| Saturday, February 20 |
| Former Cardinal Bob O'Farrell dies in Waukegan, IL at the age of 92. |
| Monday, April 4 |
| » Lost to Reds (1-0), 5-4 | Riverfront Stadium (0-1) | 0-1 | |
| » W: Pat Perry (1-0) L: Bob Forsch (0-1) | Third | 1 out |
| » Major-league debuts: Chris Sabo (Reds) |
| Thursday, April 7 |
| » Lost to Reds (2-0), 8-1 | Riverfront Stadium (0-2) | 0-2 | Lost 2 |
| » W: Danny Jackson (1-0) L: Jose DeLeon (0-1) | Fifth | 2 out |
| Friday, April 8 |
| » Lost to Pirates (2-1), 4-3 | Busch Stadium II (0-1) | 0-3 | Lost 3 |
| » W: Brian Fisher (1-0) L: Danny Cox (0-1) S: Jeff Robinson (2) | Fifth | 3 out |
| Saturday, April 9 |
| » Defeated Pirates (2-2), 3-0 | Busch Stadium II (1-1) | 1-3 | |
| » W: Greg Mathews (1-0) L: Bob Walk (0-1) S: Todd Worrell (1) | Fourth | 2 out |
| Sunday, April 10 |
| » Lost to Pirates (3-2), 5-3 | Busch Stadium II (1-2) | 1-4 | |
| » W: Bob Kipper (1-1) L: Todd Worrell (0-1) S: Jim Gott (1) | Fifth | 3 out |
| Monday, April 11 |
| » Lost to Cubs (5-1), 6-1 | Busch Stadium II (1-3) | 1-5 | Lost 2 |
| » W: Greg Maddux (2-0) L: Bob Forsch (0-2) | Fifth | 4 out |
| Tuesday, April 12 |
| » Defeated Cubs (5-2), 7-5 | Busch Stadium II (2-3) | 2-5 | |
| » W: Jose DeLeon (1-1) L: Drew Hall (0-1) S: Todd Worrell (2) | Fifth | 3 out |
| » Major-league debuts: Rolando Roomes (Cubs) |
| Wednesday, April 13 |
| » Defeated Cubs (5-3), 4-3 | Busch Stadium II (3-3) | 3-5 | Won 2 |
| » W: Danny Cox (1-1) L: Les Lancaster (0-1) S: Todd Worrell (3) | Fifth | 2½ out |
| Friday, April 15 |
| » Lost to Mets (6-3), 3-0 | Shea Stadium (0-1) | 3-6 | |
| » W: Dwight Gooden (3-0) L: Greg Mathews (1-1) | Second | 3 out |
| Saturday, April 16 |
| » Lost to Mets (7-3), 6-4 | Shea Stadium (0-2) | 3-7 | Lost 2 |
| » W: David Cone (1-0) L: Todd Worrell (0-2) S: Randy Myers (3) | Fourth | 4 out |
| Sunday, April 17 |
| » Lost to Mets (8-3), 3-2 | Shea Stadium (0-3) | 3-8 | Lost 3 |
| » W: Roger McDowell (1-0) L: Steve Peters (0-1) | Fourth | 5 out |
| Tuesday, April 19 |
| » Lost to Pirates (9-3), 3-0 | Three Rivers Stadium (0-1) | 3-9 | Lost 4 |
| » W: Brian Fisher (3-0) L: Danny Cox (1-2) | Fifth | 6 out |
| Wednesday, April 20 |
| » Lost to Pirates (10-3), 8-1 | Three Rivers Stadium (0-2) | 3-10 | Lost 5 |
| » W: Bob Walk (2-1) L: Greg Mathews (1-2) | Sixth | 7 out |
| Thursday, April 21 |
| » Defeated Pirates (10-4), 9-3 | Three Rivers Stadium (1-2) | 4-10 | |
| » W: Randy O'Neal (1-0) L: John Smiley (0-2) | Fifth | 6 out |
| Friday, April 22 |
| » Lost to Mets (10-5), 4-0 | Busch Stadium II (3-4) | 4-11 | |
| » W: Ron Darling (2-1) L: Jose DeLeon (1-2) | Fifth | 7 out |
| Saturday, April 23 |
| » Lost to Mets (11-5), 12-9 | Busch Stadium II (3-5) | 4-12 | Lost 2 |
| » W: Roger McDowell (2-0) L: Steve Peters (0-2) S: Randy Myers (4) | Sixth | 8 out |
| » Major-league debuts: Luis Alicea (Cardinals) |
| Sunday, April 24 |
| » Defeated Mets (11-6), 5-4 | Busch Stadium II (4-5) | 5-12 | |
| » W: Danny Cox (2-2) L: Jeff Innis (0-1) S: Todd Worrell (4) | Sixth | 8 out |
| Tuesday, April 26 |
| » Lost to Padres (8-9), 1-0 | San Diego/Jack Murphy Stadium (0-1) | 5-13 | |
| » W: Eric Show (1-3) L: Randy O'Neal (1-1) | Sixth | 9 out |
| Wednesday, April 27 |
| » Defeated Padres (8-10), 2-1 | San Diego/Jack Murphy Stadium (1-1) | 6-13 | |
| » W: Bob Forsch (1-2) L: Jimmy Jones (2-2) S: Todd Worrell (5) | Sixth | 8 out |
| Thursday, April 28 |
| » Defeated Padres (8-11), 6-4 | San Diego/Jack Murphy Stadium (2-1) | 7-13 | Won 2 |
| » W: Larry McWilliams (1-0) L: Greg Booker (0-1) S: Todd Worrell (6) | Fifth | 8 out |
| Friday, April 29 |
| » Lost to Dodgers (13-6), 6-4 | Dodger Stadium (0-1) | 7-14 | |
| » W: Orel Hershiser (5-0) L: Danny Cox (2-3) S: Jay Howell (2) | Sixth | 8 out |
| Saturday, April 30 |
| » Defeated Dodgers (13-7), 5-2 | Dodger Stadium (1-1) | 8-14 | |
| » W: Randy O'Neal (2-1) L: Fernando Valenzuela (2-3) S: Larry McWilliams (1) | Sixth | 8 out |
| Sunday, May 1 |
| » Defeated Dodgers (13-8), 9-0 | Dodger Stadium (2-1) | 9-14 | Won 2 |
| » W: John Tudor (1-0) L: Tim Leary (2-2) S: Scott Terry (1) | Fifth | 8 out |
| Monday, May 2 |
| » Defeated Giants (12-13), 5-1 | Candlestick Park (1-0) | 10-14 | Won 3 |
| » W: Jose DeLeon (2-2) L: Dave Dravecky (2-2) S: Todd Worrell (7) | Fifth | 7 out |
| Tuesday, May 3 |
| » Lost to Giants (13-13), 2-0 | Candlestick Park (1-1) | 10-15 | |
| » W: Atlee Hammaker (2-0) L: Scott Terry (0-1) S: Craig Lefferts (1) | Fifth | 7½ out |
| Wednesday, May 4 |
| » Defeated Giants (13-14), 5-3 | Candlestick Park (2-1) | 11-15 | |
| » W: Greg Mathews (2-2) L: Mike Krukow (1-2) S: Todd Worrell (8) | Fifth | 7½ out |
| Friday, May 6 |
| » Lost to Dodgers (17-8), 10-2 | Busch Stadium II (4-6) | 11-16 | |
| » W: Fernando Valenzuela (3-3) L: Randy O'Neal (2-2) | Fifth | 8½ out |
| Saturday, May 7 |
| » Defeated Dodgers (17-9), 2-1 | Busch Stadium II (5-6) | 12-16 | |
| » W: Todd Worrell (1-2) L: Jesse Orosco (1-1) | Fifth | 8½ out |
| Sunday, May 8 |
| » Lost to Dodgers (18-9), 12-6 | Busch Stadium II (5-7) | 12-17 | |
| » W: Don Sutton (2-2) L: Jose DeLeon (2-3) | Fifth | 9½ out |
| Monday, May 9 |
| » Defeated Padres (10-19), 7-1 | Busch Stadium II (6-7) | 13-17 | |
| » W: Larry McWilliams (2-0) L: Ed Whitson (2-2) | Fifth | 8½ out |
| Tuesday, May 10 |
| » Defeated Padres (10-20), 5-1 | Busch Stadium II (7-7) | 14-17 | Won 2 |
| » W: Bob Forsch (2-2) L: Andy Hawkins (3-3) S: Todd Worrell (9) | Fourth | 8½ out |
| Wednesday, May 11 |
| » Lost to Giants (16-17), 5-4 | Busch Stadium II (7-8) | 14-18 | |
| » W: Atlee Hammaker (3-0) L: Bob Forsch (2-3) | Fifth | 9½ out |
| Thursday, May 12 |
| » Defeated Giants (16-18), 13-12 | Busch Stadium II (8-8) | 15-18 | |
| » W: Scott Terry (1-1) L: Craig Lefferts (1-2) S: Todd Worrell (10) | Fifth | 9 out |
| Friday, May 13 |
| » Defeated Braves (9-22), 7-5 | Busch Stadium II (9-8) | 16-18 | Won 2 |
| » W: Jose DeLeon (3-3) L: Pete Smith (1-4) S: Ken Dayley (1) | Fourth | 8 out |
| Saturday, May 14 |
| » Lost to Braves (10-22), 7-5 | Busch Stadium II (9-9) | 16-19 | |
| » W: Rick Mahler (2-4) L: Jose Oquendo (0-1) | Fourth | 8 out |
| » Major-league debuts: Cris Carpenter (Cardinals) |
| Sunday, May 15 |
| » Defeated Braves (10-23), 7-6 | Busch Stadium II (10-9) | 17-19 | |
| » W: Todd Worrell (2-2) L: Bruce Sutter (1-1) | Fourth | 7 out |
| Tuesday, May 17 |
| » Defeated Cubs (18-18), 3-0 | Wrigley Field (1-0) | 18-19 | Won 2 |
| » W: Scott Terry (2-1) L: Greg Maddux (6-3) S: Todd Worrell (11) | Fourth | 7½ out |
| Wednesday, May 18 |
| » Defeated Cubs (18-19), 4-1 | Wrigley Field (2-0) | 19-19 | Won 3 |
| » W: Bob Forsch (3-3) L: Les Lancaster (1-4) S: Todd Worrell (12) | Third | 7½ out |
| Thursday, May 19 |
| » Defeated Cubs (18-20), 5-1 | Wrigley Field (3-0) | 20-19 | Won 4 |
| » W: Cris Carpenter (1-0) L: Al Nipper (0-2) | Third | 7½ out |
| Friday, May 20 |
| » Lost to Astros (23-15), 5-3 | Busch Stadium II (10-10) | 20-20 | |
| » W: Bob Knepper (6-0) L: Scott Terry (2-2) S: Dave Smith (9) | Third | 8½ out |
| Saturday, May 21 |
| » Defeated Astros (23-16), 7-4 | Busch Stadium II (11-10) | 21-20 | |
| » W: Bob Forsch (4-3) L: Joaquin Andujar (0-1) | Third | 8½ out |
| Sunday, May 22 |
| » Lost to Astros (24-16), 2-1 | Busch Stadium II (11-11) | 21-21 | |
| » W: Juan Agosto (2-0) L: Ken Dayley (0-1) S: Larry Andersen (1) | Third | 9½ out |
| Monday, May 23 |
| » Lost to Reds (22-21), 8-3 | Busch Stadium II (11-12) | 21-22 | Lost 2 |
| » W: Dennis Rasmussen (2-4) L: Jose DeLeon (3-4) | Fourth | 10 out |
| Tuesday, May 24 |
| » Defeated Reds (22-22), 3-2 | Busch Stadium II (12-12) | 22-22 | |
| » W: Ken Dayley (1-1) L: John Franco (1-4) | Third | 9 out |
| Wednesday, May 25 |
| » Defeated Reds (22-23), 6-0 | Busch Stadium II (13-12) | 23-22 | Won 2 |
| » W: Larry McWilliams (3-0) L: Mario Soto (3-3) | Third | 9 out |
| Friday, May 27 |
| » Defeated Braves (14-29), 5-2 | Atlanta-Fulton County Stadium (1-0) | 24-22 | Won 3 |
| » W: Steve Peters (1-2) L: Jose Alvarez (1-1) S: Todd Worrell (13) | Third | 7½ out |
| Saturday, May 28 |
| » Lost to Braves (15-29), 2-1 | Atlanta-Fulton County Stadium (1-1) | 24-23 | |
| » W: Rick Mahler (6-4) L: John Tudor (1-1) S: Bruce Sutter (7) | Third | 8½ out |
| Sunday, May 29 |
| » Defeated Braves (15-30), 3-1 | Atlanta-Fulton County Stadium (2-1) | 25-23 | |
| » W: Jose DeLeon (4-4) L: Kevin Coffman (2-5) S: Ken Dayley (2) | Third | 7½ out |
| Monday, May 30 |
| » Lost to Astros (27-20), 5-4 | Astrodome (0-1) | 25-24 | |
| » W: Jim Deshaies (4-2) L: Scott Terry (2-3) S: Dave Smith (10) | Third | 8½ out |
| Tuesday, May 31 |
| » Defeated Astros (27-21), 9-7 | Astrodome (1-1) | 26-24 | |
| » W: Larry McWilliams (4-0) L: Bob Knepper (6-1) S: Todd Worrell (14) | Third | 8½ out |
| Wednesday, June 1 |
| » Defeated Astros (27-22), 3-2 | Astrodome (2-1) | 27-24 | Won 2 |
| » W: Steve Peters (2-2) L: Jeff Heathcock (0-3) S: Todd Worrell (15) | Third | 7½ out |
| Thursday, June 2 |
| » Defeated Phillies (20-29), 3-2 | Veteran's Stadium (1-0) | 28-24 | Won 3 |
| » W: John Costello (1-0) L: Danny Clay (0-1) | Third | 7½ out |
| » Major-league debuts: John Costello (Cardinals) |
| Friday, June 3 |
| » Defeated Phillies (20-30), 5-4 | Veteran's Stadium (2-0) | 29-24 | Won 4 |
| » W: Todd Worrell (3-2) L: Greg Harris (1-2) | Third | 6½ out |
| Saturday, June 4 |
| » Defeated Phillies (20-31), 8-1 | Veteran's Stadium (3-0) | 30-24 | Won 5 |
| » W: Cris Carpenter (2-0) L: Shane Rawley (4-6) | Third | 6½ out |
| Sunday, June 5 |
| » Lost to Phillies (21-31), 6-3 | Veteran's Stadium (3-1) | 30-25 | |
| » W: David Palmer (1-5) L: Randy O'Neal (2-3) S: Steve Bedrosian (4) | Third | 7½ out |
| Monday, June 6 |
| » Lost to Mets (38-17), 6-2 | Busch Stadium II (13-13) | 30-26 | Lost 2 |
| » W: Sid Fernandez (3-5) L: Larry McWilliams (4-1) S: Randy Myers (9) | Third | 8½ out |
| Tuesday, June 7 |
| » Defeated Mets (38-18), 4-1 | Busch Stadium II (14-13) | 31-26 | |
| » W: John Tudor (2-1) L: David Cone (7-1) S: Ken Dayley (3) | Third | 7½ out |
| Wednesday, June 8 |
| » Defeated Mets (38-19), 5-2 | Busch Stadium II (15-13) | 32-26 | Won 2 |
| » W: Steve Peters (3-2) L: Roger McDowell (3-1) S: Todd Worrell (16) | Third | 6½ out |
| Friday, June 10 |
| » Lost to Cubs (29-29), 7-3 | Busch Stadium II (15-14) | 32-27 | |
| » W: Jeff Pico (2-1) L: Cris Carpenter (2-1) | Third | 6½ out |
| Saturday, June 11 |
| » Lost to Cubs (30-29), 2-0 | Busch Stadium II (15-15) | 32-28 | Lost 2 |
| » W: Rick Sutcliffe (4-4) L: Joe Magrane (0-1) S: Rich Gossage (8) | Third | 6½ out |
| Sunday, June 12 |
| » Lost to Cubs (31-29), 4-3 | Busch Stadium II (15-16) | 32-29 | Lost 3 |
| » W: Greg Maddux (11-3) L: John Tudor (2-2) S: Pat Perry (1) | Third | 6½ out |
| Monday, June 13 |
| » Lost to Mets (39-22), 2-1 | Shea Stadium (0-4) | 32-30 | Lost 4 |
| » W: Randy Myers (5-0) L: Ken Dayley (1-2) | Third | 7½ out |
| Tuesday, June 14 |
| » Lost to Mets (40-22), 5-0 | Shea Stadium (0-5) | 32-31 | Lost 5 |
| » W: Bob Ojeda (5-5) L: Jose DeLeon (4-5) | Third | 8½ out |
| Wednesday, June 15 |
| » Lost to Mets (41-22), 6-4 | Shea Stadium (0-6) | 32-32 | Lost 6 |
| » W: Ron Darling (7-4) L: Cris Carpenter (2-2) S: Randy Myers (10) | Fourth | 9½ out |
| Friday, June 17 |
| » Defeated Pirates (36-29), 7-3 | Three Rivers Stadium (2-2) | 33-32 | |
| » W: Joe Magrane (1-1) L: Mike Dunne (4-5) | Fourth | 8½ out |
| Saturday, June 18 |
| » Defeated Pirates (36-30), 6-3 | Three Rivers Stadium (3-2) | 34-32 | Won 2 |
| » W: John Tudor (3-2) L: Brian Fisher (4-5) S: Scott Terry (2) | Fourth | 8½ out |
| Sunday, June 19 |
| » Lost to Pirates (37-30), 3-2 | Three Rivers Stadium (3-3) | 34-33 | |
| » W: Bob Walk (8-4) L: Larry McWilliams (4-2) S: Jim Gott (7) | Fourth | 9½ out |
| Monday, June 20 |
| » Lost to Expos (32-35), 3-2 | Stade Olympique (0-1) | 34-34 | Lost 2 |
| » W: Floyd Youmans (3-6) L: Ken Dayley (1-3) S: Jeff Parrett (5) | Fourth | 9½ out |
| Tuesday, June 21 |
| » Lost to Expos (33-35), 7-0 | Stade Olympique (0-2) | 34-35 | Lost 3 |
| » W: Pascual Perez (4-3) L: Cris Carpenter (2-3) | Fourth | 10½ out |
| Wednesday, June 22 |
| » Lost to Expos (34-35), 6-2 | Stade Olympique (0-3) | 34-36 | Lost 4 |
| » W: Bryn Smith (5-5) L: Joe Magrane (1-2) S: Joe Hesketh (2) | Fifth | 11½ out |
| Thursday, June 23 |
| » Defeated Phillies (31-38), 2-0 | Busch Stadium II (16-16) | 35-36 | |
| » W: John Tudor (4-2) L: Shane Rawley (5-7) | Fourth | 10½ out |
| » Major-league debuts: Mike Fitzgerald (Cardinals) |
| Friday, June 24 |
| » Lost to Phillies (32-38), 7-6 | Busch Stadium II (16-17) | 35-37 | |
| » W: Bruce Ruffin (5-6) L: Todd Worrell (3-3) S: Steve Bedrosian (12) | Fourth | 11½ out |
| Saturday, June 25 |
| » Defeated Phillies (32-39), 4-1 | Busch Stadium II (17-17) | 36-37 | |
| » W: Jose DeLeon (5-5) L: Kevin Gross (8-3) | Fourth | 10½ out |
| Sunday, June 26 |
| » Lost to Phillies (33-39), 7-5 | Busch Stadium II (17-18) | 36-38 | |
| » W: Steve Bedrosian (1-2) L: Larry McWilliams (4-3) S: Bruce Ruffin (1) | Fourth | 10½ out |
| Monday, June 27 |
| » Lost to Expos (35-39), 6-3 | Busch Stadium II (17-19) | 36-39 | Lost 2 |
| » W: Jeff Parrett (6-2) L: Steve Peters (3-3) S: Bob McClure (2) | Fourth | 10½ out |
| Tuesday, June 28 |
| » Defeated Expos (35-40), 5-4 | Busch Stadium II (18-19) | 37-39 | |
| » W: Ken Dayley (2-3) L: Joe Hesketh (1-1) | Fourth | 10½ out |
| Wednesday, June 29 |
| » Lost to Expos (36-40), 3-2 | Busch Stadium II (18-20) | 37-40 | |
| » W: Jeff Parrett (7-2) L: Todd Worrell (3-4) | Fourth | 11½ out |
| Friday, July 1 |
| » Lost to Padres (35-45), 5-1 | San Diego/Jack Murphy Stadium (2-2) | 37-41 | Lost 2 |
| » W: Andy Hawkins (8-6) L: Jose DeLeon (5-6) | Fifth | 12½ out |
| Former Cardinal Ed Sauer dies in Thousand Oaks, CA at the age of 70. |
| Saturday, July 2 |
| » Lost to Padres (36-45), 7-5 | San Diego/Jack Murphy Stadium (2-3) | 37-42 | Lost 3 |
| » W: Mark Grant (2-6) L: Ken Dayley (2-4) S: Mark Davis (15) | Fifth | 13½ out |
| Sunday, July 3 |
| » Defeated Padres (36-46), 5-4 | San Diego/Jack Murphy Stadium (3-3) | 38-42 | |
| » W: Todd Worrell (4-4) L: Lance McCullers (1-5) | Fifth | 13½ out |
| Monday, July 4 |
| » Lost to Dodgers (46-33), 5-3 | Dodger Stadium (2-2) | 38-43 | |
| » W: Alejandro Pena (3-3) L: John Tudor (4-3) S: Tim Belcher (3) | Fifth | 13½ out |
| Tuesday, July 5 |
| » Lost to Dodgers (47-33), 6-3 | Dodger Stadium (2-3) | 38-44 | Lost 2 |
| » W: Orel Hershiser (13-3) L: Danny Cox (2-4) S: Tim Belcher (4) | Fifth | 13½ out |
| Wednesday, July 6 |
| » Lost to Dodgers (48-33), 7-3 | Dodger Stadium (2-4) | 38-45 | Lost 3 |
| » W: Tim Crews (3-0) L: Todd Worrell (4-5) | Fifth | 14½ out |
| Friday, July 8 |
| » Lost to Giants (44-39), 1-0 | Candlestick Park (2-2) | 38-46 | Lost 4 |
| » W: Mike LaCoss (7-6) L: Joe Magrane (1-3) | Fifth | 14½ out |
| Saturday, July 9 |
| » Lost to Giants (45-39), 21-2 | Candlestick Park (2-3) | 38-47 | Lost 5 |
| » W: Kelly Downs (8-7) L: John Tudor (4-4) | Fifth | 14½ out |
| Sunday, July 10 |
| » Lost to Giants (46-39), 2-1 | Candlestick Park (2-4) | 38-48 | Lost 6 |
| » W: Terry Mulholland (2-0) L: Danny Cox (2-5) | Fifth | 14½ out |
| Thursday, July 14 |
| » Lost to Padres (40-49), 3-1 | Busch Stadium II (18-21) | 38-49 | Lost 7 |
| » W: Andy Hawkins (9-7) L: Jose DeLeon (5-7) | Fifth | 15½ out |
| Friday, July 15 |
| » Lost to Padres (41-49), 7-3 | Busch Stadium II (18-22) | 38-50 | Lost 8 |
| » W: Mark Davis (4-6) L: Todd Worrell (4-6) | Fifth | 15½ out |
| Saturday, July 16 |
| » Defeated Padres (41-50), 3-2 | Busch Stadium II (19-22) | 39-50 | |
| » W: John Costello (2-0) L: Mark Davis (4-7) | Fifth | 15½ out |
| Sunday, July 17 |
| » Lost to Padres (42-50), 3-1 | Busch Stadium II (19-23) | 39-51 | |
| » W: Eric Show (7-9) L: Joe Magrane (1-4) | Fifth | 16½ out |
| Monday, July 18 |
| » Lost to Dodgers (54-36), 1-0 | Busch Stadium II (19-24) | 39-52 | Lost 2 |
| » W: Tim Leary (9-6) L: Todd Worrell (4-7) | Fifth | 16½ out |
| Tuesday, July 19 |
| » Defeated Dodgers (54-37), 3-2 | Busch Stadium II (20-24) | 40-52 | |
| » W: Jose DeLeon (6-7) L: William Brennan (0-1) S: Todd Worrell (17) | Fifth | 15½ out |
| Wednesday, July 20 |
| » Defeated Dodgers (54-38), 8-7 | Busch Stadium II (21-24) | 41-52 | Won 2 |
| » W: John Costello (3-0) L: Fernando Valenzuela (5-7) S: Todd Worrell (18) | Fifth | 15 out |
| Thursday, July 21 |
| » Defeated Giants (48-45), 6-4 | Busch Stadium II (22-24) | 42-52 | Won 3 |
| » W: Danny Cox (3-5) L: Joe Price (0-4) S: Todd Worrell (19) | Fifth | 14½ out |
| Friday, July 22 |
| » Defeated Giants (48-46), 4-2 | Busch Stadium II (23-24) | 43-52 | Won 4 |
| » W: Dan Quisenberry (1-1) L: Craig Lefferts (2-7) | Fifth | 15 out |
| Saturday, July 23 |
| » Lost to Giants (49-46), 6-5 | Busch Stadium II (23-25) | 43-53 | |
| » W: Scott Garrelts (2-4) L: Todd Worrell (4-8) | Fifth | 15 out |
| Sunday, July 24 |
| » Lost to Giants (50-46), 5-0 | Busch Stadium II (23-26) | 43-54 | Lost 2 |
| » W: Rick Reuschel (13-5) L: Jose DeLeon (6-8) | Fifth | 15 out |
| Former Cardinal Joe Orengo dies in San Francisco, CA at the age of 74. |
| Monday, July 25 |
| » Defeated Pirates (56-42), 5-1 | Busch Stadium II (24-26) | 44-54 | |
| » W: John Tudor (5-4) L: Bob Walk (11-5) | Fifth | 14 out |
| Tuesday, July 26 |
| » Lost to Pirates (57-42), 2-1 | Busch Stadium II (24-27) | 44-55 | |
| » W: Doug Drabek (9-5) L: Danny Cox (3-6) S: Jim Gott (16) | Fifth | 15 out |
| » Major-league debuts: Tim Jones (Cardinals) |
| Wednesday, July 27 |
| » Lost to Pirates (58-42), 3-2 | Busch Stadium II (24-28) | 44-56 | Lost 2 |
| » W: Jeff Robinson (8-2) L: Ken Dayley (2-5) S: Jim Gott (17) | Fifth | 16 out |
| Thursday, July 28 |
| » Lost to Expos (53-47), 4-3 | Stade Olympique (0-4) | 44-57 | Lost 3 |
| » W: Tim Burke (3-2) L: Larry McWilliams (4-4) | Fifth | 16½ out |
| Friday, July 29 |
| » Defeated Expos (53-48), 7-5 | Stade Olympique (1-4) | 45-57 | |
| » W: Jose DeLeon (7-8) L: Pascual Perez (7-5) S: Todd Worrell (20) | Fifth | 16½ out |
| Saturday, July 30 |
| » Lost to Expos (54-48), 2-1 | Stade Olympique (1-5) | 45-58 | |
| » W: Joe Hesketh (3-1) L: Todd Worrell (4-9) | Fifth | 17½ out |
| Sunday, July 31 |
| » Lost to Expos (55-48), 2-0 | Stade Olympique (1-6) | 45-59 | Lost 2 |
| » W: Dennis Martinez (12-7) L: Danny Cox (3-7) | Fifth | 18½ out |
| Tuesday, August 2 |
| » Lost to Phillies (46-59), 2-0 | Busch Stadium II (24-29) | 45-60 | Lost 3 |
| » W: David Palmer (6-8) L: Joe Magrane (1-5) | Sixth | 19 out |
| Wednesday, August 3 |
| » Defeated Phillies (46-60), 4-2 | Busch Stadium II (25-29) | 46-60 | |
| » W: Bob Forsch (5-3) L: Kevin Gross (10-8) S: Scott Terry (3) | Fifth | 18 out |
| Thursday, August 4 |
| » Defeated Phillies (46-61), 9-2 | Busch Stadium II (26-29) | 47-60 | Won 2 |
| » W: Jose DeLeon (8-8) L: Shane Rawley (5-13) | Fifth | 17 out |
| Friday, August 5 |
| » Lost to Expos (58-49), 3-1 | Busch Stadium II (26-30) | 47-61 | |
| » W: Dennis Martinez (13-7) L: John Tudor (5-5) | Fifth | 18 out |
| Saturday, August 6 |
| » Lost to Expos (59-49), 5-4 | Busch Stadium II (26-31) | 47-62 | Lost 2 |
| » W: Brian Holman (2-3) L: Danny Cox (3-8) S: Tim Burke (12) | Fifth | 19 out |
| Sunday, August 7 |
| » Lost to Expos (60-49), 11-5 | Busch Stadium II (26-32) | 47-63 | Lost 3 |
| » W: Bryn Smith (8-6) L: Joe Magrane (1-6) S: Tim Barrett (1) | Sixth | 20 out |
| Monday, August 8 |
| » Defeated Expos (60-50), 4-2 | Busch Stadium II (27-32) | 48-63 | |
| » W: Bob Forsch (6-3) L: Pascual Perez (8-6) S: Todd Worrell (21) | Sixth | 19 out |
| Tuesday, August 9 |
| » Defeated Phillies (48-63), 7-3 | Veteran's Stadium (4-1) | 49-63 | Won 2 |
| » W: Dan Quisenberry (2-1) L: Steve Bedrosian (1-5) | Fifth | 18 out |
| Wednesday, August 10 |
| » Defeated Phillies (48-64), 1-0 | Veteran's Stadium (5-1) | 50-63 | Won 3 |
| » W: John Tudor (6-5) L: Don Carman (9-6) S: Todd Worrell (22) | Fifth | 17 out |
| Thursday, August 11 |
| » Lost to Phillies (49-64), 1-0 | Veteran's Stadium (5-2) | 50-64 | |
| » W: Steve Bedrosian (2-5) L: John Costello (3-1) | Fifth | 18 out |
| Friday, August 12 |
| » Defeated Cubs (55-58), 4-0 | Wrigley Field (4-0) | 51-64 | |
| » W: Joe Magrane (2-6) L: Rick Sutcliffe (9-10) | Fifth | 17 out |
| Saturday, August 13 |
| » Lost to Cubs (56-58), 5-1 | Wrigley Field (4-1) | 51-65 | |
| » W: Jamie Moyer (6-11) L: Bob Forsch (6-4) | Fifth | 17 out |
| Sunday, August 14 |
| » Lost to Cubs (57-58), 8-3 | Wrigley Field (4-2) | 51-66 | Lost 2 |
| » W: Mike Bielecki (2-0) L: Ken Dayley (2-6) S: Les Lancaster (5) | Fifth | 18½ out |
| Tuesday, August 16 |
| » Defeated Astros (64-55), 3-0 | Busch Stadium II (28-32) | 52-66 | |
| » W: Scott Terry (3-3) L: Jim Deshaies (8-10) S: Ken Dayley (4) | Fifth | 18½ out |
| Wednesday, August 17 |
| » Lost to Astros (65-55), 1-0 | Busch Stadium II (28-33) | 52-67 | |
| » W: Dave Meads (2-0) L: Joe Magrane (2-7) S: Dave Smith (22) | Fifth | 18½ out |
| Thursday, August 18 |
| » Defeated Astros (65-56), 2-1 | Busch Stadium II (29-33) | 53-67 | |
| » W: Bob Forsch (7-4) L: Mike Scott (13-4) S: Todd Worrell (23) | Fifth | 17½ out |
| Friday, August 19 |
| » Defeated Reds (61-59), 10-4 | Busch Stadium II (30-33) | 54-67 | Won 2 |
| » W: John Costello (4-1) L: Norm Charlton (0-1) S: Todd Worrell (24) | Fifth | 16½ out |
| » Major-league debuts: Norm Charlton (Reds) |
| Saturday, August 20 |
| » Lost to Reds (62-59), 6-2 | Busch Stadium II (30-34) | 54-68 | |
| » W: Tom Browning (12-4) L: Greg Mathews (2-3) S: Frank Williams (1) | Fifth | 17 out |
| Sunday, August 21 |
| » Defeated Reds (62-60), 7-1 | Busch Stadium II (31-34) | 55-68 | |
| » W: Scott Terry (4-3) L: Tim Birtsas (1-3) | Fifth | 16 out |
| Monday, August 22 |
| » Lost to Braves (43-81), 5-3 | Busch Stadium II (31-35) | 55-69 | |
| » W: Tom Glavine (5-14) L: Joe Magrane (2-8) S: Jose Alvarez (2) | Fifth | 17 out |
| Tuesday, August 23 |
| » Defeated Braves (43-82), 7-0 | Busch Stadium II (32-35) | 56-69 | |
| » W: Bob Forsch (8-4) L: John Smoltz (1-4) | Fifth | 17 out |
| Wednesday, August 24 |
| » Defeated Braves (43-83), 5-3 | Busch Stadium II (33-35) | 57-69 | Won 2 |
| » W: Todd Worrell (5-9) L: Bruce Sutter (1-4) | Fifth | 17 out |
| Thursday, August 25 |
| » Lost to Reds (65-61), 4-1 | Riverfront Stadium (0-3) | 57-70 | |
| » W: Keith Brown (1-0) L: Greg Mathews (2-4) S: John Franco (27) | Fifth | 17½ out |
| » Major-league debuts: Keith Brown (Reds) |
| Friday, August 26 |
| » Defeated Reds (65-62), 4-2 | Riverfront Stadium (1-3) | 58-70 | |
| » W: Scott Terry (5-3) L: Danny Jackson (18-6) S: Todd Worrell (25) | Fifth | 17½ out |
| Saturday, August 27 |
| » Lost to Reds (66-62), 3-2 | Riverfront Stadium (1-4) | 58-71 | |
| » W: John Franco (5-5) L: Larry McWilliams (4-5) | Fifth | 18½ out |
| Sunday, August 28 |
| » Defeated Reds (66-63), 5-3 | Riverfront Stadium (2-4) | 59-71 | |
| » W: Bob Forsch (9-4) L: Tom Browning (13-5) S: Todd Worrell (26) | Fifth | 17½ out |
| Monday, August 29 |
| » Defeated Braves (45-86), 3-2 | Atlanta-Fulton County Stadium (3-1) | 60-71 | Won 2 |
| » W: Jose DeLeon (9-8) L: Rick Mahler (9-12) S: John Costello (1) | Fifth | 17½ out |
| Tuesday, August 30 |
| » Defeated Braves (45-87), 9-1 | Atlanta-Fulton County Stadium (4-1) | 61-71 | Won 3 |
| » W: Greg Mathews (3-4) L: German Jimenez (1-6) | Fifth | 17½ out |
| Wednesday, August 31 |
| » Defeated Braves (45-88), 6-4 | Atlanta-Fulton County Stadium (5-1) | 62-71 | Won 4 |
| » W: Scott Terry (6-3) L: Pete Smith (7-13) S: Todd Worrell (27) | Fifth | 16½ out |
| Friday, September 2 |
| » Defeated Astros (71-63), 2-0 | Astrodome (3-1) | 63-71 | Won 5 |
| » W: Joe Magrane (3-8) L: Mike Scott (13-5) | Fifth | 16½ out |
| Saturday, September 3 |
| » Lost to Astros (72-63), 10-1 | Astrodome (3-2) | 63-72 | |
| » W: Nolan Ryan (10-11) L: Larry McWilliams (4-6) | Fifth | 17½ out |
| » Major-league debuts: Brian Meyer (Astros) Ken Hill (Cardinals) |
| Sunday, September 4 |
| » Lost to Astros (73-63), 4-3 | Astrodome (3-3) | 63-73 | Lost 2 |
| » W: Bob Knepper (13-4) L: Greg Mathews (3-5) S: Dave Smith (24) | Fifth | 18 out |
| Monday, September 5 |
| » Defeated Expos (70-66), 6-2 | Busch Stadium II (34-35) | 64-73 | |
| » W: Scott Terry (7-3) L: John Dopson (3-9) | Fifth | 18 out |
| Tuesday, September 6 |
| » Defeated Expos (70-67), 1-0 | Busch Stadium II (35-35) | 65-73 | Won 2 |
| » W: Jose DeLeon (10-8) L: Dennis Martinez (15-11) | Fifth | 17 out |
| Wednesday, September 7 |
| » Defeated Phillies (56-82), 5-0 | Busch Stadium II (36-35) | 66-73 | Won 3 |
| » W: Joe Magrane (4-8) L: Don Carman (9-11) | Fifth | 16 out |
| Thursday, September 8 |
| » Defeated Phillies (56-83), 1-0 | Busch Stadium II (37-35) | 67-73 | Won 4 |
| » W: Larry McWilliams (5-6) L: Kevin Gross (11-13) S: Todd Worrell (28) | Fifth | 16 out |
| Friday, September 9 |
| » Defeated Cubs (68-72), 6-2 | Busch Stadium II (38-35) | 68-73 | Won 5 |
| » W: Greg Mathews (4-5) L: Calvin Schiraldi (8-11) S: Todd Worrell (29) | Fifth | 16 out |
| Saturday, September 10 |
| » Defeated Cubs (68-73), 9-3 | Busch Stadium II (39-35) | 69-73 | Won 6 |
| » W: Scott Terry (8-3) L: Rick Sutcliffe (12-12) | Fourth | 16 out |
| Sunday, September 11 |
| » Defeated Cubs (68-74), 3-2 | Busch Stadium II (40-35) | 70-73 | Won 7 |
| » W: Jose DeLeon (11-8) L: Mike Harkey (0-1) S: Ken Dayley (5) | Fourth | 16 out |
| Monday, September 12 |
| » Lost to Expos (72-71), 14-2 | Stade Olympique (1-7) | 70-74 | |
| » W: Bryn Smith (11-9) L: Joe Magrane (4-9) S: Mike Smith (1) | Fourth | 17 out |
| Tuesday, September 13 |
| » Lost to Expos (73-71), 7-1 | Stade Olympique (1-8) | 70-75 | Lost 2 |
| » W: Pascual Perez (11-6) L: Larry McWilliams (5-7) | Fourth | 17 out |
| Wednesday, September 14 |
| » Lost to Phillies (59-86), 9-2 | Veteran's Stadium (5-3) | 70-76 | Lost 3 |
| » W: Bob Sebra (1-2) L: Greg Mathews (4-6) | Fourth | 18 out |
| Thursday, September 15 |
| » Defeated Phillies (59-87), 3-1 | Veteran's Stadium (6-3) | 71-76 | |
| » W: Scott Terry (9-3) L: Shane Rawley (7-15) S: Todd Worrell (30) | Fourth | 18 out |
| Friday, September 16 |
| » Defeated Cubs (69-78), 3-0 | Wrigley Field (5-2) | 72-76 | Won 2 |
| » W: Jose DeLeon (12-8) L: Mike Harkey (0-2) S: Todd Worrell (31) | Fourth | 18 out |
| Saturday, September 17 |
| » Lost to Cubs (70-78), 6-4 | Wrigley Field (5-3) | 72-77 | |
| » W: Jeff Pico (6-7) L: John Costello (4-2) | Fourth | 19 out |
| Sunday, September 18 |
| » Defeated Cubs (70-79), 5-4 | Wrigley Field (6-3) | 73-77 | |
| » W: Larry McWilliams (6-7) L: Greg Maddux (17-8) S: Todd Worrell (32) | Fourth | 19 out |
| Monday, September 19 |
| » Lost to Pirates (80-69), 5-4 | Busch Stadium II (40-36) | 73-78 | |
| » W: Jeff Robinson (11-5) L: Ken Dayley (2-7) S: Jim Gott (31) | Fourth | 19½ out |
| Tuesday, September 20 |
| » Lost to Pirates (81-69), 5-1 | Busch Stadium II (40-37) | 73-79 | Lost 2 |
| » W: Scott Medvin (2-0) L: Scott Terry (9-4) S: Jim Gott (32) | Fourth | 20½ out |
| Wednesday, September 21 |
| » Lost to Pirates (82-69), 5-0 | Busch Stadium II (40-38) | 73-80 | Lost 3 |
| » W: John Smiley (12-10) L: Jose DeLeon (12-9) | Fourth | 21½ out |
| Friday, September 23 |
| » Defeated Mets (94-58), 2-1 | Busch Stadium II (41-38) | 74-80 | |
| » W: John Costello (5-2) L: Dwight Gooden (18-8) | Fourth | 21 out |
| Saturday, September 24 |
| » Lost to Mets (95-58), 14-1 | Busch Stadium II (41-39) | 74-81 | |
| » W: David West (1-0) L: Larry McWilliams (6-8) | Fourth | 22 out |
| » Major-league debuts: David West (Mets) |
| Sunday, September 25 |
| » Lost to Mets (96-58), 9-7 | Busch Stadium II (41-40) | 74-82 | Lost 2 |
| » W: David Cone (19-3) L: Scott Terry (9-5) S: Randy Myers (25) | Fourth | 23 out |
| Monday, September 26 |
| » Defeated Pirates (83-72), 7-1 | Three Rivers Stadium (4-3) | 75-82 | |
| » W: Jose DeLeon (13-9) L: Dave LaPoint (14-13) | Fourth | 23 out |
| Tuesday, September 27 |
| » Lost to Pirates (84-72), 3-2 | Three Rivers Stadium (4-4) | 75-83 | |
| » W: John Smiley (13-10) L: Ken Hill (0-1) S: Jim Gott (34) | Fourth | 23 out |
| Wednesday, September 28 |
| » Defeated Pirates (84-73), 2-1 | Three Rivers Stadium (5-4) | 76-83 | |
| » W: Joe Magrane (5-9) L: Doug Drabek (15-7) | Fourth | 22 out |
| Friday, September 30 |
| » Lost to Mets (98-60), 4-2 | Shea Stadium (0-7) | 76-84 | |
| » W: David Cone (20-3) L: Scott Terry (9-6) | Fourth | 23 out |
| Saturday, October 1 |
| » Lost to Mets (99-60), 6-3 | Shea Stadium (0-8) | 76-85 | Lost 2 |
| » W: Sid Fernandez (12-10) L: Jose DeLeon (13-10) S: Bob McClure (3) | Fourth | 24 out |
| Sunday, October 2 |
| » Lost to Mets (100-60), 7-5 | Shea Stadium (0-9) | 76-86 | Lost 3 |
| » W: Ron Darling (17-9) L: Larry McWilliams (6-9) S: Randy Myers (26) | Fifth | 25 out |
| Friday, October 14 |
| Former Cardinal Vic Raschi dies in Groveland, NY at the age of 70. |
| Wednesday, November 9 |
| Former Cardinal Bob Weiland dies in Chicago, IL at the age of 83. |
Game information provided by Retrosheet (www.retrosheet.org) |