| Monday, April 7 |
| » Major-league debuts: John Kruk (Padres) |
| Tuesday, April 8 |
| » Defeated Athletics (0-1), 3-2 | Oakland-Alameda County Stadium (1-0) | 1-0 | |
| » W: Frank Viola (1-0) L: Chris Codiroli (0-1) S: Ron Davis (1) | First | -- |
| Wednesday, April 9 |
| » Defeated Athletics (0-2), 5-4 | Oakland-Alameda County Stadium (2-0) | 2-0 | Won 2 |
| » W: Mike Smithson (1-0) L: Jay Howell (0-1) | First | -- |
| Thursday, April 10 |
| » Lost to Athletics (1-2), 3-0 | Oakland-Alameda County Stadium (2-1) | 2-1 | |
| » W: Moose Haas (1-0) L: John Butcher (0-1) S: Jay Howell (1) | First | -- |
| Friday, April 11 |
| » Defeated Mariners (2-2), 5-1 | Hubert H. Humphrey Metrodome (1-0) | 3-1 | |
| » W: Bert Blyleven (1-0) L: Milt Wilcox (0-1) S: Ron Davis (2) | First | -- |
| Saturday, April 12 |
| » Lost to Mariners (3-2), 10-4 | Hubert H. Humphrey Metrodome (1-1) | 3-2 | |
| » W: Mike Morgan (1-0) L: Frank Viola (1-1) | First | -- |
| Sunday, April 13 |
| » Lost to Mariners (4-2), 4-2 | Hubert H. Humphrey Metrodome (1-2) | 3-3 | Lost 2 |
| » W: Mike Moore (1-0) L: Mike Smithson (1-1) | Second | 1 out |
| Monday, April 14 |
| » Lost to Athletics (3-4), 7-6 | Hubert H. Humphrey Metrodome (1-3) | 3-4 | Lost 3 |
| » W: Keith Atherton (1-0) L: Roy Smith (0-1) S: Jay Howell (2) | Second | 1 out |
| Tuesday, April 15 |
| » Lost to Athletics (4-4), 8-2 | Hubert H. Humphrey Metrodome (1-4) | 3-5 | Lost 4 |
| » W: Moose Haas (2-0) L: Bill Latham (0-1) | Fourth | 2 out |
| Wednesday, April 16 |
| » Defeated Athletics (4-5), 7-5 | Hubert H. Humphrey Metrodome (2-4) | 4-5 | |
| » W: Ron Davis (1-0) L: Keith Atherton (1-1) | Fourth | 1½ out |
| Thursday, April 17 |
| » Defeated Angels (5-5), 4-1 | Anaheim Stadium (1-0) | 5-5 | Won 2 |
| » W: Frank Viola (2-1) L: Kirk McCaskill (1-1) | Third | 1 out |
| Friday, April 18 |
| » Lost to Angels (6-5), 6-5 | Anaheim Stadium (1-1) | 5-6 | |
| » W: Mike Witt (1-1) L: Mike Smithson (1-2) S: Donnie Moore (1) | Fifth | 2 out |
| Saturday, April 19 |
| » Lost to Angels (7-5), 5-4 | Anaheim Stadium (1-2) | 5-7 | Lost 2 |
| » W: Jim Slaton (2-0) L: John Butcher (0-2) S: Donnie Moore (2) | Fifth | 2 out |
| Sunday, April 20 |
| » Lost to Angels (8-5), 8-5 | Anaheim Stadium (1-3) | 5-8 | Lost 3 |
| » W: Terry Forster (1-0) L: Ron Davis (1-1) | Fifth | 3 out |
| Monday, April 21 |
| » Defeated Mariners (5-8), 5-2 | Kingdome (1-0) | 6-8 | |
| » W: Frank Viola (3-1) L: Milt Wilcox (0-3) | Fifth | 2½ out |
| Tuesday, April 22 |
| » Defeated Mariners (5-9), 7-1 | Kingdome (2-0) | 7-8 | Won 2 |
| » W: Mike Smithson (2-2) L: Mike Morgan (1-1) | Fifth | 2 out |
| Wednesday, April 23 |
| » Lost to Mariners (6-9), 4-3 | Kingdome (2-1) | 7-9 | |
| » W: Karl Best (1-0) L: Mark Portugal (0-1) | Fifth | 3 out |
| Friday, April 25 |
| » Defeated Angels (10-7), 7-4 | Hubert H. Humphrey Metrodome (3-4) | 8-9 | |
| » W: Bert Blyleven (2-0) L: Jim Slaton (2-1) | Fifth | 2 out |
| Saturday, April 26 |
| » Lost to Angels (11-7), 7-6 | Hubert H. Humphrey Metrodome (3-5) | 8-10 | |
| » W: T.R. Bryden (1-0) L: Ron Davis (1-2) S: Donnie Moore (3) | Fifth | 3 out |
| Sunday, April 27 |
| » Lost to Angels (12-7), 8-7 | Hubert H. Humphrey Metrodome (3-6) | 8-11 | Lost 2 |
| » W: T.R. Bryden (2-0) L: Roy Smith (0-2) S: Donnie Moore (4) | Fifth | 4 out |
| Tuesday, April 29 |
| » Lost to Yankees (13-6), 14-11 | Yankee Stadium (0-1) | 8-12 | Lost 3 |
| » W: Ed Whitson (2-1) L: Mark Portugal (0-2) | Fifth | 5 out |
| Wednesday, April 30 |
| » Lost to Yankees (14-6), 3-2 | Yankee Stadium (0-2) | 8-13 | Lost 4 |
| » W: Joe Niekro (3-0) L: Bert Blyleven (2-1) S: Brian Fisher (3) | Fourth | 5 out |
| Thursday, May 1 |
| » Defeated Yankees (14-7), 7-4 | Yankee Stadium (1-2) | 9-13 | |
| » W: Juan Agosto (1-2) L: Dennis Rasmussen (2-1) | Fourth | 5 out |
| Friday, May 2 |
| » Defeated Tigers (10-10), 10-1 | Tiger Stadium (1-0) | 10-13 | Won 2 |
| » W: Mike Smithson (3-2) L: Jack Morris (3-3) | Fourth | 4 out |
| Saturday, May 3 |
| » Lost to Tigers (11-10), 7-4 | Tiger Stadium (1-1) | 10-14 | |
| » W: Walt Terrell (3-1) L: John Butcher (0-3) | Fourth | 4 out |
| Sunday, May 4 |
| » Lost to Tigers (12-10), 4-1 | Tiger Stadium (1-2) | 10-15 | Lost 2 |
| » W: Frank Tanana (4-1) L: Bert Blyleven (2-2) S: Guillermo Hernandez (6) | Fourth | 4 out |
| Tuesday, May 6 |
| » Lost to Orioles (12-12), 5-3 | Hubert H. Humphrey Metrodome (3-7) | 10-16 | Lost 3 |
| » W: Storm Davis (2-1) L: Frank Viola (3-2) S: Don Aase (6) | Fifth | 4½ out |
| Wednesday, May 7 |
| » Defeated Orioles (12-13), 5-2 | Hubert H. Humphrey Metrodome (4-7) | 11-16 | |
| » W: Mike Smithson (4-2) L: Mike Flanagan (1-4) | Fifth | 4½ out |
| Friday, May 9 |
| » Defeated Tigers (13-13), 8-7 | Hubert H. Humphrey Metrodome (5-7) | 12-16 | Won 2 |
| » W: Bert Blyleven (3-2) L: Randy O'Neal (0-2) S: Juan Agosto (1) | Fourth | 3 out |
| Saturday, May 10 |
| » Defeated Tigers (13-14), 12-2 | Hubert H. Humphrey Metrodome (6-7) | 13-16 | Won 3 |
| » W: Frank Viola (4-2) L: Frank Tanana (4-2) | Third | 2 out |
| Sunday, May 11 |
| » Lost to Tigers (14-14), 4-1 | Hubert H. Humphrey Metrodome (6-8) | 13-17 | |
| » W: Dan Petry (3-2) L: Mike Smithson (4-3) | Fourth | 3 out |
| Monday, May 12 |
| » Lost to Yankees (20-11), 9-8 | Hubert H. Humphrey Metrodome (6-9) | 13-18 | Lost 2 |
| » W: Dennis Rasmussen (3-1) L: Mark Portugal (0-3) S: Dave Righetti (9) | Fifth | 4 out |
| Tuesday, May 13 |
| » Lost to Yankees (21-11), 6-4 | Hubert H. Humphrey Metrodome (6-10) | 13-19 | Lost 3 |
| » W: Tommy John (2-0) L: Bert Blyleven (3-3) S: Dave Righetti (10) | Fifth | 5 out |
| Wednesday, May 14 |
| » Lost to Orioles (17-14), 8-3 | Memorial Stadium (0-1) | 13-20 | Lost 4 |
| » W: Ken Dixon (4-2) L: Juan Agosto (1-3) | Fifth | 5 out |
| Thursday, May 15 |
| » Lost to Orioles (18-14), 5-3 | Memorial Stadium (0-2) | 13-21 | Lost 5 |
| » W: Mike Boddicker (4-0) L: Frank Viola (4-3) S: Don Aase (9) | Fifth | 5½ out |
| Friday, May 16 |
| » Lost to Brewers (18-15), 7-6 | County Stadium (0-1) | 13-22 | Lost 6 |
| » W: Mark Clear (2-1) L: Ron Davis (1-3) | Seventh | 6½ out |
| Saturday, May 17 |
| » Lost to Brewers (19-15), 4-1 | County Stadium (0-2) | 13-23 | Lost 7 |
| » W: Teddy Higuera (5-3) L: Mark Portugal (0-4) | Seventh | 6½ out |
| Sunday, May 18 |
| » Defeated Brewers (19-16), 5-3 | County Stadium (1-2) | 14-23 | |
| » W: Bert Blyleven (4-3) L: Tim Leary (3-4) | Sixth | 6 out |
| Monday, May 19 |
| » Lost to Red Sox (24-13), 8-7 | Fenway Park (0-1) | 14-24 | |
| » W: Joe Sambito (1-0) L: Ron Davis (1-4) | Sixth | 6½ out |
| Tuesday, May 20 |
| » Lost to Red Sox (25-13), 17-7 | Fenway Park (0-2) | 14-25 | Lost 2 |
| » W: Roger Clemens (7-0) L: Frank Viola (4-4) | Sixth | 7½ out |
| Wednesday, May 21 |
| » Lost to Red Sox (26-13), 3-2 | Fenway Park (0-3) | 14-26 | Lost 3 |
| » W: Sammy Stewart (3-1) L: Mark Portugal (0-5) S: Bob Stanley (6) | Sixth | 7½ out |
| Friday, May 23 |
| » Defeated Brewers (20-19), 8-7 | Hubert H. Humphrey Metrodome (7-10) | 15-26 | |
| » W: Frank Pastore (1-0) L: Dan Plesac (3-2) | Sixth | 6 out |
| Saturday, May 24 |
| » Lost to Brewers (21-19), 6-3 | Hubert H. Humphrey Metrodome (7-11) | 15-27 | |
| » W: Juan Nieves (4-1) L: Frank Viola (4-5) | Sixth | 6½ out |
| Sunday, May 25 |
| » Defeated Brewers (21-20), 4-3 | Hubert H. Humphrey Metrodome (8-11) | 16-27 | |
| » W: Mike Smithson (5-3) L: Bill Wegman (0-5) | Sixth | 5½ out |
| Monday, May 26 |
| » Defeated Blue Jays (20-25), 9-1 | Hubert H. Humphrey Metrodome (9-11) | 17-27 | Won 2 |
| » W: Mark Portugal (1-5) L: Doyle Alexander (3-2) | Sixth | 5½ out |
| Tuesday, May 27 |
| » Defeated Blue Jays (20-26), 7-6 | Hubert H. Humphrey Metrodome (10-11) | 18-27 | Won 3 |
| » W: Frank Pastore (2-0) L: Tom Henke (3-3) | Sixth | 5½ out |
| Wednesday, May 28 |
| » Lost to Blue Jays (21-26), 14-8 | Hubert H. Humphrey Metrodome (10-12) | 18-28 | |
| » W: Jim Clancy (5-3) L: Bert Blyleven (4-4) | Sixth | 6½ out |
| Friday, May 30 |
| » Defeated Red Sox (31-15), 13-5 | Hubert H. Humphrey Metrodome (11-12) | 19-28 | |
| » W: Keith Atherton (2-2) L: Rob Woodward (0-1) | Fifth | 5½ out |
| Saturday, May 31 |
| » Lost to Red Sox (32-15), 7-2 | Hubert H. Humphrey Metrodome (11-13) | 19-29 | |
| » W: Bruce Hurst (5-3) L: Mike Smithson (5-4) | Fifth | 5½ out |
| Sunday, June 1 |
| » Lost to Red Sox (33-15), 6-3 | Hubert H. Humphrey Metrodome (11-14) | 19-30 | Lost 2 |
| » W: Roger Clemens (9-0) L: Mark Portugal (1-6) | Fifth | 5½ out |
| Monday, June 2 |
| » Lost to Blue Jays (24-27), 3-1 | Exhibition Stadium (0-1) | 19-31 | Lost 3 |
| » W: Jim Clancy (6-3) L: Bert Blyleven (4-5) S: Tom Henke (5) | Sixth | 6½ out |
| Tuesday, June 3 |
| » Lost to Blue Jays (25-27), 6-5 | Exhibition Stadium (0-2) | 19-32 | Lost 4 |
| » W: Mark Eichhorn (5-2) L: Keith Atherton (2-3) S: Tom Henke (6) | Sixth | 7½ out |
| Wednesday, June 4 |
| » Defeated Blue Jays (25-28), 10-4 | Exhibition Stadium (1-2) | 20-32 | |
| » W: Frank Viola (5-5) L: Dave Stieb (1-7) | Fifth | 7½ out |
| Thursday, June 5 |
| » Lost to Royals (27-25), 8-2 | Royals Stadium (0-1) | 20-33 | |
| » W: Scott Bankhead (2-0) L: Mike Smithson (5-5) | Sixth | 8 out |
| Friday, June 6 |
| » Lost to Royals (28-25), 6-1 | Royals Stadium (0-2) | 20-34 | Lost 2 |
| » W: Charlie Leibrandt (6-3) L: Juan Agosto (1-4) | Sixth | 9 out |
| Saturday, June 7 |
| » Defeated Royals (28-26), 4-1 | Royals Stadium (1-2) | 21-34 | |
| » W: Bert Blyleven (5-5) L: Danny Jackson (2-3) | Sixth | 9½ out |
| Sunday, June 8 |
| » Defeated Royals (28-27), 5-2 | Royals Stadium (2-2) | 22-34 | Won 2 |
| » W: Mark Portugal (2-6) L: Bret Saberhagen (3-6) S: Frank Pastore (1) | Sixth | 9½ out |
| » Major-league debuts: David Cone (Royals) |
| Monday, June 9 |
| » Defeated Rangers (31-25), 3-2 | Hubert H. Humphrey Metrodome (12-14) | 23-34 | Won 3 |
| » W: Keith Atherton (3-3) L: Mitch Williams (5-1) | Fifth | 8½ out |
| Tuesday, June 10 |
| » Lost to Rangers (32-25), 14-10 | Hubert H. Humphrey Metrodome (12-15) | 23-35 | |
| » W: Jeff Russell (1-0) L: Ron Davis (1-5) S: Greg Harris (11) | Sixth | 9½ out |
| Wednesday, June 11 |
| » Lost to Rangers (33-25), 6-2 | Hubert H. Humphrey Metrodome (12-16) | 23-36 | Lost 2 |
| » W: Mitch Williams (6-1) L: Roy Lee Jackson (0-1) | Fifth | 10½ out |
| » Major-league debuts: Allan Anderson (Twins) |
| Friday, June 13 |
| » Lost to Indians (30-28), 11-2 | Cleveland Stadium (0-1) | 23-37 | Lost 3 |
| » W: Tom Candiotti (4-6) L: Bert Blyleven (5-6) | Fifth | 11½ out |
| » Major-league debuts: Cory Snyder (Indians) |
| Saturday, June 14 |
| » Defeated Indians (30-29), 9-3 | Cleveland Stadium (1-1) | 24-37 | |
| » W: Keith Atherton (4-3) L: Neal Heaton (3-6) | Sixth | 10½ out |
| Sunday, June 15 |
| » Defeated Indians (30-30), 7-3 | Cleveland Stadium (2-1) | 25-37 | Won 2 |
| » W: Frank Viola (6-5) L: Don Schulze (3-4) S: Frank Pastore (2) | Fifth | 9½ out |
| Tuesday, June 17 |
| » Defeated White Sox (25-37), 4-1 | Hubert H. Humphrey Metrodome (13-16) | 26-37 | Won 3 |
| » W: Mike Smithson (6-5) L: Richard Dotson (4-7) S: Keith Atherton (1) | Fourth | 8 out |
| Wednesday, June 18 |
| » Defeated White Sox (25-38), 10-9 | Hubert H. Humphrey Metrodome (14-16) | 27-37 | Won 4 |
| » W: Ron Davis (2-5) L: Gene Nelson (4-3) | Fifth | 7 out |
| Thursday, June 19 |
| » Lost to White Sox (26-38), 9-8 | Hubert H. Humphrey Metrodome (14-17) | 27-38 | |
| » W: Floyd Bannister (3-4) L: Allan Anderson (0-1) S: Bob James (9) | Fifth | 8 out |
| Friday, June 20 |
| » Defeated Indians (32-32), 9-8 | Hubert H. Humphrey Metrodome (15-17) | 28-38 | |
| » W: Frank Viola (7-5) L: Dickie Noles (0-1) S: Keith Atherton (2) | Fourth | 8 out |
| » Major-league debuts: Mark Davidson (Twins) |
| Saturday, June 21 |
| » Lost to Indians (33-32), 7-5 | Hubert H. Humphrey Metrodome (15-18) | 28-39 | |
| » W: Don Schulze (4-4) L: Mark Portugal (2-7) S: Ernie Camacho (8) | Fourth | 9 out |
| Sunday, June 22 |
| » Lost to Indians (34-32), 4-1 | Hubert H. Humphrey Metrodome (15-19) | 28-40 | Lost 2 |
| » W: Phil Niekro (4-6) L: Mike Smithson (6-6) | Fifth | 10 out |
| Monday, June 23 |
| » Lost to White Sox (29-39), 11-2 | Comiskey Park I (0-1) | 28-41 | Lost 3 |
| » W: Joe Cowley (4-3) L: Bert Blyleven (5-7) | Fifth | 10 out |
| Tuesday, June 24 |
| » Defeated White Sox (29-40), 2-1 | Comiskey Park I (1-1) | 29-41 | |
| » W: Allan Anderson (1-1) L: Joel Davis (3-4) | Fourth | 9 out |
| Wednesday, June 25 |
| » Lost to White Sox (30-40), 4-3 | Comiskey Park I (1-2) | 29-42 | |
| » W: Joel McKeon (3-1) L: Frank Viola (7-6) S: Bob James (10) | Fifth | 10 out |
| Friday, June 27 |
| » Defeated Royals (37-36), 6-4 | Hubert H. Humphrey Metrodome (16-19) | 30-42 | |
| » W: Mike Smithson (7-6) L: Scott Bankhead (3-1) S: Keith Atherton (3) | Fifth | 9 out |
| Saturday, June 28 |
| » Defeated Royals (37-37), 7-2 | Hubert H. Humphrey Metrodome (17-19) | 31-42 | Won 2 |
| » W: Bert Blyleven (6-7) L: Danny Jackson (4-5) S: Neal Heaton (1) | Fifth | 9 out |
| Sunday, June 29 |
| » Defeated Royals (37-38), 9-4 | Hubert H. Humphrey Metrodome (18-19) | 32-42 | Won 3 |
| » W: Allan Anderson (2-1) L: Bret Saberhagen (4-9) S: Keith Atherton (4) | Fifth | 8 out |
| Monday, June 30 |
| » Defeated Rangers (40-36), 5-2 | Arlington Stadium (1-0) | 33-42 | Won 4 |
| » W: Frank Viola (8-6) L: Greg Harris (3-7) S: Keith Atherton (5) | Fifth | 7 out |
| Tuesday, July 1 |
| » Lost to Rangers (41-36), 5-0 | Arlington Stadium (1-1) | 33-43 | |
| » W: Charlie Hough (8-3) L: Mark Portugal (2-8) | Fifth | 7½ out |
| Wednesday, July 2 |
| » Lost to Rangers (42-36), 10-2 | Arlington Stadium (1-2) | 33-44 | Lost 2 |
| » W: Mike Mason (5-2) L: Mike Smithson (7-7) | Fifth | 8½ out |
| Thursday, July 3 |
| » Defeated Orioles (40-37), 11-7 | Hubert H. Humphrey Metrodome (19-19) | 34-44 | |
| » W: Bert Blyleven (7-7) L: Mike Boddicker (10-4) | Fifth | 8 out |
| Friday, July 4 |
| » Lost to Orioles (41-37), 12-7 | Hubert H. Humphrey Metrodome (19-20) | 34-45 | |
| » W: Brad Havens (3-1) L: Frank Pastore (2-1) S: Don Aase (21) | Fifth | 9 out |
| Saturday, July 5 |
| » Defeated Orioles (41-38), 7-6 | Hubert H. Humphrey Metrodome (20-20) | 35-45 | |
| » W: Frank Viola (9-6) L: Mike Flanagan (2-6) | Fifth | 9 out |
| Sunday, July 6 |
| » Lost to Orioles (42-38), 1-0 | Hubert H. Humphrey Metrodome (20-21) | 35-46 | |
| » W: Ken Dixon (7-7) L: Neal Heaton (3-7) S: Don Aase (22) | Fifth | 9 out |
| Monday, July 7 |
| » Defeated Tigers (39-42), 10-8 | Hubert H. Humphrey Metrodome (21-21) | 36-46 | |
| » W: Mike Smithson (8-7) L: Randy O'Neal (1-4) S: Keith Atherton (6) | Fifth | 8½ out |
| Tuesday, July 8 |
| » Lost to Tigers (40-42), 5-1 | Hubert H. Humphrey Metrodome (21-22) | 36-47 | |
| » W: Eric King (5-1) L: Bert Blyleven (7-8) S: Guillermo Hernandez (18) | Fifth | 9½ out |
| Wednesday, July 9 |
| » Lost to Tigers (41-42), 7-0 | Hubert H. Humphrey Metrodome (21-23) | 36-48 | Lost 2 |
| » W: Jack Morris (8-6) L: Allan Anderson (2-2) | Fifth | 10½ out |
| Thursday, July 10 |
| » Lost to Yankees (48-38), 11-1 | Hubert H. Humphrey Metrodome (21-24) | 36-49 | Lost 3 |
| » W: Dennis Rasmussen (10-2) L: Frank Viola (9-7) | Sixth | 10½ out |
| Friday, July 11 |
| » Lost to Yankees (49-38), 9-3 | Hubert H. Humphrey Metrodome (21-25) | 36-50 | Lost 4 |
| » W: Doug Drabek (1-2) L: Neal Heaton (3-8) S: Brian Fisher (4) | Sixth | 11½ out |
| Saturday, July 12 |
| » Lost to Yankees (50-38), 8-0 | Hubert H. Humphrey Metrodome (21-26) | 36-51 | Lost 5 |
| » W: Scott Nielsen (2-0) L: Mike Smithson (8-8) | Sixth | 11½ out |
| Sunday, July 13 |
| » Defeated Yankees (50-39), 5-0 | Hubert H. Humphrey Metrodome (22-26) | 37-51 | |
| » W: Bert Blyleven (8-8) L: Bob Tewksbury (6-4) | Sixth | 11½ out |
| Thursday, July 17 |
| » Lost to Orioles (47-41), 6-2 | Memorial Stadium (0-3) | 37-52 | |
| » W: Ken Dixon (9-7) L: Frank Viola (9-8) S: Don Aase (24) | Sixth | 11½ out |
| Friday, July 18 |
| » Defeated Orioles (47-42), 7-3 | Memorial Stadium (1-3) | 38-52 | |
| » W: Bert Blyleven (9-8) L: Scott McGregor (6-9) S: Keith Atherton (7) | Sixth | 10½ out |
| Saturday, July 19 |
| » Lost to Orioles (48-42), 1-0 | Memorial Stadium (1-4) | 38-53 | |
| » W: Mike Flanagan (4-6) L: Neal Heaton (3-9) S: Don Aase (25) | Sixth | 11½ out |
| Sunday, July 20 |
| » Lost to Orioles (49-42), 8-3 | Memorial Stadium (1-5) | 38-54 | Lost 2 |
| » W: Mike Boddicker (12-5) L: Mike Smithson (8-9) | Sixth | 11½ out |
| Monday, July 21 |
| » Defeated Tigers (47-45), 1-0 | Tiger Stadium (2-2) | 39-54 | |
| » W: Frank Viola (10-8) L: Mark Thurmond (3-8) S: Keith Atherton (8) | Sixth | 10½ out |
| Tuesday, July 22 |
| » Lost to Tigers (48-45), 3-0 | Tiger Stadium (2-3) | 39-55 | |
| » W: Walt Terrell (9-8) L: Bert Blyleven (9-9) S: Guillermo Hernandez (19) | Sixth | 10½ out |
| Wednesday, July 23 |
| » Lost to Tigers (49-45), 12-2 | Tiger Stadium (2-4) | 39-56 | Lost 2 |
| » W: Jack Morris (11-6) L: Allan Anderson (2-3) | Seventh | 11½ out |
| Friday, July 25 |
| » Defeated Yankees (55-42), 9-5 | Yankee Stadium (2-2) | 40-56 | |
| » W: Neal Heaton (4-9) L: Scott Nielsen (2-2) S: Keith Atherton (9) | Seventh | 10½ out |
| Saturday, July 26 |
| » Defeated Yankees (55-43), 8-4 | Yankee Stadium (3-2) | 41-56 | Won 2 |
| » W: Allan Anderson (3-3) L: Doug Drabek (2-3) | Seventh | 10½ out |
| Sunday, July 27 |
| » Lost to Yankees (56-43), 4-1 | Yankee Stadium (3-3) | 41-57 | |
| » W: Ron Guidry (5-8) L: Bert Blyleven (9-10) S: Dave Righetti (23) | Seventh | 11½ out |
| Monday, July 28 |
| » Defeated Mariners (44-57), 6-5 | Hubert H. Humphrey Metrodome (23-26) | 42-57 | |
| » W: Keith Atherton (5-3) L: Karl Best (1-2) | Seventh | 11½ out |
| Tuesday, July 29 |
| » Defeated Mariners (44-58), 4-2 | Hubert H. Humphrey Metrodome (24-26) | 43-57 | Won 2 |
| » W: Frank Viola (11-8) L: Jim Beattie (0-5) S: Roy Lee Jackson (1) | Sixth | 10½ out |
| Wednesday, July 30 |
| » Lost to Mariners (45-58), 4-2 | Hubert H. Humphrey Metrodome (24-27) | 43-58 | |
| » W: Mike Morgan (8-10) L: Neal Heaton (4-10) S: Matt Young (10) | Seventh | 11½ out |
| Friday, August 1 |
| » Defeated Athletics (44-61), 10-1 | Hubert H. Humphrey Metrodome (25-27) | 44-58 | |
| » W: Bert Blyleven (10-10) L: Curt Young (7-7) | Sixth | 12 out |
| » Major-league debuts: Darrel Akerfelds (Athletics) |
| Saturday, August 2 |
| » Defeated Athletics (44-62), 8-0 | Hubert H. Humphrey Metrodome (26-27) | 45-58 | Won 2 |
| » W: Mike Smithson (9-9) L: Joaquin Andujar (6-4) | Sixth | 11 out |
| Sunday, August 3 |
| » Lost to Athletics (45-62), 5-4 | Hubert H. Humphrey Metrodome (26-28) | 45-59 | |
| » W: Doug Bair (2-2) L: Keith Atherton (5-4) S: Jay Howell (7) | Sixth | 11 out |
| Monday, August 4 |
| » Defeated Angels (56-49), 6-5 | Hubert H. Humphrey Metrodome (27-28) | 46-59 | |
| » W: Frank Pastore (3-1) L: Donnie Moore (1-4) | Sixth | 10 out |
| Tuesday, August 5 |
| » Lost to Angels (57-49), 13-1 | Hubert H. Humphrey Metrodome (27-29) | 46-60 | |
| » W: Mike Witt (12-7) L: Allan Anderson (3-4) | Sixth | 11 out |
| Wednesday, August 6 |
| » Defeated Angels (57-50), 5-2 | Hubert H. Humphrey Metrodome (28-29) | 47-60 | |
| » W: Bert Blyleven (11-10) L: Don Sutton (10-8) | Sixth | 10 out |
| Friday, August 8 |
| » Lost to Athletics (48-63), 5-2 | Oakland-Alameda County Stadium (2-2) | 47-61 | |
| » W: Joaquin Andujar (7-4) L: Mike Smithson (9-10) S: Doug Bair (4) | Fifth | 11½ out |
| Saturday, August 9 |
| » Defeated Athletics (48-64), 9-2 | Oakland-Alameda County Stadium (3-2) | 48-61 | |
| » W: Frank Viola (12-8) L: Dave Stewart (4-1) | Fourth | 11½ out |
| Sunday, August 10 |
| » Lost to Athletics (49-64), 6-2 | Oakland-Alameda County Stadium (3-3) | 48-62 | |
| » W: Curt Young (9-7) L: Neal Heaton (4-11) S: Jay Howell (8) | Sixth | 13 out |
| » Lost to Athletics (50-64), 6-5 | Oakland-Alameda County Stadium (3-4) | 48-63 | Lost 2 |
| » W: Jose Rijo (5-8) L: Keith Atherton (5-5) S: Jay Howell (9) | Sixth | 13 out |
| Monday, August 11 |
| » Defeated Angels (61-51), 2-0 | Anaheim Stadium (2-3) | 49-63 | |
| » W: Bert Blyleven (12-10) L: Don Sutton (10-9) | Fifth | 12 out |
| Tuesday, August 12 |
| » Lost to Angels (62-51), 5-4 | Anaheim Stadium (2-4) | 49-64 | |
| » W: Gary Lucas (1-0) L: Ron Davis (2-6) | Sixth | 13 out |
| Wednesday, August 13 |
| » Defeated Angels (62-52), 6-2 | Anaheim Stadium (3-4) | 50-64 | |
| » W: Frank Viola (13-8) L: Vern Ruhle (1-1) | Sixth | 12 out |
| Thursday, August 14 |
| » Defeated Mariners (49-68), 14-1 | Kingdome (3-1) | 51-64 | Won 2 |
| » W: Mark Portugal (3-8) L: Mark Langston (9-10) | Fifth | 11½ out |
| Friday, August 15 |
| » Lost to Mariners (50-68), 1-0 | Kingdome (3-2) | 51-65 | |
| » W: Mike Moore (7-10) L: Keith Atherton (5-6) | Fifth | 12½ out |
| Saturday, August 16 |
| » Lost to Mariners (51-68), 7-6 | Kingdome (3-3) | 51-66 | Lost 2 |
| » W: Pete Ladd (8-4) L: Keith Atherton (5-7) | Sixth | 13½ out |
| Sunday, August 17 |
| » Lost to Mariners (52-68), 11-1 | Kingdome (3-4) | 51-67 | Lost 3 |
| » W: Mike Morgan (9-12) L: Mike Smithson (9-11) | Sixth | 14½ out |
| Monday, August 18 |
| » Lost to Red Sox (70-48), 3-1 | Hubert H. Humphrey Metrodome (28-30) | 51-68 | Lost 4 |
| » W: Tom Seaver (7-10) L: Frank Viola (13-9) S: Bob Stanley (15) | Sixth | 15 out |
| Tuesday, August 19 |
| » Defeated Red Sox (70-49), 5-1 | Hubert H. Humphrey Metrodome (29-30) | 52-68 | |
| » W: Mark Portugal (4-8) L: Al Nipper (8-8) S: George Frazier (1) | Sixth | 14½ out |
| Wednesday, August 20 |
| » Lost to Red Sox (71-49), 9-1 | Hubert H. Humphrey Metrodome (29-31) | 52-69 | |
| » W: Roger Clemens (19-4) L: Neal Heaton (4-12) | Seventh | 14½ out |
| Friday, August 22 |
| » Defeated Blue Jays (65-58), 4-3 | Hubert H. Humphrey Metrodome (30-31) | 53-69 | |
| » W: Bert Blyleven (13-10) L: Jim Clancy (13-7) S: George Frazier (2) | Fifth | 14 out |
| Saturday, August 23 |
| » Lost to Blue Jays (66-58), 7-4 | Hubert H. Humphrey Metrodome (30-32) | 53-70 | |
| » W: John Cerutti (7-3) L: Mike Smithson (9-12) S: Mark Eichhorn (7) | Sixth | 14 out |
| Sunday, August 24 |
| » Lost to Blue Jays (67-58), 7-5 | Hubert H. Humphrey Metrodome (30-33) | 53-71 | Lost 2 |
| » W: Tom Henke (8-3) L: Keith Atherton (5-8) | Seventh | 15 out |
| Tuesday, August 26 |
| » Lost to Brewers (63-61), 6-5 | County Stadium (1-3) | 53-72 | Lost 3 |
| » W: Mark Clear (5-4) L: Keith Atherton (5-9) | Seventh | 16½ out |
| Wednesday, August 27 |
| » Defeated Brewers (63-62), 7-5 | County Stadium (2-3) | 54-72 | |
| » W: Neal Heaton (5-12) L: Juan Nieves (10-7) S: George Frazier (3) | Seventh | 16 out |
| Thursday, August 28 |
| » Defeated Brewers (63-63), 6-2 | County Stadium (3-3) | 55-72 | Won 2 |
| » W: Bert Blyleven (14-10) L: Chris Bosio (0-3) | Seventh | 16 out |
| Friday, August 29 |
| » Lost to Blue Jays (71-58), 6-5 | Exhibition Stadium (1-3) | 55-73 | |
| » W: Mark Eichhorn (12-4) L: Keith Atherton (5-10) | Seventh | 17 out |
| Saturday, August 30 |
| » Lost to Blue Jays (72-58), 8-1 | Exhibition Stadium (1-4) | 55-74 | Lost 2 |
| » W: Joe Johnson (10-8) L: Frank Viola (13-10) S: Dennis Lamp (2) | Seventh | 18 out |
| Sunday, August 31 |
| » Lost to Blue Jays (73-58), 7-5 | Exhibition Stadium (1-5) | 55-75 | Lost 3 |
| » W: Luis Aquino (1-1) L: Allan Anderson (3-5) S: Mark Eichhorn (8) | Seventh | 19 out |
| Monday, September 1 |
| » Defeated Brewers (64-66), 9-3 | Hubert H. Humphrey Metrodome (31-33) | 56-75 | |
| » W: Neal Heaton (6-12) L: Juan Nieves (10-8) S: George Frazier (4) | Seventh | 18 out |
| Tuesday, September 2 |
| » Defeated Brewers (64-67), 4-0 | Hubert H. Humphrey Metrodome (32-33) | 57-75 | Won 2 |
| » W: Bert Blyleven (15-10) L: Pete Vuckovich (0-1) | Seventh | 18 out |
| Wednesday, September 3 |
| » Defeated Brewers (64-68), 11-5 | Hubert H. Humphrey Metrodome (33-33) | 58-75 | Won 3 |
| » W: Mike Smithson (10-12) L: Teddy Higuera (17-9) | Seventh | 18 out |
| Friday, September 5 |
| » Lost to Red Sox (80-54), 12-2 | Fenway Park (0-4) | 58-76 | |
| » W: Roger Clemens (21-4) L: Frank Viola (13-11) | Seventh | 18 out |
| Saturday, September 6 |
| » Lost to Red Sox (81-54), 3-2 | Fenway Park (0-5) | 58-77 | Lost 2 |
| » W: Oil Can Boyd (14-9) L: George Frazier (2-5) | Seventh | 19 out |
| Sunday, September 7 |
| » Lost to Red Sox (82-54), 9-0 | Fenway Park (0-6) | 58-78 | Lost 3 |
| » W: Bruce Hurst (10-7) L: Neal Heaton (6-13) | Seventh | 20 out |
| Monday, September 8 |
| » Lost to Royals (64-74), 5-0 | Royals Stadium (2-3) | 58-79 | Lost 4 |
| » W: Dennis Leonard (7-11) L: Bert Blyleven (15-11) | Seventh | 20½ out |
| Tuesday, September 9 |
| » Lost to Royals (65-74), 11-3 | Royals Stadium (2-4) | 58-80 | Lost 5 |
| » W: Mark Gubicza (9-6) L: Mike Smithson (10-13) S: Steve Farr (8) | Sixth | 21½ out |
| Thursday, September 11 |
| » Defeated Rangers (72-68), 6-2 | Hubert H. Humphrey Metrodome (34-33) | 59-80 | |
| » W: Frank Viola (14-11) L: Charlie Hough (12-10) | Seventh | 21½ out |
| Friday, September 12 |
| » Defeated Rangers (72-69), 4-2 | Hubert H. Humphrey Metrodome (35-33) | 60-80 | Won 2 |
| » Manager: Tom Kelly |
| » W: Neal Heaton (7-13) L: Ed Correa (9-13) S: Keith Atherton (10) | Seventh | 20½ out |
| Saturday, September 13 |
| » Lost to Rangers (73-69), 14-1 | Hubert H. Humphrey Metrodome (35-34) | 60-81 | |
| » W: Mike Mason (7-3) L: Bert Blyleven (15-12) | Seventh | 21½ out |
| Sunday, September 14 |
| » Defeated Rangers (73-70), 7-6 | Hubert H. Humphrey Metrodome (36-34) | 61-81 | |
| » W: George Frazier (3-5) L: Dale Mohorcic (2-3) | Seventh | 20½ out |
| Monday, September 15 |
| » Lost to Indians (73-71), 4-0 | Cleveland Stadium (2-2) | 61-82 | |
| » W: Tom Candiotti (14-11) L: Frank Viola (14-12) | Seventh | 21½ out |
| Tuesday, September 16 |
| » Defeated Indians (73-72), 7-3 | Cleveland Stadium (3-2) | 62-82 | |
| » W: Mark Portugal (5-8) L: Scott Bailes (10-9) | Seventh | 21½ out |
| Wednesday, September 17 |
| » Lost to Indians (74-72), 5-2 | Cleveland Stadium (3-3) | 62-83 | |
| » W: Greg Swindell (3-1) L: Mike Smithson (10-14) S: Frank Wills (4) | Seventh | 22½ out |
| Friday, September 19 |
| » Lost to Rangers (77-70), 4-1 | Arlington Stadium (1-3) | 62-84 | Lost 2 |
| » W: Charlie Hough (14-10) L: Bert Blyleven (15-13) | Seventh | 23 out |
| Saturday, September 20 |
| » Defeated Rangers (77-71), 3-2 | Arlington Stadium (2-3) | 63-84 | |
| » W: Frank Viola (15-12) L: Mitch Williams (8-5) S: George Frazier (5) | Seventh | 23 out |
| Sunday, September 21 |
| » Lost to Rangers (78-71), 2-1 | Arlington Stadium (2-4) | 63-85 | |
| » W: Bobby Witt (9-9) L: Mark Portugal (5-9) S: Greg Harris (18) | Seventh | 24 out |
| Monday, September 22 |
| » Defeated Royals (69-81), 2-1 | Hubert H. Humphrey Metrodome (37-34) | 64-85 | |
| » W: Keith Atherton (6-10) L: Danny Jackson (10-11) | Seventh | 23½ out |
| Tuesday, September 23 |
| » Defeated Royals (69-82), 9-2 | Hubert H. Humphrey Metrodome (38-34) | 65-85 | Won 2 |
| » W: Mike Smithson (11-14) L: Dennis Leonard (8-13) | Seventh | 22½ out |
| Wednesday, September 24 |
| » Lost to Royals (70-82), 2-1 | Hubert H. Humphrey Metrodome (38-35) | 65-86 | |
| » W: Dan Quisenberry (3-7) L: Bert Blyleven (15-14) |