1) | Second | ½ out |
| Wednesday, May 4 |
| » Lost to Dodgers (16-8), 8-5 | Dodger Stadium (0-3) | 17-9 | Lost 3 |
| » W: Orel Hershiser (6-0) L: Vicente Palacios (0-2) | Second | 1½ out |
| Friday, May 6 |
| » Defeated Padres (9-17), 4-1 | Three Rivers Stadium (9-1) | 18-9 | |
| » W: Barry Jones (1-0) L: Mark Davis (1-1) | Second | 1½ out |
| Saturday, May 7 |
| » Lost to Padres (10-17), 3-2 | Three Rivers Stadium (9-2) | 18-10 | |
| » W: Eric Show (2-4) L: Jim Gott (1-1) | Second | 2½ out |
| Sunday, May 8 |
| » Defeated Padres (10-18), 6-2 | Three Rivers Stadium (10-2) | 19-10 | |
| » W: Doug Drabek (4-2) L: Jimmy Jones (2-4) | Second | 2½ out |
| Monday, May 9 |
| » Lost to Giants (15-16), 8-6 | Three Rivers Stadium (10-3) | 19-11 | |
| » W: Don Robinson (2-1) L: Jeff Robinson (2-1) S: Craig Lefferts (2) | Second | 2½ out |
| Tuesday, May 10 |
| » Defeated Giants (15-17), 6-2 | Three Rivers Stadium (11-3) | 20-11 | |
| » W: Vicente Palacios (1-2) L: Kelly Downs (0-3) S: Jim Gott (5) | Second | 2½ out |
| Wednesday, May 11 |
| » Defeated Dodgers (19-10), 2-1 | Three Rivers Stadium (12-3) | 21-11 | Won 2 |
| » W: Scott Medvin (1-0) L: Alejandro Pena (1-1) | Second | 2½ out |
| » Major-league debuts: Scott Medvin (Pirates) |
| Thursday, May 12 |
| » Defeated Dodgers (19-11), 7-4 | Three Rivers Stadium (13-3) | 22-11 | Won 3 |
| » W: John Smiley (3-2) L: Orel Hershiser (6-1) | Second | 2 out |
| Former Pirate Hank Schenz dies in Cincinnati, OH at the age of 70. |
| Friday, May 13 |
| » Defeated Reds (16-18), 6-5 | Three Rivers Stadium (14-3) | 23-11 | Won 4 |
| » W: Jeff Robinson (3-1) L: Rob Murphy (0-3) | Second | 1 out |
| Saturday, May 14 |
| » Lost to Reds (17-18), 5-3 | Three Rivers Stadium (14-4) | 23-12 | |
| » W: Mario Soto (2-2) L: Mike Dunne (1-2) S: John Franco (5) | Second | 1 out |
| Sunday, May 15 |
| » Lost to Reds (18-18), 7-6 | Three Rivers Stadium (14-5) | 23-13 | Lost 2 |
| » W: John Franco (1-3) L: Barry Jones (1-1) | Second | 1 out |
| Monday, May 16 |
| » Lost to Astros (20-15), 9-2 | Astrodome (0-1) | 23-14 | Lost 3 |
| » W: Jim Deshaies (3-2) L: Bob Walk (4-2) | Second | 2 out |
| Tuesday, May 17 |
| » Lost to Astros (21-15), 3-2 | Astrodome (0-2) | 23-15 | Lost 4 |
| » W: Mike Scott (5-0) L: John Smiley (3-3) S: Dave Smith (7) | Second | 3 out |
| Wednesday, May 18 |
| » Lost to Astros (22-15), 4-2 | Astrodome (0-3) | 23-16 | Lost 5 |
| » W: Nolan Ryan (4-2) L: Doug Drabek (4-3) S: Dave Smith (8) | Second | 4 out |
| Friday, May 20 |
| » Defeated Braves (11-26), 10-3 | Three Rivers Stadium (15-5) | 24-16 | |
| » W: Mike Dunne (2-2) L: Tom Glavine (1-6) | Second | 4½ out |
| Saturday, May 21 |
| » Defeated Braves (11-27), 7-3 | Three Rivers Stadium (16-5) | 25-16 | Won 2 |
| » W: Brian Fisher (4-0) L: Kevin Coffman (2-4) | Second | 4½ out |
| Sunday, May 22 |
| » Lost to Braves (12-27), 6-4 | Three Rivers Stadium (16-6) | 25-17 | |
| » W: Rick Mahler (4-4) L: Bob Walk (4-3) S: Bruce Sutter (4) | Second | 5½ out |
| Monday, May 23 |
| » Lost to Astros (25-16), 3-0 | Three Rivers Stadium (16-7) | 25-18 | Lost 2 |
| » W: Mike Scott (6-0) L: John Smiley (3-4) | Second | 6 out |
| Tuesday, May 24 |
| » Defeated Astros (25-17), 5-4 | Three Rivers Stadium (17-7) | 26-18 | |
| » W: Jim Gott (2-1) L: Larry Andersen (1-2) | Second | 5 out |
| Wednesday, May 25 |
| » Defeated Astros (25-18), 4-3 | Three Rivers Stadium (18-7) | 27-18 | Won 2 |
| » W: Mike Dunne (3-2) L: Joaquin Andujar (0-2) S: Jeff Robinson (5) | Second | 5 out |
| Friday, May 27 |
| » Lost to Reds (23-23), 5-3 | Riverfront Stadium (0-1) | 27-19 | |
| » W: Pat Pacillo (1-0) L: Brian Fisher (4-1) S: John Franco (6) | Second | 4½ out |
| Saturday, May 28 |
| » Defeated Reds (23-24), 5-2 | Riverfront Stadium (1-1) | 28-19 | |
| » W: Bob Walk (5-3) L: Tom Browning (2-2) S: Jeff Robinson (6) | Second | 4½ out |
| Sunday, May 29 |
| » Defeated Reds (23-25), 4-2 | Riverfront Stadium (2-1) | 29-19 | Won 2 |
| » W: John Smiley (4-4) L: Dennis Rasmussen (2-5) S: Jim Gott (6) | Second | 3½ out |
| Monday, May 30 |
| » Defeated Braves (15-31), 14-2 | Atlanta-Fulton County Stadium (1-0) | 30-19 | Won 3 |
| » W: Doug Drabek (5-3) L: Pete Smith (1-5) | Second | 3½ out |
| Tuesday, May 31 |
| » Lost to Braves (16-31), 11-1 | Atlanta-Fulton County Stadium (1-1) | 30-20 | |
| » W: Tom Glavine (2-6) L: Mike Dunne (3-3) | Second | 4½ out |
| Wednesday, June 1 |
| » Lost to Braves (17-31), 14-2 | Atlanta-Fulton County Stadium (1-2) | 30-21 | Lost 2 |
| » W: Rick Mahler (7-4) L: Brian Fisher (4-2) | Second | 4½ out |
| Thursday, June 2 |
| » Lost to Expos (24-26), 7-3 | Three Rivers Stadium (18-8) | 30-22 | Lost 3 |
| » W: Neal Heaton (2-3) L: Bob Walk (5-4) S: Joe Hesketh (1) | Second | 5½ out |
| Friday, June 3 |
| » Defeated Expos (24-27), 2-1 | Three Rivers Stadium (19-8) | 31-22 | |
| » W: John Smiley (5-4) L: John Dopson (1-3) | Second | 4½ out |
| Saturday, June 4 |
| » Lost to Expos (25-27), 7-3 | Three Rivers Stadium (19-9) | 31-23 | |
| » W: Dennis Martinez (5-6) L: Doug Drabek (5-4) S: Bob McClure (1) | Second | 5½ out |
| Sunday, June 5 |
| » Lost to Expos (26-27), 3-2 | Three Rivers Stadium (19-10) | 31-24 | Lost 2 |
| » W: Bryn Smith (4-4) L: Mike Dunne (3-4) S: Jeff Parrett (3) | Second | 6½ out |
| Tuesday, June 7 |
| » Lost to Cubs (28-27), 8-5 | Three Rivers Stadium (19-11) | 31-25 | Lost 3 |
| » W: Greg Maddux (10-3) L: Brian Fisher (4-3) S: Rich Gossage (7) | Second | 7 out |
| Wednesday, June 8 |
| » Defeated Cubs (28-28), 5-1 | Three Rivers Stadium (20-11) | 32-25 | |
| » W: Bob Walk (6-4) L: Calvin Schiraldi (3-3) | Second | 6 out |
| Thursday, June 9 |
| » Defeated Cubs (28-29), 4-3 | Three Rivers Stadium (21-11) | 33-25 | Won 2 |
| » W: Jim Gott (3-1) L: Frank DiPino (0-3) | Second | 5½ out |
| Friday, June 10 |
| » Lost to Phillies (24-32), 12-10 | Three Rivers Stadium (21-12) | 33-26 | |
| » W: Greg Harris (3-2) L: Jeff Robinson (3-2) S: Steve Bedrosian (6) | Second | 5½ out |
| Saturday, June 11 |
| » Defeated Phillies (24-33), 8-2 | Three Rivers Stadium (22-12) | 34-26 | |
| » W: Mike Dunne (4-4) L: David Palmer (1-6) | Second | 4½ out |
| Sunday, June 12 |
| » Lost to Phillies (25-33), 5-4 | Three Rivers Stadium (22-13) | 34-27 | |
| » W: Kevin Gross (7-2) L: Brian Fisher (4-4) S: Steve Bedrosian (7) | Second | 4½ out |
| Monday, June 13 |
| » Defeated Cubs (31-30), 8-0 | Wrigley Field (3-1) | 35-27 | |
| » W: Bob Walk (7-4) L: Calvin Schiraldi (3-4) | Second | 4½ out |
| Tuesday, June 14 |
| » Defeated Cubs (31-31), 6-3 | Wrigley Field (4-1) | 36-27 | Won 2 |
| » W: John Smiley (6-4) L: Jamie Moyer (3-7) S: Jeff Robinson (7) | Second | 4½ out |
| Wednesday, June 15 |
| » Lost to Cubs (32-31), 7-4 | Wrigley Field (4-2) | 36-28 | |
| » W: Pat Perry (3-2) L: Jim Gott (3-2) S: Rich Gossage (9) | Second | 5½ out |
| Friday, June 17 |
| » Lost to Cardinals (33-32), 7-3 | Three Rivers Stadium (22-14) | 36-29 | Lost 2 |
| » W: Joe Magrane (1-1) L: Mike Dunne (4-5) | Second | 5½ out |
| Saturday, June 18 |
| » Lost to Cardinals (34-32), 6-3 | Three Rivers Stadium (22-15) | 36-30 | Lost 3 |
| » W: John Tudor (3-2) L: Brian Fisher (4-5) S: Scott Terry (2) | Second | 6½ out |
| Sunday, June 19 |
| » Defeated Cardinals (34-33), 3-2 | Three Rivers Stadium (23-15) | 37-30 | |
| » W: Bob Walk (8-4) L: Larry McWilliams (4-2) S: Jim Gott (7) | Second | 6½ out |
| Monday, June 20 |
| » Defeated Mets (43-24), 8-5 | Shea Stadium (1-0) | 38-30 | Won 2 |
| » W: John Smiley (7-4) L: Bob Ojeda (5-6) S: Jeff Robinson (8) | Second | 5½ out |
| Tuesday, June 21 |
| » Lost to Mets (44-24), 9-0 | Shea Stadium (1-1) | 38-31 | |
| » W: Ron Darling (8-4) L: Doug Drabek (5-5) | Second | 6½ out |
| Wednesday, June 22 |
| » Lost to Mets (45-24), 3-0 | Shea Stadium (1-2) | 38-32 | Lost 2 |
| » W: Dwight Gooden (10-3) L: Mike Dunne (4-6) S: Randy Myers (11) | Second | 7½ out |
| Thursday, June 23 |
| » Defeated Expos (34-36), 6-4 | Stade Olympique (1-0) | 39-32 | |
| » W: Jeff Robinson (4-2) L: Jeff Parrett (5-2) S: Jim Gott (8) | Second | 6½ out |
| Friday, June 24 |
| » Defeated Expos (34-37), 5-3 | Stade Olympique (2-0) | 40-32 | Won 2 |
| » W: Jim Gott (4-2) L: Bob McClure (1-3) S: Barry Jones (1) | Second | 6½ out |
| Saturday, June 25 |
| » Defeated Expos (34-38), 5-1 | Stade Olympique (3-0) | 41-32 | Won 3 |
| » W: John Smiley (8-4) L: Brian Holman (0-1) | Second | 5½ out |
| » Major-league debuts: Brian Holman (Expos) |
| Sunday, June 26 |
| » Defeated Expos (34-39), 3-0 | Stade Olympique (4-0) | 42-32 | Won 4 |
| » W: Jeff Robinson (5-2) L: Tim Burke (2-2) | Second | 4½ out |
| Monday, June 27 |
| » Defeated Mets (46-28), 2-1 | Three Rivers Stadium (24-15) | 43-32 | Won 5 |
| » W: Mike Dunne (5-6) L: Dwight Gooden (10-4) S: Jim Gott (9) | Second | 3½ out |
| Tuesday, June 28 |
| » Lost to Mets (47-28), 5-2 | Three Rivers Stadium (24-16) | 43-33 | |
| » W: Sid Fernandez (4-6) L: Brian Fisher (4-6) S: Roger McDowell (8) | Second | 4½ out |
| Wednesday, June 29 |
| » Lost to Mets (48-28), 8-7 | Three Rivers Stadium (24-17) | 43-34 | Lost 2 |
| » W: Roger McDowell (4-1) L: Bob Kipper (1-2) | Second | 5½ out |
| Friday, July 1 |
| » Defeated Giants (39-38), 5-2 | Candlestick Park (3-1) | 44-34 | |
| » W: Jeff Robinson (6-2) L: Atlee Hammaker (4-2) | Second | 5½ out |
| Saturday, July 2 |
| » Lost to Giants (40-38), 2-1 | Candlestick Park (3-2) | 44-35 | |
| » W: Mike LaCoss (6-6) L: Dave Rucker (0-1) S: Scott Garrelts (6) | Second | 6½ out |
| Sunday, July 3 |
| » Lost to Giants (41-38), 4-0 | Candlestick Park (3-3) | 44-36 | Lost 2 |
| » W: Kelly Downs (7-7) L: Mike Dunne (5-7) | Second | 7½ out |
| Monday, July 4 |
| » Lost to Padres (37-46), 4-3 | San Diego/Jack Murphy Stadium (2-2) | 44-37 | Lost 3 |
| » W: Mark Davis (3-6) L: Jim Gott (4-3) | Third | 7½ out |
| Tuesday, July 5 |
| » Defeated Padres (37-47), 3-2 | San Diego/Jack Murphy Stadium (3-2) | 45-37 | |
| » W: Bob Walk (9-4) L: Jimmy Jones (5-8) S: Barry Jones (2) | Second | 6½ out |
| Thursday, July 7 |
| » Defeated Padres (37-48), 2-0 | San Diego/Jack Murphy Stadium (4-2) | 46-37 | Won 2 |
| » W: John Smiley (9-4) L: Andy Hawkins (8-7) S: Jim Gott (10) | Second | 6½ out |
| Friday, July 8 |
| » Defeated Dodgers (48-34), 4-3 | Dodger Stadium (1-3) | 47-37 | Won 3 |
| » W: Doug Drabek (6-5) L: Tim Leary (7-6) S: Jim Gott (11) | Second | 5½ out |
| Saturday, July 9 |
| » Defeated Dodgers (48-35), 8-2 | Dodger Stadium (2-3) | 48-37 | Won 4 |
| » W: Mike Dunne (6-7) L: Shawn Hillegas (2-2) | Second | 4½ out |
| Sunday, July 10 |
| » Defeated Dodgers (48-36), 7-2 | Dodger Stadium (3-3) | 49-37 | Won 5 |
| » W: Bob Walk (10-4) L: Orel Hershiser (13-4) | Second | 3½ out |
| Thursday, July 14 |
| » Defeated Giants (46-40), 9-2 | Three Rivers Stadium (25-17) | 50-37 | Won 6 |
| » W: Brian Fisher (5-6) L: Rick Reuschel (11-5) | Second | 3½ out |
| Friday, July 15 |
| » Defeated Giants (46-41), 8-5 | Three Rivers Stadium (26-17) | 51-37 | Won 7 |
| » W: Bob Kipper (2-2) L: Kelly Downs (8-8) S: Jim Gott (12) | Second | 2½ out |
| Saturday, July 16 |
| » Defeated Giants (46-42), 10-1 | Three Rivers Stadium (27-17) | 52-37 | Won 8 |
| » W: Doug Drabek (7-5) L: Mike LaCoss (7-7) | Second | 2½ out |
| Sunday, July 17 |
| » Defeated Giants (46-43), 5-4 | Three Rivers Stadium (28-17) | 53-37 | Won 9 |
| » W: Jeff Robinson (7-2) L: Joe Price (0-3) S: Jim Gott (13) | Second | 2½ out |
| Tuesday, July 19 |
| » Lost to Padres (43-50), 6-2 | Three Rivers Stadium (28-18) | 53-38 | |
| » W: Jimmy Jones (6-8) L: John Smiley (9-5) | Second | 1½ out |
| » Defeated Padres (43-51), 9-5 | Three Rivers Stadium (29-18) | 54-38 | |
| » W: Brian Fisher (6-6) L: Andy Hawkins (9-8) | Second | 1½ out |
| Wednesday, July 20 |
| » Defeated Padres (43-52), 3-2 | Three Rivers Stadium (30-18) | 55-38 | Won 2 |
| » W: Bob Walk (11-4) L: Dennis Rasmussen (7-7) S: Jim Gott (14) | Second | 1 out |
| Thursday, July 21 |
| » Defeated Dodgers (54-39), 3-2 | Three Rivers Stadium (31-18) | 56-38 | Won 3 |
| » W: Doug Drabek (8-5) L: Orel Hershiser (13-5) S: Jim Gott (15) | Second | ½ out |
| Friday, July 22 |
| » Lost to Dodgers (55-39), 4-2 | Three Rivers Stadium (31-19) | 56-39 | |
| » W: Tim Belcher (7-4) L: Mike Dunne (6-8) S: Jay Howell (11) | Second | 2 out |
| Saturday, July 23 |
| » Lost to Dodgers (56-39), 6-2 | Three Rivers Stadium (31-20) | 56-40 | Lost 2 |
| » W: Tim Leary (10-6) L: John Smiley (9-6) | Second | 2 out |
| Sunday, July 24 |
| » Lost to Dodgers (57-39), 2-1 | Three Rivers Stadium (31-21) | 56-41 | Lost 3 |
| » W: Shawn Hillegas (3-2) L: Brian Fisher (6-7) S: Jay Howell (12) | Second | 2 out |
| Monday, July 25 |
| » Lost to Cardinals (44-54), 5-1 | Busch Stadium II (2-2) | 56-42 | Lost 4 |
| » W: John Tudor (5-4) L: Bob Walk (11-5) | Second | 2 out |
| Tuesday, July 26 |
| » Defeated Cardinals (44-55), 2-1 | Busch Stadium II (3-2) | 57-42 | |
| » W: Doug Drabek (9-5) L: Danny Cox (3-6) S: Jim Gott (16) | Second | 2 out |
| » Major-league debuts: Tim Jones (Cardinals) |
| Wednesday, July 27 |
| » Defeated Cardinals (44-56), 3-2 | Busch Stadium II (4-2) | 58-42 | Won 2 |
| » W: Jeff Robinson (8-2) L: Ken Dayley (2-5) S: Jim Gott (17) | Second | 2 out |
| Friday, July 29 |
| » Lost to Mets (61-40), 1-0 | Shea Stadium (1-3) | 58-43 | |
| » W: Bob Ojeda (8-8) L: John Smiley (9-7) | Second | 3 out |
| Saturday, July 30 |
| » Lost to Mets (62-40), 3-0 | Shea Stadium (1-4) | 58-44 | Lost 2 |
| » W: Sid Fernandez (6-8) L: Brian Fisher (6-8) S: Randy Myers (16) | Second | 4 out |
| Sunday, July 31 |
| » Lost to Mets (63-40), 2-1 | Shea Stadium (1-5) | 58-45 | Lost 3 |
| » W: Ron Darling (11-7) L: Bob Walk (11-6) | Second | 5 out |
| Monday, August 1 |
| » Defeated Mets (63-41), 7-2 | Shea Stadium (2-5) | 59-45 | |
| » W: Doug Drabek (10-5) L: Dwight Gooden (13-6) | Second | 4 out |
| Tuesday, August 2 |
| » Defeated Expos (55-49), 3-2 | Three Rivers Stadium (32-21) | 60-45 | Won 2 |
| » W: Jim Gott (5-3) L: Neal Heaton (3-7) | Second | 4 out |
| Wednesday, August 3 |
| » Lost to Expos (56-49), 6-4 | Three Rivers Stadium (32-22) | 60-46 | |
| » W: Pascual Perez (8-5) L: John Smiley (9-8) S: Tim Burke (10) | Second | 4 out |
| Thursday, August 4 |
| » Lost to Expos (57-49), 3-2 | Three Rivers Stadium (32-23) | 60-47 | Lost 2 |
| » W: John Dopson (3-6) L: Brian Fisher (6-9) S: Tim Burke (11) | Second | 4 out |
| Friday, August 5 |
| » Lost to Mets (65-43), 3-2 | Three Rivers Stadium (32-24) | 60-48 | Lost 3 |
| » W: Ron Darling (12-7) L: Bob Walk (11-7) S: Randy Myers (17) | Second | 5 out |
| Saturday, August 6 |
| » Lost to Mets (66-43), 5-3 | Three Rivers Stadium (32-25) | 60-49 | Lost 4 |
| » W: Bob McClure (2-3) L: Jim Gott (5-4) S: Roger McDowell (11) | Second | 6 out |
| Sunday, August 7 |
| » Lost to Mets (67-43), 6-2 | Three Rivers Stadium (32-26) | 60-50 | Lost 5 |
| » W: David Cone (12-2) L: Bob Kipper (2-3) | Third | 7 out |
| Monday, August 8 |
| » Defeated Mets (67-44), 1-0 | Three Rivers Stadium (33-26) | 61-50 | |
| » W: Rick Reed (1-0) L: Bob Ojeda (8-10) S: Jim Gott (18) | Second | 6 out |
| » Major-league debuts: Rick Reed (Pirates) |
| Tuesday, August 9 |
| » Defeated Expos (60-51), 10-8 | Stade Olympique (5-0) | 62-50 | Won 2 |
| » W: Brian Fisher (7-9) L: John Dopson (3-7) S: Jim Gott (19) | Second | 5 out |
| Wednesday, August 10 |
| » Lost to Expos (61-51), 5-4 | Stade Olympique (5-1) | 62-51 | |
| » W: Dennis Martinez (14-7) L: Bob Walk (11-8) S: Tim Burke (13) | Second | 5 out |
| Thursday, August 11 |
| » Defeated Expos (61-52), 6-1 | Stade Olympique (6-1) | 63-51 | |
| » W: Doug Drabek (11-5) L: Brian Holman (2-4) S: Jim Gott (20) | Second | 5 out |
| Friday, August 12 |
| » Lost to Phillies (50-64), 9-1 | Veteran's Stadium (1-2) | 63-52 | |
| » W: Kevin Gross (11-8) L: Mike Dunne (6-9) | Third | 5½ out |
| » Lost to Phillies (51-64), 6-4 | Veteran's Stadium (1-3) | 63-53 | Lost 2 |
| » W: Steve Bedrosian (3-5) L: Bob Kipper (2-4) | Third | 5½ out |
| Saturday, August 13 |
| » Defeated Phillies (51-65), 10-4 | Veteran's Stadium (2-3) | 64-53 | |
| » W: Jeff Robinson (9-2) L: Greg Harris (3-4) | Third | 4½ out |
| Sunday, August 14 |
| » Defeated Phillies (51-66), 9-8 | Veteran's Stadium (3-3) | 65-53 | Won 2 |
| » W: Jim Gott (6-4) L: Steve Bedrosian (3-6) | Second | 5 out |
| Monday, August 15 |
| » Lost to Braves (41-77), 4-3 | Three Rivers Stadium (33-27) | 65-54 | |
| » W: Charlie Puleo (3-3) L: Bob Walk (11-9) S: Ed Olwine (1) | Second | 5½ out |
| Tuesday, August 16 |
| » Defeated Braves (41-78), 4-2 | Three Rivers Stadium (34-27) | 66-54 | |
| » W: Doug Drabek (12-5) L: Pete Smith (5-12) S: Jim Gott (21) | Second | 5½ out |
| Wednesday, August 17 |
| » Defeated Braves (41-79), 2-1 | Three Rivers Stadium (35-27) | 67-54 | Won 2 |
| » W: Dave LaPoint (11-11) L: Tom Glavine (4-14) S: Jim Gott (22) | Second | 4½ out |
| Friday, August 19 |
| » Lost to Astros (66-56), 5-1 | Three Rivers Stadium (35-28) | 67-55 | |
| » W: Danny Darwin (6-9) L: Mike Dunne (6-10) | Second | 4 out |
| Saturday, August 20 |
| » Defeated Astros (66-57), 2-1 | Three Rivers Stadium (36-28) | 68-55 | |
| » W: John Smiley (10-8) L: Nolan Ryan (9-11) S: Jim Gott (23) | Second | 3½ out |
| Sunday, August 21 |
| » Lost to Astros (67-57), 2-1 | Three Rivers Stadium (36-29) | 68-56 | |
| » W: Juan Agosto (9-0) L: Bob Kipper (2-5) | Second | 3½ out |
| Monday, August 22 |
| » Lost to Reds (63-60), 2-0 | Three Rivers Stadium (36-30) | 68-57 | Lost 2 |
| » W: Danny Jackson (18-5) L: Doug Drabek (12-6) | Second | 4½ out |
| Tuesday, August 23 |
| » Defeated Reds (63-61), 2-0 | Three Rivers Stadium (37-30) | 69-57 | |
| » W: Dave LaPoint (12-11) L: Norm Charlton (0-2) S: Jim Gott (24) | Second | 4½ out |
| Wednesday, August 24 |
| » Lost to Reds (64-61), 6-2 | Three Rivers Stadium (37-31) | 69-58 | |
| » W: Tom Browning (13-4) L: Mike Dunne (6-11) | Second | 5½ out |
| Friday, August 26 |
| » Lost to Astros (69-59), 2-0 | Astrodome (0-4) | 69-59 | Lost 2 |
| » W: Jim Deshaies (9-10) L: John Smiley (10-9) | Second | 6½ out |
| Saturday, August 27 |
| » Lost to Astros (70-59), 3-1 | Astrodome (0-5) | 69-60 | Lost 3 |
| » W: Dave Meads (3-0) L: Bob Walk (11-10) S: Juan Agosto (4) | Second | 7½ out |
| Sunday, August 28 |
| » Defeated Astros (70-60), 4-3 | Astrodome (1-5) | 70-60 | |
| » W: Doug Drabek (13-6) L: Danny Darwin (6-11) S: Jim Gott (25) | Second | 6½ out |
| Monday, August 29 |
| » Defeated Reds (66-64), 8-1 | Riverfront Stadium (3-1) | 71-60 | Won 2 |
| » W: Dave LaPoint (13-11) L: Keith Brown (1-1) | Second | 6½ out |
| Tuesday, August 30 |
| » Lost to Reds (67-64), 6-4 | Riverfront Stadium (3-2) | 71-61 | |
| » W: Danny Jackson (19-6) L: Brian Fisher (7-10) S: John Franco (28) | Second | 7½ out |
| Wednesday, August 31 |
| » Lost to Reds (68-64), 4-1 | Riverfront Stadium (3-3) | 71-62 | Lost 2 |
| » W: Norm Charlton (1-2) L: Jim Gott (6-5) S: John Franco (29) | Second | 7½ out |
| Friday, September 2 |
| » Lost to Braves (46-88), 2-1 | Atlanta-Fulton County Stadium (1-3) | 71-63 | Lost 3 |
| » W: Paul Assenmacher (6-6) L: Jim Gott (6-6) | Second | 8½ out |
| Former Pirate Jim Bagby Jr. dies in Marietta, GA at the age of 72. |
| Monday, September 5 |
| » Lost to Mets (81-54), 7-5 | Three Rivers Stadium (37-32) | 71-64 | Lost 4 |
| » W: David Cone (15-3) L: Jeff Robinson (9-3) S: Randy Myers (22) | Second | 10 out |
| Tuesday, September 6 |
| » Defeated Mets (81-55), 3-2 | Three Rivers Stadium (38-32) | 72-64 | |
| » W: John Smiley (11-9) L: Bob Ojeda (9-13) S: Jim Gott (26) | Second | 9 out |
| Wednesday, September 7 |
| » Defeated Expos (70-68), 5-4 | Three Rivers Stadium (39-32) | 73-64 | Won 2 |
| » W: Doug Drabek (14-6) L: Bryn Smith (10-9) S: Jim Gott (27) | Second | 8 out |
| Thursday, September 8 |
| » Lost to Expos (71-68), 5-4 | Three Rivers Stadium (39-33) | 73-65 | |
| » W: Pascual Perez (10-6) L: Jeff Robinson (9-4) S: Joe Hesketh (8) | Second | 9 out |
| Friday, September 9 |
| » Defeated Phillies (56-84), 5-2 | Three Rivers Stadium (40-33) | 74-65 | |
| » W: Mike Dunne (7-11) L: Bob Sebra (0-2) S: Jim Gott (28) | Second | 9 out |
| Saturday, September 10 |
| » Defeated Phillies (56-85), 5-1 | Three Rivers Stadium (41-33) | 75-65 | Won 2 |
| » W: Dave LaPoint (14-11) L: Shane Rawley (7-14) | Second | 9 out |
| Sunday, September 11 |
| » Lost to Phillies (57-85), 7-4 | Three Rivers Stadium (41-34) | 75-66 | |
| » W: Marvin Freeman (2-2) L: John Smiley (11-10) | Second | 10 out |
| » Major-league debuts: Randy Kramer (Pirates) |
| Monday, September 12 |
| » Lost to Mets (86-56), 3-2 | Shea Stadium (2-6) | 75-67 | Lost 2 |
| » W: Randy Myers (6-3) L: Jeff Robinson (9-5) | Second | 11 out |
| Tuesday, September 13 |
| » Defeated Mets (86-57), 1-0 | Shea Stadium (3-6) | 76-67 | |
| » W: Bob Walk (12-10) L: Dwight Gooden (17-7) S: Jim Gott (29) | Second | 10 out |
| Wednesday, September 14 |
| » Defeated Expos (73-72), 4-1 | Stade Olympique (7-1) | 77-67 | Won 2 |
| » W: Brian Fisher (8-10) L: Tim Burke (3-4) | Second | 10 out |
| Thursday, September 15 |
| » Lost to Expos (74-72), 9-4 | Stade Olympique (7-2) | 77-68 | |
| » W: Randy Johnson (1-0) L: Dave LaPoint (14-12) S: Andy McGaffigan (4) | Second | 11 out |
| » Major-league debuts: Randy Johnson (Expos) |
| Friday, September 16 |
| » Defeated Phillies (59-88), 7-5 | Veteran's Stadium (4-3) | 78-68 | |
| » W: Jeff Robinson (10-5) L: Greg Harris (4-5) S: Jim Gott (30) | Second | 11 out |
| Saturday, September 17 |
| » Defeated Phillies (59-89), 7-2 | Veteran's Stadium (5-3) | 79-68 | Won 2 |
| » W: Doug Drabek (15-6) L: Don Carman (10-12) S: Jeff Robinson (9) | Second | 11 out |
| Sunday, September 18 |
| » Lost to Phillies (60-89), 6-5 | Veteran's Stadium (5-4) | 79-69 | |
| » W: Steve Bedrosian (5-6) L: Randy Kramer (0-1) | Second | 12 out< |