| Monday, April 4 |
| » Lost to Athletics (1-0), 4-1 | Oakland-Alameda County Stadium (0-1) | 0-1 | |
| » W: Dave Stewart (1-0) L: Mark Langston (0-1) S: Dennis Eckersley (1) | Third | 1 out |
| Tuesday, April 5 |
| » Lost to Athletics (2-0), 6-0 | Oakland-Alameda County Stadium (0-2) | 0-2 | Lost 2 |
| » W: Bob Welch (1-0) L: Mike Moore (0-1) S: Dennis Eckersley (2) | Fourth | 2 out |
| Wednesday, April 6 |
| » Defeated Athletics (2-1), 6-5 | Oakland-Alameda County Stadium (1-2) | 1-2 | |
| » W: Bill Swift (1-0) L: Gene Nelson (0-1) S: Julio Solano (1) | Third | 1 out |
| Friday, April 8 |
| » Lost to White Sox (3-1), 3-2 | Comiskey Park I (0-1) | 1-3 | |
| » W: John Davis (1-0) L: Bill Wilkinson (0-1) | Fourth | 2 out |
| Saturday, April 9 |
| » Defeated White Sox (3-2), 3-2 | Comiskey Park I (1-1) | 2-3 | |
| » W: Jerry Reed (1-0) L: Ricky Horton (1-1) | Third | 2 out |
| Sunday, April 10 |
| » Defeated White Sox (3-3), 7-4 | Comiskey Park I (2-1) | 3-3 | Won 2 |
| » W: Mike Moore (1-1) L: Jerry Reuss (0-1) | Second | 1 out |
| Tuesday, April 12 |
| » Defeated Athletics (4-3), 6-4 | Kingdome (1-0) | 4-3 | Won 3 |
| » W: Steve Trout (1-0) L: Gene Nelson (0-2) S: Jerry Reed (1) | First | -- |
| Wednesday, April 13 |
| » Lost to Athletics (5-3), 12-7 | Kingdome (1-1) | 4-4 | |
| » W: Steve Ontiveros (1-0) L: Mike Campbell (0-1) S: Rick Honeycutt (1) | Second | 1 out |
| Thursday, April 14 |
| » Lost to Athletics (6-3), 5-4 | Kingdome (1-2) | 4-5 | Lost 2 |
| » W: Dave Stewart (3-0) L: Jerry Reed (1-1) S: Dennis Eckersley (4) | Third | 2 out |
| Friday, April 15 |
| » Lost to Angels (5-4), 5-3 | Kingdome (1-3) | 4-6 | Lost 3 |
| » W: Mike Witt (1-1) L: Bill Wilkinson (0-2) | Fifth | 2½ out |
| Saturday, April 16 |
| » Defeated Angels (5-5), 7-6 | Kingdome (2-3) | 5-6 | |
| » W: Edwin Nunez (1-0) L: De Wayne Buice (0-1) | Fourth | 1½ out |
| Sunday, April 17 |
| » Lost to Angels (6-5), 7-4 | Kingdome (2-4) | 5-7 | |
| » W: Kirk McCaskill (1-1) L: Steve Trout (1-1) S: Ray Krawczyk (1) | Fourth | 1½ out |
| Monday, April 18 |
| » Lost to White Sox (7-5), 4-0 | Kingdome (2-5) | 5-8 | Lost 2 |
| » W: Dave LaPoint (2-1) L: Mike Campbell (0-2) | Fifth | 2½ out |
| Tuesday, April 19 |
| » Lost to White Sox (8-5), 7-2 | Kingdome (2-6) | 5-9 | Lost 3 |
| » W: Jerry Reuss (1-1) L: Mark Langston (0-2) | Fourth | 3½ out |
| Wednesday, April 20 |
| » Defeated White Sox (8-6), 5-4 | Kingdome (3-6) | 6-9 | |
| » W: Mike Moore (2-1) L: Ricky Horton (2-2) | Fourth | 3 out |
| Thursday, April 21 |
| » Lost to Angels (7-8), 11-6 | Anaheim Stadium (0-1) | 6-10 | |
| » W: Willie Fraser (2-0) L: Edwin Nunez (1-1) | Fifth | 4 out |
| Friday, April 22 |
| » Defeated Angels (7-9), 7-4 | Anaheim Stadium (1-1) | 7-10 | |
| » W: Steve Trout (2-1) L: Kirk McCaskill (1-2) S: Bill Wilkinson (1) | Fifth | 3 out |
| Saturday, April 23 |
| » Defeated Angels (7-10), 11-4 | Anaheim Stadium (2-1) | 8-10 | Won 2 |
| » W: Mike Campbell (1-2) L: Dan Petry (1-1) | Fourth | 3 out |
| Sunday, April 24 |
| » Defeated Angels (7-11), 4-2 | Anaheim Stadium (3-1) | 9-10 | Won 3 |
| » W: Mark Langston (1-2) L: Chuck Finley (1-3) | Fourth | 3 out |
| Tuesday, April 26 |
| » Lost to Indians (15-4), 12-6 | Cleveland Stadium (0-1) | 9-11 | |
| » W: Tom Candiotti (4-0) L: Mike Moore (2-2) | Third | 4 out |
| Wednesday, April 27 |
| » Lost to Indians (16-4), 6-4 | Cleveland Stadium (0-2) | 9-12 | Lost 2 |
| » W: Greg Swindell (5-0) L: Steve Trout (2-2) S: Doug Jones (4) | Fourth | 5 out |
| Thursday, April 28 |
| » Defeated Indians (16-5), 3-1 | Cleveland Stadium (1-2) | 10-12 | |
| » W: Mike Campbell (2-2) L: John Farrell (3-1) | Fourth | 5 out |
| Friday, April 29 |
| » Lost to Tigers (12-8), 9-6 | Tiger Stadium (0-1) | 10-13 | |
| » W: Willie Hernandez (1-1) L: Mark Langston (1-3) S: Don Heinkel (1) | Fourth | 5½ out |
| Saturday, April 30 |
| » Lost to Tigers (13-8), 4-3 | Tiger Stadium (0-2) | 10-14 | Lost 2 |
| » W: Paul Gibson (1-0) L: Mike Jackson (0-1) | Fifth | 6½ out |
| Sunday, May 1 |
| » Lost to Tigers (14-8), 3-2 | Tiger Stadium (0-3) | 10-15 | Lost 3 |
| » W: Jeff Robinson (3-2) L: Mike Moore (2-3) S: Willie Hernandez (1) | Sixth | 7½ out |
| Monday, May 2 |
| » Defeated Blue Jays (10-14), 7-5 | Kingdome (4-6) | 11-15 | |
| » W: Steve Trout (3-2) L: Mike Flanagan (2-2) S: Julio Solano (2) | Fourth | 7½ out |
| Tuesday, May 3 |
| » Lost to Blue Jays (11-14), 9-2 | Kingdome (4-7) | 11-16 | |
| » W: Todd Stottlemyre (1-2) L: Mike Campbell (2-3) S: Duane Ward (2) | Sixth | 8½ out |
| Wednesday, May 4 |
| » Defeated Indians (17-9), 5-4 | Kingdome (5-7) | 12-16 | |
| » W: Mark Langston (2-3) L: Scott Bailes (1-3) S: Julio Solano (3) | Fourth | 8½ out |
| Thursday, May 5 |
| » Defeated Indians (17-10), 7-2 | Kingdome (6-7) | 13-16 | Won 2 |
| » W: Bill Swift (2-0) L: Rich Yett (2-2) | Fourth | 8½ out |
| Friday, May 6 |
| » Lost to Tigers (17-10), 8-4 | Kingdome (6-8) | 13-17 | |
| » W: Jeff Robinson (4-2) L: Dennis Powell (0-1) S: Mike Henneman (10) | Fourth | 9 out |
| Saturday, May 7 |
| » Defeated Tigers (17-11), 7-6 | Kingdome (7-8) | 14-17 | |
| » W: Dennis Powell (1-1) L: Paul Gibson (1-1) S: Bill Wilkinson (2) | Fourth | 9 out |
| Sunday, May 8 |
| » Lost to Tigers (18-11), 9-3 | Kingdome (7-9) | 14-18 | |
| » W: Frank Tanana (6-1) L: Mike Campbell (2-4) | Fifth | 10 out |
| Tuesday, May 10 |
| » Defeated Blue Jays (13-18), 4-2 | Exhibition Stadium (1-0) | 15-18 | |
| » W: Mark Langston (3-3) L: Jim Clancy (1-4) | Fifth | 9½ out |
| Wednesday, May 11 |
| » Lost to Blue Jays (14-18), 9-3 | Exhibition Stadium (1-1) | 15-19 | |
| » W: Dave Stieb (4-3) L: Mike Moore (2-4) | Fourth | 9½ out |
| Thursday, May 12 |
| » Lost to Blue Jays (15-18), 8-2 | Exhibition Stadium (1-2) | 15-20 | Lost 2 |
| » W: Mike Flanagan (4-2) L: Bill Swift (2-1) | Fifth | 10 out |
| Friday, May 13 |
| » Lost to Red Sox (18-13), 14-8 | Fenway Park (0-1) | 15-21 | Lost 3 |
| » W: Oil Can Boyd (4-2) L: Mike Campbell (2-5) S: Wes Gardner (2) | Fifth | 10 out |
| Saturday, May 14 |
| » Lost to Red Sox (19-13), 3-0 | Fenway Park (0-2) | 15-22 | Lost 4 |
| » W: Roger Clemens (6-1) L: Scott Bankhead (0-1) | Sixth | 11 out |
| Sunday, May 15 |
| » Defeated Red Sox (19-14), 11-7 | Fenway Park (1-2) | 16-22 | |
| » W: Mike Jackson (1-1) L: Lee Smith (2-2) | Sixth | 11 out |
| Monday, May 16 |
| » Lost to Yankees (25-12), 3-1 | Yankee Stadium (0-1) | 16-23 | |
| » W: John Candelaria (5-2) L: Mike Moore (2-5) S: Dave Righetti (6) | Sixth | 12 out |
| Tuesday, May 17 |
| » Defeated Yankees (25-13), 6-2 | Yankee Stadium (1-1) | 17-23 | |
| » W: Bill Swift (3-1) L: Richard Dotson (5-1) | Sixth | 12 out |
| » Major-league debuts: Bob Geren (Yankees) |
| Friday, May 20 |
| » Defeated Orioles (6-34), 3-2 | Memorial Stadium (1-0) | 18-23 | Won 2 |
| » W: Mark Langston (4-3) L: Mark Williamson (1-3) S: Mike Jackson (1) | Fifth | 11½ out |
| Saturday, May 21 |
| » Lost to Orioles (7-34), 3-1 | Memorial Stadium (1-1) | 18-24 | |
| » W: Jeff Ballard (1-0) L: Dennis Powell (1-2) S: Tom Niedenfuer (3) | Fifth | 11½ out |
| Sunday, May 22 |
| » Lost to Orioles (8-34), 7-2 | Memorial Stadium (1-2) | 18-25 | Lost 2 |
| » W: Jose Bautista (2-2) L: Mike Moore (2-6) S: Mike Morgan (1) | Sixth | 11½ out |
| Monday, May 23 |
| » Defeated Red Sox (22-18), 14-3 | Kingdome (8-9) | 19-25 | |
| » W: Bill Swift (4-1) L: Oil Can Boyd (5-3) | Sixth | 10½ out |
| Tuesday, May 24 |
| » Defeated Red Sox (22-19), 14-1 | Kingdome (9-9) | 20-25 | Won 2 |
| » W: Mike Campbell (3-5) L: Mike Smithson (0-1) | Fifth | 10½ out |
| Wednesday, May 25 |
| » Lost to Red Sox (23-19), 4-0 | Kingdome (9-10) | 20-26 | |
| » W: Roger Clemens (7-2) L: Mark Langston (4-4) | Fifth | 11½ out |
| Friday, May 27 |
| » Lost to Yankees (31-14), 5-1 | Kingdome (9-11) | 20-27 | Lost 2 |
| » W: Tommy John (3-1) L: Scott Bankhead (0-2) S: Cecilio Guante (4) | Fifth | 12½ out |
| Saturday, May 28 |
| » Defeated Yankees (31-15), 6-1 | Kingdome (10-11) | 21-27 | |
| » W: Bill Swift (5-1) L: Rick Rhoden (2-4) | Fifth | 12½ out |
| Sunday, May 29 |
| » Lost to Yankees (32-15), 7-3 | Kingdome (10-12) | 21-28 | |
| » W: John Candelaria (7-2) L: Mike Campbell (3-6) S: Cecilio Guante (5) | Fifth | 13½ out |
| Monday, May 30 |
| » Defeated Orioles (10-39), 4-1 | Kingdome (11-12) | 22-28 | |
| » W: Mark Langston (5-4) L: Jay Tibbs (2-2) S: Rod Scurry (1) | Fifth | 13½ out |
| Tuesday, May 31 |
| » Lost to Orioles (11-39), 12-5 | Kingdome (11-13) | 22-29 | |
| » W: Dave Schmidt (2-2) L: Edwin Nunez (1-2) | Sixth | 13½ out |
| Wednesday, June 1 |
| » Defeated Orioles (11-40), 4-3 | Kingdome (12-13) | 23-29 | |
| » W: Mike Jackson (2-1) L: Jeff Ballard (1-2) S: Rod Scurry (2) | Fifth | 13½ out |
| Thursday, June 2 |
| » Lost to Royals (24-28), 3-0 | Royals Stadium (0-1) | 23-30 | |
| » W: Ted Power (2-1) L: Bill Swift (5-2) | Fifth | 14 out |
| Friday, June 3 |
| » Lost to Royals (25-28), 3-1 | Royals Stadium (0-2) | 23-31 | Lost 2 |
| » W: Bret Saberhagen (7-5) L: Mike Campbell (3-7) | Fifth | 15 out |
| Saturday, June 4 |
| » Lost to Royals (26-28), 4-3 | Royals Stadium (0-3) | 23-32 | Lost 3 |
| » W: Steve Farr (1-0) L: Mark Langston (5-5) | Sixth | 16 out |
| Sunday, June 5 |
| » Lost to Royals (27-28), 7-3 | Royals Stadium (0-4) | 23-33 | Lost 4 |
| » W: Mark Gubicza (7-5) L: Edwin Nunez (1-3) | Sixth | 16 out |
| Monday, June 6 |
| » Defeated Brewers (29-27), 2-0 | Kingdome (13-13) | 24-33 | |
| » Manager: Jim Snyder |
| » W: Scott Bankhead (1-2) L: Don August (1-1) S: Mike Moore (1) | Sixth | 15 out |
| Tuesday, June 7 |
| » Defeated Brewers (29-28), 5-4 | Kingdome (14-13) | 25-33 | Won 2 |
| » W: Mike Moore (3-6) L: Paul Mirabella (0-1) | Sixth | 14 out |
| Wednesday, June 8 |
| » Lost to Brewers (30-28), 8-7 | Kingdome (14-14) | 25-34 | |
| » W: Mark Clear (1-0) L: Mike Jackson (2-2) S: Dan Plesac (13) | Sixth | 14 out |
| Thursday, June 9 |
| » Lost to Twins (30-26), 7-5 | Kingdome (14-15) | 25-35 | Lost 2 |
| » W: Bert Blyleven (4-6) L: Mark Langston (5-6) S: Jeff Reardon (15) | Sixth | 14 out |
| Friday, June 10 |
| » Lost to Twins (31-26), 3-1 | Kingdome (14-16) | 25-36 | Lost 3 |
| » W: Allan Anderson (3-3) L: Edwin Nunez (1-4) S: Jeff Reardon (16) | Sixth | 15 out |
| » Major-league debuts: Mike Schooler (Mariners) |
| Saturday, June 11 |
| » Defeated Twins (31-27), 3-2 | Kingdome (15-16) | 26-36 | |
| » W: Mike Jackson (3-2) L: Frank Viola (9-2) S: Mike Schooler (1) | Sixth | 15 out |
| Sunday, June 12 |
| » Lost to Twins (32-27), 6-2 | Kingdome (15-17) | 26-37 | |
| » W: Charlie Lea (2-3) L: Bill Swift (5-3) | Sixth | 15 out |
| Monday, June 13 |
| » Lost to Brewers (32-30), 3-1 | County Stadium (0-1) | 26-38 | Lost 2 |
| » W: Bill Wegman (5-5) L: Mike Campbell (3-8) S: Dan Plesac (14) | Sixth | 15½ out |
| Tuesday, June 14 |
| » Lost to Brewers (33-30), 5-1 | County Stadium (0-2) | 26-39 | Lost 3 |
| » W: Tom Filer (4-0) L: Mike Moore (3-7) | Sixth | 15½ out |
| Wednesday, June 15 |
| » Lost to Brewers (34-30), 5-1 | County Stadium (0-3) | 26-40 | Lost 4 |
| » W: Teddy Higuera (6-4) L: Mark Langston (5-7) S: Dan Plesac (15) | Sixth | 15½ out |
| Friday, June 17 |
| » Lost to Twins (35-28), 4-1 | Hubert H. Humphrey Metrodome (0-1) | 26-41 | Lost 5 |
| » W: Frank Viola (10-2) L: Scott Bankhead (1-3) S: Jeff Reardon (18) | Seventh | 16 out |
| Saturday, June 18 |
| » Lost to Twins (36-28), 6-2 | Hubert H. Humphrey Metrodome (0-2) | 26-42 | Lost 6 |
| » W: Charlie Lea (3-3) L: Bill Swift (5-4) S: Jeff Reardon (19) | Seventh | 17 out |
| Sunday, June 19 |
| » Lost to Twins (37-28), 3-1 | Hubert H. Humphrey Metrodome (0-3) | 26-43 | Lost 7 |
| » W: Bert Blyleven (6-6) L: Mike Moore (3-8) S: Jeff Reardon (20) | Seventh | 17 out |
| Monday, June 20 |
| » Lost to Rangers (33-35), 4-3 | Arlington Stadium (0-1) | 26-44 | Lost 8 |
| » W: Jeff Russell (7-0) L: Mike Schooler (0-1) | Seventh | 18 out |
| Tuesday, June 21 |
| » Lost to Rangers (34-35), 6-0 | Arlington Stadium (0-2) | 26-45 | Lost 9 |
| » W: Paul Kilgus (7-5) L: Steve Trout (3-3) | Seventh | 19 out |
| Wednesday, June 22 |
| » Defeated Rangers (34-36), 3-2 | Arlington Stadium (1-2) | 27-45 | |
| » W: Mike Schooler (1-1) L: Jose Guzman (6-6) | Seventh | 19 out |
| Friday, June 24 |
| » Defeated Royals (37-35), 7-0 | Kingdome (16-17) | 28-45 | Won 2 |
| » W: Mike Moore (4-8) L: Floyd Bannister (7-6) | Seventh | 18 out |
| Saturday, June 25 |
| » Lost to Royals (38-35), 7-3 | Kingdome (16-18) | 28-46 | |
| » W: Bret Saberhagen (10-6) L: Mark Langston (5-8) | Seventh | 19 out |
| Sunday, June 26 |
| » Defeated Royals (38-36), 8-0 | Kingdome (17-18) | 29-46 | |
| » W: Bill Swift (6-4) L: Charlie Leibrandt (3-10) | Seventh | 17½ out |
| Monday, June 27 |
| » Defeated Rangers (35-39), 6-3 | Kingdome (18-18) | 30-46 | Won 2 |
| » W: Scott Bankhead (2-3) L: Paul Kilgus (7-6) S: Mike Schooler (2) | Seventh | 17½ out |
| » Major-league debuts: Greg Briley (Mariners) |
| Tuesday, June 28 |
| » Lost to Rangers (36-39), 6-0 | Kingdome (18-19) | 30-47 | |
| » W: Jose Guzman (7-6) L: Steve Trout (3-4) | Seventh | 17½ out |
| Wednesday, June 29 |
| » Lost to Rangers (37-39), 1-0 | Kingdome (18-20) | 30-48 | Lost 2 |
| » W: Charlie Hough (8-7) L: Mike Schooler (1-2) S: Mitch Williams (11) | Seventh | 18½ out |
| Friday, July 1 |
| » Defeated Indians (41-37), 11-3 | Cleveland Stadium (2-2) | 31-48 | |
| » W: Mark Langston (6-8) L: Greg Swindell (10-7) S: Mike Jackson (2) | Seventh | 18½ out |
| Saturday, July 2 |
| » Lost to Indians (42-37), 10-7 | Cleveland Stadium (2-3) | 31-49 | |
| » W: John Farrell (9-5) L: Bill Swift (6-5) S: Doug Jones (19) | Seventh | 19½ out |
| Sunday, July 3 |
| » Defeated Indians (42-38), 7-6 | Cleveland Stadium (3-3) | 32-49 | |
| » W: Scott Bankhead (3-3) L: Jon Perlman (0-2) S: Mike Schooler (3) | Seventh | 19½ out |
| Monday, July 4 |
| » Lost to Tigers (49-30), 5-3 | Tiger Stadium (0-4) | 32-50 | |
| » W: Mike Henneman (3-2) L: Rod Scurry (0-1) S: Eric King (2) | Seventh | 20½ out |
| Tuesday, July 5 |
| » Defeated Tigers (49-31), 5-4 | Tiger Stadium (1-4) | 33-50 | |
| » W: Steve Trout (4-4) L: Walt Terrell (3-6) S: Mike Schooler (4) | Seventh | 19 out |
| Wednesday, July 6 |
| » Lost to Tigers (50-31), 7-6 | Tiger Stadium (1-5) | 33-51 | |
| » W: Mike Henneman (4-2) L: Mike Schooler (1-3) | Seventh | 19 out |
| Friday, July 8 |
| » Lost to Blue Jays (41-45), 3-2 | Exhibition Stadium (1-3) | 33-52 | Lost 2 |
| » W: Mike Flanagan (8-6) L: Bill Swift (6-6) S: Duane Ward (7) | Seventh | 19½ out |
| Saturday, July 9 |
| » Defeated Blue Jays (41-46), 9-3 | Exhibition Stadium (2-3) | 34-52 | |
| » W: Scott Bankhead (4-3) L: Todd Stottlemyre (3-8) | Sixth | 18½ out |
| Sunday, July 10 |
| » Lost to Blue Jays (42-46), 5-0 | Exhibition Stadium (2-4) | 34-53 | |
| » W: Jimmy Key (5-1) L: Mike Moore (4-9) | Sixth | 19½ out |
| Thursday, July 14 |
| » Defeated Indians (45-44), 3-1 | Kingdome (19-20) | 35-53 | |
| » W: Mark Langston (7-8) L: Greg Swindell (10-8) | Seventh | 18½ out |
| Friday, July 15 |
| » Defeated Indians (45-45), 8-5 | Kingdome (20-20) | 36-53 | Won 2 |
| » W: Mike Jackson (4-2) L: Brad Havens (1-2) S: Mike Schooler (5) | Seventh | 17½ out |
| Saturday, July 16 |
| » Lost to Indians (46-45), 8-2 | Kingdome (20-21) | 36-54 | |
| » W: Bud Black (4-3) L: Scott Bankhead (4-4) S: Doug Jones (21) | Seventh | 18½ out |
| Sunday, July 17 |
| » Lost to Indians (47-45), 7-4 | Kingdome (20-22) | 36-55 | Lost 2 |
| » W: Don Gordon (2-0) L: Bill Swift (6-7) S: Doug Jones (22) | Seventh | 18½ out |
| Monday, July 18 |
| » Lost to Tigers (54-36), 12-3 | Kingdome (20-23) | 36-56 | Lost 3 |
| » W: Walt Terrell (4-7) L: Steve Trout (4-5) | Seventh | 19½ out |
| Tuesday, July 19 |
| » Defeated Tigers (54-37), 9-6 | Kingdome (21-23) | 37-56 | |
| » W: Mike Jackson (5-2) L: Jack Morris (7-11) S: Mike Schooler (6) | Seventh | 20 out |
| Wednesday, July 20 |
| » Lost to Tigers (55-37), 12-5 | Kingdome (21-24) | 37-57 | |
| » W: Doyle Alexander (9-5) L: Mike Moore (4-10) | Seventh | 20 out |
| Thursday, July 21 |
| » Defeated Blue Jays (47-49), 6-2 | Kingdome (22-24) | 38-57 | |
| » W: Scott Bankhead (5-4) L: Dave Stieb (10-7) S: Mike Schooler (7) | Seventh | 19½ out |
| Friday, July 22 |
| » Defeated Blue Jays (47-50), 10-9 | Kingdome (23-24) | 39-57 | Won 2 |
| » W: Mike Schooler (2-3) L: Tom Henke (1-2) | Seventh | 19½ out |
| Saturday, July 23 |
| » Lost to Blue Jays (48-50), 5-2 | Kingdome (23-25) | 39-58 | |
| » W: Jeff Musselman (2-0) L: Steve Trout (4-6) | Seventh | 20½ out |
| Sunday, July 24 |
| » Lost to Blue Jays (49-50), 6-0 | Kingdome (23-26) | 39-59 | Lost 2 |
| » W: Mike Flanagan (10-6) L: Mark Langston (7-9) | Seventh | 21½ out |
| Monday, July 25 |
| » Lost to White Sox (44-54), 6-5 | Comiskey Park I (2-2) | 39-60 | Lost 3 |
| » W: Jerry Reuss (7-7) L: Mike Moore (4-11) S: Bobby Thigpen (21) | Seventh | 21½ out |
| Tuesday, July 26 |
| » Lost to White Sox (45-54), 1-0 | Comiskey Park I (2-3) | 39-61 | Lost 4 |
| » W: Ricky Horton (5-7) L: Mike Schooler (2-4) | Seventh | 22½ out |
| Wednesday, July 27 |
| » Lost to White Sox (46-54), 6-1 | Comiskey Park I (2-4) | 39-62 | Lost 5 |
| » W: Melido Perez (10-5) L: Bill Swift (6-8) | Sixth | 22½ out |
| Friday, July 29 |
| » Defeated Athletics (62-41), 5-3 | Kingdome (24-26) | 40-62 | |
| » W: Mike Jackson (6-2) L: Dennis Eckersley (2-2) | Seventh | 21½ out |
| Saturday, July 30 |
| » Lost to Athletics (63-41), 5-2 | Kingdome (24-27) | 40-63 | |
| » W: Dave Stewart (13-10) L: Mike Moore (4-12) | Seventh | 22½ out |
| Sunday, July 31 |
| » Lost to Athletics (64-41), 6-2 | Kingdome (24-28) | 40-64 | Lost 2 |
| » W: Storm Davis (10-4) L: Scott Bankhead (5-5) S: Greg Cadaret (1) | Seventh | 23½ out |
| Monday, August 1 |
| » Lost to Angels (54-51), 8-4 | Kingdome (24-29) | 40-65 | Lost 3 |
| » W: Terry Clark (4-0) L: Bill Swift (6-9) | Seventh | 24½ out |
| Tuesday, August 2 |
| » Lost to Angels (55-51), 10-2 | Kingdome (24-30) | 40-66 | Lost 4 |
| » W: Chuck Finley (6-9) L: Steve Trout (4-7) | Seventh | 24½ out |
| Wednesday, August 3 |
| » Defeated Angels (55-52), 8-7 | Kingdome (25-30) | 41-66 | |
| » W: Mike Schooler (3-4) L: Bryan Harvey (4-4) | Seventh | 24½ out |
| Thursday, August 4 |
| » Lost to Athletics (67-42), 2-0 | Oakland-Alameda County Stadium (1-3) | 41-67 | |
| » W: Dave Stewart (14-10) L: Mike Moore (4-13) | Seventh | 25½ out |
| Friday, August 5 |
| » Lost to Athletics (68-42), 4-1 | Oakland-Alameda County Stadium (1-4) | 41-68 | Lost 2 |
| » W: Storm Davis (11-4) L: Scott Bankhead (5-6) S: Dennis Eckersley (32) | Seventh | 26½ out |
| Saturday, August 6 |
| » Lost to Athletics (69-42), 5-4 | Oakland-Alameda County Stadium (1-5) | 41-69 | Lost 3 |
| » W: Gene Nelson (7-3) L: Mike Jackson (6-3) | Seventh | 27½ out |
| Sunday, August 7 |
| » Defeated Athletics (69-43), 12-7 | Oakland-Alameda County Stadium (2-5) | 42-69 | |
| » W: Mike Schooler (4-4) L: Eric Plunk (5-2) | Seventh | 26½ out |
| Monday, August 8 |
| » Defeated Angels (57-55), 4-3 | Anaheim Stadium (4-1) | 43-69 | Won 2 |
| » W: Mark Langston (8-9) L: Kirk McCaskill (8-6) S: Mike Schooler (8) | Seventh | 26½ out |
| Tuesday, August 9 |
| » Defeated Angels (57-56), 4-1 | Anaheim Stadium (5-1) | 44-69 | Won 3 |
| » W: Mike Moore (5-13) L: Mike Witt (8-11) S: Mike Jackson (3) | Seventh | 26½ out |
| Wednesday, August 10 |
| » Lost to Angels (58-56), 2-1 | Anaheim Stadium (5-2) | 44-70 | |
| » W: Willie Fraser (8-10) L: Scott Bankhead (5-7) | Seventh | 27½ out |
| Thursday, August 11 |
| » Lost to White Sox (50-65), 4-3 | Kingdome (25-31) | 44-71 | Lost 2 |
| » W: Jerry Reuss (8-7) L: Mike Jackson (6-4) S: Bobby Thigpen (25) | Seventh | 28½ out |
| Friday, August 12 |
| » Lost to White Sox (51-65), 7-2 | Kingdome (25-32) | 44-72 | Lost 3 |
| » W: Dave LaPoint (10-11) L: Dennis Powell (1-3) | Seventh | 29½ out |
| Saturday, August 13 |
| » Lost to White Sox (52-65), 7-4 | Kingdome (25-33) | 44-73 | Lost 4 |
| » W: Melido Perez (11-7) L: Mark Langston (8-10) S: Ricky Horton (2) | Seventh | 30½ out |
| Sunday, August 14 |
| » Defeated White Sox (52-66), 11-0 | Kingdome (26-33) | 45-73 | |
| » W: Mike Moore (6-13) L: Bill Long (4-8) | Seventh | 29½ out |
| Tuesday, August 16 |
| » Defeated Red Sox (66-52), 7-0 | Fenway Park (2-2) | 46-73 | Won 2 |
| » W: Scott Bankhead (6-7) L: Wes Gardner (5-4) | Seventh | 29½ out |
| Wednesday, August 17 |
| » Lost to Red Sox (67-52), 7-2 | Fenway Park (2-3) | 46-74 | |
| » W: Bruce Hurst (14-4) L: Bill Swift (6-10) | Seventh | 30½ out |
| Thursday, August 18 |
| » Defeated Red Sox (67-53), 6-1 | Fenway Park (3-3) | 47-74 | |
| » W: Mark Langston (9-10) L: Mike Boddicker (9-14) | Seventh | 29½ out |
| Friday, August 19 |
| » Lost to Yankees (66-52), 5-3 | Yankee Stadium (1-2) | 47-75 | |
| » W: Dave Righetti (4-3) L: Mike Schooler (4-5) | Seventh | 29 out |
| » Defeated Yankees (66-53), 6-1 | Yankee Stadium (2-2) | 48-75 | |
| » W: Mike Moore (7-13) L: Richard Dotson (9-6) | Seventh | 29 out |
| Saturday, August 20 |
| » Defeated Yankees (66-54), 9-5 | Yankee Stadium (3-2) | 49-75 | Won 2 |
| » W: Mike Campbell (4-8) L: Scott Nielsen (1-1) | Seventh | 28 out |
| Sunday, August 21 |
| » Defeated Yankees (66-55), 4-2 | Yankee Stadium (4-2) | 50-75 | Won 3 |
| » W: Scott Bankhead (7-7) L: Rick Rhoden (7-10) S: Mike Schooler (9) | Seventh | 28 out |
| Monday, August 22 |
| » Defeated Orioles (42-82), 7-3 | Memorial Stadium (2-2) | 51-75 | Won 4 |
| » W: Bill Wilkinson (1-2) L: Oswaldo Peraza (5-6) | Seventh | 28 out |
| Wednesday, August 24 |
| » Lost to Orioles (43-82), 4-3 | Memorial Stadium (2-3) | 51-76 | |
| » W: Mark Williamson (3-5) L: Mike Schooler (4-6) | Seventh | 28 out |
| » Lost to Orioles (44-82), 4-3 | Memorial Stadium (2-4) | 51-77 | Lost 2 |
| » W: Tom Niedenfuer (2-3) L: Rod Scurry (0-2) | Seventh | 28 out |
| Friday, August 26 |
| » Lost to Red Sox (72-55), 5-3 | Kingdome (26-34) | 51-78 | Lost 3 |
| » W: Oil Can Boyd (9-7) L: Scott Bankhead (7-8) S: Lee Smith (20) | Seventh | 29 out |
| Saturday, August 27 |
| » Defeated Red Sox (72-56), 8-6 | Kingdome (27-34) | 52-78 | |
| » W: Bill Wilkinson (2-2) L: Tom Bolton (1-3) S: Mike Schooler (10) | Seventh | 29 out |
| Sunday, August 28 |
| » Lost to Red Sox (73-56), 7-2 | Kingdome (27-35) | 52-79 | |
| » W: Bruce Hurst (16-4) L: Mike Moore (7-14) | Seventh | 29 out |
| Monday, August 29 |
| » Defeated Yankees (68-61), 9-6 | Kingdome (28-35) | 53-79 | |
| » W: Mark Langston (10-10) L: Scott Nielsen (1-2) | Seventh | 29 out |
| Tuesday, August 30 |
| » Defeated Yankees (68-62), 7-1 | Kingdome (29-35) | 54-79 | Won 2 |
| » W: Mike Campbell (5-8) L: Richard Dotson (9-8) | Seventh | 29 out |
| Wednesday, August 31 |
| » Lost to Yankees (69-62), 4-1 | Kingdome (29-36) | 54-80 | |
| » W: Rick Rhoden (8-10) L: Scott Bankhead (7-9) | Seventh | 30 out |
| Friday, September 2 |
| » Lost to Orioles (47-86), 4-3 | Kingdome (29-37) | 54-81 | Lost 2 |
| » W: Gregg Olson (1-0) L: Mike Schooler (4-7) S: Tom Niedenfuer (16) | Seventh | 30 out |
| » Major-league debuts: Gregg Olson (Orioles) |
| Saturday, September 3 |
| » Defeated Orioles (47-87), 1-0 | Kingdome (30-37) | 55-81 | |
| » W: Mark Langston (11-10) L: Jose Bautista (6-12) | Seventh | 30 out |
| Sunday, September 4 |
| » Lost to Orioles (48-87), 6-4 | Kingdome (30-38) | 55-82 | |
| » W: Mark Williamson (5-6) L: Terry Taylor (0-1) S: Tom Niedenfuer (17) | Seventh | 31 out |
| Monday, September 5 |
| » Lost to Twins (77-60), 2-0 | Hubert H. Humphrey Metrodome (0-4) | 55-83 | Lost 2 |
| » W: Frank Viola (21-6) L: Erik Hanson (0-1) S: Jeff Reardon (36) | Seventh | 32 out |
| » Major-league debuts: Erik Hanson (Mariners) |
| Tuesday, September 6 |
| » Defeated Twins (77-61), 8-3 | Hubert H. Humphrey Metrodome (1-4) | 56-83 | |
| » W: Mike Campbell (6-8) L: Bert Blyleven (9-14) S: Mike Schooler (11) | Seventh | 31 out |
| Wednesday, September 7 |
| » Defeated Twins (77-62), 2-1 | Hubert H. Humphrey Metrodome (2-4) | 57-83 | Won 2 |
| » W: Bill Swift (7-10) L: Dan Schatzeder (0-3) | Seventh | 31 out |
| Thursday, September 8 |
| » Major-league debuts: Tom Gordon Mark Lee and Rey Palacios (Royals) |
| Friday, September 9 |
| » Lost to Brewers (75-68), 2-1 | County Stadium (0-4) | 57-84 | |
| » W: Chris Bosio (7-14) L: Mark Langston (11-11) | Seventh | 32½ out |
| Saturday, September 10 |
| » Defeated Brewers (75-69), 1-0 | County Stadium (1-4) | 58-84 | |
| » W: Erik Hanson (1-1) L: Teddy Higuera (13-9) S: Mike Schooler (12) | Seventh | 31½ out |
| Sunday, September 11 |
| » Lost to Brewers (76-69), 5-3 | County Stadium (1-5) | 58-85 | |
| » W: Don August (10-6) L: Mike Campbell (6-9) S: Dan Plesac (30) | Seventh | 32½ out |
| Monday, September 12 |
| » Defeated Twins (79-64), 3-1 | Kingdome (31-38) | 59-85 | |
| » W: Mike Moore (8-14) L: Allan Anderson (13-9) | Seventh | 32 out |
| Tuesday, September 13 |
| » Lost to Twins (80-64), 2-1 | Kingdome (31-39) | 59-86 | |
| » W: Keith Atherton (7-5) L: Bill Swift (7-11) S: Jeff Reardon (38) | Seventh | 33 out |
| Wednesday, September 14 |
| » Defeated Twins (80-65), 2-0 | Kingdome (32-39) | 60-86 | |
| » W: Mark Langston (12-11) L: Freddie Toliver (7-4) S: Mike Schooler (13) | Seventh | 32 out |
| Friday, September 16 |
| » Lost to Brewers (79-70), 5-1 | Kingdome (32-40) | 60-87 | |
| » W: Don August (11-6) L: Erik Hanson (1-2) | Seventh | 32½ out |
| Saturday, September 17 |
| » Defeated Brewers (79-71), 11-0 | Kingdome (33-40) | 61-87 | |
| » W: Mike Moore (9-14) L: Mike Birkbeck (10-8) | Seventh | 32½ out |
| Sunday, September 18 |
| » Lost to Brewers (80-71), 10-2 | Kingdome (33-41) | 61-88 | |
| » W: Juan Nieves (7-5) L: Mike Campbell (6-10) | Seventh | 33½ out |
| Monday, September 19 |
| » Defeated Royals (79-71), 4-0 | Kingdome (34-41) | 62-88 | |
| » W: Mark Langston (13-11) L: Floyd Bannister (11-13) | Seventh | 33½ out |
| Tuesday, September 20 |
| » Defeated Royals (79-72), 11-10 | Kingdome (35-41) | 63-88 | Won 2 |
| » W: Mike Schooler (5-7) L: Jerry Don Gleaton (0-4) | Seventh | 33½ out |
| Wednesday, September 21 |
| » Lost to Royals (80-72), 5-4 | Kingdome (35-42) | 63-89 | |
| » W: Mark Gubicza (19-7) L: Mike Jackson (6-5) S: Israel Sanchez (1) | Seventh | 34½ out |
| Friday, September 23 |
| » Lost to Rangers (67-85), 3-2 | Arlington Stadium (1-3) | 63-90 | Lost 2 |
| » W: Charlie Hough (15-15) L: Mike Schooler (5-8) | Seventh | 35½ out |
| Saturday, September 24 |
| » Defeated Rangers (67-86), 3-0 | Arlington Stadium (2-3) | 64-90 | |
| » W: Mark Langston (14-11) L: Jeff Russell (10-8) | Seventh | 35½ out |
| Sunday, September 25 |
| » Defeated Rangers (67-87), 8-5 | Arlington Stadium (3-3) | 65-90 | Won 2 |
| » W: Gene Walter (1-1) L: Craig McMurtry (2-3) S: Mike Schooler (14) | Sixth | 34½ out |
| Monday, September 26 |
| » Lost to Royals (82-74), 5-0 | Royals Stadium (0-5) | 65-91 | |
| » W: Mark Gubicza (20-7) L: Bill Swift (7-12) | Seventh | 35 out |
| Tuesday, September 27 |
| » Defeated Royals (82-75), 10-3 | Royals Stadium (1-5) | 66-91 | |
| » W: Erik Hanson (2-2) L: Tom Gordon (0-2) S: Mike Jackson (4) | Sixth | 34 out |
| Thursday, September 29 |
| » Defeated Rangers (68-90), 5-1 | Kingdome (36-42) | 67-91 | Won 2 |
| » W: Mark Langston (15-11) L: Jeff Russell (10-9) S: Mike Schooler (15) | Seventh | 34½ out |
| Friday, September 30 |
| » Lost to Rangers (69-90), 11-6 | Kingdome (36-43) | 67-92 | |
| » W: Craig McMurtry (3-3) L: Mike Moore (9-15) | Sixth | 35½ out |
| Saturday, October 1 |
| » Defeated Rangers (69-91), 4-3 | Kingdome (37-43) | 68-92 | |
| » W: Bill Swift (8-12) L: Dwayne Henry (0-1) | Seventh | 34½ out |
| Sunday, October 2 |
| » Lost to Rangers (70-91), 7-2 | Kingdome (37-44) | 68-93 | |
| » W: Paul Kilgus (12-15) L: Erik Hanson (2-3) S: Craig McMurtry (3) | Seventh | 35½ out |
Game information provided by Retrosheet (www.retrosheet.org) |