| Monday, April 4 |
| » Defeated Royals (0-1), 5-3 | Royals Stadium (1-0) | 1-0 | |
| » W: Jimmy Key (1-0) L: Bret Saberhagen (0-1) S: Tom Henke (1) | First | -- |
| » Major-league debuts: Sil Campusano (Blue Jays) |
| Wednesday, April 6 |
| » Defeated Royals (0-2), 11-4 | Royals Stadium (2-0) | 2-0 | Won 2 |
| » W: Mike Flanagan (1-0) L: Charlie Leibrandt (0-1) | First | -- |
| » Major-league debuts: Pat Borders and Todd Stottlemyre (Blue Jays) |
| Thursday, April 7 |
| » Lost to Royals (1-2), 7-4 | Royals Stadium (2-1) | 2-1 | |
| » W: Mark Gubicza (1-0) L: Jim Clancy (0-1) | Second | ½ out |
| Friday, April 8 |
| » Lost to Twins (1-2), 6-3 | Hubert H. Humphrey Metrodome (0-1) | 2-2 | Lost 2 |
| » W: Bert Blyleven (1-0) L: Dave Stieb (0-1) S: Jeff Reardon (1) | Fourth | 1½ out |
| Saturday, April 9 |
| » Defeated Twins (1-3), 10-0 | Hubert H. Humphrey Metrodome (1-1) | 3-2 | |
| » W: Jimmy Key (2-0) L: Charlie Lea (0-1) S: Duane Ward (1) | Third | 1½ out |
| Sunday, April 10 |
| » Lost to Twins (2-3), 4-2 | Hubert H. Humphrey Metrodome (1-2) | 3-3 | |
| » W: Frank Viola (1-1) L: Todd Stottlemyre (0-1) S: Jeff Reardon (2) | Third | 2½ out |
| Monday, April 11 |
| » Defeated Yankees (5-1), 17-9 | Exhibition Stadium (1-0) | 4-3 | |
| » W: David Wells (1-0) L: Rick Rhoden (1-1) | Third | 2 out |
| Tuesday, April 12 |
| » Lost to Yankees (6-1), 12-3 | Exhibition Stadium (1-1) | 4-4 | |
| » W: John Candelaria (1-0) L: Jim Clancy (0-2) | Fourth | 2½ out |
| Wednesday, April 13 |
| » Lost to Yankees (7-1), 5-1 | Exhibition Stadium (1-2) | 4-5 | Lost 2 |
| » W: Richard Dotson (2-0) L: Dave Stieb (0-2) | Fifth | 3½ out |
| Thursday, April 14 |
| » Lost to Yankees (8-1), 7-3 | Exhibition Stadium (1-3) | 4-6 | Lost 3 |
| » W: Al Leiter (2-0) L: Jimmy Key (2-1) | Fifth | 4½ out |
| Saturday, April 16 |
| » Lost to Twins (4-5), 3-2 | Exhibition Stadium (1-4) | 4-7 | Lost 4 |
| » W: Juan Berenguer (1-2) L: David Wells (1-1) S: Jeff Reardon (4) | Fifth | 5½ out |
| Sunday, April 17 |
| » Defeated Twins (4-6), 2-0 | Exhibition Stadium (2-4) | 5-7 | |
| » W: Mike Flanagan (2-0) L: Les Straker (0-1) S: Tom Henke (2) | Fifth | 5½ out |
| Tuesday, April 19 |
| » Defeated Royals (6-7), 12-3 | Exhibition Stadium (3-4) | 6-7 | Won 2 |
| » W: Jim Clancy (1-2) L: Bret Saberhagen (1-2) | Fourth | 4½ out |
| Wednesday, April 20 |
| » Defeated Royals (6-8), 3-0 | Exhibition Stadium (4-4) | 7-7 | Won 3 |
| » W: Dave Stieb (1-2) L: Charlie Leibrandt (1-3) S: Tom Henke (3) | Fourth | 4½ out |
| Friday, April 22 |
| » Defeated Yankees (12-4), 6-4 | Yankee Stadium (1-0) | 8-7 | Won 4 |
| » W: David Wells (2-1) L: Tim Stoddard (1-1) S: Tom Henke (4) | Fifth | 4½ out |
| Saturday, April 23 |
| » Defeated Yankees (12-5), 3-2 | Yankee Stadium (2-0) | 9-7 | Won 5 |
| » W: John Cerutti (1-0) L: John Candelaria (1-2) S: Tom Henke (5) | Fifth | 4½ out |
| Sunday, April 24 |
| » Lost to Yankees (13-5), 5-3 | Yankee Stadium (2-1) | 9-8 | |
| » W: Charles Hudson (2-0) L: Mark Eichhorn (0-1) | Fifth | 4½ out |
| Tuesday, April 26 |
| » Lost to Athletics (13-7), 6-1 | Exhibition Stadium (4-5) | 9-9 | Lost 2 |
| » W: Storm Davis (2-1) L: Dave Stieb (1-3) S: Dennis Eckersley (9) | Fifth | 5½ out |
| Wednesday, April 27 |
| » Lost to Athletics (14-7), 5-3 | Exhibition Stadium (4-6) | 9-10 | Lost 3 |
| » W: Curt Young (1-0) L: Mike Flanagan (2-1) S: Rick Honeycutt (2) | Fifth | 6½ out |
| Thursday, April 28 |
| » Lost to Athletics (15-7), 6-2 | Exhibition Stadium (4-7) | 9-11 | Lost 4 |
| » W: Dave Stewart (6-0) L: Todd Stottlemyre (0-2) S: Rick Honeycutt (3) | Fifth | 6½ out |
| Friday, April 29 |
| » Lost to Angels (9-13), 9-5 | Exhibition Stadium (4-8) | 9-12 | Lost 5 |
| » W: Bryan Harvey (1-0) L: David Wells (2-2) | Fifth | 7 out |
| Saturday, April 30 |
| » Lost to Angels (10-13), 6-1 | Exhibition Stadium (4-9) | 9-13 | Lost 6 |
| » W: Chuck Finley (2-3) L: John Cerutti (1-1) | Sixth | 7 out |
| Sunday, May 1 |
| » Defeated Angels (10-14), 6-4 | Exhibition Stadium (5-9) | 10-13 | |
| » W: Dave Stieb (2-3) L: Mike Witt (1-3) S: Tom Henke (6) | Sixth | 6 out |
| Monday, May 2 |
| » Lost to Mariners (11-15), 7-5 | Kingdome (0-1) | 10-14 | |
| » W: Steve Trout (3-2) L: Mike Flanagan (2-2) S: Julio Solano (2) | Sixth | 7 out |
| Tuesday, May 3 |
| » Defeated Mariners (11-16), 9-2 | Kingdome (1-1) | 11-14 | |
| » W: Todd Stottlemyre (1-2) L: Mike Campbell (2-3) S: Duane Ward (2) | Sixth | 6½ out |
| Wednesday, May 4 |
| » Lost to Athletics (20-7), 3-2 | Oakland-Alameda County Stadium (0-1) | 11-15 | |
| » W: Bob Welch (4-2) L: Jim Clancy (1-3) S: Dennis Eckersley (11) | Sixth | 7½ out |
| Thursday, May 5 |
| » Lost to Athletics (21-7), 8-5 | Oakland-Alameda County Stadium (0-2) | 11-16 | Lost 2 |
| » W: Eric Plunk (3-1) L: Jose Nunez (0-1) | Sixth | 8½ out |
| Friday, May 6 |
| » Defeated Angels (11-18), 3-2 | Anaheim Stadium (1-0) | 12-16 | |
| » W: Dave Stieb (3-3) L: Mike Witt (1-4) S: Tom Henke (7) | Fourth | 7½ out |
| Saturday, May 7 |
| » Defeated Angels (11-19), 9-4 | Anaheim Stadium (2-0) | 13-16 | Won 2 |
| » W: Mike Flanagan (3-2) L: Willie Fraser (3-2) S: David Wells (1) | Fifth | 6½ out |
| Sunday, May 8 |
| » Lost to Angels (12-19), 8-1 | Anaheim Stadium (2-1) | 13-17 | |
| » W: Kirk McCaskill (2-3) L: Todd Stottlemyre (1-3) | Sixth | 6½ out |
| Tuesday, May 10 |
| » Lost to Mariners (15-18), 4-2 | Exhibition Stadium (5-10) | 13-18 | Lost 2 |
| » W: Mark Langston (3-3) L: Jim Clancy (1-4) | Sixth | 7½ out |
| Wednesday, May 11 |
| » Defeated Mariners (15-19), 9-3 | Exhibition Stadium (6-10) | 14-18 | |
| » W: Dave Stieb (4-3) L: Mike Moore (2-4) | Sixth | 7½ out |
| Thursday, May 12 |
| » Defeated Mariners (15-20), 8-2 | Exhibition Stadium (7-10) | 15-18 | Won 2 |
| » W: Mike Flanagan (4-2) L: Bill Swift (2-1) | Sixth | 7 out |
| Friday, May 13 |
| » Lost to White Sox (16-16), 4-1 | Comiskey Park I (0-1) | 15-19 | |
| » W: Melido Perez (3-0) L: Todd Stottlemyre (1-4) | Sixth | 7 out |
| Saturday, May 14 |
| » Lost to White Sox (17-16), 7-5 | Comiskey Park I (0-2) | 15-20 | Lost 2 |
| » W: Dave LaPoint (4-2) L: John Cerutti (1-2) S: Bill Long (2) | Sixth | 8 out |
| Sunday, May 15 |
| » Lost to White Sox (18-16), 6-5 | Comiskey Park I (0-3) | 15-21 | Lost 3 |
| » W: Bobby Thigpen (1-3) L: Mark Eichhorn (0-2) | Sixth | 9 out |
| Monday, May 16 |
| » Defeated White Sox (18-17), 5-1 | Comiskey Park I (1-3) | 16-21 | |
| » W: Dave Stieb (5-3) L: Ricky Horton (3-6) | Sixth | 9 out |
| Tuesday, May 17 |
| » Lost to Rangers (19-18), 7-6 | Exhibition Stadium (7-11) | 16-22 | |
| » W: Dale Mohorcic (2-0) L: Mark Eichhorn (0-3) | Sixth | 9 out |
| Wednesday, May 18 |
| » Lost to Rangers (20-18), 4-0 | Exhibition Stadium (7-12) | 16-23 | Lost 2 |
| » W: Ray Hayward (3-0) L: Todd Stottlemyre (1-5) | Sixth | 9½ out |
| Friday, May 20 |
| » Defeated Brewers (20-19), 3-1 | County Stadium (1-0) | 17-23 | |
| » W: Jim Clancy (2-4) L: Bill Wegman (4-5) S: David Wells (2) | Sixth | 8½ out |
| Saturday, May 21 |
| » Defeated Brewers (20-20), 4-0 | County Stadium (2-0) | 18-23 | Won 2 |
| » W: Dave Stieb (6-3) L: Chris Bosio (6-4) S: Tom Henke (8) | Sixth | 8½ out |
| Sunday, May 22 |
| » Lost to Brewers (21-20), 7-1 | County Stadium (2-1) | 18-24 | |
| » W: Mike Birkbeck (2-3) L: Mike Flanagan (4-3) | Sixth | 9½ out |
| Monday, May 23 |
| » Lost to Brewers (22-20), 9-7 | County Stadium (2-2) | 18-25 | Lost 2 |
| » W: Odell Jones (2-0) L: Todd Stottlemyre (1-6) S: Dan Plesac (9) | Sixth | 10½ out |
| Tuesday, May 24 |
| » Defeated Rangers (21-21), 13-2 | Arlington Stadium (1-0) | 19-25 | |
| » W: John Cerutti (2-2) L: Ray Hayward (3-1) S: Tom Henke (9) | Sixth | 10½ out |
| Wednesday, May 25 |
| » Lost to Rangers (22-21), 5-1 | Arlington Stadium (1-1) | 19-26 | |
| » W: Jeff Russell (3-0) L: Jim Clancy (2-5) S: Dale Mohorcic (4) | Sixth | 11½ out |
| Thursday, May 26 |
| » Lost to Rangers (23-21), 8-7 | Arlington Stadium (1-2) | 19-27 | Lost 2 |
| » W: Mitch Williams (1-1) L: Tom Henke (0-1) | Sixth | 12 out |
| Friday, May 27 |
| » Defeated White Sox (19-26), 4-3 | Exhibition Stadium (8-12) | 20-27 | |
| » W: Duane Ward (1-0) L: Bobby Thigpen (1-5) | Sixth | 12 out |
| Saturday, May 28 |
| » Lost to White Sox (20-26), 3-2 | Exhibition Stadium (8-13) | 20-28 | |
| » W: Melido Perez (5-1) L: Todd Stottlemyre (1-7) S: Bobby Thigpen (8) | Sixth | 12 out |
| Sunday, May 29 |
| » Defeated White Sox (20-27), 4-2 | Exhibition Stadium (9-13) | 21-28 | |
| » W: John Cerutti (3-2) L: Dave LaPoint (4-4) S: David Wells (3) | Sixth | 12 out |
| Monday, May 30 |
| » Lost to Brewers (26-23), 4-1 | Exhibition Stadium (9-14) | 21-29 | |
| » W: Teddy Higuera (4-3) L: Jim Clancy (2-6) S: Dan Plesac (11) | Sixth | 12 out |
| Tuesday, May 31 |
| » Defeated Brewers (26-24), 9-0 | Exhibition Stadium (10-14) | 22-29 | |
| » W: Dave Stieb (7-3) L: Chris Bosio (6-6) | Sixth | 12 out |
| Wednesday, June 1 |
| » Defeated Brewers (26-25), 7-2 | Exhibition Stadium (11-14) | 23-29 | Won 2 |
| » W: Mike Flanagan (5-3) L: Mike Birkbeck (2-5) S: Duane Ward (3) | Sixth | 11 out |
| Thursday, June 2 |
| » Defeated Red Sox (25-23), 5-4 | Fenway Park (1-0) | 24-29 | Won 3 |
| » W: David Wells (3-2) L: Bruce Hurst (6-3) S: Mark Eichhorn (1) | Sixth | 10½ out |
| Friday, June 3 |
| » Defeated Red Sox (25-24), 6-3 | Fenway Park (2-0) | 25-29 | Won 4 |
| » W: Todd Stottlemyre (2-7) L: Oil Can Boyd (5-4) S: Tom Henke (10) | Sixth | 10½ out |
| Saturday, June 4 |
| » Defeated Red Sox (25-25), 10-2 | Fenway Park (3-0) | 26-29 | Won 5 |
| » W: Jim Clancy (3-6) L: Roger Clemens (8-3) S: Duane Ward (4) | Sixth | 9½ out |
| Sunday, June 5 |
| » Defeated Red Sox (25-26), 12-4 | Fenway Park (4-0) | 27-29 | Won 6 |
| » W: Duane Ward (2-0) L: Mike Smithson (1-2) | Sixth | 9½ out |
| Monday, June 6 |
| » Lost to Indians (34-21), 6-3 | Cleveland Stadium (0-1) | 27-30 | |
| » W: John Farrell (6-3) L: Mike Flanagan (5-4) S: Doug Jones (13) | Sixth | 9½ out |
| Tuesday, June 7 |
| » Lost to Indians (35-21), 5-3 | Cleveland Stadium (0-2) | 27-31 | Lost 2 |
| » W: Scott Bailes (6-4) L: David Wells (3-3) | Sixth | 10½ out |
| Wednesday, June 8 |
| » Lost to Indians (36-21), 4-2 | Cleveland Stadium (0-3) | 27-32 | Lost 3 |
| » W: Rich Yett (5-3) L: Jim Clancy (3-7) S: Doug Jones (14) | Sixth | 10½ out |
| Friday, June 10 |
| » Defeated Red Sox (27-28), 3-0 | Exhibition Stadium (12-14) | 28-32 | |
| » W: Dave Stieb (8-3) L: Jeff Sellers (0-6) S: Tom Henke (11) | Sixth | 9½ out |
| Saturday, June 11 |
| » Defeated Red Sox (27-29), 4-3 | Exhibition Stadium (13-14) | 29-32 | Won 2 |
| » W: Duane Ward (3-0) L: Dennis Lamp (1-2) | Sixth | 9½ out |
| Sunday, June 12 |
| » Lost to Red Sox (28-29), 8-2 | Exhibition Stadium (13-15) | 29-33 | |
| » W: Oil Can Boyd (6-5) L: John Cerutti (3-3) | Sixth | 10½ out |
| Monday, June 13 |
| » Lost to Indians (37-25), 8-6 | Exhibition Stadium (13-16) | 29-34 | Lost 2 |
| » W: Bud Black (3-1) L: Jim Clancy (3-8) S: Doug Jones (15) | Sixth | 11½ out |
| Tuesday, June 14 |
| » Defeated Indians (37-26), 3-2 | Exhibition Stadium (14-16) | 30-34 | |
| » W: Duane Ward (4-0) L: Tom Candiotti (6-6) | Sixth | 10½ out |
| Wednesday, June 15 |
| » Defeated Indians (37-27), 15-3 | Exhibition Stadium (15-16) | 31-34 | Won 2 |
| » W: Dave Stieb (9-3) L: Greg Swindell (10-4) | Sixth | 9½ out |
| Thursday, June 16 |
| » Defeated Tigers (38-25), 13-5 | Tiger Stadium (1-0) | 32-34 | Won 3 |
| » W: Mike Flanagan (6-4) L: Jack Morris (6-8) | Sixth | 9 out |
| Friday, June 17 |
| » Lost to Tigers (39-25), 12-5 | Tiger Stadium (1-1) | 32-35 | |
| » W: Willie Hernandez (4-2) L: David Wells (3-4) | Sixth | 9 out |
| Saturday, June 18 |
| » Lost to Tigers (40-25), 6-1 | Tiger Stadium (1-2) | 32-36 | Lost 2 |
| » W: Walt Terrell (3-3) L: Jim Clancy (3-9) | Sixth | 10 out |
| Sunday, June 19 |
| » Defeated Tigers (40-26), 6-4 | Tiger Stadium (2-2) | 33-36 | |
| » W: Duane Ward (5-0) L: Mike Henneman (1-2) S: Tom Henke (12) | Sixth | 9 out |
| Monday, June 20 |
| » Defeated Orioles (18-50), 5-2 | Exhibition Stadium (16-16) | 34-36 | Won 2 |
| » W: Dave Stieb (10-3) L: Mike Boddicker (3-10) S: Tom Henke (13) | Sixth | 8½ out |
| Tuesday, June 21 |
| » Lost to Orioles (19-50), 4-2 | Exhibition Stadium (16-17) | 34-37 | |
| » W: Oswaldo Peraza (1-2) L: Mike Flanagan (6-5) S: Tom Niedenfuer (7) | Sixth | 9½ out |
| Wednesday, June 22 |
| » Defeated Orioles (19-51), 4-2 | Exhibition Stadium (17-17) | 35-37 | |
| » W: John Cerutti (4-3) L: Jeff Ballard (3-4) S: Duane Ward (5) | Sixth | 9½ out |
| Thursday, June 23 |
| » Defeated Orioles (19-52), 5-2 | Exhibition Stadium (18-17) | 36-37 | Won 2 |
| » W: Jim Clancy (4-9) L: Jay Tibbs (2-4) S: David Wells (4) | Sixth | 9 out |
| Friday, June 24 |
| » Defeated Tigers (43-27), 6-3 | Exhibition Stadium (19-17) | 37-37 | Won 3 |
| » W: Todd Stottlemyre (3-7) L: Walt Terrell (3-4) S: Tom Henke (14) | Sixth | 8 out |
| Saturday, June 25 |
| » Lost to Tigers (44-27), 7-2 | Exhibition Stadium (19-18) | 37-38 | |
| » W: Doyle Alexander (7-4) L: Dave Stieb (10-4) | Sixth | 9 out |
| Sunday, June 26 |
| » Defeated Tigers (44-28), 4-1 | Exhibition Stadium (20-18) | 38-38 | |
| » W: Mike Flanagan (7-5) L: Jeff Robinson (8-3) S: Tom Henke (15) | Sixth | 8 out |
| Monday, June 27 |
| » Lost to Orioles (21-54), 6-2 | Memorial Stadium (0-1) | 38-39 | |
| » W: Jeff Ballard (4-4) L: John Cerutti (4-4) | Fifth | 9 out |
| Tuesday, June 28 |
| » Lost to Orioles (22-54), 7-0 | Memorial Stadium (0-2) | 38-40 | Lost 2 |
| » W: Jay Tibbs (3-4) L: Jim Clancy (4-10) S: Mark Thurmond (1) | Sixth | 10 out |
| Wednesday, June 29 |
| » Defeated Orioles (22-55), 4-2 | Memorial Stadium (1-2) | 39-40 | |
| » W: Jimmy Key (3-1) L: Dave Schmidt (3-3) S: Tom Henke (16) | Sixth | 9 out |
| Friday, July 1 |
| » Lost to Athletics (49-29), 2-1 | Exhibition Stadium (20-19) | 39-41 | |
| » W: Dave Stewart (11-6) L: Dave Stieb (10-5) S: Dennis Eckersley (24) | Fifth | 10 out |
| Saturday, July 2 |
| » Lost to Athletics (50-29), 11-3 | Exhibition Stadium (20-20) | 39-42 | Lost 2 |
| » W: Curt Young (6-5) L: Mike Flanagan (7-6) S: Gene Nelson (3) | Sixth | 11 out |
| Sunday, July 3 |
| » Lost to Athletics (51-29), 9-8 | Exhibition Stadium (20-21) | 39-43 | Lost 3 |
| » W: Todd Burns (1-0) L: John Cerutti (4-5) | Sixth | 11 out |
| Monday, July 4 |
| » Lost to Angels (36-45), 11-6 | Exhibition Stadium (20-22) | 39-44 | Lost 4 |
| » W: Stew Cliburn (3-0) L: Jim Clancy (4-11) | Sixth | 12 out |
| Tuesday, July 5 |
| » Defeated Angels (36-46), 4-1 | Exhibition Stadium (21-22) | 40-44 | |
| » W: Jimmy Key (4-1) L: Mike Witt (6-9) S: Duane Ward (6) | Sixth | 11 out |
| Wednesday, July 6 |
| » Lost to Angels (37-46), 5-4 | Exhibition Stadium (21-23) | 40-45 | |
| » W: Bryan Harvey (3-2) L: David Wells (3-5) S: Donnie Moore (2) | Sixth | 12 out |
| Friday, July 8 |
| » Defeated Mariners (33-52), 3-2 | Exhibition Stadium (22-23) | 41-45 | |
| » W: Mike Flanagan (8-6) L: Bill Swift (6-6) S: Duane Ward (7) | Sixth | 11½ out |
| Saturday, July 9 |
| » Lost to Mariners (34-52), 9-3 | Exhibition Stadium (22-24) | 41-46 | |
| » W: Scott Bankhead (4-3) L: Todd Stottlemyre (3-8) | Sixth | 12½ out |
| Sunday, July 10 |
| » Defeated Mariners (34-53), 5-0 | Exhibition Stadium (23-24) | 42-46 | |
| » W: Jimmy Key (5-1) L: Mike Moore (4-9) | Sixth | 11½ out |
| Thursday, July 14 |
| » Defeated Athletics (54-35), 7-1 | Oakland-Alameda County Stadium (1-2) | 43-46 | Won 2 |
| » W: Mike Flanagan (9-6) L: Bob Welch (10-6) | Sixth | 10½ out |
| Friday, July 15 |
| » Defeated Athletics (54-36), 1-0 | Oakland-Alameda County Stadium (2-2) | 44-46 | Won 3 |
| » W: Jimmy Key (6-1) L: Dave Stewart (12-8) | Sixth | 9½ out |
| Saturday, July 16 |
| » Lost to Athletics (55-36), 4-1 | Oakland-Alameda County Stadium (2-3) | 44-47 | |
| » W: Storm Davis (7-4) L: Dave Stieb (10-6) S: Dennis Eckersley (27) | Sixth | 10½ out |
| Sunday, July 17 |
| » Defeated Athletics (55-37), 9-6 | Oakland-Alameda County Stadium (3-3) | 45-47 | |
| » W: Duane Ward (6-0) L: Curt Young (6-7) S: Tom Henke (17) | Sixth | 9½ out |
| Monday, July 18 |
| » Defeated Angels (44-48), 12-2 | Anaheim Stadium (3-1) | 46-47 | Won 2 |
| » W: Jeff Musselman (1-0) L: Chuck Finley (5-9) S: Jim Clancy (1) | Sixth | 9½ out |
| Tuesday, July 19 |
| » Defeated Angels (44-49), 7-6 | Anaheim Stadium (4-1) | 47-47 | Won 3 |
| » W: Tom Henke (1-1) L: Bryan Harvey (4-3) | Fifth | 8½ out |
| Wednesday, July 20 |
| » Lost to Angels (45-49), 7-6 | Anaheim Stadium (4-2) | 47-48 | |
| » W: Greg Minton (3-1) L: John Cerutti (4-6) S: Donnie Moore (4) | Sixth | 9½ out |
| Thursday, July 21 |
| » Lost to Mariners (38-57), 6-2 | Kingdome (1-2) | 47-49 | Lost 2 |
| » W: Scott Bankhead (5-4) L: Dave Stieb (10-7) S: Mike Schooler (7) | Sixth | 10 out |
| Friday, July 22 |
| » Lost to Mariners (39-57), 10-9 | Kingdome (1-3) | 47-50 | Lost 3 |
| » W: Mike Schooler (2-3) L: Tom Henke (1-2) | Sixth | 10 out |
| Saturday, July 23 |
| » Defeated Mariners (39-58), 5-2 | Kingdome (2-3) | 48-50 | |
| » W: Jeff Musselman (2-0) L: Steve Trout (4-6) | Fifth | 9 out |
| Sunday, July 24 |
| » Defeated Mariners (39-59), 6-0 | Kingdome (3-3) | 49-50 | Won 2 |
| » W: Mike Flanagan (10-6) L: Mark Langston (7-9) | Fourth | 8 out |
| Monday, July 25 |
| » Lost to Twins (54-43), 5-4 | Hubert H. Humphrey Metrodome (1-3) | 49-51 | |
| » W: Jim Winn (1-0) L: Tom Henke (1-3) | Sixth | 9 out |
| Tuesday, July 26 |
| » Lost to Twins (55-43), 6-3 | Hubert H. Humphrey Metrodome (1-4) | 49-52 | Lost 2 |
| » W: Mark Portugal (1-1) L: Duane Ward (6-1) S: Jeff Reardon (26) | Sixth | 10 out |
| Wednesday, July 27 |
| » Defeated Twins (55-44), 4-1 | Hubert H. Humphrey Metrodome (2-4) | 50-52 | |
| » W: John Cerutti (5-6) L: Frank Viola (16-3) S: Tom Henke (18) | Fifth | 10 out |
| Friday, July 29 |
| » Defeated Yankees (58-42), 7-1 | Exhibition Stadium (24-24) | 51-52 | Won 2 |
| » W: Jeff Musselman (3-0) L: Richard Dotson (8-4) | Sixth | 9½ out |
| » Major-league debuts: Hal Morris (Yankees) |
| Saturday, July 30 |
| » Lost to Yankees (59-42), 3-1 | Exhibition Stadium (24-25) | 51-53 | |
| » W: John Candelaria (12-6) L: Mike Flanagan (10-7) S: Dave Righetti (15) | Sixth | 10½ out |
| Sunday, July 31 |
| » Lost to Yankees (60-42), 6-3 | Exhibition Stadium (24-26) | 51-54 | Lost 2 |
| » W: Rick Rhoden (7-6) L: Jimmy Key (6-2) S: Dave Righetti (16) | Sixth | 11½ out |
| Monday, August 1 |
| » Defeated Twins (57-46), 3-1 | Exhibition Stadium (25-26) | 52-54 | |
| » W: Dave Stieb (11-7) L: Frank Viola (16-4) S: Tom Henke (19) | Fifth | 10½ out |
| Tuesday, August 2 |
| » Defeated Twins (57-47), 11-1 | Exhibition Stadium (26-26) | 53-54 | Won 2 |
| » W: Jim Clancy (5-11) L: Charlie Lea (6-5) | Fourth | 10½ out |
| Wednesday, August 3 |
| » Lost to Twins (58-47), 8-3 | Exhibition Stadium (26-27) | 53-55 | |
| » W: Keith Atherton (6-5) L: Jeff Musselman (3-1) S: Jeff Reardon (27) | Fourth | 10½ out |
| Thursday, August 4 |
| » Lost to Twins (59-47), 2-1 | Exhibition Stadium (26-28) | 53-56 | Lost 2 |
| » W: Allan Anderson (9-7) L: Mike Flanagan (10-8) | Fifth | 11½ out |
| Friday, August 5 |
| » Defeated Royals (54-54), 7-6 | Exhibition Stadium (27-28) | 54-56 | |
| » W: Duane Ward (7-1) L: Ted Power (5-5) S: Tom Henke (20) | Fifth | 12 out |
| Saturday, August 6 |
| » Lost to Royals (55-54), 11-1 | Exhibition Stadium (27-29) | 54-57 | |
| » W: Mark Gubicza (14-6) L: Dave Stieb (11-8) | Fifth | 13 out |
| Sunday, August 7 |
| » Lost to Royals (56-54), 5-1 | Exhibition Stadium (27-30) | 54-58 | Lost 2 |
| » W: Floyd Bannister (9-9) L: Jim Clancy (5-12) | Fifth | 13 out |
| Monday, August 8 |
| » Defeated Royals (56-55), 5-1 | Exhibition Stadium (28-30) | 55-58 | |
| » W: Jeff Musselman (4-1) L: Bret Saberhagen (12-11) S: Tom Henke (21) | Fifth | 13 out |
| Tuesday, August 9 |
| » Defeated Yankees (62-47), 6-3 | Yankee Stadium (3-1) | 56-58 | Won 2 |
| » W: Mike Flanagan (11-8) L: John Candelaria (12-7) S: Duane Ward (8) | Fifth | 12 out |
| Wednesday, August 10 |
| » Defeated Yankees (62-48), 5-0 | Yankee Stadium (4-1) | 57-58 | Won 3 |
| » W: Jimmy Key (7-2) L: Rick Rhoden (7-8) S: Tom Henke (22) | Fifth | 12 out |
| Thursday, August 11 |
| » Defeated Yankees (62-49), 6-5 | Yankee Stadium (5-1) | 58-58 | Won 4 |
| » W: Duane Ward (8-1) L: Dave Righetti (3-3) | Fifth | 11½ out |
| Friday, August 12 |
| » Defeated Royals (59-56), 3-2 | Royals Stadium (3-1) | 59-58 | Won 5 |
| » W: Jim Clancy (6-12) L: Floyd Bannister (9-10) S: Tom Henke (23) | Fifth | 10½ out |
| Saturday, August 13 |
| » Defeated Royals (59-57), 2-0 | Royals Stadium (4-1) | 60-58 | Won 6 |
| » W: Jeff Musselman (5-1) L: Bret Saberhagen (12-12) S: Duane Ward (9) | Fourth | 9½ out |
| Sunday, August 14 |
| » Lost to Royals (60-57), 6-0 | Royals Stadium (4-2) | 60-59 | |
| » W: Luis Aquino (1-0) L: Mike Flanagan (11-9) | Fourth | 10½ out |
| » Major-league debuts: Tony Castillo (Blue Jays) |
| Tuesday, August 16 |
| » Lost to White Sox (53-66), 5-4 | Comiskey Park I (1-4) | 60-60 | Lost 2 |
| » W: Jack McDowell (5-8) L: Jimmy Key (7-3) S: Bobby Thigpen (26) | Fifth | 10 out |
| Wednesday, August 17 |
| » Lost to White Sox (54-66), 5-1 | Comiskey Park I (1-5) | 60-61 | Lost 3 |
| » W: Jerry Reuss (9-7) L: Jim Clancy (6-13) S: Steve Rosenberg (1) | Fifth | 10 out |
| Friday, August 19 |
| » Lost to Brewers (62-62), 7-4 | Exhibition Stadium (28-31) | 60-62 | Lost 4 |
| » W: Juan Nieves (5-5) L: Duane Ward (8-2) S: Dan Plesac (29) | Fifth | 11½ out |
| Saturday, August 20 |
| » Lost to Brewers (63-62), 8-1 | Exhibition Stadium (28-32) | 60-63 | Lost 5 |
| » W: Teddy Higuera (10-8) L: Mike Flanagan (11-10) | Fifth | 12½ out |
| Sunday, August 21 |
| » Defeated Brewers (63-63), 8-4 | Exhibition Stadium (29-32) | 61-63 | |
| » W: Jimmy Key (8-3) L: Don August (7-6) | Fifth | 12½ out |
| Monday, August 22 |
| » Defeated White Sox (54-71), 6-3 | Exhibition Stadium (30-32) | 62-63 | Won 2 |
| » W: Dave Stieb (12-8) L: Jerry Reuss (9-8) | Fifth | 11½ out |
| Tuesday, August 23 |
| » Defeated White Sox (54-72), 7-2 | Exhibition Stadium (31-32) | 63-63 | Won 3 |
| » W: Jim Clancy (7-13) L: Melido Perez (11-8) S: Duane Ward (10) | Fourth | 10½ out |
| Wednesday, August 24 |
| » Lost to White Sox (55-72), 6-4 | Exhibition Stadium (31-33) | 63-64 | |
| » W: Bill Long (5-9) L: Jeff Musselman (5-2) S: Bobby Thigpen (27) | Fourth | 10½ out |
| Friday, August 26 |
| » Lost to Rangers (58-68), 5-1 | Arlington Stadium (1-3) | 63-65 | Lost 2 |
| » W: Paul Kilgus (11-11) L: Mike Flanagan (11-11) S: Mitch Williams (17) | Fifth | 11½ out |
| Saturday, August 27 |
| » Lost to Rangers (59-68), 5-3 | Arlington Stadium (1-4) | 63-66 | Lost 3 |
| » W: Charlie Hough (11-14) L: Jimmy Key (8-4) S: Mitch Williams (18) | Fifth | 11½ out |
| Sunday, August 28 |
| » Defeated Rangers (59-69), 6-5 | Arlington Stadium (2-4) | 64-66 | |
| » W: Tom Henke (2-3) L: Craig McMurtry (2-2) | Fifth | 10½ out |
| Monday, August 29 |
| » Defeated Brewers (67-67), 6-1 | County Stadium (3-2) | 65-66 | Won 2 |
| » W: Jim Clancy (8-13) L: Tom Filer (5-8) | Fifth | 9½ out |
| Tuesday, August 30 |
| » Lost to Brewers (68-67), 6-2 | County Stadium (3-3) | 65-67 | |
| » W: Teddy Higuera (12-8) L: Jeff Musselman (5-3) | Fifth | 9½ out |
| Wednesday, August 31 |
| » Lost to Brewers (69-67), 4-2 | County Stadium (3-4) | 65-68 | Lost 2 |
| » W: Don August (8-6) L: Mike Flanagan (11-12) S: Chuck Crim (8) | Fifth | 10½ out |
| Thursday, September 1 |
| » Defeated Rangers (60-72), 5-1 | Exhibition Stadium (32-33) | 66-68 | |
| » W: Jimmy Key (9-4) L: Charlie Hough (11-15) | Fifth | 9½ out |
| Friday, September 2 |
| » Defeated Rangers (60-73), 7-6 | Exhibition Stadium (33-33) | 67-68 | Won 2 |
| » W: Tom Henke (3-3) L: Ed Vande Berg (1-2) | Fifth | 8½ out |
| Saturday, September 3 |
| » Defeated Rangers (60-74), 7-4 | Exhibition Stadium (34-33) | 68-68 | Won 3 |
| » W: Tony Castillo (1-0) L: Jeff Russell (10-7) S: Duane Ward (11) | Fifth | 7½ out |
| Sunday, September 4 |
| » Defeated Rangers (60-75), 9-7 | Exhibition Stadium (35-33) | 69-68 | Won 4 |
| » W: John Cerutti (6-6) L: Mitch Williams (2-5) | Fourth | 6½ out |
| Monday, September 5 |
| » Defeated Tigers (75-62), 5-4 | Tiger Stadium (3-2) | 70-68 | Won 5 |
| » W: Todd Stottlemyre (4-8) L: Willie Hernandez (5-4) S: Duane Ward (12) | Fifth | 6½ out |
| Tuesday, September 6 |
| » Defeated Tigers (75-63), 7-3 | Tiger Stadium (4-2) | 71-68 | Won 6 |
| » W: Jimmy Key (10-4) L: Doyle Alexander (11-11) S: Duane Ward (13) | Fifth | 6½ out |
| Wednesday, September 7 |
| » Lost to Tigers (76-63), 4-3 | Tiger Stadium (4-3) | 71-69 | |
| » W: Mike Henneman (8-4) L: John Cerutti (6-7) | Fifth | 6½ out |
| Thursday, September 8 |
| » Major-league debuts: Tom Gordon Mark Lee and Rey Palacios (Royals) |
| Friday, September 9 |
| » Defeated Orioles (49-90), 8-1 | Memorial Stadium (2-2) | 72-69 | |
| » W: Jim Clancy (9-13) L: Jose Bautista (6-13) | Fifth | 6½ out |
| Saturday, September 10 |
| » Lost to Orioles (50-90), 7-4 | Memorial Stadium (2-3) | 72-70 | |
| » W: Jeff Ballard (8-11) L: Jeff Musselman (5-4) S: Mark Williamson (2) | Fifth | 7½ out |
| Sunday, September 11 |
| » Lost to Orioles (51-90), 4-2 | Memorial Stadium (2-4) | 72-71 | Lost 2 |
| » W: Dave Schmidt (8-4) L: Mike Flanagan (11-13) S: Mark Thurmond (3) | Fifth | 7½ out |
| Monday, September 12 |
| » Lost to Tigers (77-67), 6-5 | Exhibition Stadium (35-34) | 72-72 | Lost 3 |
| » W: Mark Huismann (1-0) L: Tom Henke (3-4) S: Willie Hernandez (9) | Fifth | 8½ out |
| Tuesday, September 13 |
| » Defeated Tigers (77-68), 9-1 | Exhibition Stadium (36-34) | 73-72 | |
| » W: Dave Stieb (13-8) L: Ted Power (5-7) | Fifth | 8½ out |
| Wednesday, September 14 |
| » Defeated Tigers (77-69), 3-2 | Exhibition Stadium (37-34) | 74-72 | Won 2 |
| » W: Duane Ward (9-2) L: Walt Terrell (7-14) | Fifth | 8½ out |
| Thursday, September 15 |
| » Defeated Indians (70-76), 3-0 | Exhibition Stadium (38-34) | 75-72 | Won 3 |
| » W: Jeff Musselman (6-4) L: Mike Walker (0-1) S: Tom Henke (24) | Fifth | 7½ out |
| Friday, September 16 |
| » Defeated Indians (70-77), 4-3 | Exhibition Stadium (39-34) | 76-72 | Won 4 |
| » W: Tom Henke (4-4) L: Don Gordon (2-4) | Fifth | 7½ out |
| Saturday, September 17 |
| » Lost to Indians (71-77), 12-3 | Exhibition Stadium (39-35) | 76-73 | |
| » W: Greg Swindell (17-13) L: Jimmy Key (10-5) S: Jeff Dedmon (1) | Fifth | 8½ out |
| Sunday, September 18 |
| » Defeated Indians (71-78), 4-0 | Exhibition Stadium (40-35) | 77-73 | |
| » W: Dave Stieb (14-8) L: Rod Nichols (1-5) | Fifth | 8½ out |
| Monday, September 19 |
| » Defeated Red Sox (85-65), 5-4 | Exhibition Stadium (41-35) | 78-73 | Won 2 |
| » W: Jim Clancy (10-13) L: Dennis Lamp (6-5) S: Duane Ward (14) | Fifth | 7½ out |
| Tuesday, September 20 |
| » Lost to Red Sox (86-65), 13-2 | Exhibition Stadium (41-36) | 78-74 | |
| » W: Roger Clemens (17-11) L: Jeff Musselman (6-5) | Fifth | 8½ out |
| Wednesday, September 21 |
| » Defeated Red Sox (86-66), 1-0 | Exhibition Stadium (42-36) | 79-74 | |
| » W: Mike Flanagan (12-13) L: Wes Gardner (8-5) S: Duane Ward (15) | Fifth | 7½ out |