| Tuesday, February 23 |
| Former Indian Pete Donohue dies in Ft.Worth, TX at the age of 88. |
| Sunday, February 28 |
| Former Indian Harvey Kuenn dies in Peoria, AZ at the age of 58. |
| Monday, April 4 |
| » Lost to Rangers (1-0), 4-3 | Arlington Stadium (0-1) | 0-1 | |
| » W: Charlie Hough (1-0) L: Chris Codiroli (0-1) S: Mitch Williams (1) | Third | 1 out |
| Wednesday, April 6 |
| » Defeated Rangers (1-1), 5-1 | Arlington Stadium (1-1) | 1-1 | |
| » W: Greg Swindell (1-0) L: Bobby Witt (0-1) | Second | 1 out |
| Thursday, April 7 |
| » Defeated Rangers (1-2), 4-1 | Arlington Stadium (2-1) | 2-1 | Won 2 |
| » W: John Farrell (1-0) L: Jose Guzman (0-1) S: Chris Codiroli (1) | Second | ½ out |
| Friday, April 8 |
| » Defeated Orioles (0-3), 3-0 | Cleveland Stadium (1-0) | 3-1 | Won 3 |
| » W: Scott Bailes (1-0) L: Mark Thurmond (0-1) | Second | ½ out |
| Saturday, April 9 |
| » Defeated Orioles (0-4), 12-1 | Cleveland Stadium (2-0) | 4-1 | Won 4 |
| » W: Tom Candiotti (1-0) L: Mike Boddicker (0-2) | Second | ½ out |
| » Major-league debuts: Jose Bautista (Orioles) |
| Sunday, April 10 |
| » Defeated Orioles (0-5), 6-3 | Cleveland Stadium (3-0) | 5-1 | Won 5 |
| » W: Rich Yett (1-0) L: Scott McGregor (0-1) S: Dan Schatzeder (1) | Second | ½ out |
| Monday, April 11 |
| » Defeated Orioles (0-6), 7-2 | Cleveland Stadium (4-0) | 6-1 | Won 6 |
| » W: Greg Swindell (2-0) L: Mike Morgan (0-2) | First | -- |
| Tuesday, April 12 |
| » Lost to Twins (3-3), 7-6 | Cleveland Stadium (4-1) | 6-2 | |
| » W: Joe Niekro (1-0) L: Chris Codiroli (0-2) S: Jeff Reardon (3) | Second | ½ out |
| Wednesday, April 13 |
| » Defeated Twins (3-4), 6-3 | Cleveland Stadium (5-1) | 7-2 | |
| » W: Jeff Dedmon (1-0) L: Juan Berenguer (0-2) | Second | ½ out |
| Thursday, April 14 |
| » Defeated Twins (3-5), 3-1 | Cleveland Stadium (6-1) | 8-2 | Won 2 |
| » W: Tom Candiotti (2-0) L: Charlie Lea (0-2) | Second | ½ out |
| Former Indian Ralph Winegarner dies in Wichita, KS at the age of 79. |
| Friday, April 15 |
| » Defeated Orioles (0-10), 3-2 | Memorial Stadium (1-0) | 9-2 | Won 3 |
| » W: Rich Yett (2-0) L: Scott McGregor (0-2) S: Doug Jones (1) | Second | ½ out |
| Saturday, April 16 |
| » Defeated Orioles (0-11), 1-0 | Memorial Stadium (2-0) | 10-2 | Won 4 |
| » W: Greg Swindell (3-0) L: Dave Schmidt (0-1) S: Doug Jones (2) | First | -- |
| Sunday, April 17 |
| » Defeated Orioles (0-12), 4-1 | Memorial Stadium (3-0) | 11-2 | Won 5 |
| » W: John Farrell (2-0) L: Oswaldo Peraza (0-2) S: Dan Schatzeder (2) | First | -- |
| Tuesday, April 19 |
| » Lost to Rangers (6-7), 3-0 | Cleveland Stadium (6-2) | 11-3 | |
| » W: Jose Guzman (2-1) L: Scott Bailes (1-1) S: Mitch Williams (5) | First | -- |
| Wednesday, April 20 |
| » Defeated Rangers (6-8), 2-1 | Cleveland Stadium (7-2) | 12-3 | |
| » W: Tom Candiotti (3-0) L: Charlie Hough (2-2) | First | -- |
| Friday, April 22 |
| » Defeated Twins (4-10), 11-6 | Hubert H. Humphrey Metrodome (1-0) | 13-3 | Won 2 |
| » W: Greg Swindell (4-0) L: Bert Blyleven (1-2) S: Doug Jones (3) | First | -- |
| Saturday, April 23 |
| » Defeated Twins (4-11), 10-2 | Hubert H. Humphrey Metrodome (2-0) | 14-3 | Won 3 |
| » W: John Farrell (3-0) L: Steve Carlton (0-1) | First | -- |
| Sunday, April 24 |
| » Lost to Twins (5-11), 13-7 | Hubert H. Humphrey Metrodome (2-1) | 14-4 | |
| » W: Juan Berenguer (2-2) L: Scott Bailes (1-2) | First | -- |
| Tuesday, April 26 |
| » Defeated Mariners (9-11), 12-6 | Cleveland Stadium (8-2) | 15-4 | |
| » W: Tom Candiotti (4-0) L: Mike Moore (2-2) | First | -- |
| Wednesday, April 27 |
| » Defeated Mariners (9-12), 6-4 | Cleveland Stadium (9-2) | 16-4 | Won 2 |
| » W: Greg Swindell (5-0) L: Steve Trout (2-2) S: Doug Jones (4) | First | -- |
| Thursday, April 28 |
| » Lost to Mariners (10-12), 3-1 | Cleveland Stadium (9-3) | 16-5 | |
| » W: Mike Campbell (2-2) L: John Farrell (3-1) | First | -- |
| Saturday, April 30 |
| » Lost to Athletics (16-7), 11-3 | Cleveland Stadium (9-4) | 16-6 | Lost 2 |
| » W: Bob Welch (3-2) L: Rich Yett (2-1) S: Gene Nelson (1) | First | -- |
| Sunday, May 1 |
| » Lost to Athletics (17-7), 8-4 | Cleveland Stadium (9-5) | 16-7 | Lost 3 |
| » W: Eric Plunk (2-1) L: Doug Jones (0-1) | First | -- |
| Monday, May 2 |
| » Defeated Angels (10-15), 3-0 | Cleveland Stadium (10-5) | 17-7 | |
| » W: Greg Swindell (6-0) L: Willie Fraser (3-1) | First | -- |
| Tuesday, May 3 |
| » Lost to Angels (11-15), 8-4 | Cleveland Stadium (10-6) | 17-8 | |
| » W: Donnie Moore (2-2) L: Dan Schatzeder (0-1) | Second | ½ out |
| Wednesday, May 4 |
| » Lost to Mariners (12-16), 5-4 | Kingdome (0-1) | 17-9 | Lost 2 |
| » W: Mark Langston (2-3) L: Scott Bailes (1-3) S: Julio Solano (3) | Second | 1½ out |
| Thursday, May 5 |
| » Lost to Mariners (13-16), 7-2 | Kingdome (0-2) | 17-10 | Lost 3 |
| » W: Bill Swift (2-0) L: Rich Yett (2-2) | Second | 2½ out |
| Saturday, May 7 |
| » Lost to Athletics (22-7), 14-3 | Oakland-Alameda County Stadium (0-1) | 17-11 | Lost 4 |
| » W: Storm Davis (3-1) L: Tom Candiotti (4-1) S: Gene Nelson (2) | Second | 2 out |
| Sunday, May 8 |
| » Lost to Athletics (23-7), 5-1 | Oakland-Alameda County Stadium (0-2) | 17-12 | Lost 5 |
| » W: Dave Stewart (8-0) L: Greg Swindell (6-1) | Fourth | 2 out |
| Monday, May 9 |
| » Lost to Angels (13-19), 2-1 | Anaheim Stadium (0-1) | 17-13 | Lost 6 |
| » W: Dan Petry (2-2) L: John Farrell (3-2) S: Bryan Harvey (1) | Fifth | 2½ out |
| Tuesday, May 10 |
| » Defeated Angels (13-20), 7-1 | Anaheim Stadium (1-1) | 18-13 | |
| » W: Scott Bailes (2-3) L: Chuck Finley (2-5) | Fourth | 2½ out |
| Wednesday, May 11 |
| » Defeated Angels (13-21), 4-3 | Anaheim Stadium (2-1) | 19-13 | Won 2 |
| » W: Doug Jones (1-1) L: Bryan Harvey (1-1) | Third | 2½ out |
| Thursday, May 12 |
| » Defeated Brewers (18-14), 3-1 | County Stadium (1-0) | 20-13 | Won 3 |
| » W: Tom Candiotti (5-1) L: Chuck Crim (0-2) | Third | 2 out |
| Friday, May 13 |
| » Defeated Brewers (18-15), 4-3 | County Stadium (2-0) | 21-13 | Won 4 |
| » W: Greg Swindell (7-1) L: Teddy Higuera (3-2) S: Doug Jones (5) | Third | 1 out |
| Saturday, May 14 |
| » Defeated Brewers (18-16), 6-4 | County Stadium (3-0) | 22-13 | Won 5 |
| » W: John Farrell (4-2) L: Mike Birkbeck (1-3) S: Bill Laskey (1) | Second | 1 out |
| Sunday, May 15 |
| » Lost to Brewers (19-16), 9-5 | County Stadium (3-1) | 22-14 | |
| » W: Bill Wegman (4-4) L: Scott Bailes (2-4) S: Paul Mirabella (1) | Second | 2 out |
| Tuesday, May 17 |
| » Defeated White Sox (18-18), 6-2 | Cleveland Stadium (11-6) | 23-14 | |
| » W: Rich Yett (3-2) L: Jack McDowell (2-4) S: Doug Jones (6) | Second | 1½ out |
| Wednesday, May 18 |
| » Defeated White Sox (18-19), 2-1 | Cleveland Stadium (12-6) | 24-14 | Won 2 |
| » W: Tom Candiotti (6-1) L: Melido Perez (3-1) | Second | 1 out |
| Thursday, May 19 |
| » Defeated White Sox (18-20), 1-0 | Cleveland Stadium (13-6) | 25-14 | Won 3 |
| » W: Greg Swindell (8-1) L: Bobby Thigpen (1-4) | Second | ½ out |
| Friday, May 20 |
| » Lost to Royals (20-20), 4-3 | Royals Stadium (0-1) | 25-15 | |
| » W: Mark Gubicza (5-4) L: John Farrell (4-3) S: Steve Farr (2) | Second | ½ out |
| Saturday, May 21 |
| » Defeated Royals (20-21), 9-5 | Royals Stadium (1-1) | 26-15 | |
| » W: Scott Bailes (3-4) L: Floyd Bannister (6-3) S: Doug Jones (7) | Second | ½ out |
| Sunday, May 22 |
| » Defeated Royals (20-22), 8-7 | Royals Stadium (2-1) | 27-15 | Won 2 |
| » W: Bill Laskey (1-0) L: Gene Garber (0-2) S: Doug Jones (8) | Second | ½ out |
| Monday, May 23 |
| » Lost to White Sox (19-23), 3-2 | Comiskey Park I (0-1) | 27-16 | |
| » W: Melido Perez (4-1) L: Tom Candiotti (6-2) S: Bobby Thigpen (7) | Third | 1½ out |
| Tuesday, May 24 |
| » Defeated White Sox (19-24), 4-3 | Comiskey Park I (1-1) | 28-16 | |
| » W: Greg Swindell (9-1) L: Dave LaPoint (4-3) S: Doug Jones (9) | Second | 1½ out |
| Wednesday, May 25 |
| » Defeated White Sox (19-25), 5-2 | Comiskey Park I (2-1) | 29-16 | Won 2 |
| » W: John Farrell (5-3) L: John Davis (1-2) | Second | 1½ out |
| Friday, May 27 |
| » Defeated Brewers (23-23), 6-3 | Cleveland Stadium (14-6) | 30-16 | Won 3 |
| » W: Scott Bailes (4-4) L: Mike Birkbeck (2-4) S: Doug Jones (10) | Second | 1½ out |
| Saturday, May 28 |
| » Lost to Brewers (24-23), 2-0 | Cleveland Stadium (14-7) | 30-17 | |
| » W: Odell Jones (3-0) L: Rich Yett (3-3) S: Dan Plesac (10) | Second | 1½ out |
| Sunday, May 29 |
| » Lost to Brewers (25-23), 7-2 | Cleveland Stadium (14-8) | 30-18 | Lost 2 |
| » W: Tom Filer (2-0) L: Tom Candiotti (6-3) | Second | 2½ out |
| Monday, May 30 |
| » Defeated Royals (22-27), 4-1 | Cleveland Stadium (15-8) | 31-18 | |
| » W: Greg Swindell (10-1) L: Charlie Leibrandt (2-8) S: Doug Jones (11) | Second | 1½ out |
| Tuesday, May 31 |
| » Lost to Royals (23-27), 6-3 | Cleveland Stadium (15-9) | 31-19 | |
| » W: Mark Gubicza (6-5) L: Dan Schatzeder (0-2) S: Steve Farr (3) | Second | 2½ out |
| Wednesday, June 1 |
| » Defeated Royals (23-28), 5-4 | Cleveland Stadium (16-9) | 32-19 | |
| » W: Scott Bailes (5-4) L: Floyd Bannister (6-5) S: Doug Jones (12) | Second | 1½ out |
| Former Indian Belve Bean dies in Comanche, TX at the age of 84. |
| Friday, June 3 |
| » Defeated Tigers (29-21), 6-3 | Tiger Stadium (1-0) | 33-19 | Won 2 |
| » W: Rich Yett (4-3) L: Walt Terrell (2-3) S: Dan Schatzeder (3) | Second | 1½ out |
| Saturday, June 4 |
| » Lost to Tigers (30-21), 5-2 | Tiger Stadium (1-1) | 33-20 | |
| » W: Doyle Alexander (5-4) L: Tom Candiotti (6-4) | Second | 1½ out |
| Sunday, June 5 |
| » Lost to Tigers (31-21), 6-2 | Tiger Stadium (1-2) | 33-21 | Lost 2 |
| » W: Jeff Robinson (6-2) L: Greg Swindell (10-2) | Second | 2½ out |
| Monday, June 6 |
| » Defeated Blue Jays (27-30), 6-3 | Cleveland Stadium (17-9) | 34-21 | |
| » W: John Farrell (6-3) L: Mike Flanagan (5-4) S: Doug Jones (13) | Second | 1½ out |
| Tuesday, June 7 |
| » Defeated Blue Jays (27-31), 5-3 | Cleveland Stadium (18-9) | 35-21 | Won 2 |
| » W: Scott Bailes (6-4) L: David Wells (3-3) | Second | 1½ out |
| Wednesday, June 8 |
| » Defeated Blue Jays (27-32), 4-2 | Cleveland Stadium (19-9) | 36-21 | Won 3 |
| » W: Rich Yett (5-3) L: Jim Clancy (3-7) S: Doug Jones (14) | Second | ½ out |
| Thursday, June 9 |
| » Lost to Tigers (33-23), 6-2 | Cleveland Stadium (19-10) | 36-22 | |
| » W: Mike Henneman (1-1) L: Tom Candiotti (6-5) | Second | 1 out |
| Friday, June 10 |
| » Lost to Tigers (34-23), 2-1 | Cleveland Stadium (19-11) | 36-23 | Lost 2 |
| » W: Jeff Robinson (7-2) L: Greg Swindell (10-3) S: Mike Henneman (12) | Second | 1 out |
| Saturday, June 11 |
| » Lost to Tigers (35-23), 11-3 | Cleveland Stadium (19-12) | 36-24 | Lost 3 |
| » W: Jack Morris (6-7) L: John Farrell (6-4) | Third | 2 out |
| Sunday, June 12 |
| » Lost to Tigers (36-23), 5-4 | Cleveland Stadium (19-13) | 36-25 | Lost 4 |
| » W: Frank Tanana (9-4) L: Scott Bailes (6-5) S: Mike Henneman (13) | Third | 3 out |
| Monday, June 13 |
| » Defeated Blue Jays (29-34), 8-6 | Exhibition Stadium (1-0) | 37-25 | |
| » W: Bud Black (3-1) L: Jim Clancy (3-8) S: Doug Jones (15) | Third | 3 out |
| Tuesday, June 14 |
| » Lost to Blue Jays (30-34), 3-2 | Exhibition Stadium (1-1) | 37-26 | |
| » W: Duane Ward (4-0) L: Tom Candiotti (6-6) | Third | 3 out |
| Wednesday, June 15 |
| » Lost to Blue Jays (31-34), 15-3 | Exhibition Stadium (1-2) | 37-27 | Lost 2 |
| » W: Dave Stieb (9-3) L: Greg Swindell (10-4) | Third | 3 out |
| Friday, June 17 |
| » Defeated Yankees (39-24), 6-4 | Cleveland Stadium (20-13) | 38-27 | |
| » W: John Farrell (7-4) L: John Candelaria (8-3) S: Doug Jones (16) | Third | 2 out |
| Saturday, June 18 |
| » Lost to Yankees (40-24), 6-3 | Cleveland Stadium (20-14) | 38-28 | |
| » W: Rick Rhoden (3-5) L: Scott Bailes (6-6) S: Cecilio Guante (8) | Third | 3 out |
| Sunday, June 19 |
| » Defeated Yankees (40-25), 11-3 | Cleveland Stadium (21-14) | 39-28 | |
| » W: Tom Candiotti (7-6) L: Richard Dotson (7-2) | Third | 2 out |
| Monday, June 20 |
| » Lost to Red Sox (33-32), 14-7 | Cleveland Stadium (21-15) | 39-29 | |
| » W: Bruce Hurst (9-3) L: Greg Swindell (10-5) | Third | 2½ out |
| Tuesday, June 21 |
| » Lost to Red Sox (34-32), 10-6 | Cleveland Stadium (21-16) | 39-30 | Lost 2 |
| » W: Bob Stanley (2-0) L: Rick Rodriguez (0-1) S: Lee Smith (10) | Third | 3½ out |
| Wednesday, June 22 |
| » Defeated Red Sox (34-33), 3-1 | Cleveland Stadium (22-16) | 40-30 | |
| » W: John Farrell (8-4) L: Oil Can Boyd (6-6) S: Doug Jones (17) | Third | 3½ out |
| Former Indian Hank Edwards dies in Santa Ana, CA at the age of 70. |
| Thursday, June 23 |
| » Lost to Yankees (41-28), 4-3 | Yankee Stadium (0-1) | 40-31 | |
| » W: Dave Righetti (2-0) L: Jon Perlman (0-1) | Third | 4 out |
| Friday, June 24 |
| » Defeated Yankees (41-29), 7-5 | Yankee Stadium (1-1) | 41-31 | |
| » W: Brad Havens (1-0) L: Richard Dotson (7-3) S: Doug Jones (18) | Third | 3 out |
| Saturday, June 25 |
| » Lost to Yankees (42-29), 4-1 | Yankee Stadium (1-2) | 41-32 | |
| » W: Tommy John (5-2) L: Greg Swindell (10-6) S: Cecilio Guante (9) | Third | 4 out |
| Sunday, June 26 |
| » Lost to Yankees (43-29), 4-3 | Yankee Stadium (1-3) | 41-33 | Lost 2 |
| » W: Dave Righetti (3-0) L: Bud Black (3-2) | Third | 4 out |
| Monday, June 27 |
| » Lost to Red Sox (37-34), 9-5 | Fenway Park (0-1) | 41-34 | Lost 3 |
| » W: Dennis Lamp (2-3) L: John Farrell (8-5) | Third | 5 out |
| Tuesday, June 28 |
| » Lost to Red Sox (38-34), 6-1 | Fenway Park (0-2) | 41-35 | Lost 4 |
| » W: Wes Gardner (2-1) L: Scott Bailes (6-7) | Third | 6 out |
| Wednesday, June 29 |
| » Lost to Red Sox (39-34), 5-1 | Fenway Park (0-3) | 41-36 | Lost 5 |
| » W: Roger Clemens (11-5) L: Tom Candiotti (7-7) S: Lee Smith (11) | Fourth | 6 out |
| Friday, July 1 |
| » Lost to Mariners (31-48), 11-3 | Cleveland Stadium (22-17) | 41-37 | Lost 6 |
| » W: Mark Langston (6-8) L: Greg Swindell (10-7) S: Mike Jackson (2) | Fourth | 7 out |
| Saturday, July 2 |
| » Defeated Mariners (31-49), 10-7 | Cleveland Stadium (23-17) | 42-37 | |
| » W: John Farrell (9-5) L: Bill Swift (6-5) S: Doug Jones (19) | Third | 7 out |
| Sunday, July 3 |
| » Lost to Mariners (32-49), 7-6 | Cleveland Stadium (23-18) | 42-38 | |
| » W: Scott Bankhead (3-3) L: Jon Perlman (0-2) S: Mike Schooler (3) | Third | 7 out |
| Monday, July 4 |
| » Lost to Athletics (52-29), 4-2 | Cleveland Stadium (23-19) | 42-39 | Lost 2 |
| » W: Greg Cadaret (2-1) L: Brad Havens (1-1) S: Dennis Eckersley (25) | Third | 8 out |
| Tuesday, July 5 |
| » Defeated Athletics (52-30), 3-0 | Cleveland Stadium (24-19) | 43-39 | |
| » W: Scott Bailes (7-7) L: Dave Stewart (11-7) | Third | 6½ out |
| » Defeated Athletics (52-31), 4-2 | Cleveland Stadium (25-19) | 44-39 | Won 2 |
| » W: Rick Rodriguez (1-1) L: Rich Bordi (0-1) S: Doug Jones (20) | Third | 6½ out |
| Wednesday, July 6 |
| » Defeated Athletics (52-32), 8-6 | Cleveland Stadium (26-19) | 45-39 | Won 3 |
| » W: Don Gordon (1-0) L: Rick Honeycutt (2-2) | Third | 6½ out |
| Thursday, July 7 |
| » Lost to Angels (38-46), 7-1 | Cleveland Stadium (26-20) | 45-40 | |
| » W: Terry Clark (1-0) L: John Farrell (9-6) S: Greg Minton (2) | Third | 7½ out |
| » Major-league debuts: Terry Clark (Angels) |
| Friday, July 8 |
| » Lost to Angels (39-46), 10-6 | Cleveland Stadium (26-21) | 45-41 | Lost 2 |
| » W: Kirk McCaskill (6-5) L: Bud Black (3-3) S: Bryan Harvey (9) | Third | 7½ out |
| » Major-league debuts: Doug Davis (Angels) |
| Former Indian Frank Ellerbe dies in Latta, SC at the age of 93. |
| Saturday, July 9 |
| » Lost to Angels (40-46), 8-5 | Cleveland Stadium (26-22) | 45-42 | Lost 3 |
| » W: Bryan Harvey (4-2) L: Doug Jones (1-2) S: Donnie Moore (3) | Third | 8½ out |
| Sunday, July 10 |
| » Lost to Angels (41-46), 7-5 | Cleveland Stadium (26-23) | 45-43 | Lost 4 |
| » W: Willie Fraser (6-8) L: Scott Bailes (7-8) S: Greg Minton (3) | Third | 8½ out |
| Thursday, July 14 |
| » Lost to Mariners (35-53), 3-1 | Kingdome (0-3) | 45-44 | Lost 5 |
| » W: Mark Langston (7-8) L: Greg Swindell (10-8) | Fourth | 8½ out |
| Friday, July 15 |
| » Lost to Mariners (36-53), 8-5 | Kingdome (0-4) | 45-45 | Lost 6 |
| » W: Mike Jackson (4-2) L: Brad Havens (1-2) S: Mike Schooler (5) | Fifth | 8½ out |
| Saturday, July 16 |
| » Defeated Mariners (36-54), 8-2 | Kingdome (1-4) | 46-45 | |
| » W: Bud Black (4-3) L: Scott Bankhead (4-4) S: Doug Jones (21) | Fifth | 8½ out |
| Sunday, July 17 |
| » Defeated Mariners (36-55), 7-4 | Kingdome (2-4) | 47-45 | Won 2 |
| » W: Don Gordon (2-0) L: Bill Swift (6-7) S: Doug Jones (22) | Fifth | 7½ out |
| Monday, July 18 |
| » Lost to Athletics (56-37), 7-2 | Oakland-Alameda County Stadium (0-3) | 47-46 | |
| » W: Todd Burns (2-0) L: Scott Bailes (7-9) | Fifth | 8½ out |
| Tuesday, July 19 |
| » Lost to Athletics (57-37), 4-2 | Oakland-Alameda County Stadium (0-4) | 47-47 | Lost 2 |
| » W: Bob Welch (11-6) L: Greg Swindell (10-9) S: Dennis Eckersley (28) | Sixth | 9 out |
| » Lost to Athletics (58-37), 9-6 | Oakland-Alameda County Stadium (0-5) | 47-48 | Lost 3 |
| » W: Greg Cadaret (3-1) L: Don Gordon (2-1) S: Dennis Eckersley (29) | Sixth | 9 out |
| Wednesday, July 20 |
| » Defeated Athletics (58-38), 5-4 | Oakland-Alameda County Stadium (1-5) | 48-48 | |
| » W: John Farrell (10-6) L: Dave Stewart (12-9) S: Doug Jones (23) | Fifth | 9 out |
| Friday, July 22 |
| » Lost to Angels (46-49), 7-4 | Anaheim Stadium (2-2) | 48-49 | |
| » W: Terry Clark (3-0) L: Tom Candiotti (7-8) | Fifth | 9 out |
| Saturday, July 23 |
| » Lost to Angels (47-49), 5-4 | Anaheim Stadium (2-3) | 48-50 | Lost 2 |
| » W: Stew Cliburn (4-0) L: Don Gordon (2-2) S: Greg Minton (4) | Fifth | 9 out |
| Sunday, July 24 |
| » Defeated Angels (47-50), 9-2 | Anaheim Stadium (3-3) | 49-50 | |
| » W: Greg Swindell (11-9) L: Willie Fraser (6-10) | Fourth | 8 out |
| Tuesday, July 26 |
| » Defeated Orioles (31-67), 7-3 | Cleveland Stadium (27-23) | 50-50 | Won 2 |
| » W: John Farrell (11-6) L: Jay Tibbs (4-8) S: Doug Jones (24) | Fifth | 8½ out |
| Wednesday, July 27 |
| » Defeated Orioles (31-68), 12-2 | Cleveland Stadium (28-23) | 51-50 | Won 3 |
| » W: Tom Candiotti (8-8) L: Jose Bautista (5-8) | Fourth | 8½ out |
| Thursday, July 28 |
| » Lost to Orioles (32-68), 5-2 | Cleveland Stadium (28-24) | 51-51 | |
| » W: Oswaldo Peraza (3-4) L: Scott Bailes (7-10) S: Tom Niedenfuer (12) | Fifth | 9 out |
| Friday, July 29 |
| » Defeated Twins (55-45), 7-0 | Cleveland Stadium (29-24) | 52-51 | |
| » W: Greg Swindell (12-9) L: Bert Blyleven (7-11) | Fourth | 8½ out |
| Saturday, July 30 |
| » Lost to Twins (56-45), 4-2 | Cleveland Stadium (29-25) | 52-52 | |
| » W: Allan Anderson (8-7) L: Rod Nichols (0-1) | Fourth | 9½ out |
| » Major-league debuts: Rod Nichols (Indians) |
| Sunday, July 31 |
| » Lost to Twins (57-45), 12-4 | Cleveland Stadium (29-26) | 52-53 | Lost 2 |
| » W: Freddie Toliver (2-1) L: John Farrell (11-7) S: Mark Portugal (3) | Fourth | 10½ out |
| Tuesday, August 2 |
| » Lost to Orioles (33-71), 5-2 | Memorial Stadium (3-1) | 52-54 | Lost 3 |
| » W: Oswaldo Peraza (4-4) L: Scott Bailes (7-11) | Fifth | 11 out |
| Wednesday, August 3 |
| » Lost to Orioles (34-71), 8-3 | Memorial Stadium (3-2) | 52-55 | Lost 4 |
| » W: Jeff Ballard (5-9) L: Rick Rodriguez (1-2) | Fifth | 11 out |
| Thursday, August 4 |
| » Lost to Orioles (35-71), 5-0 | Memorial Stadium (3-3) | 52-56 | Lost 5 |
| » W: Dave Schmidt (4-3) L: Greg Swindell (12-10) | Sixth | 12 out |
| Friday, August 5 |
| » Lost to Rangers (47-59), 8-4 | Arlington Stadium (2-2) | 52-57 | Lost 6 |
| » W: Paul Kilgus (9-9) L: Rod Nichols (0-2) S: Craig McMurtry (2) | Sixth | 13½ out |
| Saturday, August 6 |
| » Defeated Rangers (47-60), 5-3 | Arlington Stadium (3-2) | 53-57 | |
| » W: John Farrell (12-7) L: Charlie Hough (9-13) S: Doug Jones (25) | Sixth | 13½ out |
| Sunday, August 7 |
| » Lost to Rangers (48-60), 2-0 | Arlington Stadium (3-3) | 53-58 | |
| » W: Jose Guzman (10-8) L: Rich Yett (5-4) | Sixth | 13½ out |
| Monday, August 8 |
| » Lost to Twins (62-49), 7-2 | Hubert H. Humphrey Metrodome (2-2) | 53-59 | Lost 2 |
| » W: Allan Anderson (10-7) L: Chris Codiroli (0-3) S: Jeff Reardon (29) | Sixth | 14½ out |
| Tuesday, August 9 |
| » Lost to Twins (63-49), 4-3 | Hubert H. Humphrey Metrodome (2-3) | 53-60 | Lost 3 |
| » W: Freddie Toliver (4-1) L: Greg Swindell (12-11) S: Jeff Reardon (30) | Sixth | 14½ out |
| Wednesday, August 10 |
| » Lost to Twins (64-49), 10-4 | Hubert H. Humphrey Metrodome (2-4) | 53-61 | Lost 4 |
| » W: Frank Viola (18-4) L: Rod Nichols (0-3) | Sixth | 15½ out |
| Thursday, August 11 |
| » Lost to Rangers (50-62), 5-4 | Cleveland Stadium (29-27) | 53-62 | Lost 5 |
| » W: Mitch Williams (2-4) L: Doug Jones (1-3) S: Dale Mohorcic (5) | Sixth | 16 out |
| Friday, August 12 |
| » Defeated Rangers (50-63), 6-3 | Cleveland Stadium (30-27) | 54-62 | |
| » W: Rich Yett (6-4) L: Jose Guzman (10-9) S: Don Gordon (1) | Sixth | 15 out |
| Saturday, August 13 |
| » Lost to Rangers (51-63), 12-3 | Cleveland Stadium (30-28) | 54-63 | |
| » W: Jeff Russell (9-5) L: Chris Codiroli (0-4) | Fifth | 15 out |
| Sunday, August 14 |
| » Defeated Rangers (51-64), 3-0 | Cleveland Stadium (31-28) | 55-63 | |
| » W: Greg Swindell (13-11) L: Bobby Witt (4-8) S: Doug Jones (26) | Fifth | 15 out |
| Tuesday, August 16 |
| » Defeated Brewers (61-60), 6-5 | Cleveland Stadium (32-28) | 56-63 | Won 2 |
| » W: Scott Bailes (8-11) L: Chuck Crim (5-6) | Sixth | 13½ out |
| Wednesday, August 17 |
| » Defeated Brewers (61-61), 11-7 | Cleveland Stadium (33-28) | 57-63 | Won 3 |
| » W: John Farrell (13-7) L: Mike Birkbeck (8-6) | Sixth | 12½ out |
| Thursday, August 18 |
| » Defeated Brewers (61-62), 4-3 | Cleveland Stadium (34-28) | 58-63 | Won 4 |
| » W: Rich Yett (7-4) L: Bill Wegman (10-10) S: Doug Jones (27) | Sixth | 12½ out |
| Friday, August 19 |
| » Defeated Royals (62-59), 4-2 | Cleveland Stadium (35-28) | 59-63 | Won 5 |
| » W: Tom Candiotti (9-8) L: Bret Saberhagen (12-13) S: Doug Jones (28) | Sixth | 12½ out |
| Saturday, August 20 |
| » Lost to Royals (63-59), 4-2 | Cleveland Stadium (35-29) | 59-64 | |
| » W: Charlie Leibrandt (8-11) L: Greg Swindell (13-12) S: Steve Farr (15) | Sixth | 13½ out |
| Sunday, August 21 |
| » Lost to Royals (64-59), 3-1 | Cleveland Stadium (35-30) | 59-65 | Lost 2 |
| » W: Mark Gubicza (15-7) L: Rod Nichols (0-4) | Sixth | 14½ out |
| Monday, August 22 |
| » Lost to Brewers (64-63), 7-3 | County Stadium (3-2) | 59-66 | Lost 3 |
| » W: Mike Birkbeck (9-6) L: John Farrell (13-8) S: Chuck Crim (7) | Sixth | 14½ out |
| Tuesday, August 23 |
| » Defeated Brewers (64-64), 6-2 | County Stadium (4-2) | 60-66 | |
| » W: Rich Yett (8-4) L: Bill Wegman (10-11) | Sixth | 13½ out |
| Wednesday, August 24 |
| » Defeated Brewers (64-65), 7-2 | County Stadium (5-2) | 61-66 | Won 2 |
| » W: Tom Candiotti (10-8) L: Tom Filer (5-7) S: Doug Jones (29) | Sixth | 12½ out |
| Friday, August 26 |
| » Defeated White Sox (55-73), 7-6 | Comiskey Park I (3-1) | 62-66 | Won 3 |
| » W: Greg Swindell (14-12) L: Jack McDowell (5-10) S: Doug Jones (30) | Sixth | 12½ out |
| Saturday, August 27 |
| » Lost to White Sox (56-73), 4-1 | Comiskey Park I (3-2) | 62-67 | |
| » W: Jerry Reuss (10-8) L: John Farrell (13-9) | Sixth | 12½ out |
| Sunday, August 28 |
| » Defeated White Sox (56-74), 5-4 | Comiskey Park I (4-2) | 63-67 | |
| » W: Doug Jones (2-3) L: Barry Jones (1-2) | Sixth | 11½ out |
| Monday, August 29 |
| » Lost to Royals (69-61), 6-3 | Royals Stadium (2-2) | 63-68 | |
| » W: Bret Saberhagen (13-13) L: Scott Bailes (8-12) S: Steve Farr (16) | Sixth | 11½ out |
| Tuesday, August 30 |
| » Defeated Royals (69-62), 4-1 | Royals Stadium (3-2) | 64-68 | |
| » W: Tom Candiotti (11-8) L: Ted Power (5-6) S: Brad Havens (1) | Sixth | 10½ out |
| Wednesday, August 31 |
| » Lost to Royals (70-62), 1-0 | Royals Stadium (3-3) | 64-69 | |
| » W: Charlie Leibrandt (10-11) L: Greg Swindell (14-13) | Sixth | 11½ out |
| Friday, September 2 |
| » Defeated White Sox (58-76), 4-3 | Cleveland Stadium (36-30) | 65-69 | |
| » W: Doug Jones (3-3) L: Ken Patterson (0-1) | Sixth | 10 out |
| » Major-league debuts: Luis Medina (Indians) Carlos Martinez (White Sox) |
| Former Indian Jim Bagby Jr. dies in Marietta, GA at the age of 72. |
| Sunday, September 4 |
| » Defeated White Sox (58-77), 3-2 | Cleveland Stadium (37-30) | 66-69 | Won 2 |
| » W: Brad Havens (2-2) L: Barry Jones (1-3) | Fifth | 9 out |
| » Lost to White Sox (59-77), 5-2 | Cleveland Stadium (37-31) | 66-70 | |
| » W: Bill Long (7-9) L: Doug Jones (3-4) S: Bobby Thigpen (29) | Fifth | 9 out |
| Monday, September 5 |
| » Lost to Yankees (71-64), 7-2 | Yankee Stadium (1-4) | 66-71 | Lost 2 |
| » W: Rick Rhoden (9-10) L: Don Gordon (2-3) | Sixth | 10 out |
| Tuesday, September 6 |
| » Defeated Yankees (71-65), 1-0 | Yankee Stadium (2-4) | 67-71 | |
| » W: Greg Swindell (15-13) L: Al Leiter (4-4) | Sixth | 10 out |
| Wednesday, September 7 |
| » Defeated Yankees (71-66), 5-4 | Yankee Stadium (3-4) | 68-71 | Won 2 |
| » W: Rod Nichols (1-4) L: Tommy John (9-7) S: Doug Jones (31) | Sixth | 9 out |
| Friday, September 9 |
| » Lost to Red Sox (78-62), 7-4 | Fenway Park (0-4) | 68-72 | |
| » W: Mike Boddicker (11-15) L: Rich Yett (8-5) S: Lee Smith (24) | Sixth | 10 out |
| » Major-league debuts: Mike Walker (Indians) |
| Saturday, September 10 |
| » Lost to Red Sox (79-62), 6-0 | Fenway Park (0-5) | 68-73 | Lost 2 |
| » W: Roger Clemens (16-10) L: Bud Black (4-4) | Sixth | 11 out |
| » Major-league debuts: Tom Lampkin (Indians) |
| Sunday, September 11 |
| » Defeated Red Sox (79-63), 4-2 | Fenway Park (1-5) | 69-73 | |
| » W: Tom Candiotti (12-8) L: Bob Stanley (6-4) S: Doug Jones (32) | Sixth | 10 out |
| Monday, September 12 |
| » Defeated Yankees (75-67), 8-6 | Cleveland Stadium (38-31) | 70-73 | Won 2 |
| » W: Greg Swindell (16-13) L: Tommy John (9-8) S: Doug Jones (33) | Sixth | 10 out |
| Tuesday, September 13 |
| » Lost to Yankees (76-67), 5-4 | Cleveland Stadium (38-32) | 70-74 | |
| » W: Neil Allen (5-2) L: Scott Bailes (8-13) S: Dave Righetti (21) | Sixth | 11 out |
| Wednesday, September 14 |
| » Lost to Yankees (77-67), 7-5 | Cleveland Stadium (38-33) | 70-75 | Lost 2 |
| » W: Richard Dotson (10-9) L: Rich Yett (8-6) S: Dale Mohorcic (6) | Sixth | 12 out |
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