| Monday, April 6 |
| » Major-league debuts: Mike Sharperson (Blue Jays) |
| Tuesday, April 7 |
| » Lost to Angels (1-0), 7-1 | Anaheim Stadium (0-1) | 0-1 | |
| » W: Mike Witt (1-0) L: Mark Langston (0-1) | Second | 1 out |
| » Major-league debuts: Donell Nixon (Mariners) |
| Wednesday, April 8 |
| » Lost to Angels (2-0), 7-1 | Anaheim Stadium (0-2) | 0-2 | Lost 2 |
| » W: John Candelaria (1-0) L: Mike Moore (0-1) | Third | 2 out |
| Thursday, April 9 |
| » Defeated Angels (2-1), 7-2 | Anaheim Stadium (1-2) | 1-2 | |
| » W: Scott Bankhead (1-0) L: Don Sutton (0-1) S: Steve Shields (1) | Third | 2 out |
| Friday, April 10 |
| » Lost to Twins (4-0), 8-1 | Kingdome (0-1) | 1-3 | |
| » W: Mike Smithson (1-0) L: Mike Morgan (0-1) | Fourth | 3 out |
| Saturday, April 11 |
| » Defeated Twins (4-1), 6-5 | Kingdome (1-1) | 2-3 | |
| » W: Ed Nunez (1-0) L: Jeff Reardon (0-1) | Second | 2 out |
| » Major-league debuts: Les Straker (Twins) |
| Sunday, April 12 |
| » Lost to Twins (5-1), 8-5 | Kingdome (1-2) | 2-4 | |
| » W: Bert Blyleven (1-0) L: Mark Langston (0-2) S: Juan Berenguer (1) | Fourth | 3 out |
| Monday, April 13 |
| » Lost to Angels (5-2), 5-3 | Kingdome (1-3) | 2-5 | Lost 2 |
| » W: Donnie Moore (1-0) L: Ed Nunez (1-1) | Fourth | 3 out |
| Tuesday, April 14 |
| » Defeated Angels (5-3), 6-4 | Kingdome (2-3) | 3-5 | |
| » W: Scott Bankhead (2-0) L: Don Sutton (0-2) S: Ed Nunez (1) | Fourth | 3 out |
| Wednesday, April 15 |
| » Lost to Angels (6-3), 4-0 | Kingdome (2-4) | 3-6 | |
| » W: Kirk McCaskill (2-0) L: Mike Morgan (0-2) | Fifth | 4 out |
| » Major-league debuts: Rich Monteleone (Mariners) |
| Thursday, April 16 |
| » Defeated Athletics (2-8), 6-5 | Kingdome (3-4) | 4-6 | |
| » W: Mike Trujillo (1-0) L: Jose Rijo (0-1) S: Ed Nunez (2) | Fourth | 3½ out |
| Friday, April 17 |
| » Defeated Athletics (2-9), 4-2 | Kingdome (4-4) | 5-6 | Won 2 |
| » W: Mark Langston (1-2) L: Curt Young (1-1) | Third | 2½ out |
| Saturday, April 18 |
| » Lost to Athletics (3-9), 7-5 | Kingdome (4-5) | 5-7 | |
| » W: Jay Howell (2-1) L: Mike Moore (0-2) | Fourth | 3½ out |
| Sunday, April 19 |
| » Defeated Athletics (3-10), 8-1 | Kingdome (5-5) | 6-7 | |
| » W: Scott Bankhead (3-0) L: Chris Codiroli (0-2) | Second | 2½ out |
| Monday, April 20 |
| » Lost to Twins (9-4), 13-5 | Hubert H. Humphrey Metrodome (0-1) | 6-8 | |
| » W: Mike Smithson (3-0) L: Mike Morgan (0-3) | Fourth | 3½ out |
| Tuesday, April 21 |
| » Lost to Twins (10-4), 6-1 | Hubert H. Humphrey Metrodome (0-2) | 6-9 | Lost 2 |
| » W: Les Straker (1-0) L: Mike Trujillo (1-1) | Fourth | 4½ out |
| Wednesday, April 22 |
| » Defeated Twins (10-5), 4-3 | Hubert H. Humphrey Metrodome (1-2) | 7-9 | |
| » W: Mark Langston (2-2) L: George Frazier (1-2) | Third | 3½ out |
| Friday, April 24 |
| » Defeated Athletics (5-12), 6-3 | Oakland-Alameda County Stadium (1-0) | 8-9 | Won 2 |
| » W: Mike Moore (1-2) L: Bill Krueger (0-3) | Third | 3 out |
| Saturday, April 25 |
| » Lost to Athletics (6-12), 7-3 | Oakland-Alameda County Stadium (1-1) | 8-10 | |
| » W: Dave Stewart (2-2) L: Scott Bankhead (3-1) S: Dennis Eckersley (1) | Second | 3 out |
| Sunday, April 26 |
| » Defeated Athletics (6-13), 8-5 | Oakland-Alameda County Stadium (2-1) | 9-10 | |
| » W: Mike Trujillo (2-1) L: Jose Rijo (0-2) S: Ed Nunez (3) | Third | 3 out |
| Monday, April 27 |
| » Defeated Tigers (7-11), 5-2 | Kingdome (6-5) | 10-10 | Won 2 |
| » W: Mark Langston (3-2) L: Eric King (1-1) S: Ed Nunez (4) | Third | 2½ out |
| Tuesday, April 28 |
| » Defeated Tigers (7-12), 6-4 | Kingdome (7-5) | 11-10 | Won 3 |
| » W: Mike Morgan (1-3) L: Jeff Robinson (1-1) S: Ed Nunez (5) | Third | 1½ out |
| Wednesday, April 29 |
| » Lost to Red Sox (9-12), 11-5 | Kingdome (7-6) | 11-11 | |
| » W: Al Nipper (3-0) L: Mike Moore (1-3) | Third | 1½ out |
| Thursday, April 30 |
| » Defeated Red Sox (9-13), 11-2 | Kingdome (8-6) | 12-11 | |
| » W: Scott Bankhead (4-1) L: Bruce Hurst (2-3) | Second | 1 out |
| » Major-league debuts: Ellis Burks (Red Sox) |
| Friday, May 1 |
| » Lost to Brewers (19-3), 10-8 | Kingdome (8-7) | 12-12 | |
| » W: Paul Mirabella (2-0) L: Bill Wilkinson (0-1) S: Dan Plesac (8) | Second | 2 out |
| Saturday, May 2 |
| » Lost to Brewers (20-3), 6-4 | Kingdome (8-8) | 12-13 | Lost 2 |
| » W: Mark Clear (3-0) L: Mark Langston (3-3) S: Dan Plesac (9) | Third | 2 out |
| Sunday, May 3 |
| » Defeated Brewers (20-4), 7-3 | Kingdome (9-8) | 13-13 | |
| » W: Mike Morgan (2-3) L: Teddy Higuera (4-1) | Fourth | 2 out |
| Tuesday, May 5 |
| » Defeated Tigers (9-16), 7-5 | Tiger Stadium (1-0) | 14-13 | Won 2 |
| » W: Stan Clarke (1-0) L: Jeff Robinson (1-2) S: Ed Nunez (6) | Fourth | 1 out |
| Wednesday, May 6 |
| » Lost to Tigers (10-16), 7-5 | Tiger Stadium (1-1) | 14-14 | |
| » W: Walt Terrell (2-3) L: Scott Bankhead (4-2) S: Mark Thurmond (2) | Fourth | 2 out |
| Friday, May 8 |
| » Defeated Brewers (20-7), 4-3 | County Stadium (1-0) | 15-14 | |
| » W: Stan Clarke (2-0) L: Chris Bosio (3-1) S: Bill Wilkinson (1) | Fourth | 2 out |
| Saturday, May 9 |
| » Defeated Brewers (20-8), 8-2 | County Stadium (2-0) | 16-14 | Won 2 |
| » W: Mike Morgan (3-3) L: Juan Nieves (2-1) | Fourth | 2 out |
| Sunday, May 10 |
| » Defeated Brewers (20-9), 5-1 | County Stadium (3-0) | 17-14 | Won 3 |
| » W: Mike Moore (2-3) L: Bill Wegman (2-3) | Second | 2 out |
| Monday, May 11 |
| » Defeated Red Sox (14-17), 4-3 | Fenway Park (1-0) | 18-14 | Won 4 |
| » W: Scott Bankhead (5-2) L: Roger Clemens (2-3) S: Ed Nunez (7) | First | -- |
| Tuesday, May 12 |
| » Lost to Red Sox (15-17), 3-2 | Fenway Park (1-1) | 18-15 | |
| » W: Jeff Sellers (2-1) L: Mike Trujillo (2-2) S: Wes Gardner (3) | Second | 2 out |
| Wednesday, May 13 |
| » Defeated Red Sox (15-18), 5-4 | Fenway Park (2-1) | 19-15 | |
| » W: Mark Langston (4-3) L: Joe Sambito (1-1) S: Steve Shields (2) | Second | 2 out |
| Friday, May 15 |
| » Lost to Yankees (23-12), 7-3 | Kingdome (9-9) | 19-16 | |
| » W: Charles Hudson (6-0) L: Mike Morgan (3-4) S: Dave Righetti (9) | Second | 1½ out |
| Saturday, May 16 |
| » Defeated Yankees (23-13), 10-8 | Kingdome (10-9) | 20-16 | |
| » W: Steve Shields (1-0) L: Cecilio Guante (3-2) | Second | 1½ out |
| Sunday, May 17 |
| » Lost to Yankees (24-13), 8-3 | Kingdome (10-10) | 20-17 | |
| » W: Joe Niekro (2-2) L: Mike Moore (2-4) S: Dave Righetti (10) | Second | 1½ out |
| Monday, May 18 |
| » Lost to Orioles (19-19), 6-0 | Kingdome (10-11) | 20-18 | Lost 2 |
| » W: Mike Boddicker (3-1) L: Mark Langston (4-4) | Second | 2½ out |
| Tuesday, May 19 |
| » Lost to Orioles (20-19), 15-4 | Kingdome (10-12) | 20-19 | Lost 3 |
| » W: Jeff Ballard (1-0) L: Mike Trujillo (2-3) | Second | 3½ out |
| Wednesday, May 20 |
| » Defeated Orioles (20-20), 6-2 | Kingdome (11-12) | 21-19 | |
| » W: Mike Morgan (4-4) L: Ken Dixon (3-3) | Second | 2½ out |
| Friday, May 22 |
| » Lost to Blue Jays (23-16), 7-5 | Kingdome (11-13) | 21-20 | |
| » W: Mark Eichhorn (5-2) L: Scott Bankhead (5-3) S: Tom Henke (7) | Second | 3½ out |
| Saturday, May 23 |
| » Lost to Blue Jays (24-16), 6-2 | Kingdome (11-14) | 21-21 | Lost 2 |
| » W: Jim Clancy (7-2) L: Mike Moore (2-5) | Second | 3½ out |
| Sunday, May 24 |
| » Defeated Blue Jays (24-17), 5-2 | Kingdome (12-14) | 22-21 | |
| » W: Mark Langston (5-4) L: Dave Stieb (2-3) | Second | 3½ out |
| Monday, May 25 |
| » Lost to Blue Jays (25-17), 6-5 | Kingdome (12-15) | 22-22 | |
| » W: Jimmy Key (6-3) L: Mike Morgan (4-5) S: Jeff Musselman (1) | Second | 4½ out |
| Tuesday, May 26 |
| » Major-league debuts: Chuck Jackson (Astros) |
| Wednesday, May 27 |
| » Defeated Yankees (29-16), 6-5 | Yankee Stadium (1-0) | 23-22 | |
| » W: Lee Guetterman (1-0) L: Ron Guidry (0-1) S: Mike Trujillo (1) | Second | 4 out |
| Thursday, May 28 |
| » Lost to Yankees (30-16), 5-2 | Yankee Stadium (1-1) | 23-23 | |
| » W: Rick Rhoden (6-3) L: Mike Moore (2-6) S: Dave Righetti (12) | Third | 4½ out |
| Friday, May 29 |
| » Defeated Orioles (26-21), 7-3 | Memorial Stadium (1-0) | 24-23 | |
| » W: Mark Langston (6-4) L: Jeff Ballard (2-1) | Second | 3½ out |
| Saturday, May 30 |
| » Defeated Orioles (26-22), 12-0 | Memorial Stadium (2-0) | 25-23 | Won 2 |
| » W: Mike Morgan (5-5) L: Eric Bell (5-2) | Second | 3½ out |
| Sunday, May 31 |
| » Defeated Orioles (26-23), 8-5 | Memorial Stadium (3-0) | 26-23 | Won 3 |
| » W: Lee Guetterman (2-0) L: John Habyan (1-1) | Second | 2½ out |
| Monday, June 1 |
| » Defeated Blue Jays (28-20), 2-0 | Exhibition Stadium (1-0) | 27-23 | Won 4 |
| » W: Scott Bankhead (6-3) L: Joe Johnson (2-5) S: Bill Wilkinson (2) | Second | 1½ out |
| Tuesday, June 2 |
| » Lost to Blue Jays (29-20), 4-3 | Exhibition Stadium (1-1) | 27-24 | |
| » W: Jeff Musselman (3-1) L: Mike Moore (2-7) S: Tom Henke (9) | Second | 1½ out |
| Wednesday, June 3 |
| » Lost to Blue Jays (30-20), 7-2 | Exhibition Stadium (1-2) | 27-25 | Lost 2 |
| » W: Dave Stieb (4-3) L: Mark Langston (6-5) S: Mark Eichhorn (3) | Second | 1½ out |
| Thursday, June 4 |
| » Lost to Royals (28-22), 6-1 | Kingdome (12-16) | 27-26 | Lost 3 |
| » W: Bret Saberhagen (10-1) L: Mike Morgan (5-6) | Fourth | 2½ out |
| Friday, June 5 |
| » Defeated Royals (28-23), 7-2 | Kingdome (13-16) | 28-26 | |
| » W: Lee Guetterman (3-0) L: Danny Jackson (2-7) S: Steve Shields (3) | Second | 1½ out |
| Saturday, June 6 |
| » Lost to Royals (29-23), 5-2 | Kingdome (13-17) | 28-27 | |
| » W: Charlie Leibrandt (7-4) L: Scott Bankhead (6-4) S: Dan Quisenberry (7) | Third | 2½ out |
| Sunday, June 7 |
| » Lost to Royals (30-23), 9-1 | Kingdome (13-18) | 28-28 | Lost 2 |
| » W: Buddy Black (3-2) L: Mike Moore (2-8) | Fourth | 3½ out |
| Monday, June 8 |
| » Defeated Rangers (22-31), 6-0 | Kingdome (14-18) | 29-28 | |
| » W: Mark Langston (7-5) L: Mike Jeffcoat (0-1) | Third | 2½ out |
| Tuesday, June 9 |
| » Lost to Rangers (23-31), 3-0 | Kingdome (14-19) | 29-29 | |
| » W: Jose Guzman (4-5) L: Mike Morgan (5-7) S: Dale Mohorcic (5) | Fourth | 2½ out |
| Wednesday, June 10 |
| » Lost to Rangers (24-31), 9-5 | Kingdome (14-20) | 29-30 | Lost 2 |
| » W: Mitch Williams (4-3) L: Bill Wilkinson (0-2) S: Dale Mohorcic (6) | Fourth | 3½ out |
| Friday, June 12 |
| » Lost to Indians (21-38), 10-6 | Kingdome (14-21) | 29-31 | Lost 3 |
| » W: Mark Huismann (1-3) L: Mike Trujillo (2-4) | Fourth | 5 out |
| Saturday, June 13 |
| » Lost to Indians (22-38), 6-1 | Kingdome (14-22) | 29-32 | Lost 4 |
| » W: Phil Niekro (5-5) L: Mark Langston (7-6) | Fourth | 5 out |
| Sunday, June 14 |
| » Defeated Indians (22-39), 4-3 | Kingdome (15-22) | 30-32 | |
| » W: Ed Nunez (2-1) L: Rich Yett (1-5) | Fourth | 5 out |
| Monday, June 15 |
| » Defeated White Sox (23-37), 8-2 | Kingdome (16-22) | 31-32 | Won 2 |
| » W: Lee Guetterman (4-0) L: Floyd Bannister (3-6) S: Jerry Reed (1) | Fourth | 5 out |
| Tuesday, June 16 |
| » Defeated White Sox (23-38), 8-6 | Kingdome (17-22) | 32-32 | Won 3 |
| » W: Bill Wilkinson (1-2) L: Jim Winn (2-2) | Fourth | 5 out |
| Wednesday, June 17 |
| » Defeated White Sox (23-39), 2-0 | Kingdome (18-22) | 33-32 | Won 4 |
| » W: Scott Bankhead (7-4) L: Bill Long (3-3) S: Ed Nunez (8) | Fourth | 4 out |
| Friday, June 19 |
| » Defeated Indians (24-41), 7-4 | Cleveland Stadium (1-0) | 34-32 | Won 5 |
| » W: Mark Langston (8-6) L: Phil Niekro (5-6) | Third | 4 out |
| Saturday, June 20 |
| » Lost to Indians (25-41), 9-2 | Cleveland Stadium (1-1) | 34-33 | |
| » W: Steve Carlton (5-4) L: Mike Morgan (5-8) | Fourth | 4 out |
| Sunday, June 21 |
| » Defeated Indians (25-42), 5-0 | Cleveland Stadium (2-1) | 35-33 | |
| » W: Lee Guetterman (5-0) L: Ken Schrom (4-6) | Fourth | 4 out |
| Monday, June 22 |
| » Defeated White Sox (24-42), 3-0 | Comiskey Park I (1-0) | 36-33 | Won 2 |
| » W: Mike Moore (3-8) L: Scott Nielsen (0-2) S: Bill Wilkinson (3) | Third | 3½ out |
| Tuesday, June 23 |
| » Lost to White Sox (25-42), 13-3 | Comiskey Park I (1-1) | 36-34 | |
| » W: Bill Long (4-3) L: Scott Bankhead (7-5) | Fourth | 4½ out |
| Wednesday, June 24 |
| » Defeated White Sox (25-43), 10-7 | Comiskey Park I (2-1) | 37-34 | |
| » W: Mark Langston (9-6) L: Richard Dotson (4-5) S: Ed Nunez (9) | Fourth | 4½ out |
| Friday, June 26 |
| » Defeated Royals (36-34), 5-1 | Royals Stadium (1-0) | 38-34 | Won 2 |
| » W: Mike Morgan (6-8) L: Charlie Leibrandt (8-5) S: Bill Wilkinson (4) | Third | 4 out |
| Saturday, June 27 |
| » Lost to Royals (37-34), 6-0 | Royals Stadium (1-1) | 38-35 | |
| » W: Bret Saberhagen (13-2) L: Lee Guetterman (5-1) | Third | 3½ out |
| Sunday, June 28 |
| » Lost to Royals (38-34), 8-3 | Royals Stadium (1-2) | 38-36 | Lost 2 |
| » W: Mark Gubicza (6-8) L: Mike Moore (3-9) | Fourth | 3½ out |
| Monday, June 29 |
| » Lost to Rangers (35-38), 4-3 | Arlington Stadium (0-1) | 38-37 | Lost 3 |
| » W: Mitch Williams (5-3) L: Stan Clarke (2-1) | Fourth | 3½ out |
| Tuesday, June 30 |
| » Defeated Rangers (35-39), 5-2 | Arlington Stadium (1-1) | 39-37 | |
| » W: Mark Langston (10-6) L: Mike Loynd (1-4) | Fourth | 3½ out |
| Wednesday, July 1 |
| » Lost to Rangers (36-39), 7-3 | Arlington Stadium (1-2) | 39-38 | |
| » W: Charlie Hough (9-3) L: Mike Morgan (6-9) | Fourth | 3½ out |
| Thursday, July 2 |
| » Defeated Tigers (41-34), 5-2 | Kingdome (19-22) | 40-38 | |
| » W: Lee Guetterman (6-1) L: Frank Tanana (7-5) | Fourth | 2½ out |
| Friday, July 3 |
| » Lost to Tigers (42-34), 5-2 | Kingdome (19-23) | 40-39 | |
| » W: Jeff Robinson (5-4) L: Mike Moore (3-10) S: Eric King (6) | Fourth | 3½ out |
| Saturday, July 4 |
| » Lost to Tigers (43-34), 7-3 | Kingdome (19-24) | 40-40 | Lost 2 |
| » W: Jack Morris (12-3) L: Mike Campbell (0-1) | Fourth | 4½ out |
| » Major-league debuts: Mike Campbell (Mariners) |
| Sunday, July 5 |
| » Lost to Tigers (44-34), 7-5 | Kingdome (19-25) | 40-41 | Lost 3 |
| » W: Dan Petry (6-4) L: Mark Langston (10-7) S: Mike Henneman (2) | Fifth | 5½ out |
| Monday, July 6 |
| » Defeated Brewers (40-39), 3-2 | Kingdome (20-25) | 41-41 | |
| » W: Mike Morgan (7-9) L: Bill Wegman (7-8) S: Ed Nunez (10) | Fifth | 5½ out |
| Tuesday, July 7 |
| » Defeated Brewers (40-40), 9-5 | Kingdome (21-25) | 42-41 | Won 2 |
| » W: Lee Guetterman (7-1) L: Juan Nieves (5-6) S: Jerry Reed (2) | Fifth | 4½ out |
| Wednesday, July 8 |
| » Defeated Brewers (40-41), 5-2 | Kingdome (22-25) | 43-41 | Won 3 |
| » W: Bill Wilkinson (2-2) L: Dan Plesac (4-1) | Fifth | 3½ out |
| Thursday, July 9 |
| » Defeated Red Sox (39-46), 11-5 | Kingdome (23-25) | 44-41 | Won 4 |
| » W: Roy Thomas (1-0) L: Wes Gardner (0-5) | Fifth | 3½ out |
| Friday, July 10 |
| » Lost to Red Sox (40-46), 7-4 | Kingdome (23-26) | 44-42 | |
| » W: Calvin Schiraldi (5-4) L: Mark Langston (10-8) | Fourth | 3½ out |
| Saturday, July 11 |
| » Lost to Red Sox (41-46), 10-4 | Kingdome (23-27) | 44-43 | Lost 2 |
| » W: Roger Clemens (8-6) L: Mike Morgan (7-10) | Fourth | 4½ out |
| Sunday, July 12 |
| » Defeated Red Sox (41-47), 6-1 | Kingdome (24-27) | 45-43 | |
| » W: Lee Guetterman (8-1) L: Al Nipper (7-9) S: Jerry Reed (3) | Fourth | 3½ out |
| Thursday, July 16 |
| » Lost to Tigers (49-37), 3-2 | Tiger Stadium (1-2) | 45-44 | |
| » W: Walt Terrell (7-8) L: Mike Moore (3-11) | Fifth | 3½ out |
| Friday, July 17 |
| » Lost to Tigers (50-37), 7-0 | Tiger Stadium (1-3) | 45-45 | Lost 2 |
| » W: Frank Tanana (9-6) L: Mark Langston (10-9) | Fifth | 4½ out |
| Saturday, July 18 |
| » Lost to Tigers (51-37), 10-6 | Tiger Stadium (1-4) | 45-46 | Lost 3 |
| » W: Mike Henneman (5-0) L: Jerry Reed (0-1) S: Eric King (7) | Fifth | 4½ out |
| Sunday, July 19 |
| » Defeated Tigers (51-38), 5-4 | Tiger Stadium (2-4) | 46-46 | |
| » W: Ed Nunez (3-1) L: Guillermo Hernandez (1-2) | Fifth | 4½ out |
| Monday, July 20 |
| » Lost to Brewers (45-45), 13-11 | County Stadium (3-1) | 46-47 | |
| » W: Chuck Crim (4-5) L: Mike Morgan (7-11) S: Mark Clear (3) | Fifth | 4½ out |
| Tuesday, July 21 |
| » Lost to Brewers (46-45), 6-4 | County Stadium (3-2) | 46-48 | Lost 2 |
| » W: Teddy Higuera (9-7) L: Mike Moore (3-12) | Fifth | 5½ out |
| Wednesday, July 22 |
| » Defeated Brewers (46-46), 2-1 | County Stadium (4-2) | 47-48 | |
| » W: Mark Langston (11-9) L: Bill Wegman (8-9) | Fifth | 5½ out |
| Friday, July 24 |
| » Lost to Red Sox (44-52), 5-4 | Fenway Park (2-2) | 47-49 | |
| » W: Bruce Hurst (11-6) L: Lee Guetterman (8-2) | Fifth | 5 out |
| Saturday, July 25 |
| » Lost to Red Sox (45-52), 11-5 | Fenway Park (2-3) | 47-50 | Lost 2 |
| » W: Tom Bolton (1-0) L: Stan Clarke (2-2) | Sixth | 6 out |
| » Major-league debuts: Sam Horn (Red Sox) |
| Sunday, July 26 |
| » Lost to Red Sox (46-52), 11-1 | Fenway Park (2-4) | 47-51 | Lost 3 |
| » W: Roger Clemens (10-7) L: Mike Moore (3-13) | Sixth | 6 out |
| Monday, July 27 |
| » Lost to Twins (55-46), 4-3 | Kingdome (24-28) | 47-52 | Lost 4 |
| » W: Frank Viola (11-6) L: Ed Nunez (3-2) S: Jeff Reardon (21) | Fifth | 7 out |
| Tuesday, July 28 |
| » Defeated Twins (55-47), 6-1 | Kingdome (25-28) | 48-52 | |
| » W: Mike Morgan (8-11) L: Joe Niekro (5-8) | Fifth | 6 out |
| Wednesday, July 29 |
| » Defeated Twins (55-48), 8-3 | Kingdome (26-28) | 49-52 | Won 2 |
| » W: Lee Guetterman (9-2) L: Mike Smithson (4-6) | Fifth | 5 out |
| Friday, July 31 |
| » Lost to Angels (53-50), 8-2 | Anaheim Stadium (1-3) | 49-53 | |
| » W: Jack Lazorko (4-5) L: Scott Bankhead (7-6) S: Greg Minton (10) | Fifth | 6 out |
| Saturday, August 1 |
| » Lost to Angels (54-50), 4-3 | Anaheim Stadium (1-4) | 49-54 | Lost 2 |
| » W: Willie Fraser (7-7) L: Mike Moore (3-14) S: DeWayne Buice (12) | Sixth | 6 out |
| Sunday, August 2 |
| » Defeated Angels (54-51), 5-4 | Anaheim Stadium (2-4) | 50-54 | |
| » W: Steve Shields (2-0) L: Greg Minton (4-2) | Sixth | 5 out |
| Monday, August 3 |
| » Defeated Athletics (54-51), 4-3 | Oakland-Alameda County Stadium (3-1) | 51-54 | Won 2 |
| » W: Mike Morgan (9-11) L: Joaquin Andujar (3-5) S: Ed Nunez (11) | Fifth | 5 out |
| Tuesday, August 4 |
| » Lost to Athletics (55-51), 9-3 | Oakland-Alameda County Stadium (3-2) | 51-55 | |
| » W: Steve Ontiveros (6-5) L: Lee Guetterman (9-3) | Fifth | 5 out |
| Wednesday, August 5 |
| » Lost to Athletics (56-51), 3-1 | Oakland-Alameda County Stadium (3-3) | 51-56 | Lost 2 |
| » W: Jose Rijo (2-5) L: Scott Bankhead (7-7) S: Gene Nelson (2) | Sixth | 5 out |
| Thursday, August 6 |
| » Defeated Angels (56-53), 15-4 | Kingdome (27-28) | 52-56 | |
| » W: Mike Moore (4-14) L: Willie Fraser (7-8) | Sixth | 5 out |
| Friday, August 7 |
| » Defeated Angels (56-54), 14-0 | Kingdome (28-28) | 53-56 | Won 2 |
| » W: Mark Langston (12-9) L: Kirk McCaskill (2-4) | Fifth | 5 out |
| Saturday, August 8 |
| » Defeated Angels (56-55), 5-3 | Kingdome (29-28) | 54-56 | Won 3 |
| » W: Mike Morgan (10-11) L: Mike Witt (13-8) S: Bill Wilkinson (5) | Fourth | 5 out |
| Sunday, August 9 |
| » Lost to Angels (57-55), 7-5 | Kingdome (29-29) | 54-57 | |
| » W: DeWayne Buice (5-3) L: Dennis Powell (0-1) | Fifth | 6 out |
| Monday, August 10 |
| » Lost to Athletics (57-55), 15-4 | Kingdome (29-30) | 54-58 | Lost 2 |
| » W: Dave Stewart (15-8) L: Scott Bankhead (7-8) | Fourth | 6½ out |
| Tuesday, August 11 |
| » Defeated Athletics (57-56), 8-2 | Kingdome (30-30) | 55-58 | |
| » W: Mike Moore (5-14) L: Jose Rijo (2-6) | Fourth | 6½ out |
| Wednesday, August 12 |
| » Defeated Athletics (57-57), 4-3 | Kingdome (31-30) | 56-58 | Won 2 |
| » W: Mark Langston (13-9) L: Gene Nelson (5-3) S: Bill Wilkinson (6) | Fifth | 5½ out |
| Friday, August 14 |
| » Lost to Twins (63-54), 6-3 | Hubert H. Humphrey Metrodome (1-3) | 56-59 | |
| » W: Bert Blyleven (12-9) L: Mike Morgan (10-12) | Fourth | 6 out |
| Saturday, August 15 |
| » Lost to Twins (64-54), 14-4 | Hubert H. Humphrey Metrodome (1-4) | 56-60 | Lost 2 |
| » W: Roy Smith (1-0) L: Lee Guetterman (9-4) | Fifth | 7 out |
| Sunday, August 16 |
| » Lost to Twins (65-54), 5-1 | Hubert H. Humphrey Metrodome (1-5) | 56-61 | Lost 3 |
| » W: Frank Viola (14-7) L: Mike Moore (5-15) | Fifth | 8 out |
| Monday, August 17 |
| » Lost to Twins (66-54), 4-2 | Hubert H. Humphrey Metrodome (1-6) | 56-62 | Lost 4 |
| » W: Les Straker (6-7) L: Mark Langston (13-10) S: Jeff Reardon (24) | Fifth | 9 out |
| Tuesday, August 18 |
| » Lost to Yankees (68-51), 4-3 | Kingdome (31-31) | 56-63 | Lost 5 |
| » W: Tim Stoddard (4-2) L: Bill Wilkinson (2-3) S: Dave Righetti (22) | Sixth | 9 out |
| Wednesday, August 19 |
| » Lost to Yankees (69-51), 8-0 | Kingdome (31-32) | 56-64 | Lost 6 |
| » W: Charles Hudson (8-3) L: Mike Morgan (10-13) | Sixth | 9 out |
| Thursday, August 20 |
| » Defeated Yankees (69-52), 4-3 | Kingdome (32-32) | 57-64 | |
| » W: Jerry Reed (1-1) L: Brad Arnsberg (1-3) | Sixth | 8 out |
| » Major-league debuts: Randy Velarde (Yankees) |
| Friday, August 21 |
| » Defeated Orioles (56-66), 3-2 | Kingdome (33-32) | 58-64 | Won 2 |
| » W: Mike Moore (6-15) L: Mike Flanagan (2-6) | Fifth | 7 out |
| Saturday, August 22 |
| » Defeated Orioles (56-67), 14-6 | Kingdome (34-32) | 59-64 | Won 3 |
| » W: Mark Langston (14-10) L: Dave J. Schmidt (10-5) | Fifth | 6 out |
| Sunday, August 23 |
| » Lost to Orioles (57-67), 6-5 | Kingdome (34-33) | 59-65 | |
| » W: Ken Dixon (7-8) L: Dennis Powell (0-2) | Fifth | 6 out |
| Monday, August 24 |
| » Lost to Blue Jays (74-51), 7-3 | Kingdome (34-34) | 59-66 | Lost 2 |
| » W: John Cerutti (10-3) L: Mike Morgan (10-14) | Sixth | 7 out |
| Tuesday, August 25 |
| » Lost to Blue Jays (75-51), 6-3 | Kingdome (34-35) | 59-67 | Lost 3 |
| » W: Jim Clancy (11-10) L: Mike Moore (6-16) S: Mark Eichhorn (4) | Sixth | 7 out |
| » Major-league debuts: Nelson Liriano (Blue Jays) |
| Friday, August 28 |
| » Defeated Yankees (71-56), 10-4 | Yankee Stadium (2-1) | 60-67 | |
| » W: Mike Trujillo (3-4) L: Charles Hudson (9-4) | Sixth | 5½ out |
| Saturday, August 29 |
| » Defeated Yankees (71-57), 7-1 | Yankee Stadium (3-1) | 61-67 | Won 2 |
| » W: Mark Langston (15-10) L: Rick Rhoden (15-9) | Fifth | 6 out |
| » Lost to Yankees (72-57), 4-2 | Yankee Stadium (3-2) | 61-68 | |
| » W: Tommy John (12-4) L: Mike Campbell (0-2) S: Dave Righetti (24) | Fifth | 6 out |
| Sunday, August 30 |
| » Lost to Yankees (73-57), 4-1 | Yankee Stadium (3-3) | 61-69 | Lost 2 |
| » W: Bill Gullickson (11-11) L: Mike Moore (6-17) S: Dave Righetti (25) | Fifth | 7 out |
| Monday, August 31 |
| » Lost to Orioles (60-71), 4-3 | Memorial Stadium (3-1) | 61-70 | Lost 3 |
| » W: Mike Griffin (3-5) L: Mike Morgan (10-15) S: Tom Niedenfuer (11) | Sixth | 7½ out |
| Tuesday, September 1 |
| » Defeated Orioles (60-72), 5-0 | Memorial Stadium (4-1) | 62-70 | |
| » W: Scott Bankhead (8-8) L: John Habyan (4-4) | Sixth | 6½ out |
| Wednesday, September 2 |
| » Defeated Orioles (60-73), 8-6 | Memorial Stadium (5-1) | 63-70 | Won 2 |
| » W: Mark Langston (16-10) L: Jeff Ballard (2-4) S: Jerry Reed (4) | Fifth | 6½ out |
| Friday, September 4 |
| » Lost to Blue Jays (80-54), 6-5 | Exhibition Stadium (1-3) | 63-71 | |
| » W: Jose Nunez (3-1) L: Dennis Powell (0-3) | Fourth | 8 out |
| Saturday, September 5 |
| » Lost to Blue Jays (81-54), 3-0 | Exhibition Stadium (1-4) | 63-72 | Lost 2 |
| » W: Mike Flanagan (4-6) L: Mike Campbell (0-3) S: Tom Henke (31) | Fifth | 9 out |
| Sunday, September 6 |
| » Lost to Blue Jays (82-54), 3-2 | Exhibition Stadium (1-5) | 63-73 | Lost 3 |
| » W: Jose Nunez (4-1) L: Ed Nunez (3-3) | Fifth | 9 out |
| Monday, September 7 |
| » Defeated Indians (53-86), 6-4 | Cleveland Stadium (3-1) | 64-73 | |
| » W: Mark Langston (17-10) L: Tom Candiotti (7-15) S: Jerry Reed (5) | Fifth | 9 out |
| Tuesday, September 8 |
| » Defeated Indians (53-87), 7-0 | Cleveland Stadium (4-1) | 65-73 | Won 2 |
| » W: Mike Morgan (11-15) L: Rich Yett (3-7) | Fifth | 8 out |
| » Major-league debuts: Brian Dorsett (Indians) |
| Wednesday, September 9 |
| » Defeated Indians (53-88), 9-4 | Cleveland Stadium (5-1) | 66-73 | Won 3 |
| » W: Mike Moore (7-17) L: Jamie Easterly (1-1) | Fifth | 8 out |
| Friday, September 11 |
| » Lost to White Sox (60-80), 5-1 | Kingdome (34-36) | 66-74 | |
| » W: Jose DeLeon (9-12) L: Mike Campbell (0-4) S: Bobby Thigpen (10) | Fifth | 9 out |
| Saturday, September 12 |
| » Defeated White Sox (60-81), 12-2 | Kingdome (35-36) | 67-74 | |
| » W: Scott Bankhead (9-8) L: Bill Long (8-8) | Fifth | 8 out |
| » Major-league debuts: Mario Diaz and Edgar Martinez (Mariners) |
| Sunday, September 13 |
| » Lost to White Sox (61-81), 2-0 | Kingdome (35-37) | 67-75 | |
| » W: Floyd Bannister (13-10) L: Mark Langston (17-11) | Fourth | 9 out |
| Monday, September 14 |
| » Lost to Indians (55-90), 11-8 | Kingdome (35-38) | 67-76 | Lost 2 |
| » W: Scott Bailes (7-8) L: Mike Morgan (11-16) S: Doug Jones (7) | Sixth | 9 out |
| » Major-league debuts: Clay Parker (Mariners) |
| Tuesday, September 15 |
| » Lost to Indians (56-90), 4-2 | Kingdome (35-39) | 67-77 | Lost 3 |
| » W: Ken Schrom (6-11) L: Mike Moore (7-18) | Fourth | 9 out |
| Wednesday, September 16 |
| » Defeated Indians (56-91), 5-3 | Kingdome (36-39) | 68-77 | |
| » W: Bill Wilkinson (3-3) L: Sammy Stewart (4-2) | Fourth | 8 out |
| Thursday, September 17 |
| » Lost to White Sox (65-81), 9-8 | Comiskey Park I (2-2) | 68-78 | |
| » W: Bobby Thigpen (5-4) L: Bill Wilkinson (3-4) | Sixth | 8½ out |
| Friday, September 18 |
| » Defeated White Sox (65-82), 1-0 | Comiskey Park I (3-2) | 69-78 | |
| » W: Mark Langston (18-11) L: Floyd Bannister (13-11) | Sixth | 8½ out |
| Saturday, September 19 |
| » Lost to White Sox (66-82), 10-8 | Comiskey Park I (3-3) | 69-79 | |
| » W: Bobby Thigpen (6-4) L: Ed Nunez (3-4) | Sixth | 9½ out |
| » Major-league debuts: Adam Peterson (White Sox) |
| Sunday, September 20 |
| » Lost to White Sox (67-82), 5-3 | Comiskey Park I (3-4) | 69-80 | Lost 2 |
| » W: Jack McDowell (2-0) L: Mike Moore (7-19) S: Bobby Thigpen (12) | Sixth | 10½ out |
| Monday, September 21 |
| » Defeated Royals (74-77), 5-1 | Kingdome (37-39) | 70-80 | |
| » W: Mike Campbell (1-4) L: Bret Saberhagen (17-10) | Fifth | 10 out |
| Tuesday, September 22 |
| » Lost to Royals (75-77), 4-3 | Kingdome (37-40) | 70-81 | |
| » W: Jerry Gleaton (4-4) L: Jerry Reed (1-2) S: Gene Garber (15) | Sixth | 11 out |
| Wednesday, September 23 |
| » Lost to Royals (76-77), 9-0 | Kingdome (37-41) | 70-82 | Lost 2 |
| » W: Mark Gubicza (12-17) L: Mark Langston (18-12) | Sixth | 12 out |
| Friday, September 25 |
| » Defeated Rangers (73-80), 12-3 | Kingdome (38-41) | 71-82 | |
| » W: Mike Morgan (12-16) L: Bobby Witt (7-10) | Fifth | 11½ out |
| Saturday, September 26 |
| » Defeated Rangers (73-81), 2-1 | Kingdome (39-41) | 72-82 | Won 2 |
| » W: Mike Moore (8-19) L: Paul Kilgus (2-7) S: Bill Wilkinson (7) | Fifth | 10½ out |
| Sunday, September 27 |
| » Defeated Rangers (73-82), 5-3 | Kingdome (40-41) | 73-82 | Won 3 |
| » W: Mike Trujillo (4-4) L: Mitch Williams (8-5) S: Ed Nunez (12) | Fourth | 10½ out |
| Monday, September 28 |
| » Defeated Royals (78-79), 5-1 | Royals Stadium (2-2) | 74-82 | Won 4 |
| » W: Lee Guetterman (10-4) L: Mark Gubicza (12-18) S: Jerry Reed (6) | Fourth | 10½ out |
| Tuesday, September 29 |
| » Lost to Royals (79-79), 6-3 | Royals Stadium (2-3) | 74-83 | |
| » W: Buddy Black (8-6) L: Mark Langston (18-13) | Fourth | 10½ out |
| Wednesday, September 30 |
| » Lost to Royals (80-79), 7-3 | Royals Stadium (2-4) | 74-84 | Lost 2 |
| » W: Danny Jackson (9-18) L: Mike Morgan (12-17) | Fifth | 10½ out |
| Thursday, October 1 |
| » Defeated Rangers (75-84), 8-6 | Arlington Stadium (2-2) | 75-84 | |
| » W: Mike Moore (9-19) L: Mitch Williams (8-6) S: Bill Wilkinson (8) | Third | 10 out |
| Friday, October 2 |
| » Defeated Rangers (75-85), 5-4 | Arlington Stadium (3-2) | 76-84 | Won 2 |
| » W: Dennis Powell (1-3) L: Dale Mohorcic (7-6) S: Bill Wilkinson (9) | Third | 9 out |
| Saturday, October 3 |
| » Defeated Rangers (75-86), 6-4 | Arlington Stadium (4-2) | 77-84 | Won 3 |
| » W: Lee Guetterman (11-4) L: Jose Guzman (14-14) S: Bill Wilkinson (10) | Fourth | 8 out |
| Sunday, October 4 |
| » Defeated Rangers (75-87), 7-4 | Arlington Stadium (5-2) | 78-84 | Won 4 |
| » W: Mark Langston (19-13) L: Charlie Hough (18-13) S: Jerry Reed (7) | Fourth | 7 out |
Game information provided by Retrosheet (www.retrosheet.org) |