| Monday, April 6 |
| » Defeated Indians (0-1), 7-3 | Exhibition Stadium (1-0) | 1-0 | |
| » W: Jimmy Key (1-0) L: Tom Candiotti (0-1) | First | -- |
| » Major-league debuts: Mike Sharperson (Blue Jays) |
| Wednesday, April 8 |
| » Defeated Indians (0-2), 5-1 | Exhibition Stadium (2-0) | 2-0 | Won 2 |
| » W: Jim Clancy (1-0) L: Greg Swindell (0-1) | First | -- |
| Thursday, April 9 |
| » Lost to Indians (1-2), 14-3 | Exhibition Stadium (2-1) | 2-1 | |
| » W: Phil Niekro (1-0) L: Joe Johnson (0-1) S: Steve Carlton (1) | Second | 1 out |
| » Major-league debuts: Jose Nunez (Blue Jays) |
| Friday, April 10 |
| » Lost to Red Sox (1-3), 3-0 | Fenway Park (0-1) | 2-2 | Lost 2 |
| » W: Bruce Hurst (1-0) L: Dave Stieb (0-1) | Third | 2 out |
| Saturday, April 11 |
| » Defeated Red Sox (1-4), 11-1 | Fenway Park (1-1) | 3-2 | |
| » W: Jimmy Key (2-0) L: Roger Clemens (0-1) | Third | 2 out |
| Sunday, April 12 |
| » Lost to Red Sox (2-4), 8-3 | Fenway Park (1-2) | 3-3 | |
| » W: Bob Stanley (1-1) L: Jim Clancy (1-1) | Fourth | 3 out |
| Tuesday, April 14 |
| » Defeated White Sox (2-5), 4-3 | Exhibition Stadium (3-1) | 4-3 | |
| » W: Mark Eichhorn (1-0) L: Joel McKeon (0-1) | Third | 3½ out |
| Wednesday, April 15 |
| » Lost to White Sox (3-5), 5-0 | Exhibition Stadium (3-2) | 4-4 | |
| » W: Jose DeLeon (2-0) L: Dave Stieb (0-2) | Fourth | 4½ out |
| Thursday, April 16 |
| » Defeated Red Sox (4-5), 4-2 | Exhibition Stadium (4-2) | 5-4 | |
| » W: Jimmy Key (3-0) L: Roger Clemens (0-2) S: Tom Henke (1) | Third | 4 out |
| Friday, April 17 |
| » Defeated Red Sox (4-6), 10-5 | Exhibition Stadium (5-2) | 6-4 | Won 2 |
| » W: John Cerutti (1-0) L: Bob Stanley (1-2) S: Mark Eichhorn (1) | Third | 4 out |
| Saturday, April 18 |
| » Lost to Red Sox (5-6), 6-4 | Exhibition Stadium (5-3) | 6-5 | |
| » W: Jeff Sellers (1-0) L: Jim Clancy (1-2) S: Calvin Schiraldi (2) | Fifth | 5 out |
| Sunday, April 19 |
| » Lost to Red Sox (6-6), 4-1 | Exhibition Stadium (5-4) | 6-6 | Lost 2 |
| » W: Al Nipper (2-0) L: Joe Johnson (0-2) S: Wes Gardner (2) | Fifth | 6 out |
| Monday, April 20 |
| » Defeated Indians (3-11), 8-7 | Cleveland Stadium (1-0) | 7-6 | |
| » W: Jeff Musselman (1-0) L: Doug Jones (0-1) | Third | 6 out |
| Tuesday, April 21 |
| » Lost to Indians (4-11), 5-0 | Cleveland Stadium (1-1) | 7-7 | |
| » W: Tom Candiotti (1-3) L: Jimmy Key (3-1) | Third | 6 out |
| Wednesday, April 22 |
| » Defeated Indians (4-12), 6-3 | Cleveland Stadium (2-1) | 8-7 | |
| » W: Mark Eichhorn (2-0) L: Steve Carlton (1-2) S: Tom Henke (2) | Third | 5½ out |
| Friday, April 24 |
| » Defeated White Sox (5-9), 4-2 | Comiskey Park I (1-0) | 9-7 | Won 2 |
| » W: Mark Eichhorn (3-0) L: Bob James (0-1) S: Tom Henke (3) | Third | 5½ out |
| Saturday, April 25 |
| » Lost to White Sox (6-9), 5-4 | Comiskey Park I (1-1) | 9-8 | |
| » W: Bob James (1-1) L: Mark Eichhorn (3-1) | Third | 6½ out |
| Sunday, April 26 |
| » Defeated White Sox (6-10), 5-2 | Comiskey Park I (2-1) | 10-8 | |
| » W: Jimmy Key (4-1) L: Jose DeLeon (2-2) S: Tom Henke (4) | Third | 6½ out |
| Tuesday, April 28 |
| » Defeated Twins (12-8), 5-1 | Exhibition Stadium (6-4) | 11-8 | Won 2 |
| » W: Jim Clancy (2-2) L: Frank Viola (1-3) | Third | 6 out |
| Wednesday, April 29 |
| » Defeated Twins (12-9), 8-1 | Exhibition Stadium (7-4) | 12-8 | Won 3 |
| » W: Joe Johnson (1-2) L: Mike Smithson (3-1) | Third | 6 out |
| Thursday, April 30 |
| » Major-league debuts: Ellis Burks (Red Sox) |
| Friday, May 1 |
| » Defeated Rangers (8-12), 3-2 | Exhibition Stadium (8-4) | 13-8 | Won 4 |
| » W: Jeff Musselman (2-0) L: Mitch Williams (2-2) | Third | 5½ out |
| » Major-league debuts: Rob Ducey (Blue Jays) |
| Saturday, May 2 |
| » Defeated Rangers (8-13), 9-8 | Exhibition Stadium (9-4) | 14-8 | Won 5 |
| » W: Mark Eichhorn (4-1) L: Greg Harris (1-3) | Third | 5½ out |
| Sunday, May 3 |
| » Defeated Rangers (8-14), 3-1 | Exhibition Stadium (10-4) | 15-8 | Won 6 |
| » W: Jim Clancy (3-2) L: Ed Correa (1-2) S: Tom Henke (5) | Second | 4½ out |
| Tuesday, May 5 |
| » Lost to Royals (12-11), 6-4 | Royals Stadium (0-1) | 15-9 | |
| » W: Charlie Leibrandt (4-1) L: Joe Johnson (1-3) S: Jerry Gleaton (1) | Second | 4½ out |
| Wednesday, May 6 |
| » Lost to Royals (13-11), 6-3 | Royals Stadium (0-2) | 15-10 | Lost 2 |
| » W: Buddy Black (1-0) L: Jimmy Key (4-2) S: Jerry Gleaton (2) | Third | 4½ out |
| Friday, May 8 |
| » Defeated Rangers (10-15), 7-4 | Arlington Stadium (1-0) | 16-10 | |
| » W: Jim Clancy (4-2) L: Jose Guzman (1-2) S: Mark Eichhorn (2) | Third | 3½ out |
| Saturday, May 9 |
| » Defeated Rangers (10-16), 15-4 | Arlington Stadium (2-0) | 17-10 | Won 2 |
| » W: Dave Stieb (1-2) L: Ed Correa (1-3) | Second | 2½ out |
| Sunday, May 10 |
| » Lost to Rangers (11-16), 9-8 | Arlington Stadium (2-1) | 17-11 | |
| » W: Bobby Witt (1-1) L: Mark Eichhorn (4-2) S: Dale Mohorcic (3) | Third | 2½ out |
| Monday, May 11 |
| » Defeated Royals (15-13), 4-0 | Exhibition Stadium (11-4) | 18-11 | |
| » W: Jimmy Key (5-2) L: Charlie Leibrandt (4-2) | Third | 2 out |
| Tuesday, May 12 |
| » Lost to Royals (16-13), 3-1 | Exhibition Stadium (11-5) | 18-12 | |
| » W: Buddy Black (2-0) L: John Cerutti (1-1) S: Dan Quisenberry (3) | Third | 2 out |
| Wednesday, May 13 |
| » Defeated Twins (17-16), 7-0 | Hubert H. Humphrey Metrodome (1-0) | 19-12 | |
| » W: Jim Clancy (5-2) L: Mark Portugal (1-2) | Third | 1 out |
| Thursday, May 14 |
| » Defeated Twins (17-17), 16-4 | Hubert H. Humphrey Metrodome (2-0) | 20-12 | Won 2 |
| » W: Dave Stieb (2-2) L: Les Straker (2-1) | Third | 1 out |
| Friday, May 15 |
| » Defeated Athletics (16-18), 3-2 | Oakland-Alameda County Stadium (1-0) | 21-12 | Won 3 |
| » W: Joe Johnson (2-3) L: Eric Plunk (1-2) S: Tom Henke (6) | Second | 1 out |
| Saturday, May 16 |
| » Lost to Athletics (17-18), 10-3 | Oakland-Alameda County Stadium (1-1) | 21-13 | |
| » W: Moose Haas (1-0) L: Jimmy Key (5-3) | Second | 1 out |
| Sunday, May 17 |
| » Lost to Athletics (18-18), 3-0 | Oakland-Alameda County Stadium (1-2) | 21-14 | Lost 2 |
| » W: Dave Stewart (5-3) L: John Cerutti (1-2) | Second | 2 out |
| Monday, May 18 |
| » Defeated Angels (19-19), 12-0 | Anaheim Stadium (1-0) | 22-14 | |
| » W: Jim Clancy (6-2) L: Mike Cook (1-2) | Second | 2 out |
| Tuesday, May 19 |
| » Lost to Angels (20-19), 2-1 | Anaheim Stadium (1-1) | 22-15 | |
| » W: DeWayne Buice (2-2) L: Jeff Musselman (2-1) S: Donnie Moore (5) | Second | 2 out |
| Wednesday, May 20 |
| » Lost to Angels (21-19), 5-4 | Anaheim Stadium (1-2) | 22-16 | Lost 2 |
| » W: Gary Lucas (1-1) L: Tom Henke (0-1) | Third | 2 out |
| Friday, May 22 |
| » Defeated Mariners (21-20), 7-5 | Kingdome (1-0) | 23-16 | |
| » W: Mark Eichhorn (5-2) L: Scott Bankhead (5-3) S: Tom Henke (7) | Third | 2 out |
| Saturday, May 23 |
| » Defeated Mariners (21-21), 6-2 | Kingdome (2-0) | 24-16 | Won 2 |
| » W: Jim Clancy (7-2) L: Mike Moore (2-5) | Second | 2 out |
| Sunday, May 24 |
| » Lost to Mariners (22-21), 5-2 | Kingdome (2-1) | 24-17 | |
| » W: Mark Langston (5-4) L: Dave Stieb (2-3) | Second | 3 out |
| Monday, May 25 |
| » Defeated Mariners (22-22), 6-5 | Kingdome (3-1) | 25-17 | |
| » W: Jimmy Key (6-3) L: Mike Morgan (4-5) S: Jeff Musselman (1) | Second | 3 out |
| Wednesday, May 27 |
| » Lost to Athletics (21-23), 4-1 | Exhibition Stadium (11-6) | 25-18 | |
| » W: Moose Haas (2-1) L: Joe Johnson (2-4) S: Steve Ontiveros (1) | Second | 3 out |
| Thursday, May 28 |
| » Lost to Athletics (22-23), 4-3 | Exhibition Stadium (11-7) | 25-19 | Lost 2 |
| » W: Dave Stewart (6-4) L: Jim Clancy (7-3) S: Dave Leiper (1) | Second | 4 out |
| Friday, May 29 |
| » Defeated Angels (21-26), 3-1 | Exhibition Stadium (12-7) | 26-19 | |
| » W: Dave Stieb (3-3) L: Don Sutton (2-5) S: Tom Henke (8) | Second | 3 out |
| Saturday, May 30 |
| » Defeated Angels (21-27), 4-3 | Exhibition Stadium (13-7) | 27-19 | Won 2 |
| » W: Mark Eichhorn (6-2) L: Jack Lazorko (0-2) | Second | 2 out |
| Sunday, May 31 |
| » Defeated Angels (21-28), 7-2 | Exhibition Stadium (14-7) | 28-19 | Won 3 |
| » W: John Cerutti (2-2) L: John Candelaria (4-2) | Second | 2 out |
| Monday, June 1 |
| » Lost to Mariners (27-23), 2-0 | Exhibition Stadium (14-8) | 28-20 | |
| » W: Scott Bankhead (6-3) L: Joe Johnson (2-5) S: Bill Wilkinson (2) | Second | 2 out |
| Tuesday, June 2 |
| » Defeated Mariners (27-24), 4-3 | Exhibition Stadium (15-8) | 29-20 | |
| » W: Jeff Musselman (3-1) L: Mike Moore (2-7) S: Tom Henke (9) | Second | 2 out |
| Wednesday, June 3 |
| » Defeated Mariners (27-25), 7-2 | Exhibition Stadium (16-8) | 30-20 | Won 2 |
| » W: Dave Stieb (4-3) L: Mark Langston (6-5) S: Mark Eichhorn (3) | Second | 2 out |
| Friday, June 5 |
| » Defeated Orioles (27-26), 6-2 | Exhibition Stadium (17-8) | 31-20 | Won 3 |
| » W: Jimmy Key (7-3) L: Eric Bell (5-3) | Second | 1½ out |
| Saturday, June 6 |
| » Defeated Orioles (27-27), 8-5 | Exhibition Stadium (18-8) | 32-20 | Won 4 |
| » W: Jeff Musselman (4-1) L: Ken Dixon (3-5) | Second | 1½ out |
| Sunday, June 7 |
| » Defeated Orioles (27-28), 3-2 | Exhibition Stadium (19-8) | 33-20 | Won 5 |
| » W: Mark Eichhorn (7-2) L: Mike Boddicker (5-2) | Second | 1½ out |
| Monday, June 8 |
| » Defeated Yankees (35-22), 11-0 | Yankee Stadium (1-0) | 34-20 | Won 6 |
| » W: Dave Stieb (5-3) L: Rick Rhoden (6-4) | First | -- |
| Tuesday, June 9 |
| » Defeated Yankees (35-23), 7-2 | Yankee Stadium (2-0) | 35-20 | Won 7 |
| » W: John Cerutti (3-2) L: Ron Guidry (0-2) | First | -- |
| Wednesday, June 10 |
| » Defeated Yankees (35-24), 4-1 | Yankee Stadium (3-0) | 36-20 | Won 8 |
| » W: Jimmy Key (8-3) L: Tommy John (6-2) S: Tom Henke (10) | First | -- |
| Thursday, June 11 |
| » Defeated Orioles (27-32), 8-6 | Memorial Stadium (1-0) | 37-20 | Won 9 |
| » W: Joe Johnson (3-5) L: John Habyan (1-2) S: Tom Henke (11) | First | -- |
| Friday, June 12 |
| » Defeated Orioles (27-33), 8-5 | Memorial Stadium (2-0) | 38-20 | Won 10 |
| » W: Mark Eichhorn (8-2) L: Mike Boddicker (5-3) S: Jeff Musselman (2) | First | -- |
| Saturday, June 13 |
| » Defeated Orioles (27-34), 8-2 | Memorial Stadium (3-0) | 39-20 | Won 11 |
| » W: John Cerutti (4-2) L: Scott McGregor (2-6) | First | -- |
| Sunday, June 14 |
| » Lost to Orioles (28-34), 8-5 | Memorial Stadium (3-1) | 39-21 | |
| » W: Dave J. Schmidt (7-1) L: Mark Eichhorn (8-3) S: Luis DeLeon (1) | First | -- |
| Monday, June 15 |
| » Lost to Tigers (33-27), 2-1 | Exhibition Stadium (19-9) | 39-22 | Lost 2 |
| » W: Walt Terrell (5-6) L: Jimmy Key (8-4) S: Eric King (4) | First | -- |
| Tuesday, June 16 |
| » Defeated Tigers (33-28), 10-4 | Exhibition Stadium (20-9) | 40-22 | |
| » W: Gary Lavelle (1-0) L: Jeff Robinson (4-3) | First | -- |
| Wednesday, June 17 |
| » Lost to Tigers (34-28), 3-2 | Exhibition Stadium (20-10) | 40-23 | |
| » W: Frank Tanana (6-3) L: Jim Clancy (7-4) S: Guillermo Hernandez (2) | First | -- |
| Thursday, June 18 |
| » Lost to Brewers (34-28), 6-3 | Exhibition Stadium (20-11) | 40-24 | Lost 2 |
| » W: Juan Nieves (5-4) L: Dave Stieb (5-4) S: Dan Plesac (15) | First | -- |
| Friday, June 19 |
| » Defeated Brewers (34-29), 15-6 | Exhibition Stadium (21-11) | 41-24 | |
| » W: Jeff Musselman (5-1) L: Mark Clear (5-2) | First | -- |
| Saturday, June 20 |
| » Lost to Brewers (35-29), 3-2 | Exhibition Stadium (21-12) | 41-25 | |
| » W: Bill Wegman (6-6) L: Jimmy Key (8-5) S: Dan Plesac (16) | First | -- |
| Sunday, June 21 |
| » Defeated Brewers (35-30), 7-6 | Exhibition Stadium (22-12) | 42-25 | |
| » W: Jeff Musselman (6-1) L: Chuck Crim (3-5) S: Tom Henke (12) | First | -- |
| Monday, June 22 |
| » Lost to Tigers (37-29), 2-0 | Tiger Stadium (0-1) | 42-26 | |
| » W: Frank Tanana (7-3) L: Jim Clancy (7-5) | First | -- |
| Tuesday, June 23 |
| » Defeated Tigers (37-30), 8-7 | Tiger Stadium (1-1) | 43-26 | |
| » W: Dave Stieb (6-4) L: Jeff Robinson (4-4) S: Tom Henke (13) | First | -- |
| Wednesday, June 24 |
| » Defeated Tigers (37-31), 5-3 | Tiger Stadium (2-1) | 44-26 | Won 2 |
| » W: John Cerutti (5-2) L: Jack Morris (10-3) S: Jeff Musselman (3) | First | -- |
| Friday, June 26 |
| » Lost to Brewers (36-33), 10-5 | County Stadium (0-1) | 44-27 | |
| » W: Dan Plesac (4-0) L: Tom Henke (0-2) | First | -- |
| Saturday, June 27 |
| » Defeated Brewers (36-34), 8-1 | County Stadium (1-1) | 45-27 | |
| » W: Jim Clancy (8-5) L: Juan Nieves (5-5) | First | -- |
| Sunday, June 28 |
| » Lost to Brewers (37-34), 11-5 | County Stadium (1-2) | 45-28 | |
| » W: Teddy Higuera (6-7) L: Dave Stieb (6-5) | First | -- |
| Monday, June 29 |
| » Lost to Yankees (47-29), 15-14 | Exhibition Stadium (22-13) | 45-29 | Lost 2 |
| » W: Dave Righetti (5-3) L: Tom Henke (0-3) | Second | 1 out |
| Tuesday, June 30 |
| » Lost to Yankees (48-29), 4-0 | Exhibition Stadium (22-14) | 45-30 | Lost 3 |
| » W: Ron Guidry (1-3) L: David Wells (0-1) | Second | 2 out |
| » Major-league debuts: David Wells (Blue Jays) |
| Wednesday, July 1 |
| » Lost to Yankees (49-29), 6-1 | Exhibition Stadium (22-15) | 45-31 | Lost 4 |
| » W: Pat Clements (2-0) L: Jeff Musselman (6-2) | Second | 3 out |
| Friday, July 3 |
| » Lost to Royals (42-35), 6-4 | Royals Stadium (0-3) | 45-32 | Lost 5 |
| » W: Mark Gubicza (7-8) L: Jim Clancy (8-6) S: Jerry Gleaton (4) | Second | 4 out |
| » Lost to Royals (43-35), 5-4 | Royals Stadium (0-4) | 45-33 | Lost 6 |
| » W: Steve Farr (3-2) L: Tom Henke (0-4) | Second | 4 out |
| Saturday, July 4 |
| » Lost to Royals (44-35), 9-1 | Royals Stadium (0-5) | 45-34 | Lost 7 |
| » W: Buddy Black (4-2) L: David Wells (0-2) S: Bob Stoddard (1) | Second | 5 out |
| Sunday, July 5 |
| » Lost to Royals (45-35), 4-3 | Royals Stadium (0-6) | 45-35 | Lost 8 |
| » W: Dan Quisenberry (4-0) L: Mark Eichhorn (8-4) | Third | 5 out |
| Monday, July 6 |
| » Defeated Rangers (38-42), 6-4 | Exhibition Stadium (23-15) | 46-35 | |
| » W: Jimmy Key (9-5) L: Charlie Hough (9-4) S: Tom Henke (14) | Second | 4 out |
| Tuesday, July 7 |
| » Defeated Rangers (38-43), 6-2 | Exhibition Stadium (24-15) | 47-35 | Won 2 |
| » W: Jim Clancy (9-6) L: Mike Loynd (1-5) S: Tom Henke (15) | Second | 4 out |
| Wednesday, July 8 |
| » Defeated Rangers (38-44), 5-2 | Exhibition Stadium (25-15) | 48-35 | Won 3 |
| » W: Jeff Musselman (7-2) L: Bobby Witt (4-4) S: Tom Henke (16) | Second | 4 out |
| Thursday, July 9 |
| » Defeated Royals (45-39), 7-1 | Exhibition Stadium (26-15) | 49-35 | Won 4 |
| » W: Jose Nunez (1-0) L: Buddy Black (4-3) | Second | 3 out |
| Friday, July 10 |
| » Defeated Royals (45-40), 7-0 | Exhibition Stadium (27-15) | 50-35 | Won 5 |
| » W: Dave Stieb (7-5) L: Charlie Leibrandt (8-7) | Second | 3 out |
| Saturday, July 11 |
| » Lost to Royals (46-40), 2-1 | Exhibition Stadium (27-16) | 50-36 | |
| » W: Bret Saberhagen (15-3) L: Jimmy Key (9-6) | Second | 3 out |
| Sunday, July 12 |
| » Defeated Royals (46-41), 3-2 | Exhibition Stadium (28-16) | 51-36 | |
| » W: Jim Clancy (10-6) L: Buddy Black (4-4) S: Tom Henke (17) | Second | 3 out |
| Thursday, July 16 |
| » Defeated Twins (49-41), 5-2 | Hubert H. Humphrey Metrodome (3-0) | 52-36 | Won 2 |
| » W: Jimmy Key (10-6) L: Bert Blyleven (8-7) S: Tom Henke (18) | Second | 3 out |
| Friday, July 17 |
| » Lost to Twins (50-41), 3-2 | Hubert H. Humphrey Metrodome (3-1) | 52-37 | |
| » W: Frank Viola (9-6) L: Mark Eichhorn (8-5) S: Jeff Reardon (18) | Second | 4 out |
| Saturday, July 18 |
| » Defeated Twins (50-42), 7-5 | Hubert H. Humphrey Metrodome (4-1) | 53-37 | |
| » W: Dave Stieb (8-5) L: Joe Niekro (5-7) | Second | 3 out |
| Sunday, July 19 |
| » Lost to Twins (51-42), 7-6 | Hubert H. Humphrey Metrodome (4-2) | 53-38 | |
| » W: Dan Schatzeder (4-1) L: Gary Lavelle (1-1) S: Jeff Reardon (19) | Second | 3 out |
| Monday, July 20 |
| » Defeated Rangers (43-48), 5-3 | Arlington Stadium (3-1) | 54-38 | |
| » W: John Cerutti (6-2) L: Charlie Hough (10-6) S: Tom Henke (19) | Second | 3 out |
| Tuesday, July 21 |
| » Lost to Rangers (44-48), 6-4 | Arlington Stadium (3-2) | 54-39 | |
| » W: Dale Mohorcic (6-2) L: Jeff Musselman (7-3) | Third | 3 out |
| Wednesday, July 22 |
| » Lost to Rangers (45-48), 5-3 | Arlington Stadium (3-3) | 54-40 | Lost 2 |
| » W: Jeff Russell (3-1) L: Gary Lavelle (1-2) S: Dale Mohorcic (13) | Third | 3 out |
| Thursday, July 23 |
| » Defeated Twins (53-44), 4-3 | Exhibition Stadium (29-16) | 55-40 | |
| » W: Dave Stieb (9-5) L: George Frazier (5-5) | Second | 2½ out |
| Friday, July 24 |
| » Defeated Twins (53-45), 8-6 | Exhibition Stadium (30-16) | 56-40 | Won 2 |
| » W: Mark Eichhorn (9-5) L: Jeff Reardon (5-5) S: Tom Henke (20) | Second | 1½ out |
| Saturday, July 25 |
| » Lost to Twins (54-45), 13-9 | Exhibition Stadium (30-17) | 56-41 | |
| » W: Dan Schatzeder (5-1) L: Jeff Musselman (7-4) | Third | 1½ out |
| Sunday, July 26 |
| » Defeated Twins (54-46), 4-2 | Exhibition Stadium (31-17) | 57-41 | |
| » W: Jimmy Key (11-6) L: Bert Blyleven (9-8) S: Tom Henke (21) | Third | 1½ out |
| Monday, July 27 |
| » Defeated Red Sox (46-53), 10-8 | Exhibition Stadium (32-17) | 58-41 | Won 2 |
| » W: Jeff Musselman (8-4) L: Calvin Schiraldi (5-5) S: Tom Henke (22) | Third | 1 out |
| Tuesday, July 28 |
| » Defeated Red Sox (46-54), 5-4 | Exhibition Stadium (33-17) | 59-41 | Won 3 |
| » W: Jeff Musselman (9-4) L: Joe Sambito (1-3) S: Tom Henke (23) | Third | 1 out |
| Wednesday, July 29 |
| » Lost to Red Sox (47-54), 6-5 | Exhibition Stadium (33-18) | 59-42 | |
| » W: Calvin Schiraldi (6-5) L: Gary Lavelle (1-3) | Third | 2 out |
| Friday, July 31 |
| » Defeated Indians (36-66), 8-3 | Exhibition Stadium (34-18) | 60-42 | |
| » W: Jimmy Key (12-6) L: Reggie Ritter (0-1) | Second | 2½ out |
| Saturday, August 1 |
| » Lost to Indians (37-66), 3-0 | Exhibition Stadium (34-19) | 60-43 | |
| » W: Scott Bailes (4-4) L: Jim Clancy (10-7) S: Sammy Stewart (2) | Third | 2½ out |
| Sunday, August 2 |
| » Defeated Indians (37-67), 11-5 | Exhibition Stadium (35-19) | 61-43 | |
| » W: Dave Stieb (10-5) L: Darrel Akerfelds (0-2) S: Gary Lavelle (1) | Second | 2½ out |
| Monday, August 3 |
| » Defeated White Sox (43-60), 14-5 | Comiskey Park I (3-1) | 62-43 | Won 2 |
| » W: Jeff Musselman (10-4) L: Floyd Bannister (6-9) | Second | 1½ out |
| Tuesday, August 4 |
| » Defeated White Sox (43-61), 4-1 | Comiskey Park I (4-1) | 63-43 | Won 3 |
| » W: John Cerutti (7-2) L: Neil Allen (0-6) S: Tom Henke (24) | Second | ½ out |
| Wednesday, August 5 |
| » Defeated White Sox (43-62), 3-2 | Comiskey Park I (5-1) | 64-43 | Won 4 |
| » W: Jimmy Key (13-6) L: Richard Dotson (8-8) S: Tom Henke (25) | Second | ½ out |
| Thursday, August 6 |
| » Lost to Indians (40-68), 14-5 | Cleveland Stadium (2-2) | 64-44 | |
| » W: Scott Bailes (5-4) L: Jim Clancy (10-8) | Second | ½ out |
| Friday, August 7 |
| » Defeated Indians (40-69), 15-1 | Cleveland Stadium (3-2) | 65-44 | |
| » W: Dave Stieb (11-5) L: Darrel Akerfelds (0-3) | First | -- |
| Saturday, August 8 |
| » Lost to Indians (41-69), 3-1 | Cleveland Stadium (3-3) | 65-45 | |
| » W: Tom Candiotti (5-11) L: Jose Nunez (1-1) | Second | ½ out |
| Sunday, August 9 |
| » Defeated Indians (41-70), 5-1 | Cleveland Stadium (4-3) | 66-45 | |
| » W: John Cerutti (8-2) L: Ken Schrom (5-8) | First | -- |
| Monday, August 10 |
| » Lost to Red Sox (53-58), 9-1 | Fenway Park (1-3) | 66-46 | |
| » W: Roger Clemens (12-7) L: Jim Clancy (10-9) | First | -- |
| Tuesday, August 11 |
| » Defeated Red Sox (53-59), 8-3 | Fenway Park (2-3) | 67-46 | |
| » W: Jimmy Key (14-6) L: Bob Stanley (3-12) | First | -- |
| Wednesday, August 12 |
| » Defeated Red Sox (53-60), 10-4 | Fenway Park (3-3) | 68-46 | Won 2 |
| » W: Dave Stieb (12-5) L: Jeff Sellers (4-5) | First | -- |
| Thursday, August 13 |
| » Lost to White Sox (46-67), 10-3 | Exhibition Stadium (35-20) | 68-47 | |
| » W: Floyd Bannister (8-9) L: Phil Niekro (7-12) | First | -- |
| Friday, August 14 |
| » Defeated White Sox (46-68), 3-2 | Exhibition Stadium (36-20) | 69-47 | |
| » W: John Cerutti (9-2) L: Jose DeLeon (5-11) S: Tom Henke (26) | First | -- |
| Saturday, August 15 |
| » Lost to White Sox (47-68), 1-0 | Exhibition Stadium (36-21) | 69-48 | |
| » W: Richard Dotson (10-8) L: Jim Clancy (10-10) | First | -- |
| Sunday, August 16 |
| » Defeated White Sox (47-69), 6-4 | Exhibition Stadium (37-21) | 70-48 | |
| » W: Mark Eichhorn (10-5) L: Ray Searage (2-3) S: Tom Henke (27) | First | -- |
| Tuesday, August 18 |
| » Defeated Athletics (60-59), 2-1 | Oakland-Alameda County Stadium (2-2) | 71-48 | Won 2 |
| » W: Dave Stieb (13-5) L: Dennis Eckersley (6-6) S: Tom Henke (28) | First | -- |
| Wednesday, August 19 |
| » Lost to Athletics (61-59), 7-3 | Oakland-Alameda County Stadium (2-3) | 71-49 | |
| » W: Dave Stewart (17-8) L: John Cerutti (9-3) | Second | 1½ out |
| Thursday, August 20 |
| » Defeated Athletics (61-60), 7-6 | Oakland-Alameda County Stadium (3-3) | 72-49 | |
| » W: Gary Lavelle (2-3) L: Greg Cadaret (2-1) S: Tom Henke (29) | Second | 1½ out |
| Friday, August 21 |
| » Lost to Angels (61-62), 3-1 | Anaheim Stadium (1-3) | 72-50 | |
| » W: Jerry Reuss (4-6) L: Phil Niekro (7-13) S: Greg Minton (11) | Second | 1 out |
| Saturday, August 22 |
| » Defeated Angels (61-63), 2-0 | Anaheim Stadium (2-3) | 73-50 | |
| » W: Jose Nunez (2-1) L: Mike Witt (15-9) S: Tom Henke (30) | Second | 1 out |
| Sunday, August 23 |
| » Lost to Angels (62-63), 5-2 | Anaheim Stadium (2-4) | 73-51 | |
| » W: Kirk McCaskill (4-5) L: Dave Stieb (13-6) S: DeWayne Buice (14) | Second | 1 out |
| Monday, August 24 |
| » Defeated Mariners (59-66), 7-3 | Kingdome (4-1) | 74-51 | |
| » W: John Cerutti (10-3) L: Mike Morgan (10-14) | Second | 1 out |
| Tuesday, August 25 |
| » Defeated Mariners (59-67), 6-3 | Kingdome (5-1) | 75-51 | Won 2 |
| » W: Jim Clancy (11-10) L: Mike Moore (6-16) S: Mark Eichhorn (4) | Second | 1 out |
| » Major-league debuts: Nelson Liriano (Blue Jays) |
| Thursday, August 27 |
| » Defeated Athletics (65-62), 9-4 | Exhibition Stadium (38-21) | 76-51 | Won 3 |
| » W: Jimmy Key (15-6) L: Greg Cadaret (3-2) | Second | 1 out |
| Friday, August 28 |
| » Lost to Athletics (66-62), 3-2 | Exhibition Stadium (38-22) | 76-52 | |
| » W: Dave Stewart (18-9) L: Dave Stieb (13-7) S: Dennis Eckersley (10) | Second | 1 out |
| Saturday, August 29 |
| » Lost to Athletics (67-62), 6-5 | Exhibition Stadium (38-23) | 76-53 | Lost 2 |
| » W: Eric Plunk (2-4) L: Mark Eichhorn (10-6) S: Dennis Eckersley (11) | Second | 1 out |
| Sunday, August 30 |
| » Defeated Athletics (67-63), 13-3 | Exhibition Stadium (39-23) | 77-53 | |
| » W: Jim Clancy (12-10) L: Jose Rijo (2-7) | Second | 1 out |
| Monday, August 31 |
| » Lost to Angels (66-66), 8-7 | Exhibition Stadium (39-24) | 77-54 | |
| » W: Willie Fraser (9-8) L: Tom Henke (0-5) S: Gary Lucas (3) | Second | 1 out |
| Tuesday, September 1 |
| » Defeated Angels (66-67), 4-3 | Exhibition Stadium (40-24) | 78-54 | |
| » W: Jeff Musselman (11-4) L: Mike Witt (15-10) | Second | 1 out |
| Wednesday, September 2 |
| » Defeated Angels (66-68), 7-6 | Exhibition Stadium (41-24) | 79-54 | Won 2 |
| » W: David Wells (1-2) L: DeWayne Buice (5-6) | Second | 1 out |
| Friday, September 4 |
| » Defeated Mariners (63-71), 6-5 | Exhibition Stadium (42-24) | 80-54 | Won 3 |
| » W: Jose Nunez (3-1) L: Dennis Powell (0-3) | Second | 1½ out |
| Saturday, September 5 |
| » Defeated Mariners (63-72), 3-0 | Exhibition Stadium (43-24) | 81-54 | Won 4 |
| » W: Mike Flanagan (4-6) L: Mike Campbell (0-3) S: Tom Henke (31) | Second | ½ out |
| Sunday, September 6 |
| » Defeated Mariners (63-73), 3-2 | Exhibition Stadium (44-24) | 82-54 | Won 5 |
| » W: Jose Nunez (4-1) L: Ed Nunez (3-3) | First | -- |
| Monday, September 7 |
| » Defeated Brewers (74-63), 5-3 | County Stadium (2-2) | 83-54 | Won 6 |
| » W: Duane Ward (1-0) L: Dan Plesac (5-6) S: Tom Henke (32) | First | -- |
| Tuesday, September 8 |
| » Lost to Brewers (75-63), 6-4 | County Stadium (2-3) | 83-55 | |
| » W: Chris Bosio (10-5) L: Dave Stieb (13-8) S: Chuck Crim (9) | Second | 1 out |
| Wednesday, September 9 |
| » Lost to Brewers (76-63), 6-4 | County Stadium (2-4) | 83-56 | Lost 2 |
| » W: Mark Clear (7-5) L: David Wells (1-3) | Second | 1½ out |
| Thursday, September 10 |
| » Major-league debuts: Jose Mesa (Orioles) |
| Friday, September 11 |
| » Defeated Yankees (78-62), 6-5 | Exhibition Stadium (45-24) | 84-56 | |
| » W: David Wells (2-3) L: Dave Righetti (7-4) | First | -- |
| » Major-league debuts: Jay Buhner and Orestes Destrade (Yankees) |
| Saturday, September 12 |
| » Defeated Yankees (78-63), 13-1 | Exhibition Stadium (46-24) | 85-56 | Won 2 |
| » W: Jimmy Key (16-6) L: Rick Rhoden (16-10) | First | -- |
| » Major-league debuts: Greg Myers (Blue Jays) |
| Sunday, September 13 |
| » Lost to Yankees (79-63), 8-5 | Exhibition Stadium (46-25) | 85-57 | |
| » W: Charles Hudson (10-6) L: John Cerutti (10-4) S: Dave Righetti (27) | First | -- |
| Monday, September 14 |
| » Defeated Orioles (62-81), 18-3 | Exhibition Stadium (47-25) | 86-57 | |
| » W: Jim Clancy (13-10) L: Ken Dixon (7-10) | First | -- |
| Tuesday, September 15 |
| » Defeated Orioles (62-82), 6-2 | Exhibition Stadium (48-25) | 87-57 | Won 2 |
| » W: Mike Flanagan (5-6) L: Jose Mesa (0-1) | First | -- |
| Wednesday, September 16 |
| » Defeated Orioles (62-83), 7-0 | Exhibition Stadium (49-25) | 88-57 | Won 3 |
| » W: Jimmy Key (17-6) L: Mike Boddicker (10-9) | First | -- |
| Thursday, September 17 |
| » Lost to Yankees (81-65), 6-5 | Yankee Stadium (3-1) | 88-58 | |
| » W: Dave Righetti (8-4) L: Tom Henke (0-6) | Second | ½ out |
| Friday, September 18 |
| » Defeated Yankees (81-66), 6-3 | Yankee Stadium (4-1) | 89-58 | |
| » W: Jim Clancy (14-10) L: Neil Allen (0-8) S: David Wells (1) | Second | ½ out |
| Saturday, September 19 |
| » Lost to Yankees (82-66), 4-2 | Yankee Stadium (4-2) | 89-59 | |
| » W: Bill Gullickson (13-13) L: Mike Flanagan (5-7) S: Dave Righetti (29) | Second | 1½ out |
| Sunday, September 20 |
| » Defeated Yankees (82-67), 6-2 | Yankee Stadium (5-2) | 90-59 | |
| » W: David Wells (3-3) L: Al Leiter (1-1) | Second | ½ out |
| Monday, September 21 |
| » Defeated Orioles (63-87), 2-1 | Memorial Stadium (4-1) | 91-59 | Won 2 |
| » W: John Cerutti (11-4) L: Mike Boddicker (10-10) S: Tom Henke (33) | First | -- |
| Tuesday, September 22 |
| » Defeated Orioles (63-88), 8-4 | Memorial Stadium (5-1) | 92-59 | Won 3 |
| » W: David Wells (4-3) L: Jeff Ballard (2-7) | First | -- |
| Wednesday, September 23 |
| » Defeated Orioles (63-89), 6-1 | Memorial Stadium (6-1) | 93-59 | Won 4 |
| » W: Jim Clancy (15-10) L: John Habyan (5-6) | First | -- |
| Thursday, September 24 |
| » Defeated Tigers (92-60), 4-3 | Exhibition Stadium (50-25) | 94-59 | Won 5 |
| » W: Mike Flanagan (6-7) L: Jack Morris (18-10) S: Tom Henke (34) | First | -- |
| Friday, September 25 |
|