| Monday, April 6 |
| » Defeated Rangers (0-1), 2-1 | Memorial Stadium (1-0) | 1-0 | |
| » W: Don Aase (1-0) L: Greg Harris (0-1) | First | -- |
| Wednesday, April 8 |
| » Lost to Rangers (1-1), 6-4 | Memorial Stadium (1-1) | 1-1 | |
| » W: Dale Mohorcic (1-0) L: Mark Williamson (0-1) | Second | 1 out |
| » Major-league debuts: Mark Williamson (Orioles) |
| Thursday, April 9 |
| » Defeated Rangers (1-2), 8-6 | Memorial Stadium (2-1) | 2-1 | |
| » W: Ken Dixon (1-0) L: Mike Mason (0-1) | Second | 1 out |
| Friday, April 10 |
| » Defeated Indians (1-3), 12-11 | Cleveland Stadium (1-0) | 3-1 | Won 2 |
| » W: Mark Williamson (1-1) L: Ernie Camacho (0-1) | Second | 1 out |
| Saturday, April 11 |
| » Defeated Indians (1-4), 7-3 | Cleveland Stadium (2-0) | 4-1 | Won 3 |
| » W: Dave J. Schmidt (1-0) L: Tom Candiotti (0-2) | Second | 1 out |
| Sunday, April 12 |
| » Defeated Indians (1-5), 7-1 | Cleveland Stadium (3-0) | 5-1 | Won 4 |
| » W: Eric Bell (1-0) L: Ken Schrom (0-1) | Second | 1 out |
| » Major-league debuts: Dave Gallagher (Indians) |
| Monday, April 13 |
| » Lost to Brewers (7-0), 6-3 | Memorial Stadium (2-2) | 5-2 | |
| » W: Chris Bosio (2-0) L: Scott McGregor (0-1) | Second | 2 out |
| Tuesday, April 14 |
| » Lost to Brewers (8-0), 7-4 | Memorial Stadium (2-3) | 5-3 | Lost 2 |
| » W: Mark Ciardi (1-0) L: Ken Dixon (1-1) S: Dan Plesac (3) | Second | 3 out |
| Wednesday, April 15 |
| » Lost to Brewers (9-0), 7-0 | Memorial Stadium (2-4) | 5-4 | Lost 3 |
| » W: Juan Nieves (2-0) L: Mike Flanagan (0-1) | Third | 4 out |
| Friday, April 17 |
| » Defeated Indians (1-9), 4-1 | Memorial Stadium (3-4) | 6-4 | |
| » W: Mike Boddicker (1-0) L: Tom Candiotti (0-3) S: Mark Williamson (1) | Third | 4 out |
| Saturday, April 18 |
| » Defeated Indians (1-10), 16-3 | Memorial Stadium (4-4) | 7-4 | Won 2 |
| » W: Eric Bell (2-0) L: Ken Schrom (0-2) S: Dave J. Schmidt (1) | Third | 4 out |
| Sunday, April 19 |
| » Lost to Indians (2-10), 3-0 | Memorial Stadium (4-5) | 7-5 | |
| » W: Greg Swindell (1-2) L: Scott McGregor (0-2) | Fourth | 5½ out |
| » Lost to Indians (3-10), 8-7 | Memorial Stadium (4-6) | 7-6 | Lost 2 |
| » W: Steve Carlton (1-1) L: Mark Williamson (1-2) S: Ernie Camacho (1) | Fourth | 5½ out |
| Tuesday, April 21 |
| » Lost to Rangers (2-10), 6-4 | Arlington Stadium (0-1) | 7-7 | Lost 3 |
| » W: Charlie Hough (1-1) L: Mike Flanagan (0-2) | Third | 6 out |
| Wednesday, April 22 |
| » Defeated Rangers (2-11), 3-2 | Arlington Stadium (1-1) | 8-7 | |
| » W: Dave J. Schmidt (2-0) L: Mitch Williams (0-1) | Third | 5½ out |
| Thursday, April 23 |
| » Lost to Rangers (3-11), 9-4 | Arlington Stadium (1-2) | 8-8 | |
| » W: Mike Loynd (1-0) L: Eric Bell (2-1) S: Dale Mohorcic (1) | Fourth | 6 out |
| Friday, April 24 |
| » Lost to Brewers (14-1), 6-4 | County Stadium (0-1) | 8-9 | Lost 2 |
| » W: Teddy Higuera (4-0) L: Scott McGregor (0-3) | Fifth | 7 out |
| Saturday, April 25 |
| » Lost to Brewers (15-1), 8-2 | County Stadium (0-2) | 8-10 | Lost 3 |
| » W: Bill Wegman (2-0) L: Ken Dixon (1-2) | Fifth | 8 out |
| Sunday, April 26 |
| » Lost to Brewers (16-1), 5-3 | County Stadium (0-3) | 8-11 | Lost 4 |
| » W: Mike Birkbeck (1-0) L: Mike Flanagan (0-3) S: Dan Plesac (6) | Fifth | 9 out |
| Tuesday, April 28 |
| » Defeated Royals (8-10), 3-0 | Royals Stadium (1-0) | 9-11 | |
| » W: Mike Boddicker (2-0) L: Danny Jackson (0-4) | Fourth | 8½ out |
| Wednesday, April 29 |
| » Lost to Royals (9-10), 5-4 | Royals Stadium (1-1) | 9-12 | |
| » W: Dan Quisenberry (1-0) L: Dave J. Schmidt (2-1) | Fourth | 9½ out |
| Friday, May 1 |
| » Lost to White Sox (7-12), 5-1 | Memorial Stadium (4-7) | 9-13 | Lost 2 |
| » W: Floyd Bannister (2-1) L: Scott McGregor (0-4) | Fifth | 10 out |
| Saturday, May 2 |
| » Lost to White Sox (8-12), 7-3 | Memorial Stadium (4-8) | 9-14 | Lost 3 |
| » W: Jose DeLeon (3-2) L: Mike Flanagan (0-4) S: Jim Winn (2) | Fifth | 11 out |
| Sunday, May 3 |
| » Lost to White Sox (9-12), 4-3 | Memorial Stadium (4-9) | 9-15 | Lost 4 |
| » W: Bobby Thigpen (1-1) L: Mike Boddicker (2-1) S: Ray Searage (1) | Fifth | 11 out |
| Tuesday, May 5 |
| » Defeated Twins (14-11), 5-4 | Hubert H. Humphrey Metrodome (1-0) | 10-15 | |
| » W: Eric Bell (3-1) L: Mike Smithson (3-2) S: Ken Dixon (1) | Fifth | 10 out |
| Wednesday, May 6 |
| » Defeated Twins (14-12), 6-0 | Hubert H. Humphrey Metrodome (2-0) | 11-15 | Won 2 |
| » W: Scott McGregor (1-4) L: Bert Blyleven (2-2) | Fifth | 9 out |
| Thursday, May 7 |
| » Lost to Twins (15-12), 5-2 | Hubert H. Humphrey Metrodome (2-1) | 11-16 | |
| » W: Frank Viola (2-4) L: Mike Flanagan (0-5) S: Jeff Reardon (7) | Fifth | 9½ out |
| Friday, May 8 |
| » Defeated White Sox (10-15), 7-6 | Comiskey Park I (1-0) | 12-16 | |
| » W: Ken Dixon (2-2) L: Ray Searage (0-1) | Fifth | 8½ out |
| Saturday, May 9 |
| » Defeated White Sox (10-16), 15-6 | Comiskey Park I (2-0) | 13-16 | Won 2 |
| » W: Dave J. Schmidt (3-1) L: Joel McKeon (0-2) | Fourth | 7½ out |
| » Major-league debuts: Jeff Ballard (Orioles) |
| Sunday, May 10 |
| » Defeated White Sox (10-17), 6-4 | Comiskey Park I (3-0) | 14-16 | Won 3 |
| » W: Eric Bell (4-1) L: Richard Dotson (1-4) S: Mark Williamson (2) | Fourth | 6½ out |
| Monday, May 11 |
| » Lost to Twins (17-14), 10-4 | Memorial Stadium (4-10) | 14-17 | |
| » W: Bert Blyleven (3-2) L: Scott McGregor (1-5) | Fourth | 7 out |
| Tuesday, May 12 |
| » Defeated Twins (17-15), 10-7 | Memorial Stadium (5-10) | 15-17 | |
| » W: Ken Dixon (3-2) L: Jeff Reardon (1-3) | Fourth | 6 out |
| Wednesday, May 13 |
| » Lost to Royals (17-13), 8-7 | Memorial Stadium (5-11) | 15-18 | |
| » W: Steve Farr (1-1) L: Mark Williamson (1-3) | Fourth | 6 out |
| Thursday, May 14 |
| » Defeated Royals (17-14), 4-3 | Memorial Stadium (6-11) | 16-18 | |
| » W: Dave J. Schmidt (4-1) L: Bret Saberhagen (6-1) S: Ken Dixon (2) | Fourth | 6 out |
| Friday, May 15 |
| » Lost to Angels (19-16), 7-6 | Anaheim Stadium (0-1) | 16-19 | |
| » W: Donnie Moore (2-1) L: Jack O'Connor (0-1) | Fourth | 7 out |
| Saturday, May 16 |
| » Defeated Angels (19-17), 4-2 | Anaheim Stadium (1-1) | 17-19 | |
| » W: Scott McGregor (2-5) L: Mike Witt (5-3) S: Jack O'Connor (1) | Fourth | 6 out |
| » Major-league debuts: Bryan Harvey (Angels) |
| Sunday, May 17 |
| » Defeated Angels (19-18), 3-2 | Anaheim Stadium (2-1) | 18-19 | Won 2 |
| » W: Dave J. Schmidt (5-1) L: DeWayne Buice (1-2) S: Don Aase (1) | Fourth | 6 out |
| Monday, May 18 |
| » Defeated Mariners (20-18), 6-0 | Kingdome (1-0) | 19-19 | Won 3 |
| » W: Mike Boddicker (3-1) L: Mark Langston (4-4) | Fourth | 6 out |
| Tuesday, May 19 |
| » Defeated Mariners (20-19), 15-4 | Kingdome (2-0) | 20-19 | Won 4 |
| » W: Jeff Ballard (1-0) L: Mike Trujillo (2-3) | Fourth | 5 out |
| Wednesday, May 20 |
| » Lost to Mariners (21-19), 6-2 | Kingdome (2-1) | 20-20 | |
| » W: Mike Morgan (4-4) L: Ken Dixon (3-3) | Fourth | 5 out |
| Friday, May 22 |
| » Defeated Athletics (20-20), 10-6 | Oakland-Alameda County Stadium (1-0) | 21-20 | |
| » W: Dave J. Schmidt (6-1) L: Moose Haas (1-1) S: Ken Dixon (3) | Fourth | 5 out |
| Saturday, May 23 |
| » Defeated Athletics (20-21), 5-4 | Oakland-Alameda County Stadium (2-0) | 22-20 | Won 2 |
| » W: Mike Boddicker (4-1) L: Dave Stewart (5-4) S: Don Aase (2) | Fourth | 5 out |
| Sunday, May 24 |
| » Defeated Athletics (20-22), 4-3 | Oakland-Alameda County Stadium (3-0) | 23-20 | Won 3 |
| » W: Jeff Ballard (2-0) L: Curt Young (5-3) S: Ken Dixon (4) | Fourth | 5 out |
| Monday, May 25 |
| » Defeated Athletics (20-23), 4-3 | Oakland-Alameda County Stadium (4-0) | 24-20 | Won 4 |
| » W: Eric Bell (5-1) L: Dennis Eckersley (3-3) S: Ken Dixon (5) | Fourth | 5 out |
| Wednesday, May 27 |
| » Defeated Angels (21-24), 8-6 | Memorial Stadium (7-11) | 25-20 | Won 5 |
| » W: John Habyan (1-0) L: Gary Lucas (1-2) S: Tom Niedenfuer (2) | Third | 4 out |
| Thursday, May 28 |
| » Defeated Angels (21-25), 8-7 | Memorial Stadium (8-11) | 26-20 | Won 6 |
| » W: Mark Williamson (2-3) L: DeWayne Buice (2-3) | Third | 4 out |
| Friday, May 29 |
| » Lost to Mariners (24-23), 7-3 | Memorial Stadium (8-12) | 26-21 | |
| » W: Mark Langston (6-4) L: Jeff Ballard (2-1) | Third | 4 out |
| Saturday, May 30 |
| » Lost to Mariners (25-23), 12-0 | Memorial Stadium (8-13) | 26-22 | Lost 2 |
| » W: Mike Morgan (5-5) L: Eric Bell (5-2) | Third | 4 out |
| Sunday, May 31 |
| » Lost to Mariners (26-23), 8-5 | Memorial Stadium (8-14) | 26-23 | Lost 3 |
| » W: Lee Guetterman (2-0) L: John Habyan (1-1) | Fourth | 5 out |
| Former Oriole Jerry Adair dies in Tulsa, OK at the age of 51. |
| Monday, June 1 |
| » Lost to Athletics (25-24), 9-6 | Memorial Stadium (8-15) | 26-24 | Lost 4 |
| » W: Gene Nelson (3-1) L: Ken Dixon (3-4) S: Jay Howell (9) | Fourth | 5 out |
| Tuesday, June 2 |
| » Defeated Athletics (25-25), 9-2 | Memorial Stadium (9-15) | 27-24 | |
| » W: Mike Boddicker (5-1) L: Dave Stewart (6-5) | Fourth | 5 out |
| Wednesday, June 3 |
| » Lost to Athletics (26-25), 7-3 | Memorial Stadium (9-16) | 27-25 | |
| » W: Curt Young (7-3) L: Jeff Ballard (2-2) | Fourth | 6 out |
| Friday, June 5 |
| » Lost to Blue Jays (31-20), 6-2 | Exhibition Stadium (0-1) | 27-26 | Lost 2 |
| » W: Jimmy Key (7-3) L: Eric Bell (5-3) | Fifth | 6½ out |
| Saturday, June 6 |
| » Lost to Blue Jays (32-20), 8-5 | Exhibition Stadium (0-2) | 27-27 | Lost 3 |
| » W: Jeff Musselman (4-1) L: Ken Dixon (3-5) | Fifth | 6½ out |
| Sunday, June 7 |
| » Lost to Blue Jays (33-20), 3-2 | Exhibition Stadium (0-3) | 27-28 | Lost 4 |
| » W: Mark Eichhorn (7-2) L: Mike Boddicker (5-2) | Fifth | 7½ out |
| Monday, June 8 |
| » Lost to Red Sox (26-31), 6-2 | Memorial Stadium (9-17) | 27-29 | Lost 5 |
| » W: Bob Stanley (3-7) L: Jeff Ballard (2-3) | Fifth | 8 out |
| Tuesday, June 9 |
| » Lost to Red Sox (27-31), 2-1 | Memorial Stadium (9-18) | 27-30 | Lost 6 |
| » W: Bruce Hurst (7-4) L: Ken Dixon (3-6) | Fifth | 9 out |
| Wednesday, June 10 |
| » Lost to Red Sox (28-31), 15-4 | Memorial Stadium (9-19) | 27-31 | Lost 7 |
| » W: Al Nipper (5-5) L: Eric Bell (5-4) | Sixth | 10 out |
| Thursday, June 11 |
| » Lost to Blue Jays (37-20), 8-6 | Memorial Stadium (9-20) | 27-32 | Lost 8 |
| » W: Joe Johnson (3-5) L: John Habyan (1-2) S: Tom Henke (11) | Sixth | 11 out |
| Friday, June 12 |
| » Lost to Blue Jays (38-20), 8-5 | Memorial Stadium (9-21) | 27-33 | Lost 9 |
| » W: Mark Eichhorn (8-2) L: Mike Boddicker (5-3) S: Jeff Musselman (2) | Sixth | 12 out |
| Saturday, June 13 |
| » Lost to Blue Jays (39-20), 8-2 | Memorial Stadium (9-22) | 27-34 | Lost 10 |
| » W: John Cerutti (4-2) L: Scott McGregor (2-6) | Sixth | 13 out |
| Sunday, June 14 |
| » Defeated Blue Jays (39-21), 8-5 | Memorial Stadium (10-22) | 28-34 | |
| » W: Dave J. Schmidt (7-1) L: Mark Eichhorn (8-3) S: Luis DeLeon (1) | Fifth | 12 out |
| Monday, June 15 |
| » Lost to Yankees (38-25), 9-2 | Yankee Stadium (0-1) | 28-35 | |
| » W: Tommy John (7-2) L: Eric Bell (5-5) S: Pat Clements (2) | Sixth | 12 out |
| Tuesday, June 16 |
| » Lost to Yankees (39-25), 6-5 | Yankee Stadium (0-2) | 28-36 | Lost 2 |
| » W: Rich Bordi (3-0) L: Mark Williamson (2-4) S: Dave Righetti (14) | Sixth | 13 out |
| Wednesday, June 17 |
| » Lost to Yankees (40-25), 4-3 | Yankee Stadium (0-3) | 28-37 | Lost 3 |
| » W: Dennis Rasmussen (5-4) L: Mike Boddicker (5-4) S: Pat Clements (3) | Sixth | 13 out |
| Thursday, June 18 |
| » Lost to Yankees (41-25), 6-3 | Yankee Stadium (0-4) | 28-38 | Lost 4 |
| » W: Rick Rhoden (8-4) L: Scott McGregor (2-7) S: Tim Stoddard (3) | Fifth | 13 out |
| Friday, June 19 |
| » Lost to Tigers (35-28), 5-3 | Memorial Stadium (10-23) | 28-39 | Lost 5 |
| » W: Jack Morris (10-2) L: Mark Williamson (2-5) S: Guillermo Hernandez (3) | Sixth | 14 out |
| Saturday, June 20 |
| » Game at Memorial Stadium interrupted in the 9th inning with the score of Orioles 9, Tigers 4. Completed on June 21. |
| Sunday, June 21 |
| » Defeated Tigers (35-29), 9-5 | Memorial Stadium (11-23) | 29-39 | |
| » W: Eric Bell (6-5) L: Walt Terrell (5-7) S: Tom Niedenfuer (3) | Sixth | 14 out |
| » Lost to Tigers (36-29), 9-3 | Memorial Stadium (11-24) | 29-40 | |
| » W: Dan Petry (4-4) L: Ken Dixon (3-7) S: Eric King (5) | Sixth | 14 out |
| Monday, June 22 |
| » Lost to Yankees (43-27), 7-3 | Memorial Stadium (11-25) | 29-41 | Lost 2 |
| » W: Dennis Rasmussen (6-4) L: Luis DeLeon (0-1) | Sixth | 14 out |
| Tuesday, June 23 |
| » Lost to Yankees (44-27), 2-1 | Memorial Stadium (11-26) | 29-42 | Lost 3 |
| » W: Rick Rhoden (9-4) L: Doug Corbett (0-1) S: Dave Righetti (15) | Sixth | 15 out |
| Wednesday, June 24 |
| » Defeated Yankees (44-28), 4-0 | Memorial Stadium (12-26) | 30-42 | |
| » W: Dave J. Schmidt (8-1) L: Ron Guidry (0-3) | Sixth | 15 out |
| Friday, June 26 |
| » Lost to Tigers (38-31), 9-0 | Tiger Stadium (0-1) | 30-43 | |
| » W: Walt Terrell (6-7) L: Mike Griffin (0-1) | Sixth | 15 out |
| Saturday, June 27 |
| » Defeated Tigers (38-32), 4-2 | Tiger Stadium (1-1) | 31-43 | |
| » W: Tom Niedenfuer (2-0) L: Frank Tanana (7-4) | Sixth | 15 out |
| Sunday, June 28 |
| » Lost to Tigers (39-32), 8-7 | Tiger Stadium (1-2) | 31-44 | |
| » W: Guillermo Hernandez (1-1) L: Doug Corbett (0-2) | Sixth | 15 out |
| Monday, June 29 |
| » Lost to Red Sox (36-39), 14-3 | Fenway Park (0-1) | 31-45 | Lost 2 |
| » W: Bruce Hurst (9-5) L: Dave J. Schmidt (8-2) | Sixth | 16 out |
| Tuesday, June 30 |
| » Lost to Red Sox (37-39), 13-9 | Fenway Park (0-2) | 31-46 | Lost 3 |
| » W: Steve Crawford (4-2) L: Mark Williamson (2-6) S: Calvin Schiraldi (5) | Sixth | 17 out |
| Wednesday, July 1 |
| » Lost to Red Sox (38-39), 6-2 | Fenway Park (0-3) | 31-47 | Lost 4 |
| » W: Roger Clemens (7-6) L: Mike Griffin (0-2) | Sixth | 18 out |
| Friday, July 3 |
| » Lost to Twins (44-36), 6-5 | Hubert H. Humphrey Metrodome (2-2) | 31-48 | Lost 5 |
| » W: Jeff Reardon (5-4) L: Tom Niedenfuer (2-1) | Sixth | 18½ out |
| Saturday, July 4 |
| » Lost to Twins (45-36), 4-1 | Hubert H. Humphrey Metrodome (2-3) | 31-49 | Lost 6 |
| » W: Les Straker (4-5) L: Eric Bell (6-6) S: Juan Berenguer (3) | Sixth | 19½ out |
| Sunday, July 5 |
| » Lost to Twins (46-36), 4-3 | Hubert H. Humphrey Metrodome (2-4) | 31-50 | Lost 7 |
| » W: Bert Blyleven (8-6) L: Tom Niedenfuer (2-2) | Sixth | 19½ out |
| Monday, July 6 |
| » Defeated White Sox (31-48), 4-1 | Memorial Stadium (13-26) | 32-50 | |
| » W: Mike Griffin (1-2) L: Jose DeLeon (5-8) S: Mark Williamson (3) | Sixth | 18½ out |
| Tuesday, July 7 |
| » Lost to White Sox (32-48), 9-3 | Memorial Stadium (13-27) | 32-51 | |
| » W: Floyd Bannister (4-7) L: John Habyan (1-3) | Sixth | 19½ out |
| Wednesday, July 8 |
| » Defeated White Sox (32-49), 6-5 | Memorial Stadium (14-27) | 33-51 | |
| » W: Mike Boddicker (6-4) L: Jim Winn (4-5) | Sixth | 19½ out |
| Thursday, July 9 |
| » Lost to Twins (48-38), 3-1 | Memorial Stadium (14-28) | 33-52 | |
| » W: Les Straker (5-5) L: Eric Bell (6-7) S: Jeff Reardon (17) | Sixth | 19½ out |
| Friday, July 10 |
| » Defeated Twins (48-39), 13-12 | Memorial Stadium (15-28) | 34-52 | |
| » W: Mark Williamson (3-6) L: George Frazier (5-4) | Sixth | 19½ out |
| Saturday, July 11 |
| » Lost to Twins (49-39), 2-1 | Memorial Stadium (15-29) | 34-53 | |
| » W: Frank Viola (8-6) L: Mike Griffin (1-3) | Sixth | 19½ out |
| » Major-league debuts: Billy Ripken (Orioles) |
| Sunday, July 12 |
| » Defeated Twins (49-40), 5-0 | Memorial Stadium (16-29) | 35-53 | |
| » W: Dave J. Schmidt (9-2) L: Joe Niekro (5-6) | Sixth | 19½ out |
| Thursday, July 16 |
| » Defeated Royals (46-42), 5-4 | Royals Stadium (2-1) | 36-53 | Won 2 |
| » W: Mike Boddicker (7-4) L: Charlie Leibrandt (8-8) S: Tom Niedenfuer (4) | Sixth | 19½ out |
| Friday, July 17 |
| » Defeated Royals (46-43), 3-1 | Royals Stadium (3-1) | 37-53 | Won 3 |
| » W: Eric Bell (7-7) L: Mark Gubicza (7-9) S: Tom Niedenfuer (5) | Sixth | 19½ out |
| Saturday, July 18 |
| » Defeated Royals (46-44), 11-7 | Royals Stadium (4-1) | 38-53 | Won 4 |
| » W: Mike Flanagan (1-5) L: Danny Jackson (4-11) | Sixth | 18½ out |
| Sunday, July 19 |
| » Defeated Royals (46-45), 5-1 | Royals Stadium (5-1) | 39-53 | Won 5 |
| » W: Dave J. Schmidt (10-2) L: Buddy Black (4-5) | Sixth | 17½ out |
| Monday, July 20 |
| » Defeated White Sox (37-53), 4-1 | Comiskey Park I (4-0) | 40-53 | Won 6 |
| » W: Mike Griffin (2-3) L: Neil Allen (0-4) S: Doug Corbett (1) | Sixth | 17½ out |
| Tuesday, July 21 |
| » Defeated White Sox (37-54), 11-6 | Comiskey Park I (5-0) | 41-53 | Won 7 |
| » W: Mark Williamson (4-6) L: Bill Long (5-5) | Sixth | 16½ out |
| Wednesday, July 22 |
| » Defeated White Sox (37-55), 10-5 | Comiskey Park I (6-0) | 42-53 | Won 8 |
| » W: John Habyan (2-3) L: Jose DeLeon (5-9) | Sixth | 15½ out |
| Thursday, July 23 |
| » Defeated Royals (48-47), 2-1 | Memorial Stadium (17-29) | 43-53 | Won 9 |
| » W: Eric Bell (8-7) L: Danny Jackson (4-12) | Sixth | 15 out |
| » Major-league debuts: Mike Macfarlane (Royals) |
| Friday, July 24 |
| » Defeated Royals (48-48), 3-1 | Memorial Stadium (18-29) | 44-53 | Won 10 |
| » W: Tom Niedenfuer (3-2) L: Steve Farr (3-3) | Sixth | 14 out |
| » Major-league debuts: John Davis (Royals) |
| Saturday, July 25 |
| » Defeated Royals (48-49), 4-3 | Memorial Stadium (19-29) | 45-53 | Won 11 |
| » W: Mark Williamson (5-6) L: Bret Saberhagen (15-5) S: Tom Niedenfuer (6) | Sixth | 13 out |
| Sunday, July 26 |
| » Lost to Royals (49-49), 4-0 | Memorial Stadium (19-30) | 45-54 | |
| » W: Charlie Leibrandt (10-8) L: Ken Dixon (3-8) | Sixth | 14 out |
| Monday, July 27 |
| » Major-league debuts: Tim Crews (Dodgers) |
| Tuesday, July 28 |
| » Lost to Indians (35-64), 4-3 | Cleveland Stadium (3-1) | 45-55 | Lost 2 |
| » W: Sammy Stewart (3-1) L: Tom Niedenfuer (3-3) | Sixth | 15 out |
| Wednesday, July 29 |
| » Defeated Indians (35-65), 7-4 | Cleveland Stadium (4-1) | 46-55 | |
| » W: Eric Bell (9-7) L: Tom Candiotti (3-11) | Sixth | 15 out |
| Thursday, July 30 |
| » Lost to Indians (36-65), 6-4 | Cleveland Stadium (4-2) | 46-56 | |
| » W: Sammy Stewart (4-1) L: Mark Williamson (5-7) | Sixth | 16 out |
| Friday, July 31 |
| » Defeated Rangers (49-52), 8-4 | Arlington Stadium (2-2) | 47-56 | |
| » W: John Habyan (3-3) L: Charlie Hough (11-7) S: Tom Niedenfuer (7) | Sixth | 16 out |
| Saturday, August 1 |
| » Defeated Rangers (49-53), 7-1 | Arlington Stadium (3-2) | 48-56 | Won 2 |
| » W: Ken Dixon (4-8) L: Paul Kilgus (1-3) S: Mike Griffin (1) | Sixth | 15 out |
| Sunday, August 2 |
| » Lost to Rangers (50-53), 5-2 | Arlington Stadium (3-3) | 48-57 | |
| » W: Bobby Witt (5-5) L: Mike Boddicker (7-5) | Sixth | 16 out |
| Tuesday, August 4 |
| » Lost to Brewers (53-51), 9-8 | County Stadium (0-4) | 48-58 | Lost 2 |
| » W: Mark Knudson (2-2) L: Mark Williamson (5-8) | Sixth | 15½ out |
| Wednesday, August 5 |
| » Lost to Brewers (54-51), 5-1 | County Stadium (0-5) | 48-59 | Lost 3 |
| » W: Teddy Higuera (11-8) L: Eric Bell (9-8) | Sixth | 16½ out |
| Thursday, August 6 |
| » Lost to Brewers (55-51), 11-8 | County Stadium (0-6) | 48-60 | Lost 4 |
| » W: Jay Aldrich (1-1) L: Mike Griffin (2-4) S: Chuck Crim (2) | Sixth | 16½ out |
| Friday, August 7 |
| » Defeated Rangers (51-56), 9-2 | Memorial Stadium (20-30) | 49-60 | |
| » W: Ken Dixon (5-8) L: Paul Kilgus (1-4) | Sixth | 16 out |
| Saturday, August 8 |
| » Lost to Rangers (52-56), 11-5 | Memorial Stadium (20-31) | 49-61 | |
| » W: Bobby Witt (6-5) L: Mike Boddicker (7-6) S: Mitch Williams (2) | Sixth | 16½ out |
| Sunday, August 9 |
| » Defeated Rangers (52-57), 5-4 | Memorial Stadium (21-31) | 50-61 | |
| » W: John Habyan (4-3) L: Charlie Hough (11-8) | Sixth | 16 out |
| Monday, August 10 |
| » Defeated Indians (41-71), 4-3 | Memorial Stadium (22-31) | 51-61 | Won 2 |
| » W: Mark Williamson (6-8) L: Don Gordon (0-1) S: Tom Niedenfuer (8) | Sixth | 15 out |
| Tuesday, August 11 |
| » Lost to Indians (42-71), 6-3 | Memorial Stadium (22-32) | 51-62 | |
| » W: Scott Bailes (6-4) L: Dave J. Schmidt (10-3) S: Doug Jones (2) | Sixth | 16 out |
| Wednesday, August 12 |
| » Lost to Indians (43-71), 8-6 | Memorial Stadium (22-33) | 51-63 | Lost 2 |
| » W: Darrel Akerfelds (1-3) L: Mike Griffin (2-5) S: Doug Jones (3) | Sixth | 17 out |
| Thursday, August 13 |
| » Defeated Brewers (59-55), 5-4 | Memorial Stadium (23-33) | 52-63 | |
| » W: Mike Boddicker (8-6) L: Chris Bosio (7-5) S: Tom Niedenfuer (9) | Sixth | 16 out |
| Friday, August 14 |
| » Lost to Brewers (60-55), 6-2 | Memorial Stadium (23-34) | 52-64 | |
| » W: Juan Nieves (9-6) L: Eric Bell (9-9) S: Chuck Crim (4) | Sixth | 17 out |
| Saturday, August 15 |
| » Defeated Brewers (60-56), 2-1 | Memorial Stadium (24-34) | 53-64 | |
| » W: Mike Flanagan (2-5) L: Teddy Higuera (11-9) | Sixth | 16 out |
| Sunday, August 16 |
| » Lost to Brewers (61-56), 6-2 | Memorial Stadium (24-35) | 53-65 | |
| » W: Chuck Crim (5-5) L: Dave J. Schmidt (10-4) S: Dan Plesac (22) | Sixth | 17 out |
| Monday, August 17 |
| » Major-league debuts: Tom Glavine (Braves) |
| Tuesday, August 18 |
| » Defeated Angels (60-60), 4-1 | Anaheim Stadium (3-1) | 54-65 | |
| » W: Ken Dixon (6-8) L: Kirk McCaskill (3-5) S: John Habyan (1) | Sixth | 17 out |
| Wednesday, August 19 |
| » Defeated Angels (60-61), 2-1 | Anaheim Stadium (4-1) | 55-65 | Won 2 |
| » W: Mike Boddicker (9-6) L: Don Sutton (8-10) S: Tom Niedenfuer (10) | Sixth | 16½ out |
| Thursday, August 20 |
| » Defeated Angels (60-62), 4-2 | Anaheim Stadium (5-1) | 56-65 | Won 3 |
| » W: Mark Williamson (7-8) L: DeWayne Buice (5-5) | Sixth | 16½ out |
| Friday, August 21 |
| » Lost to Mariners (58-64), 3-2 | Kingdome (2-2) | 56-66 | |
| » W: Mike Moore (6-15) L: Mike Flanagan (2-6) | Sixth | 16 out |
| Saturday, August 22 |
| » Lost to Mariners (59-64), 14-6 | Kingdome (2-3) | 56-67 | Lost 2 |
| » W: Mark Langston (14-10) L: Dave J. Schmidt (10-5) | Sixth | 17 out |
| Sunday, August 23 |
| » Defeated Mariners (59-65), 6-5 | Kingdome (3-3) | 57-67 | |
| » W: Ken Dixon (7-8) L: Dennis Powell (0-2) | Sixth | 17 out |
| Monday, August 24 |
| » Lost to Athletics (64-61), 7-3 | Oakland-Alameda County Stadium (4-1) | 57-68 | |
| » W: Greg Cadaret (3-1) L: Mike Boddicker (9-7) | Sixth | 17 out |
| Tuesday, August 25 |
| » Lost to Athletics (65-61), 9-7 | Oakland-Alameda County Stadium (4-2) | 57-69 | Lost 2 |
| » W: Curt Young (11-6) L: Eric Bell (9-10) S: Eric Plunk (1) | Sixth | 18 out |
| Thursday, August 27 |
| » Defeated Angels (63-65), 9-5 | Memorial Stadium (25-35) | 58-69 | |
| » W: Mike Flanagan (3-6) L: Jerry Reuss (4-7) | Sixth | 18 out |
| Friday, August 28 |
| » Defeated Angels (63-66), 6-5 | Memorial Stadium (26-35) | 59-69 | Won 2 |
| » W: Mark Williamson (8-8) L: Chuck Finley (2-6) | Sixth | 17 out |
| Saturday, August 29 |
| » Lost to Angels (64-66), 6-5 | Memorial Stadium (26-36) | 59-70 | |
| » W: Willie Fraser (8-8) L: Mark Williamson (8-9) | Sixth | 18 out |
| Sunday, August 30 |
| » Lost to Angels (65-66), 6-2 | Memorial Stadium (26-37) | 59-71 | Lost 2 |
| » W: Don Sutton (9-10) L: Eric Bell (9-11) | Sixth | 19 out |
| Monday, August 31 |
| » Defeated Mariners (61-70), 4-3 | Memorial Stadium (27-37) | 60-71 | |
| » W: Mike Griffin (3-5) L: Mike Morgan (10-15) S: Tom Niedenfuer (11) | Sixth | 18 out |
| Tuesday, September 1 |
| » Lost to Mariners (62-70), 5-0 | Memorial Stadium (27-38) | 60-72 | |
| » W: Scott Bankhead (8-8) L: John Habyan (4-4) | Sixth | 19 out |
| Wednesday, September 2 |
| » Lost to Mariners (63-70), 8-6 | Memorial Stadium (27-39) | 60-73 | Lost 2 |
| » W: Mark Langston (16-10) L: Jeff Ballard (2-4) S: Jerry Reed (4) | Sixth | 20 out |
| Former Oriole Cam Carreon dies in Tucson, AZ at the age of 51. |
| Friday, September 4 |
| » Defeated Athletics (68-66), 5-2 | Memorial Stadium (28-39) | 61-73 | |
| » W: Mike Boddicker (10-7) L: Gene Nelson (6-4) | Sixth | 20½ out |
| Saturday, September 5 |
| » Lost to Athletics (69-66), 7-2 | Memorial Stadium (28-40) | 61-74 | |
| » W: Curt Young (12-7) L: Eric Bell (9-12) | Sixth | 20½ out |
| Sunday, September 6 |
| » Defeated Athletics (69-67), 7-6 | Memorial Stadium (29-40) | 62-74 | |
| » W: Tom Niedenfuer (4-3) L: Dennis Eckersley (6-7) | Sixth | 20 out |
| Monday, September 7 |
| » Lost to Tigers (82-54), 12-4 | Memorial Stadium (29-41) | 62-75 | |
| » W: Jack Morris (17-7) L: Jeff Ballard (2-5) | Sixth | 21 out |
| Tuesday, September 8 |
| » Major-league debuts: Pete Smith (Braves) Shawn Abner (Padres) |
| Wednesday, September 9 |
| » Lost to Tigers (83-54), 7-4 | Memorial Stadium (29-42) | 62-76 | Lost 2 |
| » W: Walt Terrell (13-10) L: Ken Dixon (7-9) S: Guillermo Hernandez (8) | Sixth | 22½ out |
| » Lost to Tigers (84-54), 6-0 | Memorial Stadium (29-43) | 62-77 | Lost 3 |
| » W: Doyle Alexander (10-10) L: Mike Boddicker (10-8) | Sixth | 22½ out |
| Thursday, September 10 |
| » Lost to Red Sox (67-72), 5-4 | Fenway Park (0-4) | 62-78 | Lost 4 |
| » W: Joe Sambito (2-4) L: Tom Niedenfuer (4-4) S: Wes Gardner (10) | Sixth | 22½ out |
| » Major-league debuts: Jose Mesa (Orioles) |
| Friday, September 11 |
| » Lost to Red Sox (68-72), 9-3 | Fenway Park (0-5) | 62-79 | Lost 5 |
| » W: Jeff Sellers (7-7) L: John Habyan (4-5) | Fifth | 22½ out |
| Saturday, September 12 |
| » Lost to Red Sox (69-72), 4-3 | Fenway Park (0-6) | 62-80 | Lost 6 |
| » W: Bruce Hurst (15-10) L: Tom Niedenfuer (4-5) | Sixth | 23½ out |
| » Major-league debuts: Jody Reed (Red Sox) |
| Monday, September 14 |
| » Lost to Blue Jays (86-57), 18-3 | Exhibition Stadium (0-4) | 62-81 | Lost 7 |
| » W: Jim Clancy (13-10) L: Ken Dixon (7-10) | Fifth | 24 out |
| Tuesday, September 15 |
| » Lost to Blue Jays (87-57), 6-2 | Exhibition Stadium (0-5) | 62-82 | Lost 8 |
| » W: Mike Flanagan (5-6) L: Jose Mesa (0-1) | Fifth | 25 out |
| Wednesday, September 16 |
| » Lost to Blue Jays (88-57), 7-0 | Exhibition Stadium (0-6) | 62-83 | Lost 9 |
| » W: Jimmy Key (17-6) L: Mike Boddicker (10-9) | Fifth | 26 out |
| Friday, September 18 |
| » Defeated Red Sox (69-76), 9-4 | Memorial Stadium (30-43) | 63-83 | |
| » W: John Habyan (5-5) L: Bruce Hurst (15-11) S: Jack O'Connor (2) | Fifth | 26½ out |
| » Lost to Red Sox (70-76), 10-7 | Memorial Stadium (30-44) | 63-84 | |
| » W: Rob Woodward (1-0) L: Jeff Ballard (2-6) | Fifth | 26½ out |
| Sunday, September 20 |
| » Lost to Red Sox (71-76), 5-1 | Memorial Stadium (30-45) | 63-85 | Lost 2 |
| » W: Roger Clemens (17-9) L: Jose Mesa (0-2) | Fifth | 27½ out |
| » Lost to Red Sox (72-76), 6-3 | Memorial Stadium (30-46) | 63-86 | Lost 3 |
| » W: Wes Gardner (2-6) L: Luis DeLeon (0-2) | Fifth | 27½ out |
| Monday, September 21 |
| » Lost to Blue Jays (91-59), 2-1 | Memorial Stadium (30-47) | 63-87 | |