| Monday, April 6 |
| » Major-league debuts: Mike Sharperson (Blue Jays) |
| Tuesday, April 7 |
| » Defeated Athletics (0-1), 5-4 | Hubert H. Humphrey Metrodome (1-0) | 1-0 | |
| » W: George Frazier (1-0) L: Bill Krueger (0-1) | First | -- |
| Wednesday, April 8 |
| » Defeated Athletics (0-2), 4-1 | Hubert H. Humphrey Metrodome (2-0) | 2-0 | Won 2 |
| » W: Frank Viola (1-0) L: Eric Plunk (0-1) S: Jeff Reardon (1) | First | -- |
| Thursday, April 9 |
| » Defeated Athletics (0-3), 5-4 | Hubert H. Humphrey Metrodome (3-0) | 3-0 | Won 3 |
| » W: Juan Berenguer (1-0) L: Jay Howell (0-1) | First | -- |
| » Major-league debuts: Joe Klink (Twins) |
| Friday, April 10 |
| » Defeated Mariners (1-3), 8-1 | Kingdome (1-0) | 4-0 | Won 4 |
| » W: Mike Smithson (1-0) L: Mike Morgan (0-1) | First | -- |
| Saturday, April 11 |
| » Lost to Mariners (2-3), 6-5 | Kingdome (1-1) | 4-1 | |
| » W: Ed Nunez (1-0) L: Jeff Reardon (0-1) | First | -- |
| » Major-league debuts: Les Straker (Twins) |
| Sunday, April 12 |
| » Defeated Mariners (2-4), 8-5 | Kingdome (2-1) | 5-1 | |
| » W: Bert Blyleven (1-0) L: Mark Langston (0-2) S: Juan Berenguer (1) | First | -- |
| Monday, April 13 |
| » Lost to Athletics (2-5), 6-3 | Oakland-Alameda County Stadium (0-1) | 5-2 | |
| » W: Jay Howell (1-1) L: George Frazier (1-1) | First | -- |
| Tuesday, April 14 |
| » Defeated Athletics (2-6), 9-8 | Oakland-Alameda County Stadium (1-1) | 6-2 | |
| » W: Keith Atherton (1-0) L: Chris Codiroli (0-1) S: Jeff Reardon (2) | First | -- |
| Wednesday, April 15 |
| » Defeated Athletics (2-7), 5-2 | Oakland-Alameda County Stadium (2-1) | 7-2 | Won 2 |
| » W: Mike Smithson (2-0) L: Dave Stewart (0-2) S: Jeff Reardon (3) | First | -- |
| Friday, April 17 |
| » Lost to Angels (7-3), 2-1 | Anaheim Stadium (0-1) | 7-3 | |
| » W: Mike Witt (2-1) L: Bert Blyleven (1-1) | First | -- |
| Saturday, April 18 |
| » Lost to Angels (8-3), 1-0 | Anaheim Stadium (0-2) | 7-4 | Lost 2 |
| » W: John Candelaria (2-0) L: Frank Viola (1-1) S: Donnie Moore (2) | Second | 1 out |
| Sunday, April 19 |
| » Defeated Angels (8-4), 6-5 | Anaheim Stadium (1-2) | 8-4 | |
| » W: Mark Portugal (1-0) L: Don Sutton (0-3) S: Jeff Reardon (4) | First | -- |
| Monday, April 20 |
| » Defeated Mariners (6-8), 13-5 | Hubert H. Humphrey Metrodome (4-0) | 9-4 | Won 2 |
| » W: Mike Smithson (3-0) L: Mike Morgan (0-3) | First | -- |
| Tuesday, April 21 |
| » Defeated Mariners (6-9), 6-1 | Hubert H. Humphrey Metrodome (5-0) | 10-4 | Won 3 |
| » W: Les Straker (1-0) L: Mike Trujillo (1-1) | First | -- |
| Wednesday, April 22 |
| » Lost to Mariners (7-9), 4-3 | Hubert H. Humphrey Metrodome (5-1) | 10-5 | |
| » W: Mark Langston (2-2) L: George Frazier (1-2) | First | -- |
| Thursday, April 23 |
| » Lost to Angels (10-6), 7-3 | Hubert H. Humphrey Metrodome (5-2) | 10-6 | Lost 2 |
| » W: John Candelaria (3-0) L: Frank Viola (1-2) S: Donnie Moore (3) | First | -- |
| Friday, April 24 |
| » Lost to Angels (11-6), 8-1 | Hubert H. Humphrey Metrodome (5-3) | 10-7 | Lost 3 |
| » W: Don Sutton (1-3) L: Mark Portugal (1-1) | Second | 1 out |
| Saturday, April 25 |
| » Defeated Angels (11-7), 8-7 | Hubert H. Humphrey Metrodome (6-3) | 11-7 | |
| » W: Jeff Reardon (1-1) L: Chuck Finley (0-1) | First | -- |
| » Major-league debuts: DeWayne Buice (Angels) |
| Sunday, April 26 |
| » Defeated Angels (11-8), 10-5 | Hubert H. Humphrey Metrodome (7-3) | 12-7 | Won 2 |
| » W: George Frazier (2-2) L: Mike Cook (1-1) | First | -- |
| Tuesday, April 28 |
| » Lost to Blue Jays (11-8), 5-1 | Exhibition Stadium (0-1) | 12-8 | |
| » W: Jim Clancy (2-2) L: Frank Viola (1-3) | First | -- |
| Wednesday, April 29 |
| » Lost to Blue Jays (12-8), 8-1 | Exhibition Stadium (0-2) | 12-9 | Lost 2 |
| » W: Joe Johnson (1-2) L: Mike Smithson (3-1) | First | -- |
| Thursday, April 30 |
| » Major-league debuts: Ellis Burks (Red Sox) |
| Friday, May 1 |
| » Defeated Yankees (14-8), 7-4 | Hubert H. Humphrey Metrodome (8-3) | 13-9 | |
| » W: Bert Blyleven (2-1) L: Rick Rhoden (2-3) S: Jeff Reardon (5) | First | -- |
| Saturday, May 2 |
| » Lost to Yankees (15-8), 6-4 | Hubert H. Humphrey Metrodome (8-4) | 13-10 | |
| » W: Tommy John (2-0) L: Frank Viola (1-4) S: Dave Righetti (7) | First | -- |
| Sunday, May 3 |
| » Defeated Yankees (15-9), 4-3 | Hubert H. Humphrey Metrodome (9-4) | 14-10 | |
| » W: George Frazier (3-2) L: Tim Stoddard (0-1) S: Jeff Reardon (6) | First | -- |
| Tuesday, May 5 |
| » Lost to Orioles (10-15), 5-4 | Hubert H. Humphrey Metrodome (9-5) | 14-11 | |
| » W: Eric Bell (3-1) L: Mike Smithson (3-2) S: Ken Dixon (1) | First | -- |
| Wednesday, May 6 |
| » Lost to Orioles (11-15), 6-0 | Hubert H. Humphrey Metrodome (9-6) | 14-12 | Lost 2 |
| » W: Scott McGregor (1-4) L: Bert Blyleven (2-2) | Third | 1 out |
| Thursday, May 7 |
| » Defeated Orioles (11-16), 5-2 | Hubert H. Humphrey Metrodome (10-6) | 15-12 | |
| » W: Frank Viola (2-4) L: Mike Flanagan (0-5) S: Jeff Reardon (7) | Second | ½ out |
| Friday, May 8 |
| » Lost to Yankees (18-10), 11-7 | Yankee Stadium (0-1) | 15-13 | |
| » W: Cecilio Guante (2-1) L: Jeff Reardon (1-2) | Third | 1½ out |
| Saturday, May 9 |
| » Defeated Yankees (18-11), 2-0 | Yankee Stadium (1-1) | 16-13 | |
| » W: Les Straker (2-0) L: Dennis Rasmussen (2-2) S: Jeff Reardon (8) | Third | 1½ out |
| Sunday, May 10 |
| » Lost to Yankees (19-11), 6-1 | Yankee Stadium (1-2) | 16-14 | |
| » W: Charles Hudson (5-0) L: Mike Smithson (3-3) | Third | 1½ out |
| Monday, May 11 |
| » Defeated Orioles (14-17), 10-4 | Memorial Stadium (1-0) | 17-14 | |
| » W: Bert Blyleven (3-2) L: Scott McGregor (1-5) | Second | ½ out |
| Tuesday, May 12 |
| » Lost to Orioles (15-17), 10-7 | Memorial Stadium (1-1) | 17-15 | |
| » W: Ken Dixon (3-2) L: Jeff Reardon (1-3) | Third | 1½ out |
| Wednesday, May 13 |
| » Lost to Blue Jays (19-12), 7-0 | Hubert H. Humphrey Metrodome (10-7) | 17-16 | Lost 2 |
| » W: Jim Clancy (5-2) L: Mark Portugal (1-2) | Fourth | 1½ out |
| Thursday, May 14 |
| » Lost to Blue Jays (20-12), 16-4 | Hubert H. Humphrey Metrodome (10-8) | 17-17 | Lost 3 |
| » W: Dave Stieb (2-2) L: Les Straker (2-1) | Fourth | 2 out |
| Friday, May 15 |
| » Defeated Red Sox (15-19), 3-1 | Hubert H. Humphrey Metrodome (11-8) | 18-17 | |
| » W: George Frazier (4-2) L: Bruce Hurst (4-4) | Third | 1½ out |
| Saturday, May 16 |
| » Lost to Red Sox (16-19), 6-1 | Hubert H. Humphrey Metrodome (11-9) | 18-18 | |
| » W: Roger Clemens (3-3) L: Bert Blyleven (3-3) | Fourth | 2½ out |
| Sunday, May 17 |
| » Defeated Red Sox (16-20), 10-8 | Hubert H. Humphrey Metrodome (12-9) | 19-18 | |
| » W: Keith Atherton (2-0) L: Calvin Schiraldi (1-3) | Third | 2½ out |
| » Major-league debuts: Tom Bolton (Red Sox) |
| Tuesday, May 19 |
| » Lost to Indians (12-26), 4-3 | Cleveland Stadium (0-1) | 19-19 | |
| » W: Ken Schrom (3-4) L: Mark Portugal (1-3) | Third | 4 out |
| Wednesday, May 20 |
| » Defeated Indians (12-27), 8-2 | Cleveland Stadium (1-1) | 20-19 | |
| » W: Juan Berenguer (2-0) L: Tom Candiotti (1-6) | Third | 3 out |
| Thursday, May 21 |
| » Lost to Indians (13-27), 6-3 | Cleveland Stadium (1-2) | 20-20 | |
| » W: Greg Swindell (3-3) L: Bert Blyleven (3-4) | Fourth | 3½ out |
| » Major-league debuts: Gene Larkin (Twins) |
| Friday, May 22 |
| » Lost to Tigers (19-20), 3-2 | Hubert H. Humphrey Metrodome (12-10) | 20-21 | Lost 2 |
| » W: Jack Morris (5-2) L: Frank Viola (2-5) S: Eric King (2) | Fourth | 4½ out |
| Saturday, May 23 |
| » Defeated Tigers (19-21), 7-5 | Hubert H. Humphrey Metrodome (13-10) | 21-21 | |
| » W: Allan Anderson (1-0) L: Walt Terrell (3-5) S: Jeff Reardon (9) | Second | 3½ out |
| Sunday, May 24 |
| » Lost to Tigers (20-21), 7-2 | Hubert H. Humphrey Metrodome (13-11) | 21-22 | |
| » W: Jeff Robinson (3-2) L: Keith Atherton (2-1) | Third | 4½ out |
| Tuesday, May 26 |
| » Defeated Brewers (22-18), 4-2 | Hubert H. Humphrey Metrodome (14-11) | 22-22 | |
| » W: Bert Blyleven (4-4) L: Juan Nieves (3-2) S: Jeff Reardon (10) | Second | 5 out |
| Wednesday, May 27 |
| » Defeated Brewers (22-19), 7-2 | Hubert H. Humphrey Metrodome (15-11) | 23-22 | Won 2 |
| » W: Frank Viola (3-5) L: Bill Wegman (3-5) S: George Frazier (1) | Second | 4 out |
| Thursday, May 28 |
| » Defeated Brewers (22-20), 13-1 | Hubert H. Humphrey Metrodome (16-11) | 24-22 | Won 3 |
| » W: Juan Berenguer (3-0) L: Mike Birkbeck (1-4) | Second | 3½ out |
| Friday, May 29 |
| » Lost to Tigers (24-21), 15-7 | Tiger Stadium (0-1) | 24-23 | |
| » W: Walt Terrell (4-5) L: Les Straker (2-2) | Second | 3½ out |
| Sunday, May 31 |
| » Defeated Tigers (24-22), 9-5 | Tiger Stadium (1-1) | 25-23 | |
| » W: Jeff Reardon (2-3) L: Eric King (2-4) | Second | 2½ out |
| » Defeated Tigers (24-23), 11-3 | Tiger Stadium (2-1) | 26-23 | Won 2 |
| » W: George Frazier (5-2) L: Frank Tanana (4-3) | Second | 2½ out |
| Monday, June 1 |
| » Defeated Red Sox (22-28), 9-5 | Fenway Park (1-0) | 27-23 | Won 3 |
| » W: Frank Viola (4-5) L: Roger Clemens (4-5) | Second | 1½ out |
| Tuesday, June 2 |
| » Lost to Red Sox (23-28), 6-5 | Fenway Park (1-1) | 27-24 | |
| » W: Calvin Schiraldi (3-3) L: Jeff Reardon (2-4) | Second | 1½ out |
| Wednesday, June 3 |
| » Lost to Red Sox (24-28), 7-6 | Fenway Park (1-2) | 27-25 | Lost 2 |
| » W: Calvin Schiraldi (4-3) L: Joe Klink (0-1) | Second | 1½ out |
| Friday, June 5 |
| » Lost to Rangers (22-28), 15-9 | Hubert H. Humphrey Metrodome (16-12) | 27-26 | Lost 3 |
| » W: Greg Harris (2-4) L: Bert Blyleven (4-5) | Third | 2 out |
| Saturday, June 6 |
| » Defeated Rangers (22-29), 3-2 | Hubert H. Humphrey Metrodome (17-12) | 28-26 | |
| » W: Keith Atherton (3-1) L: Mitch Williams (3-3) | Second | 2 out |
| Sunday, June 7 |
| » Defeated Rangers (22-30), 7-4 | Hubert H. Humphrey Metrodome (18-12) | 29-26 | Won 2 |
| » W: Keith Atherton (4-1) L: Jeff Russell (0-1) | Second | 2 out |
| » Major-league debuts: Paul Kilgus (Rangers) |
| Monday, June 8 |
| » Defeated Royals (30-24), 5-3 | Hubert H. Humphrey Metrodome (19-12) | 30-26 | Won 3 |
| » W: Randy Niemann (1-0) L: Mark Gubicza (3-7) S: Jeff Reardon (11) | Second | 1 out |
| Tuesday, June 9 |
| » Defeated Royals (30-25), 5-2 | Hubert H. Humphrey Metrodome (20-12) | 31-26 | Won 4 |
| » W: Joe Niekro (4-4) L: Danny Jackson (2-8) S: Keith Atherton (1) | Second | 1 out |
| Wednesday, June 10 |
| » Defeated Royals (30-26), 4-3 | Hubert H. Humphrey Metrodome (21-12) | 32-26 | Won 5 |
| » W: Jeff Reardon (3-4) L: Jerry Gleaton (1-2) | First | -- |
| Friday, June 12 |
| » Defeated White Sox (22-34), 5-2 | Comiskey Park I (1-0) | 33-26 | Won 6 |
| » W: Frank Viola (5-5) L: Bill Long (3-2) S: Jeff Reardon (12) | First | -- |
| » Defeated White Sox (22-35), 7-4 | Comiskey Park I (2-0) | 34-26 | Won 7 |
| » W: Juan Berenguer (4-0) L: Scott Nielsen (0-1) S: Keith Atherton (2) | First | -- |
| Saturday, June 13 |
| » Lost to White Sox (23-35), 6-2 | Comiskey Park I (2-1) | 34-27 | |
| » W: Richard Dotson (4-4) L: Les Straker (2-3) S: Bob James (8) | First | -- |
| Sunday, June 14 |
| » Defeated White Sox (23-36), 6-3 | Comiskey Park I (3-1) | 35-27 | |
| » W: Joe Niekro (5-4) L: Jose DeLeon (4-6) S: Juan Berenguer (2) | First | -- |
| Monday, June 15 |
| » Defeated Brewers (32-27), 5-0 | County Stadium (1-0) | 36-27 | Won 2 |
| » W: Bert Blyleven (5-5) L: Bill Wegman (5-6) | First | -- |
| Tuesday, June 16 |
| » Defeated Brewers (32-28), 7-3 | County Stadium (2-0) | 37-27 | Won 3 |
| » W: Frank Viola (6-5) L: Chuck Crim (3-4) S: Jeff Reardon (13) | First | -- |
| Wednesday, June 17 |
| » Lost to Brewers (33-28), 8-5 | County Stadium (2-1) | 37-28 | |
| » W: Mark Clear (5-1) L: Les Straker (2-4) S: Dan Plesac (14) | First | -- |
| Friday, June 19 |
| » Defeated White Sox (23-40), 7-6 | Hubert H. Humphrey Metrodome (22-12) | 38-28 | |
| » W: Jeff Reardon (4-4) L: Jim Winn (2-3) | First | -- |
| Saturday, June 20 |
| » Lost to White Sox (24-40), 10-5 | Hubert H. Humphrey Metrodome (22-13) | 38-29 | |
| » W: Jose DeLeon (5-6) L: Bert Blyleven (5-6) | First | -- |
| Sunday, June 21 |
| » Defeated White Sox (24-41), 8-6 | Hubert H. Humphrey Metrodome (23-13) | 39-29 | |
| » W: Juan Berenguer (5-0) L: Jim Winn (2-4) S: Jeff Reardon (14) | First | -- |
| Tuesday, June 23 |
| » Defeated Indians (25-43), 9-4 | Hubert H. Humphrey Metrodome (24-13) | 40-29 | Won 2 |
| » W: Mike Smithson (4-3) L: Tom Candiotti (2-8) S: George Frazier (2) | First | -- |
| Wednesday, June 24 |
| » Defeated Indians (25-44), 14-8 | Hubert H. Humphrey Metrodome (25-13) | 41-29 | Won 3 |
| » W: Les Straker (3-4) L: Greg Swindell (3-7) | First | -- |
| Thursday, June 25 |
| » Defeated Indians (25-45), 4-3 | Hubert H. Humphrey Metrodome (26-13) | 42-29 | Won 4 |
| » W: Bert Blyleven (6-6) L: Phil Niekro (5-7) S: Jeff Reardon (15) | First | -- |
| Friday, June 26 |
| » Lost to Rangers (31-38), 1-0 | Arlington Stadium (0-1) | 42-30 | |
| » W: Bobby Witt (3-3) L: Frank Viola (6-6) S: Dale Mohorcic (10) | First | -- |
| Saturday, June 27 |
| » Lost to Rangers (32-38), 11-6 | Arlington Stadium (0-2) | 42-31 | Lost 2 |
| » W: Ed Correa (3-5) L: George Frazier (5-3) S: Jeff Russell (2) | First | -- |
| » Lost to Rangers (33-38), 7-2 | Arlington Stadium (0-3) | 42-32 | Lost 3 |
| » W: Charlie Hough (8-3) L: Keith Atherton (4-2) | First | -- |
| Sunday, June 28 |
| » Lost to Rangers (34-38), 6-3 | Arlington Stadium (0-4) | 42-33 | Lost 4 |
| » W: Jose Guzman (6-6) L: Mike Smithson (4-4) S: Dale Mohorcic (11) | First | -- |
| Monday, June 29 |
| » Lost to Royals (39-34), 3-2 | Royals Stadium (0-1) | 42-34 | Lost 5 |
| » W: Danny Jackson (4-10) L: Les Straker (3-5) | First | -- |
| Tuesday, June 30 |
| » Defeated Royals (39-35), 3-1 | Royals Stadium (1-1) | 43-34 | |
| » W: Bert Blyleven (7-6) L: Charlie Leibrandt (8-6) S: Jeff Reardon (16) | First | -- |
| Wednesday, July 1 |
| » Lost to Royals (40-35), 4-3 | Royals Stadium (1-2) | 43-35 | |
| » W: Dan Quisenberry (3-0) L: Keith Atherton (4-3) | First | -- |
| Thursday, July 2 |
| » Lost to Royals (41-35), 10-3 | Royals Stadium (1-3) | 43-36 | Lost 2 |
| » W: Bret Saberhagen (14-2) L: Joe Niekro (5-5) | First | -- |
| Friday, July 3 |
| » Defeated Orioles (31-48), 6-5 | Hubert H. Humphrey Metrodome (27-13) | 44-36 | |
| » W: Jeff Reardon (5-4) L: Tom Niedenfuer (2-1) | Second | 1 out |
| Saturday, July 4 |
| » Defeated Orioles (31-49), 4-1 | Hubert H. Humphrey Metrodome (28-13) | 45-36 | Won 2 |
| » W: Les Straker (4-5) L: Eric Bell (6-6) S: Juan Berenguer (3) | Second | 1 out |
| Sunday, July 5 |
| » Defeated Orioles (31-50), 4-3 | Hubert H. Humphrey Metrodome (29-13) | 46-36 | Won 3 |
| » W: Bert Blyleven (8-6) L: Tom Niedenfuer (2-2) | Second | 1 out |
| Monday, July 6 |
| » Defeated Yankees (51-32), 2-0 | Yankee Stadium (2-2) | 47-36 | Won 4 |
| » W: Frank Viola (7-6) L: Ron Guidry (1-4) | First | -- |
| Tuesday, July 7 |
| » Lost to Yankees (52-32), 12-7 | Yankee Stadium (2-3) | 47-37 | |
| » W: Tim Stoddard (2-1) L: Keith Atherton (4-4) | First | -- |
| Wednesday, July 8 |
| » Lost to Yankees (53-32), 13-4 | Yankee Stadium (2-4) | 47-38 | Lost 2 |
| » W: Rick Rhoden (11-5) L: Mike Smithson (4-5) S: Pat Clements (4) | First | -- |
| Thursday, July 9 |
| » Defeated Orioles (33-52), 3-1 | Memorial Stadium (2-1) | 48-38 | |
| » W: Les Straker (5-5) L: Eric Bell (6-7) S: Jeff Reardon (17) | First | -- |
| Friday, July 10 |
| » Lost to Orioles (34-52), 13-12 | Memorial Stadium (2-2) | 48-39 | |
| » W: Mark Williamson (3-6) L: George Frazier (5-4) | First | -- |
| Saturday, July 11 |
| » Defeated Orioles (34-53), 2-1 | Memorial Stadium (3-2) | 49-39 | |
| » W: Frank Viola (8-6) L: Mike Griffin (1-3) | First | -- |
| » Major-league debuts: Billy Ripken (Orioles) |
| Sunday, July 12 |
| » Lost to Orioles (35-53), 5-0 | Memorial Stadium (3-3) | 49-40 | |
| » W: Dave J. Schmidt (9-2) L: Joe Niekro (5-6) | First | -- |
| Thursday, July 16 |
| » Lost to Blue Jays (52-36), 5-2 | Hubert H. Humphrey Metrodome (29-14) | 49-41 | Lost 2 |
| » W: Jimmy Key (10-6) L: Bert Blyleven (8-7) S: Tom Henke (18) | First | -- |
| Friday, July 17 |
| » Defeated Blue Jays (52-37), 3-2 | Hubert H. Humphrey Metrodome (30-14) | 50-41 | |
| » W: Frank Viola (9-6) L: Mark Eichhorn (8-5) S: Jeff Reardon (18) | First | -- |
| Saturday, July 18 |
| » Lost to Blue Jays (53-37), 7-5 | Hubert H. Humphrey Metrodome (30-15) | 50-42 | |
| » W: Dave Stieb (8-5) L: Joe Niekro (5-7) | First | -- |
| Sunday, July 19 |
| » Defeated Blue Jays (53-38), 7-6 | Hubert H. Humphrey Metrodome (31-15) | 51-42 | |
| » W: Dan Schatzeder (4-1) L: Gary Lavelle (1-1) S: Jeff Reardon (19) | First | -- |
| Monday, July 20 |
| » Lost to Yankees (58-36), 7-1 | Hubert H. Humphrey Metrodome (31-16) | 51-43 | |
| » W: Tommy John (9-3) L: Les Straker (5-6) | First | -- |
| Tuesday, July 21 |
| » Defeated Yankees (58-37), 2-1 | Hubert H. Humphrey Metrodome (32-16) | 52-43 | |
| » W: Bert Blyleven (9-7) L: Tim Stoddard (2-2) | First | -- |
| Wednesday, July 22 |
| » Defeated Yankees (58-38), 3-1 | Hubert H. Humphrey Metrodome (33-16) | 53-43 | Won 2 |
| » W: Frank Viola (10-6) L: Rick Rhoden (12-6) S: Jeff Reardon (20) | First | -- |
| Thursday, July 23 |
| » Lost to Blue Jays (55-40), 4-3 | Exhibition Stadium (0-3) | 53-44 | |
| » W: Dave Stieb (9-5) L: George Frazier (5-5) | First | -- |
| Friday, July 24 |
| » Lost to Blue Jays (56-40), 8-6 | Exhibition Stadium (0-4) | 53-45 | Lost 2 |
| » W: Mark Eichhorn (9-5) L: Jeff Reardon (5-5) S: Tom Henke (20) | First | -- |
| Saturday, July 25 |
| » Defeated Blue Jays (56-41), 13-9 | Exhibition Stadium (1-4) | 54-45 | |
| » W: Dan Schatzeder (5-1) L: Jeff Musselman (7-4) | First | -- |
| Sunday, July 26 |
| » Lost to Blue Jays (57-41), 4-2 | Exhibition Stadium (1-5) | 54-46 | |
| » W: Jimmy Key (11-6) L: Bert Blyleven (9-8) S: Tom Henke (21) | First | -- |
| Monday, July 27 |
| » Defeated Mariners (47-52), 4-3 | Kingdome (3-1) | 55-46 | |
| » W: Frank Viola (11-6) L: Ed Nunez (3-2) S: Jeff Reardon (21) | First | -- |
| Tuesday, July 28 |
| » Lost to Mariners (48-52), 6-1 | Kingdome (3-2) | 55-47 | |
| » W: Mike Morgan (8-11) L: Joe Niekro (5-8) | First | -- |
| Wednesday, July 29 |
| » Lost to Mariners (49-52), 8-3 | Kingdome (3-3) | 55-48 | Lost 2 |
| » W: Lee Guetterman (9-2) L: Mike Smithson (4-6) | First | -- |
| Friday, July 31 |
| » Defeated Athletics (52-50), 5-3 | Oakland-Alameda County Stadium (3-1) | 56-48 | |
| » W: Bert Blyleven (10-8) L: Dennis Lamp (1-2) S: Jeff Reardon (22) | First | -- |
| Saturday, August 1 |
| » Lost to Athletics (53-50), 3-2 | Oakland-Alameda County Stadium (3-2) | 56-49 | |
| » W: Dave Stewart (14-7) L: Frank Viola (11-7) | First | -- |
| Sunday, August 2 |
| » Lost to Athletics (54-50), 6-5 | Oakland-Alameda County Stadium (3-3) | 56-50 | Lost 2 |
| » W: Gene Nelson (5-2) L: Jeff Reardon (5-6) | First | -- |
| Monday, August 3 |
| » Defeated Angels (54-52), 11-3 | Anaheim Stadium (2-2) | 57-50 | |
| » W: Dan Schatzeder (6-1) L: Mike Witt (13-7) | First | -- |
| Tuesday, August 4 |
| » Lost to Angels (55-52), 12-3 | Anaheim Stadium (2-3) | 57-51 | |
| » W: Don Sutton (8-9) L: Steve Carlton (5-10) S: Gary Lucas (2) | First | -- |
| Wednesday, August 5 |
| » Lost to Angels (56-52), 6-1 | Anaheim Stadium (2-4) | 57-52 | Lost 2 |
| » W: John Candelaria (6-3) L: Bert Blyleven (10-9) | First | -- |
| Thursday, August 6 |
| » Defeated Athletics (56-52), 9-4 | Hubert H. Humphrey Metrodome (34-16) | 58-52 | |
| » W: Frank Viola (12-7) L: Dave Stewart (14-8) | First | -- |
| Friday, August 7 |
| » Defeated Athletics (56-53), 9-4 | Hubert H. Humphrey Metrodome (35-16) | 59-52 | Won 2 |
| » W: Joe Niekro (6-8) L: Dennis Lamp (1-3) | First | -- |
| Saturday, August 8 |
| » Defeated Athletics (56-54), 9-2 | Hubert H. Humphrey Metrodome (36-16) | 60-52 | Won 3 |
| » W: Steve Carlton (6-10) L: Curt Young (10-6) | First | -- |
| Sunday, August 9 |
| » Defeated Athletics (56-55), 7-5 | Hubert H. Humphrey Metrodome (37-16) | 61-52 | Won 4 |
| » W: Bert Blyleven (11-9) L: Steve Ontiveros (6-6) S: Jeff Reardon (23) | First | -- |
| Tuesday, August 11 |
| » Defeated Angels (57-56), 7-2 | Hubert H. Humphrey Metrodome (38-16) | 62-52 | Won 5 |
| » W: Frank Viola (13-7) L: John Candelaria (6-4) | First | -- |
| Wednesday, August 12 |
| » Lost to Angels (58-56), 8-2 | Hubert H. Humphrey Metrodome (38-17) | 62-53 | |
| » W: Kirk McCaskill (3-4) L: Les Straker (5-7) | First | -- |
| Thursday, August 13 |
| » Lost to Angels (59-56), 5-1 | Hubert H. Humphrey Metrodome (38-18) | 62-54 | Lost 2 |
| » W: Mike Witt (14-8) L: Steve Carlton (6-11) | First | -- |
| Friday, August 14 |
| » Defeated Mariners (56-59), 6-3 | Hubert H. Humphrey Metrodome (39-18) | 63-54 | |
| » W: Bert Blyleven (12-9) L: Mike Morgan (10-12) | First | -- |
| Saturday, August 15 |
| » Defeated Mariners (56-60), 14-4 | Hubert H. Humphrey Metrodome (40-18) | 64-54 | Won 2 |
| » W: Roy Smith (1-0) L: Lee Guetterman (9-4) | First | -- |
| Sunday, August 16 |
| » Defeated Mariners (56-61), 5-1 | Hubert H. Humphrey Metrodome (41-18) | 65-54 | Won 3 |
| » W: Frank Viola (14-7) L: Mike Moore (5-15) | First | -- |
| Monday, August 17 |
| » Defeated Mariners (56-62), 4-2 | Hubert H. Humphrey Metrodome (42-18) | 66-54 | Won 4 |
| » W: Les Straker (6-7) L: Mark Langston (13-10) S: Jeff Reardon (24) | First | -- |
| Tuesday, August 18 |
| » Lost to Tigers (69-47), 11-2 | Tiger Stadium (2-2) | 66-55 | |
| » W: Jack Morris (14-6) L: Steve Carlton (6-12) | First | -- |
| Wednesday, August 19 |
| » Lost to Tigers (70-47), 7-1 | Tiger Stadium (2-3) | 66-56 | Lost 2 |
| » W: Walt Terrell (10-10) L: Bert Blyleven (12-10) | First | -- |
| Thursday, August 20 |
| » Lost to Tigers (71-47), 8-0 | Tiger Stadium (2-4) | 66-57 | Lost 3 |
| » W: Doyle Alexander (6-10) L: Joe Niekro (6-9) | First | -- |
| Friday, August 21 |
| » Lost to Red Sox (58-63), 11-3 | Fenway Park (1-3) | 66-58 | Lost 4 |
| » W: Roger Clemens (13-7) L: Frank Viola (14-8) S: Wes Gardner (5) | First | -- |
| Saturday, August 22 |
| » Lost to Red Sox (59-63), 6-5 | Fenway Park (1-4) | 66-59 | Lost 5 |
| » W: Calvin Schiraldi (8-5) L: Les Straker (6-8) | First | -- |
| Sunday, August 23 |
| » Lost to Red Sox (60-63), 6-4 | Fenway Park (1-5) | 66-60 | Lost 6 |
| » W: Jeff Sellers (5-6) L: Steve Carlton (6-13) S: Wes Gardner (6) | First | -- |
| Monday, August 24 |
| » Defeated Tigers (73-50), 5-4 | Hubert H. Humphrey Metrodome (43-18) | 67-60 | |
| » W: Jeff Reardon (6-6) L: Eric King (6-9) | First | -- |
| Tuesday, August 25 |
| » Lost to Tigers (74-50), 5-4 | Hubert H. Humphrey Metrodome (43-19) | 67-61 | |
| » W: Doyle Alexander (7-10) L: Joe Niekro (6-10) S: Mike Henneman (4) | First | -- |
| Wednesday, August 26 |
| » Lost to Tigers (75-50), 10-8 | Hubert H. Humphrey Metrodome (43-20) | 67-62 | Lost 2 |
| » W: Dan Petry (8-6) L: Jeff Reardon (6-7) S: Guillermo Hernandez (7) | First | -- |
| Friday, August 28 |
| » Lost to Brewers (70-58), 1-0 | County Stadium (2-2) | 67-63 | Lost 3 |
| » W: Chris Bosio (8-5) L: Les Straker (6-9) | Second | 1 out |
| Saturday, August 29 |
| » Defeated Brewers (70-59), 12-3 | County Stadium (3-2) | 68-63 | |
| » W: Bert Blyleven (13-10) L: Len Barker (2-1) | First | -- |
| Sunday, August 30 |
| » Defeated Brewers (70-60), 10-6 | County Stadium (4-2) | 69-63 | Won 2 |
| » W: Keith Atherton (5-4) L: Chuck Crim (5-6) S: Jeff Reardon (25) | First | -- |
| Tuesday, September 1 |
| » Lost to Red Sox (63-67), 9-0 | Hubert H. Humphrey Metrodome (43-21) | 69-64 | |
| » W: Jeff Sellers (6-6) L: Joe Niekro (6-11) | First | -- |
| Wednesday, September 2 |
| » Defeated Red Sox (63-68), 5-4 | Hubert H. Humphrey Metrodome (44-21) | 70-64 | |
| » W: Les Straker (7-9) L: Al Nipper (8-11) S: Jeff Reardon (26) | First | -- |
| Thursday, September 3 |
| » Defeated Red Sox (63-69), 2-1 | Hubert H. Humphrey Metrodome (45-21) | 71-64 | Won 2 |
| » W: Keith Atherton (6-4) L: Wes Gardner (1-6) | First | -- |
| Friday, September 4 |
| » Defeated Brewers (73-61), 2-1 | Hubert H. Humphrey Metrodome (46-21) | 72-64 | Won 3 |
| » W: Juan Berenguer (6-0) L: Dan Plesac (5-5) | First | -- |
| Saturday, September 5 |
| » Defeated Brewers (73-62), 2-1 | Hubert H. Humphrey Metrodome (47-21) | 73-64 | Won 4 |
| » W: Keith Atherton (7-4) L: Chuck Crim (5-7) | First | -- |
| Sunday, September 6 |
| » Lost to Brewers (74-62), 6-0 | Hubert H. Humphrey Metrodome (47-22) | 73-65 | |
| » W: Teddy Higuera (15-9) L: Steve Carlton (6-14) | First | -- |
| Monday, September 7 |
| » Defeated White Sox (58-79), 8-1 | Hubert H. Humphrey Metrodome (48-22) | 74-65 | |
| » W: Jeff Bittiger (1-0) L: Dave LaPoint (4-4) | First | -- |
| Tuesday, September 8 |
| » Lost to White Sox (59-79), 4-3 | Hubert H. Humphrey Metrodome (48-23) | 74-66 | |
| » W: Floyd Bannister (12-10) L: Bert Blyleven (13-11) S: Bobby Thigpen (9) | First | -- |
| Wednesday, September 9 |
| » Defeated White Sox (59-80), 2-1 | Hubert H. Humphrey Metrodome (49-23) | 75-66 | |
| » W: Frank Viola (15-8) L: Jim Winn (4-6) | First | -- |
| Friday, September 11 |
| » Defeated Indians (53-89), 13-10 | Cleveland Stadium (2-2) | 76-66 | Won 2 |
| » W: Jeff Reardon (7-7) L: Don Gordon (0-3) S: Juan Berenguer (4) | First | -- |
| Saturday, September 12 |
| » Lost to Indians (54-89), 5-4 | Cleveland Stadium (2-3) | 76-67 | |
| » W: Doug Jones (4-4) L: Juan Berenguer (6-1) | First | -- |
| Sunday, September 13 |
| » Defeated Indians (54-90), 7-3 | Cleveland Stadium (3-3) | 77-67 | |
| » W: Jeff Reardon (8-7) L: Tom Candiotti (7-16) | First | -- |
| Monday, September 14 |
| » Lost to White Sox (62-81), 8-2 | Comiskey Park I (3-2) | 77-68 | |
| » W: Dave LaPoint (5-4) L: Frank Viola (15-9) | First | -- |
| Tuesday, September 15 |
| » Lost to White Sox (63-81), 6-2 | Comiskey Park I (3-3) | 77-69 | Lost 2 |
| » W: Jack McDowell (1-0) L: Joe Niekro (6-12) | First | -- |
| » Major-league debuts: Jack McDowell (White Sox) |
| Wednesday, September 16 |
| » Lost to White Sox (64-81), 13-10 | Comiskey Park I (3-4) | 77-70 | Lost 3 |
| » W: Jose DeLeon (10-12) L: Mike Smithson (4-7) S: Bobby Thigpen (11) | First | -- |
| Friday, September 18 |
| » Defeated Indians (56-92), 9-4 | Hubert H. Humphrey Metrodome (50-23) | 78-70 | |
| » W: Bert Blyleven (14-11) L: Darrel Akerfelds (2-5) | First | -- |
| Saturday, September 19 |
| » Defeated Indians (56-93), 3-1 | Hubert H. Humphrey Metrodome (51-23) | 79-70 | Won 2 |
| » W: Frank Viola (16-9) L: Tom Candiotti (7-17) S: Jeff Reardon (27) | First | -- |
| Sunday, September 20 |
| » Defeated Indians (56-94), 3-2 | Hubert H. Humphrey Metrodome (52-23) | 80-70 | Won 3 |
| » W: Les Straker (8-9) L: Rich Yett (3-8) S: Jeff Reardon (28) | First | -- |
| Tuesday, September 22 |
| » Defeated Rangers (73-77), 6-4 | Hubert H. Humphrey Metrodome (53-23) | 81-70 | Won 4 |
| » W: Joe Niekro (7-12) L: Greg Harris (5-10) S: Jeff Reardon (29) | First | -- |
| Wednesday, September 23 |
| » Defeated Rangers |