| Monday, April 4 |
| » Lost to Brewers (1-0), 12-0 | Memorial Stadium (0-1) | 0-1 | |
| » W: Teddy Higuera (1-0) L: Mike Boddicker (0-1) | Third | 1 out |
| » Major-league debuts: Oswaldo Peraza (Orioles) Joey Meyer (Brewers) |
| Wednesday, April 6 |
| » Lost to Brewers (2-0), 3-1 | Memorial Stadium (0-2) | 0-2 | Lost 2 |
| » W: Chris Bosio (1-0) L: Mike Morgan (0-1) | Third | 2 out |
| Friday, April 8 |
| » Lost to Indians (3-1), 3-0 | Cleveland Stadium (0-1) | 0-3 | Lost 3 |
| » W: Scott Bailes (1-0) L: Mark Thurmond (0-1) | Fifth | 3 out |
| Saturday, April 9 |
| » Lost to Indians (4-1), 12-1 | Cleveland Stadium (0-2) | 0-4 | Lost 4 |
| » W: Tom Candiotti (1-0) L: Mike Boddicker (0-2) | Fifth | 4 out |
| » Major-league debuts: Jose Bautista (Orioles) |
| Sunday, April 10 |
| » Lost to Indians (5-1), 6-3 | Cleveland Stadium (0-3) | 0-5 | Lost 5 |
| » W: Rich Yett (1-0) L: Scott McGregor (0-1) S: Dan Schatzeder (1) | Fifth | 5 out |
| Monday, April 11 |
| » Lost to Indians (6-1), 7-2 | Cleveland Stadium (0-4) | 0-6 | Lost 6 |
| » W: Greg Swindell (2-0) L: Mike Morgan (0-2) | Sixth | 5½ out |
| Tuesday, April 12 |
| » Lost to Royals (4-3), 6-1 | Memorial Stadium (0-3) | 0-7 | Lost 7 |
| » Manager: Frank Robinson |
| » W: Mark Gubicza (2-0) L: Oswaldo Peraza (0-1) | Sixth | 6 out |
| Wednesday, April 13 |
| » Lost to Royals (5-3), 9-3 | Memorial Stadium (0-4) | 0-8 | Lost 8 |
| » W: Floyd Bannister (2-0) L: Mark Thurmond (0-2) | Seventh | 7 out |
| Thursday, April 14 |
| » Lost to Royals (6-3), 4-3 | Memorial Stadium (0-5) | 0-9 | Lost 9 |
| » W: Bret Saberhagen (1-1) L: Mike Boddicker (0-3) S: Gene Garber (2) | Seventh | 8 out |
| Friday, April 15 |
| » Lost to Indians (9-2), 3-2 | Memorial Stadium (0-6) | 0-10 | Lost 10 |
| » W: Rich Yett (2-0) L: Scott McGregor (0-2) S: Doug Jones (1) | Seventh | 9 out |
| Saturday, April 16 |
| » Lost to Indians (10-2), 1-0 | Memorial Stadium (0-7) | 0-11 | Lost 11 |
| » W: Greg Swindell (3-0) L: Dave Schmidt (0-1) S: Doug Jones (2) | Seventh | 9½ out |
| Sunday, April 17 |
| » Lost to Indians (11-2), 4-1 | Memorial Stadium (0-8) | 0-12 | Lost 12 |
| » W: John Farrell (2-0) L: Oswaldo Peraza (0-2) S: Dan Schatzeder (2) | Seventh | 10½ out |
| Tuesday, April 19 |
| » Lost to Brewers (5-7), 9-5 | County Stadium (0-1) | 0-13 | Lost 13 |
| » W: Juan Nieves (1-2) L: Mark Thurmond (0-3) S: Chuck Crim (1) | Sixth | 10½ out |
| Wednesday, April 20 |
| » Lost to Brewers (6-7), 8-6 | County Stadium (0-2) | 0-14 | Lost 14 |
| » W: Bill Wegman (1-2) L: Mike Boddicker (0-4) S: Dan Plesac (2) | Sixth | 11½ out |
| Thursday, April 21 |
| » Lost to Brewers (7-7), 7-1 | County Stadium (0-3) | 0-15 | Lost 15 |
| » W: Chris Bosio (3-1) L: Scott McGregor (0-3) | Fifth | 12 out |
| Friday, April 22 |
| » Lost to Royals (7-8), 13-1 | Royals Stadium (0-1) | 0-16 | Lost 16 |
| » W: Mark Gubicza (3-1) L: Mike Morgan (0-3) | Seventh | 13 out |
| Saturday, April 23 |
| » Lost to Royals (8-8), 4-3 | Royals Stadium (0-2) | 0-17 | Lost 17 |
| » W: Ted Power (1-0) L: Doug Sisk (0-1) | Seventh | 14 out |
| Sunday, April 24 |
| » Lost to Royals (9-8), 3-1 | Royals Stadium (0-3) | 0-18 | Lost 18 |
| » W: Bret Saberhagen (2-2) L: Mark Thurmond (0-4) | Seventh | 14 out |
| Tuesday, April 26 |
| » Lost to Twins (6-11), 4-2 | Hubert H. Humphrey Metrodome (0-1) | 0-19 | Lost 19 |
| » W: Frank Viola (2-1) L: Mike Morgan (0-4) S: Jeff Reardon (5) | Seventh | 15 out |
| » Major-league debuts: Craig Worthington (Orioles) |
| Wednesday, April 27 |
| » Lost to Twins (7-11), 7-6 | Hubert H. Humphrey Metrodome (0-2) | 0-20 | Lost 20 |
| » W: Juan Berenguer (3-2) L: Bill Scherrer (0-1) S: Keith Atherton (1) | Seventh | 16 out |
| Thursday, April 28 |
| » Lost to Twins (8-11), 4-2 | Hubert H. Humphrey Metrodome (0-3) | 0-21 | Lost 21 |
| » W: Allan Anderson (1-0) L: Mike Boddicker (0-5) S: Mark Portugal (1) | Seventh | 16 out |
| Friday, April 29 |
| » Defeated White Sox (10-10), 9-0 | Comiskey Park I (1-0) | 1-21 | |
| » W: Mark Williamson (1-0) L: Jack McDowell (1-2) S: Dave Schmidt (1) | Seventh | 15½ out |
| Saturday, April 30 |
| » Lost to White Sox (11-10), 4-1 | Comiskey Park I (1-1) | 1-22 | |
| » W: Ricky Horton (3-3) L: Mark Thurmond (0-5) S: Bobby Thigpen (4) | Seventh | 15½ out |
| Sunday, May 1 |
| » Lost to White Sox (12-10), 7-3 | Comiskey Park I (1-2) | 1-23 | Lost 2 |
| » W: Melido Perez (2-0) L: Mike Morgan (0-5) S: John Davis (1) | Seventh | 15½ out |
| Monday, May 2 |
| » Defeated Rangers (9-14), 9-4 | Memorial Stadium (1-8) | 2-23 | |
| » W: Jay Tibbs (1-0) L: Jose Guzman (3-2) | Seventh | 15½ out |
| Tuesday, May 3 |
| » Lost to Rangers (10-14), 4-2 | Memorial Stadium (1-9) | 2-24 | |
| » W: Ray Hayward (1-0) L: Mike Boddicker (0-6) S: Dale Mohorcic (2) | Seventh | 16 out |
| Wednesday, May 4 |
| » Defeated Twins (9-16), 4-3 | Memorial Stadium (2-9) | 3-24 | |
| » W: Dave Schmidt (1-1) L: Keith Atherton (0-1) | Seventh | 16 out |
| Saturday, May 7 |
| » Lost to White Sox (14-13), 11-7 | Memorial Stadium (2-10) | 3-25 | |
| » W: Bill Long (1-1) L: Jose Bautista (0-1) S: Bobby Thigpen (5) | Sixth | 16 out |
| Sunday, May 8 |
| » Defeated White Sox (14-14), 6-5 | Memorial Stadium (3-10) | 4-25 | |
| » W: Doug Sisk (1-1) L: Bobby Thigpen (0-3) | Seventh | 15 out |
| Monday, May 9 |
| » Lost to White Sox (15-14), 3-0 | Memorial Stadium (3-11) | 4-26 | |
| » W: Jerry Reuss (2-1) L: Mike Boddicker (0-7) S: Bobby Thigpen (6) | Seventh | 15½ out |
| Tuesday, May 10 |
| » Lost to Rangers (14-16), 13-5 | Arlington Stadium (0-1) | 4-27 | Lost 2 |
| » W: Charlie Hough (4-4) L: Mark Thurmond (0-6) | Seventh | 16½ out |
| Wednesday, May 11 |
| » Lost to Rangers (15-16), 8-0 | Arlington Stadium (0-2) | 4-28 | Lost 3 |
| » W: Paul Kilgus (5-2) L: Mark Williamson (1-1) | Seventh | 17½ out |
| Thursday, May 12 |
| » Lost to Rangers (16-16), 2-1 | Arlington Stadium (0-3) | 4-29 | Lost 4 |
| » W: Jose Guzman (4-2) L: Jose Bautista (0-2) S: Mitch Williams (7) | Seventh | 18 out |
| Friday, May 13 |
| » Defeated Athletics (24-10), 4-1 | Memorial Stadium (4-11) | 5-29 | |
| » W: Jay Tibbs (2-0) L: Dave Stewart (8-1) S: Tom Niedenfuer (1) | Seventh | 17 out |
| Saturday, May 14 |
| » Lost to Athletics (25-10), 8-0 | Memorial Stadium (4-12) | 5-30 | |
| » W: Bob Welch (6-2) L: Mike Boddicker (0-8) | Seventh | 18 out |
| Sunday, May 15 |
| » Lost to Athletics (26-10), 7-4 | Memorial Stadium (4-13) | 5-31 | Lost 2 |
| » W: Curt Young (3-1) L: Mark Williamson (1-2) S: Dennis Eckersley (13) | Seventh | 19 out |
| Wednesday, May 18 |
| » Defeated Angels (14-24), 8-7 | Memorial Stadium (5-13) | 6-31 | |
| » Manager: Elrod Hendricks |
| » W: Jose Bautista (1-2) L: Mike Witt (1-5) S: Tom Niedenfuer (2) | Seventh | 18½ out |
| Thursday, May 19 |
| » Lost to Angels (15-24), 2-1 | Memorial Stadium (5-14) | 6-32 | |
| » Manager: Frank Robinson |
| » W: Bryan Harvey (2-1) L: Dave Schmidt (1-2) | Seventh | 19½ out |
| » Lost to Angels (16-24), 9-6 | Memorial Stadium (5-15) | 6-33 | Lost 2 |
| » W: Stew Cliburn (1-0) L: Doug Sisk (1-2) S: Greg Minton (1) | Seventh | 19½ out |
| Friday, May 20 |
| » Lost to Mariners (18-23), 3-2 | Memorial Stadium (5-16) | 6-34 | Lost 3 |
| » W: Mark Langston (4-3) L: Mark Williamson (1-3) S: Mike Jackson (1) | Seventh | 19½ out |
| Saturday, May 21 |
| » Defeated Mariners (18-24), 3-1 | Memorial Stadium (6-16) | 7-34 | |
| » W: Jeff Ballard (1-0) L: Dennis Powell (1-2) S: Tom Niedenfuer (3) | Seventh | 19½ out |
| Sunday, May 22 |
| » Defeated Mariners (18-25), 7-2 | Memorial Stadium (7-16) | 8-34 | Won 2 |
| » W: Jose Bautista (2-2) L: Mike Moore (2-6) S: Mike Morgan (1) | Seventh | 19½ out |
| Monday, May 23 |
| » Defeated Athletics (29-14), 7-3 | Oakland-Alameda County Stadium (1-0) | 9-34 | Won 3 |
| » W: Mike Boddicker (1-8) L: Dave Stewart (8-3) S: Tom Niedenfuer (4) | Seventh | 19½ out |
| Tuesday, May 24 |
| » Lost to Athletics (30-14), 6-0 | Oakland-Alameda County Stadium (1-1) | 9-35 | |
| » W: Steve Ontiveros (3-1) L: Jay Tibbs (2-1) | Seventh | 20½ out |
| Wednesday, May 25 |
| » Lost to Athletics (31-14), 8-1 | Oakland-Alameda County Stadium (1-2) | 9-36 | Lost 2 |
| » W: Bob Welch (8-2) L: Mark Williamson (1-4) | Seventh | 21½ out |
| Friday, May 27 |
| » Lost to Angels (18-29), 4-2 | Anaheim Stadium (0-1) | 9-37 | Lost 3 |
| » W: Chuck Finley (3-6) L: Jeff Ballard (1-1) S: Bryan Harvey (3) | Seventh | 22½ out |
| Saturday, May 28 |
| » Lost to Angels (19-29), 5-0 | Anaheim Stadium (0-2) | 9-38 | Lost 4 |
| » W: Mike Witt (2-6) L: Jose Bautista (2-3) | Seventh | 22½ out |
| Sunday, May 29 |
| » Defeated Angels (19-30), 3-2 | Anaheim Stadium (1-2) | 10-38 | |
| » W: Mike Boddicker (2-8) L: Greg Minton (0-1) S: Tom Niedenfuer (5) | Seventh | 22½ out |
| Monday, May 30 |
| » Lost to Mariners (22-28), 4-1 | Kingdome (0-1) | 10-39 | |
| » W: Mark Langston (5-4) L: Jay Tibbs (2-2) S: Rod Scurry (1) | Seventh | 22½ out |
| Tuesday, May 31 |
| » Defeated Mariners (22-29), 12-5 | Kingdome (1-1) | 11-39 | |
| » W: Dave Schmidt (2-2) L: Edwin Nunez (1-2) | Seventh | 22½ out |
| Wednesday, June 1 |
| » Lost to Mariners (23-29), 4-3 | Kingdome (1-2) | 11-40 | |
| » W: Mike Jackson (2-1) L: Jeff Ballard (1-2) S: Rod Scurry (2) | Seventh | 22½ out |
| Friday, June 3 |
| » Lost to Yankees (34-17), 4-0 | Memorial Stadium (7-17) | 11-41 | Lost 2 |
| » W: Tommy John (4-1) L: Jose Bautista (2-4) | Seventh | 23½ out |
| Saturday, June 4 |
| » Defeated Yankees (34-18), 7-6 | Memorial Stadium (8-17) | 12-41 | |
| » W: Doug Sisk (2-2) L: Hipolito Pena (0-1) | Seventh | 22½ out |
| Sunday, June 5 |
| » Lost to Yankees (35-18), 9-2 | Memorial Stadium (8-18) | 12-42 | |
| » W: Richard Dotson (6-1) L: Jay Tibbs (2-3) | Seventh | 23½ out |
| Monday, June 6 |
| » Defeated Tigers (31-22), 5-2 | Memorial Stadium (9-18) | 13-42 | |
| » W: Jeff Ballard (2-2) L: Jack Morris (5-7) S: Tom Niedenfuer (6) | Seventh | 22½ out |
| Tuesday, June 7 |
| » Defeated Tigers (31-23), 4-3 | Memorial Stadium (10-18) | 14-42 | Won 2 |
| » W: Doug Sisk (3-2) L: Frank Tanana (8-4) | Seventh | 22½ out |
| Wednesday, June 8 |
| » Lost to Tigers (32-23), 12-4 | Memorial Stadium (10-19) | 14-43 | |
| » W: Paul Gibson (3-1) L: Jose Bautista (2-5) | Seventh | 22½ out |
| Friday, June 10 |
| » Defeated Yankees (36-21), 5-3 | Yankee Stadium (1-0) | 15-43 | |
| » W: Mike Boddicker (3-8) L: Rick Rhoden (2-5) | Seventh | 21½ out |
| Saturday, June 11 |
| » Lost to Yankees (37-21), 8-6 | Yankee Stadium (1-1) | 15-44 | |
| » W: John Candelaria (8-2) L: Jeff Ballard (2-3) S: Dave Righetti (10) | Seventh | 22½ out |
| Sunday, June 12 |
| » Lost to Yankees (38-21), 6-5 | Yankee Stadium (1-2) | 15-45 | Lost 2 |
| » W: Cecilio Guante (4-2) L: Tom Niedenfuer (0-1) | Seventh | 23½ out |
| Monday, June 13 |
| » Defeated Tigers (36-24), 6-4 | Tiger Stadium (1-0) | 16-45 | |
| » W: Tom Niedenfuer (1-1) L: Willie Hernandez (3-2) | Seventh | 23½ out |
| Tuesday, June 14 |
| » Lost to Tigers (37-24), 9-3 | Tiger Stadium (1-1) | 16-46 | |
| » W: Doyle Alexander (6-4) L: Dickie Noles (0-1) | Seventh | 23½ out |
| Wednesday, June 15 |
| » Lost to Tigers (38-24), 1-0 | Tiger Stadium (1-2) | 16-47 | Lost 2 |
| » W: Jeff Robinson (8-2) L: Mike Boddicker (3-9) | Seventh | 23½ out |
| Thursday, June 16 |
| » Defeated Red Sox (30-31), 8-4 | Memorial Stadium (11-19) | 17-47 | |
| » W: Jeff Ballard (3-3) L: John Trautwein (0-1) S: Mark Williamson (1) | Seventh | 23 out |
| Friday, June 17 |
| » Defeated Red Sox (30-32), 3-2 | Memorial Stadium (12-19) | 18-47 | Won 2 |
| » W: Dave Schmidt (3-2) L: Dennis Lamp (1-3) | Seventh | 22 out |
| Saturday, June 18 |
| » Lost to Red Sox (31-32), 5-0 | Memorial Stadium (12-20) | 18-48 | |
| » W: Roger Clemens (10-4) L: Jose Bautista (2-6) | Seventh | 23 out |
| Sunday, June 19 |
| » Lost to Red Sox (32-32), 15-7 | Memorial Stadium (12-21) | 18-49 | Lost 2 |
| » W: Wes Gardner (1-1) L: Dickie Noles (0-2) | Seventh | 23 out |
| Monday, June 20 |
| » Lost to Blue Jays (34-36), 5-2 | Exhibition Stadium (0-1) | 18-50 | Lost 3 |
| » W: Dave Stieb (10-3) L: Mike Boddicker (3-10) S: Tom Henke (13) | Seventh | 23½ out |
| Tuesday, June 21 |
| » Defeated Blue Jays (34-37), 4-2 | Exhibition Stadium (1-1) | 19-50 | |
| » W: Oswaldo Peraza (1-2) L: Mike Flanagan (6-5) S: Tom Niedenfuer (7) | Seventh | 23½ out |
| Wednesday, June 22 |
| » Lost to Blue Jays (35-37), 4-2 | Exhibition Stadium (1-2) | 19-51 | |
| » W: John Cerutti (4-3) L: Jeff Ballard (3-4) S: Duane Ward (5) | Seventh | 24½ out |
| Thursday, June 23 |
| » Lost to Blue Jays (36-37), 5-2 | Exhibition Stadium (1-3) | 19-52 | Lost 2 |
| » W: Jim Clancy (4-9) L: Jay Tibbs (2-4) S: David Wells (4) | Seventh | 25 out |
| Friday, June 24 |
| » Defeated Red Sox (34-34), 6-2 | Fenway Park (1-0) | 20-52 | |
| » W: Jose Bautista (3-6) L: Roger Clemens (10-5) | Seventh | 24 out |
| Saturday, June 25 |
| » Lost to Red Sox (35-34), 10-3 | Fenway Park (1-1) | 20-53 | |
| » W: Bob Stanley (3-0) L: Mark Williamson (1-5) | Seventh | 25 out |
| Sunday, June 26 |
| » Lost to Red Sox (36-34), 10-1 | Fenway Park (1-2) | 20-54 | Lost 2 |
| » W: Mike Smithson (3-2) L: Oswaldo Peraza (1-3) | Seventh | 25 out |
| Monday, June 27 |
| » Defeated Blue Jays (38-39), 6-2 | Memorial Stadium (13-21) | 21-54 | |
| » W: Jeff Ballard (4-4) L: John Cerutti (4-4) | Seventh | 25 out |
| Tuesday, June 28 |
| » Defeated Blue Jays (38-40), 7-0 | Memorial Stadium (14-21) | 22-54 | Won 2 |
| » W: Jay Tibbs (3-4) L: Jim Clancy (4-10) S: Mark Thurmond (1) | Seventh | 25 out |
| Wednesday, June 29 |
| » Lost to Blue Jays (39-40), 4-2 | Memorial Stadium (14-22) | 22-55 | |
| » W: Jimmy Key (3-1) L: Dave Schmidt (3-3) S: Tom Henke (16) | Seventh | 25 out |
| Friday, July 1 |
| » Defeated Rangers (37-40), 7-1 | Arlington Stadium (1-3) | 23-55 | |
| » W: Mike Boddicker (4-10) L: Jeff Russell (7-2) | Seventh | 25 out |
| Saturday, July 2 |
| » Defeated Rangers (37-41), 7-4 | Arlington Stadium (2-3) | 24-55 | Won 2 |
| » W: John Habyan (1-0) L: Paul Kilgus (7-7) S: Tom Niedenfuer (8) | Seventh | 25 out |
| Sunday, July 3 |
| » Lost to Rangers (38-41), 13-1 | Arlington Stadium (2-4) | 24-56 | |
| » W: Jose Guzman (8-6) L: Jeff Ballard (4-5) | Seventh | 25 out |
| Monday, July 4 |
| » Lost to White Sox (37-43), 5-1 | Comiskey Park I (1-3) | 24-57 | Lost 2 |
| » W: Melido Perez (7-5) L: Jay Tibbs (3-5) | Seventh | 26 out |
| Tuesday, July 5 |
| » Defeated White Sox (37-44), 5-1 | Comiskey Park I (2-3) | 25-57 | |
| » W: Jose Bautista (4-6) L: Dave LaPoint (6-9) | Seventh | 25 out |
| Wednesday, July 6 |
| » Lost to White Sox (38-44), 4-1 | Comiskey Park I (2-4) | 25-58 | |
| » W: Jack McDowell (4-6) L: Mike Boddicker (4-11) S: Ricky Horton (1) | Seventh | 26 out |
| Thursday, July 7 |
| » Defeated Rangers (39-44), 6-0 | Memorial Stadium (15-22) | 26-58 | |
| » W: Oswaldo Peraza (2-3) L: Paul Kilgus (7-8) | Seventh | 26 out |
| Friday, July 8 |
| » Lost to Rangers (40-44), 8-5 | Memorial Stadium (15-23) | 26-59 | |
| » W: Jose Guzman (9-6) L: Jeff Ballard (4-6) S: Craig McMurtry (1) | Seventh | 26 out |
| Saturday, July 9 |
| » Defeated Rangers (40-45), 4-1 | Memorial Stadium (16-23) | 27-59 | |
| » W: Jay Tibbs (4-5) L: Charlie Hough (8-9) S: Tom Niedenfuer (9) | Seventh | 26 out |
| Sunday, July 10 |
| » Defeated Rangers (40-46), 2-1 | Memorial Stadium (17-23) | 28-59 | Won 2 |
| » W: Jose Bautista (5-6) L: Bobby Witt (0-6) S: Dave Schmidt (2) | Seventh | 25 out |
| Thursday, July 14 |
| » Defeated Twins (47-39), 7-1 | Memorial Stadium (18-23) | 29-59 | Won 3 |
| » W: Mike Boddicker (5-11) L: Bert Blyleven (7-8) | Seventh | 24½ out |
| » Lost to Twins (48-39), 8-2 | Memorial Stadium (18-24) | 29-60 | |
| » W: Allan Anderson (6-6) L: Jay Tibbs (4-6) | Seventh | 24½ out |
| Friday, July 15 |
| » Lost to Twins (49-39), 4-2 | Memorial Stadium (18-25) | 29-61 | Lost 2 |
| » W: Charlie Lea (6-4) L: Jeff Ballard (4-7) S: Jeff Reardon (24) | Seventh | 24½ out |
| Saturday, July 16 |
| » Lost to Twins (50-39), 4-3 | Memorial Stadium (18-26) | 29-62 | Lost 3 |
| » W: Freddie Toliver (1-1) L: Oswaldo Peraza (2-4) S: Jeff Reardon (25) | Seventh | 25½ out |
| Sunday, July 17 |
| » Lost to Twins (51-39), 7-2 | Memorial Stadium (18-27) | 29-63 | Lost 4 |
| » W: Frank Viola (15-2) L: Jose Bautista (5-7) S: Mark Portugal (2) | Seventh | 25½ out |
| Tuesday, July 19 |
| » Defeated White Sox (42-50), 6-4 | Memorial Stadium (19-27) | 30-63 | |
| » W: Mike Boddicker (6-11) L: Jerry Reuss (6-7) S: Tom Niedenfuer (10) | Seventh | 25½ out |
| » Lost to White Sox (43-50), 2-0 | Memorial Stadium (19-28) | 30-64 | |
| » W: Bill Long (4-4) L: Jay Tibbs (4-7) S: Bobby Thigpen (20) | Seventh | 25½ out |
| Friday, July 22 |
| » Lost to Twins (52-42), 6-1 | Hubert H. Humphrey Metrodome (0-4) | 30-65 | Lost 2 |
| » W: Frank Viola (16-2) L: Jeff Ballard (4-8) | Seventh | 26 out |
| Saturday, July 23 |
| » Defeated Twins (52-43), 11-8 | Hubert H. Humphrey Metrodome (1-4) | 31-65 | |
| » W: Mike Morgan (1-5) L: Bert Blyleven (7-10) S: Tom Niedenfuer (11) | Sixth | 25 out |
| Sunday, July 24 |
| » Lost to Twins (53-43), 6-1 | Hubert H. Humphrey Metrodome (1-5) | 31-66 | |
| » W: Allan Anderson (7-7) L: Mike Boddicker (6-12) | Fifth | 25 out |
| Tuesday, July 26 |
| » Lost to Indians (50-50), 7-3 | Cleveland Stadium (0-5) | 31-67 | Lost 2 |
| » W: John Farrell (11-6) L: Jay Tibbs (4-8) S: Doug Jones (24) | Seventh | 26½ out |
| Wednesday, July 27 |
| » Lost to Indians (51-50), 12-2 | Cleveland Stadium (0-6) | 31-68 | Lost 3 |
| » W: Tom Candiotti (8-8) L: Jose Bautista (5-8) | Sixth | 27½ out |
| Thursday, July 28 |
| » Defeated Indians (51-51), 5-2 | Cleveland Stadium (1-6) | 32-68 | |
| » W: Oswaldo Peraza (3-4) L: Scott Bailes (7-10) S: Tom Niedenfuer (12) | Seventh | 27 out |
| Friday, July 29 |
| » Lost to Royals (50-52), 6-2 | Memorial Stadium (19-29) | 32-69 | |
| » W: Bret Saberhagen (11-10) L: Jeff Ballard (4-9) | Seventh | 27½ out |
| Saturday, July 30 |
| » Lost to Royals (51-52), 8-7 | Memorial Stadium (19-30) | 32-70 | Lost 2 |
| » W: Ted Power (5-4) L: Jay Tibbs (4-9) S: Steve Farr (11) | Seventh | 28½ out |
| Sunday, July 31 |
| » Lost to Royals (52-52), 4-1 | Memorial Stadium (19-31) | 32-71 | Lost 3 |
| » W: Charlie Leibrandt (6-11) L: Jose Bautista (5-9) | Seventh | 29½ out |
| Tuesday, August 2 |
| » Defeated Indians (52-54), 5-2 | Memorial Stadium (20-31) | 33-71 | |
| » W: Oswaldo Peraza (4-4) L: Scott Bailes (7-11) | Sixth | 29 out |
| Wednesday, August 3 |
| » Defeated Indians (52-55), 8-3 | Memorial Stadium (21-31) | 34-71 | Won 2 |
| » W: Jeff Ballard (5-9) L: Rick Rodriguez (1-2) | Sixth | 28 out |
| Thursday, August 4 |
| » Defeated Indians (52-56), 5-0 | Memorial Stadium (22-31) | 35-71 | Won 3 |
| » W: Dave Schmidt (4-3) L: Greg Swindell (12-10) | Seventh | 28 out |
| Friday, August 5 |
| » Defeated Brewers (54-55), 4-1 | Memorial Stadium (23-31) | 36-71 | Won 4 |
| » W: Jose Bautista (6-9) L: Teddy Higuera (7-8) | Seventh | 29 out |
| » Lost to Brewers (55-55), 3-1 | Memorial Stadium (23-32) | 36-72 | |
| » W: Don August (6-5) L: Mike Morgan (1-6) S: Dan Plesac (27) | Seventh | 29 out |
| Saturday, August 6 |
| » Defeated Brewers (55-56), 7-2 | Memorial Stadium (24-32) | 37-72 | |
| » W: Oswaldo Peraza (5-4) L: Tom Filer (5-5) | Seventh | 29 out |
| Sunday, August 7 |
| » Lost to Brewers (56-56), 7-2 | Memorial Stadium (24-33) | 37-73 | |
| » W: Mike Birkbeck (7-5) L: Jeff Ballard (5-10) | Seventh | 29 out |
| Monday, August 8 |
| » Major-league debuts: Rick Reed (Pirates) |
| Tuesday, August 9 |
| » Lost to Royals (57-55), 5-4 | Royals Stadium (0-4) | 37-74 | Lost 2 |
| » W: Israel Sanchez (1-1) L: Tom Niedenfuer (1-2) | Seventh | 29½ out |
| Wednesday, August 10 |
| » Lost to Royals (58-55), 4-3 | Royals Stadium (0-5) | 37-75 | Lost 3 |
| » W: Jeff Montgomery (4-2) L: Jose Bautista (6-10) S: Steve Farr (13) | Seventh | 30½ out |
| Thursday, August 11 |
| » Lost to Royals (59-55), 6-5 | Royals Stadium (0-6) | 37-76 | Lost 4 |
| » W: Jeff Montgomery (5-2) L: Tom Niedenfuer (1-3) | Seventh | 31 out |
| Friday, August 12 |
| » Lost to Brewers (60-57), 8-3 | County Stadium (0-4) | 37-77 | Lost 5 |
| » W: Mike Birkbeck (8-5) L: Oswaldo Peraza (5-5) | Seventh | 31 out |
| Saturday, August 13 |
| » Defeated Brewers (60-58), 5-0 | County Stadium (1-4) | 38-77 | |
| » W: Jeff Ballard (6-10) L: Tom Filer (5-6) | Sixth | 30 out |
| Sunday, August 14 |
| » Defeated Brewers (60-59), 11-9 | County Stadium (2-4) | 39-77 | Won 2 |
| » W: Dave Schmidt (5-3) L: Juan Nieves (4-5) S: Mark Thurmond (2) | Sixth | 30 out |
| Monday, August 15 |
| » Lost to Brewers (61-59), 4-1 | County Stadium (2-5) | 39-78 | |
| » W: Teddy Higuera (9-8) L: Jose Bautista (6-11) S: Dan Plesac (28) | Seventh | 30 out |
| Tuesday, August 16 |
| » Lost to Athletics (76-44), 6-3 | Memorial Stadium (24-34) | 39-79 | Lost 2 |
| » W: Storm Davis (12-4) L: Jay Tibbs (4-10) S: Dennis Eckersley (34) | Seventh | 30 out |
| Wednesday, August 17 |
| » Lost to Athletics (77-44), 10-4 | Memorial Stadium (24-35) | 39-80 | Lost 3 |
| » W: Curt Young (7-7) L: Doug Sisk (3-3) S: Eric Plunk (4) | Seventh | 30 out |
| Thursday, August 18 |
| » Defeated Athletics (77-45), 10-1 | Memorial Stadium (25-35) | 40-80 | |
| » W: Jeff Ballard (7-10) L: Bob Welch (14-7) | Seventh | 30 out |
| Friday, August 19 |
| » Defeated Angels (61-61), 3-1 | Memorial Stadium (26-35) | 41-80 | Won 2 |
| » W: Dave Schmidt (6-3) L: Mike Witt (9-12) S: Tom Niedenfuer (13) | Seventh | 30 out |
| Saturday, August 20 |
| » Defeated Angels (61-62), 3-2 | Memorial Stadium (27-35) | 42-80 | Won 3 |
| » W: Mark Williamson (2-5) L: Greg Minton (3-3) | Seventh | 30 out |
| Sunday, August 21 |
| » Lost to Angels (62-62), 3-2 | Memorial Stadium (27-36) | 42-81 | |
| » W: Willie Fraser (10-10) L: Jay Tibbs (4-11) S: Sherman Corbett (1) | Seventh | 31 out |
| Monday, August 22 |
| » Lost to Mariners (51-75), 7-3 | Memorial Stadium (27-37) | 42-82 | Lost 2 |
| » W: Bill Wilkinson (1-2) L: Oswaldo Peraza (5-6) | Seventh | 31 out |
| Wednesday, August 24 |
| » Defeated Mariners (51-76), 4-3 | Memorial Stadium (28-37) | 43-82 | |
| » W: Mark Williamson (3-5) L: Mike Schooler (4-6) | Seventh | 29 out |
| » Defeated Mariners (51-77), 4-3 | Memorial Stadium (29-37) | 44-82 | Won 2 |
| » W: Tom Niedenfuer (2-3) L: Rod Scurry (0-2) | Seventh | 29 out |
| Thursday, August 25 |
| » Major-league debuts: Keith Brown (Reds) |
| Friday, August 26 |
| » Lost to Athletics (80-49), 8-5 | Oakland-Alameda County Stadium (1-3) | 44-83 | |
| » W: Storm Davis (13-4) L: Jay Tibbs (4-12) S: Eric Plunk (5) | Seventh | 30 out |
| Saturday, August 27 |
| » Lost to Athletics (81-49), 5-1 | Oakland-Alameda County Stadium (1-4) | 44-84 | Lost 2 |
| » W: Todd Burns (6-1) L: Oswaldo Peraza (5-7) S: Greg Cadaret (3) | Seventh | 30 out |
| Sunday, August 28 |
| » Defeated Athletics (81-50), 2-1 | Oakland-Alameda County Stadium (2-4) | 45-84 | |
| » W: Mark Williamson (4-5) L: Gene Nelson (7-6) S: Tom Niedenfuer (14) | Seventh | 29 out |
| Monday, August 29 |
| » Lost to Angels (67-64), 4-2 | Anaheim Stadium (1-3) | 45-85 | |
| » W: Mike Witt (11-12) L: Jeff Ballard (7-11) | Seventh | 29 out |
| Tuesday, August 30 |
| » Defeated Angels (67-65), 5-2 | Anaheim Stadium (2-3) | 46-85 | |
| » W: Dave Schmidt (7-3) L: Dan Petry (3-6) S: Tom Niedenfuer (15) | Seventh | 28 out |
| Wednesday, August 31 |
| » Lost to Angels (68-65), 7-5 | Anaheim Stadium (2-4) | 46-86 | |
| » W: Bryan Harvey (6-4) L: Mark Williamson (4-6) | Seventh | 29 out |
| Friday, September 2 |
| » Defeated Mariners (54-81), 4-3 | Kingdome (2-2) | 47-86 | |
| » W: Gregg Olson (1-0) L: Mike Schooler (4-7) S: Tom Niedenfuer (16) | Seventh | 27½ out |
| » Major-league debuts: Gregg Olson (Orioles) |
| Saturday, September 3 |
| » Lost to Mariners (55-81), 1-0 | Kingdome (2-3) | 47-87 | |
| » W: Mark Langston (11-10) L: Jose Bautista (6-12) | Seventh | 27½ out |
| Sunday, September 4 |
| » Defeated Mariners (55-82), 6-4 | Kingdome (3-3) | 48-87 | |
| » W: Mark Williamson (5-6) L: Terry Taylor (0-1) S: Tom Niedenfuer (17) | Sixth | 26½ out |
| Monday, September 5 |
| » Lost to Red Sox (76-61), 4-1 | Memorial Stadium (29-38) | 48-88 | |
| » W: Mike Smithson (7-5) L: Dave Schmidt (7-4) S: Lee Smith (23) | Seventh | 27½ out |
| Tuesday, September 6 |
| » Lost to Red Sox (77-61), 6-1 | Memorial Stadium (29-39) | 48-89 | Lost 2 |
| » W: Wes Gardner (7-4) L: Jay Tibbs (4-13) | Seventh | 28½ out |
| Wednesday, September 7 |
| » Defeated Red Sox (77-62), 4-3 | Memorial Stadium (30-39) | 49-89 | |
| » W: Mark Thurmond (1-6) L: Bob Stanley (6-3) | Seventh | 27½ out |
| » Major-league debuts: Curt Schilling (Orioles) |
| Friday, September 9 |
| » Lost to Blue Jays (72-69), 8-1 | Memorial Stadium (30-40) | 49-90 | |
| » W: Jim Clancy (9-13) L: Jose Bautista (6-13) | Seventh | 28½ out |
| Saturday, September 10 |
| » Defeated Blue Jays (72-70), 7-4 | Memorial Stadium (31-40) | 50-90 | |
| » W: Jeff Ballard (8-11) L: Jeff Musselman (5-4) S: Mark Williamson (2) | Seventh | 28½ out |
| Sunday, September 11 |
| » Defeated Blue Jays (72-71), 4-2 | Memorial Stadium (32-40) | 51-90 | Won 2 |
| » W: Dave Schmidt (8-4) L: Mike Flanagan (11-13) S: Mark Thurmond (3) | Seventh | 27½ out |
| Monday, September 12 |
| » Lost to Red Sox (80-63), 6-1 | Fenway Park (1-3) | 51-91 | |
| » W: Bruce Hurst (17-5) L: Curt Schilling (0-1) | Seventh | 28½ out |
| Tuesday, September 13 |
| » Lost to Red Sox (81-63), 6-4 | Fenway Park (1-4) | 51-92 | Lost 2 |
| » W: Mike Smithson (8-5) L: Pete Harnisch (0-1) S: Lee Smith (25) | Seventh | 29½ out |
| » Major-league debuts: Pete Harnisch (Orioles) |
| Wednesday, September 14 |
| » Lost to Red Sox (82-63), 4-3 | Fenway Park (1-5) | 51-93 | Lost 3 |
| » W: Mike Boddicker (12-15) L: Jose Bautista (6-14) S: Lee Smith (26) | Seventh | 30½ out |
| Friday, September 16 |
| » Lost to Tigers (78-69), 8-7 | Tiger Stadium (1-3) | 51-94 | Lost 4 |
| » W: Willie Hernandez (6-5) L: Mark Thurmond (1-7) | Seventh | 31 out |
| Saturday, September 17 |
| » Lost to Tigers (79-69), 7-3 | Tiger Stadium (1-4) | 51-95 | Lost 5 |
| » W: Doyle Alexander (12-11) L: Gregg Olson (1-1) S: Mike Henneman (20) | Seventh | 32 out |
| Sunday, September 18 |
| » Defeated Tigers (79-70), 2-0 | Tiger Stadium (2-4) | 52-95 | |
| » W: Bob Milacki (1-0) L: Frank Tanana (14-10) S: Tom Niedenfuer (18) | Seventh | 32 out |
| » Major-league debuts: Bob Milacki (Orioles) |
| Monday, September 19 |
| » Lost to Yankees (79-70), 3-2 | Yankee Stadium (1-3) | 52-96 | |
| » W: Richard Dotson (11-9) L: Pete Harnisch (0-2) S: Dave Righetti (23) | Seventh | 32 out |
| Tuesday, September 20 |
| » Lost to Yankees (80-70), 7-1 | Yankee Stadium (1-4) | 52-97 | Lost 2 |
| » W: Rick Rhoden (12-10) L: Jose Bautista (6-15) | Seventh | 33 out |
| Wednesday, September 21 |
| » Lost to Yankees |