| Tuesday, April 5 |
| » Defeated Padres (0-1), 6-3 | Astrodome (1-0) | 1-0 | |
| » W: Mike Scott (1-0) L: Lance McCullers (0-1) S: Dave Smith (1) | First | -- |
| Wednesday, April 6 |
| » Defeated Padres (0-2), 5-1 | Astrodome (2-0) | 2-0 | Won 2 |
| » W: Bob Knepper (1-0) L: Andy Hawkins (0-1) | First | -- |
| » Major-league debuts: Candy Sierra (Padres) |
| Friday, April 8 |
| » Defeated Reds (2-1), 8-3 | Riverfront Stadium (1-0) | 3-0 | Won 3 |
| » W: Larry Andersen (1-0) L: Jose Rijo (0-1) | First | -- |
| Saturday, April 9 |
| » Lost to Reds (3-1), 5-4 | Riverfront Stadium (1-1) | 3-1 | |
| » W: Jose Rijo (1-1) L: Dave Smith (0-1) | Second | ½ out |
| Sunday, April 10 |
| » Defeated Reds (3-2), 12-3 | Riverfront Stadium (2-1) | 4-1 | |
| » W: Mike Scott (2-0) L: Ron Robinson (0-1) | Second | ½ out |
| Tuesday, April 12 |
| » Defeated Braves (0-7), 8-3 | Atlanta-Fulton County Stadium (1-0) | 5-1 | Won 2 |
| » W: Nolan Ryan (1-0) L: Zane Smith (0-2) | First | -- |
| Wednesday, April 13 |
| » Defeated Braves (0-8), 4-0 | Atlanta-Fulton County Stadium (2-0) | 6-1 | Won 3 |
| » W: Jim Deshaies (1-0) L: Pete Smith (0-1) | First | -- |
| Thursday, April 14 |
| » Defeated Reds (5-4), 9-3 | Astrodome (3-0) | 7-1 | Won 4 |
| » W: Danny Darwin (1-0) L: Dennis Rasmussen (0-1) | First | -- |
| Friday, April 15 |
| » Lost to Reds (6-4), 4-2 | Astrodome (3-1) | 7-2 | |
| » W: Jose Rijo (2-1) L: Larry Andersen (1-1) S: John Franco (2) | First | -- |
| Saturday, April 16 |
| » Lost to Reds (7-4), 8-2 | Astrodome (3-2) | 7-3 | Lost 2 |
| » W: Jose Rijo (3-1) L: Ernie Camacho (0-1) | Second | ½ out |
| Sunday, April 17 |
| » Defeated Reds (7-5), 5-3 | Astrodome (4-2) | 8-3 | |
| » W: Nolan Ryan (2-0) L: Danny Jackson (2-1) S: Dave Smith (2) | First | -- |
| Tuesday, April 19 |
| » Lost to Braves (2-10), 5-4 | Astrodome (4-3) | 8-4 | |
| » W: Bruce Sutter (1-0) L: Jim Deshaies (1-1) S: Paul Assenmacher (1) | Second | ½ out |
| Wednesday, April 20 |
| » Defeated Braves (2-11), 1-0 | Astrodome (5-3) | 9-4 | |
| » W: Mike Scott (3-0) L: Tom Glavine (0-3) | First | -- |
| Thursday, April 21 |
| » Defeated Braves (2-12), 8-0 | Astrodome (6-3) | 10-4 | Won 2 |
| » W: Bob Knepper (2-0) L: Kevin Coffman (0-2) S: Ernie Camacho (1) | First | -- |
| Friday, April 22 |
| » Lost to Padres (5-9), 3-1 | San Diego/Jack Murphy Stadium (0-1) | 10-5 | |
| » W: Jimmy Jones (2-1) L: Nolan Ryan (2-1) S: Mark Davis (2) | Second | 1 out |
| » Major-league debuts: Roberto Alomar (Padres) |
| Saturday, April 23 |
| » Lost to Padres (6-9), 4-0 | San Diego/Jack Murphy Stadium (0-2) | 10-6 | Lost 2 |
| » W: Ed Whitson (2-0) L: Danny Darwin (1-1) | Second | 1 out |
| Sunday, April 24 |
| » Lost to Padres (7-9), 3-0 | San Diego/Jack Murphy Stadium (0-3) | 10-7 | Lost 3 |
| » W: Andy Hawkins (2-1) L: Jim Deshaies (1-2) | Second | 2 out |
| Tuesday, April 26 |
| » Defeated Phillies (6-11), 3-1 | Astrodome (7-3) | 11-7 | |
| » W: Mike Scott (4-0) L: Shane Rawley (0-4) S: Dave Smith (3) | Second | 1 out |
| Wednesday, April 27 |
| » Defeated Phillies (6-12), 3-2 | Astrodome (8-3) | 12-7 | Won 2 |
| » W: Dave Smith (1-1) L: Kent Tekulve (0-2) | Second | 1 out |
| Friday, April 29 |
| » Defeated Expos (9-10), 6-4 | Astrodome (9-3) | 13-7 | Won 3 |
| » W: Juan Agosto (1-0) L: Tim Burke (1-1) S: Dave Smith (4) | Second | ½ out |
| Saturday, April 30 |
| » Defeated Expos (9-11), 3-0 | Astrodome (10-3) | 14-7 | Won 4 |
| » W: Jim Deshaies (2-2) L: Bryn Smith (0-2) S: Dave Smith (5) | First | -- |
| Sunday, May 1 |
| » Lost to Expos (10-11), 7-3 | Astrodome (10-4) | 14-8 | |
| » W: Jeff Parrett (2-0) L: Jeff Heathcock (0-1) | First | -- |
| Monday, May 2 |
| » Lost to Phillies (8-13), 7-1 | Veteran's Stadium (0-1) | 14-9 | Lost 2 |
| » W: Kevin Gross (2-1) L: Nolan Ryan (2-2) | Second | ½ out |
| Tuesday, May 3 |
| » Defeated Phillies (8-14), 4-0 | Veteran's Stadium (1-1) | 15-9 | |
| » W: Bob Knepper (3-0) L: Bruce Ruffin (2-2) | Second | ½ out |
| Wednesday, May 4 |
| » Lost to Mets (18-7), 8-0 | Shea Stadium (0-1) | 15-10 | |
| » W: Sid Fernandez (1-1) L: Danny Darwin (1-2) S: Terry Leach (1) | Second | 1½ out |
| Friday, May 6 |
| » Lost to Expos (13-13), 6-5 | Stade Olympique (0-1) | 15-11 | Lost 2 |
| » W: Bob McClure (1-1) L: Ernie Camacho (0-2) | Second | 2½ out |
| Saturday, May 7 |
| » Lost to Expos (14-13), 4-3 | Stade Olympique (0-2) | 15-12 | Lost 3 |
| » W: Jeff Parrett (3-0) L: Jeff Heathcock (0-2) | Second | 2½ out |
| Sunday, May 8 |
| » Defeated Expos (14-14), 7-2 | Stade Olympique (1-2) | 16-12 | |
| » W: Bob Knepper (4-0) L: Floyd Youmans (0-3) | Second | 2½ out |
| Monday, May 9 |
| » Defeated Mets (21-8), 6-2 | Astrodome (11-4) | 17-12 | Won 2 |
| » W: Danny Darwin (2-2) L: Sid Fernandez (1-2) | Second | 2 out |
| Tuesday, May 10 |
| » Lost to Mets (22-8), 5-2 | Astrodome (11-5) | 17-13 | |
| » W: David Cone (4-0) L: Ernie Camacho (0-3) S: Roger McDowell (3) | Second | 3 out |
| Wednesday, May 11 |
| » Lost to Mets (23-8), 9-8 | Astrodome (11-6) | 17-14 | Lost 2 |
| » W: Terry Leach (1-0) L: Dave Smith (1-2) | Second | 3 out |
| Friday, May 13 |
| » Defeated Cubs (17-16), 8-2 | Astrodome (12-6) | 18-14 | |
| » W: Nolan Ryan (3-2) L: Jamie Moyer (2-4) | Second | 1½ out |
| Saturday, May 14 |
| » Defeated Cubs (17-17), 3-1 | Astrodome (13-6) | 19-14 | Won 2 |
| » W: Bob Knepper (5-0) L: Al Nipper (0-1) S: Dave Smith (6) | Second | 1½ out |
| Sunday, May 15 |
| » Lost to Cubs (18-17), 2-1 | Astrodome (13-7) | 19-15 | |
| » W: Rick Sutcliffe (3-3) L: Danny Darwin (2-3) | Second | 2½ out |
| Monday, May 16 |
| » Defeated Pirates (23-14), 9-2 | Astrodome (14-7) | 20-15 | |
| » W: Jim Deshaies (3-2) L: Bob Walk (4-2) | Second | 2 out |
| Tuesday, May 17 |
| » Defeated Pirates (23-15), 3-2 | Astrodome (15-7) | 21-15 | Won 2 |
| » W: Mike Scott (5-0) L: John Smiley (3-3) S: Dave Smith (7) | Second | 1 out |
| Wednesday, May 18 |
| » Defeated Pirates (23-16), 4-2 | Astrodome (16-7) | 22-15 | Won 3 |
| » W: Nolan Ryan (4-2) L: Doug Drabek (4-3) S: Dave Smith (8) | Second | 1 out |
| Friday, May 20 |
| » Defeated Cardinals (20-20), 5-3 | Busch Stadium II (1-0) | 23-15 | Won 4 |
| » W: Bob Knepper (6-0) L: Scott Terry (2-2) S: Dave Smith (9) | First | -- |
| Saturday, May 21 |
| » Lost to Cardinals (21-20), 7-4 | Busch Stadium II (1-1) | 23-16 | |
| » W: Bob Forsch (4-3) L: Joaquin Andujar (0-1) | First | -- |
| Sunday, May 22 |
| » Defeated Cardinals (21-21), 2-1 | Busch Stadium II (2-1) | 24-16 | |
| » W: Juan Agosto (2-0) L: Ken Dayley (0-1) S: Larry Andersen (1) | First | -- |
| Monday, May 23 |
| » Defeated Pirates (25-18), 3-0 | Three Rivers Stadium (1-0) | 25-16 | Won 2 |
| » W: Mike Scott (6-0) L: John Smiley (3-4) | First | -- |
| Tuesday, May 24 |
| » Lost to Pirates (26-18), 5-4 | Three Rivers Stadium (1-1) | 25-17 | |
| » W: Jim Gott (2-1) L: Larry Andersen (1-2) | First | -- |
| Wednesday, May 25 |
| » Lost to Pirates (27-18), 4-3 | Three Rivers Stadium (1-2) | 25-18 | Lost 2 |
| » W: Mike Dunne (3-2) L: Joaquin Andujar (0-2) S: Jeff Robinson (5) | Second | 1 out |
| Friday, May 27 |
| » Lost to Cubs (22-23), 3-2 | Wrigley Field (0-1) | 25-19 | Lost 3 |
| » W: Greg Maddux (8-3) L: Danny Darwin (2-4) S: Rich Gossage (6) | Second | 1½ out |
| Saturday, May 28 |
| » Lost to Cubs (23-23), 14-7 | Wrigley Field (0-2) | 25-20 | Lost 4 |
| » W: Calvin Schiraldi (3-2) L: Mike Scott (6-1) S: Frank DiPino (3) | Second | 1½ out |
| Sunday, May 29 |
| » Defeated Cubs (23-24), 7-1 | Wrigley Field (1-2) | 26-20 | |
| » W: Nolan Ryan (5-2) L: Jamie Moyer (2-6) | Second | 1½ out |
| Monday, May 30 |
| » Defeated Cardinals (25-24), 5-4 | Astrodome (17-7) | 27-20 | Won 2 |
| » W: Jim Deshaies (4-2) L: Scott Terry (2-3) S: Dave Smith (10) | Second | ½ out |
| Tuesday, May 31 |
| » Lost to Cardinals (26-24), 9-7 | Astrodome (17-8) | 27-21 | |
| » W: Larry McWilliams (4-0) L: Bob Knepper (6-1) S: Todd Worrell (14) | Second | ½ out |
| Wednesday, June 1 |
| » Lost to Cardinals (27-24), 3-2 | Astrodome (17-9) | 27-22 | Lost 2 |
| » W: Steve Peters (2-2) L: Jeff Heathcock (0-3) S: Todd Worrell (15) | Second | 1½ out |
| Friday, June 3 |
| » Defeated Giants (26-27), 8-4 | Candlestick Park (1-0) | 28-22 | |
| » W: Dave Smith (2-2) L: Scott Garrelts (1-4) | Second | 1½ out |
| Saturday, June 4 |
| » Lost to Giants (27-27), 8-2 | Candlestick Park (1-1) | 28-23 | |
| » W: Mike LaCoss (4-4) L: Nolan Ryan (5-3) S: Joe Price (3) | Second | 1½ out |
| Sunday, June 5 |
| » Lost to Giants (28-27), 9-3 | Candlestick Park (1-2) | 28-24 | Lost 2 |
| » W: Rick Reuschel (8-3) L: Jim Deshaies (4-3) S: Craig Lefferts (5) | Second | 2½ out |
| Monday, June 6 |
| » Defeated Dodgers (30-22), 10-4 | Dodger Stadium (1-0) | 29-24 | |
| » W: Bob Knepper (7-1) L: Alejandro Pena (2-3) S: Larry Andersen (2) | Second | 1½ out |
| Tuesday, June 7 |
| » Defeated Dodgers (30-23), 5-2 | Dodger Stadium (2-0) | 30-24 | Won 2 |
| » W: Danny Darwin (3-4) L: Tim Belcher (3-3) | Second | ½ out |
| Wednesday, June 8 |
| » Lost to Dodgers (31-23), 11-1 | Dodger Stadium (2-1) | 30-25 | |
| » W: Fernando Valenzuela (4-5) L: Mike Scott (6-2) | Second | 1½ out |
| Thursday, June 9 |
| » Lost to Dodgers (32-23), 4-2 | Dodger Stadium (2-2) | 30-26 | Lost 2 |
| » W: Orel Hershiser (8-3) L: Nolan Ryan (5-4) S: Jay Howell (6) | Second | 2½ out |
| Friday, June 10 |
| » Lost to Braves (20-35), 10-3 | Astrodome (17-10) | 30-27 | Lost 3 |
| » W: Juan Eichelberger (1-0) L: Dave Smith (2-3) | Second | 2½ out |
| Saturday, June 11 |
| » Defeated Braves (20-36), 5-4 | Astrodome (18-10) | 31-27 | |
| » W: Dave Smith (3-3) L: Charlie Puleo (0-3) | Second | 1½ out |
| Sunday, June 12 |
| » Defeated Braves (20-37), 5-0 | Astrodome (19-10) | 32-27 | Won 2 |
| » W: Mike Scott (7-2) L: Rick Mahler (7-6) | Second | ½ out |
| Monday, June 13 |
| » Defeated Braves (20-38), 6-5 | Astrodome (20-10) | 33-27 | Won 3 |
| » W: Juan Agosto (3-0) L: Jose Alvarez (2-2) S: Dave Smith (11) | Second | 1 out |
| Tuesday, June 14 |
| » Lost to Reds (29-33), 7-1 | Riverfront Stadium (2-2) | 33-28 | |
| » W: Jose Rijo (8-1) L: Danny Darwin (3-5) | Second | 1 out |
| Wednesday, June 15 |
| » Lost to Reds (30-33), 5-3 | Riverfront Stadium (2-3) | 33-29 | Lost 2 |
| » W: Tom Browning (5-3) L: Jim Deshaies (4-4) S: John Franco (7) | Second | 2 out |
| Thursday, June 16 |
| » Defeated Reds (30-34), 7-4 | Riverfront Stadium (3-3) | 34-29 | |
| » W: Mike Scott (8-2) L: Mario Soto (3-7) S: Dave Smith (12) | Second | 1 out |
| Friday, June 17 |
| » Lost to Braves (22-40), 4-3 | Atlanta-Fulton County Stadium (2-1) | 34-30 | |
| » W: Paul Assenmacher (2-3) L: Larry Andersen (1-3) S: Bruce Sutter (10) | Second | 1 out |
| » Lost to Braves (23-40), 6-5 | Atlanta-Fulton County Stadium (2-2) | 34-31 | Lost 2 |
| » W: Juan Eichelberger (2-0) L: Dave Smith (3-4) | Second | 1 out |
| Saturday, June 18 |
| » Defeated Braves (23-41), 14-7 | Atlanta-Fulton County Stadium (3-2) | 35-31 | |
| » W: Juan Agosto (4-0) L: Paul Assenmacher (2-4) S: Larry Andersen (3) | Second | 1 out |
| Sunday, June 19 |
| » Defeated Braves (23-42), 6-4 | Atlanta-Fulton County Stadium (4-2) | 36-31 | Won 2 |
| » W: Rocky Childress (1-0) L: Bruce Sutter (1-2) S: Dave Smith (13) | Second | 1½ out |
| Monday, June 20 |
| » Lost to Reds (33-35), 2-1 | Astrodome (20-11) | 36-32 | |
| » W: Tom Browning (6-3) L: Jim Deshaies (4-5) S: John Franco (9) | Second | 2½ out |
| Tuesday, June 21 |
| » Defeated Reds (33-36), 3-1 | Astrodome (21-11) | 37-32 | |
| » W: Larry Andersen (2-3) L: Jack Armstrong (0-1) S: Dave Smith (14) | Second | 2½ out |
| » Major-league debuts: Jack Armstrong and Jeff Gray (Reds) |
| Wednesday, June 22 |
| » Defeated Reds (33-37), 5-1 | Astrodome (22-11) | 38-32 | Won 2 |
| » W: Juan Agosto (5-0) L: Danny Jackson (7-4) | Second | 1½ out |
| Friday, June 24 |
| » Lost to Giants (35-36), 11-0 | Astrodome (22-12) | 38-33 | |
| » W: Kelly Downs (5-7) L: Nolan Ryan (5-5) | Second | 2½ out |
| Saturday, June 25 |
| » Lost to Giants (36-36), 4-1 | Astrodome (22-13) | 38-34 | Lost 2 |
| » W: Mike Krukow (6-4) L: Danny Darwin (3-6) | Second | 3½ out |
| Sunday, June 26 |
| » Defeated Giants (36-37), 6-0 | Astrodome (23-13) | 39-34 | |
| » W: Jim Deshaies (5-5) L: Mike LaCoss (5-6) | Second | 3½ out |
| » Major-league debuts: Craig Biggio (Astros) |
| Monday, June 27 |
| » Lost to Dodgers (43-30), 4-0 | Astrodome (23-14) | 39-35 | |
| » W: Shawn Hillegas (2-0) L: Joaquin Andujar (0-3) S: Alejandro Pena (6) | Second | 4½ out |
| Tuesday, June 28 |
| » Defeated Dodgers (43-31), 4-3 | Astrodome (24-14) | 40-35 | |
| » W: Bob Knepper (8-1) L: Brian Holton (3-2) S: Juan Agosto (1) | Second | 3½ out |
| Wednesday, June 29 |
| » Lost to Dodgers (44-31), 2-0 | Astrodome (24-15) | 40-36 | |
| » W: Orel Hershiser (12-3) L: Nolan Ryan (5-6) | Second | 4½ out |
| Thursday, June 30 |
| » Lost to Mets (49-28), 12-6 | Shea Stadium (0-2) | 40-37 | Lost 2 |
| » W: Bob Ojeda (6-6) L: Danny Darwin (3-7) S: Terry Leach (2) | Second | 5 out |
| Friday, July 1 |
| » Lost to Mets (50-28), 3-2 | Shea Stadium (0-3) | 40-38 | Lost 3 |
| » W: Ron Darling (9-5) L: Joaquin Andujar (0-4) S: Randy Myers (12) | Second | 4½ out |
| » Defeated Mets (50-29), 6-5 | Shea Stadium (1-3) | 41-38 | |
| » W: Dave Meads (1-0) L: Gene Walter (0-1) | Second | 4½ out |
| Saturday, July 2 |
| » Lost to Mets (51-29), 7-2 | Shea Stadium (1-4) | 41-39 | |
| » W: Dwight Gooden (11-4) L: Bob Knepper (8-2) | Third | 5½ out |
| Sunday, July 3 |
| » Lost to Mets (52-29), 5-0 | Shea Stadium (1-5) | 41-40 | Lost 2 |
| » W: Sid Fernandez (5-6) L: Nolan Ryan (5-7) | Third | 5½ out |
| Monday, July 4 |
| » Lost to Expos (40-41), 7-4 | Astrodome (24-16) | 41-41 | Lost 3 |
| » W: Dennis Martinez (8-7) L: Danny Darwin (3-8) S: Jeff Parrett (6) | Third | 6½ out |
| Tuesday, July 5 |
| » Lost to Expos (41-41), 4-3 | Astrodome (24-17) | 41-42 | Lost 4 |
| » W: Jeff Parrett (8-2) L: Dave Smith (3-5) S: Neal Heaton (1) | Third | 7½ out |
| Wednesday, July 6 |
| » Lost to Expos (42-41), 4-2 | Astrodome (24-18) | 41-43 | Lost 5 |
| » W: Pascual Perez (6-3) L: Jim Deshaies (5-6) S: Joe Hesketh (4) | Third | 8½ out |
| Thursday, July 7 |
| » Major-league debuts: Terry Clark (Angels) |
| Friday, July 8 |
| » Defeated Mets (53-32), 4-2 | Astrodome (25-18) | 42-43 | |
| » W: Bob Knepper (9-2) L: Dwight Gooden (11-5) | Third | 7½ out |
| Saturday, July 9 |
| » Defeated Mets (53-33), 6-3 | Astrodome (26-18) | 43-43 | Won 2 |
| » W: Nolan Ryan (6-7) L: Rick Aguilera (0-4) S: Juan Agosto (2) | Third | 6½ out |
| Sunday, July 10 |
| » Defeated Mets (53-34), 6-5 | Astrodome (27-18) | 44-43 | Won 3 |
| » W: Juan Agosto (6-0) L: Roger McDowell (4-2) | Third | 5½ out |
| Thursday, July 14 |
| » Defeated Phillies (36-50), 7-5 | Veteran's Stadium (2-1) | 45-43 | Won 4 |
| » W: Juan Agosto (7-0) L: Kent Tekulve (2-6) S: Dave Smith (15) | Third | 6 out |
| Friday, July 15 |
| » Defeated Phillies (36-51), 5-2 | Veteran's Stadium (3-1) | 46-43 | Won 5 |
| » W: Jim Deshaies (6-6) L: Kevin Gross (8-6) S: Danny Darwin (1) | Third | 6 out |
| Saturday, July 16 |
| » Lost to Phillies (37-51), 10-6 | Veteran's Stadium (3-2) | 46-44 | |
| » W: Bruce Ruffin (6-7) L: Danny Darwin (3-9) | Third | 6½ out |
| Sunday, July 17 |
| » Lost to Phillies (38-51), 10-4 | Veteran's Stadium (3-3) | 46-45 | Lost 2 |
| » W: Kent Tekulve (3-6) L: Bob Knepper (9-3) | Third | 8 out |
| » Major-league debuts: Ricky Jordan (Phillies) |
| Monday, July 18 |
| » Defeated Expos (47-44), 6-1 | Stade Olympique (2-2) | 47-45 | |
| » W: Joaquin Andujar (1-4) L: Bryn Smith (6-6) S: Danny Darwin (2) | Second | 8 out |
| Tuesday, July 19 |
| » Defeated Expos (47-45), 4-3 | Stade Olympique (3-2) | 48-45 | Won 2 |
| » W: Mike Scott (9-2) L: Pascual Perez (6-4) S: Dave Smith (16) | Second | 7 out |
| Wednesday, July 20 |
| » Defeated Expos (47-46), 3-2 | Stade Olympique (4-2) | 49-45 | Won 3 |
| » W: Jim Deshaies (7-6) L: John Dopson (2-6) S: Larry Andersen (4) | Third | 6 out |
| Thursday, July 21 |
| » Defeated Phillies (41-53), 2-0 | Astrodome (28-18) | 50-45 | Won 4 |
| » W: Nolan Ryan (7-7) L: Mike Maddux (2-1) | Second | 5 out |
| Friday, July 22 |
| » Defeated Phillies (41-54), 5-3 | Astrodome (29-18) | 51-45 | Won 5 |
| » W: Bob Knepper (10-3) L: David Palmer (5-7) S: Danny Darwin (3) | Second | 5 out |
| Saturday, July 23 |
| » Defeated Phillies (41-55), 7-6 | Astrodome (30-18) | 52-45 | Won 6 |
| » W: Dave Smith (4-5) L: Steve Bedrosian (1-4) | Second | 5 out |
| Sunday, July 24 |
| » Lost to Phillies (42-55), 6-4 | Astrodome (30-19) | 52-46 | |
| » W: Kevin Gross (10-6) L: Mike Scott (9-3) S: Steve Bedrosian (19) | Second | 6 out |
| Tuesday, July 26 |
| » Lost to Padres (46-54), 5-1 | San Diego/Jack Murphy Stadium (0-4) | 52-47 | Lost 2 |
| » W: Dennis Rasmussen (8-7) L: Jim Deshaies (7-7) | Second | 7 out |
| Wednesday, July 27 |
| » Defeated Padres (46-55), 4-1 | San Diego/Jack Murphy Stadium (1-4) | 53-47 | |
| » W: Nolan Ryan (8-7) L: Ed Whitson (9-6) S: Dave Smith (17) | Second | 6 out |
| Thursday, July 28 |
| » Defeated Padres (46-56), 3-2 | San Diego/Jack Murphy Stadium (2-4) | 54-47 | Won 2 |
| » W: Bob Knepper (11-3) L: Eric Show (7-10) S: Larry Andersen (5) | Second | 5½ out |
| Friday, July 29 |
| » Defeated Dodgers (59-42), 3-1 | Dodger Stadium (3-2) | 55-47 | Won 3 |
| » W: Mike Scott (10-3) L: Shawn Hillegas (3-3) | Second | 4½ out |
| Saturday, July 30 |
| » Defeated Dodgers (59-43), 14-6 | Dodger Stadium (4-2) | 56-47 | Won 4 |
| » W: Danny Darwin (4-9) L: Brian Holton (6-3) | Second | 3½ out |
| Sunday, July 31 |
| » Lost to Dodgers (60-43), 6-1 | Dodger Stadium (4-3) | 56-48 | |
| » W: Orel Hershiser (15-5) L: Jim Deshaies (7-8) | Second | 4½ out |
| Monday, August 1 |
| » Lost to Giants (57-48), 4-1 | Candlestick Park (1-3) | 56-49 | Lost 2 |
| » W: Atlee Hammaker (5-3) L: Nolan Ryan (8-8) | Third | 4½ out |
| Tuesday, August 2 |
| » Defeated Giants (57-49), 13-10 | Candlestick Park (2-3) | 57-49 | |
| » W: Danny Darwin (5-9) L: Ron Davis (0-1) S: Dave Smith (18) | Second | 4½ out |
| Wednesday, August 3 |
| » Defeated Giants (57-50), 3-2 | Candlestick Park (3-3) | 58-49 | Won 2 |
| » W: Mike Scott (11-3) L: Scott Garrelts (3-6) S: Dave Smith (19) | Second | 3½ out |
| Friday, August 5 |
| » Defeated Dodgers (61-46), 6-4 | Astrodome (31-19) | 59-49 | Won 3 |
| » W: Jim Deshaies (8-8) L: Orel Hershiser (15-6) S: Dave Smith (20) | Second | 2½ out |
| Saturday, August 6 |
| » Lost to Dodgers (62-46), 5-3 | Astrodome (31-20) | 59-50 | |
| » W: Tim Belcher (8-4) L: Nolan Ryan (8-9) S: Jay Howell (14) | Second | 3½ out |
| Sunday, August 7 |
| » Defeated Dodgers (62-47), 4-2 | Astrodome (32-20) | 60-50 | |
| » W: Bob Knepper (12-3) L: Tim Leary (11-8) S: Juan Agosto (3) | Second | 2½ out |
| Monday, August 8 |
| » Defeated Dodgers (62-48), 10-0 | Astrodome (33-20) | 61-50 | Won 2 |
| » W: Mike Scott (12-3) L: Shawn Hillegas (3-4) | Second | 1½ out |
| Tuesday, August 9 |
| » Defeated Giants (59-53), 3-2 | Astrodome (34-20) | 62-50 | Won 3 |
| » W: Juan Agosto (8-0) L: Kelly Downs (11-9) S: Dave Smith (21) | Second | ½ out |
| Wednesday, August 10 |
| » Lost to Giants (60-53), 5-0 | Astrodome (34-21) | 62-51 | |
| » W: Don Robinson (4-2) L: Jim Deshaies (8-9) | Second | 1½ out |
| Thursday, August 11 |
| » Lost to Giants (61-53), 6-0 | Astrodome (34-22) | 62-52 | Lost 2 |
| » W: Atlee Hammaker (6-4) L: Nolan Ryan (8-10) | Second | 1½ out |
| Friday, August 12 |
| » Lost to Padres (54-61), 4-3 | Astrodome (34-23) | 62-53 | Lost 3 |
| » W: Dennis Rasmussen (11-7) L: Bob Knepper (12-4) S: Mark Davis (20) | Second | 2½ out |
| Saturday, August 13 |
| » Defeated Padres (54-62), 1-0 | Astrodome (35-23) | 63-53 | |
| » W: Mike Scott (13-3) L: Ed Whitson (10-8) | Second | 2½ out |
| Sunday, August 14 |
| » Lost to Padres (55-62), 6-1 | Astrodome (35-24) | 63-54 | |
| » W: Eric Show (10-10) L: Joaquin Andujar (1-5) | Second | 2½ out |
| Monday, August 15 |
| » Defeated Padres (55-63), 7-3 | Astrodome (36-24) | 64-54 | |
| » W: Nolan Ryan (9-10) L: Andy Hawkins (10-10) | Second | 2½ out |
| Tuesday, August 16 |
| » Lost to Cardinals (52-66), 3-0 | Busch Stadium II (2-2) | 64-55 | |
| » W: Scott Terry (3-3) L: Jim Deshaies (8-10) S: Ken Dayley (4) | Second | 3½ out |
| Wednesday, August 17 |
| » Defeated Cardinals (52-67), 1-0 | Busch Stadium II (3-2) | 65-55 | |
| » W: Dave Meads (2-0) L: Joe Magrane (2-7) S: Dave Smith (22) | Second | 3½ out |
| Thursday, August 18 |
| » Lost to Cardinals (53-67), 2-1 | Busch Stadium II (3-3) | 65-56 | |
| » W: Bob Forsch (7-4) L: Mike Scott (13-4) S: Todd Worrell (23) | Second | 4½ out |
| Friday, August 19 |
| » Defeated Pirates (67-55), 5-1 | Three Rivers Stadium (2-2) | 66-56 | |
| » W: Danny Darwin (6-9) L: Mike Dunne (6-10) | Second | 4½ out |
| Saturday, August 20 |
| » Lost to Pirates (68-55), 2-1 | Three Rivers Stadium (2-3) | 66-57 | |
| » W: John Smiley (10-8) L: Nolan Ryan (9-11) S: Jim Gott (23) | Second | 5½ out |
| Sunday, August 21 |
| » Defeated Pirates (68-56), 2-1 | Three Rivers Stadium (3-3) | 67-57 | |
| » W: Juan Agosto (9-0) L: Bob Kipper (2-5) | Second | 5½ out |
| Monday, August 22 |
| » Defeated Cubs (60-62), 9-7 | Wrigley Field (2-2) | 68-57 | Won 2 |
| » W: Juan Agosto (10-0) L: Rich Gossage (2-2) | Second | 4½ out |
| Tuesday, August 23 |
| » Lost to Cubs (61-62), 9-3 | Wrigley Field (2-3) | 68-58 | |
| » W: Jamie Moyer (7-12) L: Danny Darwin (6-10) | Second | 4½ out |
| Wednesday, August 24 |
| » Lost to Cubs (62-62), 3-2 | Wrigley Field (2-4) | 68-59 | Lost 2 |
| » W: Jeff Pico (4-6) L: Juan Agosto (10-1) | Second | 4½ out |
| Friday, August 26 |
| » Defeated Pirates (69-59), 2-0 | Astrodome (37-24) | 69-59 | |
| » W: Jim Deshaies (9-10) L: John Smiley (10-9) | Second | 4½ out |
| Saturday, August 27 |
| » Defeated Pirates (69-60), 3-1 | Astrodome (38-24) | 70-59 | Won 2 |
| » W: Dave Meads (3-0) L: Bob Walk (11-10) S: Juan Agosto (4) | Second | 4½ out |
| Sunday, August 28 |
| » Lost to Pirates (70-60), 4-3 | Astrodome (38-25) | 70-60 | |
| » W: Doug Drabek (13-6) L: Danny Darwin (6-11) S: Jim Gott (25) | Second | 5½ out |
| Monday, August 29 |
| » Lost to Cubs (65-64), 2-1 | Astrodome (38-26) | 70-61 | Lost 2 |
| » W: Scott Sanderson (1-0) L: Larry Andersen (2-4) S: Drew Hall (1) | Second | 6½ out |
| Tuesday, August 30 |
| » Defeated Cubs (65-65), 7-4 | Astrodome (39-26) | 71-61 | |
| » W: Joaquin Andujar (2-5) L: Calvin Schiraldi (8-9) S: Dave Smith (23) | Second | 6½ out |
| Wednesday, August 31 |
| » Lost to Cubs (66-65), 3-1 | Astrodome (39-27) | 71-62 | |
| » W: Rick Sutcliffe (11-11) L: Jim Deshaies (9-11) | Second | 6½ out |
| Friday, September 2 |
| » Lost to Cardinals (63-71), 2-0 | Astrodome (39-28) | 71-63 | Lost 2 |
| » W: Joe Magrane (3-8) L: Mike Scott (13-5) | Second | 6½ out |
| Saturday, September 3 |
| » Defeated Cardinals (63-72), 10-1 | Astrodome (40-28) | 72-63 | |
| » W: Nolan Ryan (10-11) L: Larry McWilliams (4-6) | Second | 5½ out |
| » Major-league debuts: Brian Meyer (Astros) Ken Hill (Cardinals) |
| Sunday, September 4 |
| » Defeated Cardinals (63-73), 4-3 | Astrodome (41-28) | 73-63 | Won 2 |
| » W: Bob Knepper (13-4) L: Greg Mathews (3-5) S: Dave Smith (24) | Second | 5 out |
| Monday, September 5 |
| » Defeated Reds (71-65), 3-0 | Astrodome (42-28) | 74-63 | Won 3 |
| » W: Bob Forsch (10-4) L: Norm Charlton (1-3) S: Dave Smith (25) | Second | 5 out |
| Tuesday, September 6 |
| » Lost to Reds (72-65), 10-3 | Astrodome (42-29) | 74-64 | |
| » W: Tom Browning (15-5) L: Jim Deshaies (9-12) | Second | 5 out |
| Wednesday, September 7 |
| » Lost to Dodgers (79-58), 4-1 | Dodger Stadium (4-4) | 74-65 | Lost 2 |
| » W: Tim Leary (16-9) L: Mike Scott (13-6) S: Jay Howell (18) | Second | 6 out |
| Thursday, September 8 |
| » Defeated Dodgers (79-59), 2-1 | Dodger Stadium (5-4) | 75-65 | |
| » W: Nolan Ryan (11-11) L: John Tudor (8-8) | Second | 5 out |
| Friday, September 9 |
| » Defeated Giants (71-70), 4-3 | Candlestick Park (4-3) | 76-65 | Won 2 |
| » W: Danny Darwin (7-11) L: Scott Garrelts (5-9) | Second | 4 out |
| Saturday, September 10 |
| » Lost to Giants (72-70), 3-2 | Candlestick Park (4-4) | 76-66 | |
| » W: Craig Lefferts (3-8) L: Juan Agosto (10-2) S: Lary Sorensen (2) | Second | 5 out |
| Sunday, September 11 |
| » Defeated Giants (72-71), 4-1 | Candlestick Park (5-4) | 77-66 | |
| » W: Jim Deshaies (10-12) L: Atlee Hammaker (7-8) | Second | 5 out |
| » Major-league debuts: Charlie Hayes (Giants) |
| Tuesday, September 13 |
| » Lost to Reds (75-68), 5-2 | Riverfront Stadium (3-4) | 77-67 | |
| » W: Jose Rijo (13-8) L: Mike Scott (13-7) S: John Franco (33) | Second | 6½ out |
| Wednesday, September 14 |
| » Defeated Reds (75-69), 7-1 | Riverfront Stadium (4-4) | 78-67 | |
| » W: Nolan Ryan (12-11) L: Danny Jackson (21-7) | Second | 6½ out |
| Thursday, September 15 |
| » Lost to Reds (76-69), 7-5 | Riverfront Stadium (4-5) | 78-68 | |
| » W: Norm Charlton (2-4) L: Bob Forsch (10-5) S: John Franco (34) | Second | 7 out |
| Friday, September 16 |
| » Lost to Giants (76-71), 5-4 | Astrodome (42-30) | 78-69 | Lost 2 |
| » W: Atlee Hammaker (8-8) L: Bob Knepper (13-5) S: Craig Lefferts (10) | Second | 7 out |
| Saturday, September 17 |
| » Lost to Giants (77-71), 4-2 | Astrodome (42-31) | 78-70 | Lost 3 |
| » W: Rick Reuschel (19-8) L: Jim Deshaies (10-13) | Second | 8 out |
| Sunday, September 18 |
| » Lost to Giants (78-71), 10-3 | Astrodome (42-32) | 78-71 | Lost 4 |
| » W: Don Robinson (8-4) L: Mike Scott (13-8) | Second | 9 out |
| Monday, September 19 |
| » Lost to Dodgers (87-61), 1-0 | Astrodome (42-33) | 78-72 | Lost 5 |
| » W: Orel Hershiser (22-8) L: Danny Darwin (7-12) | Third | 10 out |
| Tuesday, September 20 |
| » Lost to Dodgers (88-61), 6-0 | Astrodome (42-34) | 78-73 | Lost 6 |
| » W: Tim Belcher (11-5) L: Bob Forsch (10-6) | Fourth | 11 out |
| Wednesday, September 21 |
| » Defeated Braves (52-98), 1-0 | Astrodome (43-34) | 79-73 | |
| » W: Bob Knepper (14-5) L: Pete Smith (7-15) | Third | 10½ out |
| Thursday, September 22 |
| » Defeated Braves (52-99), 3-2 | Astrodome (44-34) | 80-73 | Won 2 |
| » W: Jim Deshaies (11-13) L: Tom Glavine (7-17) S: Dave Smith (26) | Third | 9½ out |
| Friday, September 23 |
| » Lost to Padres (76-77), 4-3 | San Diego/Jack Murphy Stadium (2-5) | 80-74 | |
| » W: Dave Leiper (2-0) L: Danny Darwin (7-13) | Third | 10½ out |
| Saturday, September 24 |
| » Lost to |