| Tuesday, January 7 |
| Former White Sox Joe Burns dies in Trenton, NJ at the age of 86. |
| Sunday, January 12 |
| Former White Sox Eddie Solomon dies in Macon, GA at the age of 35. |
| Monday, January 13 |
| Former White Sox Mike Garcia dies in Fairview Park, OH at the age of 63. |
| Thursday, February 13 |
| Former White Sox Ed McGhee dies in Memphis, TN at the age of 62. |
| Friday, March 7 |
| Former White Sox Jimmy Moore dies in Memphis, TN at the age of 83. |
| Monday, April 7 |
| » Lost to Brewers (1-0), 5-3 | Comiskey Park I (0-1) | 0-1 | |
| » W: Teddy Higuera (1-0) L: Tom Seaver (0-1) S: Mark Clear (1) | Second | ½ out |
| Wednesday, April 9 |
| » Lost to Brewers (2-0), 4-3 | Comiskey Park I (0-2) | 0-2 | Lost 2 |
| » W: Tim Leary (1-0) L: Richard Dotson (0-1) S: Ray Searage (1) | Third | 2 out |
| » Major-league debuts: Bobby Bonilla (White Sox) |
| Thursday, April 10 |
| » Lost to Brewers (3-0), 8-5 | Comiskey Park I (0-3) | 0-3 | Lost 3 |
| » W: Danny Darwin (1-0) L: Bob James (0-1) | Third | 2 out |
| » Major-league debuts: Juan Nieves (Brewers) |
| Friday, April 11 |
| » Lost to Red Sox (2-2), 7-2 | Comiskey Park I (0-4) | 0-4 | Lost 4 |
| » W: Roger Clemens (1-0) L: Floyd Bannister (0-1) | Fourth | 3 out |
| Saturday, April 12 |
| » Defeated Red Sox (2-3), 3-1 | Comiskey Park I (1-4) | 1-4 | |
| » W: Tom Seaver (1-1) L: Bruce Hurst (0-1) S: Dave J. Schmidt (1) | Third | 2 out |
| Sunday, April 13 |
| » Lost to Red Sox (3-3), 12-2 | Comiskey Park I (1-5) | 1-5 | |
| » W: Tim Lollar (1-0) L: Joe Cowley (0-1) | Fourth | 3 out |
| Monday, April 14 |
| » Lost to Tigers (4-3), 10-8 | Comiskey Park I (1-6) | 1-6 | Lost 2 |
| » W: Dan Petry (1-1) L: Richard Dotson (0-2) S: Guillermo Hernandez (2) | Third | 3 out |
| Wednesday, April 16 |
| » Defeated Tigers (4-4), 10-4 | Comiskey Park I (2-6) | 2-6 | |
| » W: Floyd Bannister (1-1) L: Walt Terrell (1-1) | Fifth | 3 out |
| Thursday, April 17 |
| » Lost to Tigers (5-4), 10-6 | Comiskey Park I (2-7) | 2-7 | |
| » W: Jack Morris (2-1) L: Juan Agosto (0-1) S: Guillermo Hernandez (3) | Fifth | 3½ out |
| Friday, April 18 |
| » Lost to Red Sox (5-5), 2-1 | Fenway Park (0-1) | 2-8 | Lost 2 |
| » W: Bruce Hurst (1-1) L: Tom Seaver (1-2) | Sixth | 4½ out |
| Saturday, April 19 |
| » Lost to Red Sox (6-5), 3-2 | Fenway Park (0-2) | 2-9 | Lost 3 |
| » W: Oil Can Boyd (1-1) L: Juan Agosto (0-2) | Sixth | 4½ out |
| Sunday, April 20 |
| » Lost to Red Sox (7-5), 6-2 | Fenway Park (0-3) | 2-10 | Lost 4 |
| » W: Mike Brown (1-0) L: Floyd Bannister (1-2) | Sixth | 5½ out |
| Tuesday, April 22 |
| » Defeated Brewers (5-7), 5-4 | County Stadium (1-0) | 3-10 | |
| » W: Joel Davis (1-0) L: Danny Darwin (1-1) S: Bob James (1) | Seventh | 5 out |
| Wednesday, April 23 |
| » Defeated Brewers (5-8), 2-1 | County Stadium (2-0) | 4-10 | Won 2 |
| » W: Tom Seaver (2-2) L: Dan Plesac (1-1) S: Bob James (2) | Seventh | 5 out |
| Friday, April 25 |
| » Defeated Tigers (8-7), 9-7 | Tiger Stadium (1-0) | 5-10 | Won 3 |
| » W: Gene Nelson (1-0) L: Randy O'Neal (0-1) S: Bob James (3) | Seventh | 4 out |
| Saturday, April 26 |
| » Defeated Tigers (8-8), 5-4 | Tiger Stadium (2-0) | 6-10 | Won 4 |
| » W: Bob James (1-1) L: Bill Campbell (0-1) | Seventh | 4 out |
| Sunday, April 27 |
| » Lost to Tigers (9-8), 4-1 | Tiger Stadium (2-1) | 6-11 | |
| » W: Jack Morris (3-2) L: Joel Davis (1-1) | Seventh | 5 out |
| Monday, April 28 |
| Former White Sox Pat Seerey dies in Jennings, MO at the age of 64. |
| Tuesday, April 29 |
| » Lost to Orioles (10-9), 8-1 | Comiskey Park I (2-8) | 6-12 | Lost 2 |
| » W: Scott McGregor (2-2) L: Gene Nelson (1-1) | Seventh | 6 out |
| Wednesday, April 30 |
| » Defeated Orioles (10-10), 8-6 | Comiskey Park I (3-8) | 7-12 | |
| » W: Richard Dotson (1-2) L: Storm Davis (1-1) S: Bob James (4) | Fifth | 5 out |
| Friday, May 2 |
| » Lost to Indians (12-8), 7-5 | Comiskey Park I (3-9) | 7-13 | |
| » W: Ernie Camacho (1-0) L: Dave J. Schmidt (0-1) | Fifth | 5½ out |
| Saturday, May 3 |
| » Lost to Indians (13-8), 8-7 | Comiskey Park I (3-10) | 7-14 | Lost 2 |
| » W: Rich Yett (1-0) L: Bill Dawley (0-1) | Sixth | 5½ out |
| Sunday, May 4 |
| » Lost to Indians (14-8), 6-4 | Comiskey Park I (3-11) | 7-15 | Lost 3 |
| » W: Scott Bailes (4-1) L: Bob James (1-2) | Sixth | 5½ out |
| Monday, May 5 |
| » Lost to Yankees (16-9), 4-1 | Comiskey Park I (3-12) | 7-16 | Lost 4 |
| » W: Joe Niekro (4-0) L: Richard Dotson (1-3) S: Dave Righetti (6) | Sixth | 5½ out |
| Tuesday, May 6 |
| » Lost to Yankees (17-9), 10-6 | Comiskey Park I (3-13) | 7-17 | Lost 5 |
| » W: Brian Fisher (1-1) L: Bill Dawley (0-2) | Seventh | 6½ out |
| » Major-league debuts: Joel McKeon (White Sox) |
| Wednesday, May 7 |
| » Lost to Yankees (18-9), 5-1 | Comiskey Park I (3-14) | 7-18 | Lost 6 |
| » W: Tommy John (1-0) L: Floyd Bannister (1-3) S: Dave Righetti (7) | Seventh | 7½ out |
| Friday, May 9 |
| » Defeated Indians (17-9), 4-3 | Cleveland Stadium (1-0) | 8-18 | |
| » W: Gene Nelson (2-1) L: Scott Bailes (4-2) | Sixth | 6 out |
| Saturday, May 10 |
| » Defeated Indians (17-10), 4-0 | Cleveland Stadium (2-0) | 9-18 | Won 2 |
| » W: Gene Nelson (3-1) L: Scott Bailes (4-3) | Sixth | 5 out |
| Sunday, May 11 |
| » Defeated Indians (17-11), 5-4 | Cleveland Stadium (3-0) | 10-18 | Won 3 |
| » W: Joel McKeon (1-0) L: Tom Candiotti (2-3) S: Bob James (5) | Sixth | 5 out |
| Monday, May 12 |
| » Lost to Orioles (15-14), 4-3 | Memorial Stadium (0-1) | 10-19 | |
| » W: Rich Bordi (1-0) L: Bob James (1-3) | Seventh | 6 out |
| Tuesday, May 13 |
| » Lost to Orioles (16-14), 3-1 | Memorial Stadium (0-2) | 10-20 | Lost 2 |
| » W: Don Aase (2-2) L: Floyd Bannister (1-4) | Seventh | 7 out |
| Wednesday, May 14 |
| » Defeated Yankees (21-12), 3-2 | Yankee Stadium (1-0) | 11-20 | |
| » W: Joel McKeon (2-0) L: Brian Fisher (1-2) S: Bob James (6) | Seventh | 6 out |
| Thursday, May 15 |
| » Defeated Yankees (21-13), 8-1 | Yankee Stadium (2-0) | 12-20 | Won 2 |
| » W: Neil Allen (1-0) L: Ron Guidry (4-2) | Sixth | 5½ out |
| Friday, May 16 |
| » Defeated Royals (16-17), 4-2 | Comiskey Park I (4-14) | 13-20 | Won 3 |
| » W: Richard Dotson (2-3) L: Charlie Leibrandt (4-2) S: Bob James (7) | Fifth | 5½ out |
| Saturday, May 17 |
| » Defeated Royals (16-18), 7-6 | Comiskey Park I (5-14) | 14-20 | Won 4 |
| » W: Bob James (2-3) L: Mark Huismann (0-1) | Fifth | 4½ out |
| Sunday, May 18 |
| » Defeated Royals (16-19), 5-1 | Comiskey Park I (6-14) | 15-20 | Won 5 |
| » W: Floyd Bannister (2-4) L: Bret Saberhagen (2-4) | Fifth | 4 out |
| Tuesday, May 20 |
| » Defeated Blue Jays (17-22), 2-1 | Comiskey Park I (7-14) | 16-20 | Won 6 |
| » W: Joel Davis (2-1) L: John Cerutti (0-1) | Fifth | 4 out |
| Wednesday, May 21 |
| » Defeated Blue Jays (17-23), 5-4 | Comiskey Park I (8-14) | 17-20 | Won 7 |
| » W: Gene Nelson (4-1) L: Jim Acker (1-3) | Fourth | 3 out |
| Thursday, May 22 |
| » Lost to Blue Jays (18-23), 5-0 | Comiskey Park I (8-15) | 17-21 | |
| » W: Jimmy Key (3-3) L: Richard Dotson (2-4) | Fifth | 3 out |
| Friday, May 23 |
| » Defeated Royals (18-22), 4-1 | Royals Stadium (1-0) | 18-21 | |
| » W: Joe Cowley (1-1) L: Bret Saberhagen (2-5) S: Gene Nelson (1) | Fourth | 2 out |
| Saturday, May 24 |
| » Lost to Royals (19-22), 7-6 | Royals Stadium (1-1) | 18-22 | |
| » W: Buddy Black (3-3) L: Bob James (2-4) | Fifth | 2½ out |
| Sunday, May 25 |
| » Lost to Royals (20-22), 2-1 | Royals Stadium (1-2) | 18-23 | Lost 2 |
| » W: Scott Bankhead (1-0) L: Bill Dawley (0-3) | Fifth | 2½ out |
| » Major-league debuts: Scott Bankhead (Royals) |
| Monday, May 26 |
| » Lost to Rangers (22-21), 7-2 | Arlington Stadium (0-1) | 18-24 | Lost 3 |
| » W: Jose Guzman (4-5) L: Dave J. Schmidt (0-2) S: Greg Harris (7) | Fifth | 3½ out |
| Tuesday, May 27 |
| » Lost to Rangers (23-21), 6-3 | Arlington Stadium (0-2) | 18-25 | Lost 4 |
| » W: Charlie Hough (3-2) L: Richard Dotson (2-5) | Fifth | 4½ out |
| Wednesday, May 28 |
| » Lost to Rangers (24-21), 6-3 | Arlington Stadium (0-3) | 18-26 | Lost 5 |
| » W: Ed Correa (3-3) L: Joe Cowley (1-2) S: Mitch Williams (1) | Fifth | 5½ out |
| Friday, May 30 |
| » Lost to Blue Jays (22-26), 6-0 | Exhibition Stadium (0-1) | 18-27 | Lost 6 |
| » W: Dave Stieb (1-6) L: Joel Davis (2-2) | Sixth | 5½ out |
| Saturday, May 31 |
| » Lost to Blue Jays (23-26), 4-3 | Exhibition Stadium (0-2) | 18-28 | Lost 7 |
| » W: Tom Henke (4-3) L: Gene Nelson (4-2) | Sixth | 5½ out |
| Sunday, June 1 |
| » Defeated Blue Jays (23-27), 6-4 | Exhibition Stadium (1-2) | 19-28 | |
| » W: Richard Dotson (3-5) L: Jimmy Key (3-4) | Fourth | 4½ out |
| Monday, June 2 |
| » Lost to Rangers (25-24), 1-0 | Comiskey Park I (8-16) | 19-29 | |
| » W: Charlie Hough (4-2) L: Joe Cowley (1-3) S: Greg Harris (8) | Fifth | 5½ out |
| Tuesday, June 3 |
| » Lost to Rangers (26-24), 4-1 | Comiskey Park I (8-17) | 19-30 | Lost 2 |
| » W: Ed Correa (4-3) L: Joel Davis (2-3) S: Mitch Williams (2) | Fifth | 6½ out |
| Wednesday, June 4 |
| » Lost to Rangers (27-24), 5-2 | Comiskey Park I (8-18) | 19-31 | Lost 3 |
| » W: Bobby Witt (3-4) L: Tom Seaver (2-3) S: Mickey Mahler (3) | Sixth | 7½ out |
| Thursday, June 5 |
| » Defeated Athletics (25-29), 9-5 | Comiskey Park I (9-18) | 20-31 | |
| » W: Neil Allen (2-0) L: Moose Haas (7-2) | Fifth | 7 out |
| Friday, June 6 |
| » Defeated Athletics (25-30), 6-4 | Comiskey Park I (10-18) | 21-31 | Won 2 |
| » W: Richard Dotson (4-5) L: Rick Langford (1-5) S: Joel McKeon (1) | Fifth | 7 out |
| Saturday, June 7 |
| » Defeated Athletics (25-31), 10-3 | Comiskey Park I (11-18) | 22-31 | Won 3 |
| » W: Joe Cowley (2-3) L: Chris Codiroli (4-7) | Fifth | 7½ out |
| Sunday, June 8 |
| » Defeated Athletics (25-32), 8-5 | Comiskey Park I (12-18) | 23-31 | Won 4 |
| » W: Joel Davis (3-3) L: Curt Young (4-2) S: Dave J. Schmidt (2) | Fifth | 7½ out |
| Monday, June 9 |
| » Lost to Angels (28-28), 3-0 | Comiskey Park I (12-19) | 23-32 | |
| » W: Don Sutton (4-5) L: Tom Seaver (2-4) | Fourth | 7½ out |
| Tuesday, June 10 |
| » Defeated Angels (28-29), 7-3 | Comiskey Park I (13-19) | 24-32 | |
| » W: Neil Allen (3-0) L: Ron Romanick (3-4) S: Bob James (8) | Fourth | 7½ out |
| Wednesday, June 11 |
| » Lost to Angels (29-29), 12-11 | Comiskey Park I (13-20) | 24-33 | |
| » W: Kirk McCaskill (5-4) L: Richard Dotson (4-6) S: Terry Forster (3) | Third | 8½ out |
| Thursday, June 12 |
| » Defeated Mariners (22-39), 8-4 | Kingdome (1-0) | 25-33 | |
| » W: Joe Cowley (3-3) L: Lee Guetterman (0-2) | Fourth | 8 out |
| Friday, June 13 |
| » Lost to Mariners (23-39), 11-10 | Kingdome (1-1) | 25-34 | |
| » W: Matt Young (5-4) L: Bill Dawley (0-4) | Third | 9 out |
| Saturday, June 14 |
| » Lost to Mariners (24-39), 7-3 | Kingdome (1-2) | 25-35 | Lost 2 |
| » W: Mark Langston (6-5) L: Tom Seaver (2-5) S: Matt Young (3) | Fifth | 9 out |
| Sunday, June 15 |
| » Lost to Mariners (25-39), 10-5 | Kingdome (1-3) | 25-36 | Lost 3 |
| » W: Steve Fireovid (1-0) L: Joel McKeon (2-1) | Fourth | 9 out |
| Tuesday, June 17 |
| » Lost to Twins (26-37), 4-1 | Hubert H. Humphrey Metrodome (0-1) | 25-37 | Lost 4 |
| » W: Mike Smithson (6-5) L: Richard Dotson (4-7) S: Keith Atherton (1) | Fifth | 8½ out |
| Wednesday, June 18 |
| » Lost to Twins (27-37), 10-9 | Hubert H. Humphrey Metrodome (0-2) | 25-38 | Lost 5 |
| » W: Ron Davis (2-5) L: Gene Nelson (4-3) | Sixth | 8½ out |
| Thursday, June 19 |
| » Defeated Twins (27-38), 9-8 | Hubert H. Humphrey Metrodome (1-2) | 26-38 | |
| » W: Floyd Bannister (3-4) L: Allan Anderson (0-1) S: Bob James (9) | Sixth | 8½ out |
| Friday, June 20 |
| » Lost to Mariners (27-41), 5-3 | Comiskey Park I (13-21) | 26-39 | |
| » Manager: Doug Rader |
| » W: Mark Langston (7-5) L: Tom Seaver (2-6) S: Matt Young (4) | Sixth | 9½ out |
| Saturday, June 21 |
| » Defeated Mariners (27-42), 7-6 | Comiskey Park I (14-21) | 27-39 | |
| » W: Neil Allen (4-0) L: Bill Swift (1-4) S: Bill Dawley (1) | Fifth | 9½ out |
| Sunday, June 22 |
| » Defeated Mariners (27-43), 10-4 | Comiskey Park I (15-21) | 28-39 | Won 2 |
| » Manager: Jim Fregosi |
| » W: Richard Dotson (5-7) L: Mike Morgan (5-7) | Fourth | 9½ out |
| Monday, June 23 |
| » Defeated Twins (28-41), 11-2 | Comiskey Park I (16-21) | 29-39 | Won 3 |
| » W: Joe Cowley (4-3) L: Bert Blyleven (5-7) | Fourth | 8½ out |
| Tuesday, June 24 |
| » Lost to Twins (29-41), 2-1 | Comiskey Park I (16-22) | 29-40 | |
| » W: Allan Anderson (1-1) L: Joel Davis (3-4) | Third | 8½ out |
| Wednesday, June 25 |
| » Defeated Twins (29-42), 4-3 | Comiskey Park I (17-22) | 30-40 | |
| » W: Joel McKeon (3-1) L: Frank Viola (7-6) S: Bob James (10) | Fourth | 8½ out |
| Friday, June 27 |
| » Lost to Athletics (30-45), 8-6 | Oakland-Alameda County Stadium (0-1) | 30-41 | |
| » W: Bill Mooneyham (2-2) L: Gene Nelson (4-4) S: Steve Ontiveros (6) | Fourth | 8½ out |
| Saturday, June 28 |
| » Defeated Athletics (30-46), 4-1 | Oakland-Alameda County Stadium (1-1) | 31-41 | |
| » W: Richard Dotson (6-7) L: Curt Young (5-5) S: Bob James (11) | Fourth | 8½ out |
| Sunday, June 29 |
| » Defeated Athletics (30-47), 6-5 | Oakland-Alameda County Stadium (2-1) | 32-41 | Won 2 |
| » W: Bob James (3-4) L: Doug Bair (0-1) | Fourth | 7½ out |
| Monday, June 30 |
| » Defeated Angels (40-35), 4-3 | Anaheim Stadium (1-0) | 33-41 | Won 3 |
| » W: Joel Davis (4-4) L: Kirk McCaskill (8-5) S: Dave J. Schmidt (3) | Fourth | 6½ out |
| Tuesday, July 1 |
| » Defeated Angels (40-36), 5-3 | Anaheim Stadium (2-0) | 34-41 | Won 4 |
| » W: Floyd Bannister (4-4) L: Mike Cook (0-1) S: Bob James (12) | Fourth | 6 out |
| Wednesday, July 2 |
| » Lost to Angels (41-36), 4-3 | Anaheim Stadium (2-1) | 34-42 | |
| » W: Mike Witt (9-6) L: Neil Allen (4-1) | Fourth | 7 out |
| Friday, July 4 |
| » Defeated Yankees (44-36), 2-1 | Comiskey Park I (18-22) | 35-42 | |
| » W: Richard Dotson (7-7) L: Bob Tewksbury (5-3) | Fourth | 7 out |
| Saturday, July 5 |
| » Lost to Yankees (45-36), 8-0 | Comiskey Park I (18-23) | 35-43 | |
| » W: Dennis Rasmussen (9-2) L: Joe Cowley (4-4) | Fourth | 8 out |
| Sunday, July 6 |
| » Defeated Yankees (45-37), 5-2 | Comiskey Park I (19-23) | 36-43 | |
| » W: Floyd Bannister (5-4) L: Doug Drabek (0-2) S: Bob James (13) | Fourth | 7 out |
| Monday, July 7 |
| » Defeated Indians (43-36), 4-3 | Comiskey Park I (20-23) | 37-43 | Won 2 |
| » W: Bob James (4-4) L: Ernie Camacho (1-2) | Third | 6½ out |
| Tuesday, July 8 |
| » Defeated Indians (43-37), 6-2 | Comiskey Park I (21-23) | 38-43 | Won 3 |
| » W: Neil Allen (5-1) L: Bryan Oelkers (0-1) S: Dave J. Schmidt (4) | Third | 6½ out |
| Former White Sox Skeeter Webb dies in Meridian, MS at the age of 77. |
| Wednesday, July 9 |
| » Lost to Indians (44-37), 6-3 | Comiskey Park I (21-24) | 38-44 | |
| » W: Phil Niekro (6-6) L: Richard Dotson (7-8) | Third | 7½ out |
| Thursday, July 10 |
| » Lost to Orioles (45-39), 5-3 | Comiskey Park I (21-25) | 38-45 | Lost 2 |
| » W: Mike Flanagan (3-6) L: Joe Cowley (4-5) S: Brad Havens (1) | Third | 7½ out |
| Friday, July 11 |
| » Lost to Orioles (46-39), 4-2 | Comiskey Park I (21-26) | 38-46 | Lost 3 |
| » W: Ken Dixon (8-7) L: Floyd Bannister (5-5) S: Don Aase (23) | Fourth | 8½ out |
| Saturday, July 12 |
| » Defeated Orioles (46-40), 6-3 | Comiskey Park I (22-26) | 39-46 | |
| » W: Gene Nelson (5-4) L: Mike Boddicker (11-5) S: Dave J. Schmidt (5) | Fourth | 7½ out |
| Sunday, July 13 |
| » Defeated Orioles (46-41), 7-0 | Comiskey Park I (23-26) | 40-46 | Won 2 |
| » W: Neil Allen (6-1) L: Scott McGregor (6-8) | Third | 7½ out |
| Thursday, July 17 |
| » Lost to Yankees (51-39), 5-4 | Yankee Stadium (2-1) | 40-47 | |
| » W: Dennis Rasmussen (11-2) L: Richard Dotson (7-9) S: Dave Righetti (20) | Fourth | 7½ out |
| Friday, July 18 |
| » Lost to Yankees (52-39), 8-4 | Yankee Stadium (2-2) | 40-48 | Lost 2 |
| » W: Joe Niekro (8-6) L: Floyd Bannister (5-6) S: Dave Righetti (21) | Fourth | 7½ out |
| Saturday, July 19 |
| » Defeated Yankees (52-40), 8-3 | Yankee Stadium (3-2) | 41-48 | |
| » W: Joe Cowley (5-5) L: Scott Nielsen (2-1) S: Gene Nelson (2) | Third | 7½ out |
| Sunday, July 20 |
| » Defeated Yankees (52-41), 8-0 | Yankee Stadium (4-2) | 42-48 | Won 2 |
| » W: Neil Allen (7-1) L: Bob Shirley (0-4) | Third | 6½ out |
| Monday, July 21 |
| » Lost to Indians (49-41), 5-2 | Cleveland Stadium (3-1) | 42-49 | |
| » W: Rich Yett (4-0) L: Joel Davis (4-5) | Third | 6½ out |
| Tuesday, July 22 |
| » Lost to Indians (50-41), 8-4 | Cleveland Stadium (3-2) | 42-50 | Lost 2 |
| » W: Tom Candiotti (9-7) L: Richard Dotson (7-10) | Third | 6½ out |
| Wednesday, July 23 |
| » Lost to Indians (51-41), 7-2 | Cleveland Stadium (3-3) | 42-51 | Lost 3 |
| » W: Ken Schrom (11-2) L: Floyd Bannister (5-7) | Fourth | 7½ out |
| Thursday, July 24 |
| » Lost to Orioles (51-44), 12-6 | Memorial Stadium (0-3) | 42-52 | Lost 4 |
| » W: Mike Flanagan (5-6) L: Joe Cowley (5-6) | Fourth | 8 out |
| Friday, July 25 |
| » Lost to Orioles (52-44), 6-2 | Memorial Stadium (0-4) | 42-53 | Lost 5 |
| » W: Mike Boddicker (13-5) L: Neil Allen (7-2) S: Don Aase (26) | Fourth | 8 out |
| Former White Sox Ted Lyons dies in Sulphur, LA at the age of 86. |
| Saturday, July 26 |
| » Lost to Orioles (53-44), 2-1 | Memorial Stadium (0-5) | 42-54 | Lost 6 |
| » W: Rich Bordi (4-1) L: Dave J. Schmidt (0-3) | Fifth | 9 out |
| Sunday, July 27 |
| » Lost to Orioles (54-44), 11-3 | Memorial Stadium (0-6) | 42-55 | Lost 7 |
| » W: Scott McGregor (7-10) L: Richard Dotson (7-11) | Fifth | 10 out |
| Former White Sox Bud Hafey dies in Sacramento, CA at the age of 74. |
| Monday, July 28 |
| » Lost to Red Sox (59-39), 3-1 | Comiskey Park I (23-27) | 42-56 | Lost 8 |
| » W: Al Nipper (5-7) L: Floyd Bannister (5-8) | Fifth | 11 out |
| Tuesday, July 29 |
| » Defeated Red Sox (59-40), 4-1 | Comiskey Park I (24-27) | 43-56 | |
| » W: Joe Cowley (6-6) L: Jeff Sellers (3-6) S: Bob James (14) | Fourth | 10 out |
| Wednesday, July 30 |
| » Defeated Red Sox (59-41), 7-2 | Comiskey Park I (25-27) | 44-56 | Won 2 |
| » W: Jose DeLeon (2-3) L: Roger Clemens (17-3) S: Dave J. Schmidt (6) | Fourth | 10 out |
| Friday, August 1 |
| » Lost to Tigers (55-48), 5-4 | Comiskey Park I (25-28) | 44-57 | |
| » W: Walt Terrell (10-8) L: Richard Dotson (7-12) S: Guillermo Hernandez (20) | Fourth | 11½ out |
| Saturday, August 2 |
| » Defeated Tigers (55-49), 5-3 | Comiskey Park I (26-28) | 45-57 | |
| » W: Floyd Bannister (6-8) L: Jack Morris (12-7) | Fourth | 10½ out |
| Sunday, August 3 |
| » Defeated Tigers (55-50), 10-1 | Comiskey Park I (27-28) | 46-57 | Won 2 |
| » W: Joe Cowley (7-6) L: Randy O'Neal (1-6) | Fourth | 9½ out |
| » Major-league debuts: Russ Morman (White Sox) |
| Monday, August 4 |
| » Defeated Red Sox (61-43), 1-0 | Fenway Park (1-3) | 47-57 | Won 3 |
| » W: Jose DeLeon (3-3) L: Roger Clemens (17-4) S: Dave J. Schmidt (7) | Third | 8½ out |
| Tuesday, August 5 |
| » Defeated Red Sox (61-44), 3-1 | Fenway Park (2-3) | 48-57 | Won 4 |
| » W: Richard Dotson (8-12) L: Oil Can Boyd (11-7) S: Gene Nelson (3) | Third | 8½ out |
| Wednesday, August 6 |
| » Lost to Red Sox (62-44), 9-0 | Fenway Park (2-4) | 48-58 | |
| » W: Bruce Hurst (7-5) L: Floyd Bannister (6-9) | Third | 8½ out |
| » Major-league debuts: Bobby Thigpen (White Sox) |
| Friday, August 8 |
| » Defeated Brewers (53-55), 12-6 | County Stadium (3-0) | 49-58 | |
| » W: Joe Cowley (8-6) L: Danny Darwin (6-8) S: Gene Nelson (4) | Third | 9 out |
| Saturday, August 9 |
| » Lost to Brewers (54-55), 1-0 | County Stadium (3-1) | 49-59 | |
| » W: Teddy Higuera (15-7) L: Jose DeLeon (3-4) | Third | 10 out |
| Sunday, August 10 |
| » Lost to Brewers (55-55), 5-4 | County Stadium (3-2) | 49-60 | Lost 2 |
| » W: Mark Clear (3-4) L: Dave J. Schmidt (0-4) | Third | 11 out |
| Monday, August 11 |
| » Defeated Brewers (55-56), 6-1 | County Stadium (4-2) | 50-60 | |
| » W: Floyd Bannister (7-9) L: Chris Bosio (0-1) | Third | 10 out |
| Tuesday, August 12 |
| » Lost to Tigers (61-53), 7-3 | Tiger Stadium (2-2) | 50-61 | |
| » W: Mark Thurmond (6-8) L: Steve Carlton (5-12) | Fourth | 11 out |
| Wednesday, August 13 |
| » Lost to Tigers (62-53), 5-2 | Tiger Stadium (2-3) | 50-62 | Lost 2 |
| » W: Randy O'Neal (2-7) L: Joe Cowley (8-7) | Fourth | 11 out |
| Thursday, August 14 |
| » Defeated Tigers (62-54), 8-2 | Tiger Stadium (3-3) | 51-62 | |
| » W: Jose DeLeon (4-4) L: Frank Tanana (9-6) | Third | 10½ out |
| Friday, August 15 |
| » Lost to Brewers (57-58), 4-3 | Comiskey Park I (27-29) | 51-63 | |
| » W: Dan Plesac (8-6) L: Bill Dawley (0-5) | Third | 11½ out |
| Saturday, August 16 |
| » Lost to Brewers (58-58), 6-5 | Comiskey Park I (27-30) | 51-64 | Lost 2 |
| » W: John Henry Johnson (1-1) L: Gene Nelson (5-5) S: Mark Clear (11) | Fourth | 12½ out |
| Sunday, August 17 |
| » Defeated Brewers (58-59), 7-4 | Comiskey Park I (28-30) | 52-64 | |
| » W: Steve Carlton (6-12) L: Bryan Clutterbuck (0-1) S: Bobby Thigpen (1) | Fourth | 12½ out |
| » Major-league debuts: Ron Karkovice (White Sox) Mike Birkbeck (Brewers) |
| Tuesday, August 19 |
| » Lost to Blue Jays (64-56), 5-1 | Exhibition Stadium (1-3) | 52-65 | |
| » W: Dave Stieb (4-10) L: Joe Cowley (8-8) | Fourth | 13 out |
| Wednesday, August 20 |
| » Lost to Blue Jays (65-56), 4-1 | Exhibition Stadium (1-4) | 52-66 | Lost 2 |
| » W: Joe Johnson (9-8) L: Jose DeLeon (4-5) | Fourth | 13 out |
| Thursday, August 21 |
| » Defeated Blue Jays (65-57), 4-3 | Exhibition Stadium (2-4) | 53-66 | |
| » W: Dave J. Schmidt (1-4) L: Jimmy Key (11-9) S: Gene Nelson (5) | Fourth | 13 out |
| Friday, August 22 |
| » Lost to Rangers (63-59), 11-3 | Arlington Stadium (0-4) | 53-67 | |
| » W: Jeff Russell (5-2) L: Floyd Bannister (7-10) | Fourth | 13 out |
| Saturday, August 23 |
| » Lost to Rangers (64-59), 3-1 | Arlington Stadium (0-5) | 53-68 | Lost 2 |
| » W: Jose Guzman (9-11) L: Steve Carlton (6-13) S: Mitch Williams (4) | Fifth | 13 out |
| Sunday, August 24 |
| » Lost to Rangers (65-59), 3-2 | Arlington Stadium (0-6) | 53-69 | Lost 3 |
| » W: Charlie Hough (11-8) L: Dave J. Schmidt (1-5) S: Mitch Williams (5) | Fifth | 14 out |
| Monday, August 25 |
| » Lost to Royals (57-68), 2-0 | Comiskey Park I (28-31) | 53-70 | Lost 4 |
| » W: Scott Bankhead (7-7) L: Jose DeLeon (4-6) S: Buddy Black (6) | Sixth | 15 out |
| Tuesday, August 26 |
| » Lost to Royals (58-68), 6-1 | Comiskey Park I (28-32) | 53-71 | Lost 5 |
| » W: Charlie Leibrandt (11-10) L: Richard Dotson (8-13) | Sixth | 16 out |
| Wednesday, August 27 |
| » Defeated Royals (58-69), 3-1 | Comiskey Park I (29-32) | 54-71 | |
| » W: Floyd Bannister (8-10) L: Danny Jackson (9-9) | Sixth | 15½ out |
| Thursday, August 28 |
| » Defeated Rangers (67-61), 6-2 | Comiskey Park I (30-32) | 55-71 | Won 2 |
| » W: Steve Carlton (7-13) L: Jose Guzman (9-12) S: Bobby Thigpen (2) | Sixth | 15½ out |
| Friday, August 29 |
| » Lost to Rangers (68-61), 5-2 | Comiskey Park I (30-33) | 55-72 | |
| » W: Charlie Hough (12-8) L: Joe Cowley (8-9) S: Mitch Williams (7) | Sixth | 16½ out |
| Saturday, August 30 |
| » Lost to Rangers (69-61), 6-2 | Comiskey Park I (30-34) | 55-73 | Lost 2 |
| » W: Bobby Witt (7-9) L: Jose DeLeon (4-7) | Sixth | 17½ out |
| Sunday, August 31 |
| » Defeated Rangers (69-62), 3-1 | Comiskey Park I (31-34) | 56-73 | |
| » W: Richard Dotson (9-13) L: Mike Loynd (2-2) S: Bobby Thigpen (3) | Sixth | 17½ out |
| Monday, September 1 |
| » Defeated Royals (60-71), 4-0 | Royals Stadium (2-2) | 57-73 | Won 2 |
| » W: Floyd Bannister (9-10) L: Charlie Leibrandt (11-11) | Fifth | 16½ out |
| Tuesday, September 2 |
| » Defeated Royals (60-72), 3-0 | Royals Stadium (3-2) | 58-73 | Won 3 |
| » W: Steve Carlton (8-13) L: Danny Jackson (9-10) S: Bobby Thigpen (4) | Fifth | 16½ out |
| » Major-league debuts: Bo Jackson (Royals) Dave Cochrane and Ken Williams (White Sox) |
| Former White Sox Jim Wilson dies in Newport Beach, CA at the age of 65. |
| Wednesday, September 3 |
| » Lost to Royals (61-72), 2-1 | Royals Stadium (3-3) | 58-74 | |
| » W: Buddy Black (5-7) L: Gene Nelson (5-6) | Fifth | 17½ out |
| » Major-league debuts: Kevin Seitzer (Royals) |
| Thursday, September 4 |
| » Lost to Royals (62-72), 1-0 | Royals Stadium (3-4) | 58-75 | Lost 2 |
| » W: Steve Farr (8-3) L: Bill Dawley (0-6) | Sixth | 18 out |
| Friday, September 5 |
| » Defeated Blue Jays (75-60), 5-0 | Comiskey Park I (32-34) | 59-75 | |
| » W: Richard Dotson (10-13) L: Joe Johnson (10-9) | Sixth | 17 out |
| Saturday, September 6 |
| » Lost to Blue Jays (76-60), 4-0 | Comiskey Park I (32-35) | 59-76 | |
| » W: Jimmy Key (12-9) L: Floyd Bannister (9-11) | Sixth | 18 out |
| Sunday, September 7 |
| » Defeated Blue Jays (76-61), 4-3 | Comiskey Park I (33-35) | 60-76 | |
| » W: Gene Nelson (6-6) L: Jim Clancy (14-9) S: Bobby Thigpen (5) | Sixth | 18 out |
| Tuesday, September 9 |
| » Defeated Athletics (65-74), 4-1 | Comiskey Park I (34-35) | 61-76 | Won 2 |
| » W: Joe Cowley (9-9) L: Dave Stewart (9-2) S: Bobby Thigpen (6) | Fifth | 18 out |
| Wednesday, September 10 |
| » Lost to Athletics (66-74), 6-2 | Comiskey Park I (34-36) | 61-77 | |
| » W: Jose Rijo (7-10) L: Pete Filson (0-1) | Sixth | 19 out |
| Thursday, September 11 |
| » Lost to Athletics (67-74), 2-1 | Comiskey Park I (34-37) | 61-78 | Lost 2 |
| » W: Joaquin Andujar (10-6) L: Richard Dotson (10-14) | Sixth | 19½ out |
| Friday, September 12 |
| » Defeated Angels (80-59), 3-2 | Comiskey Park I (35-37) | 62-78 | |
| » W: Bobby Thigpen (1-0) L: Chuck Finley (2-1) | Sixth | 18½ out |
| Saturday, September 13 |
| » Lost to Angels (81-59), 3-2 | Comiskey Park I (35-38) | 62-79 | |
| » W: Gary Lucas (3-0) L: Bill Dawley (0-7) S: Terry Forster (5) | Sixth | 19½ out |
| » Major-league debuts: Mark McLemore (Angel |