| Monday, January 5 |
| Former Indian Dale Mitchell dies in Tulsa, OK at the age of 66. |
| Monday, April 6 |
| » Lost to Blue Jays (1-0), 7-3 | Exhibition Stadium (0-1) | 0-1 | |
| » W: Jimmy Key (1-0) L: Tom Candiotti (0-1) | Second | 1 out |
| » Major-league debuts: Mike Sharperson (Blue Jays) |
| Wednesday, April 8 |
| » Lost to Blue Jays (2-0), 5-1 | Exhibition Stadium (0-2) | 0-2 | Lost 2 |
| » W: Jim Clancy (1-0) L: Greg Swindell (0-1) | Third | 2 out |
| Thursday, April 9 |
| » Defeated Blue Jays (2-1), 14-3 | Exhibition Stadium (1-2) | 1-2 | |
| » W: Phil Niekro (1-0) L: Joe Johnson (0-1) S: Steve Carlton (1) | Third | 2 out |
| » Major-league debuts: Jose Nunez (Blue Jays) |
| Friday, April 10 |
| » Lost to Orioles (3-1), 12-11 | Cleveland Stadium (0-1) | 1-3 | |
| » W: Mark Williamson (1-1) L: Ernie Camacho (0-1) | Fourth | 3 out |
| Saturday, April 11 |
| » Lost to Orioles (4-1), 7-3 | Cleveland Stadium (0-2) | 1-4 | Lost 2 |
| » W: Dave J. Schmidt (1-0) L: Tom Candiotti (0-2) | Fourth | 4 out |
| Sunday, April 12 |
| » Lost to Orioles (5-1), 7-1 | Cleveland Stadium (0-3) | 1-5 | Lost 3 |
| » W: Eric Bell (1-0) L: Ken Schrom (0-1) | Sixth | 5 out |
| » Major-league debuts: Dave Gallagher (Indians) |
| Monday, April 13 |
| » Lost to Yankees (4-3), 11-3 | Yankee Stadium (0-1) | 1-6 | Lost 4 |
| » W: Charles Hudson (2-0) L: Greg Swindell (0-2) | Seventh | 6 out |
| Tuesday, April 14 |
| » Lost to Yankees (5-3), 10-6 | Yankee Stadium (0-2) | 1-7 | Lost 5 |
| » W: Cecilio Guante (1-0) L: Steve Carlton (0-1) | Fifth | 7 out |
| Wednesday, April 15 |
| » Lost to Yankees (6-3), 4-3 | Yankee Stadium (0-3) | 1-8 | Lost 6 |
| » W: Rick Rhoden (1-1) L: Tom Waddell (0-1) S: Dave Righetti (2) | Fifth | 8 out |
| Friday, April 17 |
| » Lost to Orioles (6-4), 4-1 | Memorial Stadium (0-1) | 1-9 | Lost 7 |
| » W: Mike Boddicker (1-0) L: Tom Candiotti (0-3) S: Mark Williamson (1) | Sixth | 9 out |
| Saturday, April 18 |
| » Lost to Orioles (7-4), 16-3 | Memorial Stadium (0-2) | 1-10 | Lost 8 |
| » W: Eric Bell (2-0) L: Ken Schrom (0-2) S: Dave J. Schmidt (1) | Seventh | 10 out |
| Sunday, April 19 |
| » Defeated Orioles (7-5), 3-0 | Memorial Stadium (1-2) | 2-10 | |
| » W: Greg Swindell (1-2) L: Scott McGregor (0-2) | Sixth | 9½ out |
| » Defeated Orioles (7-6), 8-7 | Memorial Stadium (2-2) | 3-10 | Won 2 |
| » W: Steve Carlton (1-1) L: Mark Williamson (1-2) S: Ernie Camacho (1) | Sixth | 9½ out |
| Monday, April 20 |
| » Lost to Blue Jays (7-6), 8-7 | Cleveland Stadium (0-4) | 3-11 | |
| » W: Jeff Musselman (1-0) L: Doug Jones (0-1) | Sixth | 10½ out |
| Tuesday, April 21 |
| » Defeated Blue Jays (7-7), 5-0 | Cleveland Stadium (1-4) | 4-11 | |
| » W: Tom Candiotti (1-3) L: Jimmy Key (3-1) | Fifth | 9½ out |
| Wednesday, April 22 |
| » Lost to Blue Jays (8-7), 6-3 | Cleveland Stadium (1-5) | 4-12 | |
| » W: Mark Eichhorn (2-0) L: Steve Carlton (1-2) S: Tom Henke (2) | Fifth | 10 out |
| Thursday, April 23 |
| » Lost to Yankees (13-3), 5-4 | Cleveland Stadium (1-6) | 4-13 | Lost 2 |
| » W: Dennis Rasmussen (2-0) L: Greg Swindell (1-3) S: Dave Righetti (6) | Sixth | 10½ out |
| Friday, April 24 |
| » Defeated Yankees (13-4), 6-5 | Cleveland Stadium (2-6) | 5-13 | |
| » W: Steve Carlton (2-2) L: Dave Righetti (2-1) | Seventh | 10½ out |
| Saturday, April 25 |
| » Defeated Yankees (13-5), 2-1 | Cleveland Stadium (3-6) | 6-13 | Won 2 |
| » W: Scott Bailes (1-0) L: Rick Rhoden (2-2) S: Frank Wills (1) | Seventh | 10½ out |
| Sunday, April 26 |
| » Lost to Yankees (14-5), 14-2 | Cleveland Stadium (3-7) | 6-14 | |
| » W: Tommy John (1-0) L: Tom Candiotti (1-4) | Seventh | 11½ out |
| Tuesday, April 28 |
| » Defeated White Sox (6-11), 1-0 | Cleveland Stadium (4-7) | 7-14 | |
| » W: Ken Schrom (1-2) L: Joel Davis (1-2) | Seventh | 11 out |
| Wednesday, April 29 |
| » Defeated White Sox (6-12), 6-5 | Cleveland Stadium (5-7) | 8-14 | Won 2 |
| » W: Rich Yett (1-0) L: Bob James (1-2) | Sixth | 11 out |
| Thursday, April 30 |
| » Major-league debuts: Ellis Burks (Red Sox) |
| Friday, May 1 |
| » Defeated Royals (9-11), 2-0 | Royals Stadium (1-0) | 9-14 | Won 3 |
| » W: Phil Niekro (2-0) L: Mark Gubicza (1-4) S: Rich Yett (1) | Sixth | 10½ out |
| Saturday, May 2 |
| » Lost to Royals (10-11), 5-4 | Royals Stadium (1-1) | 9-15 | |
| » W: Bret Saberhagen (5-0) L: Rich Yett (1-1) S: Dan Quisenberry (1) | Sixth | 11½ out |
| Sunday, May 3 |
| » Lost to Royals (11-11), 2-1 | Royals Stadium (1-2) | 9-16 | Lost 2 |
| » W: Danny Jackson (1-4) L: Ken Schrom (1-3) | Sixth | 11½ out |
| Tuesday, May 5 |
| » Lost to Rangers (9-14), 6-5 | Arlington Stadium (0-1) | 9-17 | Lost 3 |
| » W: Mitch Williams (3-2) L: Frank Wills (0-1) | Seventh | 11½ out |
| Wednesday, May 6 |
| » Lost to Rangers (10-14), 7-2 | Arlington Stadium (0-2) | 9-18 | Lost 4 |
| » W: Charlie Hough (2-1) L: Phil Niekro (2-1) | Seventh | 11½ out |
| Friday, May 8 |
| » Lost to Royals (14-11), 9-6 | Cleveland Stadium (5-8) | 9-19 | Lost 5 |
| » W: Mark Gubicza (2-4) L: Ken Schrom (1-4) S: Dan Quisenberry (2) | Seventh | 11½ out |
| Saturday, May 9 |
| » Lost to Royals (15-11), 4-0 | Cleveland Stadium (5-9) | 9-20 | Lost 6 |
| » W: Bret Saberhagen (6-0) L: Tom Candiotti (1-5) | Sixth | 11½ out |
| Sunday, May 10 |
| » Defeated Royals (15-12), 4-2 | Cleveland Stadium (6-9) | 10-20 | |
| » W: Greg Swindell (2-3) L: Danny Jackson (1-5) | Sixth | 10½ out |
| Monday, May 11 |
| » Lost to Rangers (12-16), 6-3 | Cleveland Stadium (6-10) | 10-21 | |
| » W: Ron Meridith (1-0) L: Phil Niekro (2-2) S: Mike Loynd (1) | Sixth | 11 out |
| Tuesday, May 12 |
| » Lost to Rangers (13-16), 6-1 | Cleveland Stadium (6-11) | 10-22 | Lost 2 |
| » W: Charlie Hough (3-1) L: Steve Carlton (2-3) | Sixth | 11 out |
| Wednesday, May 13 |
| » Defeated White Sox (10-20), 7-5 | Comiskey Park I (1-0) | 11-22 | |
| » W: Ken Schrom (2-4) L: Jose DeLeon (3-3) S: Scott Bailes (1) | Sixth | 10 out |
| Thursday, May 14 |
| » Lost to White Sox (11-20), 4-3 | Comiskey Park I (1-1) | 11-23 | |
| » W: Bobby Thigpen (2-2) L: Rich Yett (1-2) | Seventh | 11 out |
| Former Indian Luke Sewell dies in Akron, OH at the age of 87. |
| Friday, May 15 |
| » Lost to Tigers (14-19), 4-3 | Tiger Stadium (0-1) | 11-24 | Lost 2 |
| » W: Mike Henneman (1-0) L: Mark Huismann (0-1) | Seventh | 12 out |
| Saturday, May 16 |
| » Lost to Tigers (15-19), 5-3 | Tiger Stadium (0-2) | 11-25 | Lost 3 |
| » W: Jack Morris (4-2) L: Phil Niekro (2-3) | Seventh | 12 out |
| Sunday, May 17 |
| » Lost to Tigers (16-19), 8-4 | Tiger Stadium (0-3) | 11-26 | Lost 4 |
| » W: Walt Terrell (3-4) L: Steve Carlton (2-4) | Seventh | 13 out |
| Tuesday, May 19 |
| » Defeated Twins (19-19), 4-3 | Cleveland Stadium (7-11) | 12-26 | |
| » W: Ken Schrom (3-4) L: Mark Portugal (1-3) | Seventh | 12½ out |
| Wednesday, May 20 |
| » Lost to Twins (20-19), 8-2 | Cleveland Stadium (7-12) | 12-27 | |
| » W: Juan Berenguer (2-0) L: Tom Candiotti (1-6) | Seventh | 12½ out |
| Thursday, May 21 |
| » Defeated Twins (20-20), 6-3 | Cleveland Stadium (8-12) | 13-27 | |
| » W: Greg Swindell (3-3) L: Bert Blyleven (3-4) | Seventh | 12 out |
| » Major-league debuts: Gene Larkin (Twins) |
| Friday, May 22 |
| » Lost to Brewers (22-15), 4-2 | County Stadium (0-1) | 13-28 | |
| » W: Bill Wegman (3-4) L: Phil Niekro (2-4) S: Dan Plesac (10) | Seventh | 13 out |
| Saturday, May 23 |
| » Defeated Brewers (22-16), 6-2 | County Stadium (1-1) | 14-28 | |
| » W: Steve Carlton (3-4) L: Mike Birkbeck (1-3) | Seventh | 13 out |
| Sunday, May 24 |
| » Defeated Brewers (22-17), 5-3 | County Stadium (2-1) | 15-28 | Won 2 |
| » W: Ken Schrom (4-4) L: Teddy Higuera (4-4) S: Scott Bailes (2) | Seventh | 13 out |
| Monday, May 25 |
| » Lost to Red Sox (18-25), 10-6 | Fenway Park (0-1) | 15-29 | |
| » W: Steve Crawford (1-1) L: Mark Huismann (0-2) | Seventh | 14 out |
| Tuesday, May 26 |
| » Lost to Red Sox (19-25), 6-5 | Fenway Park (0-2) | 15-30 | Lost 2 |
| » W: Al Nipper (4-4) L: Greg Swindell (3-4) | Seventh | 14½ out |
| Wednesday, May 27 |
| » Lost to Red Sox (20-25), 1-0 | Fenway Park (0-3) | 15-31 | Lost 3 |
| » W: Roger Clemens (4-4) L: Phil Niekro (2-5) | Seventh | 14½ out |
| Thursday, May 28 |
| » Lost to Red Sox (21-25), 12-8 | Fenway Park (0-4) | 15-32 | Lost 4 |
| » W: Steve Crawford (2-1) L: Rich Yett (1-3) S: Wes Gardner (4) | Seventh | 15½ out |
| » Major-league debuts: John Leister (Red Sox) |
| Friday, May 29 |
| » Defeated Brewers (22-21), 9-6 | Cleveland Stadium (9-12) | 16-32 | |
| » W: Scott Bailes (2-0) L: Teddy Higuera (4-5) | Seventh | 14½ out |
| Saturday, May 30 |
| » Lost to Brewers (23-21), 6-5 | Cleveland Stadium (9-13) | 16-33 | |
| » W: Mark Clear (4-1) L: Mark Huismann (0-3) S: Dan Plesac (11) | Seventh | 14½ out |
| Sunday, May 31 |
| » Lost to Brewers (24-21), 7-1 | Cleveland Stadium (9-14) | 16-34 | Lost 2 |
| » W: Juan Nieves (4-2) L: Greg Swindell (3-5) | Seventh | 15½ out |
| Monday, June 1 |
| » Defeated Tigers (24-24), 9-6 | Cleveland Stadium (10-14) | 17-34 | |
| » W: Phil Niekro (3-5) L: Dan Petry (2-4) S: Scott Bailes (3) | Seventh | 14½ out |
| Wednesday, June 3 |
| » Lost to Tigers (25-24), 15-3 | Cleveland Stadium (10-15) | 17-35 | |
| » W: Jack Morris (7-2) L: Ken Schrom (4-5) | Seventh | 16 out |
| Friday, June 5 |
| » Defeated Athletics (26-26), 4-3 | Oakland-Alameda County Stadium (1-0) | 18-35 | |
| » W: Tom Candiotti (2-6) L: Joaquin Andujar (1-1) S: Scott Bailes (4) | Seventh | 15½ out |
| Saturday, June 6 |
| » Lost to Athletics (27-26), 6-4 | Oakland-Alameda County Stadium (1-1) | 18-36 | |
| » W: Dennis Eckersley (4-4) L: Greg Swindell (3-6) | Seventh | 15½ out |
| Sunday, June 7 |
| » Defeated Athletics (27-27), 12-2 | Oakland-Alameda County Stadium (2-1) | 19-36 | |
| » W: Steve Carlton (4-4) L: Dave Stewart (6-6) | Seventh | 15½ out |
| Monday, June 8 |
| » Defeated Angels (25-32), 2-0 | Anaheim Stadium (1-0) | 20-36 | Won 2 |
| » W: Phil Niekro (4-5) L: Don Sutton (2-7) S: Scott Bailes (5) | Seventh | 15 out |
| Tuesday, June 9 |
| » Lost to Angels (26-32), 6-5 | Anaheim Stadium (1-1) | 20-37 | |
| » W: Jack Lazorko (2-2) L: Rich Yett (1-4) S: DeWayne Buice (4) | Seventh | 16 out |
| Wednesday, June 10 |
| » Lost to Angels (27-32), 10-7 | Anaheim Stadium (1-2) | 20-38 | Lost 2 |
| » W: Greg Minton (2-0) L: Scott Bailes (2-1) | Seventh | 17 out |
| Friday, June 12 |
| » Defeated Mariners (29-31), 10-6 | Kingdome (1-0) | 21-38 | |
| » W: Mark Huismann (1-3) L: Mike Trujillo (2-4) | Seventh | 17½ out |
| Saturday, June 13 |
| » Defeated Mariners (29-32), 6-1 | Kingdome (2-0) | 22-38 | Won 2 |
| » W: Phil Niekro (5-5) L: Mark Langston (7-6) | Seventh | 17½ out |
| Sunday, June 14 |
| » Lost to Mariners (30-32), 4-3 | Kingdome (2-1) | 22-39 | |
| » W: Ed Nunez (2-1) L: Rich Yett (1-5) | Sixth | 17½ out |
| Tuesday, June 16 |
| » Defeated Red Sox (28-35), 8-7 | Cleveland Stadium (11-15) | 23-39 | |
| » W: Mark Huismann (2-3) L: Al Nipper (5-6) S: Mike Armstrong (1) | Seventh | 17 out |
| Wednesday, June 17 |
| » Lost to Red Sox (29-35), 4-0 | Cleveland Stadium (11-16) | 23-40 | |
| » W: Roger Clemens (5-6) L: Tom Candiotti (2-7) | Seventh | 17 out |
| Former Indian Dick Howser dies in Kansas City, MO at the age of 52. |
| Thursday, June 18 |
| » Defeated Red Sox (29-36), 7-5 | Cleveland Stadium (12-16) | 24-40 | |
| » W: Mike Armstrong (1-0) L: Bob Stanley (3-8) S: Mark Huismann (1) | Sixth | 16 out |
| Friday, June 19 |
| » Lost to Mariners (34-32), 7-4 | Cleveland Stadium (12-17) | 24-41 | |
| » W: Mark Langston (8-6) L: Phil Niekro (5-6) | Seventh | 17 out |
| Saturday, June 20 |
| » Defeated Mariners (34-33), 9-2 | Cleveland Stadium (13-17) | 25-41 | |
| » W: Steve Carlton (5-4) L: Mike Morgan (5-8) | Seventh | 16 out |
| Sunday, June 21 |
| » Lost to Mariners (35-33), 5-0 | Cleveland Stadium (13-18) | 25-42 | |
| » W: Lee Guetterman (5-0) L: Ken Schrom (4-6) | Seventh | 17 out |
| Tuesday, June 23 |
| » Lost to Twins (40-29), 9-4 | Hubert H. Humphrey Metrodome (0-1) | 25-43 | Lost 2 |
| » W: Mike Smithson (4-3) L: Tom Candiotti (2-8) S: George Frazier (2) | Seventh | 17½ out |
| Wednesday, June 24 |
| » Lost to Twins (41-29), 14-8 | Hubert H. Humphrey Metrodome (0-2) | 25-44 | Lost 3 |
| » W: Les Straker (3-4) L: Greg Swindell (3-7) | Seventh | 18½ out |
| Thursday, June 25 |
| » Lost to Twins (42-29), 4-3 | Hubert H. Humphrey Metrodome (0-3) | 25-45 | Lost 4 |
| » W: Bert Blyleven (6-6) L: Phil Niekro (5-7) S: Jeff Reardon (15) | Seventh | 19 out |
| Friday, June 26 |
| » Lost to Athletics (38-33), 5-0 | Cleveland Stadium (13-19) | 25-46 | Lost 5 |
| » W: Dave Stewart (9-7) L: Steve Carlton (5-5) S: Gene Nelson (1) | Seventh | 19 out |
| Saturday, June 27 |
| » Lost to Athletics (39-33), 13-3 | Cleveland Stadium (13-20) | 25-47 | Lost 6 |
| » W: Joaquin Andujar (2-1) L: Ken Schrom (4-7) | Seventh | 20 out |
| Sunday, June 28 |
| » Lost to Athletics (40-33), 10-0 | Cleveland Stadium (13-21) | 25-48 | Lost 7 |
| » W: Steve Ontiveros (5-1) L: Tom Candiotti (2-9) | Seventh | 20 out |
| Monday, June 29 |
| » Lost to Angels (38-38), 11-4 | Cleveland Stadium (13-22) | 25-49 | Lost 8 |
| » W: Don Sutton (5-8) L: Greg Swindell (3-8) S: Greg Minton (5) | Seventh | 21 out |
| Tuesday, June 30 |
| » Defeated Angels (38-39), 2-1 | Cleveland Stadium (14-22) | 26-49 | |
| » W: Phil Niekro (6-7) L: Jack Lazorko (2-4) S: Scott Bailes (6) | Seventh | 21 out |
| Wednesday, July 1 |
| » Lost to Angels (39-39), 10-5 | Cleveland Stadium (14-23) | 26-50 | |
| » W: Jerry Reuss (3-5) L: Steve Carlton (5-6) S: DeWayne Buice (7) | Seventh | 22 out |
| Thursday, July 2 |
| » Defeated White Sox (28-47), 2-1 | Cleveland Stadium (15-23) | 27-50 | |
| » W: Doug Jones (1-1) L: Bob James (2-4) | Seventh | 21½ out |
| Friday, July 3 |
| » Lost to White Sox (29-47), 14-9 | Cleveland Stadium (15-24) | 27-51 | |
| » W: Jim Winn (4-4) L: Sammy Stewart (0-1) | Seventh | 22 out |
| Saturday, July 4 |
| » Lost to White Sox (30-47), 3-2 | Cleveland Stadium (15-25) | 27-52 | Lost 2 |
| » W: Richard Dotson (6-5) L: Scott Bailes (2-2) S: Bob James (9) | Seventh | 23 out |
| Sunday, July 5 |
| » Lost to White Sox (31-47), 17-0 | Cleveland Stadium (15-26) | 27-53 | Lost 3 |
| » W: Scott Nielsen (2-2) L: Phil Niekro (6-8) | Seventh | 23 out |
| Monday, July 6 |
| » Defeated Royals (45-36), 9-7 | Cleveland Stadium (16-26) | 28-53 | |
| » W: Sammy Stewart (1-1) L: Bret Saberhagen (14-3) S: Mark Huismann (2) | Seventh | 22 out |
| Tuesday, July 7 |
| » Defeated Royals (45-37), 6-4 | Cleveland Stadium (17-26) | 29-53 | Won 2 |
| » W: Doug Jones (2-1) L: Dan Quisenberry (4-1) | Seventh | 22 out |
| Wednesday, July 8 |
| » Defeated Royals (45-38), 9-8 | Cleveland Stadium (18-26) | 30-53 | Won 3 |
| » W: Sammy Stewart (2-1) L: Jerry Gleaton (1-3) | Seventh | 22 out |
| Thursday, July 9 |
| » Defeated Rangers (38-45), 10-4 | Arlington Stadium (1-2) | 31-53 | Won 4 |
| » W: Doug Jones (3-1) L: Jose Guzman (6-8) | Seventh | 21 out |
| Friday, July 10 |
| » Lost to Rangers (39-45), 10-4 | Arlington Stadium (1-3) | 31-54 | |
| » W: Greg Harris (3-8) L: Phil Niekro (6-9) | Seventh | 22 out |
| Saturday, July 11 |
| » Lost to Rangers (40-45), 6-2 | Arlington Stadium (1-4) | 31-55 | Lost 2 |
| » W: Charlie Hough (10-4) L: Steve Carlton (5-7) S: Jeff Russell (3) | Seventh | 22 out |
| Sunday, July 12 |
| » Lost to Rangers (41-45), 7-6 | Arlington Stadium (1-5) | 31-56 | Lost 3 |
| » W: Jose Guzman (7-8) L: Doug Jones (3-2) S: Dale Mohorcic (12) | Seventh | 23 out |
| Thursday, July 16 |
| » Defeated White Sox (34-52), 4-3 | Comiskey Park I (2-1) | 32-56 | |
| » Manager: Doc Edwards |
| » W: Scott Bailes (3-2) L: Richard Dotson (7-6) S: Sammy Stewart (1) | Seventh | 23 out |
| Friday, July 17 |
| » Lost to White Sox (35-52), 4-3 | Comiskey Park I (2-2) | 32-57 | |
| » W: Bob James (3-4) L: Doug Jones (3-3) | Seventh | 24 out |
| Saturday, July 18 |
| » Lost to White Sox (36-52), 6-3 | Comiskey Park I (2-3) | 32-58 | Lost 2 |
| » W: Bobby Thigpen (3-2) L: Tom Candiotti (2-10) S: Jim Winn (3) | Seventh | 24 out |
| » Major-league debuts: Bill Lindsey (White Sox) |
| Sunday, July 19 |
| » Lost to White Sox (37-52), 9-7 | Comiskey Park I (2-4) | 32-59 | Lost 3 |
| » W: Scott Nielsen (3-3) L: Steve Carlton (5-8) S: Jim Winn (4) | Seventh | 24 out |
| Monday, July 20 |
| » Defeated Royals (46-46), 9-5 | Royals Stadium (2-2) | 33-59 | |
| » W: Phil Niekro (7-9) L: Bret Saberhagen (15-4) S: Doug Jones (1) | Seventh | 24 out |
| Tuesday, July 21 |
| » Lost to Royals (47-46), 3-2 | Royals Stadium (2-3) | 33-60 | |
| » W: Charlie Leibrandt (9-8) L: Scott Bailes (3-3) | Seventh | 24 out |
| Wednesday, July 22 |
| » Lost to Royals (48-46), 5-1 | Royals Stadium (2-4) | 33-61 | Lost 2 |
| » W: Mark Gubicza (8-9) L: Darrel Akerfelds (0-1) | Seventh | 24 out |
| Former Indian Don McMahon dies in Los Angeles, CA at the age of 58. |
| Thursday, July 23 |
| » Defeated Rangers (45-49), 4-2 | Cleveland Stadium (19-26) | 34-61 | |
| » W: Tom Candiotti (3-10) L: Jose Guzman (8-9) | Seventh | 23½ out |
| Friday, July 24 |
| » Lost to Rangers (46-49), 6-3 | Cleveland Stadium (19-27) | 34-62 | |
| » W: Jeff Russell (4-1) L: Steve Carlton (5-9) S: Dale Mohorcic (14) | Seventh | 23½ out |
| Saturday, July 25 |
| » Lost to Rangers (47-49), 7-3 | Cleveland Stadium (19-28) | 34-63 | Lost 2 |
| » W: Charlie Hough (11-6) L: Phil Niekro (7-10) S: Dale Mohorcic (15) | Seventh | 23½ out |
| Sunday, July 26 |
| » Lost to Rangers (48-49), 11-3 | Cleveland Stadium (19-29) | 34-64 | Lost 3 |
| » W: Paul Kilgus (1-1) L: Scott Bailes (3-4) | Seventh | 24½ out |
| Tuesday, July 28 |
| » Defeated Orioles (45-55), 4-3 | Cleveland Stadium (20-29) | 35-64 | |
| » W: Sammy Stewart (3-1) L: Tom Niedenfuer (3-3) | Seventh | 24½ out |
| Wednesday, July 29 |
| » Lost to Orioles (46-55), 7-4 | Cleveland Stadium (20-30) | 35-65 | |
| » W: Eric Bell (9-7) L: Tom Candiotti (3-11) | Seventh | 25½ out |
| Thursday, July 30 |
| » Defeated Orioles (46-56), 6-4 | Cleveland Stadium (21-30) | 36-65 | |
| » W: Sammy Stewart (4-1) L: Mark Williamson (5-7) | Seventh | 25½ out |
| Friday, July 31 |
| » Lost to Blue Jays (60-42), 8-3 | Exhibition Stadium (1-3) | 36-66 | |
| » W: Jimmy Key (12-6) L: Reggie Ritter (0-1) | Seventh | 26½ out |
| Saturday, August 1 |
| » Defeated Blue Jays (60-43), 3-0 | Exhibition Stadium (2-3) | 37-66 | |
| » W: Scott Bailes (4-4) L: Jim Clancy (10-7) S: Sammy Stewart (2) | Seventh | 25½ out |
| Sunday, August 2 |
| » Lost to Blue Jays (61-43), 11-5 | Exhibition Stadium (2-4) | 37-67 | |
| » W: Dave Stieb (10-5) L: Darrel Akerfelds (0-2) S: Gary Lavelle (1) | Seventh | 26½ out |
| Monday, August 3 |
| » Defeated Yankees (64-42), 2-0 | Cleveland Stadium (22-30) | 38-67 | |
| » W: Tom Candiotti (4-11) L: Steve Trout (6-6) | Seventh | 25½ out |
| Tuesday, August 4 |
| » Defeated Yankees (64-43), 15-3 | Cleveland Stadium (23-30) | 39-67 | Won 2 |
| » W: Ken Schrom (5-7) L: Tommy John (10-4) | Seventh | 24½ out |
| Wednesday, August 5 |
| » Lost to Yankees (65-43), 5-2 | Cleveland Stadium (23-31) | 39-68 | |
| » W: Brad Arnsberg (1-0) L: Phil Niekro (7-11) S: Dave Righetti (21) | Seventh | 25½ out |
| Thursday, August 6 |
| » Defeated Blue Jays (64-44), 14-5 | Cleveland Stadium (24-31) | 40-68 | |
| » W: Scott Bailes (5-4) L: Jim Clancy (10-8) | Seventh | 24½ out |
| Friday, August 7 |
| » Lost to Blue Jays (65-44), 15-1 | Cleveland Stadium (24-32) | 40-69 | |
| » W: Dave Stieb (11-5) L: Darrel Akerfelds (0-3) | Seventh | 25 out |
| Saturday, August 8 |
| » Defeated Blue Jays (65-45), 3-1 | Cleveland Stadium (25-32) | 41-69 | |
| » W: Tom Candiotti (5-11) L: Jose Nunez (1-1) | Seventh | 24½ out |
| Sunday, August 9 |
| » Lost to Blue Jays (66-45), 5-1 | Cleveland Stadium (25-33) | 41-70 | |
| » W: John Cerutti (8-2) L: Ken Schrom (5-8) | Seventh | 25 out |
| Monday, August 10 |
| » Lost to Orioles (51-61), 4-3 | Memorial Stadium (2-3) | 41-71 | Lost 2 |
| » W: Mark Williamson (6-8) L: Don Gordon (0-1) S: Tom Niedenfuer (8) | Seventh | 25 out |
| Tuesday, August 11 |
| » Defeated Orioles (51-62), 6-3 | Memorial Stadium (3-3) | 42-71 | |
| » W: Scott Bailes (6-4) L: Dave J. Schmidt (10-3) S: Doug Jones (2) | Seventh | 25 out |
| Wednesday, August 12 |
| » Defeated Orioles (51-63), 8-6 | Memorial Stadium (4-3) | 43-71 | Won 2 |
| » W: Darrel Akerfelds (1-3) L: Mike Griffin (2-5) S: Doug Jones (3) | Seventh | 25 out |
| Friday, August 14 |
| » Defeated Yankees (66-50), 6-5 | Yankee Stadium (1-3) | 44-71 | Won 3 |
| » W: Tom Candiotti (6-11) L: Brad Arnsberg (1-2) S: Doug Jones (4) | Seventh | 24½ out |
| Saturday, August 15 |
| » Lost to Yankees (67-50), 11-2 | Yankee Stadium (1-4) | 44-72 | |
| » W: Dennis Rasmussen (9-6) L: Ken Schrom (5-9) S: Tim Stoddard (5) | Seventh | 24½ out |
| Sunday, August 16 |
| » Defeated Yankees (67-51), 1-0 | Yankee Stadium (2-4) | 45-72 | |
| » W: Rich Yett (2-5) L: Ron Guidry (3-7) S: Doug Jones (5) | Seventh | 24½ out |
| Monday, August 17 |
| » Lost to Brewers (62-56), 5-3 | Cleveland Stadium (25-34) | 45-73 | |
| » W: Mark Knudson (3-3) L: Scott Bailes (6-5) | Seventh | 25 out |
| Tuesday, August 18 |
| » Defeated Brewers (62-57), 9-8 | Cleveland Stadium (26-34) | 46-73 | |
| » W: John Farrell (1-0) L: Ray Burris (1-2) | Seventh | 25 out |
| » Major-league debuts: John Farrell (Indians) |
| Wednesday, August 19 |
| » Lost to Brewers (63-57), 13-2 | Cleveland Stadium (26-35) | 46-74 | |
| » W: Juan Nieves (10-6) L: Tom Candiotti (6-12) | Seventh | 25½ out |
| Thursday, August 20 |
| » Lost to Brewers (64-57), 14-2 | Cleveland Stadium (26-36) | 46-75 | Lost 2 |
| » W: Teddy Higuera (12-9) L: Ken Schrom (5-10) | Seventh | 26½ out |
| Friday, August 21 |
| » Defeated Tigers (71-48), 12-4 | Cleveland Stadium (27-36) | 47-75 | |
| » W: Jamie Easterly (1-0) L: Dan Petry (7-6) S: Don Gordon (1) | Seventh | 24½ out |
| » Defeated Tigers (71-49), 8-3 | Cleveland Stadium (28-36) | 48-75 | Won 2 |
| » W: John Farrell (2-0) L: Frank Tanana (13-8) | Seventh | 24½ out |
| Saturday, August 22 |
| » Lost to Tigers (72-49), 8-6 | Cleveland Stadium (28-37) | 48-76 | |
| » W: Mike Henneman (9-1) L: Scott Bailes (6-6) S: Eric King (8) | Seventh | 25½ out |
| Sunday, August 23 |
| » Lost to Tigers (73-49), 4-3 | Cleveland Stadium (28-38) | 48-77 | Lost 2 |
| » W: Jack Morris (15-6) L: Tom Candiotti (6-13) | Seventh | 26½ out |
| Tuesday, August 25 |
| » Lost to Brewers (67-58), 10-9 | County Stadium (2-2) | 48-78 | Lost 3 |
| » W: Juan Nieves (11-6) L: Ken Schrom (5-11) S: Chuck Crim (6) | Seventh | 27 out |
| Wednesday, August 26 |
| » Lost to Brewers (68-58), 1-0 | County Stadium (2-3) | 48-79 | Lost 4 |
| » W: Teddy Higuera (13-9) L: Doug Jones (3-4) | Seventh | 28 out |
| Thursday, August 27 |
| » Lost to Brewers (69-58), 4-3 | County Stadium (2-4) | 48-80 | Lost 5 |
| » W: Mark Knudson (4-4) L: Darrel Akerfelds (1-4) S: Chuck Crim (7) | Seventh | 28½ out |
| Saturday, August 29 |
| » Defeated Red Sox (61-66), 7-2 | Cleveland Stadium (29-38) | 49-80 | |
| » W: Tom Candiotti (7-13) L: Bob Stanley (4-13) | Seventh | 27½ out |
| » Defeated Red Sox (61-67), 2-1 | Cleveland Stadium (30-38) | 50-80 | Won 2 |
| » W: Rich Yett (3-5) L: Bruce Hurst (14-9) | Seventh | 27½ out |
| Sunday, August 30 |
| » Lost to Red Sox (62-67), 7-3 | Cleveland Stadium (30-39) | 50-81 | |
| » W: Roger Clemens (14-8) L: Scott Bailes (6-7) S: Wes Gardner (8) | Seventh | 28½ out |
| Monday, August 31 |
| » Defeated Tigers (77-52), 7-2 | Tiger Stadium (1-3) | 51-81 | |
| » W: John Farrell (3-0) L: Frank Tanana (13-9) | Seventh | 27½ out |
| Tuesday, September 1 |
| » Lost to Tigers (78-52), 6-5 | Tiger Stadium (1-4) | 51-82 | |
| » W: Guillermo Hernandez (3-2) L: Don Gordon (0-2) | Seventh | 28½ out |
| » Major-league debuts: Scott Lusader (Tigers) |
| Wednesday, September 2 |
| » Lost to Tigers (79-52), 2-1 | Tiger Stadium (1-5) | 51-83 | Lost 2 |
| » W: Jack Morris (16-7) L: Tom Candiotti (7-14) | Seventh | 29½ out |
| Former Indian Cam Carreon dies in Tucson, AZ at the age of 51. |
| Thursday, September 3 |
| » Lost to Tigers (80-52), 3-1 | Tiger Stadium (1-6) | 51-84 | Lost 3 |
| » W: Walt Terrell (12-10) L: Rich Yett (3-6) | Seventh | 30½ out |
| Friday, September 4 |
| » Lost to Red Sox (64-69), 5-2 | Fenway Park (0-5) | 51-85 | Lost 4 |
| » W: Roger Clemens (15-8) L: Scott Bailes (6-8) S: Wes Gardner (9) | Seventh | 31½ out |
| Saturday, September 5 |
| » Defeated Red Sox (64-70), 15-2 | Fenway Park (1-5) | 52-85 | |
| » W: John Farrell (4-0) L: Bob Stanley (4-14) | Seventh | 30½ out |
| Sunday, September 6 |
| » Defeated Red Sox (64-71), 3-1 | Fenway Park (2-5) | 53-85 | Won 2 |
| » W: Darrel Akerfelds (2-4) L: Jeff Sellers (6-7) S: Doug Jones (6) | Seventh | 30 out |
| Monday, September 7 |
| » Lost to Mariners (64-73), 6-4 | Cleveland Stadium (30-40) | 53-86 | |
| » W: Mark Langston (17-10) L: Tom Candiotti (7-15) S: Jerry Reed (5) | Seventh | 31 out |
| Tuesday, September 8 |
| » Lost to Mariners (65-73), 7-0 | Cleveland Stadium (30-41) | 53-87 | Lost 2 |
| » W: Mike Morgan (11-15) L: Rich Yett (3-7) | Seventh | 31 out |
| » Major-league debuts: Brian Dorsett (Indians) |
| Wednesday, September 9 |
| » Lost to Mariners (66-73), 9-4 | Cleveland Stadium (30-42) | 53-88 | Lost 3 |
| » W: Mike Moore (7-17) L: Jamie Easterly (1-1) | Seventh | 32½ out |
| Thursday, September 10 |
| » Major-league debuts: Jose Mesa (Orioles) |
| Friday, September 11 |
| » Lost to Twins (76-66), 13-10 | Cleveland Stadium (30-43) | 53-89 | Lost 4 |
| » W: Jeff Reardon (7-7) L: Don Gordon (0-3) S: Juan Berenguer (4) | Sixth | 32 out |
| Saturday, September 12 |
| » Defeated Twins (76-67), 5-4 | Cleveland Stadium (31-43) | 54-89 | |
| » W: Doug Jones (4-4) L: Juan Berenguer (6-1) | Seventh | 32 out |
| Sunday, September 13 |
| » Lost to Twins (77-67), 7-3 | Cleveland Stadium (31-44) | 54-90 | |
| » W: Jeff Reardon (8-7) L: Tom Candiotti (7-16) | Sixth | |