| Monday, March 16 |
| Former Red Sox Bob Kline dies in Westerville, OH at the age of 78. |
| Monday, April 6 |
| » Lost to Brewers (1-0), 5-1 | County Stadium (0-1) | 0-1 | |
| » W: Teddy Higuera (1-0) L: Bob Stanley (0-1) | Second | 1 out |
| Wednesday, April 8 |
| » Lost to Brewers (2-0), 3-2 | County Stadium (0-2) | 0-2 | Lost 2 |
| » W: Chuck Crim (1-0) L: Wes Gardner (0-1) S: Dan Plesac (1) | Third | 2 out |
| » Major-league debuts: Chuck Crim and B.J. Surhoff (Brewers) |
| Thursday, April 9 |
| » Lost to Brewers (3-0), 12-11 | County Stadium (0-3) | 0-3 | Lost 3 |
| » W: Chris Bosio (1-0) L: Steve Crawford (0-1) S: Mark Clear (1) | Fourth | 3 out |
| » Major-league debuts: Mark Ciardi and Jim Paciorek (Brewers) Danny Sheaffer (Red Sox) |
| Friday, April 10 |
| » Defeated Blue Jays (2-2), 3-0 | Fenway Park (1-0) | 1-3 | |
| » W: Bruce Hurst (1-0) L: Dave Stieb (0-1) | Fourth | 3 out |
| Saturday, April 11 |
| » Lost to Blue Jays (3-2), 11-1 | Fenway Park (1-1) | 1-4 | |
| » W: Jimmy Key (2-0) L: Roger Clemens (0-1) | Fourth | 4 out |
| Sunday, April 12 |
| » Defeated Blue Jays (3-3), 8-3 | Fenway Park (2-1) | 2-4 | |
| » W: Bob Stanley (1-1) L: Jim Clancy (1-1) | Fifth | 4 out |
| Tuesday, April 14 |
| » Defeated Rangers (1-6), 4-1 | Fenway Park (3-1) | 3-4 | Won 2 |
| » W: Al Nipper (1-0) L: Ed Correa (0-1) S: Calvin Schiraldi (1) | Fourth | 4½ out |
| Wednesday, April 15 |
| » Defeated Rangers (1-7), 5-4 | Fenway Park (4-1) | 4-4 | Won 3 |
| » W: Bruce Hurst (2-0) L: Dale Mohorcic (1-1) S: Wes Gardner (1) | Fourth | 4½ out |
| Thursday, April 16 |
| » Lost to Blue Jays (5-4), 4-2 | Exhibition Stadium (0-1) | 4-5 | |
| » W: Jimmy Key (3-0) L: Roger Clemens (0-2) S: Tom Henke (1) | Fifth | 5 out |
| Friday, April 17 |
| » Lost to Blue Jays (6-4), 10-5 | Exhibition Stadium (0-2) | 4-6 | Lost 2 |
| » W: John Cerutti (1-0) L: Bob Stanley (1-2) S: Mark Eichhorn (1) | Fifth | 6 out |
| Saturday, April 18 |
| » Defeated Blue Jays (6-5), 6-4 | Exhibition Stadium (1-2) | 5-6 | |
| » W: Jeff Sellers (1-0) L: Jim Clancy (1-2) S: Calvin Schiraldi (2) | Sixth | 6 out |
| Sunday, April 19 |
| » Defeated Blue Jays (6-6), 4-1 | Exhibition Stadium (2-2) | 6-6 | Won 2 |
| » W: Al Nipper (2-0) L: Joe Johnson (0-2) S: Wes Gardner (2) | Fifth | 6 out |
| Monday, April 20 |
| » Lost to Royals (6-6), 10-2 | Fenway Park (4-2) | 6-7 | |
| » W: Bret Saberhagen (3-0) L: Bruce Hurst (2-1) | Fifth | 7 out |
| Tuesday, April 21 |
| » Defeated Royals (6-7), 8-0 | Fenway Park (5-2) | 7-7 | |
| » W: Roger Clemens (1-2) L: Rick Anderson (0-1) | Third | 6 out |
| Wednesday, April 22 |
| » Defeated Royals (6-8), 1-0 | Fenway Park (6-2) | 8-7 | Won 2 |
| » W: Bob Stanley (2-2) L: Danny Jackson (0-3) | Third | 5½ out |
| Friday, April 24 |
| » Lost to Rangers (4-11), 6-4 | Arlington Stadium (0-1) | 8-8 | |
| » W: Greg Harris (1-2) L: Calvin Schiraldi (0-1) | Fourth | 6½ out |
| Saturday, April 25 |
| » Lost to Rangers (5-11), 2-1 | Arlington Stadium (0-2) | 8-9 | Lost 2 |
| » W: Jose Guzman (1-1) L: Bruce Hurst (2-2) | Fourth | 7½ out |
| Sunday, April 26 |
| » Lost to Rangers (6-11), 5-3 | Arlington Stadium (0-3) | 8-10 | Lost 3 |
| » W: Mitch Williams (1-1) L: Calvin Schiraldi (0-2) | Fourth | 8½ out |
| Monday, April 27 |
| » Lost to Athletics (7-13), 5-2 | Oakland-Alameda County Stadium (0-1) | 8-11 | Lost 4 |
| » W: Curt Young (3-1) L: Bob Stanley (2-3) | Fourth | 9½ out |
| Tuesday, April 28 |
| » Lost to Athletics (8-13), 7-1 | Oakland-Alameda County Stadium (0-2) | 8-12 | Lost 5 |
| » W: Dennis Eckersley (1-1) L: Jeff Sellers (1-1) | Fifth | 9½ out |
| Wednesday, April 29 |
| » Defeated Mariners (11-11), 11-5 | Kingdome (1-0) | 9-12 | |
| » W: Al Nipper (3-0) L: Mike Moore (1-3) | Fourth | 9½ out |
| Thursday, April 30 |
| » Lost to Mariners (12-11), 11-2 | Kingdome (1-1) | 9-13 | |
| » W: Scott Bankhead (4-1) L: Bruce Hurst (2-3) | Fifth | 9½ out |
| » Major-league debuts: Ellis Burks (Red Sox) |
| Friday, May 1 |
| » Defeated Angels (12-12), 12-3 | Anaheim Stadium (1-0) | 10-13 | |
| » W: Roger Clemens (2-2) L: Urbano Lugo (0-1) | Fourth | 9½ out |
| Saturday, May 2 |
| » Lost to Angels (13-12), 4-2 | Anaheim Stadium (1-1) | 10-14 | |
| » W: Mike Witt (3-2) L: Bob Stanley (2-4) | Fourth | 10½ out |
| Sunday, May 3 |
| » Lost to Angels (14-12), 11-4 | Anaheim Stadium (1-2) | 10-15 | Lost 2 |
| » W: John Candelaria (4-0) L: Al Nipper (3-1) | Fourth | 10½ out |
| Tuesday, May 5 |
| » Defeated Athletics (12-15), 6-0 | Fenway Park (7-2) | 11-15 | |
| » W: Bruce Hurst (3-3) L: Dave Stewart (3-3) | Fourth | 9½ out |
| Wednesday, May 6 |
| » Defeated Athletics (12-16), 6-2 | Fenway Park (8-2) | 12-15 | Won 2 |
| » W: Calvin Schiraldi (1-2) L: Dennis Eckersley (2-2) | Fourth | 8½ out |
| Friday, May 8 |
| » Defeated Angels (16-13), 6-4 | Fenway Park (9-2) | 13-15 | Won 3 |
| » W: Joe Sambito (1-0) L: DeWayne Buice (1-1) | Fourth | 7½ out |
| Saturday, May 9 |
| » Lost to Angels (17-13), 8-1 | Fenway Park (9-3) | 13-16 | |
| » W: Willie Fraser (2-1) L: Al Nipper (3-2) | Fourth | 7½ out |
| Sunday, May 10 |
| » Defeated Angels (17-14), 7-0 | Fenway Park (10-3) | 14-16 | |
| » W: Bruce Hurst (4-3) L: Don Sutton (2-4) | Fourth | 6½ out |
| Monday, May 11 |
| » Lost to Mariners (18-14), 4-3 | Fenway Park (10-4) | 14-17 | |
| » W: Scott Bankhead (5-2) L: Roger Clemens (2-3) S: Ed Nunez (7) | Fourth | 7 out |
| Tuesday, May 12 |
| » Defeated Mariners (18-15), 3-2 | Fenway Park (11-4) | 15-17 | |
| » W: Jeff Sellers (2-1) L: Mike Trujillo (2-2) S: Wes Gardner (3) | Fourth | 6 out |
| Wednesday, May 13 |
| » Lost to Mariners (19-15), 5-4 | Fenway Park (11-5) | 15-18 | |
| » W: Mark Langston (4-3) L: Joe Sambito (1-1) S: Steve Shields (2) | Fourth | 6 out |
| Friday, May 15 |
| » Lost to Twins (18-17), 3-1 | Hubert H. Humphrey Metrodome (0-1) | 15-19 | Lost 2 |
| » W: George Frazier (4-2) L: Bruce Hurst (4-4) | Fifth | 7½ out |
| Saturday, May 16 |
| » Defeated Twins (18-18), 6-1 | Hubert H. Humphrey Metrodome (1-1) | 16-19 | |
| » W: Roger Clemens (3-3) L: Bert Blyleven (3-3) | Fifth | 6½ out |
| Sunday, May 17 |
| » Lost to Twins (19-18), 10-8 | Hubert H. Humphrey Metrodome (1-2) | 16-20 | |
| » W: Keith Atherton (2-0) L: Calvin Schiraldi (1-3) | Sixth | 7½ out |
| » Major-league debuts: Tom Bolton (Red Sox) |
| Monday, May 18 |
| » Lost to Royals (21-14), 4-2 | Royals Stadium (0-1) | 16-21 | Lost 2 |
| » W: Mark Gubicza (3-4) L: Al Nipper (3-3) S: Dan Quisenberry (4) | Sixth | 8½ out |
| Tuesday, May 19 |
| » Lost to Royals (22-14), 4-1 | Royals Stadium (0-2) | 16-22 | Lost 3 |
| » W: Bret Saberhagen (7-1) L: Bob Stanley (2-5) | Sixth | 8½ out |
| Wednesday, May 20 |
| » Defeated Royals (22-15), 7-1 | Royals Stadium (1-2) | 17-22 | |
| » W: Bruce Hurst (5-4) L: Danny Jackson (1-6) | Sixth | 7½ out |
| Friday, May 22 |
| » Lost to White Sox (15-22), 4-3 | Fenway Park (11-6) | 17-23 | |
| » W: Jim Winn (1-1) L: Roger Clemens (3-4) S: Bob James (4) | Sixth | 8½ out |
| Saturday, May 23 |
| » Lost to White Sox (16-22), 9-1 | Fenway Park (11-7) | 17-24 | Lost 2 |
| » W: Floyd Bannister (3-3) L: Al Nipper (3-4) | Sixth | 9½ out |
| Sunday, May 24 |
| » Lost to White Sox (17-22), 4-1 | Fenway Park (11-8) | 17-25 | Lost 3 |
| » W: Ray Searage (1-1) L: Bob Stanley (2-6) S: Bob James (5) | Sixth | 10½ out |
| Monday, May 25 |
| » Defeated Indians (15-29), 10-6 | Fenway Park (12-8) | 18-25 | |
| » W: Steve Crawford (1-1) L: Mark Huismann (0-2) | Sixth | 10½ out |
| Tuesday, May 26 |
| » Defeated Indians (15-30), 6-5 | Fenway Park (13-8) | 19-25 | Won 2 |
| » W: Al Nipper (4-4) L: Greg Swindell (3-4) | Sixth | 10 out |
| Wednesday, May 27 |
| » Defeated Indians (15-31), 1-0 | Fenway Park (14-8) | 20-25 | Won 3 |
| » W: Roger Clemens (4-4) L: Phil Niekro (2-5) | Sixth | 9 out |
| Thursday, May 28 |
| » Defeated Indians (15-32), 12-8 | Fenway Park (15-8) | 21-25 | Won 4 |
| » W: Steve Crawford (2-1) L: Rich Yett (1-3) S: Wes Gardner (4) | Sixth | 9 out |
| » Major-league debuts: John Leister (Red Sox) |
| Friday, May 29 |
| » Lost to White Sox (19-24), 8-6 | Comiskey Park I (0-1) | 21-26 | |
| » W: Jim Winn (2-1) L: Bob Stanley (2-7) S: Bob James (7) | Sixth | 9 out |
| Saturday, May 30 |
| » Lost to White Sox (20-24), 3-2 | Comiskey Park I (0-2) | 21-27 | Lost 2 |
| » W: Bob James (2-2) L: Wes Gardner (0-2) | Sixth | 9 out |
| Sunday, May 31 |
| » Defeated White Sox (20-25), 10-9 | Comiskey Park I (1-2) | 22-27 | |
| » W: Calvin Schiraldi (2-3) L: Ray Searage (1-2) | Sixth | 9 out |
| Former Red Sox Jerry Adair dies in Tulsa, OK at the age of 51. |
| Monday, June 1 |
| » Lost to Twins (27-23), 9-5 | Fenway Park (15-9) | 22-28 | |
| » W: Frank Viola (4-5) L: Roger Clemens (4-5) | Sixth | 9 out |
| Tuesday, June 2 |
| » Defeated Twins (27-24), 6-5 | Fenway Park (16-9) | 23-28 | |
| » W: Calvin Schiraldi (3-3) L: Jeff Reardon (2-4) | Sixth | 9 out |
| Wednesday, June 3 |
| » Defeated Twins (27-25), 7-6 | Fenway Park (17-9) | 24-28 | Won 2 |
| » W: Calvin Schiraldi (4-3) L: Joe Klink (0-1) | Sixth | 9 out |
| Thursday, June 4 |
| » Defeated Tigers (25-25), 8-5 | Fenway Park (18-9) | 25-28 | Won 3 |
| » W: Bruce Hurst (6-4) L: Walt Terrell (4-6) | Sixth | 8 out |
| Friday, June 5 |
| » Lost to Tigers (26-25), 4-2 | Fenway Park (18-10) | 25-29 | |
| » W: Jeff Robinson (4-2) L: Al Nipper (4-5) S: Eric King (3) | Sixth | 9 out |
| Saturday, June 6 |
| » Lost to Tigers (27-25), 5-3 | Fenway Park (18-11) | 25-30 | Lost 2 |
| » W: Eric King (3-4) L: Wes Gardner (0-3) | Sixth | 9 out |
| Sunday, June 7 |
| » Lost to Tigers (28-25), 18-8 | Fenway Park (18-12) | 25-31 | Lost 3 |
| » W: Mike Henneman (3-0) L: John Leister (0-1) | Sixth | 10 out |
| Monday, June 8 |
| » Defeated Orioles (27-29), 6-2 | Memorial Stadium (1-0) | 26-31 | |
| » W: Bob Stanley (3-7) L: Jeff Ballard (2-3) | Sixth | 9½ out |
| Tuesday, June 9 |
| » Defeated Orioles (27-30), 2-1 | Memorial Stadium (2-0) | 27-31 | Won 2 |
| » W: Bruce Hurst (7-4) L: Ken Dixon (3-6) | Sixth | 9½ out |
| Wednesday, June 10 |
| » Defeated Orioles (27-31), 15-4 | Memorial Stadium (3-0) | 28-31 | Won 3 |
| » W: Al Nipper (5-5) L: Eric Bell (5-4) | Fifth | 9½ out |
| Friday, June 12 |
| » Lost to Tigers (30-27), 11-4 | Tiger Stadium (0-1) | 28-32 | |
| » W: Frank Tanana (5-3) L: Roger Clemens (4-6) | Fifth | 11 out |
| Saturday, June 13 |
| » Lost to Tigers (31-27), 6-4 | Tiger Stadium (0-2) | 28-33 | Lost 2 |
| » W: Dan Petry (3-4) L: Steve Crawford (2-2) S: Guillermo Hernandez (1) | Fifth | 12 out |
| Sunday, June 14 |
| » Lost to Tigers (32-27), 2-1 | Tiger Stadium (0-3) | 28-34 | Lost 3 |
| » W: Jack Morris (9-2) L: Bruce Hurst (7-5) | Fifth | 12 out |
| Monday, June 15 |
| Former Red Sox George Smith dies in St.Petersburg, FL at the age of 50. |
| Tuesday, June 16 |
| » Lost to Indians (23-39), 8-7 | Cleveland Stadium (0-1) | 28-35 | Lost 4 |
| » W: Mark Huismann (2-3) L: Al Nipper (5-6) S: Mike Armstrong (1) | Fifth | 12½ out |
| Wednesday, June 17 |
| » Defeated Indians (23-40), 4-0 | Cleveland Stadium (1-1) | 29-35 | |
| » W: Roger Clemens (5-6) L: Tom Candiotti (2-7) | Fifth | 11½ out |
| Thursday, June 18 |
| » Lost to Indians (24-40), 7-5 | Cleveland Stadium (1-2) | 29-36 | |
| » W: Mike Armstrong (1-0) L: Bob Stanley (3-8) S: Mark Huismann (1) | Fourth | 11½ out |
| Friday, June 19 |
| » Lost to Yankees (42-25), 10-5 | Fenway Park (18-13) | 29-37 | Lost 2 |
| » W: Charles Hudson (7-2) L: Joe Sambito (1-2) | Fifth | 12½ out |
| Saturday, June 20 |
| » Defeated Yankees (42-26), 9-4 | Fenway Park (19-13) | 30-37 | |
| » W: Al Nipper (6-6) L: Tommy John (7-3) | Fifth | 11½ out |
| Sunday, June 21 |
| » Defeated Yankees (42-27), 4-2 | Fenway Park (20-13) | 31-37 | Won 2 |
| » W: Roger Clemens (6-6) L: Bob Tewksbury (0-2) | Fifth | 11½ out |
| » Major-league debuts: Todd Benzinger (Red Sox) |
| Monday, June 22 |
| » Defeated Brewers (35-31), 5-2 | Fenway Park (21-13) | 32-37 | Won 3 |
| » W: Oil Can Boyd (1-0) L: John Henry Johnson (0-1) | Fifth | 10½ out |
| Tuesday, June 23 |
| » Defeated Brewers (35-32), 9-5 | Fenway Park (22-13) | 33-37 | Won 4 |
| » W: Steve Crawford (3-2) L: Bill Wegman (6-7) S: Calvin Schiraldi (3) | Fifth | 10½ out |
| Wednesday, June 24 |
| » Defeated Brewers (35-33), 8-7 | Fenway Park (23-13) | 34-37 | Won 5 |
| » W: Bruce Hurst (8-5) L: Teddy Higuera (5-7) S: Calvin Schiraldi (4) | Fifth | 10½ out |
| Friday, June 26 |
| » Lost to Yankees (45-28), 12-11 | Yankee Stadium (0-1) | 34-38 | |
| » W: Tim Stoddard (1-1) L: Calvin Schiraldi (4-4) | Fifth | 10½ out |
| Saturday, June 27 |
| » Lost to Yankees (46-28), 9-1 | Yankee Stadium (0-2) | 34-39 | Lost 2 |
| » W: Bob Tewksbury (1-2) L: Oil Can Boyd (1-1) | Fifth | 11½ out |
| Sunday, June 28 |
| » Defeated Yankees (46-29), 6-2 | Yankee Stadium (1-2) | 35-39 | |
| » W: Al Nipper (7-6) L: Rick Rhoden (9-5) | Fifth | 10½ out |
| Monday, June 29 |
| » Defeated Orioles (31-45), 14-3 | Fenway Park (24-13) | 36-39 | Won 2 |
| » W: Bruce Hurst (9-5) L: Dave J. Schmidt (8-2) | Fifth | 10½ out |
| Tuesday, June 30 |
| » Defeated Orioles (31-46), 13-9 | Fenway Park (25-13) | 37-39 | Won 3 |
| » W: Steve Crawford (4-2) L: Mark Williamson (2-6) S: Calvin Schiraldi (5) | Fifth | 10½ out |
| Wednesday, July 1 |
| » Defeated Orioles (31-47), 6-2 | Fenway Park (26-13) | 38-39 | Won 4 |
| » W: Roger Clemens (7-6) L: Mike Griffin (0-2) | Fifth | 10½ out |
| Thursday, July 2 |
| » Lost to Athletics (41-36), 5-3 | Oakland-Alameda County Stadium (0-3) | 38-40 | |
| » W: Joaquin Andujar (3-1) L: Al Nipper (7-7) | Fifth | 11 out |
| Friday, July 3 |
| » Defeated Athletics (41-37), 2-0 | Oakland-Alameda County Stadium (1-3) | 39-40 | |
| » W: Jeff Sellers (3-1) L: Steve Ontiveros (5-2) | Fifth | 10½ out |
| Saturday, July 4 |
| » Lost to Athletics (42-37), 9-5 | Oakland-Alameda County Stadium (1-4) | 39-41 | |
| » W: Jose Rijo (1-4) L: Bruce Hurst (9-6) S: Dennis Eckersley (4) | Fifth | 11½ out |
| Sunday, July 5 |
| » Lost to Athletics (43-37), 6-3 | Oakland-Alameda County Stadium (1-5) | 39-42 | Lost 2 |
| » W: Dave Stewart (10-7) L: Oil Can Boyd (1-2) S: Dennis Eckersley (5) | Fifth | 11½ out |
| Monday, July 6 |
| » Lost to Angels (42-41), 10-7 | Anaheim Stadium (1-3) | 39-43 | Lost 3 |
| » W: Greg Minton (3-0) L: Wes Gardner (0-4) | Fifth | 11½ out |
| Tuesday, July 7 |
| » Lost to Angels (43-41), 9-4 | Anaheim Stadium (1-4) | 39-44 | Lost 4 |
| » W: Mike Witt (10-5) L: Al Nipper (7-8) S: DeWayne Buice (8) | Fifth | 12½ out |
| Wednesday, July 8 |
| » Lost to Angels (44-41), 5-3 | Anaheim Stadium (1-5) | 39-45 | Lost 5 |
| » W: Willie Fraser (6-6) L: Jeff Sellers (3-2) S: DeWayne Buice (9) | Fifth | 13½ out |
| Thursday, July 9 |
| » Lost to Mariners (44-41), 11-5 | Kingdome (1-2) | 39-46 | Lost 6 |
| » W: Roy Thomas (1-0) L: Wes Gardner (0-5) | Fifth | 13½ out |
| Friday, July 10 |
| » Defeated Mariners (44-42), 7-4 | Kingdome (2-2) | 40-46 | |
| » W: Calvin Schiraldi (5-4) L: Mark Langston (10-8) | Fifth | 13½ out |
| Saturday, July 11 |
| » Defeated Mariners (44-43), 10-4 | Kingdome (3-2) | 41-46 | Won 2 |
| » W: Roger Clemens (8-6) L: Mike Morgan (7-10) | Fifth | 12½ out |
| Sunday, July 12 |
| » Lost to Mariners (45-43), 6-1 | Kingdome (3-3) | 41-47 | |
| » W: Lee Guetterman (8-1) L: Al Nipper (7-9) S: Jerry Reed (3) | Fifth | 13½ out |
| Thursday, July 16 |
| » Lost to Athletics (47-41), 6-3 | Fenway Park (26-14) | 41-48 | Lost 2 |
| » W: Dave Stewart (12-7) L: Roger Clemens (8-7) S: Dennis Eckersley (7) | Fifth | 14½ out |
| Friday, July 17 |
| » Lost to Athletics (48-41), 11-6 | Fenway Park (26-15) | 41-49 | Lost 3 |
| » W: Greg Cadaret (1-0) L: Bob Stanley (3-9) | Fifth | 15½ out |
| Saturday, July 18 |
| » Defeated Athletics (48-42), 5-3 | Fenway Park (27-15) | 42-49 | |
| » W: Bruce Hurst (10-6) L: Dennis Eckersley (6-5) | Fifth | 14½ out |
| Sunday, July 19 |
| » Lost to Athletics (49-42), 5-3 | Fenway Park (27-16) | 42-50 | |
| » W: Jay Howell (3-3) L: Bob Stanley (3-10) S: Bill Caudill (1) | Fifth | 14½ out |
| Monday, July 20 |
| » Lost to Angels (49-45), 3-2 | Fenway Park (27-17) | 42-51 | Lost 2 |
| » W: Greg Minton (4-0) L: Jeff Sellers (3-3) S: DeWayne Buice (10) | Fifth | 15½ out |
| Former Red Sox Tom Winsett dies in Memphis, TN at the age of 78. |
| Tuesday, July 21 |
| » Defeated Angels (49-46), 3-0 | Fenway Park (28-17) | 43-51 | |
| » W: Roger Clemens (9-7) L: Kirk McCaskill (2-2) | Fifth | 14½ out |
| Wednesday, July 22 |
| » Lost to Angels (50-46), 6-5 | Fenway Park (28-18) | 43-52 | |
| » W: Mike Witt (12-6) L: Oil Can Boyd (1-3) S: Greg Minton (9) | Fifth | 14½ out |
| Former Red Sox Don McMahon dies in Los Angeles, CA at the age of 58. |
| Friday, July 24 |
| » Defeated Mariners (47-49), 5-4 | Fenway Park (29-18) | 44-52 | |
| » W: Bruce Hurst (11-6) L: Lee Guetterman (8-2) | Fifth | 13½ out |
| Saturday, July 25 |
| » Defeated Mariners (47-50), 11-5 | Fenway Park (30-18) | 45-52 | Won 2 |
| » W: Tom Bolton (1-0) L: Stan Clarke (2-2) | Fifth | 12½ out |
| » Major-league debuts: Sam Horn (Red Sox) |
| Sunday, July 26 |
| » Defeated Mariners (47-51), 11-1 | Fenway Park (31-18) | 46-52 | Won 3 |
| » W: Roger Clemens (10-7) L: Mike Moore (3-13) | Fifth | 12½ out |
| Monday, July 27 |
| » Lost to Blue Jays (58-41), 10-8 | Exhibition Stadium (2-3) | 46-53 | |
| » W: Jeff Musselman (8-4) L: Calvin Schiraldi (5-5) S: Tom Henke (22) | Fifth | 13 out |
| Tuesday, July 28 |
| » Lost to Blue Jays (59-41), 5-4 | Exhibition Stadium (2-4) | 46-54 | Lost 2 |
| » W: Jeff Musselman (9-4) L: Joe Sambito (1-3) S: Tom Henke (23) | Fifth | 14 out |
| Wednesday, July 29 |
| » Defeated Blue Jays (59-42), 6-5 | Exhibition Stadium (3-4) | 47-54 | |
| » W: Calvin Schiraldi (6-5) L: Gary Lavelle (1-3) | Fifth | 14 out |
| Friday, July 31 |
| » Defeated Royals (49-53), 4-0 | Royals Stadium (2-2) | 48-54 | Won 2 |
| » W: Roger Clemens (11-7) L: Bret Saberhagen (15-6) | Fifth | 14½ out |
| » Major-league debuts: John Marzano (Red Sox) |
| Saturday, August 1 |
| » Lost to Royals (50-53), 4-0 | Royals Stadium (2-3) | 48-55 | |
| » W: Charlie Leibrandt (11-8) L: Jeff Sellers (3-4) | Fifth | 14½ out |
| Sunday, August 2 |
| » Lost to Royals (51-53), 13-5 | Royals Stadium (2-4) | 48-56 | Lost 2 |
| » W: Mark Gubicza (9-10) L: Bob Stanley (3-11) | Fifth | 15½ out |
| Monday, August 3 |
| » Defeated Rangers (50-54), 11-2 | Arlington Stadium (1-3) | 49-56 | |
| » W: Bruce Hurst (12-6) L: Jose Guzman (8-11) | Fifth | 14½ out |
| Tuesday, August 4 |
| » Defeated Rangers (50-55), 8-6 | Arlington Stadium (2-3) | 50-56 | Won 2 |
| » W: Calvin Schiraldi (7-5) L: Dale Mohorcic (6-3) | Fifth | 13½ out |
| Wednesday, August 5 |
| » Lost to Rangers (51-55), 9-8 | Arlington Stadium (2-4) | 50-57 | |
| » W: Jose Guzman (9-11) L: Joe Sambito (1-4) | Fifth | 14½ out |
| Friday, August 7 |
| » Defeated Royals (53-55), 4-3 | Fenway Park (32-18) | 51-57 | |
| » W: Jeff Sellers (4-4) L: Charlie Leibrandt (11-9) | Fifth | 13½ out |
| Saturday, August 8 |
| » Defeated Royals (53-56), 8-3 | Fenway Park (33-18) | 52-57 | Won 2 |
| » W: Bruce Hurst (13-6) L: Mark Gubicza (9-11) | Fifth | 13 out |
| Sunday, August 9 |
| » Lost to Royals (54-56), 8-3 | Fenway Park (33-19) | 52-58 | |
| » W: John Davis (1-0) L: Steve Crawford (4-3) | Fifth | 13½ out |
| Monday, August 10 |
| » Defeated Blue Jays (66-46), 9-1 | Fenway Park (34-19) | 53-58 | |
| » W: Roger Clemens (12-7) L: Jim Clancy (10-9) | Fifth | 12½ out |
| Tuesday, August 11 |
| » Lost to Blue Jays (67-46), 8-3 | Fenway Park (34-20) | 53-59 | |
| » W: Jimmy Key (14-6) L: Bob Stanley (3-12) | Fifth | 13½ out |
| Wednesday, August 12 |
| » Lost to Blue Jays (68-46), 10-4 | Fenway Park (34-21) | 53-60 | Lost 2 |
| » W: Dave Stieb (12-5) L: Jeff Sellers (4-5) | Fifth | 14½ out |
| Friday, August 14 |
| » Defeated Rangers (54-59), 9-3 | Fenway Park (35-21) | 54-60 | |
| » W: Bruce Hurst (14-6) L: Steve Howe (0-1) | Fifth | 14½ out |
| » Lost to Rangers (55-59), 9-4 | Fenway Park (35-22) | 54-61 | |
| » W: Charlie Hough (12-8) L: Al Nipper (7-10) | Fifth | 14½ out |
| Saturday, August 15 |
| » Defeated Rangers (55-60), 7-6 | Fenway Park (36-22) | 55-61 | |
| » W: Wes Gardner (1-5) L: Steve Howe (0-2) | Fifth | 13½ out |
| Sunday, August 16 |
| » Defeated Rangers (55-61), 12-2 | Fenway Park (37-22) | 56-61 | Won 2 |
| » W: Bob Stanley (4-12) L: Greg Harris (5-9) | Fifth | 13½ out |
| Monday, August 17 |
| » Lost to White Sox (48-69), 2-1 | Comiskey Park I (1-3) | 56-62 | |
| » W: Dave LaPoint (3-1) L: Jeff Sellers (4-6) S: Bobby Thigpen (5) | Fifth | 14 out |
| Tuesday, August 18 |
| » Defeated White Sox (48-70), 14-8 | Comiskey Park I (2-3) | 57-62 | |
| » W: Al Nipper (8-10) L: Floyd Bannister (8-10) | Fifth | 14 out |
| Wednesday, August 19 |
| » Lost to White Sox (49-70), 8-3 | Comiskey Park I (2-4) | 57-63 | |
| » W: Jose DeLeon (6-11) L: Bruce Hurst (14-7) S: Bobby Thigpen (6) | Fifth | 14½ out |
| Friday, August 21 |
| » Defeated Twins (66-58), 11-3 | Fenway Park (38-22) | 58-63 | |
| » W: Roger Clemens (13-7) L: Frank Viola (14-8) S: Wes Gardner (5) | Fifth | 13½ out |
| Saturday, August 22 |
| » Defeated Twins (66-59), 6-5 | Fenway Park (39-22) | 59-63 | Won 2 |
| » W: Calvin Schiraldi (8-5) L: Les Straker (6-8) | Fifth | 13½ out |
| Sunday, August 23 |
| » Defeated Twins (66-60), 6-4 | Fenway Park (40-22) | 60-63 | Won 3 |
| » W: Jeff Sellers (5-6) L: Steve Carlton (6-13) S: Wes Gardner (6) | Fifth | 13½ out |
| Monday, August 24 |
| » Lost to White Sox (52-72), 6-3 | Fenway Park (40-23) | 60-64 | |
| » W: Jose DeLeon (7-11) L: Bruce Hurst (14-8) S: Scott Nielsen (1) | Fifth | 13½ out |
| Tuesday, August 25 |
| » Defeated White Sox (52-73), 7-3 | Fenway Park (41-23) | 61-64 | |
| » W: Steve Crawford (5-3) L: Richard Dotson (10-10) S: Wes Gardner (7) | Fifth | 13½ out |
| Wednesday, August 26 |
| » Lost to White Sox (53-73), 5-3 | Fenway Park (41-24) | 61-65 | |
| » W: Bill Long (8-6) L: Roger Clemens (13-8) S: Scott Nielsen (2) | Fifth | 14½ out |
| Saturday, August 29 |
| » Lost to Indians (49-80), 7-2 | Cleveland Stadium (1-3) | 61-66 | Lost 2 |
| » W: Tom Candiotti (7-13) L: Bob Stanley (4-13) | Fifth | 15½ out |
| » Lost to Indians (50-80), 2-1 | Cleveland Stadium (1-4) | 61-67 | Lost 3 |
| » W: Rich Yett (3-5) L: Bruce Hurst (14-9) | Fifth | 15½ out |
| Sunday, August 30 |
| » Defeated Indians (50-81), 7-3 | Cleveland Stadium (2-4) | 62-67 | |
| » W: Roger Clemens (14-8) L: Scott Bailes (6-7) S: Wes Gardner (8) | Fifth | 15½ out |
| Tuesday, September 1 |
| » Defeated Twins (69-64), 9-0 | Hubert H. Humphrey Metrodome (2-2) | 63-67 | Won 2 |
| » W: Jeff Sellers (6-6) L: Joe Niekro (6-11) | Fifth | 15 out |
| Wednesday, September 2 |
| » Lost to Twins (70-64), 5-4 | Hubert H. Humphrey Metrodome (2-3) | 63-68 | |
| » W: Les Straker (7-9) L: Al Nipper (8-11) S: Jeff Reardon (26) | Fifth | 16 out |
| Thursday, September 3 |
| » Lost to Twins (71-64), 2-1 | Hubert H. Humphrey Metrodome (2-4) | 63-69 | Lost 2 |
| » W: Keith Atherton (6-4) L: Wes Gardner (1-6) | Fifth | 17 out |
| Friday, September 4 |
| » Defeated Indians (51-85), 5-2 | Fenway Park (42-24) | 64-69 | |
| » W: Roger Clemens (15-8) L: Scott Bailes (6-8) S: Wes Gardner (9) | Fifth | 17 out |
| Saturday, September 5 |
| » Lost to Indians (52-85), 15-2 | Fenway Park (42-25) | 64-70 | |
| » W: John Farrell (4-0) L: Bob Stanley (4-14) | Fifth | 17 out |
| Sunday, September 6 |
| » Lost to Indians (53-85), 3-1 | Fenway Park (42-26) | 64-71 | Lost 2 |
| » W: Darrel Akerfelds (2-4) L: Jeff Sellers (6-7) S: Doug Jones (6) | Fifth | 17½ out |
| Monday, September 7 |
| » Lost to Yankees (78-59), 9-5 | Fenway Park (42-27) | 64-72 | Lost 3 |
| » W: Rick Rhoden (16-9) L: Bruce Hurst (14-10) S: Tim Stoddard (8) | Fifth | 18½ out |
| Tuesday, September 8 |
| » Defeated Yankees (78-60), 8-6 | Fenway Park (43-27) | 65-72 | |
| » W: Al Nipper (9-11) L: Bill Gullickson (12-12) S: Calvin Schiraldi (6) | Fifth | 17½ out |
| Wednesday, September 9 |
| » Defeated Yankees (78-61), 5-3 | Fenway Park (44-27) | 66-72 | Won 2 |
| » W: Roger Clemens (16-8) L: Charles Hudson (9-6) | Fifth | 18 out |
| Thursday, September 10 |
| » Defeated Orioles (62-78), 5-4 | Fenway Park (45-27) | 67-72 | Won 3 |
| » W: Joe Sambito (2-4) L: Tom Niedenfuer (4-4) S: Wes Gardner (10) | Fifth | 17 out |
| » Major-league debuts: Jose Mesa (Orioles) |
| Friday, September 11 |
| » Defeated Orioles (62-79), 9-3 | Fenway Park (46-27) | 68-72 | Won 4 |
| » W: Jeff Sellers (7-7) L: John Habyan (4-5) | Fourth | 16 out |
| Saturday, September 12 |
| » Defeated Orioles (62-80), 4-3 | Fenway Park (47-27) | 69-72 | Won 5 |
| » W: Bruce Hurst (15-10) L: Tom Niedenfuer (4-5) | Fifth | 16 out |
| » Major-league debuts: Jody Reed (Red Sox) |
| Monday, September 14 |
| » Lost to Tigers (86-57), 3-0 | Tiger Stadium (0-4) | 69-73 | |
| » W: Doyle Alexander (11-10) L: Roger Clemens (16-9) S: Mike Henneman (5) | Fourth | 16½ out |
| Tuesday, September 15 |
| » Lost to Tigers (87-57), 9-8 | Tiger Stadium (0-5) | 69-74 | Lost 2 |
| » W: Dan Petry (9-6) L: Steve Crawford (5-4) S: Mike Henneman (6) | Fourth | 17½ out |
| Wednesday, September 16 |
| » Lost to Tigers (88-57), 4-1 | Tiger Stadium (0-6) | 69-75 | Lost 3 |
| » W: Jack Morris (18-8) L: Jeff Sellers (7-8) | Fourth | 18½ out |
| Friday, September 18 |
| » Lost to Orioles (63-83), 9-4 | Memorial Stadium (3-1) | 69-76 | Lost 4 |
| » W: John Habyan (5-5) L: Bruce Hurst (15-11) S: Jack O'Connor (2) | Fourth | 19 out |
| » Defeated Orioles (63-84), 10-7 | Memorial Stadium (4-1) | 70-76 | |
| » W: Rob Woodward (1-0) L: Jeff Ballard (2-6) | Fourth | 19 out |
| Sunday, September 20 |
| » Defeated Orioles (63-85), 5-1 | Memorial Stadium (5-1) | 71-76 | Won 2 |
| » W: Roger Clemens (17-9) L: Jose Mesa (0-2) | Fourth | 18 out |
| » Defeated Orioles (63-86), 6-3 | Memorial Stadium (6-1) | 72-76 | Won 3 |
| » W: Wes Gardner (2-6) L: Luis DeLeon (0-2) < |