| Monday, April 7 |
| » Lost to Indians (1-0), 6-4 | Memorial Stadium (0-1) | 0-1 | |
| » W: Ken Schrom (1-0) L: Mike Flanagan (0-1) S: Ernie Camacho (1) | Third | 1 out |
| » Major-league debuts: Andy Allanson (Indians) |
| Wednesday, April 9 |
| » Defeated Indians (1-1), 4-3 | Memorial Stadium (1-1) | 1-1 | |
| » W: Don Aase (1-0) L: Scott Bailes (0-1) | Second | 1 out |
| » Major-league debuts: Scott Bailes (Indians) |
| Thursday, April 10 |
| » Defeated Indians (1-2), 5-1 | Memorial Stadium (2-1) | 2-1 | Won 2 |
| » W: Ken Dixon (1-0) L: Jim Kern (0-1) S: Rich Bordi (1) | Second | 1 out |
| Friday, April 11 |
| » Lost to Rangers (2-2), 5-4 | Arlington Stadium (0-1) | 2-2 | |
| » W: Ricky Wright (1-0) L: Don Aase (1-1) | Second | 1 out |
| Saturday, April 12 |
| » Lost to Rangers (3-2), 2-1 | Arlington Stadium (0-2) | 2-3 | Lost 2 |
| » W: Greg Harris (1-1) L: Brad Havens (0-1) | Third | 2 out |
| Sunday, April 13 |
| » Defeated Rangers (3-3), 3-2 | Arlington Stadium (1-2) | 3-3 | |
| » W: Scott McGregor (1-0) L: Jose Guzman (1-1) S: Don Aase (1) | Second | 2 out |
| Monday, April 14 |
| » Defeated Blue Jays (3-4), 2-1 | Exhibition Stadium (1-0) | 4-3 | Won 2 |
| » W: Mike Boddicker (1-0) L: Doyle Alexander (1-1) | Second | 1½ out |
| Thursday, April 17 |
| » Defeated Blue Jays (3-5), 5-3 | Exhibition Stadium (2-0) | 5-3 | Won 3 |
| » W: Mike Flanagan (1-1) L: Jimmy Key (0-1) S: Don Aase (2) | Second | 1½ out |
| » Lost to Blue Jays (4-5), 7-4 | Exhibition Stadium (2-1) | 5-4 | |
| » W: Tom Henke (2-0) L: Tippy Martinez (0-1) | Second | 1½ out |
| Friday, April 18 |
| » Lost to Rangers (6-3), 12-3 | Memorial Stadium (2-2) | 5-5 | Lost 2 |
| » W: Mike Mason (1-0) L: Scott McGregor (1-1) | Third | 1½ out |
| Saturday, April 19 |
| » Defeated Rangers (6-4), 10-4 | Memorial Stadium (3-2) | 6-5 | |
| » W: Mike Boddicker (2-0) L: Mickey Mahler (0-1) S: Don Aase (3) | Second | ½ out |
| Sunday, April 20 |
| » Defeated Rangers (6-5), 6-1 | Memorial Stadium (4-2) | 7-5 | Won 2 |
| » W: Storm Davis (1-0) L: Jose Guzman (1-2) | Second | ½ out |
| Monday, April 21 |
| » Lost to Indians (6-5), 7-0 | Cleveland Stadium (0-1) | 7-6 | |
| » W: Tom Candiotti (1-1) L: Mike Flanagan (1-2) | Fourth | 1½ out |
| Tuesday, April 22 |
| » Defeated Indians (6-6), 5-2 | Cleveland Stadium (1-1) | 8-6 | |
| » W: Ken Dixon (2-0) L: Phil Niekro (1-2) S: Don Aase (4) | Second | 1½ out |
| Wednesday, April 23 |
| » Lost to Indians (7-6), 5-1 | Cleveland Stadium (1-2) | 8-7 | |
| » W: Ken Schrom (3-1) L: Scott McGregor (1-2) S: Scott Bailes (2) | Fourth | 2½ out |
| Friday, April 25 |
| » Lost to Blue Jays (7-9), 2-1 | Memorial Stadium (4-3) | 8-8 | Lost 2 |
| » W: Mark Eichhorn (2-0) L: Don Aase (1-2) | Third | 4 out |
| Saturday, April 26 |
| » Defeated Blue Jays (7-10), 11-5 | Memorial Stadium (5-3) | 9-8 | |
| » W: Brad Havens (1-1) L: Tom Henke (2-1) | Second | 3 out |
| Sunday, April 27 |
| » Lost to Blue Jays (8-10), 8-0 | Memorial Stadium (5-4) | 9-9 | |
| » W: Jim Clancy (2-1) L: Ken Dixon (2-1) | Third | 3 out |
| Tuesday, April 29 |
| » Defeated White Sox (6-12), 8-1 | Comiskey Park I (1-0) | 10-9 | |
| » W: Scott McGregor (2-2) L: Gene Nelson (1-1) | Third | 3 out |
| Wednesday, April 30 |
| » Lost to White Sox (7-12), 8-6 | Comiskey Park I (1-1) | 10-10 | |
| » W: Richard Dotson (1-2) L: Storm Davis (1-1) S: Bob James (4) | Fifth | 4 out |
| Friday, May 2 |
| » Lost to Royals (10-10), 5-0 | Royals Stadium (0-1) | 10-11 | Lost 2 |
| » W: Bret Saberhagen (2-2) L: Mike Flanagan (1-3) | Fifth | 3½ out |
| Saturday, May 3 |
| » Defeated Royals (10-11), 3-2 | Royals Stadium (1-1) | 11-11 | |
| » W: Ken Dixon (3-1) L: Mark Gubicza (0-4) S: Don Aase (5) | Fifth | 3½ out |
| Sunday, May 4 |
| » Lost to Royals (11-11), 11-1 | Royals Stadium (1-2) | 11-12 | |
| » W: Dennis Leonard (3-2) L: Scott McGregor (2-3) | Fifth | 3½ out |
| Tuesday, May 6 |
| » Defeated Twins (10-16), 5-3 | Hubert H. Humphrey Metrodome (1-0) | 12-12 | |
| » W: Storm Davis (2-1) L: Frank Viola (3-2) S: Don Aase (6) | Sixth | 4 out |
| Wednesday, May 7 |
| » Lost to Twins (11-16), 5-2 | Hubert H. Humphrey Metrodome (1-1) | 12-13 | |
| » W: Mike Smithson (4-2) L: Mike Flanagan (1-4) | Sixth | 5 out |
| Friday, May 9 |
| » Lost to Royals (12-14), 7-4 | Memorial Stadium (5-5) | 12-14 | Lost 2 |
| » W: Buddy Black (2-3) L: Ken Dixon (3-2) S: Steve Farr (2) | Sixth | 5½ out |
| Saturday, May 10 |
| » Defeated Royals (12-15), 5-2 | Memorial Stadium (6-5) | 13-14 | |
| » W: Mike Boddicker (3-0) L: Dennis Leonard (3-3) S: Don Aase (7) | Fifth | 5½ out |
| Sunday, May 11 |
| » Defeated Royals (12-16), 4-3 | Memorial Stadium (7-5) | 14-14 | Won 2 |
| » W: Storm Davis (3-1) L: Charlie Leibrandt (4-1) S: Don Aase (8) | Fifth | 5 out |
| Monday, May 12 |
| » Defeated White Sox (10-19), 4-3 | Memorial Stadium (8-5) | 15-14 | Won 3 |
| » W: Rich Bordi (1-0) L: Bob James (1-3) | Fourth | 4 out |
| Tuesday, May 13 |
| » Defeated White Sox (10-20), 3-1 | Memorial Stadium (9-5) | 16-14 | Won 4 |
| » W: Don Aase (2-2) L: Floyd Bannister (1-4) | Fourth | 4 out |
| Wednesday, May 14 |
| » Defeated Twins (13-20), 8-3 | Memorial Stadium (10-5) | 17-14 | Won 5 |
| » W: Ken Dixon (4-2) L: Juan Agosto (1-3) | Third | 3 out |
| Thursday, May 15 |
| » Defeated Twins (13-21), 5-3 | Memorial Stadium (11-5) | 18-14 | Won 6 |
| » W: Mike Boddicker (4-0) L: Frank Viola (4-3) S: Don Aase (9) | Third | 2½ out |
| Friday, May 16 |
| » Lost to Athletics (19-17), 8-4 | Memorial Stadium (11-6) | 18-15 | |
| » W: Moose Haas (7-1) L: Storm Davis (3-2) | Third | 2½ out |
| Saturday, May 17 |
| » Defeated Athletics (19-18), 8-2 | Memorial Stadium (12-6) | 19-15 | |
| » W: Scott McGregor (3-3) L: Rick Langford (1-4) | Third | 2½ out |
| Sunday, May 18 |
| » Defeated Athletics (19-19), 13-4 | Memorial Stadium (13-6) | 20-15 | Won 2 |
| » W: Rich Bordi (2-0) L: Chris Codiroli (3-4) | Third | 2½ out |
| Tuesday, May 20 |
| » Lost to Angels (21-17), 6-4 | Memorial Stadium (13-7) | 20-16 | |
| » W: Kirk McCaskill (3-3) L: Mike Boddicker (4-1) S: Donnie Moore (7) | Third | 4 out |
| Wednesday, May 21 |
| » Defeated Angels (21-18), 2-1 | Memorial Stadium (14-7) | 21-16 | |
| » W: Storm Davis (4-2) L: Mike Witt (3-4) S: Don Aase (10) | Third | 4 out |
| Thursday, May 22 |
| » Defeated Angels (21-19), 6-3 | Memorial Stadium (15-7) | 22-16 | Won 2 |
| » W: Scott McGregor (4-3) L: Jim Slaton (4-3) S: Rich Bordi (2) | Third | 3½ out |
| Friday, May 23 |
| » Defeated Mariners (15-27), 7-5 | Kingdome (1-0) | 23-16 | Won 3 |
| » W: Ken Dixon (5-2) L: Mike Morgan (3-5) S: Don Aase (11) | Third | 3½ out |
| Saturday, May 24 |
| » Defeated Mariners (15-28), 5-4 | Kingdome (2-0) | 24-16 | Won 4 |
| » W: Nate Snell (1-0) L: Mark Huismann (0-2) | Third | 2½ out |
| Sunday, May 25 |
| » Defeated Mariners (15-29), 6-3 | Kingdome (3-0) | 25-16 | Won 5 |
| » W: Mike Boddicker (5-1) L: Mike Moore (2-6) | Third | 2½ out |
| Monday, May 26 |
| » Lost to Mariners (16-29), 7-6 | Kingdome (3-1) | 25-17 | |
| » W: Mark Langston (3-4) L: Storm Davis (4-3) S: Matt Young (1) | Third | 3½ out |
| Wednesday, May 28 |
| » Defeated Athletics (21-25), 9-5 | Oakland-Alameda County Stadium (1-0) | 26-17 | |
| » W: Rich Bordi (3-0) L: Steve Ontiveros (0-2) | Third | 4 out |
| Thursday, May 29 |
| » Defeated Athletics (21-26), 8-6 | Oakland-Alameda County Stadium (2-0) | 27-17 | Won 2 |
| » W: Brad Havens (2-1) L: Chris Codiroli (3-6) S: Don Aase (12) | Third | 3½ out |
| Friday, May 30 |
| » Defeated Angels (22-25), 3-0 | Anaheim Stadium (1-0) | 28-17 | Won 3 |
| » W: Nate Snell (2-0) L: Ron Romanick (3-2) S: Don Aase (13) | Third | 2½ out |
| Saturday, May 31 |
| » Lost to Angels (23-25), 2-0 | Anaheim Stadium (1-1) | 28-18 | |
| » W: Kirk McCaskill (4-3) L: Storm Davis (4-4) | Third | 3½ out |
| Sunday, June 1 |
| » Lost to Angels (24-25), 7-4 | Anaheim Stadium (1-2) | 28-19 | Lost 2 |
| » W: Mike Witt (5-4) L: Scott McGregor (4-4) S: Doug Corbett (5) | Third | 4½ out |
| Tuesday, June 3 |
| » Defeated Mariners (19-32), 4-2 | Memorial Stadium (16-7) | 29-19 | |
| » W: Mike Boddicker (6-1) L: Milt Wilcox (0-7) S: Don Aase (14) | Third | 5 out |
| Wednesday, June 4 |
| » Lost to Mariners (20-32), 5-1 | Memorial Stadium (16-8) | 29-20 | |
| » W: Mike Moore (3-6) L: Ken Dixon (5-3) | Third | 6 out |
| Thursday, June 5 |
| » Defeated Mariners (20-33), 7-1 | Memorial Stadium (17-8) | 30-20 | |
| » W: Storm Davis (5-4) L: Mark Langston (4-5) | Third | 5 out |
| Friday, June 6 |
| » Defeated Yankees (32-21), 5-2 | Yankee Stadium (1-0) | 31-20 | Won 2 |
| » W: Scott McGregor (5-4) L: Ron Guidry (4-5) S: Don Aase (15) | Second | 5 out |
| Saturday, June 7 |
| » Defeated Yankees (32-22), 7-5 | Yankee Stadium (2-0) | 32-20 | Won 3 |
| » W: Mike Boddicker (7-1) L: Tommy John (3-1) S: Don Aase (16) | Second | 4 out |
| Sunday, June 8 |
| » Defeated Yankees (32-23), 18-9 | Yankee Stadium (3-0) | 33-20 | Won 4 |
| » W: Ken Dixon (6-3) L: Ed Whitson (4-2) S: Tippy Martinez (1) | Second | 3 out |
| Monday, June 9 |
| » Lost to Brewers (29-26), 3-2 | County Stadium (0-1) | 33-21 | |
| » W: Dan Plesac (4-3) L: Storm Davis (5-5) | Second | 3 out |
| Tuesday, June 10 |
| » Lost to Brewers (30-26), 6-3 | County Stadium (0-2) | 33-22 | Lost 2 |
| » W: Bill Wegman (2-5) L: Scott McGregor (5-5) | Second | 4 out |
| Wednesday, June 11 |
| » Defeated Brewers (30-27), 4-3 | County Stadium (1-2) | 34-22 | |
| » W: Mike Boddicker (8-1) L: Danny Darwin (3-3) S: Don Aase (17) | Second | 4 out |
| Thursday, June 12 |
| » Lost to Yankees (35-24), 7-5 | Memorial Stadium (17-9) | 34-23 | |
| » W: Brian Fisher (2-2) L: Tippy Martinez (0-2) S: Dave Righetti (14) | Second | 4½ out |
| Friday, June 13 |
| » Lost to Yankees (36-24), 3-1 | Memorial Stadium (17-10) | 34-24 | Lost 2 |
| » W: Bob Tewksbury (5-2) L: Storm Davis (5-6) S: Dave Righetti (15) | Third | 5½ out |
| Saturday, June 14 |
| » Lost to Yankees (37-24), 4-2 | Memorial Stadium (17-11) | 34-25 | Lost 3 |
| » W: Dennis Rasmussen (6-2) L: Scott McGregor (5-6) S: Dave Righetti (16) | Third | 5½ out |
| Sunday, June 15 |
| » Defeated Yankees (37-25), 4-3 | Memorial Stadium (18-11) | 35-25 | |
| » W: Mike Boddicker (9-1) L: Brian Fisher (2-3) S: Don Aase (18) | Third | 4½ out |
| Monday, June 16 |
| » Lost to Tigers (28-32), 5-4 | Memorial Stadium (18-12) | 35-26 | |
| » W: Frank Tanana (7-4) L: Ken Dixon (6-4) S: John Pacella (1) | Third | 5½ out |
| Tuesday, June 17 |
| » Lost to Tigers (29-32), 6-3 | Memorial Stadium (18-13) | 35-27 | Lost 2 |
| » W: Randy O'Neal (1-3) L: Storm Davis (5-7) S: Guillermo Hernandez (11) | Third | 6½ out |
| Wednesday, June 18 |
| » Lost to Tigers (30-32), 6-1 | Memorial Stadium (18-14) | 35-28 | Lost 3 |
| » W: Eric King (3-0) L: Scott McGregor (5-7) | Third | 7½ out |
| Thursday, June 19 |
| » Lost to Tigers (31-32), 7-5 | Memorial Stadium (18-15) | 35-29 | Lost 4 |
| » W: Jack Morris (6-4) L: Don Aase (2-3) S: Guillermo Hernandez (12) | Third | 8 out |
| Friday, June 20 |
| » Defeated Red Sox (43-22), 14-3 | Fenway Park (1-0) | 36-29 | |
| » W: Mike Boddicker (10-1) L: Mike Brown (4-4) | Third | 7 out |
| Saturday, June 21 |
| » Lost to Red Sox (44-22), 7-2 | Fenway Park (1-1) | 36-30 | |
| » W: Roger Clemens (13-0) L: Ken Dixon (6-5) | Third | 8 out |
| Former Oriole Arnie Portocarrero dies in Kansas City, KS at the age of 55. |
| Sunday, June 22 |
| » Defeated Red Sox (44-23), 4-0 | Fenway Park (2-1) | 37-30 | |
| » W: Storm Davis (6-7) L: Jeff Sellers (0-3) S: Don Aase (19) | Third | 7 out |
| Tuesday, June 24 |
| » Defeated Tigers (32-35), 2-1 | Tiger Stadium (1-0) | 38-30 | Won 2 |
| » W: Don Aase (3-3) L: Bill Campbell (1-2) | Third | 5½ out |
| Wednesday, June 25 |
| » Lost to Tigers (33-35), 11-2 | Tiger Stadium (1-1) | 38-31 | |
| » W: Jack Morris (7-4) L: Mike Boddicker (10-2) | Third | 6½ out |
| Thursday, June 26 |
| » Lost to Tigers (34-35), 8-3 | Tiger Stadium (1-2) | 38-32 | Lost 2 |
| » W: Walt Terrell (7-5) L: Mike Flanagan (1-5) S: Guillermo Hernandez (14) | Third | 7 out |
| Friday, June 27 |
| » Lost to Red Sox (46-25), 5-3 | Memorial Stadium (18-16) | 38-33 | Lost 3 |
| » W: Roger Clemens (14-0) L: Ken Dixon (6-6) S: Bob Stanley (12) | Third | 8 out |
| Saturday, June 28 |
| » Lost to Red Sox (47-25), 7-3 | Memorial Stadium (18-17) | 38-34 | Lost 4 |
| » W: Oil Can Boyd (10-5) L: Storm Davis (6-8) S: Bob Stanley (13) | Third | 9 out |
| Sunday, June 29 |
| » Lost to Red Sox (48-25), 8-3 | Memorial Stadium (18-18) | 38-35 | Lost 5 |
| » W: Jeff Sellers (1-3) L: Mike Boddicker (10-3) | Fourth | 10 out |
| Monday, June 30 |
| » Defeated Brewers (37-37), 5-2 | Memorial Stadium (19-18) | 39-35 | |
| » W: Scott McGregor (6-7) L: Tim Leary (6-7) S: Don Aase (20) | Third | 10 out |
| Tuesday, July 1 |
| » Defeated Brewers (37-38), 7-3 | Memorial Stadium (20-18) | 40-35 | Won 2 |
| » W: Mike Flanagan (2-5) L: Bill Wegman (2-7) S: Rich Bordi (3) | Third | 10 out |
| Wednesday, July 2 |
| » Lost to Brewers (38-38), 1-0 | Memorial Stadium (20-19) | 40-36 | |
| » W: Juan Nieves (7-2) L: Ken Dixon (6-7) | Fourth | 10 out |
| Thursday, July 3 |
| » Lost to Twins (34-44), 11-7 | Hubert H. Humphrey Metrodome (1-2) | 40-37 | Lost 2 |
| » W: Bert Blyleven (7-7) L: Mike Boddicker (10-4) | Fifth | 10 out |
| Friday, July 4 |
| » Defeated Twins (34-45), 12-7 | Hubert H. Humphrey Metrodome (2-2) | 41-37 | |
| » W: Brad Havens (3-1) L: Frank Pastore (2-1) S: Don Aase (21) | Fourth | 10 out |
| Saturday, July 5 |
| » Lost to Twins (35-45), 7-6 | Hubert H. Humphrey Metrodome (2-3) | 41-38 | |
| » W: Frank Viola (9-6) L: Mike Flanagan (2-6) | Fifth | 10 out |
| Sunday, July 6 |
| » Defeated Twins (35-46), 1-0 | Hubert H. Humphrey Metrodome (3-3) | 42-38 | |
| » W: Ken Dixon (7-7) L: Neal Heaton (3-7) S: Don Aase (22) | Fourth | 10 out |
| Monday, July 7 |
| » Defeated Royals (37-45), 8-1 | Royals Stadium (2-2) | 43-38 | Won 2 |
| » W: Mike Boddicker (11-4) L: Charlie Leibrandt (8-6) | Fourth | 9 out |
| » Major-league debuts: Mike Kingery (Royals) |
| Tuesday, July 8 |
| » Defeated Royals (37-46), 8-4 | Royals Stadium (3-2) | 44-38 | Won 3 |
| » W: Odell Jones (1-0) L: Dan Quisenberry (0-3) | Fourth | 9 out |
| Wednesday, July 9 |
| » Lost to Royals (38-46), 3-0 | Royals Stadium (3-3) | 44-39 | |
| » W: Danny Jackson (5-6) L: Rich Bordi (3-1) S: Buddy Black (3) | Fourth | 10 out |
| Thursday, July 10 |
| » Defeated White Sox (38-45), 5-3 | Comiskey Park I (2-1) | 45-39 | |
| » W: Mike Flanagan (3-6) L: Joe Cowley (4-5) S: Brad Havens (1) | Fourth | 10 out |
| Friday, July 11 |
| » Defeated White Sox (38-46), 4-2 | Comiskey Park I (3-1) | 46-39 | Won 2 |
| » W: Ken Dixon (8-7) L: Floyd Bannister (5-5) S: Don Aase (23) | Fourth | 9 out |
| Saturday, July 12 |
| » Lost to White Sox (39-46), 6-3 | Comiskey Park I (3-2) | 46-40 | |
| » W: Gene Nelson (5-4) L: Mike Boddicker (11-5) S: Dave J. Schmidt (5) | Fourth | 10 out |
| Sunday, July 13 |
| » Lost to White Sox (40-46), 7-0 | Comiskey Park I (3-3) | 46-41 | Lost 2 |
| » W: Neil Allen (6-1) L: Scott McGregor (6-8) | Fourth | 10 out |
| Thursday, July 17 |
| » Defeated Twins (37-52), 6-2 | Memorial Stadium (21-19) | 47-41 | |
| » W: Ken Dixon (9-7) L: Frank Viola (9-8) S: Don Aase (24) | Fourth | 9 out |
| Friday, July 18 |
| » Lost to Twins (38-52), 7-3 | Memorial Stadium (21-20) | 47-42 | |
| » W: Bert Blyleven (9-8) L: Scott McGregor (6-9) S: Keith Atherton (7) | Fifth | 9 out |
| Saturday, July 19 |
| » Defeated Twins (38-53), 1-0 | Memorial Stadium (22-20) | 48-42 | |
| » W: Mike Flanagan (4-6) L: Neal Heaton (3-9) S: Don Aase (25) | Fourth | 9 out |
| Sunday, July 20 |
| » Defeated Twins (38-54), 8-3 | Memorial Stadium (23-20) | 49-42 | Won 2 |
| » W: Mike Boddicker (12-5) L: Mike Smithson (8-9) | Fourth | 8 out |
| Monday, July 21 |
| » Lost to Royals (43-50), 6-1 | Memorial Stadium (23-21) | 49-43 | |
| » W: Danny Jackson (6-6) L: Ken Dixon (9-8) S: Steve Farr (5) | Fifth | 8 out |
| Tuesday, July 22 |
| » Defeated Royals (43-51), 5-4 | Memorial Stadium (24-21) | 50-43 | |
| » W: Don Aase (4-3) L: Buddy Black (4-5) | Fourth | 7 out |
| Wednesday, July 23 |
| » Lost to Royals (44-51), 7-3 | Memorial Stadium (24-22) | 50-44 | |
| » W: Mark Gubicza (4-5) L: Scott McGregor (6-10) | Fifth | 7 out |
| Thursday, July 24 |
| » Defeated White Sox (42-52), 12-6 | Memorial Stadium (25-22) | 51-44 | |
| » W: Mike Flanagan (5-6) L: Joe Cowley (5-6) | Fourth | 6½ out |
| Friday, July 25 |
| » Defeated White Sox (42-53), 6-2 | Memorial Stadium (26-22) | 52-44 | Won 2 |
| » W: Mike Boddicker (13-5) L: Neil Allen (7-2) S: Don Aase (26) | Fourth | 6½ out |
| Saturday, July 26 |
| » Defeated White Sox (42-54), 2-1 | Memorial Stadium (27-22) | 53-44 | Won 3 |
| » W: Rich Bordi (4-1) L: Dave J. Schmidt (0-3) | Third | 5½ out |
| Sunday, July 27 |
| » Defeated White Sox (42-55), 11-3 | Memorial Stadium (28-22) | 54-44 | Won 4 |
| » W: Scott McGregor (7-10) L: Richard Dotson (7-11) | Third | 4½ out |
| Monday, July 28 |
| » Defeated Rangers (50-50), 4-3 | Arlington Stadium (2-2) | 55-44 | Won 5 |
| » W: Storm Davis (7-8) L: Charlie Hough (9-6) S: Don Aase (27) | Third | 4½ out |
| Tuesday, July 29 |
| » Lost to Rangers (51-50), 6-5 | Arlington Stadium (2-3) | 55-45 | |
| » W: Greg Harris (5-8) L: Odell Jones (1-1) | Third | 4½ out |
| Wednesday, July 30 |
| » Lost to Rangers (52-50), 5-3 | Arlington Stadium (2-4) | 55-46 | Lost 2 |
| » W: Jeff Russell (2-1) L: Nate Snell (2-1) | Third | 4½ out |
| Friday, August 1 |
| » Defeated Blue Jays (55-49), 7-3 | Exhibition Stadium (3-1) | 56-46 | |
| » W: Ken Dixon (10-8) L: Jimmy Key (9-7) | Second | 4½ out |
| Saturday, August 2 |
| » Defeated Blue Jays (55-50), 5-2 | Exhibition Stadium (4-1) | 57-46 | Won 2 |
| » W: Scott McGregor (8-10) L: Jim Clancy (12-6) S: Don Aase (28) | Second | 3½ out |
| Sunday, August 3 |
| » Lost to Blue Jays (56-50), 6-4 | Exhibition Stadium (4-2) | 57-47 | |
| » W: John Cerutti (6-3) L: Mike Flanagan (5-7) S: Tom Henke (16) | Second | 4½ out |
| Monday, August 4 |
| » Defeated Blue Jays (56-51), 12-2 | Exhibition Stadium (5-2) | 58-47 | |
| » W: Mike Boddicker (14-5) L: Joe Johnson (7-8) | Second | 3½ out |
| Tuesday, August 5 |
| » Defeated Rangers (55-52), 9-2 | Memorial Stadium (29-22) | 59-47 | Won 2 |
| » W: Storm Davis (8-8) L: Jose Guzman (8-11) | Second | 2½ out |
| Wednesday, August 6 |
| » Lost to Rangers (56-52), 13-11 | Memorial Stadium (29-23) | 59-48 | |
| » W: Mitch Williams (8-3) L: Rich Bordi (4-2) S: Dale Mohorcic (4) | Second | 3½ out |
| Thursday, August 7 |
| » Lost to Rangers (57-52), 9-8 | Memorial Stadium (29-24) | 59-49 | Lost 2 |
| » W: Jeff Russell (4-1) L: Brad Havens (3-2) S: Dale Mohorcic (5) | Second | 4 out |
| Friday, August 8 |
| » Lost to Indians (56-53), 3-0 | Memorial Stadium (29-25) | 59-50 | Lost 3 |
| » W: Tom Candiotti (11-8) L: Mike Boddicker (14-6) S: Ernie Camacho (15) | Third | 5 out |
| Saturday, August 9 |
| » Lost to Indians (57-53), 8-2 | Memorial Stadium (29-26) | 59-51 | Lost 4 |
| » W: Jose Roman (1-0) L: Storm Davis (8-9) | Third | 6 out |
| Sunday, August 10 |
| » Lost to Indians (58-53), 6-3 | Memorial Stadium (29-27) | 59-52 | Lost 5 |
| » W: Scott Bailes (9-7) L: Ken Dixon (10-9) S: Ernie Camacho (16) | Third | 7 out |
| Monday, August 11 |
| » Defeated Blue Jays (59-55), 3-1 | Memorial Stadium (30-27) | 60-52 | |
| » W: Mike Flanagan (6-7) L: Jimmy Key (10-8) S: Don Aase (29) | Third | 6 out |
| Tuesday, August 12 |
| » Lost to Blue Jays (60-55), 3-0 | Memorial Stadium (30-28) | 60-53 | |
| » W: Jim Clancy (13-6) L: Scott McGregor (8-11) | Fourth | 5½ out |
| Wednesday, August 13 |
| » Defeated Blue Jays (60-56), 7-6 | Memorial Stadium (31-28) | 61-53 | |
| » W: Don Aase (5-3) L: Luis Aquino (0-1) | Fourth | 5½ out |
| Thursday, August 14 |
| » Defeated Indians (58-57), 12-2 | Cleveland Stadium (2-2) | 62-53 | Won 2 |
| » W: Storm Davis (9-9) L: Jose Roman (1-1) | Third | 5½ out |
| Friday, August 15 |
| » Lost to Indians (59-57), 3-2 | Cleveland Stadium (2-3) | 62-54 | |
| » W: Frank Wills (1-1) L: Don Aase (5-4) S: Ernie Camacho (17) | Third | 6½ out |
| Saturday, August 16 |
| » Lost to Indians (60-57), 2-1 | Cleveland Stadium (2-4) | 62-55 | Lost 2 |
| » W: Phil Niekro (9-9) L: Mike Flanagan (6-8) S: Bryan Oelkers (1) | Fourth | 6½ out |
| Sunday, August 17 |
| » Lost to Indians (61-57), 11-6 | Cleveland Stadium (2-5) | 62-56 | Lost 3 |
| » W: Bryan Oelkers (2-2) L: Mike Boddicker (14-7) | Fourth | 7½ out |
| Tuesday, August 19 |
| » Lost to Athletics (53-68), 4-1 | Memorial Stadium (31-29) | 62-57 | Lost 4 |
| » W: Dave Stewart (6-1) L: Storm Davis (9-10) S: Jay Howell (11) | Fifth | 8 out |
| Friday, August 22 |
| » Defeated Angels (67-55), 8-7 | Memorial Stadium (32-29) | 63-57 | |
| » W: Rich Bordi (5-2) L: Donnie Moore (2-5) S: Don Aase (30) | Fifth | 9 out |
| Saturday, August 23 |
| » Defeated Angels (67-56), 4-2 | Memorial Stadium (33-29) | 64-57 | Won 2 |
| » W: Mike Flanagan (7-8) L: Ray Chadwick (0-3) S: Don Aase (31) | Fifth | 8 out |
| Sunday, August 24 |
| » Lost to Angels (68-56), 4-3 | Memorial Stadium (33-30) | 64-58 | |
| » W: Kirk McCaskill (14-7) L: Storm Davis (9-11) S: Donnie Moore (16) | Fifth | 8 out |
| Tuesday, August 26 |
| » Lost to Mariners (55-71), 5-2 | Kingdome (3-2) | 64-59 | Lost 2 |
| » W: Mike Moore (8-11) L: Ken Dixon (10-10) S: Matt Young (12) | Fifth | 8½ out |
| Wednesday, August 27 |
| » Lost to Mariners (56-71), 4-1 | Kingdome (3-3) | 64-60 | Lost 3 |
| » W: Mike Trujillo (1-0) L: Mike Boddicker (14-8) S: Mark Huismann (5) | Fifth | 8½ out |
| Thursday, August 28 |
| » Lost to Athletics (57-70), 5-4 | Oakland-Alameda County Stadium (2-1) | 64-61 | Lost 4 |
| » W: Dave Leiper (2-2) L: Don Aase (5-5) | Fifth | 9½ out |
| » Lost to Athletics (58-70), 8-7 | Oakland-Alameda County Stadium (2-2) | 64-62 | Lost 5 |
| » W: Bill Mooneyham (4-4) L: Don Aase (5-6) | Fifth | 9½ out |
| Friday, August 29 |
| » Lost to Athletics (59-70), 4-3 | Oakland-Alameda County Stadium (2-3) | 64-63 | Lost 6 |
| » W: Eric Plunk (4-7) L: Storm Davis (9-12) S: Jay Howell (13) | Seventh | 10 out |
| » Lost to Athletics (60-70), 4-0 | Oakland-Alameda County Stadium (2-4) | 64-64 | Lost 7 |
| » W: Dave Stewart (8-1) L: John Habyan (0-1) | Seventh | 10 out |
| Saturday, August 30 |
| » Defeated Athletics (60-71), 5-4 | Oakland-Alameda County Stadium (3-4) | 65-64 | |
| » W: Odell Jones (2-1) L: Jose Rijo (6-10) | Fifth | 10 out |
| Sunday, August 31 |
| » Lost to Athletics (61-71), 7-0 | Oakland-Alameda County Stadium (3-5) | 65-65 | |
| » W: Joaquin Andujar (8-6) L: Mike Boddicker (14-9) | Fifth | 11 out |
| Monday, September 1 |
| » Defeated Angels (74-57), 9-3 | Anaheim Stadium (2-2) | 66-65 | |
| » W: Scott McGregor (9-11) L: Mike Witt (16-8) | Fifth | 11 out |
| Tuesday, September 2 |
| » Lost to Angels (75-57), 10-1 | Anaheim Stadium (2-3) | 66-66 | |
| » W: Don Sutton (13-9) L: Mike Flanagan (7-9) | Fifth | 12 out |
| Wednesday, September 3 |
| » Lost to Angels (76-57), 5-2 | Anaheim Stadium (2-4) | 66-67 | Lost 2 |
| » W: Kirk McCaskill (15-7) L: Odell Jones (2-2) | Fifth | 13 out |
| Friday, September 5 |
| » Lost to Mariners (60-76), 8-2 | Memorial Stadium (33-31) | 66-68 | Lost 3 |
| » W: Mike Moore (10-11) L: Ken Dixon (10-11) | Sixth | 14 out |
| Saturday, September 6 |
| » Lost to Mariners (61-76), 6-2 | Memorial Stadium (33-32) | 66-69 | Lost 4 |
| » W: Mike Morgan (10-15) L: Mike Boddicker (14-10) | Sixth | 15 out |
| Sunday, September 7 |
| » Defeated Mariners (61-77), 8-0 | Memorial Stadium (34-32) | 67-69 | |
| » W: Scott McGregor (10-11) L: Mark Langston (11-11) | Sixth | 15 out |
| Monday, September 8 |
| » Lost to Red Sox (83-54), 9-3 | Memorial Stadium (34-33) | 67-70 | |
| » W: Calvin Schiraldi (3-1) L: Don Aase (5-7) | Sixth | 16 out |
| Tuesday, September 9 |
| » Lost to Red Sox (84-54), 7-5 | Memorial Stadium (34-34) | 67-71 | Lost 2 |
| » W: Al Nipper (9-9) L: Rich Bordi (5-3) S: Joe Sambito (12) | Sixth | 17 out |
| Wednesday, September 10 |
| » Lost to Red Sox (85-54), 9-4 | Memorial Stadium (34-35) | 67-72 | Lost 3 |
| » W: Roger Clemens (22-4) L: Ken Dixon (10-12) S: Calvin Schiraldi (8) | Sixth | 18 out |
| Thursday, September 11 |
| » Defeated Red Sox (85-55), 8-6 | Memorial Stadium (35-35) | 68-72 | |
| » W: Don Aase (6-7) L: Steve Crawford (0-1) | Sixth | 17 out |
| Friday, September 12 |
| » Lost to Tigers (74-68), 5-3 | Tiger Stadium (1-3) | 68-73 | |
| » W: Eric King (10-4) L: Scott McGregor (10-12) | Sixth | 18 out |
| Saturday, September 13 |
| » Lost to Tigers (75-68), 7-2 | Tiger Stadium (1-4) | 68-74 | Lost 2 |
| » W: Guillermo Hernandez (8-6) L: Mike Flanagan (7-10) | Sixth | 18 out |
| Sunday, September 14 |
| » Lost to Tigers (76-68), 7-0 | Tiger Stadium (1-5) | 68-75 | Lost 3 |
| » W: Frank Tanana (11-7) L: John Habyan (0-2) | Sixth | 18 out |
| » Major-league debuts: Ken Gerhart (Orioles) |
| Monday, September 15 |
| » Lost to Yankees (78-66), 5-3 | Yankee Stadium (3-1) | 68-76 | Lost 4 |
| » W: Tim Stoddard (5-4) L: Mike Boddicker (14-11) S: Dave Righetti (40) | Sixth | 18½ out |
| Tuesday, September 16 |
| » Lost to Yankees (79-66), 8-1 | Yankee Stadium (3-2) | 68-77 | Lost 5 |
| » W: Doug Drabek (6-7) L: Scott McGregor (10-13) S: Bob Shirley (3) | Fifth | 20 out |
| Wednesday, September 17 |
| » Defeated Yankees (79-67), 8-3 | Yankee Stadium (4-2) | 69-77 | |
| » W: Eric Bell (1-0) L: Bob Tewksbury (6-5) S: Don Aase (32) | Fifth | 20 out |
| Friday, September 19 |
| » Defeated Brewers (68-80), 3-1 | Memorial Stadium (36-35) | 70-77 | Won 2 |
| » W: Ken Dixon (11-12) L: Teddy Higuera (19-10) | Sixth | 19½ out |
| Saturday, September 20 |
| » Defeated Brewers (68-81), 4-3 | Memorial Stadium (37-35) | 71-77 | Won 3 |
| » W: John Habyan (1-2) L: Dan Plesac (9-7) S: Don Aase (33) | Sixth | 18½ out |
| Sunday, September 21 |
| » Lost to Brewers (69-81), 5-4 | Memorial Stadium (37-36) | 71-78 | |
| » W: Dan Plesac (10-7) L: Brad Havens (3-3) | Sixth | 19½ out |
| Monday, September 22 |
| » Lost to Yankees (81-69), 4-2 | Memorial Stadium (37-37) | 71-79 | Lost 2 |
| » W: Bob Tewksbury (7-5) L: Scott McGregor (10-14) S: Dave Righetti (41) | Fifth | 20 out |
| Tuesday, September 23 |
| » Lost to Yankees (82-69), 5-3 | Memorial Stadium (37-38) | 71-80 | Lost 3 |
| » W: Dave Righetti (8-7) L: Rich Bordi (5-4) | Fifth | 20 out |
| Wednesday, September 24 |
| » Lost to Yankees (83-69), 4-1 | Memorial Stadium (37-39) | 71-81 | Lost 4 |
| » W: Dennis Rasmussen (16-6) L: Mike Flanagan (7-11) S: Dave Righetti (42) | Fifth | 20½ out |
| Thursday, September 25 |
| » Lost to Brewers (71-81), 9-3 | County Stadium (1-3) | 71-82 | Lost 5 |
| » W: Teddy Higuera (20-10) L: Ken Dixon (11-13) | Seventh | 21 out |
| Friday, Septemb |