| Monday, March 9 |
| Former White Sox Zeke Bonura dies in New Orleans, LA at the age of 79. |
| Monday, April 6 |
| » Defeated Royals (0-1), 5-4 | Royals Stadium (1-0) | 1-0 | |
| » W: Richard Dotson (1-0) L: Danny Jackson (0-1) S: Bob James (1) | First | -- |
| Wednesday, April 8 |
| » Lost to Royals (1-1), 9-3 | Royals Stadium (1-1) | 1-1 | |
| » W: Charlie Leibrandt (1-0) L: Floyd Bannister (0-1) | Second | 1 out |
| Thursday, April 9 |
| » Defeated Royals (1-2), 6-0 | Royals Stadium (2-1) | 2-1 | |
| » W: Jose DeLeon (1-0) L: Mark Gubicza (0-1) S: Bobby Thigpen (1) | Second | 1 out |
| Friday, April 10 |
| » Lost to Tigers (2-2), 11-4 | Comiskey Park I (0-1) | 2-2 | |
| » W: Frank Tanana (1-0) L: Neil Allen (0-1) | Third | 2 out |
| Saturday, April 11 |
| » Lost to Tigers (3-2), 7-1 | Comiskey Park I (0-2) | 2-3 | Lost 2 |
| » W: Jack Morris (1-1) L: Richard Dotson (1-1) | Second | 2 out |
| Sunday, April 12 |
| » Lost to Tigers (4-2), 7-1 | Comiskey Park I (0-3) | 2-4 | Lost 3 |
| » W: Jeff Robinson (1-0) L: Joel Davis (0-1) | Fourth | 3 out |
| Tuesday, April 14 |
| » Lost to Blue Jays (4-3), 4-3 | Exhibition Stadium (0-1) | 2-5 | Lost 4 |
| » W: Mark Eichhorn (1-0) L: Joel McKeon (0-1) | Fifth | 3½ out |
| Wednesday, April 15 |
| » Defeated Blue Jays (4-4), 5-0 | Exhibition Stadium (1-1) | 3-5 | |
| » W: Jose DeLeon (2-0) L: Dave Stieb (0-2) | Fourth | 3½ out |
| Friday, April 17 |
| » Lost to Tigers (5-4), 3-1 | Tiger Stadium (0-1) | 3-6 | |
| » W: Frank Tanana (2-0) L: Richard Dotson (1-2) S: Mark Thurmond (1) | Fourth | 3½ out |
| Saturday, April 18 |
| » Lost to Tigers (6-4), 3-2 | Tiger Stadium (0-2) | 3-7 | Lost 2 |
| » W: Eric King (1-0) L: Bobby Thigpen (0-1) | Fifth | 4½ out |
| Sunday, April 19 |
| » Defeated Tigers (6-5), 7-2 | Tiger Stadium (1-2) | 4-7 | |
| » W: Floyd Bannister (1-1) L: Dan Petry (0-2) | Fourth | 3½ out |
| Monday, April 20 |
| » Lost to Brewers (13-0), 5-4 | Comiskey Park I (0-4) | 4-8 | |
| » W: Chuck Crim (2-0) L: Jose DeLeon (2-1) S: Dan Plesac (5) | Fifth | 4½ out |
| Tuesday, April 21 |
| » Defeated Brewers (13-1), 7-1 | Comiskey Park I (1-4) | 5-8 | |
| » W: Joel Davis (1-1) L: Mark Ciardi (1-1) S: Jim Winn (1) | Fifth | 4½ out |
| Friday, April 24 |
| » Lost to Blue Jays (9-7), 4-2 | Comiskey Park I (1-5) | 5-9 | |
| » W: Mark Eichhorn (3-0) L: Bob James (0-1) S: Tom Henke (3) | Fifth | 4½ out |
| Saturday, April 25 |
| » Defeated Blue Jays (9-8), 5-4 | Comiskey Park I (2-5) | 6-9 | |
| » W: Bob James (1-1) L: Mark Eichhorn (3-1) | Fourth | 3½ out |
| Sunday, April 26 |
| » Lost to Blue Jays (10-8), 5-2 | Comiskey Park I (2-6) | 6-10 | |
| » W: Jimmy Key (4-1) L: Jose DeLeon (2-2) S: Tom Henke (4) | Fifth | 4½ out |
| Tuesday, April 28 |
| » Lost to Indians (7-14), 1-0 | Cleveland Stadium (0-1) | 6-11 | Lost 2 |
| » W: Ken Schrom (1-2) L: Joel Davis (1-2) | Seventh | 4½ out |
| Wednesday, April 29 |
| » Lost to Indians (8-14), 6-5 | Cleveland Stadium (0-2) | 6-12 | Lost 3 |
| » W: Rich Yett (1-0) L: Bob James (1-2) | Seventh | 4½ out |
| Friday, May 1 |
| » Defeated Orioles (9-13), 5-1 | Memorial Stadium (1-0) | 7-12 | |
| » W: Floyd Bannister (2-1) L: Scott McGregor (0-4) | Sixth | 4½ out |
| Saturday, May 2 |
| » Defeated Orioles (9-14), 7-3 | Memorial Stadium (2-0) | 8-12 | Won 2 |
| » W: Jose DeLeon (3-2) L: Mike Flanagan (0-4) S: Jim Winn (2) | Sixth | 3½ out |
| Sunday, May 3 |
| » Defeated Orioles (9-15), 4-3 | Memorial Stadium (3-0) | 9-12 | Won 3 |
| » W: Bobby Thigpen (1-1) L: Mike Boddicker (2-1) S: Ray Searage (1) | Sixth | 3½ out |
| Monday, May 4 |
| » Lost to Yankees (16-9), 6-1 | Comiskey Park I (2-7) | 9-13 | |
| » W: Charles Hudson (4-0) L: Richard Dotson (1-3) | Sixth | 4 out |
| Tuesday, May 5 |
| » Defeated Yankees (16-10), 2-0 | Comiskey Park I (3-7) | 10-13 | |
| » W: Bill Long (1-0) L: Joe Niekro (1-2) | Sixth | 3 out |
| Wednesday, May 6 |
| » Lost to Yankees (17-10), 4-1 | Comiskey Park I (3-8) | 10-14 | |
| » W: Rick Rhoden (3-3) L: Floyd Bannister (2-2) | Sixth | 4 out |
| Friday, May 8 |
| » Lost to Orioles (12-16), 7-6 | Comiskey Park I (3-9) | 10-15 | Lost 2 |
| » W: Ken Dixon (2-2) L: Ray Searage (0-1) | Sixth | 4 out |
| Saturday, May 9 |
| » Lost to Orioles (13-16), 15-6 | Comiskey Park I (3-10) | 10-16 | Lost 3 |
| » W: Dave J. Schmidt (3-1) L: Joel McKeon (0-2) | Sixth | 5 out |
| » Major-league debuts: Jeff Ballard (Orioles) |
| Sunday, May 10 |
| » Lost to Orioles (14-16), 6-4 | Comiskey Park I (3-11) | 10-17 | Lost 4 |
| » W: Eric Bell (4-1) L: Richard Dotson (1-4) S: Mark Williamson (2) | Sixth | 5 out |
| Monday, May 11 |
| » Lost to Yankees (20-11), 3-2 | Yankee Stadium (0-1) | 10-18 | Lost 5 |
| » W: Rick Rhoden (4-3) L: Floyd Bannister (2-3) S: Dave Righetti (8) | Sixth | 6 out |
| Tuesday, May 12 |
| » Lost to Yankees (21-11), 5-4 | Yankee Stadium (0-2) | 10-19 | Lost 6 |
| » W: Cecilio Guante (3-1) L: Bobby Thigpen (1-2) | Sixth | 6 out |
| Wednesday, May 13 |
| » Lost to Indians (11-22), 7-5 | Comiskey Park I (3-12) | 10-20 | Lost 7 |
| » W: Ken Schrom (2-4) L: Jose DeLeon (3-3) S: Scott Bailes (1) | Seventh | 7 out |
| Thursday, May 14 |
| » Defeated Indians (11-23), 4-3 | Comiskey Park I (4-12) | 11-20 | |
| » W: Bobby Thigpen (2-2) L: Rich Yett (1-2) | Seventh | 6½ out |
| Former White Sox Luke Sewell dies in Akron, OH at the age of 87. |
| Friday, May 15 |
| » Defeated Rangers (14-18), 5-0 | Comiskey Park I (5-12) | 12-20 | Won 2 |
| » W: Richard Dotson (2-4) L: Bobby Witt (1-2) | Sixth | 6 out |
| Saturday, May 16 |
| » Lost to Rangers (15-18), 7-2 | Comiskey Park I (5-13) | 12-21 | |
| » W: Dale Mohorcic (2-1) L: Jim Winn (0-1) | Seventh | 7 out |
| Sunday, May 17 |
| » Defeated Rangers (15-19), 8-5 | Comiskey Park I (6-13) | 13-21 | |
| » W: Joel McKeon (1-2) L: Greg Harris (1-4) S: Bob James (2) | Sixth | 7 out |
| Tuesday, May 19 |
| » Defeated Brewers (20-15), 5-1 | County Stadium (1-0) | 14-21 | Won 2 |
| » W: Jose DeLeon (4-3) L: Teddy Higuera (4-3) S: Bob James (3) | Fifth | 7½ out |
| Wednesday, May 20 |
| » Lost to Brewers (21-15), 5-1 | County Stadium (1-1) | 14-22 | |
| » W: Juan Nieves (3-1) L: Joel Davis (1-3) | Fifth | 7½ out |
| Friday, May 22 |
| » Defeated Red Sox (17-23), 4-3 | Fenway Park (1-0) | 15-22 | |
| » W: Jim Winn (1-1) L: Roger Clemens (3-4) S: Bob James (4) | Sixth | 7½ out |
| Saturday, May 23 |
| » Defeated Red Sox (17-24), 9-1 | Fenway Park (2-0) | 16-22 | Won 2 |
| » W: Floyd Bannister (3-3) L: Al Nipper (3-4) | Fifth | 6½ out |
| Sunday, May 24 |
| » Defeated Red Sox (17-25), 4-1 | Fenway Park (3-0) | 17-22 | Won 3 |
| » W: Ray Searage (1-1) L: Bob Stanley (2-6) S: Bob James (5) | Fifth | 6½ out |
| Monday, May 25 |
| » Lost to Royals (25-16), 6-1 | Comiskey Park I (6-14) | 17-23 | |
| » W: Bret Saberhagen (8-1) L: Joel Davis (1-4) | Sixth | 7½ out |
| Tuesday, May 26 |
| » Lost to Royals (26-16), 5-4 | Comiskey Park I (6-15) | 17-24 | Lost 2 |
| » W: Danny Jackson (2-6) L: Bill Long (1-1) S: Dan Quisenberry (6) | Fifth | 8½ out |
| Wednesday, May 27 |
| » Defeated Royals (26-17), 3-2 | Comiskey Park I (7-15) | 18-24 | |
| » W: Richard Dotson (3-4) L: Charlie Leibrandt (6-3) S: Bob James (6) | Fifth | 7½ out |
| Friday, May 29 |
| » Defeated Red Sox (21-26), 8-6 | Comiskey Park I (8-15) | 19-24 | Won 2 |
| » W: Jim Winn (2-1) L: Bob Stanley (2-7) S: Bob James (7) | Fifth | 6½ out |
| Saturday, May 30 |
| » Defeated Red Sox (21-27), 3-2 | Comiskey Park I (9-15) | 20-24 | Won 3 |
| » W: Bob James (2-2) L: Wes Gardner (0-2) | Fourth | 6½ out |
| Sunday, May 31 |
| » Lost to Red Sox (22-27), 10-9 | Comiskey Park I (9-16) | 20-25 | |
| » W: Calvin Schiraldi (2-3) L: Ray Searage (1-2) | Fourth | 6½ out |
| Former White Sox Jerry Adair dies in Tulsa, OK at the age of 51. |
| Monday, June 1 |
| » Lost to Rangers (20-27), 11-9 | Arlington Stadium (0-1) | 20-26 | Lost 2 |
| » W: Dale Mohorcic (5-2) L: Joel Davis (1-5) | Fifth | 6½ out |
| Tuesday, June 2 |
| » Defeated Rangers (20-28), 15-5 | Arlington Stadium (1-1) | 21-26 | |
| » W: Bill Long (2-1) L: Charlie Hough (5-2) | Fourth | 5½ out |
| Wednesday, June 3 |
| » Lost to Rangers (21-28), 14-3 | Arlington Stadium (1-2) | 21-27 | |
| » W: Jose Guzman (3-5) L: Floyd Bannister (3-4) | Fourth | 5½ out |
| Thursday, June 4 |
| » Lost to Angels (23-30), 3-2 | Anaheim Stadium (0-1) | 21-28 | Lost 2 |
| » W: Jack Lazorko (1-2) L: Jose DeLeon (4-4) | Sixth | 6½ out |
| Friday, June 5 |
| » Lost to Angels (24-30), 6-4 | Anaheim Stadium (0-2) | 21-29 | Lost 3 |
| » W: John Candelaria (5-2) L: Neil Allen (0-2) S: DeWayne Buice (3) | Seventh | 6½ out |
| Saturday, June 6 |
| » Lost to Angels (25-30), 2-1 | Anaheim Stadium (0-3) | 21-30 | Lost 4 |
| » W: Mike Witt (7-4) L: Bob James (2-3) | Seventh | 7½ out |
| Sunday, June 7 |
| » Defeated Angels (25-31), 4-0 | Anaheim Stadium (1-3) | 22-30 | |
| » W: Bill Long (3-1) L: Willie Fraser (2-4) | Sixth | 7½ out |
| Monday, June 8 |
| » Lost to Athletics (28-27), 9-3 | Oakland-Alameda County Stadium (0-1) | 22-31 | |
| » W: Steve Ontiveros (1-1) L: Floyd Bannister (3-5) S: Jay Howell (10) | Sixth | 7½ out |
| Tuesday, June 9 |
| » Lost to Athletics (29-27), 8-3 | Oakland-Alameda County Stadium (0-2) | 22-32 | Lost 2 |
| » W: Curt Young (8-3) L: Jose DeLeon (4-5) | Seventh | 7½ out |
| Wednesday, June 10 |
| » Lost to Athletics (30-27), 5-2 | Oakland-Alameda County Stadium (0-3) | 22-33 | Lost 3 |
| » W: Dennis Eckersley (5-4) L: Neil Allen (0-3) S: Jay Howell (11) | Seventh | 8½ out |
| Friday, June 12 |
| » Lost to Twins (33-26), 5-2 | Comiskey Park I (9-17) | 22-34 | Lost 4 |
| » W: Frank Viola (5-5) L: Bill Long (3-2) S: Jeff Reardon (12) | Seventh | 10½ out |
| » Lost to Twins (34-26), 7-4 | Comiskey Park I (9-18) | 22-35 | Lost 5 |
| » W: Juan Berenguer (4-0) L: Scott Nielsen (0-1) S: Keith Atherton (2) | Seventh | 10½ out |
| Saturday, June 13 |
| » Defeated Twins (34-27), 6-2 | Comiskey Park I (10-18) | 23-35 | |
| » W: Richard Dotson (4-4) L: Les Straker (2-3) S: Bob James (8) | Seventh | 9½ out |
| Sunday, June 14 |
| » Lost to Twins (35-27), 6-3 | Comiskey Park I (10-19) | 23-36 | |
| » W: Joe Niekro (5-4) L: Jose DeLeon (4-6) S: Juan Berenguer (2) | Seventh | 10½ out |
| Monday, June 15 |
| » Lost to Mariners (31-32), 8-2 | Kingdome (0-1) | 23-37 | Lost 2 |
| » W: Lee Guetterman (4-0) L: Floyd Bannister (3-6) S: Jerry Reed (1) | Seventh | 11½ out |
| Tuesday, June 16 |
| » Lost to Mariners (32-32), 8-6 | Kingdome (0-2) | 23-38 | Lost 3 |
| » W: Bill Wilkinson (1-2) L: Jim Winn (2-2) | Seventh | 12½ out |
| Wednesday, June 17 |
| » Lost to Mariners (33-32), 2-0 | Kingdome (0-3) | 23-39 | Lost 4 |
| » W: Scott Bankhead (7-4) L: Bill Long (3-3) S: Ed Nunez (8) | Seventh | 12½ out |
| Friday, June 19 |
| » Lost to Twins (38-28), 7-6 | Hubert H. Humphrey Metrodome (0-1) | 23-40 | Lost 5 |
| » W: Jeff Reardon (4-4) L: Jim Winn (2-3) | Sixth | 13½ out |
| Saturday, June 20 |
| » Defeated Twins (38-29), 10-5 | Hubert H. Humphrey Metrodome (1-1) | 24-40 | |
| » W: Jose DeLeon (5-6) L: Bert Blyleven (5-6) | Seventh | 12½ out |
| Sunday, June 21 |
| » Lost to Twins (39-29), 8-6 | Hubert H. Humphrey Metrodome (1-2) | 24-41 | |
| » W: Juan Berenguer (5-0) L: Jim Winn (2-4) S: Jeff Reardon (14) | Seventh | 13½ out |
| Monday, June 22 |
| » Lost to Mariners (36-33), 3-0 | Comiskey Park I (10-20) | 24-42 | Lost 2 |
| » W: Mike Moore (3-8) L: Scott Nielsen (0-2) S: Bill Wilkinson (3) | Seventh | 14 out |
| Tuesday, June 23 |
| » Defeated Mariners (36-34), 13-3 | Comiskey Park I (11-20) | 25-42 | |
| » W: Bill Long (4-3) L: Scott Bankhead (7-5) | Seventh | 14 out |
| Wednesday, June 24 |
| » Lost to Mariners (37-34), 10-7 | Comiskey Park I (11-21) | 25-43 | |
| » W: Mark Langston (9-6) L: Richard Dotson (4-5) S: Ed Nunez (9) | Seventh | 15 out |
| Friday, June 26 |
| » Lost to Angels (35-38), 3-1 | Comiskey Park I (11-22) | 25-44 | Lost 2 |
| » W: Jerry Reuss (2-5) L: Jose DeLeon (5-7) S: Greg Minton (4) | Seventh | 15½ out |
| Saturday, June 27 |
| » Lost to Angels (36-38), 3-1 | Comiskey Park I (11-23) | 25-45 | Lost 3 |
| » W: Mike Witt (9-5) L: Floyd Bannister (3-7) S: DeWayne Buice (6) | Seventh | 15 out |
| Sunday, June 28 |
| » Lost to Angels (37-38), 13-3 | Comiskey Park I (11-24) | 25-46 | Lost 4 |
| » W: Willie Fraser (5-5) L: Bill Long (4-4) | Seventh | 15 out |
| Monday, June 29 |
| » Defeated Athletics (40-34), 5-2 | Comiskey Park I (12-24) | 26-46 | |
| » W: Richard Dotson (5-5) L: Curt Young (9-5) | Seventh | 14 out |
| Tuesday, June 30 |
| » Defeated Athletics (40-35), 12-3 | Comiskey Park I (13-24) | 27-46 | Won 2 |
| » W: Scott Nielsen (1-2) L: Jose Rijo (0-4) | Seventh | 14 out |
| Wednesday, July 1 |
| » Defeated Athletics (40-36), 5-3 | Comiskey Park I (14-24) | 28-46 | Won 3 |
| » W: Jim Winn (3-4) L: Jay Howell (2-2) | Seventh | 13 out |
| Thursday, July 2 |
| » Lost to Indians (27-50), 2-1 | Cleveland Stadium (0-3) | 28-47 | |
| » W: Doug Jones (1-1) L: Bob James (2-4) | Seventh | 13 out |
| Friday, July 3 |
| » Defeated Indians (27-51), 14-9 | Cleveland Stadium (1-3) | 29-47 | |
| » W: Jim Winn (4-4) L: Sammy Stewart (0-1) | Seventh | 13 out |
| Saturday, July 4 |
| » Defeated Indians (27-52), 3-2 | Cleveland Stadium (2-3) | 30-47 | Won 2 |
| » W: Richard Dotson (6-5) L: Scott Bailes (2-2) S: Bob James (9) | Seventh | 13 out |
| Sunday, July 5 |
| » Defeated Indians (27-53), 17-0 | Cleveland Stadium (3-3) | 31-47 | Won 3 |
| » W: Scott Nielsen (2-2) L: Phil Niekro (6-8) | Seventh | 13 out |
| Monday, July 6 |
| » Lost to Orioles (32-50), 4-1 | Memorial Stadium (3-1) | 31-48 | |
| » W: Mike Griffin (1-2) L: Jose DeLeon (5-8) S: Mark Williamson (3) | Seventh | 14 out |
| Tuesday, July 7 |
| » Defeated Orioles (32-51), 9-3 | Memorial Stadium (4-1) | 32-48 | |
| » W: Floyd Bannister (4-7) L: John Habyan (1-3) | Seventh | 13 out |
| Wednesday, July 8 |
| » Lost to Orioles (33-51), 6-5 | Memorial Stadium (4-2) | 32-49 | |
| » W: Mike Boddicker (6-4) L: Jim Winn (4-5) | Seventh | 13 out |
| Thursday, July 9 |
| » Defeated Yankees (53-33), 6-3 | Yankee Stadium (1-2) | 33-49 | |
| » W: Richard Dotson (7-5) L: Bob Tewksbury (1-4) S: Bob James (10) | Seventh | 13 out |
| Friday, July 10 |
| » Lost to Yankees (54-33), 9-5 | Yankee Stadium (1-3) | 33-50 | |
| » W: Dennis Rasmussen (8-4) L: Scott Nielsen (2-3) | Sixth | 13 out |
| Saturday, July 11 |
| » Defeated Yankees (54-34), 5-2 | Yankee Stadium (2-3) | 34-50 | |
| » W: Bill Long (5-4) L: Pat Clements (2-1) | Sixth | 13 out |
| Sunday, July 12 |
| » Lost to Yankees (55-34), 6-2 | Yankee Stadium (2-4) | 34-51 | |
| » W: Tommy John (8-3) L: Floyd Bannister (4-8) | Sixth | 13 out |
| Thursday, July 16 |
| » Lost to Indians (32-56), 4-3 | Comiskey Park I (14-25) | 34-52 | Lost 2 |
| » W: Scott Bailes (3-2) L: Richard Dotson (7-6) S: Sammy Stewart (1) | Seventh | 13 out |
| Friday, July 17 |
| » Defeated Indians (32-57), 4-3 | Comiskey Park I (15-25) | 35-52 | |
| » W: Bob James (3-4) L: Doug Jones (3-3) | Seventh | 13 out |
| Saturday, July 18 |
| » Defeated Indians (32-58), 6-3 | Comiskey Park I (16-25) | 36-52 | Won 2 |
| » W: Bobby Thigpen (3-2) L: Tom Candiotti (2-10) S: Jim Winn (3) | Seventh | 12 out |
| » Major-league debuts: Bill Lindsey (White Sox) |
| Sunday, July 19 |
| » Defeated Indians (32-59), 9-7 | Comiskey Park I (17-25) | 37-52 | Won 3 |
| » W: Scott Nielsen (3-3) L: Steve Carlton (5-8) S: Jim Winn (4) | Seventh | 12 out |
| Monday, July 20 |
| » Lost to Orioles (40-53), 4-1 | Comiskey Park I (17-26) | 37-53 | |
| » W: Mike Griffin (2-3) L: Neil Allen (0-4) S: Doug Corbett (1) | Seventh | 12 out |
| Tuesday, July 21 |
| » Lost to Orioles (41-53), 11-6 | Comiskey Park I (17-27) | 37-54 | Lost 2 |
| » W: Mark Williamson (4-6) L: Bill Long (5-5) | Seventh | 13 out |
| Wednesday, July 22 |
| » Lost to Orioles (42-53), 10-5 | Comiskey Park I (17-28) | 37-55 | Lost 3 |
| » W: John Habyan (2-3) L: Jose DeLeon (5-9) | Seventh | 14 out |
| Former White Sox Don McMahon dies in Los Angeles, CA at the age of 58. |
| Thursday, July 23 |
| » Major-league debuts: Mike Macfarlane (Royals) |
| Friday, July 24 |
| » Defeated Yankees (58-39), 5-2 | Comiskey Park I (18-28) | 38-55 | |
| » W: Floyd Bannister (5-8) L: Steve Trout (6-5) S: Jim Winn (5) | Seventh | 12½ out |
| Saturday, July 25 |
| » Defeated Yankees (58-40), 3-2 | Comiskey Park I (19-28) | 39-55 | Won 2 |
| » W: Ray Searage (2-2) L: Pat Clements (2-2) S: Jim Winn (6) | Seventh | 12½ out |
| Sunday, July 26 |
| » Lost to Yankees (59-40), 5-2 | Comiskey Park I (19-29) | 39-56 | |
| » W: Ron Guidry (3-4) L: Richard Dotson (7-7) S: Dave Righetti (18) | Seventh | 12½ out |
| Monday, July 27 |
| » Lost to Tigers (57-39), 4-1 | Tiger Stadium (1-3) | 39-57 | Lost 2 |
| » W: Frank Tanana (10-7) L: Scott Nielsen (3-4) | Sixth | 13½ out |
| Tuesday, July 28 |
| » Lost to Tigers (58-39), 3-1 | Tiger Stadium (1-4) | 39-58 | Lost 3 |
| » W: Jeff Robinson (7-4) L: Bill Long (5-6) | Sixth | 13½ out |
| Wednesday, July 29 |
| » Defeated Tigers (58-40), 4-0 | Tiger Stadium (2-4) | 40-58 | |
| » W: Floyd Bannister (6-8) L: Jack Morris (12-5) | Sixth | 12½ out |
| Thursday, July 30 |
| » Lost to Brewers (52-48), 6-1 | County Stadium (1-2) | 40-59 | |
| » W: Mark Knudson (1-2) L: Neil Allen (0-5) S: Chuck Crim (1) | Sixth | 13 out |
| Friday, July 31 |
| » Defeated Brewers (52-49), 8-6 | County Stadium (2-2) | 41-59 | |
| » W: Richard Dotson (8-7) L: Teddy Higuera (10-8) S: Bobby Thigpen (2) | Sixth | 13 out |
| Saturday, August 1 |
| » Defeated Brewers (52-50), 3-2 | County Stadium (3-2) | 42-59 | Won 2 |
| » W: Dave LaPoint (2-1) L: Bill Wegman (8-10) S: Ray Searage (2) | Seventh | 12 out |
| Sunday, August 2 |
| » Defeated Brewers (52-51), 7-3 | County Stadium (4-2) | 43-59 | Won 3 |
| » W: Bill Long (6-6) L: Chris Bosio (7-3) S: Bobby Thigpen (3) | Seventh | 11 out |
| Monday, August 3 |
| » Lost to Blue Jays (62-43), 14-5 | Comiskey Park I (19-30) | 43-60 | |
| » W: Jeff Musselman (10-4) L: Floyd Bannister (6-9) | Seventh | 12 out |
| Tuesday, August 4 |
| » Lost to Blue Jays (63-43), 4-1 | Comiskey Park I (19-31) | 43-61 | Lost 2 |
| » W: John Cerutti (7-2) L: Neil Allen (0-6) S: Tom Henke (24) | Seventh | 12 out |
| Wednesday, August 5 |
| » Lost to Blue Jays (64-43), 3-2 | Comiskey Park I (19-32) | 43-62 | Lost 3 |
| » W: Jimmy Key (13-6) L: Richard Dotson (8-8) S: Tom Henke (25) | Seventh | 12 out |
| Friday, August 7 |
| » Lost to Brewers (56-51), 7-4 | Comiskey Park I (19-33) | 43-63 | Lost 4 |
| » W: Mark Clear (6-5) L: Bobby Thigpen (3-3) S: Dan Plesac (21) | Seventh | 13½ out |
| Saturday, August 8 |
| » Lost to Brewers (57-51), 5-3 | Comiskey Park I (19-34) | 43-64 | Lost 5 |
| » W: Ray Burris (1-0) L: Jose DeLeon (5-10) S: Chuck Crim (3) | Seventh | 14 out |
| » Defeated Brewers (57-52), 8-6 | Comiskey Park I (20-34) | 44-64 | |
| » W: Floyd Bannister (7-9) L: Chris Bosio (7-4) S: Bobby Thigpen (4) | Seventh | 14 out |
| Sunday, August 9 |
| » Lost to Brewers (58-52), 8-4 | Comiskey Park I (20-35) | 44-65 | |
| » W: Juan Nieves (8-6) L: Neil Allen (0-7) | Seventh | 15 out |
| Monday, August 10 |
| » Defeated Tigers (63-46), 8-4 | Comiskey Park I (21-35) | 45-65 | |
| » W: Richard Dotson (9-8) L: Walt Terrell (9-9) | Sixth | 14½ out |
| Tuesday, August 11 |
| » Lost to Tigers (64-46), 9-6 | Comiskey Park I (21-36) | 45-66 | |
| » W: Frank Tanana (13-7) L: Scott Nielsen (3-5) S: Guillermo Hernandez (6) | Sixth | 15½ out |
| Wednesday, August 12 |
| » Lost to Tigers (65-46), 8-7 | Comiskey Park I (21-37) | 45-67 | Lost 2 |
| » W: Guillermo Hernandez (2-2) L: Bobby Thigpen (3-4) | Seventh | 15½ out |
| Thursday, August 13 |
| » Defeated Blue Jays (68-47), 10-3 | Exhibition Stadium (2-1) | 46-67 | |
| » W: Floyd Bannister (8-9) L: Phil Niekro (7-12) | Sixth | 14½ out |
| Friday, August 14 |
| » Lost to Blue Jays (69-47), 3-2 | Exhibition Stadium (2-2) | 46-68 | |
| » W: John Cerutti (9-2) L: Jose DeLeon (5-11) S: Tom Henke (26) | Sixth | 15½ out |
| Saturday, August 15 |
| » Defeated Blue Jays (69-48), 1-0 | Exhibition Stadium (3-2) | 47-68 | |
| » W: Richard Dotson (10-8) L: Jim Clancy (10-10) | Seventh | 15½ out |
| Sunday, August 16 |
| » Lost to Blue Jays (70-48), 6-4 | Exhibition Stadium (3-3) | 47-69 | |
| » W: Mark Eichhorn (10-5) L: Ray Searage (2-3) S: Tom Henke (27) | Seventh | 16½ out |
| Monday, August 17 |
| » Defeated Red Sox (56-62), 2-1 | Comiskey Park I (22-37) | 48-69 | |
| » W: Dave LaPoint (3-1) L: Jeff Sellers (4-6) S: Bobby Thigpen (5) | Seventh | 16½ out |
| Tuesday, August 18 |
| » Lost to Red Sox (57-62), 14-8 | Comiskey Park I (22-38) | 48-70 | |
| » W: Al Nipper (8-10) L: Floyd Bannister (8-10) | Seventh | 16½ out |
| Wednesday, August 19 |
| » Defeated Red Sox (57-63), 8-3 | Comiskey Park I (23-38) | 49-70 | |
| » W: Jose DeLeon (6-11) L: Bruce Hurst (14-7) S: Bobby Thigpen (6) | Seventh | 15½ out |
| Thursday, August 20 |
| » Lost to Rangers (57-63), 5-1 | Arlington Stadium (1-3) | 49-71 | |
| » W: Jose Guzman (10-11) L: Richard Dotson (10-9) | Seventh | 15½ out |
| Friday, August 21 |
| » Defeated Rangers (57-64), 5-1 | Arlington Stadium (2-3) | 50-71 | |
| » W: Bill Long (7-6) L: Paul Kilgus (2-5) | Seventh | 14½ out |
| Saturday, August 22 |
| » Lost to Rangers (58-64), 8-6 | Arlington Stadium (2-4) | 50-72 | |
| » W: Charlie Hough (14-8) L: Dave LaPoint (3-2) S: Mitch Williams (3) | Seventh | 14½ out |
| Sunday, August 23 |
| » Defeated Rangers (58-65), 8-1 | Arlington Stadium (3-4) | 51-72 | |
| » W: Floyd Bannister (9-10) L: Jeff Russell (4-4) | Seventh | 13½ out |
| Monday, August 24 |
| » Defeated Red Sox (60-64), 6-3 | Fenway Park (4-0) | 52-72 | Won 2 |
| » W: Jose DeLeon (7-11) L: Bruce Hurst (14-8) S: Scott Nielsen (1) | Seventh | 13½ out |
| Tuesday, August 25 |
| » Lost to Red Sox (61-64), 7-3 | Fenway Park (4-1) | 52-73 | |
| » W: Steve Crawford (5-3) L: Richard Dotson (10-10) S: Wes Gardner (7) | Seventh | 13½ out |
| Wednesday, August 26 |
| » Defeated Red Sox (61-65), 5-3 | Fenway Park (5-1) | 53-73 | |
| » W: Bill Long (8-6) L: Roger Clemens (13-8) S: Scott Nielsen (2) | Seventh | 12½ out |
| Friday, August 28 |
| » Lost to Royals (64-64), 9-3 | Comiskey Park I (23-39) | 53-74 | |
| » W: Charlie Leibrandt (13-9) L: Dave LaPoint (3-3) | Seventh | 12½ out |
| Saturday, August 29 |
| » Defeated Royals (64-65), 7-2 | Comiskey Park I (24-39) | 54-74 | |
| » W: Floyd Bannister (10-10) L: Mark Gubicza (9-15) | Sixth | 12½ out |
| Sunday, August 30 |
| » Lost to Royals (65-65), 11-7 | Comiskey Park I (24-40) | 54-75 | |
| » W: Buddy Black (6-6) L: Richard Dotson (10-11) | Sixth | 13½ out |
| » Major-league debuts: Gary Thurman (Royals) |
| Monday, August 31 |
| » Defeated Royals (65-66), 5-3 | Comiskey Park I (25-40) | 55-75 | |
| » W: Jose DeLeon (8-11) L: Danny Jackson (7-16) S: Bobby Thigpen (7) | Seventh | 13 out |
| Tuesday, September 1 |
| » Lost to Rangers (62-69), 6-4 | Comiskey Park I (25-41) | 55-76 | |
| » W: Jose Guzman (11-11) L: Bill Long (8-7) S: Mitch Williams (5) | Seventh | 13 out |
| Wednesday, September 2 |
| » Defeated Rangers (62-70), 5-0 | Comiskey Park I (26-41) | 56-76 | |
| » W: Dave LaPoint (4-3) L: Paul Kilgus (2-6) | Seventh | 13 out |
| Former White Sox Cam Carreon dies in Tucson, AZ at the age of 51. |
| Thursday, September 3 |
| » Defeated Rangers (62-71), 5-2 | Comiskey Park I (27-41) | 57-76 | Won 2 |
| » W: Floyd Bannister (11-10) L: Bobby Witt (7-8) S: Bobby Thigpen (8) | Seventh | 13 out |
| Friday, September 4 |
| » Lost to Royals (66-69), 6-2 | Royals Stadium (2-2) | 57-77 | |
| » W: Melido Perez (1-0) L: Richard Dotson (10-12) | Sixth | 14 out |
| » Major-league debuts: Melido Perez (Royals) |
| Saturday, September 5 |
| » Lost to Royals (67-69), 4-2 | Royals Stadium (2-3) | 57-78 | Lost 2 |
| » W: Danny Jackson (8-16) L: Jose DeLeon (8-12) | Sixth | 15 out |
| Sunday, September 6 |
| » Defeated Royals (67-70), 5-4 | Royals Stadium (3-3) | 58-78 | |
| » W: Bobby Thigpen (4-4) L: John Davis (3-1) | Sixth | 14 out |
| Monday, September 7 |
| » Lost to Twins (74-65), 8-1 | Hubert H. Humphrey Metrodome (1-3) | 58-79 | |
| » W: Jeff Bittiger (1-0) L: Dave LaPoint (4-4) | Sixth | 15 out |
| Tuesday, September 8 |
| » Defeated Twins (74-66), 4-3 | Hubert H. Humphrey Metrodome (2-3) | 59-79 | |
| » W: Floyd Bannister (12-10) L: Bert Blyleven (13-11) S: Bobby Thigpen (9) | Sixth | 14 out |
| Wednesday, September 9 |
| » Lost to Twins (75-66), 2-1 | Hubert H. Humphrey Metrodome (2-4) | 59-80 | |
| » W: Frank Viola (15-8) L: Jim Winn (4-6) | Seventh | 15 out |
| Friday, September 11 |
| » Defeated Mariners (66-74), 5-1 | Kingdome (1-3) | 60-80 | |
| » W: Jose DeLeon (9-12) L: Mike Campbell (0-4) S: Bobby Thigpen (10) | Seventh | 15 out |
| Saturday, September 12 |
| » Lost to Mariners (67-74), 12-2 | Kingdome (1-4) | 60-81 | |
| » W: Scott Bankhead (9-8) L: Bill Long (8-8) | Seventh | 15 out |
| » Major-league debuts: Mario Diaz and Edgar Martinez (Mariners) |
| Sunday, September 13 |
| » Defeated Mariners (67-75), 2-0 | Kingdome (2-4) | 61-81 | |
| » W: Floyd Bannister (13-10) L: Mark Langston (17-11) | Fifth | 15 out |
| Monday, September 14 |
| » Defeated Twins (77-68), 8-2 | Comiskey Park I (28-41) | 62-81 | Won 2 |
| » W: Dave LaPoint (5-4) L: Frank Viola (15-9) | Seventh | 14 out |
| Tuesday, September 15 |
| » Defeated Twins (77-69), 6-2 | Comiskey Park I (29-41) | 63-81 | Won 3 |
| » W: Jack McDowell (1-0) L: Joe Niekro (6-12) | Fifth | 13 out |
| » Major-league debuts: Jack McDowell (White Sox) |
| Wednesday, September 16 |
| » Defeated Twins (77-70), 13-10 | Comiskey Park I (30-41) | 64-81 | Won 4 |
| » W: Jose DeLeon (10-12) L: Mike Smithson (4-7) S: Bobby Thigpen (11) | Fifth | 12 out |
| Thursday, September 17 |
| » Defeated Mariners (68-78), 9-8 | Comiskey Park I (31-41) | 65-81 | Won 5 |
| » W: Bobby Thigpen (5-4) L: Bill Wilkinson (3-4) | Seventh | 11½ out |
| Friday, September 18 |
| » Lost to Mariners (69-78), 1-0 | Comiskey Park I (31-42) | 65-82 | |
| » W: Mark Langston (18-11) L: Floyd Bannister (13-11) | Seventh | 12½ out |
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