| Tuesday, April 5 |
| » Lost to Astros (1-0), 6-3 | Astrodome (0-1) | 0-1 | |
| » W: Mike Scott (1-0) L: Lance McCullers (0-1) S: Dave Smith (1) | Third | 1 out |
| Wednesday, April 6 |
| » Lost to Astros (2-0), 5-1 | Astrodome (0-2) | 0-2 | Lost 2 |
| » W: Bob Knepper (1-0) L: Andy Hawkins (0-1) | Fourth | 2 out |
| » Major-league debuts: Candy Sierra (Padres) |
| Thursday, April 7 |
| » Lost to Giants (2-1), 6-1 | Candlestick Park (0-1) | 0-3 | Lost 3 |
| » W: Mike Krukow (1-0) L: Eric Show (0-1) | Third | 2½ out |
| Friday, April 8 |
| » Lost to Giants (3-1), 5-1 | Candlestick Park (0-2) | 0-4 | Lost 4 |
| » W: Mike LaCoss (1-0) L: Jimmy Jones (0-1) S: Don Robinson (1) | Fourth | 3½ out |
| Saturday, April 9 |
| » Lost to Giants (4-1), 3-1 | Candlestick Park (0-3) | 0-5 | Lost 5 |
| » W: Rick Reuschel (1-0) L: Mark Grant (0-1) S: Scott Garrelts (1) | Third | 4 out |
| Sunday, April 10 |
| » Defeated Giants (4-2), 6-4 | Candlestick Park (1-3) | 1-5 | |
| » W: Ed Whitson (1-0) L: Dave Dravecky (1-1) S: Lance McCullers (1) | Fifth | 4 out |
| Tuesday, April 12 |
| » Defeated Dodgers (5-2), 5-3 | San Diego/Jack Murphy Stadium (1-0) | 2-5 | Won 2 |
| » W: Andy Hawkins (1-1) L: Don Sutton (0-1) S: Mark Davis (1) | Fourth | 3½ out |
| Wednesday, April 13 |
| » Lost to Dodgers (6-2), 4-3 | San Diego/Jack Murphy Stadium (1-1) | 2-6 | |
| » W: Jay Howell (1-0) L: Eric Show (0-2) S: Jesse Orosco (3) | Fifth | 4½ out |
| Thursday, April 14 |
| » Defeated Dodgers (6-3), 2-0 | San Diego/Jack Murphy Stadium (2-1) | 3-6 | |
| » W: Jimmy Jones (1-1) L: Fernando Valenzuela (1-2) S: Lance McCullers (2) | Fourth | 4½ out |
| Friday, April 15 |
| » Lost to Giants (6-4), 8-3 | San Diego/Jack Murphy Stadium (2-2) | 3-7 | |
| » W: Rick Reuschel (2-0) L: Mark Grant (0-2) S: Atlee Hammaker (1) | Fourth | 4½ out |
| Saturday, April 16 |
| » Defeated Giants (6-5), 2-1 | San Diego/Jack Murphy Stadium (3-2) | 4-7 | |
| » W: Mark Davis (1-0) L: Don Robinson (1-1) | Fifth | 4 out |
| Sunday, April 17 |
| » Lost to Giants (7-5), 9-4 | San Diego/Jack Murphy Stadium (3-3) | 4-8 | |
| » W: Scott Garrelts (1-1) L: Lance McCullers (0-2) | Fourth | 4½ out |
| Monday, April 18 |
| » Lost to Dodgers (9-4), 6-0 | Dodger Stadium (0-1) | 4-9 | Lost 2 |
| » W: Tim Leary (2-0) L: Eric Show (0-3) | Fifth | 5 out |
| Friday, April 22 |
| » Defeated Astros (10-5), 3-1 | San Diego/Jack Murphy Stadium (4-3) | 5-9 | |
| » W: Jimmy Jones (2-1) L: Nolan Ryan (2-1) S: Mark Davis (2) | Fifth | 4½ out |
| » Major-league debuts: Roberto Alomar (Padres) |
| Saturday, April 23 |
| » Defeated Astros (10-6), 4-0 | San Diego/Jack Murphy Stadium (5-3) | 6-9 | Won 2 |
| » W: Ed Whitson (2-0) L: Danny Darwin (1-1) | Fifth | 4½ out |
| Sunday, April 24 |
| » Defeated Astros (10-7), 3-0 | San Diego/Jack Murphy Stadium (6-3) | 7-9 | Won 3 |
| » W: Andy Hawkins (2-1) L: Jim Deshaies (1-2) | Fifth | 4½ out |
| Tuesday, April 26 |
| » Defeated Cardinals (5-13), 1-0 | San Diego/Jack Murphy Stadium (7-3) | 8-9 | Won 4 |
| » W: Eric Show (1-3) L: Randy O'Neal (1-1) | Fifth | 3½ out |
| Wednesday, April 27 |
| » Lost to Cardinals (6-13), 2-1 | San Diego/Jack Murphy Stadium (7-4) | 8-10 | |
| » W: Bob Forsch (1-2) L: Jimmy Jones (2-2) S: Todd Worrell (5) | Fifth | 4½ out |
| Thursday, April 28 |
| » Lost to Cardinals (7-13), 6-4 | San Diego/Jack Murphy Stadium (7-5) | 8-11 | Lost 2 |
| » W: Larry McWilliams (1-0) L: Greg Booker (0-1) S: Todd Worrell (6) | Fifth | 4½ out |
| Friday, April 29 |
| » Defeated Pirates (15-6), 6-3 | San Diego/Jack Murphy Stadium (8-5) | 9-11 | |
| » W: Andy Hawkins (3-1) L: Vicente Palacios (0-1) S: Mark Davis (3) | Fifth | 4½ out |
| Saturday, April 30 |
| » Lost to Pirates (16-6), 5-1 | San Diego/Jack Murphy Stadium (8-6) | 9-12 | |
| » W: Bob Walk (4-1) L: Mark Grant (0-3) | Fifth | 5 out |
| Sunday, May 1 |
| » Lost to Pirates (17-6), 4-2 | San Diego/Jack Murphy Stadium (8-7) | 9-13 | Lost 2 |
| » W: John Smiley (2-2) L: Eric Show (1-4) S: Jim Gott (4) | Fifth | 5 out |
| Monday, May 2 |
| » Lost to Cubs (11-13), 5-2 | San Diego/Jack Murphy Stadium (8-8) | 9-14 | Lost 3 |
| » W: Jamie Moyer (2-2) L: Jimmy Jones (2-3) | Fifth | 5½ out |
| » Major-league debuts: Mark Grace (Cubs) |
| Tuesday, May 3 |
| » Lost to Cubs (12-13), 13-5 | San Diego/Jack Murphy Stadium (8-9) | 9-15 | Lost 4 |
| » W: Calvin Schiraldi (2-2) L: Ed Whitson (2-1) | Fifth | 6½ out |
| Wednesday, May 4 |
| » Lost to Cubs (13-13), 6-3 | San Diego/Jack Murphy Stadium (8-10) | 9-16 | Lost 5 |
| » W: Rick Sutcliffe (2-3) L: Andy Hawkins (3-2) S: Rich Gossage (3) | Fifth | 7½ out |
| Friday, May 6 |
| » Lost to Pirates (18-9), 4-1 | Three Rivers Stadium (0-1) | 9-17 | Lost 6 |
| » W: Barry Jones (1-0) L: Mark Davis (1-1) | Fifth | 8½ out |
| Saturday, May 7 |
| » Defeated Pirates (18-10), 3-2 | Three Rivers Stadium (1-1) | 10-17 | |
| » W: Eric Show (2-4) L: Jim Gott (1-1) | Fourth | 7½ out |
| Sunday, May 8 |
| » Lost to Pirates (19-10), 6-2 | Three Rivers Stadium (1-2) | 10-18 | |
| » W: Doug Drabek (4-2) L: Jimmy Jones (2-4) | Fourth | 8½ out |
| Monday, May 9 |
| » Lost to Cardinals (13-17), 7-1 | Busch Stadium II (0-1) | 10-19 | Lost 2 |
| » W: Larry McWilliams (2-0) L: Ed Whitson (2-2) | Fourth | 9 out |
| Tuesday, May 10 |
| » Lost to Cardinals (14-17), 5-1 | Busch Stadium II (0-2) | 10-20 | Lost 3 |
| » W: Bob Forsch (2-2) L: Andy Hawkins (3-3) S: Todd Worrell (9) | Fifth | 10 out |
| Wednesday, May 11 |
| » Lost to Cubs (16-15), 1-0 | Wrigley Field (0-1) | 10-21 | Lost 4 |
| » W: Greg Maddux (6-2) L: Lance McCullers (0-3) | Fourth | 10 out |
| Thursday, May 12 |
| » Lost to Cubs (17-15), 2-1 | Wrigley Field (0-2) | 10-22 | Lost 5 |
| » W: Bill Landrum (1-0) L: Mark Davis (1-2) | Fifth | 10 out |
| Friday, May 13 |
| » Defeated Expos (15-17), 7-1 | San Diego/Jack Murphy Stadium (9-10) | 11-22 | |
| » W: Jimmy Jones (3-4) L: John Dopson (0-1) | Fifth | 9 out |
| Saturday, May 14 |
| » Defeated Expos (15-18), 3-2 | San Diego/Jack Murphy Stadium (10-10) | 12-22 | Won 2 |
| » W: Ed Whitson (3-2) L: Dennis Martinez (3-5) S: Lance McCullers (3) | Fifth | 9 out |
| Sunday, May 15 |
| » Defeated Expos (15-19), 2-1 | San Diego/Jack Murphy Stadium (11-10) | 13-22 | Won 3 |
| » W: Andy Hawkins (4-3) L: Jeff Parrett (3-1) S: Mark Davis (4) | Fifth | 9 out |
| Monday, May 16 |
| » Lost to Mets (24-11), 7-4 | San Diego/Jack Murphy Stadium (11-11) | 13-23 | |
| » W: Dwight Gooden (7-0) L: Greg Booker (0-2) S: Roger McDowell (4) | Fifth | 9½ out |
| Tuesday, May 17 |
| » Lost to Mets (25-11), 1-0 | San Diego/Jack Murphy Stadium (11-12) | 13-24 | Lost 2 |
| » W: David Cone (5-0) L: Mark Davis (1-3) S: Randy Myers (5) | Fifth | 9½ out |
| Wednesday, May 18 |
| » Lost to Mets (26-11), 5-2 | San Diego/Jack Murphy Stadium (11-13) | 13-25 | Lost 3 |
| » W: Bob Ojeda (4-2) L: Jimmy Jones (3-5) | Fifth | 9½ out |
| Thursday, May 19 |
| » Lost to Mets (27-11), 9-4 | San Diego/Jack Murphy Stadium (11-14) | 13-26 | Lost 4 |
| » W: Ron Darling (4-3) L: Ed Whitson (3-3) | Fifth | 10½ out |
| Friday, May 20 |
| » Defeated Phillies (14-23), 4-3 | San Diego/Jack Murphy Stadium (12-14) | 14-26 | |
| » W: Mark Davis (2-3) L: Kent Tekulve (1-4) | Fifth | 10 out |
| Saturday, May 21 |
| » Lost to Phillies (15-23), 4-3 | San Diego/Jack Murphy Stadium (12-15) | 14-27 | |
| » W: Shane Rawley (3-5) L: Mark Grant (0-4) S: Steve Bedrosian (1) | Fifth | 10 out |
| Sunday, May 22 |
| » Defeated Phillies (15-24), 9-2 | San Diego/Jack Murphy Stadium (13-15) | 15-27 | |
| » W: Eric Show (3-4) L: Kevin Gross (4-2) | Fifth | 10 out |
| Tuesday, May 24 |
| » Lost to Expos (19-22), 7-6 | Stade Olympique (0-1) | 15-28 | |
| » W: Andy McGaffigan (2-0) L: Candy Sierra (0-1) | Fifth | 10½ out |
| Wednesday, May 25 |
| » Lost to Expos (20-22), 6-2 | Stade Olympique (0-2) | 15-29 | Lost 2 |
| » W: Dennis Martinez (4-6) L: Ed Whitson (3-4) | Fifth | 10½ out |
| Thursday, May 26 |
| » Lost to Expos (21-22), 6-2 | Stade Olympique (0-3) | 15-30 | Lost 3 |
| » W: Bryn Smith (3-3) L: Andy Hawkins (4-4) S: Jeff Parrett (2) | Sixth | 11½ out |
| Friday, May 27 |
| » Defeated Mets (31-14), 2-0 | Shea Stadium (1-0) | 16-30 | |
| » W: Mark Grant (1-4) L: Sid Fernandez (2-4) S: Mark Davis (5) | Fifth | 11½ out |
| Saturday, May 28 |
| » Lost to Mets (32-14), 5-1 | Shea Stadium (1-1) | 16-31 | |
| » Manager: Jack McKeon |
| » W: David Cone (7-0) L: Eric Show (3-5) S: Roger McDowell (6) | Sixth | 11½ out |
| Sunday, May 29 |
| » Defeated Mets (32-15), 6-3 | Shea Stadium (2-1) | 17-31 | |
| » W: Jimmy Jones (4-5) L: Bob Ojeda (4-4) S: Mark Davis (6) | Fifth | 11½ out |
| Monday, May 30 |
| » Lost to Phillies (19-27), 7-3 | Veteran's Stadium (0-1) | 17-32 | |
| » W: Shane Rawley (4-5) L: Ed Whitson (3-5) | Fifth | 11½ out |
| Tuesday, May 31 |
| » Defeated Phillies (19-28), 8-0 | Veteran's Stadium (1-1) | 18-32 | |
| » W: Andy Hawkins (5-4) L: David Palmer (0-5) | Fifth | 10½ out |
| Wednesday, June 1 |
| » Lost to Phillies (20-28), 9-7 | Veteran's Stadium (1-2) | 18-33 | |
| » W: Kent Tekulve (2-4) L: Lance McCullers (0-4) S: Greg Harris (1) | Sixth | 11½ out |
| Friday, June 3 |
| » Defeated Braves (17-32), 7-5 | San Diego/Jack Murphy Stadium (14-15) | 19-33 | |
| » W: Eric Show (4-5) L: Kevin Coffman (2-6) S: Mark Davis (7) | Fifth | 11½ out |
| Saturday, June 4 |
| » Defeated Braves (17-33), 6-5 | San Diego/Jack Murphy Stadium (15-15) | 20-33 | Won 2 |
| » W: Ed Whitson (4-5) L: Charlie Puleo (0-2) S: Lance McCullers (4) | Fifth | 10½ out |
| Sunday, June 5 |
| » Lost to Braves (18-33), 3-1 | San Diego/Jack Murphy Stadium (15-16) | 20-34 | |
| » W: Tom Glavine (3-6) L: Andy Hawkins (5-5) S: Bruce Sutter (8) | Fifth | 11½ out |
| Monday, June 6 |
| » Lost to Reds (25-30), 12-0 | San Diego/Jack Murphy Stadium (15-17) | 20-35 | Lost 2 |
| » W: Tom Browning (3-3) L: Mark Grant (1-5) | Fifth | 11½ out |
| Tuesday, June 7 |
| » Defeated Reds (25-31), 6-2 | San Diego/Jack Murphy Stadium (16-17) | 21-35 | |
| » W: Ed Whitson (5-5) L: Danny Jackson (5-3) | Fifth | 10½ out |
| Wednesday, June 8 |
| » Lost to Reds (26-31), 7-1 | San Diego/Jack Murphy Stadium (16-18) | 21-36 | |
| » W: Jose Rijo (7-1) L: Eric Show (4-6) | Fifth | 11½ out |
| Thursday, June 9 |
| » Defeated Reds (26-32), 3-1 | San Diego/Jack Murphy Stadium (17-18) | 22-36 | |
| » W: Jimmy Jones (5-5) L: Ron Robinson (2-5) S: Mark Davis (8) | Fifth | 11½ out |
| Friday, June 10 |
| » Defeated Dodgers (32-24), 4-3 | San Diego/Jack Murphy Stadium (18-18) | 23-36 | Won 2 |
| » W: Lance McCullers (1-4) L: Jay Howell (2-2) | Fifth | 10½ out |
| Saturday, June 11 |
| » Defeated Dodgers (32-25), 2-1 | San Diego/Jack Murphy Stadium (19-18) | 24-36 | Won 3 |
| » W: Dennis Rasmussen (3-6) L: Don Sutton (3-4) | Fifth | 9½ out |
| Sunday, June 12 |
| » Defeated Dodgers (32-26), 5-2 | San Diego/Jack Murphy Stadium (20-18) | 25-36 | Won 4 |
| » W: Ed Whitson (6-5) L: Tim Belcher (3-4) S: Mark Davis (9) | Fifth | 8½ out |
| Monday, June 13 |
| » Defeated Giants (31-31), 7-3 | San Diego/Jack Murphy Stadium (21-18) | 26-36 | Won 5 |
| » W: Eric Show (5-6) L: Mike Krukow (4-4) S: Mark Davis (10) | Fifth | 8 out |
| Tuesday, June 14 |
| » Defeated Giants (31-32), 8-5 | San Diego/Jack Murphy Stadium (22-18) | 27-36 | Won 6 |
| » W: Greg Booker (1-2) L: Craig Lefferts (1-5) S: Lance McCullers (5) | Fifth | 8 out |
| Wednesday, June 15 |
| » Lost to Giants (32-32), 4-2 | San Diego/Jack Murphy Stadium (22-19) | 27-37 | |
| » W: Rick Reuschel (10-3) L: Andy Hawkins (5-6) S: Don Robinson (5) | Fifth | 9 out |
| Friday, June 17 |
| » Defeated Dodgers (34-28), 7-4 | Dodger Stadium (1-1) | 28-37 | |
| » W: Ed Whitson (7-5) L: Tim Leary (5-5) S: Mark Davis (11) | Fifth | 6½ out |
| » Defeated Dodgers (34-29), 4-3 | Dodger Stadium (2-1) | 29-37 | Won 2 |
| » W: Dennis Rasmussen (4-6) L: Brian Holton (2-1) S: Lance McCullers (6) | Fifth | 6½ out |
| Saturday, June 18 |
| » Lost to Dodgers (35-29), 3-0 | Dodger Stadium (2-2) | 29-38 | |
| » W: Tim Belcher (4-4) L: Eric Show (5-7) S: Jay Howell (8) | Fourth | 7½ out |
| Sunday, June 19 |
| » Lost to Dodgers (36-29), 12-2 | Dodger Stadium (2-3) | 29-39 | Lost 2 |
| » W: Orel Hershiser (10-3) L: Jimmy Jones (5-6) | Fifth | 9½ out |
| » Lost to Dodgers (37-29), 5-4 | Dodger Stadium (2-4) | 29-40 | Lost 3 |
| » W: Tim Crews (2-0) L: Mark Davis (2-4) | Fifth | 9½ out |
| Monday, June 20 |
| » Defeated Giants (33-35), 2-1 | Candlestick Park (2-3) | 30-40 | |
| » W: Andy Hawkins (6-6) L: Mike LaCoss (5-5) S: Mark Davis (12) | Fourth | 9½ out |
| Tuesday, June 21 |
| » Defeated Giants (33-36), 8-3 | Candlestick Park (3-3) | 31-40 | Won 2 |
| » W: Dennis Rasmussen (5-6) L: Rick Reuschel (10-4) | Fourth | 9½ out |
| Wednesday, June 22 |
| » Lost to Giants (34-36), 8-7 | Candlestick Park (3-4) | 31-41 | |
| » W: Craig Lefferts (2-5) L: Mark Davis (2-5) | Fifth | 9½ out |
| Friday, June 24 |
| » Lost to Braves (25-44), 4-3 | Atlanta-Fulton County Stadium (0-1) | 31-42 | Lost 2 |
| » W: Pete Smith (2-7) L: Eric Show (5-8) S: Bruce Sutter (11) | Fifth | 10½ out |
| Saturday, June 25 |
| » Lost to Braves (26-44), 8-4 | Atlanta-Fulton County Stadium (0-2) | 31-43 | Lost 3 |
| » W: Charlie Puleo (1-3) L: Jimmy Jones (5-7) | Fifth | 11½ out |
| Sunday, June 26 |
| » Defeated Braves (26-45), 2-1 | Atlanta-Fulton County Stadium (1-2) | 32-43 | |
| » W: Andy Hawkins (7-6) L: Zane Smith (3-5) S: Mark Davis (13) | Fifth | 11½ out |
| Monday, June 27 |
| » Defeated Reds (33-41), 9-2 | Riverfront Stadium (1-0) | 33-43 | Won 2 |
| » W: Dennis Rasmussen (6-6) L: Jack Armstrong (0-2) | Fifth | 11½ out |
| Tuesday, June 28 |
| » Lost to Reds (34-41), 4-3 | Riverfront Stadium (1-1) | 33-44 | |
| » W: Danny Jackson (8-4) L: Mark Grant (1-6) | Fifth | 11½ out |
| Wednesday, June 29 |
| » Defeated Reds (34-42), 3-2 | Riverfront Stadium (2-1) | 34-44 | |
| » W: Eric Show (6-8) L: Tim Birtsas (0-1) S: Mark Davis (14) | Fifth | 11½ out |
| Thursday, June 30 |
| » Lost to Reds (35-42), 4-3 | Riverfront Stadium (2-2) | 34-45 | |
| » W: John Franco (2-5) L: Mark Davis (2-6) | Fifth | 12 out |
| Friday, July 1 |
| » Defeated Cardinals (37-41), 5-1 | San Diego/Jack Murphy Stadium (23-19) | 35-45 | |
| » W: Andy Hawkins (8-6) L: Jose DeLeon (5-6) | Fifth | 11 out |
| Saturday, July 2 |
| » Defeated Cardinals (37-42), 7-5 | San Diego/Jack Murphy Stadium (24-19) | 36-45 | Won 2 |
| » W: Mark Grant (2-6) L: Ken Dayley (2-4) S: Mark Davis (15) | Fifth | 11 out |
| Sunday, July 3 |
| » Lost to Cardinals (38-42), 5-4 | San Diego/Jack Murphy Stadium (24-20) | 36-46 | |
| » W: Todd Worrell (4-4) L: Lance McCullers (1-5) | Fifth | 11 out |
| Monday, July 4 |
| » Defeated Pirates (44-37), 4-3 | San Diego/Jack Murphy Stadium (25-20) | 37-46 | |
| » W: Mark Davis (3-6) L: Jim Gott (4-3) | Fifth | 11 out |
| Tuesday, July 5 |
| » Lost to Pirates (45-37), 3-2 | San Diego/Jack Murphy Stadium (25-21) | 37-47 | |
| » W: Bob Walk (9-4) L: Jimmy Jones (5-8) S: Barry Jones (2) | Fifth | 12 out |
| Thursday, July 7 |
| » Lost to Pirates (46-37), 2-0 | San Diego/Jack Murphy Stadium (25-22) | 37-48 | Lost 2 |
| » W: John Smiley (9-4) L: Andy Hawkins (8-7) S: Jim Gott (10) | Fifth | 13 out |
| Friday, July 8 |
| » Defeated Cubs (44-39), 4-2 | San Diego/Jack Murphy Stadium (26-22) | 38-48 | |
| » W: Dennis Rasmussen (7-6) L: Jeff Pico (3-4) | Fifth | 12 out |
| Saturday, July 9 |
| » Defeated Cubs (44-40), 4-2 | San Diego/Jack Murphy Stadium (27-22) | 39-48 | Won 2 |
| » W: Ed Whitson (8-5) L: Rick Sutcliffe (7-6) S: Mark Davis (16) | Fifth | 11 out |
| Sunday, July 10 |
| » Lost to Cubs (45-40), 4-2 | San Diego/Jack Murphy Stadium (27-23) | 39-49 | |
| » W: Greg Maddux (15-3) L: Eric Show (6-9) | Fifth | 11 out |
| Thursday, July 14 |
| » Defeated Cardinals (38-49), 3-1 | Busch Stadium II (1-2) | 40-49 | |
| » W: Andy Hawkins (9-7) L: Jose DeLeon (5-7) | Fifth | 11½ out |
| Friday, July 15 |
| » Defeated Cardinals (38-50), 7-3 | Busch Stadium II (2-2) | 41-49 | Won 2 |
| » W: Mark Davis (4-6) L: Todd Worrell (4-6) | Fifth | 11½ out |
| Saturday, July 16 |
| » Lost to Cardinals (39-50), 3-2 | Busch Stadium II (2-3) | 41-50 | |
| » W: John Costello (2-0) L: Mark Davis (4-7) | Fifth | 12 out |
| Sunday, July 17 |
| » Defeated Cardinals (39-51), 3-1 | Busch Stadium II (3-3) | 42-50 | |
| » W: Eric Show (7-9) L: Joe Magrane (1-4) | Fifth | 12½ out |
| Tuesday, July 19 |
| » Defeated Pirates (53-38), 6-2 | Three Rivers Stadium (2-2) | 43-50 | Won 2 |
| » W: Jimmy Jones (6-8) L: John Smiley (9-5) | Fifth | 12½ out |
| » Lost to Pirates (54-38), 9-5 | Three Rivers Stadium (2-3) | 43-51 | |
| » W: Brian Fisher (6-6) L: Andy Hawkins (9-8) | Fifth | 12½ out |
| Wednesday, July 20 |
| » Lost to Pirates (55-38), 3-2 | Three Rivers Stadium (2-4) | 43-52 | Lost 2 |
| » W: Bob Walk (11-4) L: Dennis Rasmussen (7-7) S: Jim Gott (14) | Fifth | 12½ out |
| Thursday, July 21 |
| » Defeated Cubs (46-48), 3-1 | Wrigley Field (1-2) | 44-52 | |
| » W: Ed Whitson (9-5) L: Jamie Moyer (5-9) S: Lance McCullers (7) | Fifth | 11½ out |
| Friday, July 22 |
| » Lost to Cubs (47-48), 5-4 | Wrigley Field (1-3) | 44-53 | |
| » W: Frank DiPino (1-3) L: Lance McCullers (1-6) | Fifth | 12½ out |
| Saturday, July 23 |
| » Lost to Cubs (48-48), 3-2 | Wrigley Field (1-4) | 44-54 | Lost 2 |
| » W: Calvin Schiraldi (5-8) L: Mark Grant (2-7) S: Rich Gossage (10) | Fifth | 13½ out |
| Sunday, July 24 |
| » Defeated Cubs (48-49), 2-1 | Wrigley Field (2-4) | 45-54 | |
| » W: Jimmy Jones (7-8) L: Rick Sutcliffe (7-9) S: Mark Davis (17) | Fifth | 13½ out |
| Tuesday, July 26 |
| » Defeated Astros (52-47), 5-1 | San Diego/Jack Murphy Stadium (28-23) | 46-54 | Won 2 |
| » W: Dennis Rasmussen (8-7) L: Jim Deshaies (7-7) | Fifth | 13½ out |
| Wednesday, July 27 |
| » Lost to Astros (53-47), 4-1 | San Diego/Jack Murphy Stadium (28-24) | 46-55 | |
| » W: Nolan Ryan (8-7) L: Ed Whitson (9-6) S: Dave Smith (17) | Fifth | 13½ out |
| Thursday, July 28 |
| » Lost to Astros (54-47), 3-2 | San Diego/Jack Murphy Stadium (28-25) | 46-56 | Lost 2 |
| » W: Bob Knepper (11-3) L: Eric Show (7-10) S: Larry Andersen (5) | Fifth | 14 out |
| Friday, July 29 |
| » Defeated Reds (50-52), 5-3 | San Diego/Jack Murphy Stadium (29-25) | 47-56 | |
| » W: Andy Hawkins (10-8) L: Jack Armstrong (2-4) S: Mark Davis (18) | Fifth | 13 out |
| Saturday, July 30 |
| » Lost to Reds (51-52), 2-0 | San Diego/Jack Murphy Stadium (29-26) | 47-57 | |
| » W: Tom Browning (10-4) L: Jimmy Jones (7-9) S: John Franco (22) | Fifth | 13 out |
| Sunday, July 31 |
| » Defeated Reds (51-53), 8-5 | San Diego/Jack Murphy Stadium (30-26) | 48-57 | |
| » W: Dennis Rasmussen (9-7) L: Tim Birtsas (0-2) S: Lance McCullers (8) | Fourth | 13 out |
| Monday, August 1 |
| » Defeated Braves (35-70), 6-3 | San Diego/Jack Murphy Stadium (31-26) | 49-57 | Won 2 |
| » W: Ed Whitson (10-6) L: Tom Glavine (3-12) S: Dave Leiper (1) | Fifth | 12 out |
| Tuesday, August 2 |
| » Defeated Braves (35-71), 4-1 | San Diego/Jack Murphy Stadium (32-26) | 50-57 | Won 3 |
| » W: Eric Show (8-10) L: John Smoltz (1-2) | Fourth | 12 out |
| Wednesday, August 3 |
| » Lost to Braves (36-71), 4-2 | San Diego/Jack Murphy Stadium (32-27) | 50-58 | |
| » W: Zane Smith (5-8) L: Andy Hawkins (10-9) | Fifth | 12 out |
| Friday, August 5 |
| » Lost to Reds (54-54), 10-7 | Riverfront Stadium (2-3) | 50-59 | Lost 2 |
| » W: Frank Williams (2-1) L: Mark Grant (2-8) S: John Franco (23) | Fifth | 12 out |
| Saturday, August 6 |
| » Defeated Reds (54-55), 4-1 | Riverfront Stadium (3-3) | 51-59 | |
| » W: Dennis Rasmussen (10-7) L: Jose Rijo (11-7) S: Mark Davis (19) | Fifth | 12 out |
| Sunday, August 7 |
| » Lost to Reds (55-55), 4-3 | Riverfront Stadium (3-4) | 51-60 | |
| » W: Tom Browning (11-4) L: Ed Whitson (10-7) S: John Franco (24) | Fifth | 12 out |
| Tuesday, August 9 |
| » Defeated Braves (38-74), 5-1 | Atlanta-Fulton County Stadium (2-2) | 52-60 | |
| » W: Eric Show (9-10) L: Zane Smith (5-9) | Fifth | 10½ out |
| Wednesday, August 10 |
| » Defeated Braves (38-75), 5-4 | Atlanta-Fulton County Stadium (3-2) | 53-60 | Won 2 |
| » W: Dave Leiper (1-0) L: German Jimenez (1-4) | Fifth | 10½ out |
| Thursday, August 11 |
| » Lost to Braves (39-75), 2-1 | Atlanta-Fulton County Stadium (3-3) | 53-61 | |
| » W: Pete Smith (5-11) L: Jimmy Jones (7-10) | Fifth | 10½ out |
| Friday, August 12 |
| » Defeated Astros (62-53), 4-3 | Astrodome (1-2) | 54-61 | |
| » W: Dennis Rasmussen (11-7) L: Bob Knepper (12-4) S: Mark Davis (20) | Fifth | 10½ out |
| Saturday, August 13 |
| » Lost to Astros (63-53), 1-0 | Astrodome (1-3) | 54-62 | |
| » W: Mike Scott (13-3) L: Ed Whitson (10-8) | Fifth | 11½ out |
| Sunday, August 14 |
| » Defeated Astros (63-54), 6-1 | Astrodome (2-3) | 55-62 | |
| » W: Eric Show (10-10) L: Joaquin Andujar (1-5) | Fifth | 10½ out |
| Monday, August 15 |
| » Lost to Astros (64-54), 7-3 | Astrodome (2-4) | 55-63 | |
| » W: Nolan Ryan (9-10) L: Andy Hawkins (10-10) | Fifth | 11½ out |
| Tuesday, August 16 |
| » Defeated Expos (63-55), 6-2 | San Diego/Jack Murphy Stadium (33-27) | 56-63 | |
| » W: Jimmy Jones (8-10) L: Brian Holman (2-5) S: Lance McCullers (9) | Fifth | 11½ out |
| Wednesday, August 17 |
| » Defeated Expos (63-56), 4-2 | San Diego/Jack Murphy Stadium (34-27) | 57-63 | Won 2 |
| » W: Dennis Rasmussen (12-7) L: Bryn Smith (8-7) S: Mark Davis (21) | Fifth | 11½ out |
| Thursday, August 18 |
| » Defeated Expos (63-57), 5-4 | San Diego/Jack Murphy Stadium (35-27) | 58-63 | Won 3 |
| » W: Lance McCullers (2-6) L: Tim Burke (3-3) | Fifth | 11½ out |
| Friday, August 19 |
| » Defeated Mets (71-51), 3-2 | San Diego/Jack Murphy Stadium (36-27) | 59-63 | Won 4 |
| » W: Mark Davis (5-7) L: Randy Myers (5-3) | Fifth | 11½ out |
| Sunday, August 21 |
| » Defeated Mets (71-52), 1-0 | San Diego/Jack Murphy Stadium (37-27) | 60-63 | Won 5 |
| » W: Andy Hawkins (11-10) L: Ron Darling (12-9) S: Mark Davis (22) | Fourth | 12 out |
| Monday, August 22 |
| » Lost to Phillies (52-72), 6-5 | San Diego/Jack Murphy Stadium (37-28) | 60-64 | |
| » W: Greg Harris (4-4) L: Jimmy Jones (8-11) S: Steve Bedrosian (22) | Fourth | 12 out |
| Tuesday, August 23 |
| » Defeated Phillies (52-73), 9-1 | San Diego/Jack Murphy Stadium (38-28) | 61-64 | |
| » W: Ed Whitson (11-8) L: Kevin Gross (11-10) | Fourth | 11 out |
| Wednesday, August 24 |
| » Defeated Phillies (52-74), 5-2 | San Diego/Jack Murphy Stadium (39-28) | 62-64 | Won 2 |
| » W: Eric Show (11-10) L: David Palmer (7-9) | Fourth | 10 out |
| Friday, August 26 |
| » Defeated Expos (65-62), 4-3 | Stade Olympique (1-3) | 63-64 | Won 3 |
| » W: Andy Hawkins (12-10) L: John Dopson (3-8) S: Mark Davis (23) | Fifth | 10 out |
| Saturday, August 27 |
| » Lost to Expos (66-62), 4-0 | Stade Olympique (1-4) | 63-65 | |
| » W: Bryn Smith (9-8) L: Jimmy Jones (8-12) S: Joe Hesketh (7) | Fifth | 11 out |
| Sunday, August 28 |
| » Defeated Expos (66-63), 5-3 | Stade Olympique (2-4) | 64-65 | |
| » W: Lance McCullers (3-6) L: Neal Heaton (3-10) | Fifth | 11 out |
| Monday, August 29 |
| » Lost to Mets (77-53), 6-0 | Shea Stadium (2-2) | 64-66 | |
| » W: David Cone (14-3) L: Eric Show (11-11) | Fifth | 12 out |
| Tuesday, August 30 |
| » Lost to Mets (78-53), 1-0 | Shea Stadium (2-3) | 64-67 | Lost 2 |
| » W: Bob Ojeda (9-12) L: Dennis Rasmussen (12-8) | Fifth | 13 out |
| Wednesday, August 31 |
| » Defeated Mets (78-54), 6-3 | Shea Stadium (3-3) | 65-67 | |
| » W: Andy Hawkins (13-10) L: Terry Leach (6-2) S: Mark Davis (24) | Fifth | 12 out |
| Friday, September 2 |
| » Defeated Phillies (54-79), 7-4 | Veteran's Stadium (2-2) | 66-67 | Won 2 |
| » W: Jimmy Jones (9-12) L: Don Carman (9-10) S: Mark Davis (25) | Fifth | 11 out |
| Saturday, September 3 |
| » Defeated Phillies (54-80), 5-2 | Veteran's Stadium (3-2) | 67-67 | Won 3 |
| » W: Ed Whitson (12-8) L: Kevin Gross (11-12) | Fifth | 10 out |
| Monday, September 5 |
| » Defeated Giants (70-67), 7-4 | Candlestick Park (4-4) | 68-67 | Won 4 |
| » W: Eric Show (12-11) L: Trevor Wilson (0-1) | Fifth | 10 out |
| » Major-league debuts: Trevor Wilson (Giants) |
| Tuesday, September 6 |
| » Defeated Giants (70-68), 4-3 | Candlestick Park (5-4) | 69-67 | Won 5 |
| » W: Dennis Rasmussen (13-8) L: Scott Garrelts (5-8) S: Mark Davis (26) | Fifth | 9 out |
| Wednesday, September 7 |
| » Defeated Reds (72-66), 1-0 | San Diego/Jack Murphy Stadium (40-28) | 70-67 | Won 6 |
| » W: Andy Hawkins (14-10) L: Ron Robinson (3-7) S: Mark Davis (27) | Fourth | 9 out |
| » Major-league debuts: Lenny Harris (Reds) |
| Thursday, September 8 |
| » Lost to Reds (73-66), 2-1 | San Diego/Jack Murphy Stadium (40-29) | 70-68 | |
| » W: Jose Rijo (12-8) L: Ed Whitson (12-9) S: John Franco (32) | Fifth | 9 out |
| Friday, September 9 |
| » Lost to Braves (49-90), 5-4 | San Diego/Jack Murphy Stadium (40-30) | 70-69 | Lost 2 |
| » W: Jose Alvarez (4-6) L: Mark Davis (5-8) S: Bruce Sutter (14) | Fifth | 9 out |
| Saturday, September 10 |
| » Defeated Braves (49-91), 6-2 | San Diego/Jack Murphy Stadium (41-30) | 71-69 | |
| » W: Eric Show (13-11) L: Rick Mahler (9-14) | Fifth | 9 out |
| Sunday, September 11 |
| » Defeated Braves (49-92), 8-2 | San Diego/Jack Murphy Stadium (42-30) | 72-69 | Won 2 |
| » W: Dennis Rasmussen (14-8) L: Charlie Puleo (3-5) | Fourth | 9 out |
| Monday, September 12 |
| » Lost to Giants (73-71), 4-2 | San Diego/Jack Murphy Stadium (42-31) | 72-70 | |
| » W: Dennis Cook (1-0) L: Andy Hawkins (14-11) S: Joe Price (4) | Fifth | 10 out |
| » Major-league debuts: Dennis Cook (Giants) |
| Tuesday, September 13 |
| » Lost to Giants (74-71), 4-1 | San Diego/Jack Murphy Stadium (42-32) | 72-71 | Lost 2 |
| » W: Rick Reuschel (18-8) L: Ed Whitson (12-10) S: Craig Lefferts (8) | Fifth | 11 out |
| Wednesday, September 14 |
| » Lost to Giants (75-71), 6-5 | San Diego/Jack Murphy Stadium (42-33) | 72-72 | Lost 3 |
| » W: Don Robinson (7-4) L: Jimmy Jones (9-13) S: Craig Lefferts (9) | Fifth | 12 out |
| » Major-league debuts: Greg Harris (Padres) |
| Saturday, September 17 |
| » Defeated Braves (49-96), 9-4 | Atlanta-Fulton County Stadium (4-3) | 73-72 | |
| » W: Eric Show (14-11) L: Pete Smith (7-14) S: Lance McCullers (10) | Fifth | 12 out |
| » Lost to Braves (50-96), 6-3 | Atlanta-Fulton County Stadium (4-4) | 73-73 | |
| » W: Tom Glavine (7-16) L: Dennis Rasmussen (14-9) S: Paul Assenmacher (5) | Fifth | 12 out |
| » Major-league debuts: Mark Lemke (Braves) |
| Sunday, September 18 |
| » Lost to Braves (51-96), 6-5 | Atlanta-Fulton County Stadium (4-5) | 73-74 | Lost 2 |
| » W: Paul Assenmacher (8-6) L: Mark Davis (5-9) | Fourth | 13 out |
| Monday, September 19 |
| » Lost to Reds (78-71), 7-2 | Riverfront Stadium (3-5) | 73-75 | Lost 3 |
| » W: Danny Jackson (22-7) L: Ed Whitson (12-11) | Fourth | 14 out |
| » Major-league debuts: Jerald Clark (Padres) |
| Tuesday, September 20 |
| » Lost to Reds (79-71), 7-2 | Riverfront Stadium (3-6) | 73-76 | Lost 4 |
| » W: Norm Charlton (3-4) L: Jimmy Jones (9-14) | Fifth | 15 out |
| Wednesday, September 21 |
| » Defeated Dodgers (88-62), 9-3 | Dodger Stadium (3-4) | 74-76 | |
| » W: Dennis Rasmussen (15-9) L: Ramon Martinez (1-3) | Fourth | 15 out |
| » Lost to Dodgers (89-62), 6-5 | Dodger Stadium (3-5) | 74-77 | |
| » W: Jay Howell (5-3) L: Mark Davis (5-10) | Fourth | 15 out |
| Thursday, September 22 |
| » Defeated Dodgers (89-63), 5-4 | Dodger Stadium (4-5) | 75-77 | |
| » W: Eric Show (15-11) L: Alejandro Pena (5-7) | Fifth | 14 out |
| Friday, September 23 |
| » Defeated Astros (80-74), 4-3 | San Diego/Jack Murphy Stadium (43-33) | |